Structure Matters
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Measurement and Interpretation of Diffuse Scattering in X-Ray Diffraction for Macromolecular Crystallography
Measurement and Interpretation of Diffuse Scattering in X-Ray Diffraction for Macromolecular Crystallography Workshop at the 2017 NSLS-II and CFN Users’ Meeting, Brookhaven National Laboratory, Upton, NY, May 15, 2017 Organizers: Michael Wall, [email protected] (LANL), Robert Sweet, [email protected] (NSLS-II, BNL), Nozomi Ando, [email protected] (Princeton University), James S. Fraser, [email protected] (University of California, San Francisco), George N. Phillips, Jr., [email protected] (Rice University) X-ray diffraction from macromolecular crystals includes both sharply peaked Bragg reflections and diffuse intensity between the peaks. The information in Bragg scattering reflects the mean electron density in the unit cells of the crystal. The diffuse scattering arises from correlations in the variations of electron density that may occur from one unit cell to another, and therefore contains information about collective motions in proteins. Leading researchers in diffuse scattering gathered May 15, 2017 for a one-day workshop at the NSLS-II Users’ Meeting. A major focus of the workshop was to provide a roadmap to the acquisition of reliable data by surveying measurement methods and discussing the increase in measurement accuracy enabled by improved detectors, experimental methods, and data integration. Another major focus was to survey examples of information that can be extracted about the behavior of biomolecules that would guide the thinking of biochemists and biologists. A number of talks addressed the measurement of diffuse-scattering data and advances in the modeling of the data in terms of conformational variation. Below we give a short synopsis of each talk, and at the end an analysis of the results of the workshop in total. -
Livro De Resumos Livro De Resumos
LivroLivro dede ResumosResumos 12 a 17/Nov, 2017, Águas de Lindóia/SP, Brasil 1 Livro.indd 1 31/10/2017 15:39:53 Apoio Patrocínio 2 Livro.indd 2 31/10/2017 15:40:03 Sumário Apoio 2 Patrocínio 2 Boas Vindas 5 Comitê Organizador 7 Comitê Científico 7 Programa Científico 9 Domingo (12/11) 10 Segunda-feira (13/11) 10 Terça-feira (14/11) 13 Quarta-feira (15/11) 16 Quinta-feira (16/11) 17 Sexta-feira (17/11) 19 Resumo das Plenárias 20 Resumo das Palestras 32 Resumo das Comunicações Orais 71 Lista dos trabalhos apresentados na forma de painel 104 Segunda-feira (13/11) das 20h00 às 22h00 106 Terça-feira (14/11) das 20h00 às 22h00 113 Resumo das Painéis 119 Lista dos participantes 629 3 Livro.indd 3 31/10/2017 15:40:03 4 Livro.indd 4 31/10/2017 15:40:03 Boas Vindas: Sejam bem vindos ao XIX Simpósio Brasileiro de Química Teórica! Esta é a décima nona edição do SBQT (http://www.sbqt2017.if.usp.br) e ocorre no Hotel Majestic em Água de Lindoia no período de 12 a 17 de novembro de 2017. Neste evento reunimos cerca de 380 participantes, o que representa uma parte considerável da comunidade de Química Teórica e Física Atômica e Molecular do Brasil. Esta edição envolve 57 instituições de ensino e pesquisa, com uma distribuição regional de 5% do Norte, 15% do Nordeste, 14% do Centro-Oeste, 63% do Sudeste e 14% do Sul. Sendo os seguintes estados do Sudeste os que têm mais participantes: São Paulo (27%), Minas Gerais (19%) e Rio de Janeiro (16%). -
Brief Newsletter from World Scientific October 2017
Brief Newsletter from World Scientific October 2017 World Scientific Publishing Proudly Presents Publication Paying Tribute to 1999 Nobel Laureate Ahmed Zewail Personal and Scientific Reminiscences Tributes to Ahmed Zewail Edited by: Majed Chergui (École Polytechnique Fédérale de Lausanne, Switzerland), Rudolph A Marcus (Caltech), John Meurig Thomas (Cambridge), Dongping Zhong (The Ohio State University, USA) This volume is a compilation of wonderful tributes to the late Ahmed Zewail (1946- 2016), who is widely considered the 'Father of Femtochemistry'. Largely composed of testimonies by friends and relatives of Zewail and outstanding scientists from around the world who have worked with or