JOURNAL OF CLINICAL MICROBIOLOGY VOLUME 13 * NUMBER 2 * 1981 EDITORIAL BOARD Henry D. Isenberg, Editor-in-Chief (1984) Nathalie J. Schmidt, Editor (1985) Long Island Jewish-Hillside Medical Center, California Department of Health, New Hyde Park, N. Y. Berkeley, Calif Herman Friedman, Editor (1985) College ofMedicine Peter B. Smith, Editor (1984) University of South Florida Centerfor Disease Control, Tampa, Fla. Atlanta, Ga. Michael R. McGinnis, Editor (1985) North Carolina Memorial Hospital Chapel Hill, N.C. Donald G. Ahearn (1981) Dieter Groschel (1983) Robert H. Purcell (1983) Libero Ajelo (1982) Peter A. Gross (1983) Paul G. Quie (1983) William L. AMbritton (1981) Pekka Halonen (1981) William E. Rawls (1983) James R. Allen (1982) James L. Hardy (1981) L. Barth Relier (1983) Stephen D. Allen (1981) Maurice W. Harmon (1982) Shirley J. Richmond (1982) Daniel Amsterdam (1983) William J. Hausler, Jr. (1981) Glenn D. Roberts (1983) Lawrence Ash (1983) George R. Healy (1983) Jon E. Rosenblatt (1983) Arthur L. Barry (1981) Kenneth L. Herrmann (1982) Arthur F. Rosenthal (1982) Barry Beaty (1981) Lillian V. Holdeman (1982) R. S. Ross (1983) John F. Bennett (1982) Milton Huppert (1981) Sally Jo Rubin (1983) E. L. Bieberstein (1983) Russell C. Johnson (1982) Julius Schachter (1983) Victor D. Bokkenhauser (1982) Wallace L. Jones (1983) Alexis Shelokov (1982) Edward J. Bottone (1983) S. S. Kalter (1981) Marcelino F. Sierra (1981) Don J. Brenner (1983) Leo Kaufman (1981) Margarita Silva-Hutner (1983) Sotiros D. Chaparas (1982) Douglas S. Kellogg (1981) Robert M. Smibert 11(1981) William B. Cherry (1981) George E. Kenny (1982) James W. Smith (1983) Waflace A. Clyde, Jr. (1982) Wesley E. Kloos (1982) Leslie Spence (1982) B. H. Cooper (1983) George P. Kubica (1982) Daniel P. Steites (1983) Richard F. D'Amato (1983) Walter J. Loesche (1982) Vera L. Sutter (1982) Jules L. Dienstag (1983) James D. MacLowry (1983) Jason Tanzer (1982) Richard E. Dixon (1981) William J. Martin (1983) Patricia E. Taylor (1982) Steven D. Douglas (1981) Laurence R. McCarthy (1983) Welton 1. Taylor (1983) Walter R. Dowdle (1982) Joseph E. McDade (1982) John H. Thompson, Jr. (1983) Bennett L. Elisberg (1982) Jerry R. McGhee (1982) Clyde Thornsberry (1983) Richard W. Emmons (1983) Joseph L. Melnick (1982) Richard C. Tilton (1981) Richard Facklam (1982) William 1. Metzger (1983) Alexander von Graevenitz (1983) John C. Feeley (1983) Stephen A. Morse (1983) 1. Kaye Wachsmuth (1981) James D. Fenters (1982) C. Wayne Moss (1983) Kenneth W. Walls (1983) Patricia Ferrieri (1983) Maurice A. Mufson (1983) Joseph L. Waner (1983) Sydney M. Finegold (1982) Robert D. Nelson (1983) Lawrence G. Wayne (1983) Maxwell Finland (1983) Harold C. Neu (1982) Tracy D. Wilkins (1981) Lynn S. Garcia (1983) Joseph V. Osterman (1982) Hazel Wilkinson (1983) Tbomas L. Gavan (1983) Arvind A. Padhye (1981) Robert P. Williams (1981) Gerald L. Gillardi (1983) Demosthenes Pappagianis (1983) Marion E. Wilson (1983) Robert C. Good (1982) William A. Pascule (1983) Kwei-Hay Wong (1983) Norman L. Goodman (1983) Jerold Penn (1983) G. N. Woode (1982) Morris A. Gordon (1981) M. John Pickett (1982) Robert H. Yolken (1981) Richard Polin (1983) Gisella PoUock, Acting Managing Editor Paula R. Gerhardt, Production Editor 1913 I St., NW, Washington, DC 20006 EX OFFICIO Mbert Balows, President (1980-1981) Frederick C. Neidhardt, President-Elect (1980-1981) J. Mehsen Joseph, Secretary Brinton M. Miller, Treasurer

