Idaho State UNIVERSITY Office of the President 921 South 8th Avenue, Stop 8310 * Pocatello, Idaho 83209-8310

February 27, 2015

Kevin M. Ramsey Senior Project Manager Fuel Manufacturing Branch - NRC Mail Stop E2-CHOM 11555 Rockville Pike Rockville, MD 20852-2738

Dear Mr. Ramsey,

Idaho State University has two personnel changes, the appointments for which were just recently made. Dr. Cornelis Van der Schyf has been appointed as the new Vice President for Research and Dr. Mary Lou Dunzik-Gougar has been appointed as both the new Chair of Nuclear Engineering and Health Physics as well as the new administrator of NRC license SNM-1373.

Dr. Van der Schyf has over 13 years of administrative and supervisory experience including: Head of the Department of Pharmaceutical Chemistry at Potchefstroom University for 5 years, holding administrative roles at Northeast Ohio Medical University that included Chair of the Department of Pharmaceutical Sciences, Graduate Studies Program Director and Associate Dean for Research and Graduate Studies for a combined 7 years, and Dean of the Graduate School at Idaho State University.

Dr. Dunzik-Gougar's experience includes:

- A PhD in Nuclear Engineering from Penn State University, which included courses in reactor theory and experiments, - Over 10 years experience teaching various aspects of nuclear engineering in the U.S. and South Africa, - ABET Certification as an evaluator of nuclear and radiological engineering programs for U.S. and international universities (having visited reactor facilities at 6 U.S. universities to date) and - 20 years experience working with radioactive material and/or in radiation environment,

Enclosed are the revisions to Attachment I (Roster of University Officials) and the curriculum vitae for Drs Van der Schyf and Dunzik-Gougar

We hope that these personnel changes will be satisfactory for your expectations.

Sincerely,

Arthur C. Vailas, Ph.D. President • , 0• ( Phone: (208) 282-3440 e Fax: (208) 282-4487 * www.isu.edu/president ISU is an Equal Opportunity Employer ATTACHMENT 1 - February 27, 2015 Roster of University Officials and Nuclear Personnel Responsible for Materials License SNM-1373, Docket No. 1374

President of the University Dr. Arthur C. Vailas 264 Administration Building, Stop 8310 Idaho State University Pocatello, ID 83209-8310 Tel: (208) 282-3440 Fax: (208) 282-4487 Email: [email protected]

Vice President for Research and Dean of Graduate Studies Dr. Cornelis Van Der Schyf 248 Administration Building, Stop 8130 Idaho State University Pocatello, ID 83209-8130 Tel: (208) 282-3134 Fax: (208) 282-4487 Email: [email protected]

Vice President for Finance and Administration Dr. James Fletcher 237 Administration Building, Stop 8219 Idaho State University Pocatello, ID 83209-8219 Tel: (208) 282-3540 Fax: (208) 282-4725 Email: [email protected]

Dean of the College of Science and Engineering Dr. Richard Brey Colonial Hall, Stop 8065 Idaho State University Pocatello, ID 83209-8065 Tel: (208) 282-3099 Fax: (208) 282-4464 Email: [email protected]

Radiation Safety Officer and Technical Safety Director Peter Farina Physical Science Building, Stop 8103 Idaho State University Pocatello, ID 83209-8103 Tel: (208) 282-3627 Fax: (208) 282-4646 Email: [email protected]

ISU Personnel Roster Page 1/2 Revised 2/27/15 Chair of Nuclear Engineering & Health Physics Dr. Mary Lou Dunzik-Gougar Center for Advanced Energy Studies 921 S 8th Ave Stop 8150 Pocatello, ID 83209 Tel: (208) 533-8111 Tel: (208) 282-2902 Email: [email protected]

License Administrator Dr. Mary Lou Dunzik-Gougar Center for Advanced Energy Studies 921 S 8th Ave Stop 8150 Pocatello, ID 83209 Tel: (208) 533-8111 Tel: (208) 282-2902 Email: [email protected]

Reactor Supervisor Adam Mallicoat Lillibridge Engineering laboratory, Stop 8060 Idaho State University Pocatello, ID 83209-8060 Tel: (208) 282-4237 Fax: (208) 282-4538 Email: [email protected]

ISU Personnel Roster Page 2/2 Revised 2/27/15 Mary Lou Dunzik-Gougar, PhD

Idaho State University, Center for Advanced Energy Studies, University Blvd, Idaho Falls, ID 83402 Phone: 208-533-8111 Cell: 208-569-9915 Email: [email protected]

EDUCATION Doctor of Philosophy Degree (2003) in Nuclear Engineering with a specialization in the nuclear fuel cycle, from Pennsylvania State University: "Fission Product Ion Exchange between Zeolite and a Molten Salt." Master of Science Degree (1997) in the Environmental Pollution Control (inter-college) Program with specialization in radioactive waste management from Pennsylvania State University: "A Vitrifiable Cement Waste Form for Disposal of Spent Nuclear Fuel Reprocessing Waste." Bachelor of Science Degree (1987) in Chemistry from Cedar Crest College, Allentown, PA, GPA: 3.7

WORK EXPERIENCE Idaho State University Acting Chair of Nuclear Engineering and Health Physics Program (March 2014 to present) Associate Chair (December 2012 to March 2014), Tenured Associate Professor (May 2012 to present), Assistant Professor (March 2004 to May 2012) * Responsiblefor curriculum development and assessment. course scheduling, nuclear engineering scholarships * PI or Co-PIfor - $2. 7 million (2004-presentcumulative) in grants and contracts (roughly 2/3 research and 1/3 student support) " Research advisorfor 20 MS theses and 8 PhD dissertations (2004-present) " Co-Developer and Directorof -2+2 Nuclear Engineering Scholarship Program"for engineeringstudents at ID research universities: responsibilit for undergradand gradprograms growth and development via recruiting and collaborationwith INL and universities (2004 - 2009) * Co-chairIdaho Organizing Coinmitteefor thefirst World Nuclear University Summer Institute (July-A ugust. 2005) conductedjointlv by World Nuclear Association and US Dept. of Energy (2004-2005) " Director of the Applied Nuclear Energy Certificate Program (2004 - 2006)

Idaho National Laboratory Affiliate Staff Scientist (2005 to present) * P1for Lab Directed Research and Development Project SINEMA (Simulation Institute for Nuclear Enterprise Modeling and AnalYsis), with associatedmanagement responsibilityfor 4 INL researchersand project annual budget ($500,000), including subcontracts with 5 universities (ISU, MIT. NC State, University of Cincinnatiand University of Wisconsin-Madison). Guided and coordinated research, conducted semi- annual review meetings and contributed to DOE's Advanced Fuel Cycle Initiative Program activities (2005- 2007) " P1for project to characterizenuclear grade graphite with emphasis on characterizationof 14 C in irradiated graphite and development of 11C removal method for graphite re-use or safer disposal. (In conjunction with the Graphite Technology group of the Next Generation Nuclear Plantproject of DOE and supportedby NEUP grant award "Removal of 14C from irradiatedgraphite for graphite recycle and waste volume reduction. ') (2009 to 2013) * P1lfor experimentalprojectto study' migration of veiy low concentrationfission products in nuclear graphite to aid in modeling next generation gas-cooled reactors (2013-present) " Pifor project to analyze TRISO particle SiC layer characterizationdata to determine the relationships between SiC laver strength, grain characterand the production parameters (laver deposition timne. temperature and tool) and to report results of analyses in technicaljournal papers or INL reports.

IAEA Coordinated Research Proiect U.S. Representative (2011-2014) * Invited to serve as U.S. representative in CRP entitled "Treatment of Irradiated Graphite to Meet Acceptance Criteria for Waste Disposal" llectrcitc de France (EDF) Consultant (November 2012 to present) * Consultant to EDF via internationalcontract with S.A. Technology for irradiatedgraphite treatment and disposal.

