Avishay Grupper, M.D.

CURRICULUM VITAE

Name: Avishay Grupper, M.D.

Hospital/Dept.: Heart Failure Institute, Leviev Heart Center, , Tel-Hashomer, Tel No (Office): +972-3-530-4550 Tel No: (Cell): +972-52-666-9115

E-Mail: [email protected]

Date & Place of Birth: 04/30/1975 , Israel (date) (city,country)

Marital Status: Married No. of Children: 3

A. EDUCATION

Period of Study Name of University Subject Degree Date (Dates) Awarded

1997-2000 Hadassah Medical Medicine B.Med.Sc 2001 School, The Hebrew University of 1997-2005 Hadassah Medical Medicine M.D. 2005 School, The Hebrew University of Jerusalem

Date of receiving Specialization Certificate

2010 Specialization certificate in Internal Medicine, Isreal

2013 Specialization certificate in Cardiology, Isreal

B. FURTHER STUDIES

2002 Guest medical student, as part of students exchange program, at the Mount Sinai , Manhattan, NY students program, at the University of Massachusetts 2003 Advanced Cardiac Life Support (ACLS), AHA Certified Course, Hadassah Medical Center, Jerusalem

2006 Medical Officer Trainig Course, Military School of Medicine, Israel Defence Forces (IDF)

2008 Advanced Trauma Life Support (ATLS), Military School of Avishay Grupper, M.D.

Medicine, IDF

2010 Advanced Cardiac Life Support (ACLS), Sheba Medical Center, Tel Hashomer

2010-2012 Continuing medical education in Cardiology, Sackler Faculty of Medicine, University, Tel Aviv

2013 Advanced Cardiac Life Support (ACLS), Sheba Medical Center, Tel Hashomer

2013 Course for Physicians in the Performance of Clinical Trials and Proper Clinical Practice – GCP (Good Clinical Practice), Israel Medical Association,

C. CLINICAL EXPERIENCE

04/2004-04/2005 Internship, Poriya Medical Center, affiliated to the Faculty of Medicine Bar Ilan University, , Israel

09/2005-09/2009 Internal Medicine residency, Internal Medicine T, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel

06/2008-12/2008 Basic science training in the nephrology and vascualr laboratory, Tel Aviv Sourasky Medical Center

01/2010-01/2013 Cardiology residency, Heart Institute, Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel-Hashomer, Israel

06/2006- present Military Physician, Lieutenant in the IDF Special Forces (on reserve)

07/2013– 07/2015 Advanced Heart failure, VAD and Heart Transplantation Fellowship, Mayo Clinic, Rochester MN, USA

D. ACADEMIC AND PROFESSIONAL EXPERIENCE

1999-2002 Instructor, Shahar institute for the university examination entrance test ("Isreali S.A.T's")

2006 Internal Medicine T, Tel Aviv Sourasky Medical Center- New York American Student Program 4th year medical students – Clinical rotation head tutor

2007 Internal Medicine T, Tel Aviv Sourasky Medical Center- medical students clinical rotation head tutor

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2007 Internal Medicine T, Tel Aviv Sourasky Medical Center- medical students clinical rotation head tutor

2009 Internal Medicine T, Tel Aviv Sourasky Medical Center- medical students clinical rotation head tutor

2009 Internal Medicine T, Chief Resident

2011 Heart Institute, Sheba Medical Center, Tel Hashomer –medical students academic Instructor

2012 Heart Institute, Sheba Medical Center, Tel Hashomer –medical students cardiology rotation head tutor

2015 Heart Institute, Sheba Medical Center, Tel Hashomer –medical students academic Instructor

2015 Sackler Faculty of Medicine, Tel Aviv University - medical students academic Instructor

2016 Heart Institute, Sheba Medical Center, Tel Hashomer –medical students academic Instructor

2016 Sackler Faculty of Medicine, Tel Aviv University - medical students academic Instructor

E. ACADEMIC AND PROFESSIONAL AWARDS

2007 Most evaluated clinical teachers in Sackler Faculty of Medicine, Tel Aviv University, Israel

2009 Most evaluated clinical teachers in Sackler Faculty of Medicine, Tel Aviv University,Israel

2014 Outstanding research in the heart failure field, 2nd place, The Annual Heart Failure Symposium, Northwestern Memorial Hospital, Chicago, IL

