5/25/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Visited Concepts Suggest changes to this concept Anti-alphaVbeta3 Monoclonal Antibody EMD 525797 (CUI C2830088) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C2830088 NCI Thesaurus Code: C82422 (see NCI Thesaurus info) Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Immunologic Factor NCIt Definition: A humanized monoclonal antibody directed against the human alpha v integrin subunit with potential antiangiogenic and antineoplastic activities. Anti-human integrin alpha v subunit monoclonal antibody EMD 525797, a chimeric antibody which includes the antigen binding sites of the anti-integrin mouse antibody 17E6, binds to and inhibits the activity of alphaVbeta3 integrin (vitronectin receptor); this may result in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in alphavbeta3-expressing tumor cells. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is expressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration. PDQ Definition: A humanized monoclonal antibody directed against the human alpha v integrin subunit with potential antiangiogenic and antineoplastic activities. Anti-human integrin alpha v subunit monoclonal antibody EMD 525797, a chimeric antibody which includes the antigen binding sites of the anti-integrin mouse antibody 17E6, binds to and inhibits the activity of alphavbeta3 integrin (vitronectin receptor); this may result in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in alphavbeta3-expressing tumor cells. Alphavbeta3 integrin, a cell adhesion and signaling receptor, is expressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration. Check for active clinical trials using this agent. (NCI Thesaurus) Synonyms & Abbreviations: (see Synonym Details) Anti-alphaVbeta3 Monoclonal Antibody EMD 525797 anti-human CD51 monoclonal antibody EMD 525797 Anti-Human Integrin Alpha v Subunit Monoclonal Antibody EMD 52579 anti-human integrin alpha v subunit monoclonal antibody EMD 525797 EMD 525797 External Source Codes: NCI Thesaurus Code C82422 (see NCI Thesaurus info) PDQ Closed Trial Search ID 638087 PDQ Open Trial Search ID 638087 (check for NCI PDQ open clinical trial info) Other Properties: Name Value Source Contributing_Source CTRP NCI DATE_FIRST_PUBLISHED 2009-03-13 PDQ DATE_LAST_MODIFIED 2009-08-14 PDQ NCI_THESAURUS_CODE C82422 PDQ ORIG_STY Drug/agent PDQ TERMUI T000870694 MSH TH NLM (2014) MSH Additional Concept Data: (none) URL to Bookmark: https://ncim.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C2830088 Synonym Details: Term Source Type Code Anti-alphaVbeta3 Monoclonal Antibody EMD 525797 NCI PT C82422 anti-human CD51 monoclonal antibody EMD 525797 PDQ SY CDR0000638087 anti-human integrin alpha v subunit monoclonal antibody EMD 525797 PDQ PT CDR0000638087 https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?dictionary=NCI%20Metathesaurus&code=C2830088&type=all 1/61 5/25/2018 NCI Metathesaurus Anti-Human Integrin Alpha v Subunit Monoclonal Antibody EMD 52579 PDQ LV CDR0000638087 EMD 525797 MSH PCE C000592911 EMD 525797 NCI CCN C82422 EMD 525797 PDQ CON CDR0000638087 Relationships with other NCI Metathesaurus Concepts: Parents | Children | Broader | Narrower | Siblings | Other Parent Concepts: Relationship Rel. Attribute Name Rel. Source Parent isa Antineoplastic Antibody NCI Parent isa Monoclonal Antibodies NCI Parent Pharmaceutical Preparations PDQ Child Concepts: (none) Broader Concepts: Relationship Rel. Attribute Name Rel. Source Broader DI17E6 MSH Narrower Concepts: (none) Sibling Concepts: Relationship Rel. Attribute Name Rel. Source Sibling Abortifacient Agents CSP Sibling antagonists & inhibitors CSP Sibling Anti-Allergic Agents CSP Sibling Anti-Infective Agents CSP Sibling Anti-Inflammatory Agents CSP Sibling antiarthritic agent CSP Sibling antidiuretic CSP Sibling Antidote CSP Sibling Antimetabolites CSP Sibling Antineoplastic Agents CSP Sibling Antirheumatic Agents CSP Sibling Antispasmodic Agent CSP Sibling Biological Factors CSP Sibling Carcinogen CSP Sibling Cardiovascular Agents CSP Sibling Chelating Agents CSP Sibling Chemical Surfactants CSP Sibling Choleretic agent CSP Sibling Cryoprotective Agent CSP Sibling dental agent CSP Sibling Diuretic CSP Sibling expectorant/mucolytic CSP Sibling eye agent CSP Sibling Fertility Agents CSP Sibling Gastrointestinal Agents CSP Sibling Gout Suppressants CSP Sibling Hematologic Agents CSP Sibling hyperglycemic agent CSP Sibling Hypoglycemic Agents CSP