Support Saturday, August 26th Lageplan 9.15 Invadolysin as a paradigm for modelling dynamics of the stromal Universitätsmedizin Mainz microenvironment in Drosophila Margarete Heck, Edinburgh 10.00 Intracellular Activation of Ovastacin Mediates Pre-fertilization Hardening of the Mouse Zona Pellucida Walter Stöcker, Mainz 10.30 The potential role of meprin beta in Alzheimer's Disease Claus Pietrzik, Mainz Registration 11.00 Coffee with the experts http://www.stauber-lab.de/ 11.30 Function of HtrA proteases in bacterial pathogenesis Silja Weßler, Salzburg Contact Roland Stauber 12.00 Posttranslational modifications Désirée Wünsch modulating Taspase1's activity University Medical Center Mainz Universitätsmedizin Mainz Langenbeckstr.1 Désirée Wünsch, Mainz 55131 Mainz 12.30 Time to say goodbye - Closing Email: [email protected] Bridge over troubled Remarks [email protected] Roland Stauber water - Proteases in Universitätsmedizin 13.00 End of the meeting der Johannes Gutenberg-Universität Mainz, Disease and Aging Langenbeckstr. 1, 55131 Mainz Conference Venue Lecture Hall, Building 102 August 24 - 26, 2017 Auf unserer Homepage www.unimedizin-mainz.de finden Mainz Sie Anfahrtsskizzen sowie mögliche Busverbindungen. Unser Wissen für Ihre Gesundheit Universitätsmedizin Mainz Thursday, August 24th Friday, August 25th 14.15 Dissecting interconnected 12.45 Get together - Lunch/Registration 9.00 Proteasome activation as a novel protease activation networks in Bridge over troubled Interdisciplinary tables to foster broad anti-ageing strategy complex biological matrices by scientific exchange Efstathios S. Gonos, Athen water - Proteases in targeted degradomics 9.30 Molecular control of biological Ulrich auf dem Keller, Zürich 13.45 Opening and welcome Disease and Aging aging: Macroautophagy as a Roland Stauber, Till Opatz, Désirée 14.45 TFIIA transcriptional activity is 'double-edged' sword in a complex Wünsch controlled by a 'cleave-and-run' celular quality control network Exportin-1/Taspase1-switch 14.00 Subunit-selective inhibitors and Heinz Osiewacz, Frankfurt Shirley Knauer, Essen Dear colleagues activity-based probes for human 10.00 Dissecting the proteasomes 15.15 Thrombin Inhibitors with Good C99/gamma-secretase interaction proteases play critical roles not only in numerous Hermen Overkleeft, Leiden Oral Pharmacokinetics: From in intramembrane proteolysis physiological but also pathological conditions throughout Mission Impossible to Mission 14.30 Inhibition of deubiquitinase (DUB) Dieter Langosch, München all biological kingdoms. Examples range from Accomplished activity is a promising strategy for development, neurological diseases, viral infections, and 10.30 Alzheimer's disease causing Kersten Gericke, Wuppertal cancer therapy cancer to aging. Therefore, proteases are not only of mutations prime gamma-Secretase Stig Linder, Stockholm academic but also clinical interest.Despite several - APP/An interactions for 15.45 Coffee with the experts break-troughs, many protease inhibitors failed in the 15.00 Inhibition of Cathepsin A: A novel dissociation, implications for drug clinics in the past, due to their inefficient binding, lack of strategy for the treatment of discovery 16.15 Natural products as starting target specificity, as well as incomplete understanding of cardiovascular diseases Lucia Chavez-Gutierrez, Leuven points for protease inhibitor the proteases' biochemistry and (patho)mechanisms. Sven Ruf, Frankfurt development and other chemical To meet these challenges and overcome current 11.00 Coffee with the experts tools limitations multidisciplinary research is required, 15.30 Coffee with the experts Markus Kaiser, Essen integrating latest developments in evolutionary research, 11.30 The Biology of the protease 16.45 Mechanism by which lipids shape medicinal and theoretical chemistry, structural and 16.00 Cysteine cathepsins as targets for ADAM17 reaction coordinates of rhomboid computational methods, nanotechnology, biochemistry, noninvasive whole body imaging Stefan Rose-John, Kiel proteases pharmacology, cell biology, and clinical studies. and targeted drug delivery 12.00 ADAM proteases in cancer - the Ana-Nicoleta Bondar, Berlin Bearing such considerations in mind, through this Boris Turk, Ljubljana symposium, we bring together leading researchers in both importance of intracellular protein experimental and computational communities to help 16.30 Cathepsin D in neuronal trafficking 17.30 A little less conversation - Science define pressing challenges and novel opportunities for homeostasis and cancer initiation - Marie Kveiborg, Kopenhagen and Food two sides of the same coin? Departure for Conference Dinner better understanding and exploiting the 'protease world'. 12.30 Role of intramembrane proteolysis Thomas Reinheckel, Freiburg Bootshaus Hence, we would appreciate to welcoming you on this in ER-associated degradation occasion at the University Medical Center Mainz! Marius Lemberg, Heidelberg 17.45 What goes around comes around - Science and Culture With best regards, 13.00 Another One Bites the Lunch: Guided city tour Mainz with the Christian Klein, Till Opatz, Roland Stauber, Walter Stöcker, Interdisciplinary tables to foster broad "Gutenberg Express" and Désirée Wünsch scientific exchange.