100 Heterosigma akashiwo CCMP 452 81 Chattonella subsalsa CCMP2191 GTR Ectocarpus siliculosus Ochromonas sp. CCMP1393 Nannochloropsis gaditana 80 Kryptoperidinium foliaceum CCMP 1326 stramenopiles Durinskia baltica CSIRO CS-38 Thalassiosira pseudonana 0.2 100 Phaeodactylum tricornutum 52 Odontella aurita isolate 1302-5 Aureococcus anophagefferens CCMP1850 0.4 79 Lepidodinium chlorophorum NIES-1868 71 catenatum GC744 Togula jolla CCCM 725 Lingulodinium polyedrum CCMP 1738 100 micrum CCMP2283 brevis CCMP2229 sp. CCMP421 72 carterae CCMP1314 Heterocapsa rotundata SCCAP K-0483 100 aciculiferum PAER-2 56 Durinskia baltica CSIRO CS-38 38 63 Kryptoperidinium foliaceum CCMP 1326 Kryptoperidinium foliaceum CCMP 1326 100 Lepidodinium chlorophorum NIES-1868 Lepidodinium chlorophorum NIES-1868 99 Prymnesium parvum_Texoma1 67 Chrysochromulina polylepis UIO037 Coccolithus pelagicus ssp braarudi PLY182g 68 100 68 100 56 oceanica RCC1303 Isochrysis galbana CCMP 1323 66 71 CCMP2229 Karlodinium micrum CCMP2283 Pavlova sp. CCMP459 97 Chlorarachnion reptans CCCM449 51 Bigelowiella natans CCMP1258.1 100 Gymnochlora sp. CCMP2014 chlorarachniophytes Lotharella globosa LEX01 Rhodella maculata CCMP 736 red alga 59 Rhodomonas salina CCMP1319 80 70 Guillardia theta Cryptomonas curvata CCAP979/52 100 Hemiselmis andersenii CCMP441 cryptophytes 73 Cryptomonas curvata CCAP979/52 Rhodosorus marinus UTEX LB 2760 Galdieria sulphuraria Chondrus crispus 52 63 red Porphyridium aerugineum SAG 1380-2 Cyanidioschyzon merolae 100 Chlamydomonas reinhardtii 95 Volvox carteri f. nagariensis 82 Eutreptiella gymnastica NIES-381 euglenid 100 Ostreococcus tauri 100 Micromonas sp. RCC299 89 Arabidopsis thaliana 96 green plants 100 Oryza sativa japonica Physcomitrella patens subsp. patens 100 Nostoc sp. PCC 7120 Anabaena variabilis Acaryochloris marina 100 Synechocystis sp. PCC 6803 Microcystis aeruginosa 65 Trichodesmium erythraeum cyanobacteria 79 Thermosynechococcus elongatus 100 cyanelle in Paulinella chromatophora Synechococcus sp. WH8102 100 Burkholderia xenovorans LB400 98 Ralstonia solanacearum GMI1000 Neisseria meningitidis Z2491 100 100 Escherichia coli K-12 MG1655 100 Vibrio cholerae O395 58 Pseudoalteromonas atlantica 83 Staphylococcus aureus subsp. aureus ED98 bacteria 67 100 Bacillus anthracis_Ames Listeria monocytogenes EGD-e 51 Corynebacterium diphtheriae NCTC 13129 100 Mycobacterium tuberculosis H37Rv Streptomyces coelicolor 100 Thermoplasma volcanium 100 Picrophilus torridus 59 Pyrobaculum aerophilum archaea Sulfolobus tokodaii 83 Hemiselmis andersenii CCMP441 56 Rhodomonas salina CCMP1319 70 GSAT Cryptomonas CCAP977/2a cryptophytes 96 Guillardia theta Aureococcus anophagefferens CCMP1850 stramenopile 87 Durinskia baltica CSIRO CS-38 62 Ochromonas sp. CCMP1393 0.1 99 Chattonella subsalsa CCMP2191 stramenopiles Heterosigma akashiwo CCMP 452 Eutreptiella gymnastica NIES-381 euglenid 0.3 Karlodinium micrum CCMP2283 Lepidodinium chlorophorum NIES-1868 Gymnodinium catenatum GC744 Togula jolla CCCM 725 Peridinium aciculiferum PAER-2 84 Lingulodinium polyedrum CCMP 1738 Alexandrium catenella OF101 98 Durinskia baltica CSIRO CS-38 dinoflagellates Kryptoperidinium foliaceum CCMP 1326 70 Lepidodinium chlorophorum NIES-1868 Karenia brevis CCMP2229 Heterocapsa rotundata SCCAP K-0483 Symbiodinium sp. CCMP421 CCMP1314 Odontella aurita isolate 1302-5 51 Kryptoperidinium foliaceum CCMP 1326 78 Thalassiosira pseudonana 100 Durinskia baltica CSIRO CS-38 stramenopiles Phaeodactylum tricornutum 79 Gymnochlora sp. CCMP2014 56 Lotharella globosa LEX01 100 Chlorarachnion reptans CCCM449 chlorarachniophytes Bigelowiella natans CCMP1258.1 99 RCC1303 60 Emiliania huxleyi 95 Isochrysis galbana CCMP1323

