Featured Notch Signaling Pathway Related Protein Products Endosome Lysosomal Ligand/NECD Degradation Endocytosis UB Epsin Clathrin Mind Bomb 1 Picalm Dynamin
Extracellular DSL Ligand Non-Canonical Ligands Space NOV/CCN3 NECD CNTN-1 Trans- CNTN-6 Activation DLK-1 Notch DNER Notch MAGP-2 Netrin-1 Thrombospondin-2 Thrombospondin-4 TACE/ γ- NICD ADAM17 Secretase Recycling Complex Cytoplasm α-Adaptin
Cleavage at the Numb Plasma Membrane Notch or Endosome Pre-Processing
Lysosomal NAPA Degradation MFNG RFNG Furin Non-Canonical LFNG Endosome Signaling Bcl-2 γ- IKK Secretase NF-κB Complex Glogi PI3K/Akt/TOR β-Catenin
Notch NICD
POFUT1 Proteasome O-fucose ER Canonical Signaling FBXW7
UB UBUB UB Nucleus NICD NLK
Histone NICD Casein Transcriptional Deacetylases Degradation Corepressors/Linkers Kinase 2 EHMT1/2 DYRK1A Notch Target SKIP Genes CDK8
LSD1 RUNX TACC3 CSL/RBPj Histone 3,4 NRARP
Transcriptionally Histone Repressed Acetyltransferases MAML Notch Target Genes: NICD Positive HES-1/5 Regulators HEY-1 SKIP Histone 3,4 Myc CSL/RBPj Bcl-2 Cyclin D1 Transcriptionally Pre Tα Active www.creativebiomart.net
Notch Signal Pathway
In 1917, Morgan and colleagues found a gene in Drosophila, which is named Notch because of a loss of function that leads to a gap in the edge of wings. Subsequent studies found that Notch is expressed in many species from invertebrates to vertebrates. The structure of Notch families is highly conserved and plays a key role in cell differentiation and development. Up to now, studies have elucidated the major members and core transduction of Notch signaling pathway. However, as the research progresses, it is gradually realized that this pathway is actually in a very complicated regulatory network, which is consistent with its multiple function in development.
Notch signaling is relatively simple compared with other signal pathway because there is no second messenger participation. The existing research proposed the "three-step proteolytic model" of Notch signaling activation. First, Notch is synthesized in the endoplasmic reticulum in a single-stranded precursor pattern, and then is cleaved in the Golgi apparatus by furin-like invertase into large fragments with a molecular mass of 180,000 extracellular regions, and a molecular mass of 120,000 transmembrane domains and small fragments of the intracellular region. These two fragments are combined to become heterodimers via Ca2+ dependent non-covalent bonds and then transported to the cell membrane. When Notch ligand binds to receptor, Notch receptor undergoes proteolysis twice. For the first time, Notch receptors were cut into two fragments by the ADAM metalloprotease family ADAM10 / Kuz or ADAM17 / TACE. The N-terminal cleavage product (extracellular region) is endocytosed by the ligand- expressing cells and the C-terminal cleavage product (active Notch receptor NICD) is subsequently enzymatically released by the γ-secretase complex consisting of presenilin 1/2, Pen-2, Aphl and Nicastrin.
The canonical Notch signal pathway is also known as CBF1 / RBPJκ dependent pathway. CBF1 / RBPJκ is a transcriptional repressor that binds specifically to the DNA sequence "CGTGGGAA" and recruits proteins such as SMRT, SKIP, and type I / II histone deacetylases to form costimulatory complexes and inhibit the transcription of downstream genes. After Notch signaling is activated, NICD is released into the nucleus by the enzyme cleavage reaction, and the co-suppression complex is dissociated by binding of the RAM domain and the ANK repeat to CBF1 / RBPJK and recruitment of SKIP and MAML1 to form the co-active complex and activate the transcription of downstream genes. Many of the target genes for Notch signaling are members of the basic helix-loop-helix transcriptional repressor family, such as HES in mammals, XHey-1 in Xenopus laevis, and recently discovered BLBPs. In addition, a CBF1 / RBPJK independent Notch signal transduction exists.
