577 lor; Aknecolor; Canestene; Corisa!; Fungotox; Gromazol; Gyno­ Econazole Nitrate (BANM. USAN, r/NNM) Canestene; Imazol; Undex au clotrimazole; Thai.: Caginal; CAS - 130- 16-5. Canasone; Canazol; Candazole; Candex; Candid; Candinox; BPF36H!G6S. (..Q4707 .Ec_qnaiol, hltf to pitrat� d'; UNII - a tc61'l.-?Z6f€;, . Canesten; Cenecon; Chingazol; Clomaz; Clotri; Clotricin; Clo­ Ecor'!a.iqll _Nrtras; Econazo.• lrl \leri: Ekonats olilitttaa�tt:. E�<:ma· trimed; Comatt; Comazol; Cotren; CSTt; Defungo; Dermaten; Profile zo lnitrat; Ek<:�mzbl-rrltrat;: Ekonazofl1.r,i o.- Mtfrato de Dermizole; Fadaet; Fango Cream; Fungi; Fungicon; Fungiderm; . · nltraa tas;rp Gynebo; Gynestin 200; Gyno-Clotrin; Gynosten; Hofra B; Cloxiquine has been included in preparations used topically eco�a40!; R7 148c27; 3k9Ha3PJJ fi•r a+. Hofra; Kanezint; Kenet; Klamacin; Lamazone; Lyma; Manoma­ for the treatment of fungal and bacterial skin infections. It is (±)-I-{2A:Dkhloro.-f:lc\4'chSQ- !3050;lorob€ rqifoxy)phefjeth;.rl)ln11d· a component of halquinol. p. 309.1. ato!e> nitrate: . · · · zole; Mycoda; Mycoderm-C; Mycoril; Mycotopic; Mycozole; .\ . Myda; Nestic; P-Gyzole; RanoTroct; Taraten; Vagizole; Vama­ CiaH15CisN,0,HN0-;""444· .7 zole; Vanesten; Zema; Turk.: Canesten; Clozol; Fungostent; . - J4 169-Q2-6 (ec onozofe, . Gyno-Canesten; UK: Canesten Combi; Canesten; Fungederm; CAS ProprietaryPreparations (details are given in Volume B) . Ukr.: Candibene (Kmwr6eHe); Candid (KaHAH!1): Imazol Aeconazql�TC-.- 001AC nitrate).03: . (llMa3on); USA: Fungi Cure Intensive; Gyne�Lotrimin; Lotrimin Decoderm trivalentt; . Multi-ingredient Preparations. Austria: 000iA.GOIACb3,' F0-5: AF; Lotrimin; Mycelex-7; Mycelex; Venez.: Canesten; Clortilen; Indon.: Decoderm 3. Clotrizol; Fugolin; Ginolotricomb; Gyno Canesten; Imazol; Ipa­ ATC Vet ....,. QGIJ IA}:(Js. UN/I H43/JWVIIJ iVE. lat; Micozol; Palik. Pharmacopoeias. In Chin., Eur. (see p. and US. Multi-ingredient Preparations. Arg. : Becortin; Calmurid; Cortis­ Croconazole Hydrochloride fr!NNMJ Ph. Eur. 8: (Econazole Nitrate). A whitevii), or almost white pec; Dicasone Complex; Empecid Cort; Gentacort Plus; Hongal; Claconazole Hydi chlorlde; Crcieonozol. Chlorhydrate e; crystalline powder. Very slightly soluble in water; slightly Lotricomb; Micomazol B; Quadriderm; Quiacort G Plus; Vagi­ () d Crocoriazol; hidrocloruro de; CroconilZoli Hydtochlciriduin; soluble in alcohol; sparingly soluble in dichloromethane; san Compuesto; Vitacortil; Austral.: Canesoral Duo; Femazole soluble in methyl alcohol. Protect from light. Duo; Hydrozole; VagiClear Duo; Austria: Imazol Duo; Myko Hidrocloruro . de . croconazol; . (crownazole); Cordest; Belg.: Lotriderm; Braz.: Baycuten; Canad.: Canesoral f\pol<oHa30!1aTvtA P0X!10PV!A: 710674-S USP 36: (Econazole Nitrate). A white or practically white, . Combi-Pak; Lotriderm; Chile: B-Laboterol; Baycuten; Clotri­ 1-(1-(o-[(m.