100 Coccolithus pelagicus ssp braarudi PLY182g haptophytes Prymnesium parvum_Texoma1 Chrysochromulina polylepis UIO037 Pavlova sp. CCMP459 100 Chlamydomonas reinhardtii 78 Volvox carteri f. nagariensis 89 87 Chlorella variabilis green plants 100 Ostreococcus tauri Micromonas sp. RCC299 96 Rhodosorus marinus UTEX LB 2760 66 Porphyridium aerugineum SAG 1380-2 red algae Rhodella maculata CCMP736 100 Nostoc sp. PCC 7120 54 Anabaena variabilis 62 Acaryochloris marina 89 Trichodesmium erythraeum 91 Synechocystis sp. PCC 6803 58 cyanobacteria Microcystis aeruginosa 100 100 Prochlorococcus marinus SS120 Synechococcus sp. WH8102 Gloeochaete witrockiana SAG 46.84 glaucophyte 94 Arabidopsis thaliana Oryza sativa japonica green plants Cyanidioschyzon merolae red alga 100 Listeria monocytogenes EGD-e Staphylococcus aureus subsp. aureus ED98 63 Streptomyces coelicolor 100 Mycobacterium tuberculosis H37Rv 71 Corynebacterium diphtheriae NCTC 13129 Lepidodinium chlorophorum NIES-1868 100 Picrophilus torridus bacteria 100 Thermoplasma volcanium

85 100 Pyrobaculum aerophilum archaea Sulfolobus tokodaii 100 Listeria monocytogenes EGD-e Staphylococcus aureus subsp. aureus ED98 100 Emiliania huxleyi 97 Emiliania huxleyi PLY M219 96 Isochrysis galbana CCMP1323 83 Coccolithus pelagicus ssp braarudi PLY182g 96 100 Prymnesium parvum_Texoma1 haptophytes Chrysochromulina polylepis UIO037 57 Pavlova sp. CCMP459 88 Heterosigma akashiwo CCMP 452 Chattonella subsalsa CCMP2191 stramenopiles 73 CCMP2878 50 CCMP3155 chromerids 92 Durinskia baltica CSIRO CS-38 ALAD Ochromonas sp. CCMP1393 53 Thalassiosira pseudonana Phaeodactylum tricornutum 91 Odontella aurita isolate 1302-5 98 Durinskia baltica CSIRO CS-38 stramenopiles Kryptoperidinium foliaceum CCMP 1326 Aureococcus anophagefferens CCMP1850 96 Bigelowiella natans CCMP1258.1 91 Chlorarachnion reptans CCCM449 99 0.2 Gymnochlora sp. CCMP2014 chlorarachniophytes Lotharella globosa LEX01 apicomplexan parasite Cryptomonas curvata CCAP979/52 0.4 74 Rhodomonas salina CCMP1319 70 100 Guillardia theta cryptophytes Hemiselmis andersenii CCMP441 Porphyridium aerugineum SAG 1380-2 red alga 60 Chlorarachnion reptans CCCM449 50 Gymnochlora sp. CCMP2014 chlorarachnio- 100 Bigelowiella natans CCMP1258.1 Lotharella globosa LEX01 phytes 76 Galdieria sulphuraria 86 Cyanidioschyzon merolae Rhodella maculata CCMP 736 Rhodosorus marinus UTEX LB 2760 red algae Chondrus crispus Togula jolla CCCM 725 Lepidodinium chlorophorum NIES-1868 Heterocapsa rotundata SCCAP K-0483 Amphidinium carterae CCMP1314 55 Karlodinium micrum CCMP2283 Karenia brevis CCMP2229 Symbiodinium sp. CCMP421 dinoflagellates Lingulodinium polyedrum CCMP 1738 93 Durinskia baltica CSIRO CS-38 99 Kryptoperidinium foliaceum CCMP 1326 Alexandrium catenella OF101 Peridinium aciculiferum PAER-2 94 100 Chlamydomonas reinhardtii 72 60 Volvox carteri f. nagariensis 98 Chlorella variabilis 52 100 Ostreococcus tauri Micromonas sp. RCC299 Oryza sativa japonica green plants 100 Arabidopsis thaliana 67 Arabidopsis thaliana 53 Eutreptiella gymnastica NIES-381 euglenid Gloeochaete witrockiana SAG 46.84 glaucophyte 98 Prochlorococcus marinus SS120 100 Synechococcus sp. WH8102 cyanell in Paulinella chromatophora cyanobacteria 34 Acanthamoeba castellanii heterotrophic 100 Nostoc sp. PCC 7120 Anabaena variabilis Microcystis aeruginosa Trichodesmium erythraeum 70 Anabaena variabilis cyanobacteria 40 Thermosynechococcus elongatus 100 Acaryochloris marina Lepidodinium chlorophorum NIES-1868 99 Burkholderia xenovorans LB400 33 Ralstonia solanacearum GMI1000 75 Neisseria meningitidis Z2491 100 Vibrio cholerae O395 Pseudoalteromonas atlantica 98 100 Nitrobacter hamburgensis 48 27 Rhodopseudomonas palustris CGA009 bacteria 50 Rickettsia prowazekii_Madrid E 21 Sphingomonas sp. MM-1 Rhodospirillum centenum 67 Microcystis aeruginosa 51 Synechocystis sp. PCC 6803 52 100 Nostoc sp. PCC 7120 Anabaena variabilis cyanobacteria 97 Acaryochloris marina Bacillus anthracis_Ames 100 Listeria monocytogenes EGD-e Staphylococcus aureus subsp. aureus ED98 bacteria 100 Picrophilus torridus Thermoplasma volcanium 62 Sulfolobus tokodaii archaea Pyrobaculum aerophilum 100 Mycobacterium tuberculosis H37Rv 100 Streptomyces coelicolor Corynebacterium diphtheriae NCTC 13129 bacteria Escherichia coli K-12 MG1655 81 Saccharomyces cerevisiae 82 Aspergillus clavatus 96 98 Ustilago maydis 521 Laccaria bicolor Schizosaccharomyces pombe Monosiga brevicollis Drosophila melanogaster 61 