sustainability Article A Simple Home-Based Lifestyle Intervention Program to Improve Cardiac Autonomic Regulation in Patients with Increased Cardiometabolic Risk Daniela Lucini 1,2,*, Mara Malacarne 1,2, Wolfgang Gatzemeier 3 and Massimo Pagani 1 1 BIOMETRA Department, University of Milan, 20122 Milan, Italy;
[email protected] (M.M.);
[email protected] (M.P.) 2 Exercise Medicine Unit, Humanitas Clinical and Research Center, 20089 Rozzano, Italy 3 Cancer Center, Humanitas Clinical and Research Center, 20089 Rozzano, Italy;
[email protected] * Correspondence:
[email protected]; Tel.: +39-02-82247449 Received: 22 July 2020; Accepted: 15 September 2020; Published: 17 September 2020 Abstract: Lifestyle modification programs (LMP) represent a new approach to cardiometabolic/ oncologic risk reduction. Successful LMP in clinical practice must be feasible, cost effective, efficacious and consider home-based exercise. Likewise, multiple mechanisms implied in cardiometabolic risk reduction such as cardiac autonomic regulation (CAR) should be easily evidenced, in spite of the computational complexity involved. This goal could be facilitated by employing novel, friendlier, simpler techniques, such as the Autonomic Nervous System Index (ANSI), which can be treated as a proxy of CAR. In this observational study, we introduce a simple LMP (based on cognitive behavioral strategies and patient-tailored prescription of nutrition and home-based exercise, managed by a single physician) into the currently existing clinical practice of secondary cardiometabolic prevention. In 26 subjects, we assessed CAR (autoregressive spectral analysis of cardiovascular variabilities), body mass composition (bioelectrical impedance analysis) and stress perception (questionnaires). After LMP, ANSI and lipid profile were improved; % of fat mass, waist circumference and stress perception were reduced.