Chromatin, Replication and Chromosomal Stability June 20-21, 2011 Stockholm, Sweden Conference Program June 20, 2011 08:30 – 09:20 Registration 09:20 – 09:30 Welcome and Introductions Camilla Sjögren 09:30 – 10:15 Keynote Speaker Helen Blau (Stanford University, US) Active DNA demethylation and reprogramming to pluripotency Session 1 Replication, Chromosome Structure and Cellular Memory Chair: Camilla Sjögren 10:15 – 10:45 Frank Uhlman (London Research Institute, UK) Chromosome condensation: compacting the budding yeast genome 10:45 – 11:00 Rosemary Wilson (University of York, UK) Chromatin loop remodeling during entry to and exit from quiescence 11:00 – 11:15 Kimberly Mikesh (Abcam) Abcam Break 11:45 – 12:15 Daniela Rhodes(University of Cambridge, UK) Chromatin structure and recognition 12:15 – 12:30 Takaharu Kanno (Karolinska Institute, Sweden) Purification and in vitro Characterizations of Smc5/6 Complex 12:30 – 13:00 Marcel Méchali (Institute of Human Genetics, CNRS, France) DNA replication: from origin recognition to genome stability Lunch and poster session Session 2 Chromatin Replication & Histone Dynamics Chair: Anja Groth 15:00 – 15:30 Alain Verreault (University of Montreal, Canada) Control of histone acetylation as a novel anti-fungal therapeutic strategy 15:30 – 15:45 Constance Alabert (BRIC, University of Copenhagen, Denmark) A new technology to dissect chromatin dynamics at replication forks 15:45 – 16:00 Sara Buonomo (EMBL Mouse Biology Unit, Italy) Rif functions during replication of pericentromeric heterochromatin 16:00 – 16:15 Anne Helmrich (IGBMC, France) Collisions between transcription and replication cause common fragile site instability Break Chromatin, Replication and Chromosomal Stability June 20-21, 2011 Stockholm, Sweden 16:45 – 17:15 Patrick Varga-Weisz (Babraham Institute, UK) Chromatin remodeling for epigenetic and genetic stability 17:15 – 17:30 Karl Ekwall (Karolinska Institute, Sweden) The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation 17:30 – 17:45 Dana Branzei (IFOM, Italy) Regulatory pathways controlling template switch intermediate formation and resolution throughout the cell cycle 17:45 – 18:00 Armelle Lengronne (Institute of Human Genetics, France) Regulation of replication forks progression by dNTP pools 18:00 – 20:00 Poster session and drinks reception Conference social Wenner-Gren Center (top floor) June 21, 2011 Session 3 Initiation, Timing and Epigenetic States Chair: Daniela Rhodes 09:00 – 09:30 David Gilbert (Florida State University, US) Developmental control of replication timing 09:30 – 09:45 Itamar Simon (Hebrew University – Hadassah Medical School, Israel) Genome-wide organization of DNA replication 09:45 – 10:00 Sabarinadh Chilaka (CNRS, Institut Jacques Monod, France) USF binding sites imposes early replication timing on a vertebrate replicator 10:00 – 10:30 Dean Jackson (University of Manchester, UK) Modeling human S phase to explore the efficiency of DNA synthesis Break Session 4 Replisome Structure, Fork Progression and Repair Chair: Catherine Green 11:00 – 11:30 Karim Labib (Cancer Research UK, UK) Chromosome stability and the eukaryotic replisome 11:30 – 11:45 Cosetta Bertoli (MRC Laboratory for Molecular Cell Biology, UK) The DNA replication checkpoint promotes E2F-dependent cell cycle transcription 11:45 – 12:00 Jakob Mejlvang (BRIC, University of Copenhagen, Denmark) Chromatin maturation controls replication fork speed 12:00 – 12:15 Akash Gunjan (Florida State University, US) Effect of histone gene dosage on the DNA damage sensitivity of budding yeast cells 12:15 – 12:30 Vincenzo Costanzo (London Research Institute, UK) The role of Rad51 and the Mre11/Rad50/Nbs1 complex in DNA replication Lunch Chromatin, Replication and Chromosomal Stability June 20-21, 2011 Stockholm, Sweden 14:00 – 14:30 Marco Foiani (IFOM, Italy) The replication checkpoint protects fork stability by releasing topological tension at nuclear pore gated genes 14:30 – 14:45 Lena Ström (Karolinska Institute, Sweden) Differential regulation of Damage induced cohesion in close vicinity of the actual break site and genome wide 14:45 – 15:00 Erik Johansson (Umeå University, Sweden) Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of Pol epsilon Break 15:30 – 16:00 Virginia Zakian (Princeton University, US) DNA replication through G-quadruplex motifs is promoted by the S. cerevisiae Pif1 DNA helicase 16:00 – 16:15 Duncan Smith (Sloan-Kettering Institute, US) Chromatin and the lagging strand 16:15 – 17:00 Keynote Speaker Michael O’Donnell (The Rockefeller University, US) The bacterial replisome has three polymerases and can morph into different structures while moving 17:00 Close Anja Groth .