COMMON DRUG NUTRIENT DEPLETIONS (DNDs) & INTERACTIONS (DNIs) DND – Use of certain medications may deplete key nutrients. DNI – Interactions with drugs and nutrients can affect drug effectiveness and nutrient absorption. ACID SUPPRESSING MEDICATIONS 2 1 ANTIBIOTICS1-3 & ANTACIDS1,3 DNDs DNIs DNDs DNIs
Potential Magnesium and Goldenseal, Ginger, & Potential B vitamins (B1, Separate any minerals and vitamin B12 depletions with Green Tea may interact B2, B6, Folic Acid, B12) probiotic supplements use of H2 antagonists with and/or affect drug depletions. from antibiotics by at least and/or Proton Pump effectiveness. 2 hours. inhibitors.
3 BIRTH CONTROL 4 BLOOD PRESSURE MEDICATION1-5 (Oral Contraceptives)1,3 DNDs DNIs DNDs DNIs
Folic Acid, B6, and Alfalfa, Garlic, St. John’s CoQ10 (Beta blockers), Black Licorice, Chromium, Magnesium levels may Wort may interact with Potassium, zinc and Milk Thistle, Niacin, St. be affected with and/or affect drug magnesium levels may be John’s Wort, and vitamin B6 medication use. effectiveness. affected (thiazide diuretics). may interact with and/or affect drug effectiveness. 5 BLOOD THINNING MEDICATION 6 CHOLESTEROL LOWERING MEDICATIONS (Anticoagulants)1 (Statins & Bile Acid Sequestrants)1-3 DNDs DNIs DNDs DNIs No major DNDs noted. CoQ10, Cranberry, Garlic, Statins may affect CoQ10; Garlic, Niacin, St. John’s Herbals, Fish Oil, and statins and bile acid Wort, Red Yeast Rice, and vitamins E & K may interact sequestrants may affect vitamin A may interact with and/or affect drug fat soluble vitamin with and/or affect drug effectiveness. (A,D,E,K) levels. effectiveness.
7 CORTICOSTEROIDS2,3 8 DIABETES MEDICATIONS (Metformin)1-3 DNDs DNIs DNDs DNIs Calcium and Magnesium Herbals, Licorice and Potential Folic Acid and Alfalfa, Aloe Vera, Alpha levels may be affected St. John’s Wort may vitamin B12 depletions. Lipoic Acid, CoQ10, with medication use. interact with and/or Chromium, Garlic, Green Tea, Melatonin, Milk affect drug effectiveness. Thistle, Niacin, St. John’s Wort, and vitamin K1 may interact with and/or affect drug effectiveness. Sources* 1. US National Library of Medicine. Drugs, Herbs and Supplements. Internet: https://www.nlm.nih.gov/medlineplus/druginformation.html Accessed 28 April 2016. 2. Meletis CD & Zabriskie N. Common nutrient depletions caused by pharmaceuticals. Alt Comp Ther 2007;13(1):10-17. 3. Hyla Cass, M.D. A Practical Guide to Avoiding Drug-Induced Nutrient Depletion: http://nutritionreview.org/2013/04/practical-guide-avoiding-drug-induced-nutrient-depletion/ 4. Clayton,JA, Rodgers S, Blakey J. Thiazide diuretic prescription and electrolyte abnormalities in primary care. Br J Clin Pharmacol 2006 Jan;61:87-95. ©2016 Pharmavite LLC 5. Pak CY. Correction of thiazide-induced hypomagnesemia by potassium-magnesium citrate from review of prior trials. Clin Nephrol 2000;54:271-275. PID13168 *Additional references available upon request.