NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Demo Report Patient Name 8756SP-POS Report Issued 10/15/2018 06:43 Patient ID 8756SP-POS Last Report Issued 08/24/2018 09:16 Chain 18001118 Age Not Given DOB Not Given 88888 Gender Not Given Clinical Example Report Attn: IT Department Workorder 18001118 3701 Welsh Road Willow Grove, PA 19090 Received 08/15/2018 07:07

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS Container Type Clear vial Approx Vol/Weight Not Given

Receipt Notes Not frozen as required

Reporting Analysis and Comments Result Units Limit Notes

8756SP Novel Psychoactive Substances (NPS) Screen 1, Serum/Plasma Sample Receipt condition inappropriate for test code: [Not frozen as required]

Analysis by High Performance Liquid Chromatography/Time of Flight-Mass Spectrometry (LC/TOF-MS)

2- See Comment ng/mL 0.10 Synonym(s): Fu-F; Furanylfentanyl Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). Substance(s) known to interfere with the identity and/or quantity of the reported result: Azithromycin. 3-Fluorophenmetrazine None Detected ng/mL 5.0 Synonym(s): 3-FPM 3-MeO-PCP None Detected ng/mL 5.0 Synonym(s): 3-Methoxy- 4-MeO-PCP None Detected ng/mL 5.0

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Page 1 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

Synonym(s): 4-Methoxy-Phencyclidine 25B-NBOMe None Detected ng/mL 1.0 Synonym(s): -B-NBOMe 25C-NBOMe None Detected ng/mL 1.0 Synonym(s): 2C-C-NBOMe 25H-NBOMe None Detected ng/mL 1.0 Synonym(s): 2C-H-NBOMe 25I-NBOMe None Detected ng/mL 1.0 Synonym(s): 2C-I-NBOMe Acetyl None Detected ng/mL 0.50 Acryl Fentanyl None Detected ng/mL 0.10 -PVP None Detected ng/mL 2.0 Synonym(s): alpha-pyrrolidinopentiophenone; alpha- pyrrolidinopentiophenone Alpha-PVP is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution Bromazepam None Detected ng/mL 5.0 None Detected ng/mL 10 Butyrylfentanyl See Comment ng/mL 0.10 Synonym(s): Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). BZP None Detected ng/mL 10 Synonym(s): 1- None Detected ng/mL 0.10 Synonym(s): Wildnil® cis-3-methylfentanyl See Comment ng/mL 0.10 Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). Clephedrone None Detected ng/mL 50 Synonym(s): 4-chloromethcathinone; 4-CMC

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Page 2 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

Clephedrone is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. Clonazolam None Detected ng/mL 5.0 Clonazolam is known to have limited stability in serum/plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. See Comment ng/mL 0.50 Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). Delorazepam None Detected ng/mL 5.0 Synonym(s): Chlordesmethyldiazepam; Cloxazolam metabolite Deschloroetizolam None Detected ng/mL 2.0 Dibutylone None Detected ng/mL 10 Synonym(s): bk-DMBDB Diclazepam None Detected ng/mL 20 Diclazepam is known to have limited stability in serum/plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. None Detected ng/mL 10 Ethylone is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. Etizolam None Detected ng/mL 10 Flubromazepam None Detected ng/mL 20 Flubromazolam None Detected ng/mL 5.0 Isobutyrylfentanyl See Comment ng/mL 0.10 Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). MDPV None Detected ng/mL 10 Synonym(s): Methylenedioxypyrovalerone

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Page 3 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

MDPV is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. Meclonazepam None Detected ng/mL 5.0 Meclonazepam is known to have limited stability in serum/plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. None Detected ng/mL 10 Synonym(s): 4-methylmethcathinone Mephedrone is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. meta-Methylmethoxyacetylfentanyl See Comment ng/mL 0.50 Synonym(s): 3-Methylmethoxyacetylfentanyl Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). None Detected ng/mL 2.0 Methoxetamine is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. Methoxyacetylfentanyl See Comment ng/mL 0.50 Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). Methoxphenidine None Detected ng/mL 5.0 Synonym(s): MXP None Detected ng/mL 10 Methylone is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. None Detected ng/mL 10 Synonym(s): Kratom MPHP None Detected ng/mL 10

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Page 4 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

