Risk Factors for Ruptured Uterus Among Patients at Khyber Teaching Hospital Peshawar
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Risk factors for ruptured uterus among patients at khyber teaching JKCD January 2020, Online Issue RISK FACTORS FOR RUPTURED UTERUS AMONG PATIENTS AT KHYBER TEACHING HOSPITAL PESHAWAR Gul e Rana1, Seema Gul2, Manya Tahir3, Hooria Rashid4, Heema5, Asma Ambreen1 1Department of Gynaecology and Obstetrics, Khyber Teaching Hospital, Peshawar. 2Department of Gynaecology and Obstetrics, Watim Medical and Dental College Rawalpindi. 3Department of Community Medicine, Watim Medical and Dental College Rawalpindi. 4Rehman Medical Institute, Hayatabad Peshawar. 5Department of Gynaecology and Obstetrics, KMU Institute of Medical Sciences Kohat, Khyber Pakhtunkhwa. Available Online 30-March 2020 at http://www.jkcd.edu.pk DOI: https://doi.org/10.33279/2307-3934.2020.0117 ABSTRACT Objective: To determine the risk factors for ruptured uterus among patients in our local population. Materials and Methods: This descriptive cross sectional study was carried out at Gynaecology and obstetrics department of Khyber Teaching Hospital Peshawar, on a sample size of 134, over a period of two years from 01-05-2016 to 31 April 2019. Results: Mean age of patients was found to be 27 years. Mean period of gestation was almost 38 weeks. Mean parity was found to be more than 4. Scarred uterus was found to be the main factor for uterine rupture, contributing for 70 % of the total patients with uterine ruptures. Obstructed labor was the next main factor making 15% of all the patients, whereas the rest of 15 % patients had uterine rupture because of injudicious use of prostaglandins and oxytocin. Conclusion: Scarred uterus is the main causative factor for rupture of a gravid uterus. Keywords: Ruptured Uterus, Caesarean Section, Obstructed Labor, Oxytocin, Prostaglandins INTRODUCTION interruption of the integrity of uterine wall after fetal viability has been established.4 This complication is According to World Health Organization, 810 women died every day from preventable causes unlikely to occur silently during pregnancy; how- related to pregnancy and child birth in the year ever it can occur silently in patients with previous 2017. Among these 94% of the deaths occurred in classical cesarean scar usually from the early first 5 women of lower middle and low income countries trimester. Uterine rupture (UR) has two types, Com- of African and South Asian population.1 Maternal plete UR involves the entire thickness of the uterine mortality in Europe and America is 12/100,000 live wall, resulting in connection between uterine and births while in Pakistan maternal mortality is very peritoneal cavity. Fetus and sometimes the placenta high 178 deaths/100,000 live births.2 are discharged into the peritoneal cavity. The Incom- 6 Uterine rupture is a complication of pregnancy plete UR is the one where the serosal coat is intact. associated with severe maternal and fetal morbidity According to WHO systemic review, the incidence and mortality.3 The term uterine rupture refers to of uterine rupture in general population is 5.3/10,000 7 Correspondence: births. The prevalence is variable, being rare in Dr. Gul e Rana developed countries due to increased antenatal and Ex Senior Registrar Department of Gynaecology and Obstet- intra-partum care.8 However this grave problem is rics, Khyber Teaching Hospital, Peshawar, Pakistan. Email: [email protected] more common in developing countries and countries Contact: 00447492327558 in transition mostly because of ignorance, quackery, Available Online 30-March 2020 at http://www.jkcd.edu.pk DOI: https://doi.org/10.33279/2307-3934.2020.0117 1 Risk factors for ruptured uterus among patients at khyber teaching JKCD January 2020, Online Issue mal-distribution, maladministration, non-availability uterine rupture as studies on the subject are scarce in of essential medical supplies and lack of access to our setup. The results are shared with gynecologists antenatal and intra-partum care.9 and obstetricians and suggestions are made for timely and proper management of patients who are exposed In high income countries, ruptured uterus occurs to the risk factors for ruptured uterus. because of poorly supervised labor in scarred uter- us.10 Reported rates of uterine rupture in women with MATERIALS AND METHODS previous lower segment cesarean section in United A descriptive cross-sectional study was con- Kingdom depend upon whether the trail of labour ducted in Obstetrics and Gynecology Department, is spontaneous (0.15–0.4%), induced (0.54–1.4%) Khyber Teaching Hospital, Peshawar, over a period or augmented (0.9–1.91%).11 Risk after classical of two years from 01-05-2016 to 31 April 2019. cesarean section is found to be 1-12%.12 Other risk A total of 134 patients were included in the study, factors include gynecological uterine surgeries, using 14.7%2 of previous uterine surgery, 95%con- e.g. Myomectomies, resection of