Notch signaling pathway has a very conservative mechanism in signal transduction, the abnormality of this regulatory mechanism often leads to congenital genetic diseases. It has been confirmed that the mutations of related genes in the Notch signaling pathway are associated with genetic diseases such as CADASIL, Aligile's syndrome and hypogastric hypoplasia.
The main task of future research is to unveil the mechanisms of the complex regulatory networks of Notch signaling, thereby recognizing the basis for the diversity of functions of Notch signaling that will allow us to design more specific approaches and treatment program to specific pathologies resulting from aberrant Notch signaling.
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Featured Protein Products Related to Notch Signal Pathway
Group Cat.No. Product Name Tag Species Source
Recombinant Human MIB1 Protein (5- MIB1-1257H His Human E.coli 332 aa), His-tagged MIB1 Recombinant Human MIB1 Protein, MIB1-5316H GST Human Wheat Germ GST-tagged Recombinant Human CLTC, GST- CLTC CLTC-26707TH GST Human Wheat Germ tagged Mammalian Picalm PICALM-626H Recombinant Human PICALM His Human Cell Recombinant Human DNM1 Protein DNM1-458H His-SUMO Human E.coli (2-245 aa), His-SUMO-tagged DNM1 Recombinant Human DNM1 protein, DNM1-06H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human DNM2, DNM2-18H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human DNM2, His- DNM2 DNM2-26990TH His Human E.coli tagged Recombinant Human DNM2 Protein, DNM2-2786H GST Human Wheat Germ GST-tagged Recombinant Human DNM3, His- DNM3 DNM3-12106H His Human E.coli tagged Recombinant Human NOTCH1 NOTCH1-461H Protein (Ala19-Gln526), HIgG1 Fc- HIgG1 Fc Human HEK293 tagged Notch1 Recombinant Human NOTCH1 NOTCH1-384H Fc Human NS0 protein, Fc-tagged Recombinant Human NOTCH1 NOTCH1-5996H GST Human Wheat Germ Protein, GST-tagged Recombinant Human NOTCH2 NOTCH2-504H His Human Insect Cell Protein, His-tagged Recombinant Human NOTCH2 Notch2 NOTCH2-1814H His Human E.coli protein, His-tagged Recombinant Human NOTCH2 NOTCH2-5997H GST Human Wheat Germ Protein, GST-tagged Recombinant Human NOTCH3 NOTCH3-1813H His/GST Human E.coli protein, His & GST-tagged Recombinant Human Notch NOzTCH3 NOTCH3-2543H Fc Human Sf21 Insect Cell Homolog 3 (Drosophila), Fc Chimera Recombinant Human NOTCH3 NOTCH3-5999H GST Human Wheat Germ Protein, GST-tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human NOTCH4 NOTCH4-523H His Human Insect Cell Protein (Met1-Phe637), His-tagged NOTCH4 Mammalian NOTCH4-309H Recombinant Human NOTCH4 His Human Cell Recombinant Human ADAM17 ADAM17-278H GST Human Wheat Germ Protein, GST-tagged Recombinant Human ADAM ADAM17 ADAM17-592H Metallopeptidase Domain 17, His- His Human Insect Cell tagged Recombinant Human ADAM17 ADAM17-7114H His Human E.coli protein, His-tagged Recombinant Human NOV-1671H Nephroblastoma Overexpressed N/A Human NSO Gene Recombinant Human NOV, His NOV-2211H His Human Insect Cell NOV tagged Recombinant Human NOV, His- NOV-27805TH His Human E.coli tagged Recombinant Human NOV Protein, NOV-6000H GST Human Wheat Germ GST-tagged Recombinant Human CNTN1, GST- CNTN1-11411H GST Human E.coli tagged Recombinant Human CNTN1, Fc- CNTN1-166H Fc