were affiliated with the Nobel laureate, this book further embellishes his reputation as an icon in the field of physical chemistry and the father of ultra fast electron-based methods. Individual contributions describe the author's own unique experience and personal relationship with Zewail and includes details of his scientific achievements and the stories surrounding them. Personal and Scientific Reminiscences collects accounts from some of the most important figures in the physical and chemical sciences to give us unique insight into the world and work of one of the greatest scientists of our time. A book not to be missed by students, practitioners and researchers working with chemistry, physical chemistry and physics as well as readers with an interest in the history of science. http://www.worldscientific.com/worldscibooks/10.1142/Q0128 Significant -
CV Majed Chergui 2020
Curriculum Vitae of Majed CHERGUI Born 8.5.1956 in Casablanca (Morocco), Swiss and French citizen Married, three children born 1981, 1988 and 1990 Laboratoire de Spectroscopie Ultrarapide (LSU) and Lausanne Centre for Ultrafast Science (LACUS), Ecole Polytechnique Fédérale de Lausanne (EPFL), Faculty of Basic Sciences, ISIC CH H1 625, Station 6, CH-1015 Lausanne, Switzerland. Phone: ++41-21-693 0457/2555 (office); ++41-76-569 5566 (cell), Fax:++-41-21-693 0365 [email protected]; http://lsu.epfl.ch; http://LACUS.epfl.ch Higher Education 1977 Chelsea College, University of London. BSc. in Physics and Mathematics 1978 Université Paris-Sud, Orsay. MSc in Atomic and Molecular Physics 1981 Université Paris-Sud, Orsay. PhD in Physics. Supervisor : Professor Jacques Bauche 1986 Université Paris-Nord, Villetaneuse. Doctorat d'État (Habilitation) in Physics. Supervisor : Professor Venkataraman Chandrasekharan 1987-1988 Postdoc at the Physics Dept of the Freie Universität Berlin. Supervisor : Professor Nikolaus Schwentner. Professional experience 1980-1982 Assistant lecturer of Physics (Université Paris-Nord) 1982-1990 Research assistant at the National Centre for Scientific Research (C.N.R.S) at Univ. Paris-Nord, then Univ. Paris-sud 1987-1988 Fellow of the Alexander von Humboldt Foundation at the Freie Universität Berlin (Germany). 1990-1993 Senior research Assistant at the Inst. for Experimental Physics of the Freie Universität Berlin 1993-2003 Full Professor of Experimental Condensed Matter Physics at the Université de Lausanne (Switzerland) 1996 Guest Professor, National University of Quilmes-Buenos Aires (Argentina) 1999-2000 Research Associate, American University of Beirut (Lebanon) 2003- Professor of Physics and Chemistry, Ecole Polytechnique Fédérale de Lausanne, Switzerland 2009-2010 Guest A. -
Mathematical Virology Reidun Twarock
INFERENCE / Vol. 5, No. 3 Mathematical Virology Reidun Twarock ymmetry is ubiquitous in nature. It occurs in icosahedron from, 4, 8, and 20 equilateral triangles, respec- snowflakes, crystals, and molecules; and it is cen- tively. tral to our understanding of subatomic particles. Both the icosahedron and its dual, the dodecahedron, SAlthough the importance of symmetry in chemistry and possess icosahedral symmetry, and together they com- physics is widely appreciated, its significance in biology prise the largest rotational symmetry group in three is often underestimated. Viruses are notable examples of dimensions.3 Given a set of identical building blocks biological systems in which symmetry plays a pivotal role. under a repeating pattern of assembly, it is an icosahe- Mathematical techniques directed at understanding their drally symmetric shape that optimizes container volume. structure and symmetry have a transformative potential Since viruses are under selective pressure to package their both within virology and biology as a whole. genetic material efficiently, it is no surprise that evolution has forced their convergence to icosahedrally symmetric iral genomes are packaged in protein containers shapes. known as viral capsids. These containers function like Trojan horses, facilitating the release of the nlike other types of rotational symmetries in viralV genome into host cells and providing protection from three dimensions, icosahedral symmetry is non- host defense mechanisms between rounds of infection. In crystallographic: it is not possible to tessellate a their simplest form, viral capsids are less than 20 nano- Uthree-dimensional physical space using a single icosahe- meters (nm) in diameter and encapsulate short genomic drally symmetric shape without creating gaps or overlaps. -
