Map the tumor microenvironment Introducing GeoMx™ Digital Spatial Profiler – your GPS for immuno-oncology Quantify and locate up to 1000 RNA or Protein targets on a single slide with no tissue loss. Visit us at booth #888 Table of Contents General Information Welcome from the AMP Program Chair 2 Code of Conduct 7 Maps (Convention Center & HQ Hotels) 9 Highlights & General Information 13 AMP Central Schedule 23 Award for Excellence 2018 Recipient 25 Jeffrey A. Kant Leadership Award 2018 Recipient 26 Meritorious Service Award 2018 Recipient 27 2018 Travel Award Recipients 28 Board, Committee and Working Group Rosters 2018 29 Continuing Education Continuing Education Information 43 Continuing Education Tracker 50 Program Program-at-a-Glance 53 Program Listing 54 Thursday Program Thursday Session Descriptions 71 Friday Program Friday Session Descriptions 79 Saturday Program Saturday Session Descriptions 89 Speaker Information Speaker Bios 99 Poster Information Poster Information 121 Poster Listing 122 Author Index 149 Expo Information Explore the Expo Hall – Expo Information 171 Expo Floor Plan / Hours & Dates 172 Exhibitor Listing 174 Exhibitor Descriptions 176 6120 Executive Blvd, Suite 700 • Rockville, MD 20852 301-634-7987 • [email protected] Welcome to the 2018 Association for Molecular Pathology Annual Meeting & EXPO! It is my honor and great pleasure to welcome you to the 2018 AMP Annual Meeting and Expo. The theme of our meeting this year is “Precision Medicine Starts Here”. The Precision Medicine Initiative of the National Institutes of Health defines precision medicine as “an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person.” For an increasing number of diseases across a wide variety of medical specialties, the one-size-fits-all approach to patient diagnosis and treatment is becoming obsolete. As molecular pathology professionals, we lead the way in developing and applying new technologies to achieve the best patient care and outcome in this rapidly evolving field. We also play a vital role in educating our clinical colleagues, lay public, and elected officials of the value of the critical work that we do. Our Program Committee has worked hard to plan this year’s program. A major goal was to invite outstanding speakers whose work would be of broad interest across subdivisions, which we hope will encourage dialogue and foster discussion among attendees who work in different areas of molecular pathology. We believe that we have succeeded. One of those outstanding speakers, the recipient of the AMP Award for Excellence in Molecular Diagnostics, Dr. Jonathan Rothberg, will talk on “Reimagining Healthcare: Next Generation DNA Sequencing to Ultrasound-on-a-Chip.” Dr. Rothberg is recognized for his pioneering work in genomics, proteomics, and the development DNA sequencing technologies. He is also an entrepreneur who has founded several major biotechnology companies, whose technology we use daily in our molecular diagnostics laboratories. Planning and assembling a program for the annual meeting takes tremendous effort from the Planning Committee and the AMP staff. It is, without a doubt, a team effort. Chairing this committee is the easy part. The real work is done by the committee members and AMP staff. In addition to biweekly teleconferences to plan the program content, the committee members spent many additional hours identifying and inviting exciting speakers. I would like to recognize all of the subdivision committee members: Linda Jo Bone Jeng and Elaine Spector (Genetics), Eric Duncavage and Lynn Wang (Hematopathology), Belinda Yen- Lieberman, Jennifer Dien Bard, and David Hillyard (Infectious Diseases), Somak Roy and Matthew Lebo (Informatics), Lynette Marie Sholl and Christina Lockwood (Solid Tumors), Lynne Whetsell and Fernanda Sabato (Technical Topics), and Neal Lindeman, the incoming Program Chair. AMP committee members/volunteer groups are shaping and leading the field. Check out the many accomplishments and ongoing projects by reading the AMP Committee Reports on the AMP Website (https://www.amp.org/about/committees/) or in the Annual Meeting & Expo Mobile App. 2 #AMP2018 I would like to continue to extend my thanks to the AMP staff. They are models of organization, efficiency, and grace under pressure. Special thanks go to Sara Hamilton and Teniola Ayeni, who guided and supported the committee through the entire process of creating the program. Their expertise was invaluable. They coordinated and facilitated the teleconferences, organized the program, and kept us on task, which was not always easy. Many thanks also go to Lucia Barker and Kathleen Carmody, who coordinated the abstract submission and review processes. I also extend my sincere