(hlorobenzyl)oxy] phenylMnyl)imictazo!e hydro-· crystalline powder, with not more than a slight odour. Very rnin-B; Creminem-B; Cutanil; Dermicin B; Donomix; Locrim; chloride. slightly soluble in water and in ether; slightly soluble in Lotriderm; Novadrel; Novamela; Telugren Plus; Tribesona; alcohol; sparingly soluble in chloroform; soluble in methyl .. China: Clotrasone Shan Qing ( Shuang Zuo Tai C,8H,1C!N,O,HCI"'347(crocona 4 ;;.o!e). alcohol. Protect from light. (���); 77175-51-Q Cz.: Imacort;(:f;l'li\;f' Imazol,.;); Plus; Denm.:W).K); Clotrason; Ger.: CAS � . Antifungolt; Baycuten HC; Fungidexan; Imazol camp; Imazol :c-:IOWF113l3HZ . UNII. Uses and Administration Plus; Imazol; Lotricomb; Myko Cordes Plus; Gr.: Lotriderm; Pharmacopoeias. In Jp n. Hong Kong: Candacort; Canesten HC; Clobert-Gt; Clobeta-G; Econazole is an imidazole antifungal used topically in the Clotrim·Bt: Clotrinolon; Cobetsolt; Dermacloft; Derzid-C; treatment of superficial candidiasis (see p. 564.1) and in Lozopint: Synco·CFNt; Triderm; Tridewelt; Uni·Quadermt; Profile dermatophytosis and pityriasis versicolor (see Skin Infec­ India: Adcort; Advin-NC; Aliderma; Alvi; Arima; Atasol; Bacla­ Croconazole is an imidazole antifungal used topically in the tions, p. 568.1). sia-CG; Baclasia-CN; BC-Zole; BC-Zole; Beclasone-C; Beclocid­ treatment of superficial cutaneous candidiasis, dermato­ Econazole nitrate is applied topically up to 3 times daily G; Beclocid; Beclocin-0; Beclolab-CG; Beclolab-NC; Beclotis-C; phytosis, and pityriasis versicolor. It is applied as a as a 1% cream, lotion, powder, or solution in the treatment Beclotis-CG; Becmet-CG; Becmet-CG; Bectop; Benda; Bestec; cream or gel containing the hydrochloride. I% of fungal skin infections. Treatment is continued for 2 to 4 Bestonim C; Bestopic-N; Bugderm; Caltec; Candasia-B; Candi­ For a discussion of the caution needed when using azole weeks. It is also used in the treatment of vaginal candidiasis biotic; Candid B; Candid Ear Drops; Candid-CL; Candid-TV; antifungals during pregnancy, see under Pregnancy in Candiderma Candidenna; Candigen-BG; Candikit-N; Candi­ as pessaries of 150 mg once daily at bedtime for 3 +; Precautions of Fluconazole, p. 579.3. vate; Canesten-S; Canison-B; Canison-BN; Canison-C; Cane­ consecutive nights; a single dose of 150 mg in a long-acting derma; Cazol-B; CBL; Ceflox-CF; Cezel-PT; Ciprolar·FC; CLCD; formulation has also been used. Intravaginal use of 5 g of a P epa a ons cream once daily at night has been given for 2 weeks. A Clenorush; Clevyx; Clima-V; Clingen Plus; Clingen; Cloat-V; ............r r ....ti . Cloben-G; Cloben; Clobiotic; Clocain; Clocip B; Clocip Clo­ .. l%1% cream may be used concurrently for the treatment of NB; ProprietaryPreparations (details are given in Volume B) daz·V6; Clofung GM; Clofung-G; Clofung·N; Clofung; Clomax vulval infections or for the treatment of balanitis in a male BN; Clomax-B; Clomax-BG; Clomycint; Clorid-B; Clovar-V; Single-ingredient Preparations.Jpn: Pilzcint. partner. Clozed; CNB; Convoy; Corge-C; Cuticare; Cutigard; Dandruff In the treatment of fungal infections of the nails, a Plus; Decand B; Decand BG; Dennaspan; Derrninol; Diprogen; cream or lotion is applied once daily and covered with I%an Drep; Drocort; Eligao; Epicort-GC; Everbate; Evergum; Excan; Eberconazole Nitrate (r!NNM) occlusive dressing. Flucocip; Fourderm AF; Fubac; Fungi-BC; Fungidrops; GCB; tberconazole, Nitrate Eberconazolt Nltras; Nitrilto de Econazole nitrate has also