Curriculum Vitae Prof. Dr. Seyed E. Hasnain

Name: Seyed Ehtesham Hasnain Born: 13 April 1954

Main areas of research: Molecular infection biology, host‐pathogen interaction, tuberculosis, drug resistant tuberculosis, Functional Molecular Epidemiology of Mycobacterium tuberculosis Seyed E. Hasnain is a microbiologist whose main research interest lies in the field of molecular infection biology. He earlier provided important insights into pathogen‐host interaction within the framework of baculovirus infections in insect cells. In other work he researched the epidemiology of tuberculosis pathogens (mycobacterium tuberculosis)

Academic and Professional Career 2012 Visiting Professor at the Institute of Liver and Biliary Sciences (ILBS) in New , 2011 ‐ 2012 Visiting Professor at the King Saud University in Riyadh, Saudi Arabia since 2011 Invited Professor at the Indian Institute of Technology Delhi (IIT), India 2011 ‐ 2014 Visiting Professor at the Indian Institute of Science Education and Research (IISER) Bhopal, India since 2007 Distinguished Research Professor at the Dr Reddy’s Institute of Life Sciences, University of Hyderabad, India 2005 ‐ 2011 Vice Chancellor (President) of the University of Hyderabad, Hyderabad, India 2005 ‐ 2010 Honorary Professor at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Bangalore, India 1999 ‐ 2005 Founder Director of the Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India 1987 ‐ 2001 Scientist at the National Institute of Immunology, India 1982 ‐ 1983 Lecturer at the Botany Department, University of Delhi, India

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1 1981 ‐ 1987 Postdoc at the University of Alberta, Canada, and the Texas A&M University, USA 1980 Ph.D at the Jawaharlal Nehru University, India 1978 M.Phil at the Jawaharlal Nehru University, India 1977 M.Sc at the Magadh University, India 1975 B.Sc at the Magadh University, India

Functions in Scientific Societies and Committees since 2016 Member of the Academic Council, University, since 2015 Member of the Governing Council, Aligarh Muslim University, Aligarh, India Member of the Academic Council, , New Delhi Member of the Academic Council, Jawaharlal Nehru University (JNU), New Delhi Chairman, NIPER Academic Review Committee, Ministry of Petroleum and Chemicals, Govt. of India since 2013 Member, Academic Committee, Institute of Liver and Biliary Sciences(ILBS,) New Delhi Member, Executive Council, Aligarh Muslim University, Aligarh 2013 ‐ 2015 Council of the Indian Institute of Science, Bangalore, India 2013 Member of the Biotechnology Vision Group for UP, Council of Science & Technology, Uttar Pradesh, India 2012 Chairman of the Task Force “Infectious Disease Biology”, Department of Biotechnology (DBT), India since 2012 Member of the Scientific Advisory Board, All India Institute of Medical Science (AIIMS), New Delhi, India 2012 ‐ 2014 Member of the Advisory Board, Elsevier's International Academic, Amsterdam, Netherlands 2011 ‐ 2014 Member of the University Grants Commission 2011 ‐ 2013 Member of Society of the Indian Institute of Science Education and Research (IISER), Bhopal, India since 2010 Member of the Scientific Advisory Council to the Chief Minister of Jammu &Kashmir, Govt. of J&K 2010 ‐ 2015 Chairman, PGIMR Academic Committee, Chandigarh 2010 ‐ 2015 Member, PGIMR Institute Body and Governing Council 2008 ‐ 2012 Member of the Scientific Advisory Committee of the Union Cabinet of the Indian Government

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2 since 2005 Member of the Hyderabad Eye Research Foundation, Hyderabad, India 2005 ‐ 2014 Member of the Scientific Advisory Committee of the Indian Prime Minister 2000 ‐ 2012 Member of the Executive Council, Jamia Hamdard, New Delhi, India