thanks to Tara Burke, Elisabeth Campbell, Eriko Clements, Rhonda Jenkins, Jon Korman, Laurie Menser, Andy Noble, Mrudula Pullambhatla, TaNika Switzer, Robyn Temple-Smolkin, Sarah Thibault-Sennett, Michele Zink, and Mary Steele Williams. I would also like to thank our corporate sponsors and exhibitors, who have helped support our 2018 meeting. I would encourage you to attend our Corporate Workshops on Wednesday, October 31, to learn about the newest technologies in our rapidly evolving field. Finally, many thanks to our attendees and the entire membership for making our meeting the premier gathering of molecular pathology professionals. This is THE place to network and get connected and involved. Please take advantage of everything the Annual Meeting & Expo has to offer. Have a great time in San Antonio, y’all! From the 2018 Program Committee, Lynne V. Abruzzo Lynne V. Abruzzo, MD, PhD 2018 Program Committee Chair 3 Precision Medicine Starts Here NOTES 4 #AMP2018 Bristol-Myers Squibb: at the forefront of Immuno-Oncology research Precision Medicine Starts with Pathology INFORMATION GENERAL At Bristol-Myers Squibb, we recognize pathologists play a crucial role in furthering advancements that may help predict which patients are likely to benefit from Immuno-Oncology therapies. To learn more, visit us at Booth 924 at the Association for Molecular Pathology Annual Meeting in San Antonio, November 1–3, 2018 The sponsor of this ad verifies that they had no input into decision making regarding selection of educational programs, content, or faculty for this 2018 Annual Meeting. For more information, please visit IOHCP.com and our YouTube channel at youtube.com/bmsIOresearch. © 2018 Bristol-Myers Squibb Company. All rights reserved. Printed in USA. IOUS1803476-03-01 10/18 IOUS1803476-03-01_AMP_Program_Ad_R03.indd 1 10/4/18 1:12 PM AMP_FP.qxp_Layout 1 9/28/18 11:36 AM Page 1 Simply Silaris. 31ST THRU DECEMBER GENERAL INFORMATION GENERAL INTRODUCING SILARIS™ INFLUENZA A&B TEST PCR Molecular Testing At The Point Of Care l Accurate l Affordable l Simple For more information visit us at silaris.com. For In Vitro Diagnostic Use Only © 2018 Sekisui Diagnostics, LLC. All rights reserved. Because every result matters™ and Silaris™ are trademarks of Sekisui Diagnostics, LLC. AMP_FP.qxp_Layout 1 9/28/18 11:36 AM Page 1 AMP 2018 Annual Meeting & Expo Code of Conduct Simply The Association for Molecular Pathology (AMP) is committed to providing a friendly, safe, and welcoming environment for all, regardless of gender, sexual INFORMATION GENERAL orientation, disability, race, ethnicity, religion, national origin, age, gender identity, or any other demographic group. We expect all attendees, media, speakers, AMP staff and volunteers, venue staff, contractors, guests, and Silaris. exhibitors to help us ensure a safe and positive annual meeting experience for everyone. While we cannot influence behavior outside of the official AMP annual meeting hours, we expect all participants at the AMP 2018 Annual Meeting & Expo to abide by this Code of Conduct in all venues, including ancillary events and all social gatherings. All participants are responsible for their own conduct. Anyone who is the recipient of 31ST unacceptable behavior should feel free to speak up without any fear of recrimination. THRU DECEMBER • AMP holds its collegial community in high value. Do your part to give everyone you encounter an enjoyable experience so they remember you and the meeting favorably. • Exercise consideration and respect in your speech and actions. • Abstain from all demeaning, discriminatory, or harassing behavior and speech. • Respect the fact that slides and posters may include unpublished work so do not photograph them without the presenter’s express permission. • Be mindful of your surroundings and of your fellow participants. Alert Security Personnel or call 911 if you notice a dangerous situation or someone in distress. • Notify AMP Staff of any violation of this Code of Conduct that you experience or observe. INTRODUCING SILARIS™ Unacceptable Behaviors INFLUENZA A&B TEST Unacceptable Behaviors Include: PCR Molecular • Intimidating, harassing, abusive, discriminatory, derogatory or demeaning Testing At The speech or actions • Harmful or prejudicial verbal or written comments, jokes, or visual images Point Of Care related to gender, sexual orientation, disability, race, ethnicity, religion, national l Accurate origin, age, gender identity, or any other demographic group l Affordable • Use of provocative and/or sexual images, including in presentation slides and exhibit booths l Simple • Deliberate intimidation, stalking, or following For more information • Harassing photography visit us at silaris.com. For In