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Appendix 1 Chemico-Biological Interactions 301 (2019) 2–5 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint An examination of the linear no-threshold hypothesis of cancer risk T assessment: Introduction to a series of reviews documenting the lack of biological plausibility of LNT R. Goldena,*, J. Busb, E. Calabresec a ToxLogic, Gaithersburg, MD, USA b Exponent, Midland, MI, USA c University of Massachusetts, Amherst, MA, USA The linear no-threshold (LNT) single-hit dose response model for evolution and the prominence of co-author Gilbert Lewis, who would be mutagenicity and carcinogenicity has dominated the field of regulatory nominated for the Nobel Prize some 42 times, this idea generated much risk assessment of carcinogenic agents since 1956 for radiation [8] and heat but little light. This hypothesis was soon found to be unable to 1977 for chemicals [11]. The fundamental biological assumptions upon account for spontaneous mutation rates, underestimating such events which the LNT model relied at its early adoption at best reflected a by a factor of greater than 1000-fold [19]. primitive understanding of key biological processes controlling muta- Despite this rather inauspicious start for the LNT model, Muller tion and development of cancer. However, breakthrough advancements would rescue it from obscurity, giving it vast public health and medical contributed by modern molecular biology over the last several decades implications, even proclaiming it a scientific principle by calling it the have provided experimental tools and evidence challenging the LNT Proportionality Rule [20]. While initially conceived as a driving force model for use in risk assessment of radiation or chemicals. -
Moore Noller
2002 Ada Doisy Lectures Ada Doisy Lecturers 2003 in BIOCHEMISTRY Sponsored by the Department of Biochemistry • University of Illinois at Urbana-Champaign Dr. Peter B. 1970-71 Charles Huggins* and Elwood V. Jensen A76 1972-73 Paul Berg* and Walter Gilbert* Moore 1973-74 Saul Roseman and Bruce Ames Department of Molecular carbonyl Biophysics & Biochemistry Phe 1974-75 Arthur Kornberg* and Osamu Hayaishi Yale University C75 1976-77 Luis F. Leloir* New Haven, Connecticutt 1977-78 Albert L. Lehninger and Efraim Racker 2' OH attacking 1978-79 Donald D. Brown and Herbert Boyer amino N3 Tyr 1979-80 Charles Yanofsky A76 4:00 p.m. A2486 1980-81 Leroy E. Hood Thursday, May 1, 2003 (2491) 1983-84 Joseph L. Goldstein* and Michael S. Brown* Medical Sciences Auditorium 1984-85 Joan Steitz and Phillip Sharp* Structure and Function in 1985-86 Stephen J. Benkovic and Jeremy R. Knowles the Large Ribosomal Subunit 1986-87 Tom Maniatis and Mark Ptashne 1988-89 J. Michael Bishop* and Harold E. Varmus* 1989-90 Kurt Wüthrich Dr. Harry F. 1990-91 Edmond H. Fischer* and Edwin G. Krebs* 1993-94 Bert W. O’Malley Noller 1994-95 Earl W. Davie and John W. Suttie Director, Center for Molecular Biology of RNA 1995-96 Richard J. Roberts* University of California, Santa Cruz 1996-97 Ronald M. Evans Santa Cruz, California 1998-99 Elizabeth H. Blackburn 1999-2000 Carl R. Woese and Norman R. Pace 2000-01 Willem P. C. Stemmer and Ronald W. Davis 2001-02 Janos K. Lanyi and Sir John E. Walker* 12:00 noon 2002-03 Peter B. -
MCDB 5220 Methods and Logics April 21 2015 Marcelo Bassalo
Cracking the Genetic Code MCDB 5220 Methods and Logics April 21 2015 Marcelo Bassalo The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) Frederick Griffith The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) Oswald Avery Alfred Hershey Martha Chase The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) • X-ray diffraction and the structure of proteins (1951) Linus Carl Pauling The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) • X-ray diffraction and the structure of proteins (1951) • The structure of DNA (1953) James Watson and Francis Crick The DNA Saga… so far Important contributions for cracking the genetic code: • The “transforming principle” (1928) • The nature of the