Chairman of the Committee for Global Environment Change and Health of the Indian Council of Medical Research (ICMR), Ministry of Health and Family Welfare, India Member of the Scientific Advisory Board, Indian Council of Medical Research (ICMR), Ministry of Health and Family Welfare, India Member of the Advisory Committee, UGC Academic Staff College, University of Kashmir, India Member of the Advisory Committee, Bhopal Memorial Hospital & Research Centre, Bhopal, India Member of the Scientific Advisory Board, National Institute of Tuberculosis Research (TRC), Madras, India Member of the National Immunology Foundation, New Delhi, India Member at the Foundation Board of the India First Foundation, Mumbai, India Member of the Advisory Board of the Foundation for Liberal and Management Education (FLAME), Pune, India Member of the Review Committee, Tata Institute of Social Sciences, Mumbai, India Member of the Life Sciences Research Development Board, Department of Biotechnology, GoI, India Member of the Board of Directors, Suven Life Sciences, Hyderabad, India Member of the Board of Directors, Dr Reddy’s Institute of Life Sciences, Hyderabad, India Member of the Board of Directors, Ignovision Solutions Pvt. Ltd. Chairman/Member, Search cum Selection Committees for Vice Chancellor of Central/State Universities, Director of National Laboratories Chairman, Bio Science Award Committee, DBT Chairman, ICMR Awards Committee Chairman, High Powered Committee of “Global Environment Change and Human Health” of Indian Council of Medical Research, Ministry of Health Family Welfare, India Chairman, Standing Committee for the Special Package to Bihar for augmentation of S&T Infrastructure, Research, Education and Training in the State Member, Society, Indian Institute of Science Education & Research, Bhopal Member, Executive Council, Central Universities of Orissa, Punjab, Sikkim etc. Member, Council, Indian Institute of Science, Bangalore Member, National Police Mission, Ministry of Home Affairs, Govt. of India

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3 Member, National Agriculture Commission, India Member, Board of Trustees, Indian Institute of Advanced Study, Shimla Member, Advisory Council, National Police Academy, Hyderabad Member, Advisory Council, Ministry of Chemicals & Fertilizers, for developing Human Resource for Pharma Industry including Medical Device & Clinical Research Member, Management Committee of the Southern Regional Centre of Council for Social Development, Hyderabad Member, High Level Committee to implement the recommendation of the Sachar Committee in the field of Education, MHRD, GoI Member, Council of Scientific & Industrial Research XI Plan Committee Member, Scientific Advisory Board, Indian Council of Medical Research (ICMR), Ministry of Health & Family Welfare Member, Ministry of Human Resource Development, Govt. of India, Working Group on University and Higher Education – XI Five Year Plan

Honours and Awarded Memberships 2015 Dr. B. R. Ambedkar Award for Excellence in Biomedical Sciences, Indian Council of Medical Research (ICMR) 2014 Order of Merit of the Federal Republic of Germany 2014 Fellow, American Academy of Microbiology, American Society of Micorbiology (ASM), USA 2014 Doctor of Sciences (h. c.), Amity University, Jaipur 2011 Doctor of Medical Sciences (h. c.), Queen’s University Belfast, UK 2010 Sivananda Eminent Citizen Award of the Sanathana Dharma Charitable Trust, Hyderabad 2010 LIONS International Fellow of Excellence (LIFE) Award, LIONS Clubs International 2010 Award of the Federation of Indian Chambers of Commerce and Industry (FICCI), New Delhi, awarded by the Indian Prime Minister 2009 Robert Koch Fellow of the Robert Koch Institute Berlin 2009 Humboldt Research Prize, Alexander von Humboldt Foundation, Germany 2009 Doctor of Science (h. c.), Assam Central University Silchar 2008 Dr. Yellapragada Subba Row Memorial Award of the Indian National Science Academy (INSA) since 2006 Member of the German National Academy of Sciences Leopoldina 2006 Padma Shri National Civilian Award, awarded by the Indian Prime Minister Nationale Akademie der Wissenschaften Leopoldina www.leopoldina.org