PBMR Ltd. Pty. / University of Pretoria. Republic of South Africa On leave of absence from ISU and INL (January 2008 to March 2009) Senior Consultant / Visiting Research Professor * Joint appointment between PBMR and the University of Pretoria(Chemical EngineeringDepartment). Project Lead and Plfor PBMR's (Graphite) Waste Minimization Project,research component conducted at UP. Assessed problem, developed experimental plan. outfitted lab and coordinated 7 researchers(2 interns, 4 graduatestudents and I post-doe) " Represented PBMR in CARBOWASTE Program (Treatment and Disposal of IrradiatedGraphite and Other Carbonaceous Waste) under EC's 7Th Framework Programme (presentationsat meetings in Jfilich, Germany (5/08), Lyon, France (10/08) and Berlin, (1/09)) " Advised 2 MSc theses and developed/taught coursefor North-West University, South Africa " Continuing consultation (March 2009 to 2012)

Argonne National Laboratory-West / Pennsylvania State University Nuclear Engineering Specialist / Graduate Fellow ( 1994 - 2003) * PartANL employee ('98-'03) and part PSU graduatefellow. Responsiblefor various research tasks supporting the Spent Fuel Treatment Demonstrationprogram and for PhD dissertation.

Pennsylvania State University / Philadelphia Electric Company Technology Education Specialist (1992-1993) * Employed by Penn State Nuclear Engineering Program. which was contracted by PhiladelphiaElectric Co., to perform educational outreach in communities served hby its nuclearpower plants near Pottstown (Limerick) and Delta (Peach Bottom). PA. Developed and presentedprograms on nuclear energy topicsfor various community and professional groups.

Charles Co. School Dist. (MD)/TASIS England American School (UK)/Council Rock High School (PA) Secondary School Science and Mathematics Teacher (1987-1992, 1993-1994) * Positions with each school requiredteaching assigned classes in science (chemistry, p/tvsics and physical science) and mathematics (algebraand consumer math). Additional responsibilitiesat TASIS included non- teaching duties with the boardingstudents.

TEACHING and ADVISING ISU courses developed and/or taught * Introduction to Practical Nuclear Engineering (NSEN 615) Basic concepts of radiation,nuclear and reactor physics. and nuclear plant designs for Certificate (non-engineering)Program (Taught Fall 2004) * Introduction to Nuclear Engineering (NE 402/502) Basic nuclear/atomicprocesses, radioactivedecav binding energy, radiationinteractions, reaction cross-sections, neutron diffusion and radiation sources for undergrad nuclear engineering students and graduate students comingfrom non-nuclear engineering undergrad(Taught Fall 2005, 2006, 2007, 2009, 2010 in conjunction with U of Idaho on 3 campuses) * Radioactive Waste Management (N SEN 618) Designed this new graduatelevel course, which addresses technical and non-technical aspects of radioactive waste management associated with each step of the nuclearfiel cycle (Taught Fall 2009, 2010, 201 1, 2012, 2013) * Materials Aspects of Radionuclide Immobilization (NSEN 619) Designed this new graduate level course, which addresses materialschemiistrv and fabrication of waste glasses, ceramnics and cements: waste form development and characterization:waste form degradation,radionuclide release and migration (Taught spring 2010, 2011, 2012, 2013 in conjunction with UNLV on 3 campuses) * College of Engineering graduate student seminar (ENGR 651) Organized nuclearprofessional speakers (Fall semesters 2004 - 2007) * Introduction to Nuclear Engineering (N E 120) Designed thisfreshman level course to introduce thefield and basic concepts of nuclear engineering (Taught fall and spring 2013 and spring 2014) * Nuclear Engineering I and I1 (NE 301 and 302) Designed these sophomore-juniorlevel courses to replace NE 402 in undergradcurriculum addressingnuclear stability and radioactivedecay: types and energies of nuclear reactions: interactions of radiationwith matter, including cross sections, attenuation,and scattering: basics of controlled chain reactions and the design of nuclear power reactors. Fission reactor theor,, including neutron moderation. criticality, neutron life cycle and neutron diffusion. Types of reactors,present andfuture (Taught 2011 -2014) * Nuclear Fuel Cycle Systems (NE 446/546) Uranium mining, milling, conversion: nuclear enrichment technology including cascade analysis; fuiel fibrication, criticality safety in the nuclearfuel cycle, introduction to ORIGEN and Monte-Carlo methods and codes, reactorfuel management, waste management (LL W, HL W. TR U waste) (Teaching for the first time Spring 2015)

Other courses/workshops developed and/or taup-ht " "Nuclear Engineering I," (NUCI 511) (June-July 2009, for North-West University, at Koeberg Nuclear Power Station, Cape Town, South Africa) Contracted to develop course materials for online and face-to-face components of course and teach course. " "Nonproilferation Instrumentation and Measurements Course," Co-organizer of this Western Nuclear Science Alliance (WNSA) course, (July 26-30, 2004 at Idaho National Eng. Lab and Argonne National Lab-West) (Spring- Summer 2004). * "Introduction to Nuclear Engineering," informal lectures for research group (February-March, 2009, University of Pretoria, South Africa)

ISU Academic Advising * Advisor and MS thesis defense committee chair -"EBSDDetermined Grain and Grain Boundary Characteristic Correlation with Deposition and Annealing Temperatures of the CVD coated SiC Layer of TRISO Particle Nuclear Fuel," MS in Nuclear Science and Engineering, Connie Mae Siepker Hill (2014) "Optimization of the Thermal Treatment Process for the Removal of 14C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle," MS in Nuclear Science and Engineering, Katherine Jeanne Nelson (2014) "The Next Step in the Evolution of the Nuclear Thermal Rocket," Lucas T. Fischbaber, MS in Nuclear Science and Engineering (2013) "Removal of 14C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment," MS in Nuclear Science and Engineering, Tara E. Smith (2012) 4 "Characterizing the Pathway to Formation of 1 C in Irradiated Graphite," MS in Nuclear Science and Engineering, Shilo McCrory (2011) "Removal of Carbon-14 from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment," MS in Nuclear Science and Engineering, James Cleaver (2011) "Testing of Small Graphite Samples for Nuclear Qualification," MS in Nuclear Science and Engineering, Julie A. Chapman (2010) (co-advisor with Dr. William Windes) 'T'ritium Migration through a High Temperature Gas-Cooled Reactor," Russell Jones (2009) (co-advisor with Dr. Michael Lineberry) "Modeling of Pebble Bed Reactor Transients using Explicit Coupling of the PEBBED Neutronics Code and RELAP5-3D Thermal Hydraulics Code," Michael K. Oliver, MS in Nuclear Science and Engineering (2008) - "Microstructure Examination to Aid in Understanding Friction Bonding Fabrication Technique for Monolithic Nuclear Fuel," Karen L. Shropshire (2008) - "Development of the Global Evaluation of Nuclear Infrastructure and Utilization Scenarios (GENIUS) Nuclear Fuel Cycle Systems Analysis Code," Christopher A. Juchau (2008) - "Modeling Zeolite Adsorption of Salt Species Encountered in Spent Nuclear Fuel Pyroprocessing," Philip L. Tufts (2007) - "Online Monitoring of Actinide Concentrations in Molten Salt Electrolyte," Curtis W. Johnson (2007) - "Qualification Plan of Spent Triso Fuel for Permanent Repository Disposal," Joshua L. Peterson (2006) - "Assessment of Available Fast Neutron Irradiation Facilities and the Validation of Plate 2.0 to Support the Conceptual Design of a Gas Test Loop in the Advanced Test Reactor," William J. Skerjanc (2005) (Co-Advisor with Dr. John Bennion)

* Advisor and PhD dissertation defense committee chair 4 - "Characterization of I C in Neutron-Irradiated Graphite," Daniel Patrick LaBrier, PhD in Nuclear Science and Engineering (2013) - "Pebble bed pebble motion: Simulation and Applications," Joshua J. Cogliati, PhD in Applied Science and Engineering (2010) (co-advisor with Dr. Abderaffi Ougouag) - "An Earthquake Transient Method for Pebble-Bed Reactors and a Fuel Temperature Model for TRISO Fuel Reactors," Javier Ortensi, PhD in Applied Science and Engineering (2009) (co-advisor with Dr. Abderaffi Ougouag)