99 Mus musculus Heterotrophic Homo sapiens NIES-2562 + chromerid 100 10 marinus ATCC 50983 Phytophthora infestans 100 Dictyostelium discoideum 98 Paramecium tetraurelia thermophila Chromera velia CCMP2878 chromerid 85 glacialis CCMP 1383 Symbiodinium sp. CCMP421 Lingulodinium polyedrum CCMP 1738 Heterocapsa rotundata SCCAP K-0483 Peridinium aciculiferum PAER-2 Amphidinium carterae CCMP1314 dinoflagellates 100 Togula jolla CCCM 725 Karenia brevis CCMP2229 Kryptoperidinium foliaceum CCMP 1326 62 58 PBGD Durinskia baltica CSIRO CS-38 68 Hemiselmis andersenii CCMP644 99 Rhodomonas abbreviata_CaronLabIsolate Guillardia theta cryptophytes 61 Lotharella globosa LEX01 95 Gymnochlora sp. CCMP2014 61 Bigelowiella natans CCMP1258.1 chlorarachniophytes 72 Chromera velia CCMP2878 Vitrella brassicaformis CCMP3155 chromerids Emiliania huxleyi 0.2 100 97 Gephyrocapsa oceanica RCC1303 85 Karenia brevis CCMP2229 82 0.4 73 Prymnesium parvum_Texoma1 Chrysochromulina polylepis CCMP1757 haptophytes Isochrysis galbana CCMP 1323 47 89 Karlodinium micrum CCMP2283 44 Karlodinium micrum CCMP2283 35 62 Karlodinium micrum CCMP2283 Karlodinium micrum CCMP2283 98 Durinskia baltica CSIRO CS-38 Ochromonas sp. BG-1 70 Thalassiosira pseudonana 83 Odontella aurita isolate 1302-5 stramenopiles 99 100 Durinskia baltica CSIRO CS-38 Kryptoperidinium foliaceum CCMP 1326 Phaeodactylum tricornutum Aureococcus anophagefferens CCMP1850 Heterosigma akashiwo CCMP 452 Pavlova sp. CCMP459 haptophyte 82 Galdieria sulphuraria Cyanidioschyzon merolae 58 90 Porphyridium aerugineum SAG 1380-2 Rhodosorus marinus UTEX LB 2760 red algae Rhodella maculata CCMP 736 100 Chlamydomonas reinhardtii 87 Volvox carteri f. nagariensis 68 Chlorella variabilis 100 Ostreococcus tauri 78 Micromonas sp. RCC299 green plants 83 Oryza sativa japonica Arabidopsis thaliana marina dinoflagellate Nitrobacter hamburgensis 76 Sphingobium chlorophenolicum Rhodospirillum centenum bacteria 100 Chlamydomonas reinhardtii 69 Volvox carteri f. nagariensis green plants Odontella aurita isolate 1302-5 stramenopile Toxoplasma gondii apicomplexan parasite Streptomyces coelicolor bacterium falciparum 3D7 apicomplexan parasite

94 Chlorarachnion reptans CCCM449 Bigelowiella natans CCMP 2755 100 Lotharella globosa LEX01 chlorarachniophytes Gymnochlora sp. CCMP2014 Monosiga brevicollis MX1 100 Paramecium tetraurelia strain d4-2 Tetrahymena thermophila SB210 Phytophthora infestans T30-4 52 Schizosaccharomyces pombe 8 62 Aspergillus clavatus 83 Saccharomyces cerevisiae Aspergillus clavatus 89 Laccaria bicolor Laccaria bicolor 100 Mus musculus heterotrophic eukaryotes 91 Homo sapiens Drosophila melanogaster + chlorarachniophytes Synechocystis sp. PCC 6803 51 Microcystis aeruginosa Acaryochloris marina Trichodesmium erythraeum 100 Anabaena variabilis Nostoc sp. PCC 7120 100 Prochlorococcus marinus SS120 cyanobacteria Synechococcus sp. WH8102 Acanthamoeba castellanii str.Neff 50 Thermosynechococcus elongatus Dictyostelium discoideum heterotrophic eukaryote Gloeochaete wittrockiana SAG4.46.84 glaucophyte 100 Lepidodinium chlorophorum NIES-1868 Lepidodinium chlorophorum NIES-1868 71 Staphylococcus aureus subsp. aureus ED98 99 Bacillus anthracis_Ames Listeria monocytogenes EGD-e 67 Corynebacterium diphtheriae NCTC 13129 100 Mycobacterium tuberculosis H37Rv Streptomyces coelicolor 100 Ralstonia solanacearum GMI1000 bacteria 100 Burkholderia xenovorans LB400 Neisseria meningitidis Z2491 91 98 Escherichia coli K-12 MG1655 39 97 Vibrio cholerae O395 88 Pseudoalteromonas atlantica Eutreptiella gymnastica NIES-381 euglenid 97 Thermoplasma volcanium 60 Picrophilus torridus 89 Sulfolobus tokodaii 66 archaea Pyrobaculum aerophilum Rickettsia prowazekii bacterium 79 Ostreococcus lucimarinus Micromonas sp. RCC299 100 Volvox carteri f. nagariensis green plants Chlamydomonas reinhardtii Chlorella variabilis UROS Rhodosorus marinus UTEX LB 2760 red alga Vitrella brassicaformis CCMP3155 chromerid