transforming principle: DNA (1944 - 1952) • X-ray diffraction and the structure of proteins (1951) • The structure of DNA (1953) How is DNA (4 nucleotides) the genetic material while proteins (20 amino acids) are the building blocks? ? DNA Protein ? The Coding Craze ? DNA Protein What was already known? • DNA resides inside the nucleus - DNA is not the carrier • Protein synthesis occur in the cytoplasm through ribosomes {• Only RNA is associated with ribosomes (no DNA) - rRNA is not the carrier { • Ribosomal RNA (rRNA) was a homogeneous population The “messenger RNA” hypothesis François Jacob Jacques Monod The Coding Craze ? DNA RNA Protein RNA Tie Club Table from Wikipedia The Coding Craze Who won the race Marshall Nirenberg J. -
A Cultural Analysis of a Physicist ''Trio'' Supporting the Backlash Against
ARTICLE IN PRESS Global Environmental Change 18 (2008) 204–219 www.elsevier.com/locate/gloenvcha Experiences of modernity in the greenhouse: A cultural analysis of a physicist ‘‘trio’’ supporting the backlash against global warming Myanna Lahsenà Center for Science and Technology Policy Research, University of Colorado and Instituto Nacional de Pesquisas Epaciais (INPE), Av. dos Astronautas, 1758, Sa˜o Jose´ dos Campos, SP 12227-010 Brazil Received 18 March 2007; received in revised form 5 October 2007; accepted 29 October 2007 Abstract This paper identifies cultural and historical dimensions that structure US climate science politics. It explores why a key subset of scientists—the physicist founders and leaders of the influential George C. Marshall Institute—chose to lend their scientific authority to this movement which continues to powerfully shape US climate policy. The paper suggests that these physicists joined the environmental backlash to stem changing tides in science and society, and to defend their preferred understandings of science, modernity, and of themselves as a physicist elite—understandings challenged by on-going transformations encapsulated by the widespread concern about human-induced climate change. r 2007 Elsevier Ltd. All rights reserved. Keywords: Anti-environmental movement; Human dimensions research; Climate change; Controversy; United States; George C. Marshall Institute 1. Introduction change itself, what he termed a ‘‘strong theory of culture.’’ Arguing that the essential role of science in our present age Human Dimensions Research in the area of global only can be fully understood through examination of environmental change tends to integrate a limited con- individuals’ relationships with each other and with ‘‘mean- ceptualization of culture. -
Cornell Alumni Magazine
c1-c4CAMja11 6/16/11 1:25 PM Page c1 July | August 2011 $6.00 Alumni Magazine Well-Spoken Screenwriter (and former stutterer) David Seidler ’59 wins an Oscar for The King’s Speech cornellalumnimagazine.com c1-c4CAMja11 6/16/11 1:25 PM Page c2 01-01CAMja11toc 6/20/11 1:19 PM Page 1 July / August 2011 Volume 114 Number 1 In This Issue Alumni Magazine 34 Corne 2 From David Skorton Farewell, Mr. Vanneman 4 The Big Picture Card sharp 6 Correspondence DVM debate 8 Letter from Ithaca Justice league 10 From the Hill Capped and gowned 14 Sports Top teams, too 16 Authors Eyewitness 32 Wines of the Finger Lakes Ports of New York “Meleau” White 18 10 52 Classifieds & 34 Urban Cowboys Cornellians in Business 53 Alma Matters BRAD HERZOG ’90 56 Class Notes Last October, the Texas Rangers won baseball’s American League pennant—and played in their first-ever World Series. Two of the primary architects of that long-sought vic- 91 Alumni Deaths tory were Big Red alums from (of all places) the Big Apple. General manager Jon 96 Cornelliana Daniels ’99 and senior director of player personnel A. J. Preller ’99 are old friends and Little house in the big woods lifelong baseball nuts who brought fresh energy to an underperforming franchise. And while they didn’t take home the championship trophy . there’s always next season. Legacies To see the Legacies listing for under- graduates who entered the University in fall 40 Training Day 2010, go to cornellalumnimagazine.com. JIM AXELROD ’85 Currents CBS News reporter Jim Axelrod has covered everything from wars to presidential cam- paigns to White House politics. -