been used as eye or ear drops. Gentacort-MF; Gentalene Plus; Gentalene-C; Ginal-V; Ginal-V; Econazole sulfosalicylate has also been used. Ginlac-V; Hill-Y; Hydrozole; !FE; Ifyclo·G; Imidil B; Imidil Plus; eberwnazol; '76epK(1Ha3oRader HMrpar. Imidil-CV; Infabact; Itchasia; ltchicos; Itchicure; Itchipol; (:f)·· l-(2,4-0ichloro-10, l 10inydro-Sfl,diberizo[a,d]cyd0hep- · Lamonte-BG; LBC; Leobet-NC; Leozole-B; Lotriderm; Lotril-B; ren,5'yl)imictaz.ole Adverse Effects and Precautions Lotril-BG; Lotril-LB; Mycoderm; Myconip-C; Myconorm; . C r1fn ate. Local reactions including burning and irritation may occur Mycotic; Naderm RF; NC Derm; Neobate; Neocip PC; Nifugal-B; {eberconozo!&;, ,.- H�H 5.=5<:11 .2 when econazole nitrate is applied topically. Contact Nivate-NC; Nuforce-CD; Nuforce-GM; Olotic; Onderm; Otek­ P1No;N0 dermatitis has been reported rarely. AC Plus; Otichek; Otiden; Otiderm; Otiflox; Otocin-0; Otocin; ATCCAS -: DOIAC1128326-87.2·9 V<'t - Otocos; Otosym; Sigmaderm; Sofradex-F; Surfaz-SN; Surfaz; �K Q[{O IAC1.7. Intravaginal preparations of econazole may damage latex Translipo-Triple; Indon.: Baycuten-N; Heltiskint; Lotriderm; contraceptives and additional contraceptive measures are Irl.: Canesten HC; Lotriderm; Israel: Agisten Agisten with Profile therefore necessary during local application. Aloe Vera; Clotrisone; Hydroagisten; Polycutan; I;Tevacutan; Tri­ For a discussion of the caution needed when using azole derm; Ital.: Desamix Effe; Medon; Malaysia: Baycuten Nt; Eberconazole nitrate is an imidazole antifungal used antifungals during pregnancy, see under Pregnancy in Betamethasone Clo; Candacort; Candid B; Triderm-C; Mex. : topically as a 1% cream in the treatment of superfidal Precautions of Fluconazole, p. 579.3. Barmicil Compuesto; Baycuten N; Baycuten; Beclogen; Beclo­ fungal infections of the skin. trin; Betrigen; Clotricina; Gelmicin; Miclobet; Prubagen; Quad­ For a discussion of the caution needed when using azole Porphyria. The Drug Database for Acute Porphyria, com­ riderm NF; Qudermin; Triderrn; Xyloderm; Neth.: Imazol Duo; antifungals during pregnancy, see under Pregnancy in piled by the Norwegian Porphyria Centre (NAPOS) and NZ: Canesten Duo; Philipp.: Baycuten; Candacort; Candibec; Precautions of Fluconazole, p. 579.3. the Porphyria Centre Sweden, classifies econazole (for Clotrasone; Combidenn; Triderm; Pol.: Imazol Plus; Lotriderm; gynaecological use) as probably porphyrinogenic; it should Triderm; Port.: Baycuten; Beta·Micoter; Flotiran; Quadriderrne; References. I. del Palado A, et al. A double-blind randomized comparative trial: be prescribed only for compelling reasons and precautions Rus.: Akriderm GK (AKpH.!lepM rK); Candibiotic (KaH�H6HornK); eberconazole I% cream versus dotrimazole l% cream twice daily in should be considered in all patients. Dermatological pre· Candid B (KaHAHA E); Candiderm (KaHWIA<JlM); Canison Plus Candida and dermatophyte skin infections. Mycoses 2001; 44: 173-80. parations are classified as probably not porphyrinogenic; (Kmrn3oH Ilmoc); Metrogyl Plus (MerpoiWI Ilmoc); Triderm 2. Repiso Montero T, et a!. Eberconazole 1% cream is an effective and safe they may be used as drugs of first