2014 Mayo Clinic Scorlarship from the Israeli Heart Society

2015 Poster of distiction, The American Transplant Society annual meeting, Philadelphia, PA

2015 Most exciting and innovative abstract, The American Transplant Society annual meeting, Philadelphia, PA

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F. MEMBERSHIP IN PROFESSIONAL SOCIETIES

2012 – present Israel Heart Society

2014 - present International Society of Heart & Lung Transplant (ISHLT)

G. ACTIVE PARTICIPATION IN SCIENTIFIC MEETINGS

2005 the XII Congress of the Israeli Society for Quality in Tel Aviv, Israel Medicine

2012 33rd Annual Heart Rhythm Society Conference Boston, MA

2012 59th Israel Heart Society, Annual Scientific Meeting Tel Aviv, Israel

2012 Cardiostim, European Society of Electrophysiology, 18th Nice, France Annual Scientific Meeting

2013 60th Israel Heart Society, Annual Scientific Meeting Jerusalem. Israel

2014 ISHLT 34th annual meeting San-Diego, CA

2014 The 10th Annual Northwestern Memorial Hospital Chicago, IL Heart Failure Symposium

2015 American College of Cardiology (ACC) 2015 Scientific San Diego, CA Meeting

2015 Women’s Health Annual Meeting Washington DC

2015 American Transplant Society Conference Philadelphia, PA

2016 63rd Israeli Heart Society, Annual Scientific Meeting Tel Aviv, Israel

2016 ISHLT 36th annual meeting Washington DC

H.1. Original Articles:

1. Grupper A, Nativi-Nicolau J, Maleszewski JJ, Geske JR, Kremers WK, Edwards BS, Kushwaha SS, Pereira NL. Circulating Galectin-3 Levels Are Persistently

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Elevated After Heart Transplantation and Are Associated With Renal Dysfunction. JACC Heart Fail. 2016;4:847-856.

2. Nestorovic EM, Grupper A, Joyce LD, Milic NM, Stulak JM, Edwards BS, Pereira NL, Daly RC, Kushwaha SS. Effect of Mechanical Circulatory Support on Cellular and Antibody-Mediated Rejection following Cardiac Transplantation. Am J Cardiol 2016.

3. Grupper A, Grupper A, Daly RC, Pereira NL, Hathcock MA, Kremers WK, Cosio FG, Edwards BS, Kushwaha SS. Kidney transplantation as a therapeutic option for End Stage Renal Disease after Heart Transplantation. J Heart Lung Transplant. 2016.

4. Grupper A, Nestorovic EM, Daly RC, Milic NM, Joyce LD, Stulak JM, Joyce DL, Edwards BS, Pereira NL, Kushwaha SS. Sex Related Differences in the Risk of Antibody-Mediated Rejection and Subsequent Allograft Vasculopathy Post- Heart Transplantation: A Single-Center Experience. Transplantation Direct 2016 13;2:e106 .

5. Grupper A, Zhao YM, Joyce LD, Park SJ, Pereira NL, Stulak JM, Maltais S, Sajgalik P, Burnett JC, Edwards BS, Daly RC, Kushwaha SS, Schirger JA. Neurohormonal Blockade Drug Therapy after Left Ventricular Assist Device Implantation is Associated with Reverse Cardiac Remodeling and Improved Outcomes. Am J Cardiol 2016;117(11):1765-70..

6. Grupper A, Park SJ, Pereira NL, Schettle SD, Gerber Y, Topilsky Y, Edwards BS, Daly RC, Stulak JM, Joyce LD, Kushwaha SS. Role of VAD Therapy for Patients with Restrictive Cardiomyopathy: Improving Outcomes for a Lethal Disease. J Heart Lung Transplant. 2015; 34:1042-9.

7. Grupper A, Killu AM, Friedman PA, Abu Sham'a R, Buber J, Kuperstein R, Rozen G, Asirvatham SJ, Espinosa RE, Luria D, Webster TL, Brooke KL, Hodge DO, Wiste HJ, Cha YM, Glikson M. Effects of Tricuspid Valve Regurgitation on Outcome among Patients with Cardiac Resynchronization Therapy. Am J Cardiol. 2015;115:783-9.

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8. Maor E, Beigel R, Grupper A, Kuperstein R, Hai I, Goldenberg I, Feinberg M, Ben Zekry S. Low Stroke Volume Index is an Independent Predictor of Mortality among Patients with Low Gradient Severe Aortic Stenosis and Preserved Left Ventricle Function. Am J Cardiol. 2014;114:449-55.

