High Performance Zinc for Nutrition & Immunity

Home , Mineral (nutrient), Zinc gluconate

Zinc 30 Zn 65.409

Bioavailable 100% Pure & Ultra Low Levels High Zinc Chelates Fully Reacted of Pb/Cd/As/Hg Content

Zinc for capsules, gelcaps, gummies, liquids, lozenges, tablets and powders.

Zinc Acetate Zinc Lactate Zinc Citrate Dihydrate Zinc Oxide Zinc Gluconate Zinc Phosphate Zinc Glycinate Zinc Sulfate Fully Reacted High Purity Jost mineral salts are fully reacted. The process for It is common to find higher levels of lead in zinc products manufacturing fully reacted pure salts involves the reac- because they are found in the same ore deposits. This tion of an acid and a base in an aqueous solution and the can make sourcing zinc salts with lead levels of < 1 ppm precipitation of a salt compound. Dissolving the reactants extremely difficult. Jost has a process to manufacture low provides the opportunity for a complete reaction to occur. lead Zinc. Jost products meet the heavy metal require- The use of mineral salts containing unreacted com- ments of ICH Q3, California Prop 65, USP <232> Elemen- pounds can lead to: tal Impurities, and The European Regulation No. 629/2008 Formulation stability problems (amending 1881/2006). Inaccurate ingredient declarations on the finished product label Arsenic (as As) 1 ppm maximum Post blending issues Cadmium (Cd) 1 ppm maximum Tablet issues Lead (as Pb) 1 ppm maximum Human consumption / Digestion / Absorption issues Packaging issues Mercury (Hg) 0.1 ppm maximum

Bioavailability Jost manufactures several 100% pure chelates (listed Committed to Quality for more than 35 years below), which can be readily verified for identity, purity, > Manufacturing in the United States and Europe and potency. Chelated minerals are often a preferred > In-house tested choice by nutritionists because their complex struc- > USP/EP/FCC mineral salts tures better survive passage through the stomach to the small intestine where absorption into the blood- > cGMPcompliant, FDA-registered facilities stream occurs. Jost Zinc chelates: > Consistent from lot-to-lot and meet all customer Zinc Bisglycinate Monohydrate requirements Zinc Citrate Dihydrate > Provide particle size options Zinc Gluconate > Custom product development and technical support Zinc Lactate Dihydrate > Traceability from raw material to end product

Jost Chemical is a leading manufacturer of high purity mineral salts. We manufacture and test everything we sell.

High Performance Zinc Ready-to-Drink Beverages

Clear Beverages/Liquid Application For ready-to-drink clear beverages, we suggest water soluble zinc salts. Choose zinc salts based on solubility and zinc content needed for formulation. Zinc Acetate Dihydrate is very soluble and also has high zinc content. Avoid using with soluble citrates at a pH > 4.5. Avoid using with soluble phosphates at a pH > 2.5.

Shakes and Liquids with Insoluble Components Typically insoluble zinc salts are recommended for ready- to-drink shakes, but water soluble salts can also be used. Powders can also be used for this application.

SOLUBLE SALTS SOLUBILITY %2,3 ZINC CONTENT % TASTE4

Zinc Acetate Dihydrate 45 29.2 - 30.4 Mild Metallic, Acidic Taste

Zinc Bisglycinate Monohydrate 5 27 min Mild Metallic, Strong Aminic Taste

Zinc Gluconate Hydrate5 13 12.3-14.6 Mild, Faint Taste

Zinc Lactate Dihydrate 1.7-17100 22.0-24.0 Mild, Faint Taste

Zinc Sulfate Heptahydrate 36.7 22.5-24.7 Strong After Taste, Hurts Tongue, Sour

Zinc Sulfate Monohydrate 36.7 36.1-36.6 Exothermic, Biting, Bitter

INSOLUBLE SALTS

Zinc Citrate Dihydrate Slightly Soluble 31.3-32.1 Neutral Zinc Phosphate Tribasic Insoluble 41.9-43.7 Neutral Tetrahydrate Zinc Oxide Low Pb Insoluble 78.7-80.7 Neutral

1. Generally arranged by descending solubility and increasing metal content. 4. Taste profiles developed by Jost personnel and are subjective. 2. Solubility in percent. Superscript is temperature; if no superscript, 25°C. 5. Jost’s Zinc Gluconate is typically a dihydrate. 3. CRC Handbook and Merck Index are the main sources of this information.

High Performance Zinc Powder Pre-mixes

Water soluble zinc salts are ideal for powder pre-mixes for clear beverages. Insoluble zinc salts can also be used for shakes. Zinc Acetate Dihydrate is very soluble and also has high zinc content. Caution when using with soluble citrates when reconstituted formulation has a pH > 4.5 to avoid post precipitation. Caution when using with soluble phosphates when reconstituted formulation has a pH > 2.5. Watch pH <7 with citrates, sulfates and phosphates.

SOLUBLE SALTS SOLUBILITY %2,3 ZINC CONTENT % TASTE4

Zinc Acetate Dihydrate 45 29.2 - 30.4 Mild Metallic, Acidic Taste

Zinc Bisglycinate Monohydrate 5 27 min Mild Metallic, Strong Aminic Taste

Zinc Gluconate Hydrate5 13 12.3-14.6 Mild, Faint Taste

Zinc Lactate Dihydrate 1.7-17100 22.0-24.0 Mild, Faint Taste

Zinc Sulfate Heptahydrate 36.7 22.5-24.7 Strong After Taste, Hurts Tongue, Sour

Zinc Sulfate Monohydrate 36.7 36.1-36.6 Exothermic, Biting, Bitter

INSOLUBLE SALTS

Zinc Citrate Dihydrate Slightly Soluble 31.3-32.1 Neutral Zinc Phosphate Tribasic Insoluble 41.9-43.7 Neutral Tetrahydrate Zinc Oxide Low Pb Insoluble 78.7-80.7 Neutral

High Performance Zinc Tablets

Tablets need product with good flowability, higher bulk density, higher mineral content and decent compress- ibility profiles. Zinc Acetate Dihydrate and Zinc Citrate Dihydrate are recommended options.