Human HEK293 tagged CNTN1 Recombinant Human CNTN1 Protein, CNTN1-3288H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human CNTN1, Fc Fc CNTN1-507H Human Sf21 Insect Cell Chimera Chimera Recombinant Human CNTN6 Protein CNTN6-687H HIgG1 Fc Human HEK293 (Met1-Ser999), HIgG1 Fc-tagged CNTN6 Recombinant Human CNTN6, Fc- CNTN6-26744TH Fc Human HEK293 tagged Recombinant Human DLK1 Protein, DLK1-001H MYC/DDK Human HEK293T MYC/DDK-tagged Recombinant Human DLK1, GST- DLK1-12023H GST Human E.coli tagged DLK1 Recombinant Human DLK1 protein, DLK1-188H His Human HEK293 His-tagged
Recombinant Human DLK1, FLAG- DLK1-26164TH Flag Human HEK293 tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human DLK1, Fc- DLK1 DLK1-26914TH Fc Human HEK293 tagged Recombinant Human DNER, FLAG- DNER-26158TH Flag Human HEK293 tagged Recombinant Human DNER, Fc- DNER DNER-28368TH Fc Human HEK293 tagged Mammalian DNER-835H Recombinant Human DNER His Human Cell Recombinant Human MFAP5 Protein, MFAP5-1243H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human MFAP5 Protein, MFAP5 MFAP5-4387H GST Human Wheat Germ GST-tagged Recombinant Human MFAP5, His His MFAP5-8554H Human Human Cell tagged
NTN1-1088H Recombinant Human NTN1 His Human NS0
Recombinant Human NTN1 Protein, NTN1 NTN1-22H FLAG Human HEK 293 FLAG-tagged Recombinant Human NTN1, Fc- NTN1-428H Fc Human HEK293 tagged Recombinant Human THBS2, His- THBS2-101H His Human NS0 tagged THBS2 Recombinant Human THBS2 protein, THBS2-8253H His/T7 Human E.coli
His & T7-tagged Recombinant Human THBS4, GST- THBS4-121H GST Human Wheat Germ tagged Recombinant Human THBS4 THBS4-507H His Human CHO Thrombospondin 4, His-tagged Recombinant Human THBS4 protein, THBS4-8256H His/GST Human E.coli His & GST-tagged Recombinant Human PSEN1, His- PSEN1-2004H His Human E.coli tagged PSEN1 PSEN1-29963TH Recombinant Human PSEN1 Human Wheat Germ
PSEN2 PSEN2-28527TH Recombinant Human PSEN2 Human Wheat Germ
Recombinant Human APH1A Protein APH1A APH1A-2712H His-SUMO Human in vitro E. coli (1-247 aa), His-SUMO-tagged Recombinant Human NCSTN, His- NCSTN-1217H His Human E.coli tagged NCSTN Recombinant Human NCSTN Protein, NCSTN-469H MYC/DDK Human HEK293 MYC/DDK-tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human AP2A1, His- AP2A1-27357TH His Human E.coli tagged AP2A1 Recombinant Human AP2A1 protein, AP2A1-651H GST Human Wheat Germ GST-tagged Recombinant Human AP2A2, His- AP2A2-3532H His Human E.Coli or Yeast tagged AP2A2 Recombinant Human AP2A2, His- AP2A2-9715H His Human E.coli tagged Recombinant Human NUMB Protein, NUMB-235H His Human E.coli His-tagged NUMB Recombinant Human NUMB Protein, NUMB-236H DDK Human Sf9 Insect Cell DDK-tagged Recombinant Human NAPA protein, NAPA-127H T7 Human E.coli T7-tagged NAPA Recombinant Human NAPA Protein, NAPA-636H His Human E.coli His-tagged Recombinant Human FURIN protein, FURIN-16H His Human NS0 His-tagged Recombinant Human FURIN Protein,
FURIN FURIN-17H His Human HEK293 His-tagged Recombinant Human FURIN Protein, FURIN-4554H GST Human Wheat Germ GST-tagged Recombinant Human MFNG protein, MFNG-1880H His/T7 Human E.coli
His & T7-tagged MFNG Recombinant Human MFNG Protein, MFNG-4379H GST Human Wheat Germ GST-tagged Recombinant Human LFNG Protein LFNG-2140H GST Human E.coli (1-250 aa), GST-tagged LFNG LFNG-29854TH Recombinant Human LFNG Human Wheat Germ