Physics of Viral Dynamics
REVIEWS Physics of viral dynamics Robijn F. Bruinsma1, Gijs J. L. Wuite2 and Wouter H. Roos 3 ✉ Abstract | Viral capsids are often regarded as inert structural units, but in actuality they display fascinating dynamics during different stages of their life cycle. With the advent of single-particle approaches and high-resolution techniques, it is now possible to scrutinize viral dynamics during and after their assembly and during the subsequent development pathway into infectious viruses. In this Review, the focus is on the dynamical properties of viruses, the different physical virology techniques that are being used to study them, and the physical concepts that have been developed to describe viral dynamics. Capsids Humans and other animals, as well as plants, are plagued and new methods of analysis and numerical modelling. Protein shells that surround the by infections caused by viruses. These are parasites that We first review some of the dynamic methods that viral genome. cannot reproduce by themselves and that are incapable are being applied to study the assembly of empty viral of metabolic activity. Instead, after viruses infect cells, capsids, then focus on the role of genome molecules Triangulation numbers Classification system, they alter cellular molecular machinery so that it pro- (RNA/DNA) during assembly, followed by a discussion developed by Caspar and duces new viruses, which are then released into the envi- of studies of the steady-state dynamics of assembled Klug, for icosahedral viruses. ronment. This sequence of events, the viral life cycle, is viruses. BOx 2 summarizes several experimental tech- T-numbers are integers and schematically discussed in BOx 1. -
DNA Could Trap Viruses Irfan* Department of Microbiology, King Saud University, Saudi Arabia
& Bioch ial em OPEN ACCESS Freely available online b ic ro a c l i T M e f c h o n l o a Journal of n l o r g u y o J ISSN: 1948-5948 Microbial & Biochemical Technology Short Communication DNA could trap viruses Irfan* Department of Microbiology, King Saud University, Saudi Arabia INTRODUCTION also be used as a type of "virus trap." If they we have a tendency tore to be coated with virus-binding molecules at the inside, they have To date, there aren't any powerful antidotes towards maximum to be prepared to bind viruses tightly and consequently be capable virus infections. Scientists have now evolved a brand new approach: of take them out of circulation. For this, however, the hole our they engulf and neutralize viruses with nano-pills tailor-made from bodies might even should very own sufficiently large openings thru genetic cloth the use of the DNA origami method. The approach that viruses gets into the shells. has already been examined towards hepatitis and adeno-related viruses in mobileular cultures. It might also show a hit towards "None of the gadgets that we had engineered victimization corona viruses. deoxyribonucleic acid artwork generation at that factor might were prepared to engulf a whole virus -- they had been simply too small," There are antibiotics towards risky bacteria, but few antidotes to deal with acute infectious agent infections. Some infections can says Hendrik Dietz in retrospect. "Building solid hole our bodies of be averted via way of means of vaccination however growing new this length changed into a huge challenge. -
Photoinduced Structural Dynamics of Molecular Systems Mapped by Time-Resolved X-Ray Methods Majed Chergui, Eric Collet
