Gineco.eu [12] 112-114 [2016] DOI: 10.18643/gieu.2016.112 @ 2016 Romanian Society of Ultrasonography in Obstetrics and Gynecology Invasive molar pregnancy in a woman aged 54 years. A case report Antoniu Abstract Cringu Ionescu1, We reported a 54-year-old patient with a complete hydatidiform mole invasive in myometrium. This diagnostic was Mariana suggested by irregular vaginal haemorrhage, amenorrhea and reduced nausea. The paraclinical investigations which Bragaru2, suggest the diagnosis were: pelvic ultrasound and level of serum beta-human chorionic gonadotropin (β-hCG). Endovaginal Mihai ultrasound revealed enlarged uterus volume, with diameter of 12/15/8 cm, and the presence of multiple nodular formations Dimitriu1, located intramural and subserosal and a mass with Doppler rich blood supply through myometrium and endometrium. The level of β-hCG was 28099.00 mIU/L. The treatment was abdominal hysterectomy and bilateral salpingo-oophorectomy. Iulia Maria Anatomopathological report revealed a complete invasive mole and endometrial polyp. After the surgical intervention the Tarcomnicu2, patient was treated with methotrexate as prophylactic chemotherapy recommended by oncologists because of the invasive Camelia character of mole and age of patient. The complete invasive mole is a benign tumor that is characterized by abnormal Teodora proliferation of trophoblast and is locally invasive. Developing pregnancy rate in perimenopause period is very rare and most 2 of the pregnancies that occur at this age are abnormal, spontaneous abortion occurring most often. We choose to report Vladescu , this case to emphasize that this condition can occur in a relatively advanced age, especially during perimenopause period. Mihai Banacu1 Keywords: molar pregnancy, perimenopause, beta-human chorionic gonadotropin 1. UMF ”Carol Davila”, Department of Obstetrics and Gynecology, ”Sf. Pantelimon” Clinical Emergency Hospital, Bucharest, Romania 2. Department of Obstetrics Introduction necology “St. Pantelimon” Clinical Emergency Hospital, and Gynecology, Gestational trophoblastic disease is characterized by Bucharest from Romania with heavy vaginal bleeding “St. Pantelimon” Clinical Emergency Hospital, abnormal proliferation of trophoblastic tissue. The short for the last two days. Her first pregnancy had been in Bucharest, Romania 3. Department classification is partial hydatidiform mole, complete mole, 1989, and the second had been a twin pregnancy in of Pathology, invasive mole, placental site trophoblastic tumor, placental 1991, full-term spontaneous births. Her second delivery “St. Pantelimon” Clinical Emergency Hospital, site nodule and plaque, epithelioid trophoblastic tumor, was at the age of 30. From the personal physiological Bucharest, Romania exaggerated placental site reaction and choriocarcino- history, the patient had two miscarriages, never used Correspondence: ma(1,2). A molar pregnancy occurs at fertilization, when any combined oral contraceptives or other hormonal Dr. Antoniu Crîngu Ionescu e-mail: antoniuginec@ instead of a normal pregnancy, evolve a mass of cysts. The therapy, with no history of comorbidities and collateral yahoo.com complete molar pregnancy is a non-cancerous tumor that disease. At admission she presented irregular menstrual develops in the uterus. In its composition is no placental bleeding in the last year. The patient has normal weight or embryo normal tissue. The invasive mole is a form of and she has a medium socioeconomic status. She arri- complete molar pregnancy evolution(3). Although this ved in our hospital complaining for persistent vaginal disease is characterized by an aggressive development it is hemorrhage for the last two months, associated with actually locally invasive usually without distance dissemi- reduced nausea and four months of amenorrhea before. nation, but sometimes can also appear distant metastases. Physical examination was normal. After gynecological It is defined as a category of mole that penetrates and exam we found an enlarged uterus volume at a 12-week may even perforate the uterine wall. Rarely can spread to pregnancy, consistency firmly, and irregular in shape. other organs such as vagina, vulva and lung. Macroscopic The speculum and vaginal examination showed a cli- is characterized by trophoblastic invasion of myometrium nical normal cervix with abundance uterine bleeding. with villous structures. Microscopic is characterized by Blood analysis as hemoleucograma, coagulograma, liver citotrofoblast hyperplasia, syncytial elements and villo- enzymes, glucose, urea, and creatinine were normal. us structures persistence(3,4). The invasive mole can be Endovaginal ultrasound examination showed enlarged distinguished from chorio-carcinoma by the presence of uterus volume, with dimensions 12/15/8 cm, with villi. An invasive mole develops in approximately 10-20% the presence of multiple nodular formations located of patients after molar evacuation and infrequently after intramural and subserosal. Endometrial thickness was other gestations. 