19th ISCB International Conference (ISCBC-2013) RECENT ADVANCES AND CURRENT TRENDS IN CHEMICAL AND BIOLOGICAL SCIENCES 2nd -5th March, 2013 Jointly organized by Mohanlal Sukhadia University , Udaipur,313001 ,Rajasthan, India & Indian Society of Chemists & Biologists, Lucknow, India SCIENTIFIC PROGRAM Saturday, March 2, 2013 9.30 AM -11.30 Registration PM 11.30 PM-1.00 Inaugural Session PM Welcome Address: Prof. I. V. Trivedi ,Vice-Chancellor, Mohan Lal Sukhadia University Introduction to Dr. P.M.S. Chauhan, Gen.Secretary, ISCB. ISCB: Presidential Prof. Anamik Shah, President ISCB Address: Address by Chief Guest Prof.Jyoti Chattopadhyaya, Professor & Chair, Program of Chemical Biology, Dept. of Cell & Molecular Biology, Uppsala University, Sweden Address by Guests of Prof.Victor Kartsev, Russia Honour Prof Michael D. Threadgill, UK Prof.Cynthia J. Burrows, USA Prof.Athina Geronikaki , Greece ISCB AWARD Lectures ISCB LIFE TIME ACHIEVEMENT AWARD ISCB AWARD FOR EXCELLENCE ISCB YOUNG SCIENTIST AWARD Vote of Thanks: Prof. A. K. Goswami, Convener & Chair 1.00-2.00PM Lunch i Session – I Chairpersons: Dr.S.B.Katti and Dr.Rajesh Luthra PL-1 Jyoti Chattopadhyaya, Professor & Chair,Program of Chemical Biology, 2.00 PM-2.30 PM Dept. of Cell & Molecular Biology, Uppsala University,Sweden New Free-radical Ring closure Metathesis to give Modified DNA or RNA to Potential Therapeutics or Diagnostics PL-2 Victor Kartsev , InterBioScreen, PO Box 218, Moscow, 119019 Russia 2.30 PM-3.00 PM Novel Rearrangements in Targeted Synthesis of Natural Compound Analogs IL-1 Cynthia J. Burrows, University of Utah, , USA 3.00-3.20 SINGLE-MOLECULE STUDIES OF OXIDATIVE DAMAGE IN TELOMERIC G QUADRUPLEXES IL-2 Brenton DeBoef, Department of Chemistry ,University of Rhode Island 3.20-3.40 ,Kingston,USA Synthesis of C-C and C-N bonds via oxidative C-H functionalization IL-3 P.M.S.Chauhan,Medicinal and Process Chemistry Division, Central Drug 3.40-4.00 Research Institute Lucknow, Rachna Sadana, ,Assistant Professor of Biology and Biochemistry, IL-4 Houston, USA 4.00-4.20 Screening Novel Synthetic Compounds for their Cytotoxicity and Inhibition of Tubulin Polymerization Tea 4.20-4.40PM IL-5 Fernando Albericio, Professor ,Organic Chemistry Dept. – UB, Spain, Therapeutic Nanoconjugates 4.40-5.00PM IL-6 Krishna Nand Singh, Professor of Organic Chemistry, Department of Chemistry 5.00-5.20PM Development of Some Green Protocols for Organic Synthesis IL-7 Pratibha Mehta Luthra, Dr. B.R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi 5.20-5.40PM Design and Development of thioxothiazoles as A2A receptor antagonists in the therapy of Parkinson's Disease 5.40 PM – 7.30 PM Poster Session -1(Poster Numbers 1-100) 7.30 PM – 8.30 PM Cultural Programme 8.30 PM Dinner Sunday, March, 3-03-2013 ii SESSION – II: Chairpersons: Prof Michael D. Threadgill & Dr.P.M.S.Chauhan PL-3, René Grée, Directeur de Recherche CNRS,Université de Rennes 1Institut des 9.00 AM-9.30 AM Sciences Chimiques de Rennes, CNRS UMR 6226,Avenue du Général Leclerc,35042 RENNES Cedex, France Design, Synthesis and Biological Evaluation for Analogues of Bioactive Biarylic Polyphenols PL-4 Tushar Kanti Chakraborty, Director, CSIR-CDRI, Lucknow , India 9.30 AM-10.00 AM OSDDChem: A CSIR Initiative to Connect Chemists & Biologists IL-8 Steven E. Rokita, Department of Chemistry,Johns