100 Oryza sativa japonica Arabidopsis thaliana green plants Chondrus crispus red alga Pavlova sp. CCMP459 haptophyte Cyanidioschyzon merolae red alga 0.2 37 18 Lepidodinium chlorophorum NIES-1868 82 Chattonella subsalsa CCMP2191 Heterosigma akashiwo CCMP 452 stramenopiles 0.4 93 Rhodomonas lens RHODO Guillardia theta cryptophytes 55 Isochrysis galbana CCMP1323 99 Isochrysis galbana CCMP 1323 Emiliania huxleyi 78 100 Gephyrocapsa oceanica RCC1303 Coccolithus pelagicus ssp braarudi PLY182g haptophytes Phaeocystis antarctica_CaronLabIsolate

100 Chrysochromulina polylepis CCMP1757 Prymnesium parvum_Texoma1 Ochromonas sp. CCMP1393 stramenopile

92 Lotharella globosa LEX01 95 Gymnochlora sp. CCMP2014 100 Bigelowiella natans CCMP1258.1 chlorarachniophytes Chlorarachnion reptans CCCM449 Galdieria sulphuraria red alga Chromera velia CCMP2878 chromerid Symbiodinium sp. CCMP2430 51 Lingulodinium polyedrum CCMP 1738 Heterocapsa rotundata SCCAP K-0483 Gymnodinium catenatum GC744 Alexandrium monilatum CCMP3105 dinoflagellates Karenia brevis 83 76 Togula jolla CCCM 725 Karlodinium micrum CCMP2283 Amphidinium massartii CS-259

66 Odontella aurita isolate 1302-5 Thalassiosira pseudonana CCMP1335 77 99 Durinskia baltica CSIRO CS-38 Kryptoperidinium foliaceum CCMP 1326 Phaeodactylum tricornutum stramenopiles 72 Chaetoceros sp. GSL56 Porphyridium aerugineum SAG 1380-2 red alga 62 Euglena gracilis euglenid Phytophthora infestans Dictyostelium discoideum AX4 87 Aspergillus clavatus 77 Schizosaccharomyces pombe Saccharomyces cerevisiae Acanthamoeba castellanii 93 Laccaria bicolor 99 Mus musculus heterotrophic eukaryotes 69 Homo sapiens + euglenid Drosophila melanogaster Pyrobaculum aerophilum 81 100 Streptomyces coelicolor Mycobacterium tuberculosis H37Rv bacteria Pyrobaculum aerophilum archaea 92 Sulfolobus tokodaii Pyrobaculum aerophilum 93 99 Picrophilus torridus Thermoplasma volcanium 95 Karlodinium micrum CCMP2283 Rhodosorus marinus UTEX LB 2760 red alga 95 99 Anabaena variabilis 98 Nostoc sp. PCC 7120 Acaryochloris marina cyanobacteria 100 Prochlorococcus marinus SS120 88 Synechococcus sp. WH8102 Gloeochaete wittrockiana SAG4.46.84 glaucophyte Staphylococcus aureus subsp. aureus ED98 Bacillus anthracis_Ames bacteria Listeria monocytogenes EGD-e 97 Karlodinium micrum CCMP2283 81 Karlodinium micrum CCMP2283 91 86 Karenia brevis CCMP2229 Karenia brevis CCMP2229 100 Chrysochromulina polylepis UIO037 100 Prymnesium parvum_Texoma1 100 Gephyrocapsa oceanica RCC1303 100 Emiliania huxleyi haptophytes 100 99 Isochrysis galbana CCMP1323 Coccolithus pelagicus ssp braarudi PLY182g 86 Aureococcus anophagefferens CCMP1850 stramenopile Cryptomonas paramecium CCAP977/2a UROD 53 Guillardia theta 66 Hemiselmis andersenii CCMP644 Rhodomonas salina CCMP1319 cryptophytes Odontella aurita isolate 1302-5 Chaetoceros cf. neogracile RCC1993 89 100 Thalassiosira pseudonana 0.2 97 Durinskia baltica CSIRO CS-38 63 75 Kryptoperidinium foliaceum CCMP 1326 Phaeodactylum tricornutum Ectocarpus siliculosus 93 100 Durinskia baltica CSIRO CS-38 stramenopiles 55 Ochromonas sp CCMP1899 0.4 Paraphysomonas_Paraphysomonas imperforata PA2 100 Heterosigma akashiwo CCMP 452 Chattonella subsalsa CCMP2191 Pavlova sp. CCMP459 haptophyte 84 Porphyridium aerugineum SAG 1380-2 Cyanidioschyzon merolae Rhodella maculata CCMP736 red algae Galdieria sulphuraria Chondrus crispus Rhodosorus marinus UTEX LB 2760 70 100 Anabaena variabilis 99 Nostoc sp. PCC 7120 82 Acaryochloris marina 60 70 Microcystis aeruginosa 53 Synechocystis sp. PCC 6803 Trichodesmium erythraeum 50 Thermosynechococcus elongatus cyanobacteria 93 Synechococcus sp. WH8102 50 100 Prochlorococcus marinus SS120 cyanell in Paulinella chromatophora Gloeochaete witrockiana SAG 46.84 glaucophyte 100 Arabidopsis thaliana 68 Oryza sativa japonica 100 Ostreococcus tauri 78 99 Micromonas sp. RCC299 100 Chlamydomonas reinhardtii 97 Volvox carteri f. nagariensis Chlorella variabilis 100 Volvox carteri f. nagariensis green plants 99 Chlamydomonas reinhardtii 100 Chlorella variabilis 100 Arabidopsis thaliana 83 Oryza sativa japonica 92 Ostreococcus tauri Micromonas sp. RCC299 Gloeochaete witrockiana SAG 46.84 glaucophyte 52 Karlodinium micrum CCMP2283 78 Chaetoceros