* Thesis/dissertation committee member - "Fission Yield Measurements as a Function of Incident Neutron Energy Using a Time Projection Chamber," Verena Kleinrath, PhD in Nuclear Science and Engineering proposal defense, October 2012 - "Investigation of a Real-time Broad Electron Beam Imaging and Dosimetry System Using a Faraday Cup Array," Nicholas Altic, MS in Health Physics (2011) "The Performance of Thick Gaseous Electron Multiplier Preamplifiers (THGEM) as a Neutron Sensitive Detector," Haitham Abdel Majid, PhD in Physics proposal defense, 25 May 2011 - "A Test of Accelerator-Based Positron Annihilation Spectroscopy Techniques to Measure Defects in Composite Materials," Kristen Smith, MS in Health Physics (2007) - MBA student (2007) * Advisor of approximately 50 (per year) nuclear engineering undergraduate students. Other Academic Advisinig * Advisor and MSc committee chair 4 - "Characterization of Microbial Survival in the Presence of Radioactive 1 C Spiked Salts in Order to Minimize Graphite Waste Produced in Graphite Moderated Nuclear Reactors," Gopolang Ashy Pete, MSc Applied Radiation Science and Technology, North-West University, South Africa (pending) - 'Timed Sampling Experimental Process to Assess Carbon-14 Consumption by Microbes," Itumeleng I. Mashifane, MSc Applied Radiation Science and Technology, North-West University, South Africa (May 2011)

PROFESSIONAL DEVELOPMENT and SERVICE ABET Trained evaluator for university nuclear science and engineering programs - ABET Program Evaluator (PEV) training - Baltimore, MD (May 2010) - Evaluation visit to Texas A&M University (September 2010) - Evaluation visit to Renssalaer Polytechnic Institute (November 2013) - Evaluation visit to Georgia Technical Institute (September 2014) International Safeguards Pre-inspector Course (13-22 May 2014) Completed course, which is sponsored by the Nuclear Safeguards and Security group of the National Nuclear Security Administration American Nuclear Society (ANS) NationalANS (member 1992 to present) Outreach for ANS: Congressional Seminar Series and Capitol Hill workshop presenter (2012 to present) 7 to date Teacher Workshop co-organizer and presenter (2001 to present) More than 30 workshops to date Media interviews on various topics (2000 to present) More than 40 to date Committee appointments: Communications, formerly Public Information (Chair 2013-2015, Vice-Chair 2011-2013, member I 999-present), Nominating Committee (2006 and 2014), Professional Women in ANS (1997-2000, 2006-2012), Accreditation Policies and Procedures (Vice-Chair 2011-2013, 2006 to present), Special Selection Committee for Nominating Committee (2011), Student Sections (1999-2009), Planning (1997-2000) Fuel Cycle and Waste Management Division governance: *Executive Board (2013-2016 and 2006-2008), Secretary/Treasurer and Chair of Nominating Committee (2012- 2013), Chair (2011-2012), Vice Chair (2010-2011), Secretary/Treasurer (2009-2010), Technical Program Chair (2008-2009) Technical meeting organization: Student Program Chair for Annual Meeting (2006), Student Program Chair and Teachers' Workshop organizer for International Joint Topical Meeting: "Sharing Solutions for Emergencies and Hazardous Environment" (2006), Co- organizer for Professional Development Workshop for students and young professionals in ANS at Winter Meeting (2004), Organizing Committee Chair for DOE Spent Nuclear Fuel and Fissile Material Management Topical Meeting (2000), Co- organizer of Student Mini-Conference at ANS Winter meeting (2001), Organizing Committee for Global 99 Topical Meeting (1999), Co-organizer and presenter for "Survival Skills for the Workplace" workshop sponsored by PWANS, ANS Annual meeting (1997). Technical session organizer and/or chair (for ANS national meeting unless otherwise specified): "University Program Accreditation 101 - Panel" (November 2013); "Fuel Cycle and Waste Management - II" (June 2012); "Nuclear Graphite Developments for the Beginning and End of the Fuel Cycle" and "Nonproliferation and Radwaste Management Education at University" (November 201 1); "Modeling of Nuclear Fuel Cycles" (June 2009); "Fuel Cycle and Waste Management - I, II, Ill, IV" (November 2008); "Recent Developments in Fuel Cycle Modeling and Systems Analysis - I & II" (November 2007); "Systems Analysis or Strategic Implications of Integrated Fuel Cycle Concepts" (September 2007, Global 2007 Topical Meeting); "Computational Methods for Fuel Cycle Simulations" and "Closing the Fuel Cycle" (June 2007); "Focus on Communications - III: What Can We Learn from the Students?" and "Recent Development in Fuel Cycle Modeling and Systems Analysis - I & I1" (November 2006); "Engaging the Anti's: Communications with Environmental Groups" and "'Too Cheap to Meter' and Other Myths of the Nuclear Age" (June 2005) Board of Directors (1996-1999) Including Capitol Hill visit 1999 Idaho Local ProfessionalSection (member 1998 - present) Treasurer (99-00); Education Committee (99-2007). Organized and ran workshops for Boy Scout badge and Girl Scout Patch on nuclear topics, Performed pilot use of Nuclear Technology badge for Girl Scouts with volunteer troop, Organized and ran nuclear science exhibit for INL Science and Engineering Expos 2004, 2005, 2006 and 2007 in conjunction with the ISU Student Section. Idaho State University Student Section (2005-2007, 2009-present) Faculty advisor for the ISU student section of the ANS. Initiated inclusion of Student Section representative to the Executive Board of the Idaho Local Section, Organize student visits to local school classrooms to discuss nuclear topics, Facilitate participation of students in annual student conference (including submission of summaries, practice presentations before conference, travel funding and arrangements). PennsylvaniaState Universit, Student Section (1994-1997) Officer and BoyScout/Girl Scout workshop developer and organizer (2 workshops each year, organized and run by students.)

Idaho State University " Elected member of the ISU Faculty Senate (2013-2016) " Organize and helped to conduct ISU NE portion of ISU's Science Trek, Hands-on introductory experience for middle school aged children (2009 - present) " Member of Engineering Academic Standards Committee (2009-present) * Appointed Member of ISU Faculty Senate subcommittee: Faculty Professional Policies Committee (2004-2007) * Elected Chair (2012-2013) and Appointed Member (2010-2012) of the ISU Faculty Research Council, reporting to the Vice-President for Research * Member of Search Committees for Dean of College of Engineering (2005-2006) and Vice President for Research (2011-2012)

International Atomic Energy Agency Consultant on International Cooperation in Nuclear Knowledge Sharingfor HumanitarianDevelopment for meeting at IAEA headquartersin Vienna, Austria,.from 13 to 15 August 2013.

1 0 th International Nuclear Graphite Specialists Meeting (INGSM-10) (September 28-30, 2009 West Yellowstone, Montana; USA) Organizing committee member with responsibilitiesincluding designing paper review process and technical session scheduling/organizing.

HONORS Professional November 2014, American Nuclear Society. Landis Public Communication and Education Award In recognition of a lifetime of passion and accomplishments in nuclear education and public communication. June 2014, American Nuclear Society Presidential Citation For her visionary leadership as chair of the Communications Committee. She has helped the Society to improve communication processes and reach out to new sectors. Mary Lou has demonstrated her commitment to improving the Societv through her involvement as a member of the Board of Directors.chair of the Fuel Cycle and Waste Management Division. and chair of the Accreditation Policy and ProceduresCommittee. June 2011, Presidential Citation for Fukushima, Japan Rapid Response In recognitionof her contributions to the response to events in Fukushima. Japan in order to ensure credible nuclear science and technology, information was provided to the media, decision makers and generalpublic. It is the dedication of members such as Mar, Lou who enable the Societ, to be relevant and a strong advocatefor the nuclear community as a whole.