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C
15/5/40 Liberal Arts and Sciences Chemistry Irwin C. Gunsalus Papers, 1877-1993 BIOGRAPHICAL NOTE Irwin C. Gunsalus 1912 Born in South Dakota, son of Irwin Clyde and Anna Shea Gunsalus 1935 B.S. in Bacteriology, Cornell University 1937 M.S. in Bacteriology, Cornell University 1940 Ph.D. in Bacteriology, Cornell University 1940-44 Assistant Professor of Bacteriology, Cornell University 1944-46 Associate Professor of Bacteriology, Cornell University 1946-47 Professor of Bacteriology, Cornell University 1947-50 Professor of Bacteriology, Indiana University 1949 John Simon Guggenheim Fellow 1950-55 Professor of Microbiology, University of Illinois 1955-82 Professor of Biochemistry, University of Illinois 1955-66 Head of Division of Biochemistry, University of Illinois 1959 John Simon Guggenheim Fellow 1959-60 Research sabbatical, Institut Edmund de Rothchild, Paris 1962 Patent granted for lipoic acid 1965- Member of National Academy of Sciences 1968 John Simon Guggenheim Fellow 1972-76 Member Levis Faculty Center Board of Directors 1977-78 Research sabbatical, Institut Edmund de Rothchild, Paris 1973-75 President of Levis Faculty Center Board of Directors 1978-81 Chairman of National Academy of Sciences, Section of Biochemistry 1982- Professor of Biochemistry, Emeritus, University of Illinois 1984 Honorary Doctorate, Indiana University 15/5/40 2 Box Contents List Box Contents Box Number Biographical and Personal Biographical Materials, 1967-1995 1 Personal Finances, 1961-65 1-2 Publications, Studies and Reports Journals and Reports, 1955-68 -
Mechanisms of Microbial Genetics 443
Chapter 11 | Mechanisms of Microbial Genetics 443 Chapter 11 Mechanisms of Microbial Genetics Figure 11.1 Escherichia coli (left) may not appear to have much in common with an elephant (right), but the genetic blueprints for these vastly different organisms are both encoded in DNA. (credit left: modification of work by NIAID; credit right: modification of work by Tom Lubbock) Chapter Outline 11.1 The Functions of Genetic Material 11.2 DNA Replication 11.3 RNA Transcription 11.4 Protein Synthesis (Translation) 11.5 Mutations 11.6 How Asexual Prokaryotes Achieve Genetic Diversity 11.7 Gene Regulation: Operon Theory Introduction In 1954, French scientist and future Nobel laureate Jacques Monod (1910–1976) famously said, “What is true in E. coli is true in the elephant,” suggesting that the biochemistry of life was maintained throughout evolution and is shared in all forms of known life. Since Monod’s famous statement, we have learned a great deal about the mechanisms of gene regulation, expression, and replication in living cells. All cells use DNA for information storage, share the same genetic code, and use similar mechanisms to replicate and express it. Although many aspects of genetics are universally shared, variations do exist among contemporary genetic systems. We now know that within the shared overall theme of the genetic mechanism, there are significant differences among the three domains of life: Eukarya, Archaea, and Bacteria. Additionally, viruses, cellular parasites but not themselves living cells, show dramatic variation in their genetic material and the replication and gene expression processes. Some of these differences have allowed us to engineer clinical tools such as antibiotics and antiviral drugs that specifically inhibit the reproduction of pathogens yet are harmless to their hosts. -
New Ways of Thinking About Telomeres and Telomerase