cf. neogracile RCC1993 Lepidodinium chlorophorum NIES-1868 100 Odontella aurita isolate 1302-5 99 Durinskia baltica CSIRO CS-38 Kryptoperidinium foliaceum CCMP 1326 90 Heterosigma akashiwo CCMP 452 stramenopiles Chattonella subsalsa CCMP2191 Aureococcus anophagefferens CCMP1850 Ochromonas sp CCMP1899 100 Ectocarpus siliculosus 100 53 Eutreptiella gymnastica NIES-381 euglenid Karenia brevis CCMP2229 Chromera velia CCMP2878 chromerid 50 Isochrysis galbana CCMP1323 99 Coccolithus pelagicus ssp braarudi PLY182g Prymnesium parvum_Texoma1 Gephyrocapsa oceanica RCC1303 haptophytes 98 Rhodomonas salina CCMP1319 cryptophytes Hemiselmis andersenii CCMP644 Lingulodinium polyedrum CCMP 1738 93 Gymnodinium catenatum GC744 Togula jolla CCCM 725 Amphidinium carterae CCMP1314 Lepidodinium chlorophorum NIES-1868 67 Polarella glacialis CCMP 1383 Symbiodinium sp. CCMP421 dinoflagellates 99 100 66 Durinskia baltica CSIRO CS-38 Kryptoperidinium foliaceum CCMP 1326 57 61 Heterocapsa rotundata SCCAP K-0483 Peridinium aciculiferum PAER-2 Pavlova sp. CCMP459 haptophyte 62 Cyanidioschyzon merolae 70 Porphyridium aerugineum SAG 1380-2 red algae Rhodella maculata CCMP 736 100 Prymnesium parvum_Texoma1 58 Chrysochromulina polylepis UIO037 100 Emiliania huxleyi Gephyrocapsa oceanica RCC1303 79 Isochrysis galbana CCMP 1323 haptophytes Coccolithus pelagicus ssp braarudi PLY182g 39 75 Karlodinium micrum CCMP2283 Karenia brevis CCMP2229 Pavlova sp. CCMP459 58 Guillardia theta Hemiselmis andersenii CCMP644 cryptophytes Eutreptiella gymnastica NIES-381 euglenid Ochromonas sp CCMP1899 100 Heterosigma akashiwo CCMP 452 81 Chattonella subsalsa CCMP2191 stramenopiles Ectocarpus siliculosus 100 Micromonas sp. RCC299 Ostreococcus tauri green plants Durinskia baltica CSIRO CS-38 Lepidodinium chlorophorum NIES-1868 Lepidodinium chlorophorum NIES-1868 Lingulodinium polyedrum CCMP 1738 Symbiodinium sp. CCMP421 Polarella glacialis CCMP 1383 Amphidinium carterae CCMP1314 dinoflagellates Peridinium aciculiferum PAER-2 89 Togula jolla CCCM 725 Gymnodinium catenatum GC744 Heterocapsa rotundata SCCAP K-0483 61 Chaetoceros cf. neogracile RCC1993 56 Odontella aurita isolate 1302-5 60 Thalassiosira pseudonana 100 100 Durinskia baltica CSIRO CS-38 Kryptoperidinium foliaceum CCMP 1326 stramenopiles Phaeodactylum tricornutum 59 Chlorarachnion reptans CCCM449 59 99 Bigelowiella natans CCMP1258.1 63 62 Gymnochlora sp. CCMP2014 Lotharella globosa LEX01 chlorarachniophytes Aureococcus anophagefferens CCMP1850 stramenopile 100 Rhodella maculata CCMP736 Chromera velia CCMP2878 chromerid red algae Porphyridium aerugineum SAG 1380-2 100 Gymnochlora sp. CCMP2014 Lotharella globosa LEX01 chlorarachniophytes 64 Polarella glacialis CCMP 1383 Symbiodinium sp. CCMP421 Heterocapsa rotundata SCCAP K-0483 Peridinium aciculiferum PAER-2 Durinskia baltica CSIRO CS-38 95 Kryptoperidinium foliaceum CCMP 1326 Kryptoperidinium foliaceum CCMP 1326 Amphidinium carterae CCMP1314 Gymnodinium catenatum GC744 90 Lingulodinium polyedrum CCMP 1738 dinoflagellates Alexandrium minutum CCMP113 Togula jolla CCCM 725 100 Lepidodinium chlorophorum NIES-1868 100 Lepidodinium chlorophorum NIES-1868 Karenia brevis CCMP2229 Lepidodinium chlorophorum NIES-1868 100 Gymnodinium catenatum GC744 98 96 Chromera velia CCMP2878 60 Vitrella brassicaformis CCMP3155 chromerids 84 Toxoplasma gondii apicomplexan parasite ATCC 50983 perkinsid 100 Mus musculus Homo sapiens Dictyostelium discoideum 20 Monosiga brevicollis MX1 Phytophthora infestans Drosophila melanogaster 100 Eutreptiella gymnastica NIES-381 Eutreptiella gymnastica NIES-381 euglenids 54 Lotharella globosa LEX01 100 Bigelowiella natans CCMP1258.1 26 Gymnochlora sp. CCMP2014 100 Chlorarachnion reptans CCCM449 Lotharella globosa LEX01 Gymnochlora sp. CCMP2014 90 100 heterotrophic- 72 Chlorarachnion reptans CCCM449 Bigelowiella natans CCMP1258.1 chlorarachniophytes 54 Bigelowiella natans CCMP1258.1 93 eukaryotes 97 Chlorarachnion reptans CCCM449 72 Gymnochlora sp. CCMP2014 Lotharella globosa LEX01 51 Laccaria bicolor Aspergillus clavatus 59 Saccharomyces cerevisiae 32 