Invited Speaker "The Nuclear Option: What about reprocessing?" Annual Meeting of NARUC (National Association of Regulatory Utility Commissioners), NARUC, Orlando, FL, November 2013 (Invited panelist) "Experiences of Women in Nuclear-Panel," ANS Annual Meeting, Atlanta, GA, June 2013 (Invited Panelist) "Expanding YOUR Horizons!" STEM conference for young women, conducted by Idaho Career Pioneer Network at Eastern Idaho Technical College, 12 May 2012 (Keynote speaker) "The March 2011 Earthquake and Tsunami in Japan: A Nuclear Perspective," presenter for webinar conducted by American Institute of Chemical Engineers, October 2011 (Invited presenter) "What Every High School Student Should Know About Nuclear Energy Before Attending College," National Physics Teachers' Workshop conducted by Idaho National Laboratory, 15 July 2011 (Invited speaker) "Nukes are from Neptune... and Everyone Else is from Venus and Mars." Women in Nuclear Region IV Conference, 21 July 2011 (Keynote speaker) Strategic Vision Conference, Idaho Career Pioneer Project, 5 November 2009 (Keynote speaker) "Nuclear Energy, A Postcard from South Africa," University of Cincinnati and Ohio State University graduate student seminar, 25 May, 2009 (Invited speaker) "A South African Nuclear Adventure," combined meeting of the Idaho Section of the American Nuclear Society and Women in Nuclear Region IV, 24 September 2009 (Keynote speaker) "Nuclear Power and the Environment," presentation to graduate course "Energy and the Environment" at Boise State University, March 2007 (Invited speaker) "The Inaugural World Nuclear University Summer Institute", November 2005, Washington, D.C., ANS Winter Meeting (Invited panelist) Oregon state presentation/visit "Teaching Nuclear Science in the International High School Classroom/Nuclear Fuel Reprocessing Technology in the United Kingdom" May 1993, Washington, D.C.: American Nuclear Science Teachers Association Annual Meeting (Invited speaker) "Teaching Nuclear Science in the International High School Classroom," August 1992, Washington, D.C.: American Chemical Society Summer Meeting (Invited speaker)

Research * Invited to represent the United States in a Cooperative Research Project of the International Atomic Energy Agency entitled "Treatment of Irradiated Graphite to Meet Acceptance Criteria for Waste Disposal" (2011-2014) * 2011 U.S. Department of Energy Innovations in Fuel Cycle Research Award to adyisee Tara E. Smith for her paper (presentation), Smith, T. E. and Dunzik-Gougar, M.L., "Removal of 14C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment" The finding for this award is through the Office of Nuclear Energy, Fuel Cycle Technologies. Ms. Smith was awarded a prize of $1,500.00 in the category of Universities with Less than $630 Million in 2009 Science and Engineering R&D Expenditures. * 2011 Nuclear Engineering Division of the American Institute of Chemical Engineers Outstanding Student Paper Award to advisee Tara E. Smith for Smith, T. E., McCrory, S., and Dunzik-Gougar, M.L., "Removal of 14C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment." Award consists of $500 scholarship, up to $700 support for AIChE conference attendance, and publication of paper in a peer-reviewed journal (to be determined.) * 2011 Student Conference of the American Nuclear Society, Best Presenter in the Environmental Sciences & Decommissioning, Decontamination, and Reutilization Technical Track to advisee Shilo McCrory for his presentation of McCrory, S. and Dunzik-Gougar, M.L., "Characterization of the Chemical Form of I4C in Irradiated Graphite" Award consists of recognition at Conference banquet via presentation of a plaque. * 11 th International High Level Waste Management Conference (IHLRWM) Best Poster Award to advisee Joshua Peterson for Peterson, J., Dunzik-Gougar, M.L., "Qualification Plan of Spent TRISO Fuel for Permanent Disposal", presented at IHLRWM in Las Vegas, NV, April 2006 Award consisted of $300 cash prize, financial support for meeting attendance, and plaque. 1997 Eastern Regional Student Conference of the American Nuclear Society Best Paper Award for Gougar, M.L.D., Siemer, D.D. and Scheetz, B.E., "A Vitrifiable Cement Waste Form for Disposal of Spent Nuclear Fuel Reprocessing Waste" Award was given by Conference organizers to author of full paper considered best of those submitted.

Pennsylvania State University (1994-2004) * 1995-1998: GAANN Fellowship to pursue Ph.D. in Nuclear Engineering 0 Tau Beta Pi academic honor society, Spring 1997 a Phi Kappa Phi academic honor soceity, Spring 1998

High School Teaching (1987-1994) * Grant awarded through Calvert Cliffs Nuclear Power Station to participate in the Nuclear Concepts and Technological Issues course at Penn State University for educators (summer 1989) and to use equipment, provided by Calvert Cliffs, to perform radiation detection and measurement experiments with high school classes (1987-1990).

Cedar Crest College (1983-1987) " American Chemical Society Award - Given to the most deserving graduating chemistry major " Dean's List - Five of eight semesters enrolled * Scholarships toward undergraduate education from American Business Women's Association, the Millersburg (PA, USA) Area Civic Club, and Cedar Crest College Named Scholarship Fund.

PUBLICATIONS and PRESENTATIONS Organized by research interests in the nuclear fuel cycle

Nuclear Materials Characterizationand Development LaBrier, D. and Dunzik-Gougar, M.L., "Identification and Location of 4C-Bearing Species in Thermally Treated Neutron Irradiated Graphites NBG-1 8 & NBG-25: Pre- and Post-Thermnal Treatment," Journal of Nuclear Materials, Accepted for publication, January 2015 van Rooyen, l.J., Dunzik-Gougar, M.L., van Rooyen, P.M., "Silver (Ag) Transport Mechanisms in TRISO Coated Particles: A Critical Review," Nuclear Engineering and Design, Volume 271, May 2014, Pages 180-188 4 LaBrier, D. and Dunzik-Gougar, M.L., "Characterization of 1 C in Neutron Irradiated NBG-25 Nuclear Graphite," Journal of Nuclear Materials, Volume 448, Issues 1-3, May 2014, Pages 113-120 van Rooyen, I.J., Dunzik-Gougar, M.L., van Rooyen, P.M., and Trowbridge, T., "On Techniques to Characterize and Correlate Grain Size, Grain Boundary Orientation and the Strength of the SiC Layer of TRISO Coated Particles: A Preliminary Study," peer-reviewed full paper for 6th International Topical Meeting on High Temperature Reactor Technology, HTR2012, Tokyo, October (2012) McCrory, S., Dunzik-Gougar, M.L., "A Study to Characterize the Chemical Form of 14C in Irradiated Graphite," Transactions of the American Nuclear Society, October-November 2011 McCrory, Shilo, and Dunzik-Gougar, M.L., "Characterization of the Chemical Form of 11C in Irradiated Graphite," Proceedings of the Annual Student Conference of the American Nuclear Society, April (2011) BEST PAPER IN SESSION AWARD McCrory, S.M., Dunzik-Gougar, M.L., "A Study to Remove 14C From Irradiated Graphite for Graphite Waste Volume Reduction and Recycle," Proceedings of the Annual Student Conference of the American Nuclear Society, University of Michigan, Ann Arbor, Ml, April, 2010 Skerjanc, W.F., Dunzik-Gougar, M.L., Ridgway, W.D., Siahpush, A.S., "Fuels and Materials Testing Capability for Next Generation Reactors: A Review", Transactions of the American Nuclear Society, June 2005.