Photoinduced Structural Dynamics of Molecular Systems Mapped by Time-Resolved X-ray Methods Majed Chergui, Eric Collet To cite this version: Majed Chergui, Eric Collet. Photoinduced Structural Dynamics of Molecular Systems Mapped by Time-Resolved X-ray Methods. Chemical Reviews, American Chemical Society, 2017, 117 (16), pp.11025-11065. 10.1021/acs.chemrev.6b00831. hal-01559760 HAL Id: hal-01559760 https://hal.archives-ouvertes.fr/hal-01559760 Submitted on 10 Jul 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Photoinduced structural dynamics of molecular systems mapped by time-resolved x-ray methods Majed Chergui*,† and Eric Collet*,‡ †Ecole Polytechnique Fédérale de Lausanne, Laboratoire de Spectroscopie Ultrarapide (LSU), ISIC, and Lausanne Centre for Ultrafast Science (LACUS), Faculté des Sciences de Base, Lausanne CH-1015, Switzerland. ‡ Univ Rennes 1, CNRS, Institut de Physique de Rennes, UMR 6251, UBL, F-35042 Rennes, France. ABSTRACT: We review the tremendous advances in ultrafast X-ray science, over the past 15 years, making the best use of new ultrashort x-ray sources including table-top or large-scale facilities. Different complementary x-ray based techniques, including spectroscopy, scattering and diffraction, are presented. -
Abstracts of Special Session Presentations Biology of Plant Pathogens
Abstracts of Special Session Presentations Biology of Plant Pathogens Aquatic Plant Pathology Development of an indigenous pathogen for management of the submersed freshwater macrophyte Hydrilla verticillata. J. F. SHEARER. Fungal pathogens: Their role in the ecology of floating and submerged U.S. Army Corps of Engineers, Research and Development Center, freshwater plants. R. CHARUDATTAN. Plant Pathology Dept., University Vicksburg, MS. Phytopathology 95:S120. Publication no. P-2005-0003-SSA. of Florida, Gainesville, FL. Phytopathology 95:S120. Publication no. P-2005- Hydrilla verticillata 0001-SSA. (L.f.) Royle (hydrilla) is considered one of the three most important aquatic weeds in the world. Plant infestations can impede navi- Freshwater plants encompass a diverse group of morphologically and gation, clog drainage or irrigation canals, affect water intake systems, interfere taxonomically dissimilar plants adapted to life in a highly unstable habitat. with recreational activities, and disrupt wildlife habitats. The plant is an These plants can be emergent and free-floating, emergent and rooted, fully excellent competitor in aquatic habitats because it can photosynthesize at low submerged and free-floating, or fully submerged and rooted. A variety of light levels, has wide environmental tolerances, and produces several types of fungi in the Oomycota, Chytridiomycota, Anamorphic fungi, Ascomycota, extended survival propagules. The indigenous fungal pathogen, Mycolepto- and Basidiomycota cause diseases on these plants. While pathogenic fungi can discus terrestris (Gerd.) Ostazeski, (Mt) has shown significant potential for regulate plant population density by limiting plant growth and seedling use as a bioherbicide for management of hydrilla. Liquid fermentation recruitment, opportunistic parasites accelerate senescence of older growth and methods have been developed and patented that yield stable, effective recycle nutrients from dead tissues. -
MTPR-010 Late Head Physics Dept., Cairo University MTPR-010 Haris Rashid, CHEP, Punjab Univ., PAKISTAN PROGRAM CHAIR Howard Taylor
· Plasma physics CCAALLLL ffoorr PPAAPPEERRSS Pierre Jeagley, Orsay University, FRANCE UNDER THE PATRONAGE OF Prof. Dr. Hosam Kamel INVITED SPEAKERS A. Douhal, Castilla La Mancha Univ., SPAIN ttthh President Cairo University TThhee 44 Prof. Dr. Hussein Khalid Ahmed Azzawi, Nuc. Energy Centre, ARGENTINA Vice President of Cairo University for Research Studies Annie Klisnick, Paris-Sud University, FRANCE IInntteerrnnaattiioonnaall CCoonnffeerreennccee Andreas Becker, Max-Planck Inst., GEMANY HONORARY CHAIRMAN Anthony J. Leggett, Illinois Univ., USA oonn Prof. Ahmed Zewail A. Ya Faenov, RAS, Moscow Univ., RUSSIA NOBEL PRIZE LAUREATE 1999 Ayub Faridi, Punjab Univ., PAKISTAN MMooddeerrnn TTrreennddss IInn PPhhyyssiiccss Linus Pauling Chair Professor of Chemistry and Professor Bahaa Saleh, Boston Univ., USA of Physics Research Catherine Brechignac, CNRS, FRANCE Research CHAIRMAN Chang Hee Nam, KAIST, SOUTH KOREA Prof. Dr. Ahmad Helmy Galal David Ros, LASERIX, FRANCE Dean Faculty of Science, Cairo University D. Weaire, Trinity College Dublin, IRLAND Enam Chowdhury, Ohio State Univ., USA VICE CHAIRMEN Fazal-e-Aleem, CHEP, Punjab Univ., PAKISTAN Prof. Dr. Gamal Abdel Naser Madbouly Feras Afaneh, Hashemite Univ., JORDAN Head Physics Dept., Cairo University Gilles Renaud , CEA,, FRANCE Prof. Dr. Hossam EL Din Hamed Hasan Hani El Sayed, Commonwealth Univ., USA MTPR-010 Late Head Physics Dept., Cairo University MTPR-010 Haris Rashid, CHEP, Punjab Univ., PAKISTAN PROGRAM CHAIR Howard Taylor. South California Univ., USA Prof. Dr. Lotfia El Nadi, Jai -