uterine anomalies fidence interval and 6% margin of error, under WHO (Metroplasty), or uterine cornual resection. In low software for size determination. Non probability income countries, it mostly occurs in unscarred purposive sampling technique was used. All patients uterus from obstructed labour.8 However, in most of with ruptured uterus confirmed on ultrasonography cases, there is a combination of risk factors including and patients with a period of gestation of ≥ 28 weeks induction of labor, maternal age, height, body mass were included in the study. Uterine ruptures resulting index, education, smoking, gestational age, instru- from direct uterine trauma like motor vehicle acci- mental vaginal delivery, decreased inter-pregnancy dents or falls or violence like gunshot wounds were interval, abnormal placentation, invasive mole and excluded. These were the confounders and made the chorio-carcinoma.13 study results biased were excluded from the study. A very common event in the past, its incidence Permission was taken from the hospital ethical has greatly decreased in the recent years. Complete committee. Data was collected from all those pa- rupture with irreversible loss is rarely seen except in tients who were received with uterine rupture. An primitive communities which lack modern facilities informed written consent was taken from all the of health care.14 Consequences of uterine rupture patients or their relatives. A detailed history about the depend on the time that elapses from rupture until age, parity, and period of gestation, booking status, the institution of definitive treatment. The sooner the obstetrical and past surgical and medical history treatment is started; the better is the maternal as well were taken. Other details like history of mishandling as fetal outcome.14 by unskilled persons like over use of oxytocin or Pakistan like many other developing countries prostaglandins were noted. Examination including of the world is struggling with poor indicators of general physical examination, abdominal and vaginal reproductive health. In Pakistan, maternal mortality examination was done. Friendly environment was is 178/100,000 live births. Uterine rupture accounts provided to collect the accurate data. 1-13% of maternal and 74-92% of perinatal deaths.15 All the ultrasounds were done through expert Uterine rupture is a serious happening in the life sonologist and strictly exclusion criteria was fol- of a woman. It may not only endanger her life but lowed so that to control confounders and bias in our may even affect her future fertility.16 Uterine rupture study results. accounts for peri-partum hysterectomy in 42% of the All collected information was analyzed via soft- cases in a study conducted in Pakistan.17 ware SPSS version 10. Means +standard deviations The escalating caesarean section rate in develop- were calculated for continuous variables e.g. age, ing countries, inappropriate use of oxytocin / instru- parity. Proportions and frequencies were calculated mentation and obstructed labor due to unsupervised for categorical variables like previous uterine surger- process of labor has led to emergence of this grave ies, injudicious use of oxytocin and prostaglandins, obstetrical problem. This has compelled me to carry and obstructed labor. Results were presented in the out this study to identify risk factors associated with form of tables. Available Online 30-March 2020 at http://www.jkcd.edu.pk DOI: https://doi.org/10.33279/2307-3934.2020.0117 2 Risk factors for ruptured uterus among patients at khyber teaching JKCD January 2020, Online Issue RESULTS Frequencies of patients with history of ob- structed labor in various age groups are shown in The study was conducted on 134 patients, who Table III. Only age group 31 – 35 had significant presented to us with ruptured uterus, and various number of patients with history of obstructed labor risk factors for the uterine rupture were found. The i.e. 11(37.9%) but most of the patients 18 (62.1%), patients were categorized in different groups on the even in this group had no history of obstructed labor. basis of various factors like age in years, parity and gestational age in weeks as shown in Table No I. Grouping of the patients according to their parity The mean age of the patients in the study was 27.14 is shown in Table IV. In this table the patients are years ±5.91SD from the mean. The eldest patient divided as nulliparous, with parity 1 – 3, 4 – 6, 7 – was 41 years old and the youngest was 16 years old. 9, and more than 9. Parity group of 1 – 3 had most The parity of the patients ranged from 0 – 11 with number of patients i.e. 53 (39.6%). There were 7 an average parity of was 4.56 ±3.19SD. The aver- (5.2%) nulliparous patients. Parity group 4 – 6 and age gestational age of the patients was 37.9 weeks 7 – 9 had significant number of patients, 36 (26.9%) with minimum of 28 weeks and the maximum of 42 and 27 (20.1%) respectively. 11 (8.2%) had parity weeks ±2.58SD.