Radioactive Waste Treatment Development Dunzik-Gougar, M.L. and Smith, Tara E., "Removal of Carbon-14 from Irradiated Graphite", Journal of Nuclear Materials, Volume 451, Issues 1-3, August 2014, Pages 328-335. Dunzik-Gougar, M.L., Cleaver, J., LaBrier, D., Nelson, K. and Smith, T., "Chemical Characterization and Removal of Carbon-14 from Irradiated Graphite - III," Proceedings of WM Symposium 2014, Phoenix (February 2014) Smith, Tara E., McCrory, Shilo, Dunzik-Gougar, M.L., "Limited Oxidation of Irradiated Graphite Waste to Remove Surface Carbon-14," Nuclear Engineering and Technology, Vol. 45, No. 2 (April 2013) Cleaver, J., McCrory, S., and Smith, T., and Dunzik-Gougar, M.L., "Chemical Characterization and Removal of Carbon- 14 from Irradiated Graphite - II," Proceedings of WM Symposium 2013, Phoenix (February 2013) 4 Smith, T., Cleaver, J. and Dunzik-Gougar, M.L., "Removal of 1 C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment," Transactions of the 2012 Annual Meeting of the ANS, Chicago (June 2012) Cleaver, J., McCrory, S., and Smith, T., and Dunzik-Gougar, M.L., "Chemical Characterization and Removal of Carbon- 14 from Irradiated Graphite," Proceedings of WM Symposium 2012, Pheonix (February 2012) 4 Smith, T., Cleaver, J. and Dunzik-Gougar, M.L., "Removal of 1 C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment," Transactions of the American Nuclear Society (October-November 2011) 4 Smith, T., Cleaver, J. and Dunzik-Gougar, M.L., "Removal of 1 C from Irradiated Graphite for Waste Volume Reduction and Bulk Graphite Recycle: Thermal Treatment," Proceedings of the 2011 Annual Meeting of the American Institute of Chemical Engineers, Minneapolis, MN (October 2011) AWARD WINNER Siemer, D.D., Dunzik-Gougar, M.L., "Vitrification of IFR Electrorefiner Salt Wastes", Transactions of the American Nuclear Society (June 2011) Smith, T., Dunzik-Gougar, M.L., "Removal of Carbon-14 from Irradiated Graphite for Graphite Recycle and Waste Volume Reduction: Thermal Treatment", Proceedings of the Annual Student Conference of the American Nuclear Society, Georgia Institute of Technology, Atlanta, GA (April 2011) Peterson, J., Dunzik-Gougar, M.L., "Modeling Spent TRISO Fuel for Geological Disposal: Corrosion and Failure under Oxidizing Conditions in the Presence of Water," Progress in Nuclear Energy, V.9-10, Pergamon Press, 2010. Williams, P.J., Pretorius, R., Bapela, I.1. Pete, G.A., Phihlela, L.C., Mngadi, N.S., Dunzik-Gougar,. M.L., "Viability study for the microbial treatment of radioactive graphite waste contaminated with I4C," Journal of Biotechnology, Volume 150, Supplement 1, Page 245, November (2010) Chirwa, E.C and Mary Lou Dunzik-Gougar, "Minimization of Radioactive Waste Project, Literature Review," PBMR Internal Doc. No. 003641 (2008). Dunzik-Gougar, M.L., "Minimization of Radioactive Waste Project, Phase I Work with 14C, Research Plan," PBMR Internal Doc. No. 089813, Rev. 1 (2008). Mary Lou Dunzik-Gougar, "Review of Planned Graphite Usage for the PBMR Demonstration Power Plant Report for the European Commission CARBOWASTE Project," PBMR Internal Doc. No. 102856, Rev. 1 (2008). Dunzik-Gougar, M.L. Francis van Ravenswaay, Leszek Kuczynski and Johan F.M. Slabber, "Microbial 4 2 Treatment of Irradiated Graphite for Separation of Radioisotope 1C from Bulk Graphite 1 C," Transactions of the American Nuclear Society, November 2008. Peterson, J., Dunzik-Gougar, M.L., "Qualification Plan of Spent TRISO Fuel for Permanent Disposal", 1 1th International High Level Waste Management Conference (IHLRWM) in Las Vegas, NV, April 2006 (BEST POSTER AWARD) Peterson, J., Dunzik-Gougar, M.L., "TRISO Fuel: History of the Disposal Qualification Process and Lessons Learned", Waste Management Symposium, February 2006 (poster) Johnson, C.W., Dunzik-Gougar, M.L., Li, S.X., "On-line Monitoring of Actinide Concentrations in Molten Salt Electrolyte," Transactions of the American Nuclear Society, November 2006. Tufts, P., Dunzik-Gougar, M.L., Simpson, M.F., Phongikaroon, S., "Modeling Fission Product Adsorption by Zeolite 4A in a Molten Salt," Transactions of the American Nuclear Society, November 2006. Gougar, M.L.D., Simpson, M.F., Scheetz, B.E., "Two-site Equilibrium Model for Ion Exchange between Multivalent Cations and Zeolite-A in a Molten Salt", Microporous and Mesoporous Materials, Vol. 84/1-3 pp 366-372 (2005) Simpson, M.F., Dunzik-Gougar, M.L. and Phongikaroon, S., "Modeling of Multivalent Ion Exchange Between Molten Chloride Salt and Zeolite-A," Proceedings of the American Institute of Chemical Engineers, April 2005. Simpson, M.F and Gougar, M.L.D., "Two-Site Equilibrium Model for Ion Exchange between Monovalent Cations and Zeolite-A in a Molten Salt", Ind. Eng. Chem. Res., Vol. 42, pp. 4208-4212 (2003) Gougar, M.L.D., Simpson, M.F., Scheetz, B.E., "Preliminary Verification of a New Model for Ion Exchange of Molten Salt Species in Zeolite-A," Proceedings of the Global '03 Topical Meeting of the American Nuclear Society - Atoms for Prosperity: Updating Eisenhower's Global Vision for Nuclear Energy meeting, November 2003. (full paper) Gougar, M.L.D., Simpson, M.F., Battisti, T.J., Scheetz, B.E., "Ion Exchange of Fission Products between Zeolite and a Molten Salt", Light Metals 2002, The Minerals, Metals and Materials Society, February 2002. Gougar, M.L.D., Scheetz, B.E., Siemer, D.D., "A Novel Waste Form for Disposal of Spent-Nuclear-Fuel Reprocessing Waste: A Vitrifiable Cement", Nuclear Technology, Vol. 125 (1999) Siemer, D.D., Gougar, M.L.D., Grutzeck, M. W., Scheetz, B.E., -"Preliminary Formulation Studies for a "Hydroceramic" Alternative Wasteform for INEEL HLW," Transactions of the American Nuclear Society, June 1999. Gougar, M.L.D., Herbst, R.S., Battisti, T.J., Mariani, R.D., Goff, K.M., "Ceramic Waste Form Development Studies in the Hot Fuel Dissolution Apparatus", EBR-11 Spent Fuel Treatment Program, Monthly Report, ANL-NT-76, April 1998. Gougar, M.L.D., Scheetz, B.E., and D.M. Roy, "Ettringite and C-S-H Portland Cement Phases for Waste Ion Immobilization: A Review", Waste Management, Vol. 16, No. 4, pp. 295-303 (1996) Gougar, M.L.D., Siemer, D.D., and Scheetz, B.E., "Disposal of I.N.E.L. Spent Nuclear Fuel Reprocessing Waste Using a Glass-Forming Cement.", Proceedings of the ANS Embedded Topical Meeting on DOE Spent Nuclear Fuel and Fissile Material Management, June 1996. Siemer, D.D., Roy, D.M., Grutzeck, M.W., Gougar, M.L.D., and Scheetz, B.E., "PCT Leach Tests of Hot Isostatically Pressed (HIPped) Zeolitic Concretes", Proceedings of the Materials Research Society Annual Meeting Symposium II, Scientific Basis for Nuclear Waste Management XX, December 1996. Gougar, M.L.D., D.D. Siemer, and B.E. Scheetz, "Vitrifiable Concrete for Disposal of Spent Nuclear Fuel Reprocessing Waste at I.N.E.L.", Proceedings of the Materials Research Society Annual Meeting Symposium I1, Scientific Basis for Nuclear Waste Management XIX, November 1995. Siemer, D.D., B.E. Scheetz, and M.L.D. Gougar, "Hot Isostatic Press (HIP) Vitrification of Radwaste Concretes", Proceedings of the Materials Research Society Annual Meeting Symposium II, Scientific Basis for Nuclear Waste Management XIX, November 1995