AA98 99 D 1998-99 Ada Doisy Lecture in Biochemistry Ada Doisy Lecturers New Ways of Thinking 1970-71 Charles Huggins* and Elwood V. Jensen About Telomeres and Telomerase 1972-73 Paul Berg* and Walter Gilbert* 1973-74 Saul Roseman and Bruce Ames 1974-75 Arthur Kornberg* and Osamu Hayaishi 1976-77 Luis F. Leloir* 1977-78 Albert L. Lehninger and Efraim Racker 1978-79 Donald D. Brown and Herbert Boyer 1979-80 Charles Yanofsky 1980-81 Leroy E. Hood 1983-84 Joseph L. Goldstein* and Michael S. Brown* 1984-85 Joan Steitz and Phillip Sharp* 1985-86 Stephen J. Benkovic and Jeremy R. Knowles 1986-87 Tom Maniatis and Mark Ptashne 1988-89 J. Michael Bishop* and Harold E. Varmus* 1989-90 Kurt Wüthrich 1990-91 Edmond H. Fischer* and Edwin G. Krebs* 1993-94 Bert W. O’Malley 1994-95 Earl W. Davie and John W. Suttie 1995-96 Richard J. Roberts* 1996-97 Ronald M. Evans Dr. Elizabeth H. Blackburn 1998-99 Elizabeth H. Blackburn Professor and Chair Department of Microbiology and Immunology University of California, San Francisco *Indicates received Nobel Laureate 12:00 noon Friday, September 11, 1998 Medical Sciences Auditorium In 1970, Dr. Edward A. Doisy endowed the Ada Doisy Lectures in Biochemistry in honor of his mother. Dr. Doisy described his mother as “a kind and gentle woman who was always racing her motor in a determined and well-governed direction toward her objective.” Dr. Doisy noted that she was devout in her Baptist beliefs and that “the other god she also worshipped seven days a week was knowledge and education, and she early inculcated this adoration into her New Ways of Thinking About children.” He also noted that she was best remembered for Telomeres and Telomerase “an inflexible tenacity of purpose, of “stick-to-it-iveness,” and of wrestling with and solving problems against all obstacles.” Dr. -
OLC Denies FOIA Request for Opinion on Executive Orders
FEDERATION OF AMERICAN SCIENTISTS Board of Sponsors 1725 DeSales Street NW, 6th floor [email protected] (Partial List) Washington, DC 20036 www.fas.org *Sidney Altman Phone: (202) 546-3300 Fax: (202) 675-1010 Bruce Ames F.A.S. *Philip W. Anderson *Kenneth J. Arrow *Julius Axelrod *David Baltimore Frank von Hippel Hal Feiveson Henry C. Kelly Paul Beeson Chairman Secretary-Treasurer President *Baruj Benacerraf *Hans A. Bethe *J. Michael Bishop *Nicolaas Bloembergen *Norman Borlaug *Paul Boyer March 11, 2008 *Owen Chamberlain (202)454-4691 Morris Cohen *Stanley Cohen [email protected] Mildred Cohn *Leon N. Cooper Elizabeth Farris *E. .J. Corey Paul B. Cornely Office of Legal Counsel *James Cronin *Johann Deisenhofer Room 5515, 950 Pennsylvania Avenue, NW Carl Djerassi Ann Druyan Department of Justice *Renato Dulbecco John T. Edsall Washington, DC 20530-0001 Paul R. Ehrlich By fax: 202-514-0563 George Field *Val L. Fitch Jerome D. Frank *Jerome I. Friedman Dear Ms. Farris: *John Kenneth Galbraith *Walter Gilbert *Donald Glaser *Sheldon L. Glashow This is a request under the Freedom of Information Act. Marvin L. Goldberger *Joseph L. Goldstein *Roger C. L. Guillemin We request a copy of an Office of Legal Counsel opinion from the George *Dudley R. Herschbach *Roald Hoffmann W. Bush Administration pertaining in part to the efficacy of executive John P. Holdren *David H. Hubel orders. *Jerome Karle Nathan Keyfitz *H. Gobind Khorana *Arthur Kornberg In particular, Senator Sheldon Whitehouse stated on the Senate floor on *Edwin G. Krebs *Willis E. Lamb December 7 that he had examined an OLC opinion which included, *Leon Lederman *Edward Lewis according to his notes, the following statement or something resembling it: *William N. -
Dnai DVD and the Dnai Teacher Guide Dnai
DNAi DVD 1 DNAi DVD and the DNAi Teacher Guide The DNA Interactive (DNAi) DVD carries approximately four hours of video interviews with 11 Nobel Laureates and more than 50 other scientists, clinicians, and patients. It also holds the complete set of 3-dimensional animations produced for the DNA TV series and DNAi project. The following pages list video clips and animations from the DVD that would be appropriate to show with specific activities in the DNAi Teacher Guide. The clips and animations are listed under “themes” and “additional animations.” The “themes” listing includes relevant interviews and animations that can be accessed from the “themes” section of the DVD. The “additional animations” are