Incorporating Judgement in Fan Charts
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The Open Chromatin Landscape of Non–Small Cell Lung Carcinoma
Published OnlineFirst June 17, 2019; DOI: 10.1158/0008-5472.CAN-18-3663 Cancer Genome and Epigenome Research The Open Chromatin Landscape of Non–Small Cell Lung Carcinoma Zhoufeng Wang1, Kailing Tu2, Lin Xia2, Kai Luo2,Wenxin Luo1, Jie Tang2, Keying Lu2, Xinlei Hu2, Yijing He2, Wenliang Qiao3, Yongzhao Zhou1, Jun Zhang2, Feng Cao2, Shuiping Dai1, Panwen Tian1, Ye Wang1, Lunxu Liu4, Guowei Che4, Qinghua Zhou3, Dan Xie2, and Weimin Li1 Abstract Non–small cell lung carcinoma (NSCLC) is a major cancer identified 21 joint-quantitative trait loci (joint-QTL) that type whose epigenetic alteration remains unclear. We ana- correlated to both assay for transposase accessible chroma- lyzed open chromatin data with matched whole-genome tin sequencing peak intensity and gene expression levels. sequencing and RNA-seq data of 50 primary NSCLC cases. Finally, we identified 87 regulatory risk loci associated with We observed high interpatient heterogeneity of open chro- lung cancer–related phenotypes by intersecting the QTLs matin profiles and the degree of heterogeneity correlated to with genome-wide association study significant loci. In several clinical parameters. Lung adenocarcinoma and lung summary, this compendium of multiomics data provides squamous cell carcinoma (LUSC) exhibited distinct open valuable insights and a resource to understand the land- chromatin patterns. Beyond this, we uncovered that the scape of open chromatin features and regulatory networks broadest open chromatin peaks indicated key NSCLC genes in NSCLC. and led to less stable expression. Furthermore, we found that the open chromatin peaks were gained or lost together Significance: This study utilizes state of the art genomic with somatic copy number alterations and affected the methods to differentiate lung cancer subtypes. -
Fan Chart – a Tool for NBP’S Monetary Policy Making
NBP Working Paper No. 241 Fan chart – a tool for NBP’s monetary policy making Paweł Pońsko, Bartosz Rybaczyk NBP Working Paper No. 241 Fan chart – a tool for NBP’s monetary policy making Paweł Pońsko, Bartosz Rybaczyk Economic Institute Warsaw, 2016 Paweł Pońsko – Economic Institute, NBP and Warsaw School of Economics; [email protected] Bartosz Rybaczyk – Economic Institute, NBP; [email protected] Published by: Narodowy Bank Polski Education & Publishing Department ul. Świętokrzyska 11/21 00-919 Warszawa, Poland phone +48 22 185 23 35 www.nbp.pl ISSN 2084-624X © Copyright Narodowy Bank Polski, 2016 Contents Introduction 5 The process 9 The choice of probability distribution 11 The central path of projection 14 Prediction uncertainty 15 Prediction asymmetry 17 Probability intervals 18 Yearly data 20 The fan chart procedure 21 An illustration 23 10.1 Scaling Factors 25 10.2 Ex-post forecasting errors of the endogenous variables 25 10.3 Corrected exogenous errors 26 10.4 Pure forecasting error 26 10.5 The asymmetry of the fan chart 27 Fan chart decomposition 30 References 32 Appendix A. The two-piece normal distribution and its properties 34 Appendix B. Determining the triple 36 Appendix C. Highest probability density regions 37 Appendix D. Variance estimations 38 NBP Working Paper No. 241 3 Abstract Abstract Introduction In this note we describe, in substantial detail, the methodology behind the Narodowy Bank Polski (NBP) is, by its mandate, an inflation-targeting central construction of NBP’s fan chart. This note is meant to help the readers interpret bank. However, monetary policy decisions rest on the shoulders of the Monetary information contained in the mid-term projection, understand the differences in the Policy Council (MPC) members, who make up an independent body of experts.1 predicted uncertainty between the projection rounds, and the usefulness of the Hence, the NBP staff role is to support the MPC with expertise without influencing projection for the monetary policy conduct. -
The Nobel Foundation Annual Review 2018