Schizosaccharomyces pombe Acanthamoeba castellanii 87 Paramecium tetraurelia Tetrahymena thermophila 64 Pseudoalteromonas atlantica 100 Vibrio cholerae O1 biovar_El_Tor N16961 100 Escherichia coli K-12 MG1655 100 Ralstonia solanacearum GMI1000 91 Burkholderia xenovorans LB400 65 Neisseria meningitidis MC58 100 86 Nitrobacter hamburgensis 96 Rhodopseudomonas palustris CGA009 Rhodospirillum centenum Rickettsia prowazekii_Madrid E 95 Listeria monocytogenes EGD-e bacteria 100 Bacillus anthracis_Ames 68 Staphylococcus aureus subsp. aureus N315 95 Corynebacterium diphtheriae NCTC 13129 96 Streptomyces coelicolor Mycobacterium tuberculosis H37Rv 100 Thermoplasma volcanium Picrophilus torridus archaea 74 Kryptoperidinium foliaceum CCMP 1326 90 Durinskia baltica CSIRO CS-38 Phaeodactylum tricornutum Thalassiosira pseudonana Odontella aurita isolate 1302-5 63 Chaetoceros sp. GSL56 stramenopiles 80 Phaeodactylum tricornutum CPOX 64 99 Durinskia baltica CSIRO CS-38 Kryptoperidinium foliaceum CCMP 1326 Odontella aurita isolate 1302-5 55 Hemiselmis andersenii CCMP644 83 Cryptomonas paramecium CCAP977/2a 65 Guillardia theta Guillardia theta cryptophytes 0.2 60 Rhodomonas salina CCMP1319 Hemiselmis andersenii CCMP644 Eutreptiella gymnastica NIES-381 euglenid 97 Lingulodinium polyedrum CCMP 1738 Alexandrium catenella OF101 0.4 61 61 Karenia brevis_Wilson Togula jolla CCCM 725 Amphidinium carterae CCMP1314 56 Symbiodinium sp. CCMP421 Symbiodinium sp. CCMP421 dinoflagellates 98 Heterocapsa rotundata SCCAP K-0483 98 Kryptoperidinium foliaceum CCMP 1326 95 Kryptoperidinium foliaceum CCMP 1326 Durinskia baltica CSIRO CS-38 Paraphysomonas bandaiensis_CaronLabIsolate Ochromonas sp. BG-1 Durinskia baltica CSIRO CS-38 stramenopiles 54 Chlorarachnion reptans CCCM449 100 54 Gymnochlora sp. CCMP2014 Lotharella globosa LEX01 Bigelowiella natans CCMP1258.1 chlorarachniophytes Chrysochromulina polylepis CCMP1757 95 Prymnesium parvum_Texoma1 97 Gephyrocapsa oceanica RCC1303 88 Emiliania huxleyi haptophytes Isochrysis galbana CCMP1323 59 91 Aureococcus anophagefferens CCMP1850 stramenopile Pavlova sp. CCMP459 haptophyte 100 Heterosigma akashiwo CCMP 452 Chattonella subsalsa CCMP2191 stramenopiles Gymnochlora sp. CCMP2014 68 100 Bigelowiella natans CCMP1258.1 65 Chlorarachnion reptans CCCM449 Lotharella globosa LEX01 chlorarachniophytes 98 Chlamydomonas reinhardtii 88 Volvox carteri f. nagariensis Chlorella variabilis 100 Ostreococcus tauri Micromonas sp. RCC299 green plants 100 Oryza sativa japonica Arabidopsis thaliana Porphyridium aerugineum SAG 1380-2 Rhodella maculata CCMP 736 Rhodosorus marinus UTEX LB 2760 Chondrus crispus Cyanidioschyzon merolae 75 Galdieria sulphuraria red algae Gloeochaete wittrockiana SAG4.46.84 glaucophyte Gloeochaete wittrockiana SAG4.46.84 99 Mus musculus 99 Homo sapiens Drosophila melanogaster 81 Chlorarachnion reptans CCCM449 100 Bigelowiella natans CCMP1258.1 chlorarachnio- 53 Gymnochlora sp. CCMP2014 Lotharella globosa LEX01 phytes 84 Schizosaccharomyces pombe Saccharomyces cerevisiae Aspergillus clavatus heterotrophic- 99 Chromera velia CCMP2878 86 Vitrella brassicaformis. CCMP3155 chromerids eukaryotes 75 Toxoplasma gondii apicomplexan parasite 100 Phytophthora infestans Phytophthora infestans 100 Paramecium tetraurelia Tetrahymena thermophila Laccaria bicolor 100 Prochlorococcus marinus SS120 89 Synechococcus sp. WH8102 Thermosynechococcus elongatus Acaryochloris marina Trichodesmium erythraeum 100 Nostoc sp. PCC 7120 cyanobacteria Anabaena variabilis 99 Microcystis aeruginosa Synechocystis sp. PCC 6803 Anabaena variabilis 73 62 Vibrio cholerae O1 biovar_El_Tor_N16961 97 Escherichia coli K-12 MG1655 99 Pseudoalteromonas atlantica 72 100 Burkholderia xenovorans LB400 bacteria Ralstonia solanacearum GMI1000 61 Dictyostelium discoideum 78 glaucophyte heterotrophic eukaryotes 100 Gloeochaete wittrockiana SAG4.46.84 72 Acanthamoeba castellanii + glaucophyte Monosiga brevicollis Rhodopseudomonas palustris CGA009 Nitrobacter hamburgensis 77 52 100 Rhodospirillum centenum Sphingomonas sp. MM-1 bacteria Rickettsia prowazekii_Madrid