Anti-FZR1 Monoclonal Antibody, Clone BS49.3 (DCABH-9823) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-FZR1 monoclonal antibody, clone BS49.3 (DCABH-9823) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to FZR1

Antigen Description Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Immunogen Recombinant full length protein

Isotype IgG1

Source/Host Mouse

Species Reactivity Mouse, Human

Clone BS49.3

Purity IgG fraction

Conjugate Unconjugated

Applications WB, ELISA

Format Liquid

Size 100 μg

Buffer Preservative: None; Constituents: PBS

Preservative None

Storage store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Ship Shipped at 4°C.

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Gene Name FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) [ Homo sapiens ]

Official Symbol FZR1

Synonyms FZR1; fizzy/cell division cycle 20 related 1 (Drosophila); fizzy-related protein homolog; CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1; KIAA1242; CDC20-like 1b; cdh1/Hct1 homolog; CDC20-like protein 1;

Entrez Gene ID 51343

Protein Refseq NP_001129669

UniProt ID Q9UM11

Chromosome Location 19p13.3

Pathway APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C- mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem;

Function kinase activity; protein binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]