Sibling Immunomodulators CSP Sibling Mitogens CSP Sibling Multidrug Resistance Modulator CSP Sibling Muscle relaxants CSP Sibling Mutagen CSP Sibling Neuromuscular Blocking Agents CSP Sibling neuropharmacologic agent CSP Sibling nonenzyme proteolytic agent CSP Sibling Oxytocics CSP Sibling Pesticide CSP Sibling Photosensitizing Agent CSP Sibling Progestins CSP Sibling psychopharmacologic agent CSP Sibling Pyrogen CSP Sibling Radioprotective Agent CSP Sibling Radiosensitizing Agent CSP Sibling stimulant/agonist CSP Sibling Teratogen CSP Sibling Tocolytic Agents CSP https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?dictionary=NCI%20Metathesaurus&code=C2830088&type=all 2/61 5/25/2018 NCI Metathesaurus Sibling Vitamins CSP Sibling weight control agent CSP Sibling XomaZyme CSP Sibling Antibodies, Monoclonal, Murine-Derived MSH Sibling controlled substance MSH Sibling Cosmeceuticals MSH Sibling Counterfeit Drugs MSH Sibling Designer Drugs MSH Sibling Dosage Forms MSH Sibling Drugs, Chinese Herbal MSH Sibling Drugs, Essential MSH Sibling Drugs, Non-Prescription MSH Sibling Drug Combinations MSH Sibling Generic Drugs MSH Sibling Humanized Monoclonal Antibody MSH Sibling infliximab MSH Sibling Investigational New Drugs MSH Sibling Materia Medica MSH Sibling Medical Marijuana MSH Sibling Nostrums MSH Sibling Pharmaceutical Preparations, Dental MSH Sibling Pharmaceutic Aids MSH Sibling Placebos MSH Sibling Plant Extracts MSH Sibling Prescription Drugs MSH Sibling Prodrugs MSH Sibling Single-Chain Variable Fragment MSH Sibling Solutions MSH Sibling Street Drugs MSH Sibling Veterinary Drugs MSH Sibling Xenobiotics MSH Sibling 11D10 AluGel Anti-Idiotype Monoclonal Antibody NCI Sibling 3H1 Aluminum Hydroxide-Precipitated Anti-Idiotype Monoclonal Antibody NCI Sibling A33 monoclonal antibody NCI Sibling abagovomab NCI Sibling Abciximab NCI Sibling adalimumab NCI Sibling Adecatumumab NCI Sibling Agonistic Anti-CD40 Monoclonal Antibody ADC-1013 NCI Sibling alemtuzumab NCI Sibling Alpha-Beta T-Cell Receptor Antibody NCI Sibling Amatuximab NCI Sibling Anrukinzumab NCI Sibling Anti-A33 Monoclonal Antibody KRN330 NCI Sibling Anti-A5B1 Integrin Monoclonal Antibody PF-04605412 NCI Sibling Anti-AGS-16 Monoclonal Antibody AGS-16M18 NCI Sibling Anti-AGS-8 Monoclonal Antibody AGS-8M4 NCI Sibling Anti-ALK-1 Monoclonal Antibody PF-03446962 NCI Sibling Anti-alpha5beta1 Integrin Antibody MINT1526A NCI Sibling Anti-amyloid Monoclonal Antibody NEOD001 NCI Sibling Anti-ANG2 Monoclonal Antibody MEDI-3617 NCI Sibling Anti-angiopoietin Monoclonal Antibody AMG 780 NCI Sibling Anti-AXL Monoclonal Antibody-MMAE Conjugate NCI Sibling Anti-B7-H3 Antibody DS-5573a NCI Sibling Anti-c-fms Monoclonal Antibody AMG 820 NCI Sibling Anti-c-KIT Monoclonal Antibody KTN0158 NCI Sibling Anti-c-Met Monoclonal Antibody ABT-700 NCI Sibling Anti-c-Met Monoclonal Antibody ARGX-111 NCI Sibling Anti-c-MET Monoclonal Antibody LY2875358 NCI Sibling Anti-C-met Monoclonal Antibody SAIT301 NCI Sibling Anti-CA19-9 Monoclonal Antibody 5B1 NCI Sibling Anti-CD122 Humanized Monoclonal Antibody Mik-Beta-1 NCI Sibling Anti-CD123/CD3 Monoclonal Antibody MGD006 NCI Sibling Anti-CD123 Monoclonal Antibody CSL360 NCI Sibling Anti-CD123 Monoclonal Antibody KHK2823 NCI Sibling Anti-CD157 Monoclonal Antibody MEN1112 NCI Sibling Anti-CD19/CD3 Tetravalent Antibody AFM11 NCI Sibling Anti-CD19 Antibody-drug Conjugate SGN-CD19B NCI Sibling Anti-CD19 Monoclonal Antibody NCI Sibling Anti-CD19 Monoclonal Antibody XmAb5574 NCI https://ncim.nci.nih.gov/ncimbrowser/pages/concept_details.jsf?dictionary=NCI%20Metathesaurus&code=C2830088&type=all 3/61 5/25/2018 NCI Metathesaurus Sibling Anti-CD20/CD3 Monoclonal Antibody REGN1979 NCI Sibling Anti-CD20/CD3 Monoclonal Antibody XmAb13676 NCI Sibling Anti-CD20 Monoclonal Antibody-Interferon-alpha Fusion Protein IGN002 NCI Sibling Anti-CD20 Monoclonal Antibody PRO131921 NCI Sibling Anti-CD20 Monoclonal Antibody SCT400 NCI Sibling Anti-CD20 Monoclonal Antibody TL011 NCI Sibling Anti-CD20 x Anti-CD3 Bispecific Monoclonal Antibody BTCT4465A NCI Sibling Anti-CD22 Monoclonal Antibody-MMAE Conjugate DCDT2980S NCI Sibling Anti-CD25-PBD Antibody-drug Conjugate ADCT-301 NCI Sibling Anti-CD25 Monoclonal Antibody NCI Sibling Anti-CD2 Monoclonal Antibody NCI Sibling Anti-CD3/Anti-CD20 Trifunctional Bispecific Monoclonal Antibody FBTA05 NCI Sibling Anti-CD30/CD16A Monoclonal Antibody AFM13 NCI Sibling Anti-CD30 Monoclonal Antibody MDX-1401 NCI Sibling Anti-CD30 Monoclonal