US 20180271910A1 ( 19) United States (12 ) Patent Application Publication ( 10) Pub . No. : US 2018 /0271910 A1 Mata - Fink et al. (43 ) Pub . Date : Sep . 27 , 2018 ( 54 ) METHODS AND COMPOSITIONS FOR 2014 , provisional application No. 61/ 991, 319 , filed IMMUNOMODULATION on May 9 , 2014 , provisional application No . 61 / 973 , 764 , filed on Apr. 1 , 2014 , provisional application No. (71 ) Applicant : RUBIUS THERAPEUTICS , INC . , 61/ 973 ,763 , filed on Apr . 1 , 2014 . Cambridge , MA (US ) ( 30 ) Foreign Application Priority Data (72 ) Inventors : Jordi Mata - Fink , Somerville , MA (US ) ; John Round , Cambridge , MA Nov . 12 , 2014 (US ) .. .. .. PCT/ US2014 / 065304 (US ) ; Noubar B . Afeyan , Lexington , MA (US ) ; Avak Kahvejian , Arlington , Publication Classification MA (US ) (51 ) Int. CI. A61K 35 / 28 ( 2015 .01 ) ( 21 ) Appl. No. : 15 /911 , 924 C12N 5 / 078 ( 2010 . 01) A61K 48 / 00 ( 2006 .01 ) (22 ) Filed : Mar. 5 , 2018 C12N 5 /07 ( 2010 . 01 ) A61K 35 / 12 (2015 . 01) Related U . S . Application Data (52 ) U . S . CI. (63 ) Continuation of application No . 15 / 301, 046 , filed on CPC . .. .. .. A61K 35 / 28 ( 2013 .01 ) ; C12N 5 / 0644 Sep . 30 , 2016 , filed as application No . PCT/ US2015 / (2013 .01 ) ; C12N 5 / 0641 ( 2013 . 01 ) ; A61K 020614 on Mar . 13 , 2015 . 2035 / 124 (2013 . 01 ) ; C12N 5 / 06 ( 2013 . 01 ) ; (60 ) Provisional application No . 62/ 059 , 100 , filed on Oct . A61K 2035 / 122 (2013 .01 ) ; A61K 48 / 00 2 , 2014 , provisional application No . 62 /025 , 367 , filed ( 2013. 01 ) on Jul. 16 , 2014 , provisional application No. 62 / 006 , 828 , filed on Jun . 2 , 2014 , provisional application No . (57 ) ABSTRACT 62/ 006 ,825 , filed on Jun . 2 , 2014 , provisional appli Provided are cells containing exogenous antigen and uses cation No . 62 /006 ,829 , filed on Jun . 2 , 2014 , provi thereof . sional application No . 62 /006 , 832 , filed on Jun . 2 , Specification includes a Sequence Listing . 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