E Lepidodinium chlorophorum NIES-1868 100 Emiliania huxleyi 60 Gephyrocapsa oceanica RCC1303 91 100 Prymnesium parvum_Texoma1 Isochrysis galbana CCMP1323 haptophytes 70 Aureococcus anophagefferens CCMP1850 stramenopile 100 Lingulodinium polyedrum CCMP 1738 Amphidinium carterae CCMP1314 dinoflagellates Vitrella brassicaformis. CCMP3155 chromerid 69 Thalassiosira pseudonana Chaetoceros sp. GSL56 80 Odontella aurita isolate 1302-5 Phaeodactylum tricornutum stramenopiles 86 Durinskia baltica CSIRO CS-38 60 100 Lepidodinium chlorophorum NIES-1868 Lepidodinium chlorophorum NIES-1868 Chromera velia CCMP2878 chromerid Chattonella subsalsa CCMP2191 stramenopile 98 Hemiselmis andersenii CCMP644 Guillardia theta cryptophytes 100 Chlamydomonas reinhardtii 97 Volvox carteri f. nagariensis 88 Chlorella variabilis 85 Eutreptiella gymnastica NIES-381 green plants Euglena gracilis euglenids 100 97 Chlorarachnion reptans CCCM449 Bigelowiella natans CCMP1258.1 Micromonas sp. RCC299 green plant chlorarachniophytes Chondrus crispus red alga Lingulodinium polyedrum CCMP 1738 Symbiodinium sp. CCMP421 Alexandrium monilatum CCMP3105 Gymnodinium catenatum GC744 Kryptoperidinium foliaceum CCMP 1326 Heterocapsa rotundata SCCAP K-0483 dinoflagellates PPOX Amphidinium carterae CCMP1314 100 76 Lepidodinium chlorophorum NIES-1868 Karenia brevis CCMP2229 99 Togula jolla CCCM 725 100 Micromonas sp. RCC299 Ostreococcus tauri 99 100 Volvox carteri f. nagariensis 65 Chlamydomonas reinhardtii green plants 0.2 92 Chlorella variabilis Arabidopsis thaliana 100 100 Oryza sativa japonica 0.4 Zea mays Gloeochaete wittrockiana SAG4.46.84 glaucophyte 97 Kryptoperidinium foliaceum CCMP 1326 Durinskia baltica CSIRO CS-38 Heterosigma akashiwo CCMP 452 Aureococcus anophagefferens CCMP1850 stramenopiles Odontella aurita isolate 1302-5 Phaeocystis antarctica_Caron_Lab_Isolate Chrysochromulina polylepis CCMP1757 Prymnesium parvum_Texoma1 Lepidodinium chlorophorum NIES-1868 Karlodinium micrum CCMP2283 100 Karenia brevis CCMP2229 haptophytes 100 Gephyrocapsa oceanica RCC1303 Emiliania huxleyi 100 Isochrysis galbana CCMP1323 Chaetoceros sp. GSL56 51 Thalassiosira pseudonana stramenopiles Coccolithus pelagicus ssp braarudi PLY182g haptophyte Phaeodactylum tricornutum stramenopile 100 Eutreptiella gymnastica NIES-381 Euglena gracilis euglenids Ochromonas sp CCMP1899 stramenopile 98 Gymnochlora sp. CCMP2014 80 Lotharella globosa LEX01 100 Bigelowiella natans CCMP1259 chlorarachniophytes Chlorarachnion reptans CCCM449 Pavlova sp. CCMP459 haptophyte Nannochloropsis gaditana 66 Ectocarpus siliculosus stramenopiles Chattonella subsalsa CCMP2191 73 Chromera velia CCMP2878 Vitrella brassicaformis CCMP3155 chromerid 77 Guillardia theta 94 Hemiselmis andersenii CCMP644 cryptophyte 90 Cryptomonas paramecium CCAP977/2a 58 94 Porphyridium aerugineum SAG 1380-2 Chondrus crispus red algae Paraphysomonas bandaiensis_Caron_Lab_Isolate stramenopile 55 Galdieria sulphuraria Cyanidioschyzon merolae red algae 98 100 Synechococcus sp. JA-3-3Ab 70 Synechococcus sp. JA-2-3B'a(2-13) cyanobacteria Trichodesmium erythraeum Hemiselmis andersenii CCMP644 cryptophyte Vitrella brassicaformis CCMP3155 chromerid Rhodosorus marinus UTEX LB 2760 red alga 58 100 Arabidopsis thaliana 95 Zea mays green plants Chondrus crispus red alga Bacillus anthracis_Ame 61 Staphylococcus aureus subsp. aureus N315 100 Bacillus anthracis_Ames bacteria Listeria monocytogenes EGD-e

100 Homo sapiens 64 Mus musculus heterotrophic eukaryotes Drosophila melanogaster + some photosynthetic algae Euglena gracilis euglenid 52 Lotharella globosa LEX01 100 Chlorarachnion reptans CCCM449 chlorarachniophytes 68 Bigelowiella natans CCMP1259 Schizosaccharomyces pombe Acanthamoeba castellanii 61 Alexandrium monilatum CCMP3105 100 Lingulodinium polyedrum CCMP 1738 93 100 82 Togula jolla CCCM 725 dinoflagellates Lepidodinium chlorophorum NIES-1868 Vitrella brassicaformis CCMP3155 chromerid Dictyostelium discoideum Tetrahymena thermophila 68 Kryptoperidinium foliaceum CCMP 1326 Durinskia baltica CSIRO CS-38 Heterocapsa rotundata SCCAP K-0483 