Centro Nacional de Biotecnología Campus de Cantoblanco RESEARCH Darwin 3, Madrid 28049, Spain Tel.: [+ 34] 91 585 4500 / Fax: [+ 34] 91 585 4506 DEVELOPMENT www.cnb.csic.es INNOVATION 2013/2014 REPORT INDEX Welcome to the CNB ................................................................................................................................................. 9 Carmen Castresana 1 / Plant Molecular Genetics 13 Genetic and molecular basis of naturally-occurring variation in plant development .............................................. 14 Carlos Alonso-Blanco Plant immunity strategies against microbial pathogen infection .............................................................................. 15 Carmen Castresana Genetic control of shoot branching patterns in plants ............................................................................................. 16 Pilar Cubas Plant-pathogen interaction in viral infections ........................................................................................................... 17 Juan Antonio García / Carmen Simón Genes involved in root architecture and in arsenic phytoremediation .................................................................... 18 Antonio Leyva Tejada Regulation of gene activity in plants: the phosphate starvation rescue system ...................................................... 19 Javier Paz-Ares Light signalling and day length control of potato tuber formation ........................................................................... 20 Salomé Prat Signalling networks in plant development and defence responses ........................................................................ 21 Jose J. Sánchez Serrano / Enrique Rojo Role of ubiquitin in the control of plant growth and stress tolerance ...................................................................... 22 Vicente Rubio The jasmonate signalling pathway in Arabidopsis ................................................................................................... 23 Roberto Solano 2 / Macromolecular Structures 25 Functional proteomics ............................................................................................................................................. 26 Juan Pablo Albar Three-dimensional electron and X-ray microscopies: image processing challenges ............................................. 27 José María Carazo Cell-cell and virus-cell interactions .......................................................................................................................... 28 José M. Casasnovas Structure of macromolecular assemblies ................................................................................................................ 29 José L. Carrascosa Viral molecular machines lab ................................................................................................................................... 30 José R. Castón Electron tomography and image processing of cell structures ............................................................................... 31 José Jesús Fernández Molecular biophysics of DNA repair nanomachines ................................................................................................. 32 Fernando Moreno-Herrero Conformational-functional behaviour of proteins .................................................................................................... 33 Víctor Muñoz Functional bioinformatics ......................................................................................................................................... 34 Alberto Pascual-Montano Cell structure lab...................................................................................................................................................... 35 Cristina Risco Ortiz Structural and physical determinants of adenovirus assembly ................................................................................ 36 Carmen San Martín Structure and function of molecular chaperones .................................................................................................... 37 José María Valpuesta Structural biology of viral fibres ............................................................................................................................... 38 Mark J. van Raaij 3 / Immunology and Oncology 39 Diferentiation and functional specialisation of dendritic cells during inflammatory, infectious and allergic processes ............................................................................................................................ 40 Carlos Ardavín Identification of activation and apoptosis regulators specific for controlling autoimmune T cell memory and inflammation .............................................................................................................................. 41 Dimitrios Balomenos Lymphocytes in physiological and pathological processes: autoimmune diseases, cancer immunotherapy, and nanobiomedicine ....................................................................................................... 42 Domingo F. Barber Cardiac stem cells ................................................................................................................................................... 43 Antonio Bernad Miana B cell dynamics ........................................................................................................................................................ 44 Yolanda R. Carrasco Molecular targets in health and disease: focus on PI3-kinase ................................................................................. 45 Ana C. Carrera Role of stress-activated protein kinase p38MAPK in human diseases .................................................................... 46 Ana Cuenda Cancer epigenetics ................................................................................................................................................. 47 Mario Fernández Fraga Anti-tumour activity of chemokine receptor-specific antibodies.............................................................................. 48 Leonor Kremer Signalling networks in inflammation and cancer ..................................................................................................... 49 Santos Mañes Stem cells and immunity ......................................................................................................................................... 50 Carlos Martínez-A Chemokine receptors: new targets for therapeutic intervention ............................................................................. 51 Mario Mellado Role of diacylglycerol kinases in the control of immune response and cancer progression................................... 52 Isabel Mérida Function of the c-Myc proto-oncogene in vivo ........................................................................................................ 53 Ignacio Moreno de Alborán APRIL signalling pathway regulation and function ................................................................................................... 54 Lourdes Planelles Receptor ligand interactions in immune responses to cancer and viruses ............................................................. 55 Hugh Reyburn T cell signalling in autoimmune diseases and cancer ............................................................................................. 56 Jesús María Salvador Tumour immune activation and evasion .................................................................................................................. 57 Mar Valés Gómez 4 / Molecular and Cellular Biology 59 Molecular basis of cytoskeletal reorganisation: the role of actin polymerisation in neuritogenesis, inflammation and metastasis ...................................................................................................... 60 Inés M. Antón Coronavirus: replication, virus-host interactions, and protection ............................................................................. 61 Luis Enjuanes Poxvirus and vaccines ............................................................................................................................................. 62 Mariano Esteban Infection by hepatitis C viruses ................................................................................................................................ 63 Pablo Gastaminza Landart Biological noise ....................................................................................................................................................... 64 Francisco J. Iborra Animal models by genetic manipulation .................................................................................................................. 65 Lluís Montoliu Functional analysis of the transcriptional repressor DREAM ................................................................................... 66 José Ramón Naranjo Cerebral cortical development ................................................................................................................................ 67 Marta Nieto López Mechanisms of interaction between the influenza virus and the infected cell ........................................................ 68 Amelia Nieto Transcription and replication of influenza virus RNA ............................................................................................... 69 Juan Ortín Molecular characterisation and epidemiology of torovirus .....................................................................................