The Journal of Clinical Microbiology (ISSN 0095-1137), a a * : idé el i-t y.ik A'É' L i-t mfli la: < 1 1 1kt. publication ofthe American Society for Microbiology, 1913 I St., NW, Washington, DC 20006, is devoted to the dissemination of new knowledge concerning the applied microbiological aspects Second-class postage paid at Washington, DC 20006. and at of human and animal infections and infestations, particularly additional mailing offices. regarding their etiologic agents, diagnosis. and epidemiology. Made in the United States of America. Papers dealing with antibiotics and antimicrobial agents and Copyright © 1981, American Society for Microbiology. chemotherapy, with fundamental aspects of infection and im- All Rights Reserved. munity, and with food or dairy microbiology fall within the scope ofother ASM publications. Instructions to Authors are published The code at the top of the first page of an article in this journal in the January issue each year; reprints are available from the indicates the copyright owner's consent that copies of the article Editors and the Publications Office. The Journal is published may be made for personal use, or for personal use of specific monthly, and the twelve numbers are divided into two volumes clients. This consent is given on the condition, however, that the per year. The nonmember subscription price is $80 per year. The copier pay the stated per-copy fee through the Copyright Clear- member subscription price is $22 per year. Single copies are $8. ance Center, Inc., P.O. Box 765, Schenectady, New York 12301, Correspondence relating to subscriptions, reprints, defective cop- for copying beyond that permitted by Sections 107 and 108 of ies, availability of back issues, lost or late proofs, disposition of the U.S. Copyright Law. This consent does not extend to other submitted manuscripts, and general editorial matters should be kinds of copying. such as copying for general distribution, for directed to the ASM Publications Office, 1913 I St., NW. Wash- advertising or promotional purposes, for creating new collective ington, DC 20006 (area 202 833-9680). works, or for resale. Author Index

Abbey, Lawrence E., 313 Halonen, P. E., 258 Oblack, Donna L., 351 Actor, Paul, 301 Han, Dennis P., 293 Olsson, Eva, 252 Allen, C. I., 388 Hanna, Bruce A., 320 Orskov, Fritz, 252 Arstila, P. P., 258 Harada, William A., 279 0rskov, Ida, 252 Hierholzer, John C., 395 Babb, James L., 369 Highsmith, Anita K., 313 Patton, Charlotte M., 326 Bailey, Raymond E., 344 Hill, William B., 383 Pereira, Artur T., 245 Bannister, Edward R., 331 Hitchings, Maryl M., 309 Pollice, Marjorie, 335 Barksdale, Lane, 335 Holmes, Ian H., 272 Potter, Morris E., 326 Bartus, Henry F., 301 Holmes, Rustin L., 279 Prendergast, Edward, 390 Bennett, John E., 383 Proctor, Richard A., 390 Birch, Chris, 272 Inouye, Sakae, 248 Bishop, Ruth F., 272 Reiner, Eugene J., 313 Bobey, David G., 393 Jackson, Francis L., 286 Rhcdes, Judith C., 351 Brown, Arnold, 380 Jacobson, Richard H., 309 Rodger, Suzanne M., 272 Brown, Susan L., 398 Rodriguez, Fred H., Jr., 395 Burdash, Nicholas M., 331 Jones, Wallis L., 398 Salmi, A. A., 258 Kaufmann, Arnold F., 326 Calisher, Charles H., 344 Sanders, Judith L., 293 Kingsley, Lance C., 283 Sarkkinen, H. K., 258 Cummins, C. S., 369 Klein, George C., 398 Cypess, Raymond H., 309 Sedlock, David M., 301 Kono, Reisaku, 248 Sheagren, John N., 293 Kwon-Chung, Kyung J., 383 Sheagren, Martha A., 293 D'Alessio, D. J., 388 Smyth, Cyril J., 252 Davis, John W., 320 Linder, Regina, 335 Soderlind, Olof, 252 Duncan, Rory A., 283 Luechtefeld, Nancy W., 266 Sulea, Ioan T., 335