Synonym(s): 4'-methyl-alpha-Pyrrolidinohexiophenone MPHP is known to have limited stability in serum/plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. N-Ethyl None Detected ng/mL 10 ortho-Fluorofentanyl None Detected ng/mL 0.10 para-Fluorobutyrylfentanyl See Comment ng/mL 0.10 Synonym(s): 4F-butyryl fentanyl Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). para-Fluorofentanyl None Detected ng/mL 0.10 para-Fluoroisobutyrylfentanyl See Comment ng/mL 0.10 Synonym(s): FIBF; 4F-Isobutyrylfentanyl Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). para-Methylmethoxyacetylfentanyl None Detected ng/mL 0.50 Synonym(s): 4-Methylmethoxyacetylfentanyl None Detected ng/mL 2.0 Pentedrone is known to have limited stability in serum and plasma which may be dependent upon pH, collection tube, and storage temperature. Negative results should be interpreted with caution. Pentylone None Detected ng/mL 10 Phenazepam None Detected ng/mL 10 Pyrazolam None Detected ng/mL 5.0 TFMPP None Detected ng/mL 10 Synonym(s): 3-Trifluoromethylphenylpiperazine THF-F See Comment ng/mL 0.20 Synonym(s): Tetrahydrofuran fentanyl Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). trans-3-Methylfentanyl See Comment ng/mL 0.10

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Page 5 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). U-47700 None Detected ng/mL 1.0 Synonym(s): U-4 U-49900 See Comment ng/mL 1.0 Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). U-51754 See Comment ng/mL 1.0 Comment: Based on this screening result, confirmation testing was performed. Refer to the confirmation test result(s). Valeryl Fentanyl None Detected ng/mL 0.50

52320SP and Stimulants Confirmation 2 (Qualitative), Serum/Plasma Sample Receipt condition inappropriate for test code: [Not frozen as required]

Analysis by Gas Chromatography/Mass Spectrometry (GC/MS)

3-Fluorophenmetrazine Positive ng/mL 5.0 Synonym(s): 3-FPM 3-Fluorophenmetrazine is a stimulant that is closely related to and has been sold online as a novel psychoactive substance. 3-MeO-PCP Positive ng/mL 10 Synonym(s): 3-Methoxy-Phencyclidine 3-Methoxyphencyclidine (3-MeO-PCP) is a that is structurally similar to phencyclidine (PCP) and has been described as having effects similar to those of PCP. Phencyclidine is a dangerous anesthetic. No studies have been performed to evaluate the pharmacological effects of 3-MeO-PCP. 4-MeO-PCP Positive ng/mL 10 Synonym(s): 4-Methoxy-Phencyclidine

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Page 6 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

4-Methoxyphencyclidine (4-MeO-PCP) is a designer drug that is structurally similar to phencyclidine (PCP) and has been described as having effects similar to those of PCP. Phencyclidine is a dangerous dissociative anesthetic. No studies have been performed to evaluate the pharmacological effects of 4-MeO-PCP. Clephedrone Positive ng/mL 50 Synonym(s): 4-chloromethcathinone; 4-CMC Clephedrone is a substituted sold as a novel psychoactive substance. Due to its structural similarities to other such as mephedrone, clephedrone is expected to have stimulant type effects. Methoxphenidine Positive ng/mL 5.0 Synonym(s): MXP Methoxphenidine is a dissociative type drug that is sold as a novel psychoactive substance. Adverse effects noted in analytically confirmed cases of methoxphenidine were similar to those reported for other dissociative substances such as and methoxetamine; these may include hallucinations, delirium, irrational behavior, and/or dream-like states, along with profound analgesia and cardiovascular stimulation.

52488SP Designer Confirmation (2019 Scope), Serum/Plasma

Analysis by High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)

Methoxyacetylfentanyl 5.0 ng/mL 0.050 Methoxyacetylfentanyl is a novel non-prescription synthetic . 4-ANPP 5.0 ng/mL 0.10 Synonym(s): Despropionyl fentanyl 4-ANPP (despropionylfentanyl) is a precursor chemical used in the production of fentanyl/fentanyl related compounds and is also a fentanyl metabolite and may be a metabolite of other fentanyl-related compounds. It is considered to be pharmacologically weak. THF-F 5.0 ng/mL 0.050

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Page 7 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