L'oreal Foundation Annual Report
2015 L’OREAL FOUNDATION ANNUAL REPORT /6 2015 L’ORÉ AL FOUNDATION ANNUAL REPORT SCIENCE BEAUTY /4 CONTENTS MESSAGE FROM THE CHAIRMAN P. 7 BOARD OF DIRECTORS P. 8 ABOUT THE FOUNDATION P. 10 THE FOUNDATION’S PARTNERS P. 11 SCIENCE NEEDS WOMEN P. 12-27 - L’Oréal-UNESCO For Women in Science programme - 2015 L’Oréal-UNESCO Awards Laureates - 2015 International Jury in Physical Sciences - 2015 International Rising Talents - For Women in Science Fellowships - For Girls in Science programme - #ChangeTheNumbers BEAUTY TO FEEL BETTER AND TO LIVE BETTER P. 28-37 - International vocational training in the beauty sector - Beauty care in medical and social contexts - Operation Smile CITIZEN TIME P. 39 KEY FIGURES P. 40 /5 /6 THE L’ORÉAL FOUNDATION HAS GREAT AMBITIONS In supporting two important causes, Science and Philanthropic Beauty, the L’Oréal Foundation has set itself ambitious, far-reaching and virtuous goals. We know these two fields well, since they have been linked to our history and expertise for over a century. Thanks to the effective partnerships it has built around the world, the Foundation is able to use its expertise to meet the needs of people on the ground. Making a real difference means being committed to our projects. This implies consistency, regularity and determination. Since its creation in 2007, the L’Oréal Foundation has been committed to long-term actions, helping us to establish a strategy of support and solidarity. We approach our philanthropic work with the same rigor and skill we apply to our business dealings. Our For Women in Science programme not only supports and recognizes the women who are driving scientific progress, but through its magnificent work in the field with high school students, its For Girls in Science initiative is responding to the crisis in the number of women embarking on scientific careers. -
Curriculum Vitae of Prof. Majed CHERGUI
Curriculum Vitae of Prof. Majed CHERGUI Born 8.5.1956 in Casablanca (Morocco), Swiss and French citizen Married, three children born 1981, 1988 and 1990 Laboratory of Ultrafast Spectroscopy, Ecole Polytechnique Fédérale de Lausanne (EPFL), Faculty of Basic Sciences, ISIC CH H1 625, Station 6, CH-1015 Lausanne, Switzerland. Phone: ++41-21- 693 0457/0447, Fax: ++-41-21- 693 0365 [email protected]; http://lsu.epfl.ch Higher Education 1977 Chelsea College, University of London. BSc. in Physics and Mathematics 1978 Université Paris-Sud, Orsay. MSc in Atomic and Molecular Physics 1981 Université Paris-Sud, Orsay. PhD in Physics 1986 Université Paris-Nord, Villetaneuse. Doctorat d'État (Habilitation) in Physics Professional experience 1980-1982 Assistant lecturer of Physics (Université Paris-Nord) 1982-1990 Research assistant at the National Centre for Scientific Research (C.N.R.S) at Univ. Paris-Nord, then Univ. Paris-sud 1987-1988 Fellow of the Alexander von Humboldt Foundation at the Freie Universität Berlin (Germany) 1990-1993 Senior research Assistant at the Inst. for Experimental Physics of the Freie Universität Berlin 1993-2003 Full Professor of Experimental Condensed Matter Physics at the Université de Lausanne (Switzerland) 1996 Guest Professor, National University of Quilmes-Buenos Aires (Argentina) 1999-2000 Research Associate, American University of Beirut (Lebanon) 2009-2010 Guest Professor, Max-Born-Institut and Helmholtz-Zentrum (Berlin, Germany) 2003- Professor of Physics and Chemistry, Ecole Polytechnique Fédérale de Lausanne, Switzerland Honours Studentship of the British Council for Best Results 1975-1977 (UK) Lauréat de la Fondation de France 1979 (France) Medal of the C.N.R.S.