SALT1 SOLUBILITY %2,3 ZINC CONTENT % TASTE4

Zinc Acetate Dihydrate 45 29.2 - 30.4 Mild Metallic, Acidic Taste

Zinc Gluconate Hydrate5 13 12.3-14.6 Mild, Faint Taste

Zinc Citrate Dihydrate Slightly Soluble 31.3-32.1 Neutral Zinc Phosphate Tribasic Insoluble 41.9-43.7 Neutral Tetrahydrate

Capsules

Capsules need product with good flowability, higher bulk density and higher mineral content. High mineral content and high density is ideal for smaller capsules.

SALT1 SOLUBILITY %2,3 ZINC CONTENT % TASTE4

Zinc Acetate Dihydrate 45 29.2 - 30.4 Mild Metallic, Acidic Taste

Zinc Citrate Dihydrate Slightly Soluble 31.3-32.1 Neutral Zinc Phosphate Tribasic Insoluble 41.9-43.7 Neutral Tetrahydrate Zinc Oxide Low Pb Insoluble 78.7-80.7 Neutral

High Performance Zinc Gel Caps

Gel Caps need product with low bulk density, and decent oil dispersion characteristics. Typically, highly crystalline salts do not work well in this application.

SALT1 SOLUBILITY %2,3 ZINC CONTENT % TASTE4

Zinc Citrate Dihydrate Slightly Soluble 31.3-32.1 Neutral Zinc Phosphate Tribasic Insoluble 41.9-43.7 Neutral Tetrahydrate Zinc Oxide Low Pb Insoluble 78.7-80.7 Neutral

Gummies & Lozenges

Water soluble Zinc salts that are heat /shear stable are recommended for gummies and lozenges. Zinc Acetate Dihydrate is an excellent choice and will produce a clear product. Avoid using with soluble citrates at a pH > 4.5 to avoid post precipitation. Avoid using with soluble phosphates at a pH > 2.5. Zinc Citrate is a good choice for gummies that are not required to be clear. Zinc Gluconate is a popular choice for lozenges.

SALT1 SOLUBILITY %2,3 ZINC CONTENT % TASTE4

Zinc Acetate Dihydrate 45 29.2 - 30.4 Mild Metallic, Acidic Taste

Zinc Bisglycinate Monohydrate 5 27 min Mild Metallic, Strong Aminic Taste

Zinc Gluconate Hydrate5 13 12.3-14.6 Mild, Faint Taste

Zinc Citrate Dihydrate Slightly Soluble 31.3-32.1 Neutral

Zinc Lactate Dihydrate 1.7-17100 22.0-24.0 Mild, Faint Taste

Zinc Sulfate Monohydrate 36.7 36.1-36.6 Exothermic, Biting, Bitter

High Performance Zinc Health Benefits of Zinc Zinc Applications The trace mineral zinc is essential for body growth, Dietary supplement maturation and development, as well as tissue repair and Clinical applications resistance to disease. Zinc is an important mineral for children and the elderly. Zinc is involved in numerous Animal nutrition aspects of cellular metabolism. It is required for the Cold remedies catalytic activity of approximately 100 enzymes, and it plays a role in immune function, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc also sup- Jost Zinc Product Offerings ports normal growth and development during pregnancy, Zinc Acetate Dihydrate childhood, and adolescence and is required for proper sense of taste and smell. Zinc Ascorbate Zinc Bisglycinate Zinc supplementation has been used to help with: Zinc Sulfate Monohydrate Immune function Zinc Sulfate Heptahydrate Wound healing Zinc Gluconate Hydrate Tissue growth Zinc Lactate Dihydrate Diarrhea Zinc Citrate Dihydrate The common cold Zinc Phosphate Fertility and reproduction Zinc Oxide Age-related macular degeneration

Groups at Risk of Zinc Inadequacy Zinc RDA People with gastrointestinal and other diseases Zinc is an essential mineral that must be absorbed in small amounts to keep humans healthy. A daily intake of Vegetarians zinc is required to maintain a steady state because the Pregnant and lactating women body has no specialized zinc storage system. Older infants who are exclusively breastfed People with sickle cell disease Age Male Female Pregnancy Lactation Alcoholics

0–6 months 2 mg* 2 mg*

7–12 months 3 mg 3 mg

1–3 years 3 mg 3 mg

4–8 years 5 mg 5 mg

9–13 years 8 mg 8 mg

14–18 years 11 mg 9 mg 12 mg 13 mg

19+ years 11 mg 8 mg 11 mg 12 mg * Adequate Intake (AI)

(Internet source: National Institutes of Health; Office of Dietary Supplements and references there-in, EU Register of nutrition and health claims made on foods)

High Performance Zinc North America, Latin America, Asia/Pacific and China [email protected] +1 314 428 4300

Europe, Middle East and Africa [email protected] +32 85 552 655 jostchemical.com

The information provided is based, in part, on publicly available information that we have not independently verified and is subject to change. We undertake no obligation to notify customers of any such change. Customers are solely responsible for confirming that their uses/applications of Jost products, including on labels and other marketing materials, comply with applicable law. Recipients of this information and recommendations must make their own determination as to its suitability for their purposes. In no event shall Jost assume liability for damages or losses of any kind of nature that result from the use of or reliance upon this information and recommendations.