Synonym(s): Tetrahydrofuran fentanyl THF-F is a novel non-prescription synthetic opioid. meta-Methylmethoxyacetylfentanyl 5.0 ng/mL 0.050 Synonym(s): 3-Methylmethoxyacetylfentanyl Meta-Methylmethoxyacetylfentanyl is a novel non-prescription synthetic opioid. para-Methylmethoxyacetylfentanyl 5.0 ng/mL 0.050 Synonym(s): 4-Methylmethoxyacetylfentanyl Para-Methylmethoxyacetylfentanyl is a novel non-prescription synthetic opioid. Acryl Fentanyl 5.0 ng/mL 0.050 Synonym(s): Acryloylfentanyl is a novel non-prescription synthetic opioid. para-Fluorofentanyl 5.0 ng/mL 0.050 Synonym(s): 4-Fluorofentanyl Para-Fluorofentanyl is a novel non-prescription synthetic opioid. Substance(s) known to interfere with the identity and/or quantity of the reported result: Meta-fluorofentanyl ortho-Fluorofentanyl 5.0 ng/mL 0.050 Synonym(s): 2-Fluorofentanyl Ortho-Fluorofentanyl is a novel non-prescription synthetic opioid. Substance(s) known to interfere with the identity and/or quantity of the reported result: ortho-fluorobutyrylfentanyl impurity 2-Furanylfentanyl 5.0 ng/mL 0.050 Synonym(s): Fu-F; Furanylfentanyl 2-Furanylfentanyl is a novel non-prescription synthetic opioid. U-47700 5.0 ng/mL 0.050 Synonym(s): U-4

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Page 8 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

U-47700 is a novel non-prescription synthetic opioid. U-49900 5.0 ng/mL 0.050 U-49900 is a novel non-prescription synthetic opioid. U-51754 5.0 ng/mL 0.050 U-51754 is a novel non-prescription synthetic opioid. Carfentanil 5.0 ng/mL 0.050 Synonym(s): Carfentanyl; Wildnil® Carfentanil is an opioid used to immobilize large animals. It is not approved for human use. Cyclopropylfentanyl 5.0 ng/mL 0.050 Cyclopropylfentanyl is a novel non-prescription synthetic opioid. Substance(s) known to interfere with the identity and/or quantity of the reported result: Crotonylfentanyl impurity trans-3-Methylfentanyl 5.0 ng/mL 0.050 Trans-3-Methylfentanyl is a novel non-prescription synthetic opioid. Trans-3-methylfentanyl is typically found in combination with its isomer, cis-3-methylfentanyl. Substance(s) known to interfere with the identity and/or quantity of the reported result: crotonyl fentanyl cis-3-Methylfentanyl 5.0 ng/mL 0.050 Cis-3-Methylfentanyl is a novel non-prescription synthetic opioid. Cis-3-methylfentanyl is typically found in combination with its isomer, trans-3-methylfentanyl. Isobutyrylfentanyl 5.0 ng/mL 0.050 Synonym(s): Isobutyrfentanyl Isobutyrylfentanyl is a novel non-prescription synthetic opioid. Substance(s) known to interfere with the identity and/or quantity of the reported result: beta-methylfentanyl Butyrylfentanyl 5.0 ng/mL 0.050

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Page 9 of 10 NMS v.39.0 NMS Labs CONFIDENTIAL 3701 Welsh Road, PO Box 433A, Willow Grove, PA 19090-0437 Phone: (215) 657-4900 Fax: (215) 657-2972 e-mail: [email protected] Robert A. Middleberg, PhD, F-ABFT, DABCC-TC, Laboratory Director

Sample ID 18001118-001 Collect Dt/Tm Not Given Matrix Serum or Plasma Source Not Given Patient Name 8756SP-POS Patient ID 8756SP-POS

Reporting Analysis and Comments Result Units Limit Notes

Synonym(s): Butyrfentanyl Butyrylfentanyl is a novel non-prescription synthetic opioid. para-Fluoroisobutyrylfentanyl 5.0 ng/mL 0.050 Synonym(s): FIBF; 4F-Isobutyrylfentanyl FIBF is a novel non-prescription synthetic opioid. para-Fluorobutyrylfentanyl 5.0 ng/mL 0.050 Synonym(s): 4F-butyrylfentanyl Para-fluorobutyrylfentanyl is a novel non-prescription synthetic opioid. Substance(s) known to interfere with the identity and/or quantity of the reported result: meta-fluorobutyryl fentanyl Valeryl Fentanyl 5.0 ng/mL 0.050 Synonym(s): Pentylfentanyl Valeryl fentanyl is a novel non-prescription synthetic opioid.

Page 10 of 10 NMS v.39.0