4 2006 J.C. Bose Fellowship, Department of Science and Technology of the Indian Government 2006 Dr Nitya Anand Endowment Lecture for Biomedical Research of the Indian National Science Academy (INSA) 2004 Goyal Award of the Kurukshetra University 2004 Shri Om Prakash Bhasin Award for Science & Technology , Shri Om Prakash Bhasin Foundation for Science & Technology 2002 Dr. K. V. Rao Scientific Society Endowment Oration Award 2001 GD Birla Award For Scientific Research of the KK Birla Foundation 2001 Rustom Ranji Oration Award of the Hyderabad Eye Foundation 2001 Indian Academy of Neurology‐Oration, New Delhi 1999 Platinum Jubilee Lecture Award, Indian Science Congress Association Ranbaxy 1997 Ranbaxy Research Award for Basic Medical Sciences 1997 Golden Jubilee Biotechnology Fellowship Award, Department of Biotechnology of the Indian Government 1995 Shanti Swarup Bhatnagar Prize in Biological Sciences, Council of Scientific and Industrial Research (CSIR) of the Indian Government 1991 NII Award for “Outstanding Basic Research Of The Year” 1992 Professor Uma Kant Sinha Memorial Award, Indian Science Congress Association 1990 YMSA‐88 Young Scientist Award for Biological Sciences 1989 Wood‐Whelan Fellowship Award of the International Union Of Biochemistry and Molecular Biology, USA 1989 WHO Visiting Scientist, NEGRC Institute of Virology, Oxford 1988 IUB‐Travel Award, International Congress of Biochemistry, Czechoslovakia 1983 ‐ 1985 Fellow, Alberta Heritage Foundation for Medical Research, Alberta, Canada

Major Scientific Interests

Seyed E. Hasnain is a microbiologist whose main research interest lies in the field of molecular infection biology. He earlier provided important insights into pathogen‐host interaction within the framework of baculovirus infections in insect cells. In other work he researched the epidemiology of tuberculosis pathogens (mycobacterium tuberculosis) Baculoviruses enter insect larvae by being ingested in their food and result in the death of the insect. As a consequence, these viruses have great importance in biological pest control methods. Seyed E. Hasnain researched the overexpression of genes in the baculovirus expression system and the role played by host factors in this process. His insights made a significant contribution to the

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5 understanding of the mechanism of overexpression. Baculoviruses are used as expression systems in genetic engineering. Interferon and Interleukin 2 are examples of components commercially produced by means of genetic engineering for use in medicines, including a candidate malaria vaccine. His earlier collaborative work on HBV generated some novel findings with clinical applications. Studying the dissemination dynamics, using genetic typing of Mycobacterium tuberculosis (M.tb) isolates from India, Hasnain’s group showed the presence of ancestral isolates as the predominant form circulating in India which could explain the lack of concordance between bacterial load and disease burden in the Indian population. Functional characterization of M.tb hypothetical PE/PPE protein family revealed their importance as diagnostics, vaccine candidates and drug targets. Other areas of Seyed E. Hasnain ́s work include an emphasis on the genetic foundations of antimicrobial drug resistance in the mycobacterium tuberculosis pathogen. In addition, he was able to identify new antigenetic substances in the pathogen. His tuberculosis research with regard to the PE/PPE gene family has led to new molecular targets for medicines. These results are important because there are increasingly more drug‐resistant tuberculosis bacteria strains (MDR, XDR, TDR) as well as a greater incidence of cases of multi‐resistant tuberculosis that are resistant to both of the leading antituberculosis medicines. Seyed E. Hasnain hopes to gain greater insight into the disease’s mechanisms so he can develop new therapies. Seyed E. Hasnain and his team have sequenced another mycobacterium that is being used in the treatment of leprosy and named it as Mycobacterium indicus pranii. Using comparative genomic and proteomic analyses, Hasnain and his group have shown the importance of gene cooption and moonlighting in mycobacterial pathogenesis and evolution. Hasnain has long been committed to the continuance of German‐Indian research links. He was awarded the Federal Cross of Merit (Das Verdienstkreuz, 1.Klasse) of the Federal Republic of Germany for his engagement in this area.

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