Amphidinium carterae CCMP1314 Alexandrium catenella OF101 75 Togula jolla CCCM 725 Lingulodinium polyedrum CCMP 1738 68 Gymnodinium catenatum GC744 FeCH 80 Polarella glacialis CCMP 1383 dinoflagellates 100 99 Symbiodinium sp. CCMP421 Symbiodinium sp. CCMP421 Togula jolla CCCM 725 Polarella glacialis CCMP 1383 100 0.2 91 Lepidodinium chlorophorum NIES-1868 Alexandrium catenella OF101 Porphyridium aerugineum SAG 1380-2 Cyanidioschyzon merolae 0.4 69 73 60 Rhodosorus marinus CCMP 769 32 Chondrus crispus red algae Galdieria sulphuraria Euglena gracilis euglenid Lepidodinium chlorophorum NIES-1868 89 Ralstonia solanacearum GMI1000 Burkholderia xenovorans LB400 Neisseria meningitidis MC58 Pseudoalteromonas atlantica 100 Nitrobacter hamburgensis bacteria 97 Rhodopseudomonas palustris CGA009 Rhodospirillum centenum 100 70 Chromera velia CCMP2878 Vitrella brassicaformis CCMP3155 chromerids Plasmodium falciparum 3D7 apicomplexan parasite 65 Vibrio cholerae O1 biovar_El_Tor N16961 75 Escherichia coli K-12 MG1655 bacteria 100 Lepidodinium chlorophorum NIES-1868 Karenia brevis CCMP2229 100 Mus musculus 56 Homo sapiens Drosophila melanogaster 70 Laccaria bicolor heterotrophic eukaryotes 70 Aspergillus clavatus Saccharomyces cerevisiae Schizosaccharomyces pombe + some photosynthetic Gloeochaete wittrockiana SAG4.46.84 glaucophyte eukaryotes 99 Cryptomonas paramecium CCAP977/2a 82 Guillardia theta cryptophytes Hemiselmis andersenii CCMP644 78 Bigelowiella natans CCMP1258.1 76 Gymnochlora sp. CCMP2014 100 Chlorarachnion reptans CCCM449 chlorarachniophytes 73 97 Lotharella globosa LEX01 Phytophthora infestans Dictyostelium discoideum 100 Paramecium tetraurelia Tetrahymena thermophila 66 Listeria monocytogenes EGD-e 52 Staphylococcus aureus subsp. aureus N315 100 Bacillus anthracis_Ames 73 Bacillus anthracis_Ames 80 Corynebacterium diphtheriae NCTC 13129 bacteria 100 Streptomyces coelicolor Mycobacterium tuberculosis H37Rv 100 Trichodesmium erythraeum Anabaena variabilis cyanobacteria 99 Emiliania huxleyi 94 Gephyrocapsa oceanica RCC1303 54 Isochrysis galbana CCMP 1323 57 Coccolithus pelagicus ssp braarudi PLY182g Prymnesium parvum_Texoma1 haptophytes 89 88 Chrysochromulina polylepis CCMP1757 100 Euglena gracilis Eutreptiella gymnastica NIES-381 euglenids Karenia brevis CCMP2229 Coccolithus pelagicus ssp braarudi PLY182g 85 100 Emiliania huxleyi 95 83 Gephyrocapsa oceanica RCC1303 Isochrysis galbana CCMP 1323 73 78 Prymnesium parvum_Texoma1 haptophytes Chrysochromulina polylepis CCMP1757 Pavlova sp. CCMP459 100 Rickettsia prowazekii_Madrid E Rhodospirillum centenum bacteria Pavlova sp. CCMP459 haptophyte 85 Arabidopsis thaliana 91 Oryza sativa japonica 96 Arabidopsis thaliana Oryza sativa japonica 61 77 Micromonas sp. RCC299 Ostreococcus tauri green plants 70 Chlorella variabilis 99 Chlamydomonas reinhardtii 67 Volvox carteri f. nagariensis 64 Gymnochlora sp. CCMP2014 Chlorarachnion reptans CCCM449 100 Bigelowiella natans CCMP1258.1 chlorarachniophytes Lotharella globosa LEX01 85 Kryptoperidinium foliaceum CCMP 1326 Durinskia baltica CSIRO CS-38 Chaetoceros cf. neogracile RCC1993 92 Odontella aurita isolate 1302-5 Phaeodactylum tricornutum Thalassiosira pseudonana 53 Chattonella subsalsa CCMP2191 Nannochloropsis gaditana Aureococcus anophagefferens CCMP1850 Paraphysomonas bandaiensis_Caron_Lab_Isolate stramenopiles Durinskia baltica CSIRO CS-38 Lepidodinium chlorophorum NIES-1868 Ectocarpus siliculosus 58 Chromera velia CCMP2878 Vitrella brassicaformis CCMP3155 chromerids Hemiselmis andersenii CCMP644 99 Hemiselmis andersenii CCMP644 91 Rhodomonas salina CCMP1319 cryptophytes 51 Guillardia theta 52 Porphyridium aerugineum SAG 1380-2 71 Rhodella maculata CCMP 736 Rhodosorus marinus CCMP 769 red algae Gloeochaete wittrockiana SAG4.46.84 glaucophyte Acaryochloris marina Trichodesmium erythraeum 100 Nostoc sp. PCC 7120 cyanobacteria Anabaena variabilis Synechocystis sp. PCC 6803 67 Karenia brevis CCMP2229 Synechococcus sp. WH8102 cyanell in Paulinella chromatophora 76 Prochlorococcus marinus SS120 cyanobacteria Karlodinium micrum CCMP2283