THE NOBEL FOUNDATION ANNUAL REVIEW • 2018 THE NOBEL FOUNDATION · ANNUAL REVIEW 2018 1 For the greatest beneft to humankind ALFRED NOBEL 2 THE NOBEL FOUNDATION · ANNUAL REVIEW 2018 “I can tell you how. It is very easy. The first thing you must do is to have great teachers.” Paul A. Samuelson, 1970 Laureate in Economic Sciences, on how to earn a Nobel Prize. obel Laureates often Luther King, Jr., and with a Nobel Prize attest to how crucial Teacher Summit on the theme Teach their teachers have been. Love and Understanding, with 350 Teachers, researchers and teachers from 15 countries attending. others who contribute Al Gore, the 2007 Peace Prize Lars Heikensten, Executive Director Nto increased knowledge are the heroes Laureate, addressed How to Solve the of the Nobel Foundation since 2011. and heroines of our age. When the very Climate Crisis when he spoke at the 2018 Photo: Kari Kohvakka idea of science is being questioned, our Nobel Peace Prize Forum in Oslo. During school systems are being allowed to the coming year, many of our outreach decay, children are even being prevented activities will focus on the climate crisis. from attending school and many people It will be a central issue at both the are still being denied fundamental hu- Nobel Week Dialogue in Gothenburg and man rights, the forces of open, tolerant the Nobel Prize Teacher Summit in and democratic societies need to defend Stockholm. We are also planning a major education, research and enlightenment – conference on the climate change issue proactively and passionately. in Washington D.C. -
Chi-Squared Tests of Interval and Density Forecasts, and the Bank of England’S Fan Charts
EUROPEAN CENTRAL BANK WORKING PAPER SERIES ECB EZB EKT BCE EKP WORKING PAPER NO. 83 CHI-SQUARED TESTS OF INTERVAL AND DENSITY FORECASTS, AND THE BANK OF ENGLAND’S FAN CHARTS BY KENNETH F. WALLIS November 2001 EUROPEAN CENTRAL BANK WORKING PAPER SERIES WORKING PAPER NO. 83 CHI-SQUARED TESTS OF INTERVAL AND DENSITY FORECASTS, AND THE BANK OF ENGLAND’S FAN CHARTS BY KENNETH F. WALLIS* November 2001 * Acknowledgement The first version of this paper was written during a period of study leave granted by the University of Warwick and spent at the Economic Research Department, Reserve Bank of Australia and the Economics Program RSSS, Australian National University; the support of these institutions is gratefully acknowledged. This paper has been presented at the ECB workshop on ‘Forecasting Techniques’, September 2001. © European Central Bank, 2001 Address Kaiserstrasse 29 D-60311 Frankfurt am Main Germany Postal address Postfach 16 03 19 D-60066 Frankfurt am Main Germany Telephone +49 69 1344 0 Internet http://www.ecb.int Fax +49 69 1344 6000 Telex 411 144 ecb d All rights reserved. Reproduction for educational and non-commercial purposes is permitted provided that the source is acknowledged. The views expressed in this paper are those of the authors and do not necessarily reflect those of the European Central Bank. ISSN 1561-0810 Contents Abstract 4 1 Introduction 5 2 Unconditional coverage and goodness-of-fit tests 8 3 Tests of independence 10 4 Joint tests of coverage and independence 14 5 Bank of England fan chart forecasts 15 6 Conclusion 19 References 21 Tables and Figures 22 European Central Bank Working Paper Series 27 ECB • Working Paper No 83 • November 2001 3 Abstract This paper reviews recently proposed likelihood ratio tests of goodness-of-fit and independence of interval forecasts. -
Economic Review 2007:1
Q The role of academics in monetary policy: a study of Swedish infl ation targeting1 MIKAEL APEL, LARS HEIKENSTEN AND PER JANSSON Mikael Apel works in the Monetary Policy Department at Sveriges Riksbank, the central bank of Sweden. Lars Heikensten is Sweden’s member of the European Court of Auditors and a former Governor of the Riksbank. Per Jansson is State Secretary at the Ministry of Finance and a former deputy director of the Riksbank’s Monetary Policy Department. The way in which monetary policy is conducted has changed consider- ably in recent decades. The process can be divided into two phases. The fi rst involved changes in the general formation of policy (a change of regime), whereby low and stable infl ation was given higher prior- ity than before and central banks were made more independent. The second phase involves changes that in various respects have resulted in further developments of the new regime. Starting from experience of the Swedis h infl ation-targeting regime, this article describes the role aca- demic research has played for the way in which monetary policy is cur- rently formed. The article also presents a picture of the interplay between researchers and practitioners in the course of this process of change. 1. Introduction In general terms, monetary policy can be said to be represented by a central bank’s instrumental-rate decisions with a view to infl uencing aggregate demand and the rate of price increases in the economy. The way in which monetary policy is conducted has changed considerably in recent decades. -