Ederer, Grace M., 393 Manos, John P., 331 Taylor, Roger N., 356 Martin, William J., 351 Teti, Giuseppe, 331 Frank, Sandra K., 269 McKinney, Frederick T., 398 Tsiatis, A. A., 388 Fulford, Karen M., 356 McLean, Barbara, 272 Menes, Bambi L., 293 Vickers, Richard M., 380 Garrity, George M., 380 Minor, T. E., 388 Gerber, Jay D., 269 Mitchell, Sheila W., 326 Wang, Wen-Lan Lou, 266 Gittelman, Howard J., 309 Moncalvo, Cristina, 252 West, Marcia E., 331 Goodman, Yvonne E., 286 Moran, Thomas F., 313 Wort, Arthur J., 286 Gordon, Morris A., 283 Grieve, Robert B., 309 Nelson, D. B., 388 Zajac, Ihor, 301 verlag chemie MANUAL DAHLEM WORKSHOP REPORTS-LIFE SCIENCES RESEARCH REPORTS. 0F Vol. 21, NEURONAL-GLIAL CELL INTERRELATIONSHIPS: ONTOGENY, CLINICAL MAINTENANCE, INJURY, REPAIR. In preparation. Vol. 16, THE MOLECULAR BASIS OF IMMUNOLOGY MICROBIAL PATHOGENICITY. H. Smith, 2nd Edition J. J. Skehel, M. J. Turner. 1980. 357 pages. $27.50 paper Edited by Vol. 15, BIOMEDICAL PATTERN Noel R. Rose and Herman Friedman RECOGNITION AND IMAGE PROCESSING. K. S. Fu, T. Pavlidis. 1979. 443 pages. $33.80 paper 1,105 pages, fully illustrated Vol. 14, THE ROLE OF INTERCELLULAR SIGNALS: NAVIGATION, ENCOUNTER, Clothbound: S25.00 OUTCOME. J. G. Nicholls. 1979. 309 pages. (S18.00 to ASM Members) $27.50 paper Flexible binding: S21.00 Vol. 13, STRATEGIES OF MICROBIAL LIFE IN EXTREME ENVIRONMENTS. M. Shilo. (S15.00 to ASM Members) 1979. 514 pages. $42.40 paper Published and distributed by: We will gladly send you further information American Soclety for Mlcrobiology on any of the Dahlem titles. 19131 Street, NW verlag chemie international, inc. Washington, DC 20006 1020 N.W. 6th Street, Deerfield Beach, FL 33441 Tel: (305) 428-5566 I merican Society for Microbiology

ANNOUNCING THIRD INTERNATIONAL SYMPOSIUM ON RAPID METHODS AND AUTOMATION IN MICROBIOLOGY* 26-30 WASHINGTON, D.C. TOPICAL AREAS WILL INCLUDE * clinical, medical, and public health microbiology * industrial microbiology * environmental microbiology * food microbiology * quality control * microbiological technology in developing nations For further information write: Dr. Richard C. Tilton, Chairman ISRMA Planning Committee University of Connecticut Health Center Department of Laboratory Medicine 263 Farmington Avenue Farmington, Connecticut 06032 * Sponsored by the American Society for Microbiology uvouecuuar-Announcing a new journal from ASM and Cellular Biology Editor-in-Chief: Editors: Aaron J. Shatkin Paul S. Sypherd, Louis Siminovitch, Keith R. Porter - Molecular and Cellular Biology m First issue: . Monthly. is devoted to the advancement and About 1,200 pages a year. Please dissemination of fundamental knowl- submit manuscripts to the ASM edge concerning eucaryotic cells of Publications Office. Members who wish both microbial and higher organisms. to subscribe, at $16.00 a year, should Papers on cellular morphology and select MCB when they receive the Dues function, genome organization and the Bill. Non-members of the Society regulation of genetic expression, should send their order and remittance morphogenesis, physiology and muta- of $50.00 for 12 issues to: M. Poe, tion, and somatic cell genetics are American Society for Microbiology, invited for submission. PO Box 1192, Birmingham, AL 35201. Published by: American Society for Microbiology 1913 1 Street, NW Washington, DC 20006 &mericanSociety for Microbiology INDEX TO ADVERTISERS Page

American Scientific Products ...... 6, 7

* Analytab Products ...... Cover 2 Argus, Inc...... Cover 3 * Becton-Dickinson...... 19 Cathra International...... Cover 3 * Clinical Sciences, Inc...... Cover 4 * Difco Laboratories ...... 26 Gibco/Invenex ...... 16 * Hynson Westcott ...... il * Marion Scientific Corp...... 12, 13, 17 Meridian Diagnostics. ...8 Micro-Media Systems. ...15 Pharmacia Diagnostics. ...14 Verlag Chemie International ...... 10 * Vitek Systems Inc...... 9 * Sustaining Member, American Society for Microbiology.

Advertising in this journal is limited to products and services believed to be of interest to the readers. However, ASM does not test nor examine advertised products nor claims related thereto. Therefore, ASM endorsement or approval of advertised products should not be inferred.