9. Grupper A, Beigel R, Maor E, Kuperstein R, Hai I, Perelshtein O, Goldenberg I, Feinberg M, Ben Zekry S. Survival Following Intervention in Patients with Low Gradient Severe Aortic Stenosis and Preserved Left Ventricle Function. J Thorac Cardiovasc Surg. 2014;148:2823-7.

10. Killu AM, Grupper A, Friedman PA, Powell BD, Asirvatham SJ, Espinosa RE, Luria D, Rozen G, Buber J, Lee YH, Webster T, Brooke KL, Hodge DO, Wiste HJ, Glikson M, Cha YM. Predictors and Outcomes of 'Super-Response' to Cardiac Resynchronization Therapy. J Card Fail. 2014;20:379-86.

11. Naftali-Shani N, Itzhaki-Alfia A, Landa-Rouben N, Kain D, Holbova R, Adutler- Lieber S, Molotski N, Asher E, Grupper A, Millet E, Tessone A, Winkler E, Kastrup J, Feinberg MS, Zipori D, Pevsner-Fischer M, Raanani E, Leor J. The origin of human mesenchymal stromal cells dictates their reparative properties. J Am Heart Assoc. 2013; 2:e000253.

12. Buber J, Luria D, Sternik L, Kuperstein R, Grupper A, Goldenberg I, Raanani E, Feinberg MS, Nof E, Eldar M, Glikson M. Morphological features of the P-waves at surface electrocardiogram as surrogate to mechanical function of the left atrium following a successful modified Maze procedure. Europace. 2013; 16:578-86.

13. Abu Sham'a R, Buber J, Grupper A, Nof E, Kuperstein R, Luria D, Feinberg MS, Eldar M, Glikson M. Effects of Tricuspid Valve Regurgitation on Clinical and Echocardiographic Outcome in Patients with Cardiac Resynchronization

Therapy. Europace. 2013; 15:266-72.

14. Schwartz IF, Grupper A, Chernichovski T, Grupper A, Hillel O, Engel A, Schwartz D: Hyperuricemia attenuates aortic nitric oxide generation, through inhibition of arginine transport, in rats. J Vasc Res. 2011; 48:252-60.

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15. Schwartz IF, Chernichovski T, Krishtol N, Grupper A, Laron I, Schwartz D: Sexual dimorphism in glomerular arginine transport affects nitric oxide generation in old male rats. Am J Physiol Renal Physiol. 2009; 297:F80-4.

16. Grupper A, Grupper A, Rudin D, Drenger B, Varon D, Gilon D, Gielchinsky Y, Menashe M, Mintz Y, Rivkind A, Brezis M: Prevention of perioperative venous thromboembolism and coronary events: differential responsiveness to an intervention program to improve guidelines adherence. Int J Qual Health Care. 2006; 18:123-6.

H. 2. Review papers:

1. Grupper A, Gewirtz H, Kushwaha S. Re-innervation post Cardiac Transplantation. European Heart Journal, 2016.

2. Pavol Sajgalik, Avishay Grupper, Brook S. Edwards, Sudhir S. Kushwaha, John M. Stulak, David L. Joyce, Lyle D. Joyce, MD, Richard C. Daly, Tomas Kara, John A. Schirger. Current Status of Left Ventricular Assist Device Therapy. Mayo Clinic Proceedings 2016.

H. 3. Editorial comments: 1. Kushwaha SS, Grupper A. Suspected ARVC in the Athlete – Do T Wave Findings Really Help in Diagnosis? J Am Coll Cardiol. 2015;65:2712-3

H.4. Chapter in book:

1. Grupper A, Boilson BA. Congestive Heart Failure and the Role of Left Ventricular Assist Devices. In: High K and Pulido JN, editors. Mechanical Circulatory Support: Ventricular Assist Devices (VADs) and Extracorporeal Membrane Oxygenation (ECMO). Hershey, PA: A Society of Cardiovascular Anesthesiologists Monograph, 2014.

2. Grupper A, Gewirtz H, Kushwaha SS. Cardiac transplantation: denervation, reinnervation, and myocardial blood flow. In: Dilsizian V. and Narula J, editors. Atlas of Cardiac Innervation. Westmont, NJ: Springer International Publishing, 2016.

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I.5. Letter to the Editor:

1. Grupper A, Brezis M: Resistance to use of perioperative beta-blockers: a no- man's land. Arch Intern Med. 2005; 165:347.

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