Hopkins University,3400 N. 10.00 AM -10.20 AM Charles St., Baltimore, MD 21218, USA. DYNAMIC AND TARGETED ALKYLATION OF DNA IL -9 Mahesh K. Lakshman, Professor,Department of Chemistry,The City College 10.20 AM-10.40 AM and The City University of New York 160 Convent Avenue, New York, NY 10031. N-Directed C–H Bond Activation in Purines and Purine Nucleosides IL -10 Arun K. Shaw, , CSIR-Central Drug Research Institute, Lucknow 10.40 AM-11.00 Stereoselective Synthesis of Aminocytitols by Using Carbohydrate Based Building Blocks: Formal Synthesis of (+)-Conduramine E and (-)- Conduramine E IL -11 Ashok K. Prasad ,University of Delhi, Delhi From Glucose to Modified Nucleosides, pH Sensitive Sugar-based 11.00-11.20 Polymers and Crown Ethers of Importance Tea: 11.20 AM-11.40 PM Session-III Chairpersons: Prof. A. K. Goswami and Prof. Ashok K. Prasad IL-12 Donal O'Shea,School of Chemistry & Chemical Biology,University College 11.40 AM-12.0 PM Dublin,Dublin, BF2-Azadipyrromethene Based in vivo Near Infrared Fluorescence Imaging Platforms IL-13 Athina Geronikaki , Department of Pharmaceutical Chemistry, 12.00PM-12.20 PM Aristotle University, Greece Design and synthesis of novel (4/6-substituted benzo[d] thiazol-2- yl)thiazolidinone-4 ones with antimicrobial activity IL-14 Anshu Dandia , Centre of Advanced Studies, Department of 12.20 PM -12.40 PM Chemistry,University of Rajasthan, Jaipur- India Green nanotechnology: Towards Synthesis of Pharmaceutically and Biologically pertinent Moieties IL-15 Diwan S Rawat, Department of Chemistry, University of Delhi, Delhi Antimalarial Drug Development: From Simple in vitro Screening to 12.40 PM-1.00PM Lead Identification IL-16 R.I. Kureshy,Discipline of Inorganic Materials and Catalysis, Central Salt and Marine Chemicals Research Institute (CSMCRI), Council of Scientific & 1.00-1.20PM Industrial Research (CSIR), G. B. Marg, Bhavnagar- 364 002, Chiral Catalysis an Important Tool for the Synthesis of Pharmaceutically Active Molecules iii Lunch 1.20 PM - 2.20 PM Session-IV Chairpersons: Prof.Steven E. Rokita and Prof. Rajesh Dhakarey IL-17 Maria Laura Bolognesi, Department of Pharmaceutical Sciences,Via 2.20 PM-2.40 PM BelmeloroBologna, Italy Designing multitarget drugs for neurodegenerative diseases IL-18 Tsann-Long Su,Research Fellow,Institute of Biomedical Sciences, Academia 2.40 PM-3.00 PM Sinica, Taipei ,Taiwan. Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition IL-19 Ram Vishwakarma, Indian Institute of Integrative Medicine, Jammu, 3.00 PM-3.20 PM Chemical biology of GPI molecules IL-20 Barbara Zajc, The City College and The City University of New York 3.20 PM -3.40 PM Doubly Functionalizable Reagents in Protio and Fluoro Julia-Kocienski Olefination IL-21 S.B.Katti,Head, Medicinal and Process Chemistry Division, Central Drug 3.40 PM -4.00 PM Research Institute Lucknow, India 4-Aminoquinoline derivatives as antimalarial agents IL-22 Vishnu K. Tandon,Department of Chemistry, University of Lucknow, 4.00-4.20 Regio-, chemo- and Enantioselective reactions in H2O towards synthesis of biologically active compounds Tea 4.20 PM -4.40 PM Session-V Chairpersons: Prof. Anamik Shah and Prof Mahesh K. Lakshman IL-23 S K Puri, Division of Parasitology, CSIR-Central Drug Research Institute, 4.40-5.00 Lucknow, 226001 India, Targeting the dormant ‘Hypnozoites’ for