1.8 cm, diffuse inhomogeneous with a vascular mass, Received: May 21, 2016 with a rich blood supply in the myometrium and endo- Revised: Case Report metrium. The left ovary present a transonic formation June 14, 2016 Accepted: A 54-year-old Caucasian woman, from urban society, 4,63/3.68 cm. Right ovary was normal, without liquid July 12, 2016 was hospitalized in Department of Obstetrics and Gy- in cul-de-sac Douglas (Figure 1). 112 Vol. 12 • No. 45 (3/2016) Ionescu et al. Invasive molar pregnancy in a woman aged 54 years... gineco eu Figure 1. Transvaginal ultrasound: myomas of uterus with a thick endo- metrium and cyst on right ovary In our diagnostic algorithm the possibility of a fi- Intraoperative examination showed volume enlarged bromatous uterus was considered. Other etiologies uterus, irregular outline, with normal serosa, left ovary of endometrial bleeding like endometrial benign or with a cystic formation, right ovary as normal, the rest malign pathologies or ovarian pathologies were also of intraabdominal organs were macroscopic normal. possible. A normal or pathological pregnancy at this Histopathology revealed a complete mole with myo- age was not estimate. metrium invasion, an invasive hydatiform mole, en- In 31 October, 2014 the pacient was hospitalized, was dometrial polyp, intramural leiomyoma, endocervical performed a dilatation and curettage of endometrial glandular hyperplasia, left ovarian dermoid cyst. The cavity. The tissue that was extracted was macrosco- invasive mole was distinguished from choriocarcinoma pic irrelevant. The hystopathological report revealed by the presence of chorionic villi. In choriocarcinomas chorionic villis and stromal degeneration (e.g. molar there are extensive areas of necrosis and haemorrhage villi), compatible with a complete hydatidiform mole and distinct absence of chorionic villi (Figure 3). (Figure 2). There were not pre-, intra- and post-operative compli- On 25 November 2014, our pacient was admitted cations. After the surgical intervention the patient was to hospital for serum measurement of beta-chorionic treated with methotrexate as prophylactic chemothe- gonadotropin (β-hCG) which was 28099.00 mIU/L rapy for six weeks. The treatment was recommended and for preoperative preparation. Blood analyzes, by oncologist because of invasive mole with potential group and Rh factor were completed with abdominal to metastasis and because of the age of patient. The ultrasound examination, chest radiograph, computed imunohystochemistry exam was not further completed tomography thorax and abdomen was normal. in our hospital. Considering the patient’s age and after informed After eight weeks since the surgical operation, serum consent a laparotomy and hysterectomy with bilateral β-hCG level returned back to zero. In this condition the salpingo-oophorectomy were decided. prognosis of our patient was favorable. The patient Figure 2. Pathological report: complete mole- syncytiotrofoblast area Figure 3. Pathological report: syncitiotrofoblast proliferation, proliferated and citotrofoblast, HE staining x 20 HE staining x 20 Vol. 12 • No. 45 (3/2016) 113 Ionescu et al. Invasive molar pregnancy in a woman aged 54 years... remained under oncology surveillance, with regular in patients at extreme age(9,10). It was assumed that dosage of the serum β-hCG level. Rarely this disease our patient was in perimenopause period (e.g. with may spread to other parts of the body, such as the no other hormonal investigations were carried out for vagina, vulva and lung. this diagnosis) with irregular menstrual bleeding. First diagnosis considered was fibroid uterus. Discussion Any other causes of endometrial bleeding also were Gestational trophoblastic disease represents a class considered: endometrium, myometrium, ovary malig- of lesions characterized by an abnormal proliferation nancies or benign lesions. of trophoblast. It is known that the appearance of A trophoblastic disease was not estimate, also be- pregnancy in perimenopause period is extremely low(1). cause β-hCG measurement was not performed initi- There are a number of factors that make both concep- ally. Most women will only need a minor surgery for a tion and a healthy pregnancy more difficult for older trophoblastic disease (biopsy curettage), to remove the women. Perimenopause ovulation becomes irregular, molar tissue. But a small percentage of this will need making conception more difficult. chemotherapy(11). In case of our patient it was decided Men