Fuel Cycle Simulation Juchau, C.A., Jacobsen, J. and Dunzik-Gougar, M.L. "Modeling the Nuclear Fuel Cycle," Nuclear Technology, Vol. 17 1, No. 2, pp. 136-141 (2010) Juchau, C., Gougar, M.L.D., Pasamehmetoglu, K., "Development of the Global Evaluation of Nuclear Infrastructure and Utilization Scenarios (GENIUS) Nuclear Fuel Cycle Systems Analysis Code," INL Technical Document, 2008 Dunzik-Gougar, M.L, Juchau, C.A., Pasamehmetoglu, K., Wilson, P.P.H., Oliver, K.M., Turinsky, P.J., Abdel-Khalik, H.S., Hays, R. and Stover, T.E., "Global Evaluation of Nuclear Infrastructure Utilization Scenarios: Initial Code Development," Proceedings of the Global '07 Topical Meeting of the American Nuclear Society, September (2007) (full paper) Juchau, C., Gougar, M.L.D., Pasamehmetoglu, K., "Simulation Institute for Nuclear Energy Modeling and Analyses (SINEMA): Developing a GENIUS", Transactions of the American Nuclear Society, June 2006. Juchau, C., Gougar, M.L.D., Pasamehmetoglu, K., "Global Evaluation of Nuclear Infrastructure Utilization Scenarios: Initial Code Development," Transactions of the American Nuclear Society, November 2006. Shropshire, D. E., Williams, K.A., Boore, W.B., Smith, J.D., Dixon, B.W., Dunzik-Gougar, M.L., Adams, R.D., 2006 Advanced Fuel Cycle Cost Basis, INL/EXT-06-11536, Official Use Only under FOIA Exemption 5, July 2006. Shropshire, D.E., Williams, K.A., Boore, W.B., Smith, J.D., Dixon, B.W., Dunzik-Gougar, M.L., Adams, R.D., "2005 Advanced Fuel Cycle Cost Basis", INEEL/EXT-04-02282 DRAFT Rev. A (2005). Shropshire, D.E., Williams, K.A., Boore, W.B., Smith, J.D., Dixon, B.W., Dunzik-Gougar, M.L., Adams, R.D., "2004 Advanced Fuel Cycle Cost Basis", INEEL/EXT-04-02282 DRAFT (from the Department of Energy's Advanced Fuel Cycle Initiative (AFCI) program systems studies, economic benefits analysis activity), 2004.

Education and Outreach Dunzik-Gougar, M.L., Lineberry, Bond, L., "The 2+2 Scholars Program: Collaborative Undergraduate Nuclear Engineering Education in Idaho," Proceedings of the 2005 American Society for Engineering Education Annual Conference and Exposition, July 2006. Dunzik-Gougar, M.L., Lineberry, M.J., Leibert, K., Mollberg, A.S., "The 2005 World Nuclear University Summer Institute: A New Focus on International Issues in Nuclear Energy Education," Proceedings of the 2006 American Society for Engineering Education Annual Conference and Exposition, July 2006. Dunzik-Gougar, M.L., Lineberry, M.J., Kunze, J.F. and Bennion, J.S., "A New Nuclear Engineering Program in the Idaho Universities," Transactions of the American Nuclear Society, November 2005. Kunze, J.F., Bennion, J.S., Lineberry, M.J., and Dunzik-Gougar, M.L., "The Idaho Universities' Role with the New Idaho National Laboratory," Proceedings of the 2005 American Society for Engineering Education Annual Conference and Exposition, 2005 Dunzik-Gougar, M.L., "ANS Local Section Joins Forces with National Laboratory for Public Information Success Story," Transactions of the American Nuclear Society, November 2004. Davison, C. and Gougar, M.L.D., "Communicating Nuclear Issues to the Public: Tools and Techniques," Transactions of the American Nuclear Society, November 2003 Dunzik-Gougar, M.L., "Beyond Selling Cookies: Girl Scouts Today; Nuclear Engineers Tomorrow?" Transactions of the American Nuclear Society, June 1997. Cornelis J. Van der Schyf, Curriculum Vitae February 6, 2015 11:03 a.m.

Current Academic Curriculum Vitae

Cornelis J. Van der Schyf (Search term on Medline/PubMed is 'Van der schyf", on IS[ databases/Web of Science use the search term "vanderschyfOR van der schyf", on Google Scholar use"van der schyf")

Citizenship: United States Citizen.

Academic Qualifications: * B.Pharm., 1978, Potchefstroom University, South Africa. * M.Sc. (Pharm.), 1981, in organic medicinal chemistry. Potchefstroom University, South Africa. * D.Sc. (eq. Ph.D.), 1983, in organic medicinal chemistry/drug design. Potchefstroom University, South Africa. * Postdoc, 1986/7, Department of Medicinal Chemistry, University of Connecticut, Storrs, CT; National Magnet Lab, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA (Prof. Alexandros Makriyannis). * Graduate Diploma in Tertiary Education, 1990, Potchefstroom University.

Professional Qualifications: * Registered (Licensed) Pharmacist with the South African Pharmacy Council, 1982-. * Registered (Licensed) Natural Scientist with the South African Council for Natural Scientists, 1983-.

Professional Career to Date: " May 1, 2013-: Dean of the Graduate School, Idaho State University, Pocatello, Idaho. * May 1, 2013-: Professor of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, Idaho. * December 5, 2013-: Graduate Faculty Member (Biomedical and Pharmaceutical Sciences), Idaho State University, Pocatello, Idaho. * December 2010-April 30, 2013: Associate Dean for Research and Graduate Studies, College of Pharmacy, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio. " July 2010-April 30, 2013: Program Director. MS and PhD degrees in Integrated Pharmaceutical Medicine, College of Graduate Studies, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio. " August 2010: Inaugural Graduate Faculty Member, College of Graduate Studies, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio. * September 2006-April 30, 2013: Professor of Pharmaceutical Sciences and Founding Chair, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio.

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* September 2006-April 30, 2013: Professor of Neurobiology, Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University (NEOMED), Rootstown, Ohio. * September 2006-April 30, 2013: Graduate Faculty Member (Physiology, Pharmacology, and Neuroscience), Kent State University School of Biomedical Sciences, Kent, Ohio. * June 2002-August 2006: Associate Professor of Pharmaceutical Sciences and Graduate Program Advisor (since Dec. 2003), Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas, and the Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas, USA. Tenured February 24, 2006. * July 1997-May 2002: Research Associate Professor, Peters Center for the Study of Parkinson's Disease, Department of Chemistry and Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. " November 1995-June 1997: Senior Research Scientist, Peters Center for the Study of Parkinson's Disease, Department of Chemistry and Adjunct Faculty Member, Department of Biomedical Sciences and Pathobiology, Virginia- Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. * January 1990-November 1995: Professor of Pharmaceutical Chemistry and Head, Department of Pharmaceutical Chemistry, and Director: Drug Metabolism Research Unit, Potchefstroom University (currently North West University), Potchefstroom, South Africa. * January 1985-December 1989: Associate Professor, Department of Pharmaceutical Chemistry, Potchefstroom University, Potchefstroom, South Africa. Tenured January 1, 1986. * June 1986-July 1987: Postdoctoral Research Scientist (as visiting Assistant Professor), Department of Medicinal Chemistry, University of Connecticut, Storrs, Connecticut, U.S.A. " March 1984-December 1984: Senior Lecturer (eq. U.S. Assistant Professor), Dept. of Pharmacology, School of Medicine, University of Pretoria, Pretoria, South Africa. * November 1980-February 1984: Research Scientist (later Senior Research Scientist and Project Leader), Synthesis group, Central Research Laboratory, Noristan Ltd., Pretoria, South Africa. * January 1979-October 1980: Research Assistant, Dept. of Pharmaceutical Chemistry, Potchefstroom University, Potchefstroom, South Africa. Visiting/Honorary Professorships: * January 2010-: Extraordinary Professor Emeritus, School of Pharmacy, North West University, Potchefstroom, South Africa. * January 1997-December 2009: Extraordinary Professor, School of Pharmacy, North West University (formerly Potchefstroom University), Potchefstroom, South Africa (an honorary appointment).