Fanplot: Visualisation of Sequential Probability Distributions Using Fan Charts
Package ‘fanplot’ August 2, 2021 Type Package Title Visualisation of Sequential Probability Distributions Using Fan Charts Version 4.0.0 Maintainer Guy J. Abel <[email protected]> Description Visualise sequential distributions using a range of plotting styles. Sequential distribution data can be input as either simulations or values corresponding to percentiles over time. Plots are added to existing graphic devices using the fan function. Users can choose from four different styles, including fan chart type plots, where a set of coloured polygon, with shadings corresponding to the percentile values are layered to represent different uncertainty levels. Full details in R Journal arti- cle; Abel (2015) <doi:10.32614/RJ-2015-002>. License GPL-2 URL http://guyabel.github.io/fanplot/ BugReports https://github.com/guyabel/fanplot/issues/ Imports methods Depends R (>= 2.10) Suggests shiny LazyData true NeedsCompilation no Author Guy J. Abel [aut, cre] (<https://orcid.org/0000-0002-4893-5687>) Repository CRAN Date/Publication 2021-08-02 09:20:02 UTC R topics documented: fanplot-package . .2 boe..............................................2 cpi..............................................5 1 2 boe dsplitnorm . .5 fan..............................................8 ips.............................................. 13 svpdx . 14 th.mcmc . 15 Index 17 fanplot-package Visualisation of Sequential Probability Distributions Using Fan Charts. Description Visualise sequential distributions using a range of plotting styles. Sequential distribution data can be input as either simulations or values corresponding to percentiles over time. Plots are added to existing graphic devices using the fan function. Users can choose from four different styles, including fan chart type plots, where a set of coloured polygon, with shadings corresponding to the percentile values are layered to represent different uncertainty levels. -
Visualizing Financial Futures
Visualizing Financial Futures SUSANNA HEYMAN DOCTORAL THESIS NO. 17. 2017 KTH ROYAL INSTITUTE OF TECHNOLOGY SCHOOL OF COMPUTER SCIENCE AND COMMUNICATION DEPT. OF MEDIA TECHNOLOGY AND INTERACTION DESIGN SE-100 44 STOCKHOLM, SWEDEN TRITA-CSC-A-2017:17 ISSN-1653-5723 ISRN KTH/CSC/A--17/17-SE ISBN 978-91-7729-471-9 AKADEMISK AVHANDLING SOM MED TILLSTÅND AV KTH I STOCKHOLM FRAMLÄGGES TILL OFFENTLIG GRANSKNING FÖR AVLÄGGANDE AV TEKNISK DOKTORSEXAMEN FREDAGEN DEN 8 SEPTEMBER 2017 KL. 13:00 I SAL F3, KTH, LINDSTEDTSVÄGEN 26, STOCKHOLM. Abstract Research on financial decision aids, systems designed to help people make financial decisions, is sparse. Previous research has often focused on the theoretical soundness of the advice that the systems provide. The original contribution of this doctoral thesis is a set of empirical studies of how non-expert people understand the advice provided by financial decision aids. Since every piece of advice must be interpreted by a receiver, the accuracy of the advice can be corrupted along the way if the receiver does not understand complicated terminology, probabilistic reasoning, or abstract concepts. The design concept resulting from the studies visualizes a unique combination of short-term and long-term variables that are usually treated as separate and not interacting with each other; loans and amortizations, insurance, retirement saving, and consumption. The aim is to visualize the consequences of different decisions and possible adverse events in terms of their effect on the user’s future consumption, rather than abstract numbers detached from the user’s lived experience. The design concept was tested and evaluated by personal finance experts and professional financial advisors, as well as students and people without financial education, who represented the target users of the system. -
Candidature of Mr Lars HEIKENSTEN
