Shiyue LI 李時悅, MD, Professor of Medicine

Director, Department of Respiratory Medicine The 1st Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Deputy Director, Guangzhou Institute of Respiratory Health State Key Laboratory for Respiratory Disease

Address #151 West Yan Jiang Road, Guangzhou 510120, China

Short CV 1980.9 - 1985.7 M.D ,Guangzhou Medical College, China 1985.7 -1988.9 Resident, 2nd Affiliated Hospital of Guangzhou Medical College 1988.9 - 1991.7 Master Degree, Respiratory medicine Guangzhou Medical College 1991.7 - 1997.11 Resident and Consultant, The 1st Affiliated Hospital of Guangzhou Medical College 1997.2 - 1999.5 Visitng Scholar, National Center for Toxitological Research, USA Since 1999.5 Associated Professor, Professor, The 1st Affiliated Hospital of Guangzhou Medical College, China

Honours and Awards 2018 “Leading Doctor for Respiratory Disease” awarded by Health Committee of Guangdong, China 2017 “Excellent Respiratory Physician in China” awarded by Chinese Association for Medical Doctors 2012 Second Class Award，Award for Scientific and Technological Advancement, Guangzhou, China. “Clinical application and Innovation for interventional Pulmonology” 2011 Outstanding Award for Endoscopy, Branch of Endoscopy, Association for Chinese Doctors. 2004 Second Class Award，Award for Scientific and Technological Advancement, Guangdong Province, China. “Epidemiology, Prevention, Control, Diagnosis and Management for HIV/ AIDS in Guangdong Province”

Memberships / Committee Assignments: 2008 – 2017 Former Regent, the World Association of Bronchology and Interventional Pulmonology (WABIP) Since 2014 Regent, Asian-pacific Association for Bronchology and Interventional Pulmonology (APAB) Since 2012 Vice Head, Section of Interventional Pulmonology, Chinese Thoracic Society Since 2012 Chairman, Division of Respiratory Disease, Guangzhou Medical Association, China Since 2010 Member, American College of Chest Physicians Since 2016 Chairman, Division of Respiratory Physician, Guangdong Association for Doctors. Since 2016 《Respiration》， Editorial Board Member Since 2015 《Chinese Journal of Tuberculosis and Respiratory Diseases》，Editorial Board Member

Publications: （first author or equal, correspondent author indicated as boldface） 1. Li S, Wang G, Wang C, Gao X, Jin F, Yang H, Han B, Zhou R, Chen C, Chen L, Bai C, Shen H, Herth FJF, Zhong N. The REACH Trial: A Randomized Controlled Trial Assessing the Safety and Effectiveness of the Spiration® Valve System in the Treatment of Severe Emphysema. Respiration. 2018，14:1-12. doi: 10.1159/000494327 2. Su ZQ#, Guan WJ#, Li SY#, Ding M, Chen Y, Jiang M, Chen XB, Zhong CH, Tang CL, Zhong NS*. Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD[J]. International journal of chronic obstructive pulmonary disease, 2018, 13: 3031—3044. 3. Zhou ZQ, Zhong CH, Su ZQ, Li XY, Chen Y, Chen XB, Tang CL, Zhou LQ, Li SY. Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis. Respiration. 2018 Sep 18:1-10. doi: 10.1159/000492031

Division of Cardiothoracic Surgery, Department of Surgery, The Chinese University of Hong Kong 4/F, Lui Che Woo Clinical Sciences Building, Prince of Wales Hospital, Shatin, NT, Hong Kong Tel: (852) 3505 2629 / 3505 3586Fax: (852) 2637 7974 Email: [email protected]Website: www.surgery.cuhk.edu.hk/ATCCS2019