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" May 1995: Visiting Professor, Department of Medicine, Pharmacology and Toxicology, University of Queensland, Brisbane, Queensland, Australia. " May 1993-October 1993: Visiting Professor and Senior Research Scientist, Peters Center for the study of Parkinson's Disease, Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA. Company Board Membership/Directorship: * 1990-1995: Senior Partner, Zeta-T Technical Translation Service, Potchefstroom, South Africa. * 1991-1995: CEO and Chairman of the Board, OrphMed Pharmaceuticals CC, Potchefstroom, South Africa. * 2006- : Secretary and Member of the Board of Directors, Tebraco Inc., Lubbock, Texas. External Advisory Board Membership: * External Advisory Board Member: Center for Drug Discovery and Innovation (a collaborative Center of Excellence between Cleveland State University, Case Western Reserve University, The Cleveland Clinic, and Northeast Ohio Medical University). " Member: Northeast Ohio Medical University's Institute of Neurobehavioral Health (an Ohio Board of Regents Center of Excellence) Specialist Experience: * October 3-4, 2011: Evaluator Training: Accreditation Council for Pharmacy Education (ACPE) Workshop, Chicago, IL. * January 1994: Credit Course in Experimental Animal Research, Experimental Animal Center, Potchefstroom University, South Africa. * May 1993-October 1993: Drug metabolism studies in the Peters Center and the Virginia Tech Laboratory Animal Resources Facility, Blacksburg, Virginia, USA. * March 1990-1995: Management Courses (Financial, Research, Personnel) offered by the Graduate School of Business, Potchefstroom University, South Africa. * June 1986-July 1987 and June 1988: Nuclear magnetic resonance (NMR) at the Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, U.S.A. * June 1984: Electrophysiological work done on new calcium antagonists (synthesized in my laboratory), at the MRC Unit of Ischemic Heart Disease at the Medical School, University of Cape Town, Cape Town, South Africa. " June-July 1980: X-ray crystallographical and structural work done in the Department of Theoretical Chemistry, National Chemical Research Laboratory, CSIR, Pretoria, South Africa. Techniques: NMR, LC/MS, LC/MS-MS, GC/MS, GC, HPLC, MS, FT/IR, SPECT, organic syntheses, computational medicinal chemistry and molecular graphics on various

-3 of 58- Cornelis J. Van der Schyf, Curriculum Vitae February 6, 2015 11:03 a.m. platforms/software packages, general pharmacology, enzymology and toxicology techniques. Very proficient in microcomputing. Grants Funded or Under Review as Principal Investigator (PI) or co-PI/Co- Investigator: In Preparation NINDS R-21, "Novel Dual-Action Drugs in a Stroke Model". Total Request $368,538-00 over 2 years, (PI). 2011 -2012 Fight for Sight Grant-In-Aid: "Testing multifunctional drugs in glaucoma." Total direct costs $20,000 over 1 year, (as Consultant with Dr. Samuel Crish, PI, Pharmaceutical Sciences, NEOMED). 2008-2010 Integrated Biosciences Research Incentive Grant, University of Akron, "Study of electrostatic perturbation in neurons and endothelial cells under stress using Atomic Force Microscopy- assisted Electrostatic Nanolithography and a BioScope instrument". Total direct costs $10,000 (shared 50/50 between PIs) over 1 year, extended 2 years (as Co-principal investigator with Dr. Sergei Lyuksyutov, Department of Physics, University of Akron). 2006-2008 NIH/NIA, "Age-related Hypertension & Endothelial LCFACoAS- mediated eNOs Palmitoylation". NIH # 1 R21 revised HL081388- 01, Total direct costs $299,675-00 over 2 years, (As Co- investigator with Margaret Weis, Dept. of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy). 2004 - 2007 Neuropsychiatry Alzheimer's Disease Fund. "New Alzheimer's Disease Therapies - Establishment of a Drug Development Core Facility", 1 Sep. 2004 - 31 Aug. 2007. Total direct cost $180,000- 00, (P1). 2004 -2009 NIH # 1R01NS046526-O1A1 in NINDS "Tobacco Smoke Chemicals and Stroke Alter Brain K' Efflux", 1 Jul. 2004 - 31 Mar. 2009. Total direct cost $1,250,000-00, (As Co-investigator with PI Thomas Abbruscato, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy). 2003 - 2004Texas Tech University Health Sciences Center Institute for Healthy Aging (IHA) Grant Program 2003-2004 "Novel Drugs with a Dual Mechanism of Action for the Prevention and/or Treatment of Alzheimer's Disease". Total direct costs $49,590-00 over 1 year, (PI, Co-investigator is J. Klein, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center School of Pharmacy). 2001 - 2003 Research Grant, Park Foundation, Inc, Ithaca, New York, Proposal # 01-2116-05 "Cage Amines as Therapeutics for Parkinson's Disease", Total direct costs: $50,000-00, (As Co-PI with Jeffrey Bloomquist, Neurotoxicology Lab, Entomology Department, Virginia Tech). 2000 - 2001 ASPIRES Grant, Virginia Polytechnic Institute and State University. "Impact of Tobacco on Relationships Between Monoamine Oxidase Activity, EEG Activity and Behavior: Interdisciplinary Animal and Human Studies", Total $42,200-00,

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(As co-PI with Neal Castagnoli, Jr., Chemistry Department and Helen Crawford, Psychology Department). 1999 - 2000 Seed Grant, VA-MD Regional College of Veterinary Medicine, RFU for Environmental Medicine & Toxicology, Total: $2,050-00, (As PI). 1998- 2000 NIH # 1RO1DA11089-OlA1 in NIDA PA-95-038, Neuroscience Research Of Nicotine And Nicotine Abuse, FRS # 431315 "Inhibition of MAO A and MAO B by Tobacco Alkaloids", 20 Jan. 1998 - 31 Dec. 2000. Total $492,032-00, (As co-investigator with Neal Castagnoli, Jr., PI, Chemistry Department). 1997 - 1998 The Council for Tobacco Research - U.S.A., Inc. Grant No. 4728, FRS # 435803 "Neuroprotection Through MAO Inhibition by Tobacco Alkaloids?", Total $136,130-00, (As co-PI with Neal Castagnoli, Jr., Chemistry Department). 1996- 2009 Endowment Grant, Extraordinary Professor of Pharmaceutical Chemistry, North West University, South Africa, Approximate annual budget $10,000, Approximate Total Budget: $130,000-00, (As PI). 1985 - 2007 "VERKA" awards for published work, Potchefstroom University. 1987 - 1995 Committee for Foreign Relations, Potchefstroom University. 1992 - 1994 Medical Research Council Research Support Grant (PI). 1985 - 1993 Foundation for Research Development, CSIR, Rolling Research Grant (PI). 1993 - 1993 Award for Sabbatical Leave: Foundation for Research Development, CSIR (PI). 1991 &1992 Foundation for Research Development, Stipend Award (PI). 1989 - 1990 Medical Research Council Pilot Study Grant (PI). 1986 - 1987 Award for Sabbatical Leave: Foundation for Research Development, CSIR (PI). 1986 - 1987 Scientific Advisory Committee to Noristan Grant (PI). 1986 - 1986 University of Connecticut Research Foundation Grant (PI). 1985 - 1985 Committee for Foreign Relations Grant, Potchefstroom University (PI). 1983 - 1985 Scientific Advisory Committee to Noristan Grant (PI). 1980 - 1983 Scientific Advisory Committee to Noristan Grant (PI). 1979 - 1980 Proprietary Association Research Grant - Foundation for Pharmaceutical Education (PI). Prizes, Awards and Honors: Administrative Excellence Awards: 2010: Olson/Blair Award for Administrative Excellence, Northeast Ohio Medical University (NEOMED).