best accessed from “animations” button in the DVD main menu. You can access the DNAi Teacher Guide by registering at www.dnai.org/teacher. Activity 1: DNAi Timeline: a scavenger hunt THEMES • DNA MOLECULE • Discovery of DNA A pre-1953 notion _ biology prior to discovery of the double helix . François Jacob DNA is the genetic material _ the experiment that identified DNA as the genetic material . Maclyn McCarty Chargaff's ratios _ the DNA base ratio rules . Erwin Chargaff The answer _ the X-ray diffraction picture that revealed the helix . Maurice Wilkins DNA: the key to understanding _ why the discovery of DNA's structure was so important . Francis Crick Structure of DNA The correct model _ Meselson and Franklin Stahl's experiment to determine the correct DNA replication mode . Matthew Meselson • DNA IN ACTION • The genetic code Defining the gene _ matching the gene to protein sequence . -
Iasthe Institute Letter
G13-16400_IL_FALL2013_Layout 1 12/19/13 10:06 AM Page 1 The Institute Letter InsItitute foAr Advanced SStudy Fall Economics: Science, Craft, or Snake Oil? Ellsworth Kelly’s Dream of Impersonality When economists skip over real-world complications, it’s as if How things that look apparently very simple are in fact much physicists spoke of a world without gravity. more complex than they seem BY DANI RODRIK BY YVE-ALAIN BOIS hen the 2013 Sveriges Riksbank llsworth Kelly is one of the very first WPrize in Economic Sciences in Eartists whose work I liked. Perhaps Memory of Alfred Nobel (colloquially he was second, just after Piet Mondrian. known as the “Economics Nobel”) was One of the things I asked Kelly after we awarded to Eugene Fama and Robert finally met and became friends, close to Shiller, along with Lars Peter Hansen, a quarter of a century ago, was why he N O I many were puzzled by the selection. had not answered a fan letter that I had T C E L L Fama and Shiller are both distinguished written to him in my teens. He remem- O C Y R L E and highly regarded scholars, so it was bered the letter. He had received it at a L K E R K O H Y not their qualifications that raised eye- time when he felt isolated, bypassed by a T R W E O N brows. What seemed odd was that the new generation of artists, and he had W E S L H L T / E R committee had picked them together. -
Statement of William Happer at the Public Hearing of the Bundestag, 21 July, 2021
Statement of William Happer at the public hearing of the Bundestag, 21 July, 2021. Ausschuss für Umwelt, Naturschutz und nukleare Sicherheit I am Dr. William Happer a Professor of Physics, Emeritus at Princeton University, located in the state of New Jersey of the United States of America. Let me suggest why my comments today should be taken seriously. I have published over 200 peer-reviewed scientific papers, many of them on the interaction of radiation with matter, the basic physics that determines how greenhouse gases influence Earth’s climate. I am the inventor of the sodium guide star, which is used in most new ground-based telescopes to measure and correct for the degradation of astronomical images by atmospheric turbulence. I served as the Director of the Office of Energy Research of the US Department of Energy from 1990 to 1993, where I supervised a research budget of some $3.5 billion. A sizable part of this was directed toward environmental and climate science. From 2018 to 2019, I served as the Deputy Assistant to the President and Senior Director for Emerging Technologies at the National Security Council in the White House. I have received a number of scientific awards, and I am a member of several scientific societies, including the American Physical Society, the US National Academy of Sciences and the Philosophical Society. With this background, I know more than most scientists about how greenhouse gases work. Increasing levels of the main anthropogenic greenhouse gas, carbon dioxide (CO2), will cause a small, beneficial warming of Earth’s climate. More CO2 will be very good for agriculture, forestry, and all photosynthetic life.