COUNCIL OF Brussels, 5 October 2005 THE EUROPEAN UNION 12995/05 INST 70 CMPT 6 COVER NOTE from: Ms Ingrid HJELT af TROLLE, Chargé d'affaires a. i. Permanent Representation of Sweden to the European Union date of receipt: 5 October 2005 to: Council Secretariat Subject: Partial renewal of members of the Court of Auditors - Candidature of Mr Lars HEIKENSTEN With reference to your letter to Mr Sven-Olof Petersson, Permanent Representative of Sweden to the European Union, dated 18 July 2005, regarding the appointment of the Swedish Member of the European Court of Auditors as of 1 March 2006, I am pleased to inform you that the Swedish government wishes to nominate Mr Lars Heikensten for the next six year term. Please find enclosed Mr Heikensten's curriculum vitae. (Complimentary close). (s.) Ingrid HJELT af TROLLE ____________ 12995/05 EP 1 JUR EN ANNEX CURRICULUM VITAE Lars HEIKENSTEN, Governor, Sveriges Riksbank Born 13 September 1950 in Stockholm, Sweden Education American High School (Marion High School, Iowa) 1969 Swedish High School (Bromma Gymnasium) 1970 M.B.A. (Stockholm School of Economics) 1974 Doctor of Economics (Stockholm School of Economics) 1984 Positions Researcher and teacher in economics at the Stockholm School of Economics. Fields of research: Development Economics, Structural Change and Labour Market Economics 1972-1984 Chief Economist at the National Debt Office 1984-1985 Assistant Under-Secretary, Ministry of Finance (Head of Division for Medium and Long-Term Economic Policy Issues) 1985-1990 Under-Secretary for Economic -
Annual Report 2001
Sveriges Riksbank A R Contents INTRODUCTION SVERIGES RIKSBANK 2 2001 IN BRIEF 3 STATEMENT BY THE GOVERNOR 4 OPERATIONS 2001 MONETARY POLICY 7 FINANCIAL STABILITY 13 INTERNATIONAL CO-OPERATION 16 STATISTICS 18 RESEARCH 19 THE RIKSBANK’S SUBSIDIARIES 20 THE RIKSBANK’S PRIZE IN ECONOMIC SCIENCES 22 SUBMISSIONS 23 HOW THE RIKSBANK WORKS THE MONETARY POLICY PROCESS 25 THE ANALYSIS OF FINANCIAL STABILITY 29 MANAGEMENT AND ORGANISATION ORGANISATION 32 THE EXECUTIVE BOARD 34 EMPLOYEES 36 IMPORTANT DATES 2002 Executive Board monetary policy meeting 7 February THE GENERAL COUNCIL 38 Executive Board monetary policy meeting 18 March Inflation Report no. 1 published 19 March ANNUAL ACCOUNTS The Governor attends the Riksdag Finance Committee hearing 19 March Executive Board monetary policy meeting 25 April DIRECTORS’ REPORT 40 Executive Board monetary policy meeting 5 June Inflation Report no. 2 published 6 June ACCOUNTING PRINCIPLES 43 Executive Board monetary policy meeting 4 July Executive Board monetary policy meeting 15 August BALANCE SHEET 44 The dates for the monetary policy meetings in the autumn have not yet been con- PROFIT AND LOSS ACCOUNT 45 firmed. Information on monetary policy decisions is usually published on the day following a monetary policy meeting. NOTES 46 THIS YEAR’S PHOTOGRAPHIC THEME FIVE-YEAR OVERVIEW 50 Sveriges Riksbank is a knowledge organisation and the bank aims to achieve a learning climate that stimulates and develops employees. Employees can acquire SUBSIDIARIES 51 knowledge both through training and in working together with colleagues and ex- ternal contacts. The Riksbank’s independent position requires openness with re- ALLOCATION OF PROFITS 53 gard to the motives behind its decisions. -
Prediction Intervals for Macroeconomic Variables Based on Uncertainty Measures
Prediction Intervals for Macroeconomic Variables Based on Uncertainty Measures Pei-Hua (Peggy) Hsieh ANR: 591577 Academic supervisor: Prof. Dr. Bertrand Melenberg Second reader: Prof. Dr. Pavel Ciˇzekˇ Internship supervisor: Dr. Adam Elbourne A thesis submitted in partial fulfillment of the requirements for the degree: Master of Science in Econometrics and Mathematical Economics Tilburg School of Economics and Management Tilburg University The Netherlands Date: September 26, 2016 Prediction Intervals for Macroeconomic Variables Based on Uncertainty Measures Pei-Hua (Peggy) Hsieh ∗ October 7, 2016 Abstract This paper develops a method for incorporating uncertainty measures into the formation of confidence intervals around predictions of macroeconomic variables. These intervals are used for plotting fan charts, a graphical rep- resentation of forecasts pioneered by the Bank of England, which is commonly employed by central banks. I demonstrate and evaluate the proposed method by using it to plot fan charts for real GDP growth rate in the Netherlands. This paper aims to provide concrete recommendations for the Centraal Planbureau (CPB). ∗I am indebted to Prof. Dr. Bertrand Melenberg for his inspiring guidance and support. I would also like to thank my supervisor from the CPB Dr. Adam Elbourne for providing me with data and helpful comments. Finally, I thank my family, instructors at Tilburg university and colleagues from the CPB. 1 Contents 1 Introduction6 2 Methodology 10 2.1 Step 1................................... 