Recombinant Human POFUT1 Protein, POFUT1-206H His Human E.coli His-tagged POFUT1 Recombinant Human POFUT1, His- POFUT1-7213H His Human E.coli tagged Recombinant Human BCL2 Protein, BCL2-143H GST Human Wheat Germ GST-tagged Recombinant Human BCL2 Protein, BCL2-2469H MYC/DDK Human HEK293 BCL2 MYC/DDK-tagged
Mammalian BCL2-264H Recombinant Human BCL2 His Human Cell
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Group Cat.No. Product Name Tag Species Source
Recombinant Human NFKB1 protein, NFKB1-120H T7/His Human E.coli
T7/His-tagged Recombinant Human NFKB1 protein, NFKB1-1847H His/GST Human E.coli His & GST-tagged NFKB1 Recombinant Human NFKB1 protein, NFKB1-300H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human NFKB1 protein, NFKB1-301H His/T7 Human E.coli
His/T7-tagged Recombinant Human NFKB2, GST- NFKB2-1280H GST Human E.coli tagged Recombinant Human NFKB2 protein, NFKB2-306H His/MBP Human E.coli His/MBP-tagged NFKB2 Recombinant Human NFKB2 protein, NFKB2-4859 GST Human Insect Cell GST-tagged Recombinant Human NFKB2 Protein, NFKB2-815H MYC/DDK Human HEK293 MYC/DDK-tagged PIK3CB&PIK3R1- Recombinant Human PIK3CB/PIK3R1 His Human Insect Cell 155H protein, His-tagged, Active PIK3CB Mammalian PIK3CB-620H Recombinant Human PIK3CB His Human Cell Recombinant Human AKT1 Protein, AKT1-14H His Human Insect Cell His-tagged Recombinant Human AKT1 Protein, AKT1-336H His & Strep Human HEK293 His & Strep-tagged AKT1 Recombinant Human AKT1, GST- AKT1-101H GST Human Sf9 Insect Cell tagged Recombinant Human AKT1 protein, AKT1-156H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human AKT2, GST- AKT2-102H GST Human Sf9 Insect Cell tagged, Active AKT2 Recombinant Human AKT2 protein, AKT2-1841H His/T7 Human E.coli
His & T7-tagged Recombinant Human AKT3, GST- AKT3-104H GST Human Sf9 Insect Cell tagged, Active AKT3 Recombinant Human Akt3, His- Akt3-159H His Human E.coli tagged Recombinant Human RORC protein, RORC-5893H His Human E. coli His-tagged Recombinant Human RORC Protein, RORC RORC-02H GST Human Insect Cell GST-tagged Recombinant Human RORC protein, RORC-16H MYC/DDK Human HEK293 MYC/DDK-tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human CTNNB1 Protein CTNNB1-1174H GST Human E.coli (2-781 aa), GST-tagged Recombinant Human CTNNB1 Protein CTNNB1-2514H His Human Yeast (2-781 aa), His-tagged CTNNB1 Recombinant Human CTNNB1 CTNNB1-3375H DDK Human Insect Cell Protein, DDK-tagged Recombinant Human CTNNB1 CTNNB1-3376H MYC/DDK Human HEK293
Protein, MYC/DDK-tagged Recombinant Human NLK Protein, NLK-1010H MYC/DDK Human HEK293 MYC/DDK-tagged NLK Recombinant Human NLK protein, NLK-1066 GST Human Insect Cell GST-tagged Recombinant Human DYRK1A, GST- DYRK1A-19H GST Human Insect Cell tagged Recombinant Human DYRK1A, His- DYRK1A DYRK1A-227H His Human E.coli tagged Recombinant Human DYRK1A DYRK1A-776H DDK Human Sf9 Insect Cell Protein, DDK-tagged Mammalian CSNK2A1-166H Recombinant Human CSNK2A1 His Human Cell Recombinant Human CSNK2A1 CSNK2A1-191H DDK Human Insect Cell protein, DDK-tagged CSNK2A1 Recombinant Human CSNK2A1, GST- CSNK2A1-283H GST Human Sf9 Insect Cell tagged, Active Recombinant Human CSNK2A1 CSNK2A1-3356H MYC/DDK Human HEK293