malaria elimination IL-24 Suniti Dharwadkar,Head, Biochemistry Department, S. B.College of Science, Aurangabad-431001, (M.S.) India 5.00-5.20 Role of Biotransformation in Pharmacological Actions of Drugs and in Drug Development: Significance of Cytochrome P-450 Enzymes. O-1 Indresh Kumar, Department of Chemistry,Birla Institute of Technology and 5.20 PM-5.30 PM Sciences-Pilani, Pilani An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: Asymmetric synthesis of 2,3-substituted pyrrolidines O-2 5.30 PM-5.5.40 PM Sandip T. Gadge, Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai ,India. Oxidative aminocarbonylation of terminal alkynes for the synthesis of alk- iv 2-ynamides by using palladium-on-carbon as efficient, heterogeneous, phosphine-free, and reusable catalyst O-3 Aniruddha B. Patiland, , Department of ChemistryICT Technology, Mumbai 5.40PM-5.50 PM Selective and efficient synthesis of decahedral palladiumnanoparticles and its catalytic application for Suzuki coupling reaction Umakant B. Patil, Department of Chemistry, ICT, Matunga (E), Mumbai - 400 O-4 019, India 5.50 PM-6.00 PM A novel method for the synthesis of 5-subtituted 1H-tetrazole from Oxime and Sodium Azide O-5 A. K. Gupta and R.S. Dubey, Department of Biochemistry, Faculty of Science, 6.00 P M-6.10 PM Banaras Hindu University, Varanasi, Synthesis And Evaluation Of Antioxidant Activities Of Some New 3- Substituted-2-Oxindole Derivatives O-6 Vivek K. Vyas and Manjunath Ghate, Department of Pharmaceutical 6.10 PM-6.20 PM Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India, Pharmacophore modeling, 3D QSAR, virtual screening, docking and in silico pharmacokinetic and toxicities prediction studies of protein kinase B (AKT β) inhibitors O-7 Hardik G. Bhatt and Paresh K. Patel, Department of Pharmaceutical 6.20 PM-6.30 PM Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India, Discovery of hiv-i integrase inhibitors: pharmacophore mapping, database searching, molecular docking, synthesis and in silico pharmacokinetic & toxicities prediction. 6.30 PM-7.00PM Industry Academia Interaction 7.00 PM – 8.00 PM Poster Session -II (Poster Numbers 100-200) 8.00 PM – 8.30 PM Cultural Programme 8.30 PM Dinner v Monday, March-04-2013 SESSION –VI Chairpersons: Prof. Jyoti Chattopadhyaya and Prof. Athina Geronikaki PL-5 Mukund S. Chorghade, CSO, AGN Biofuels, 14 Carlson Circle, Natick, MA 9.00 AM – 9.30 AM 01760 Pre-treatment of Bagasse: A Chemists’ Approach to Lignin Depolymerization PL-6 Prof. Anil K. Singh, Vice Chancellor,University of Allahabad,Allahabad & 9.30 AM – 9.50 AM Professor, Department of Chemistry, IIT Bombay A Chemical Approach to PhotobiologyBioorganic and Excited State Studies of Retinal Related Photoreceptors IL-25 Laurent El Kaim, Enseignant-Chercheur,UMR 7652,DCSO (Ecole Polytechnique) 9.50 AM - 10.10 AM Paris ,France New cyclizations of Ugi and Ugi-Smiles adducts. IL-26 Han-Chung Wu 10.10 AM – 10.30 Institute of Cellular and Organismic Biology, Academia Sinica, Taipei 115, Taiwan PM Ligand-Mediated Drug Delivery Systems for Cancer Targeted Imaging and Therapy IL-27 Rajiv Sharma (Senior Vice-President Medicinal chemistry, PLSL, Mumbai 10.30 PM – 10.50 P7170, an Orally Efficacious, Anti-cancer Clinical Candidate Targeting PM PI3K/mTOR & ALK-1 Kinases Tea : 10.50 AM - 11.10 AM Session VII Chairpersons: Prof.