11 2.2 Step 2................................... 12 2.3 Step 3................................... 15 3 Data description 16 4 Summary Statistics 19 4.1 Dependent Variable............................ 19 4.2 Explanatory Variables.......................... 23 5 Empirical results 24 5.1 Short dataset: using data from Consensus Economics........ -
Quantifying Uncertainties in Global Growth Forecasts
WPS7770 Policy Research Working Paper 7770 Public Disclosure Authorized Quantifying Uncertainties in Global Growth Forecasts Public Disclosure Authorized Franziska L. Ohnsorge Marc Stocker Modeste Y. Some Public Disclosure Authorized Public Disclosure Authorized Development Economics Development Prospects Group July 2016 Policy Research Working Paper 7770 Abstract This paper presents a procedure to construct an asym- growth. The weights are estimated using a vector autoregres- metric fan chart of risks around global growth forecasts. sion analysis. The empirical estimates indicate that forecast The distribution of risks around global growth forecasts is uncertainty has increased since January 2016, while the estimated by weighting information extracted from option balance of risks to global growth has tilted to the downside. pricing and survey-based measures of risk factors of global This paper is a product of the Development Prospects Group, Development Economics. It is part of a larger effort by the World Bank to provide open access to its research and make a contribution to development policy discussions around the world. Policy Research Working Papers are also posted on the Web at http://econ.worldbank.org. The authors may be contacted at [email protected]. The Policy Research Working Paper Series disseminates the findings of work in progress to encourage the exchange of ideas about development issues. An objective of the series is to get the findings out quickly, even if the presentations are less than fully polished. The papers carry the names of the authors and should be cited accordingly. The findings, interpretations, and conclusions expressed in this paper are entirely those of the authors. -
Racing Horses:Constructingand Evaluating Forecastsin 1 Political Science
RACING HORSES:CONSTRUCTING AND EVALUATING FORECASTS IN 1 POLITICAL SCIENCE Patrick T. Brandt Associate Professor School of Economic, Political, and Policy Science, University of Texas, Dallas 800 W. Campbell Road, GR31, Dallas, TX 75080-3021 Phone: 972-883-4923, Fax: 972-883-6297, Email: [email protected] John R. Freeman Professor Department of Political Science, University of Minnesota 1414 Social Sciences Bldg; 267 19th Ave. South; Mpls, MN 55455 Phone: 612-624-6018, Fax: 612-624-7599, Email: [email protected] Philip A. Schrodt Professor Department of Political Science, Pennsylvania State University 227 Pond Laboratory, University Park, PA 16802-6200 Phone: 814-863-8978, Fax: 814-863-8979, Email: [email protected] 1Paper presented at the 28th Summer Meeting of the Society for Political Methodology, Princeton University, July 2011. This research is supported by the National Science Foundation, award numbers SES 0921051, SES 0921018, and SES 1004414. We thank Michael D. Ward for comments. The authors are responsible for the paper's contents. Brandt, Freeman & Schrodt Racing Horses 1 Introduction In recent years, political forecasting has become a more common exercise. These forecasts range from predictions of election outcomes (Campbell 2000, 2010a) to forecasts of political insta- bility (O’Brien 2010, Goldstone, et al. 2010). They are intended to aid campaign managers, political observers, policy makers. The analysts who produce them often compare, either implicitly or ex- plicitly, the performance of their forecasting models to that of competing models. If the model is successful, they declare it the winner, as if their horse had beaten its competitors in a race.1 Meanwhile, scholars in disciplines as diverse as statistics, meteorology and finance are con- ducting formal forecasting competitions.