Protein, MYC/DDK-tagged Recombinant Human CSNK2A2 CSNK2A2-2009H GST/His Human Insect Cell Protein, GST-His-tagged CSNK2A2- Recombinant Human CSNK2A2, MBP- MBP Human E.coli 27169TH tagged CSNK2A2 Recombinant Human CSNK2A2 CSNK2A2-3359H MYC/DDK Human HEK293
Protein, MYC/DDK-tagged Recombinant Human CSNK2A2, Gly CSNK2A2-468H Fc Human Insect Cell & Pro tagged Recombinant Human CSNK2B, GST- CSNK2B-11635H GST Human E.coli tagged CSNK2B Recombinant Human CSNK2B CSNK2B-2013H GST Human Wheat Germ Protein, GST-tagged
Recombinant Human CDK8 Protein, CDK8 CDK8-1038H GST Human Insect Cell GST-Tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human CDK8 Protein, CDK8-1039H His Human Insect Cell His-Tagged CDK8 Recombinant Human CDK8, CDK8-10H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human INPP5K, His- INPP5K-31407TH His Human E.coli tagged INPP5K Recombinant Human INPP5K Protein, INPP5K-5104H GST Human Wheat Germ GST-tagged Recombinant Human HDAC1 Protein HDAC1-549H His-SUMO Human E.coli (1-482 aa), His-SUMO-tagged Recombinant Human HDAC1, His- HDAC1 HDAC1-1339H His Human Insect Cell tagged Recombinant Human HDAC1 HDAC1-1353H GST Human Sf9 Insect Cell (Active), GST-tagged Recombinant Human HDAC2 GST HDAC2-1355H Human Sf9 Insect Cell (Active), GST-tagged HDAC2 Recombinant Human HDAC2, His- HDAC2-28263TH His Human Insect Cell tagged Recombinant Human SIRT1, His SIRT1-1165H His Human E.coli tagged Recombinant Human SIRT1 Protein, SIRT1 SIRT1-11H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human Sirtuin 1, GST- SIRT1-4874H GST Human E.coli tagged Recombinant Human BCL6, GST- BCL6-10185H GST Human E.coli tagged
BCL6-158H Recombinant Human BCL6 Protein Human E.coli
BCL6 BCL6-159H Recombinant Human BCL6 Protein GST Human Wheat Germ
Recombinant Human BCL6, His & Trx- BCL6-252H His/Trx Human E.coli tagged Recombinant Human BCL6 Protein, BCL6-26735TH GST Human E.coli GST-tagged Recombinant Human BEND6 Protein, BEND6-2422H MYC/DDK Human HEK293 MYC/DDK-tagged BEND6 Recombinant human BEND6, His- BEND6-2441H His Human E.coli tagged Recombinant Human CTBP1 Protein, CTBP1-2053H GST Human Wheat Germ GST-tagged CTBP1 Recombinant Human CTBP1 Protein, CTBP1-640H His Human E.coli His-tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human CIR1 Protein,
CIR1 CIR1-1371H GST Human Wheat Germ GST-tagged Recombinant Human NCOR1/HDAC3 NCOR1-16H GST Human Insect Cell Protein, GST-tagged Recombinant Human NCOR1 NCOR1 NCOR1-1705H His/T7 Human E.coli
protein, His & T7-tagged Recombinant Human NCOR1, His- NCOR1-8484H His Human Sf21 Insect Cell tagged Recombinant Human Nuclear NCOR2 NCOR2-1889H GST Human E.coli Receptor Corepressor 2, GST-tagged Mammalian NKAP-435H Recombinant Human NKAP His Human Cell NKAP Recombinant Human NKAP Protein, NKAP-436H GST Human Wheat Germ GST-tagged Recombinant Human EHMT1 protein, EHMT1-181H GST Human Insect Cell GST-tagged, Active EHMT1 Recombinant Human EHMT1, His- EHMT1-27743TH His Human E.coli tagged Recombinant Human EHMT2, GST- EHMT2-177H GST Human Sf9 Insect Cell tagged Recombinant Human EHMT2 Protein, EHMT2-23H His Human E.coli His-tagged EHMT2 Recombinant Human EHMT2 Protein, EHMT2-382H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human