4. Su Z, Cheng Y, Wu Z, Zhang P, Chen W, Zhou Z, Zhong M, Luo W, Guo W, Li S: Incidence and Predictors of Tracheobronchial Tuberculosis in Pulmonary Tuberculosis: A Multicentre, Large-Scale and Prospective Study in Southern China. Respiration 2018:1-7. doi: 10.1159/000492335. 5. Zhou, Chengzhi and Qin, Yinyin and Zhang, Dehua and Xie, Zhanhong and Lin, Xinqing and Zhang, Jiexia and Li, Shiyue* and Chen, Rongchang* and Zhong, Nanshan, Clinical efficacies of gemcitabine combined with docetaxel single or plus bevacizumab as second-line therapy for malignant pleural mesothelioma[J]. Translational Cancer Research, 2018, 7(1):48-54. （IF2017:1.200） 6. Zhong C H, Tong D, Zhou Z Q, Su ZQ, Luo YL, Xing J, Bai YL, Guo SJ, Li SY. Performance evaluation of detecting circulating tumor cells and tumor cells in bronchoalveolar lavage fluid in diagnosis of peripheral lung cancer.[J]. Journal of Thoracic Disease, 2018, 10(S7):S830-S837. （IF2017:1.804） 7. Guo WL, Zhou ZQ, Chen LU, Su ZQ, Zhong CH, Chen Y, Li SY. Serum KL-6 in pulmonary alveolar proteinosis: China compared historically with Germany and Japan. J Thorac Dis 2017;9(2):287-295 8. Ding M, Chen Y, Guan WJ, Zhong CH, Jiang M, Luo WZ, Chen XB, Tang CL, Tang Y, Jian QM, Wang W, Li SY, Zhong NS. Measuring Airway Remodeling in Patients With Different COPD Staging Using Endobronchial Optical Coherence Tomography. Chest. 2016. 150(6): 1281-1290. 9. Shi-yue Li, Qiang Li, Wei-jie,Jiang huang, Nan-shan Zhong et al. Effects of para-toluenesulfonamide intratumoral injection on non-small cell lung carcinoma with severe central airway obstruction: A multi-center, non-randomized, single-arm, open-label trial. Lung Cancer. 2016,98:43-50 10. Wang J, Zeng Y, Luo W, Xie X, Li S. The Role of Cryptococcus in the Immune System of Pulmonary Cryptococcosis Patients. PLoS One. 2015 ,10(12):e0144427 11. Chen Y, Ding M, Guan WJ, Wang W, Luo WZ, Zhong CH, Jiang M, Jiang JH, Gu YY, Li SY, Zhong NS. Validation of human small airway measurements using endobronchial optical coherence tomography. Respir Med. 2015;109(11):1446-53. doi: 10.1016. 12. Guo WL, Chen Y, Zhong NS, Zhong CG, Li SY. Alveolar proteinosis in extremis:a critical case treated with whole lung lavage without extracorporeal membrane oxygenation. Int J Clin Med 2015 15;8(10):19556-60. 13. Zhou C, Qin Y, Xie Z, Zhang J, Yang M, Li S, Chen R. NPTX1 is a novel epigenetic regulation gene and associated with prognosis in lung cancer. Biochem Biophys Res Commun. 2015,458(2):381-6. 14. Wang Y, Chen Y, Li S. An Investigation of Antibacterial Pretreatment Protocol for Primary Fibroblast Culture from Transbronchial Biopsies in Benign Tracheal Stenosis Patients. Chin J Respir Crit Care Med. 2015, 14(3):286-90 15. Wang J, Li S, Zeng Y, Chen P, Zhang N, Zhong N. 18F-FDG PET/CT is a valuable tool for relapsing polychondritis diagnose and therapeutic response monitoring. Ann Nucl Med. 2014,28(3):276-84 16. Wang J, Li S, Liu J, Gu Y, Chen P. Multiple pulmonary nodules with high metabolic activity: Potential benefit of multiple nodule biopsies by video-assisted thoracic surgery: A case report. Exp Ther Med. 2013;6(2):325-328. 17. Wang JL, Li SY, Luo YF, Zhai YP, Wei XQ. Changes of Th1/Th2 cytokines in immunocompetent patients with pulmonary cryptococcosis. Genet Mol Res. 2013 Nov 18;12(4):5733-42.