EHMT2, FLAG- EHMT2-41H Flag Human Sf9 Insect Cell tagged Recombinant Human RBPJ protein, RBPJ-12H His Human E.coli His-tagged Recombinant Human RBPJ protein, RBPJ RBPJ-13H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human RBPJ, GST- RBPJ-2225H GST Human E.coli tagged Recombinant Human KDM1A protein, KDM1A-15H GST Human E.coli GST-tagged Recombinant Human KDM1A Protein, KDM1A KDM1A-350H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human KDM1A, FLAG- KDM1A-53H Flag Human Sf9 Insect Cell tagged Recombinant Human H3 Histone
H3 H3-324H Human E. coli Protein Recombinant Human H4 Histone
H4 H4-329H Human E. coli Protein
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Group Cat.No. Product Name Tag Species Source
Recombinant Human RUNX1 protein, RUNX1-148H Arg Human E.coli Arginine-tagged Recombinant Human RUNX1, GST- RUNX1 RUNX1-2471H GST Human E.coli tagged Mammalian RUNX1-263H Recombinant Human RUNX1 His Human Cell
RUNX2-28321TH Recombinant Human RUNX2 Human Wheat Germ
RUNX2 RUNX2-30473TH Recombinant Human RUNX2 Human Wheat Germ
Recombinant Human RUNX2 protein, RUNX2-48H His Human E.coli His-tagged Recombinant Human Runt-related RUNX3-2500H His Human Yeast Transcription Factor 3, His-tagged RUNX3 Recombinant Human RUNX3, His- RUNX3-31339TH His Human E.coli tagged Mammalian NRARP-1656H Recombinant Human NRARP His Human Cell NRARP Recombinant Human NRARP Protein, NRARP-6105H GST Human Wheat Germ GST-tagged Recombinant Human MAML1 Protein, MAML1 MAML1-330H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human MAML2, GST- MAML2 MAML2-718H GST Human E.coli tagged Recombinant Human HAT1 Protein, HAT1-4586H GST Human Wheat Germ GST-tagged HAT1 Recombinant Human Histone HAT1-569H His Human E.coli Acetyltransferase 1, His-tagged Recombinant Human HES1 Protein, HES1-141H His Human E.coli His-tagged HES1 Recombinant Human HES1 Protein, HES1-4699H GST Human Wheat Germ GST-tagged Recombinant Human HES5 Protein, HES5-379H His Human E.coli His-tagged HES5 Recombinant Human HES5 Protein, HES5-4705H GST Human Wheat Germ GST-tagged Recombinant Human HEY1, His- HEY1-1539H His Human E.coli tagged Recombinant Human HEY1 Protein,
HEY1 HEY1-260H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human HEY1 Protein, HEY1-467H GST/His Human E.coli GST-His-tagged
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Group Cat.No. Product Name Tag Species Source
Recombinant Human HEY1 Protein,
HEY1 HEY1-4715H GST Human Wheat Germ GST-tagged Recombinant Human MYC, His- MYC-1029H His Human E.coli tagged Recombinant Human MYC protein, MYC MYC-26H MYC/DDK Human HEK293 MYC/DDK-tagged Recombinant Human MYC protein, MYC-79H Arg Human E.coli arginine-tagged Recombinant Human CCND1 Protein, CCND1-483H His-GST Human E. coli His-GST-tagged Recombinant Human CCND1 Protein, CCND1-0658H GST Human Wheat Germ GST-Tagged Recombinant Human CCND1 CCND1 CCND1-171H DDK Human Insect Cell protein, DDK-tagged Recombinant Human CCND1 CCND1-23H MYC/DDK Human HEK293 protein, MYC/DDK-tagged Recombinant Human CCND1 CCND1-24H flag Human Insect Cell protein, Flag-tagged Mammalian PTCRA PTCRA-813H Recombinant Human PTCRA His Human Cell
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