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Research Prizes/Awards: 2006: Bioorganic & Medicinal Chemistry Most Cited Paper 2003-2006 Award. 2005: FARMOVS Prize in Pharmacology and Drug Development of the South African Academy of Science and Arts (this is South Africa's most prestigious award in the fields of pharmacology and drug research). 2001: Academy of Pharmaceutical Sciences Award for Best Publication (Medicinal Chemistry) in 2000. 1994: Upjohn Achievement Award (Pharmacology) in the Academy of Pharmaceutical Sciences. 1990: Evaluated by Foundation for Research Development (FRD) in category "C", described as "consistent research scientists with regular international exposure". 1985: Evaluated by Foundation for Research Development of the CSIR in a category "Y", described as "excellent young researchers (younger than 35)". 1975: Merit Prize for Undergraduate Academic Achievement, University of Pretoria. Teaching Awards: 2005: Teaching Team of the Year Award, Pharm.D. Class of 2008, Texas Tech University Health Sciences Center School of Pharmacy. 2004: Teaching Team of the Year Award, Pharm.D. Class of 2007, Texas Tech University Health Sciences Center School of Pharmacy. 2003: Teacher of the Year Award, Texas Tech University Health Sciences Center School of Pharmacy Pharm.D. Class of 2004, and American Association of Colleges of Pharmacy. Honors:

2006-7: Profiled in: Who's Who In Medicine and Healthcare, 6th Edition, 2006- 2007, Marquis Who's Who (Publishers), New Providence, New Jersey. 2012-: Profiled in: Who's Who in South Africa, http://whoswho.co.za/cornelis-j- van-der-schyf-1 264343 Membership and Executive Bodies of Professional and Honor Societies: * American Association of Colleges of Pharmacy (AACP) * Academy of Pharmaceutical Sciences of South Africa (Member of the Executive Committee, serving in variety of positions from 1988-1995; President of this Academy, 1992-1993; Vice-president, 1994-1995). " Neurotoxicity Society (Founder Member) * Society for Neuroscience " American Association of Pharmaceutical Scientists * Drug Design and Discovery (DDD) Section * National Biotechnology Conference Screeners Committee 2008-2009 " Student/Postdoc Committee 2008-2009

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" American Chemical Society, and Member: Division of Medicinal Chemistry (1982) * New York Academy of Sciences * Phi Beta Delta Honor Society for International Scholars * Ohio Society of Health-System Pharmacists * South African Chemical Institute " South African Pharmacological Society • Pharmaceutical Society of South Africa " Full Member of The South African Academy for Science and Arts * Sigma Xi, The Scientific Research Society Editorial Board Membership (current and former): * Editor-in-Chief, Journalof Biophysical Chemistry (2010-) * Member, Editorial Advisory Board: BMC Pharmacology and Toxicology (2012-) " Member, Editorial Board: Expert Opinion on Drug Discovery (2011-) * Member, Editorial Board: International Journal of Brain and Cognitive Sciences (2011- ) * Member, Editorial Board: Journalof Biophysical Chemistry (2009-2010) * Member, Editorial Advisory Board: LitNet Akademies (Natuurwetenskappe) (2011-) * Member, Editorial Board: Medicinal Chemistry Research (2012-2017) * Member, Editorial Board: Molecules (2003-2009) * Member, Editorial Board: Neurotoxicity Research (2011-2013) " Member, Editorial Advisory Board: Open Medicinal Chemistry Journal(2008-) * Member, Editorial Board: Pharmaceutics & Novel Drug Delivery Systems: CurrentResearch (2011- ) * Member, International Advisory Board: South African Journal of Chemistry (2008-) * Guest Editor (invited), January 2009 Edition: Neurotherapeutics Peer-Reviewer for Journals: * Peer reviewer: Archiv der Pharmazie " Peer reviewer: American Journalof PharmaceuticalEducation * Peer reviewer: Bioorganicand Medicinal Chemistry * Peer reviewer: Bioorganic and Medicinal Chemistry Letters " Peer reviewer: BioorganicChemistry " Peer reviewer: Biopolymers * Peer reviewer: Chemical Research in Toxicology * Peer reviewer: Current CancerDrug Targets * Peer reviewer: Current Drug Targets * Peer reviewer: Current Medicinal Chemistry * Peer reviewer: Current PharmaceuticalBiotechnology * Peer reviewer: Currents in Pharmacy Teaching and Learning * Peer reviewer: Drug News and Perspectives * Peer reviewer: European Journalof Medicinal Chemistry * Peer reviewer: Expert Opinion on Drug Discovery * Peer reviewer: The FASEB Journal

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* Peer reviewer: Food and Chemical Toxicology * Peer reviewer: Histology and Histopathology * Peer reviewer: Human and Experimental Toxicology * Peer reviewer: The InternationalJournal of Biochemistry & Cell Biology * Peer reviewer: The InternationalJournal of Neuropsychopharmacology * Peer reviewer: InternationalJournal for Vitamin and Nutrition Research " Peer reviewer: Journalof Agricultural and Food Chemistry * Peer reviewer: Journalof Alzheimer's Disease * Peer reviewer: Journalof Biophysical Chemistry " Peer reviewer: Journalof CombinatorialChemistry * Peer reviewer: Journalof Neurochemistry * Peer reviewer: Journalof Neuroscience Research * Peer reviewer: Journalof Pharmacology& Experimental Therapeutics " Peer reviewer: Journalof Pharmacy & PharmaceuticalSciences * Peer reviewer: Life Sciences * Peer reviewer: Letters in Drug Design & Discovery * Peer reviewer: Medicinal Chemistry Research * Peer reviewer: Medicinal Research Reviews " Peer reviewer: Molecules * Peer reviewer: Neurodegenerative Diseases * Peer reviewer: Neurobiology of Learning and Memory * Peer reviewer: Neurotoxicity Research " Peer reviewer: Neuropharmacology * Peer reviewer: NeuroToxicology * Peer reviewer: Nutritional Neuroscience * Peer reviewer: Phytochemistry " Peer reviewer: PharmacologicalResearch * Peer reviewer: PLOS ONE * Peer reviewer: South African Journalof Chemistry * Peer reviewer: Therapy

Research Interests: * Chemical syntheses and pharmacology of novel drugs, currently focused on polycyclic multiple mechanistic: " neuroprotective drugs * thioacridone anticancer and antimalarial agents * phlorophenone antimicrobial compounds. * De novo drug design using molecular connectivity as well as several empirical methods, including ethnobotanical and ethnopharmacological sources, for lead generation. * Pharmacological and electrophysiological testing of series of these compounds with a view to obtain predictive (quantitative) structure-activity relationships. * Receptorology studies involving molecular modeling studies on polycyclic amines acting as calcium channel and NMDA receptor antagonists. " Studies on drug-membrane interactions, focused on tetrahydrocannabinols in early collaboration with the group of Dr A. Makriyannis (University of Connecticut, currently at Northeasten University, Boston, MA), U.S.A.

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* Studies on drug metabolism and neurotoxicology/neuroprotection, focused on haloperidol and its derivatives, done in collaboration with Dr Neal Castagnoli, Jr., Peters Professor of Chemistry, and his group at the Peters Center, Virginia Tech, Blacksburg, VA, USA, Dr Susan M. Pond, Director Research, Johnson & Johnson Research Pty Ltd, North Sydney, NSW and colleagues at Department of Medicine, University of Queensland, Brisbane, Queensland, Australia and Drs Johan Wouters and Fred Ooms, Facultes Universitaires Notre-Dame de la Paix, Namur, Belgium. * Primate research.

Research Impact Metrics: Number of Citations:2,374 H-Index: 30 i10-Index: 66 National Higher Education and Professional Accreditation Experience: * The Northwest Commission on Colleges and Universities (NWCCU) Accreditation processes, Idaho State University, ID, 2013 - 2014 (details provided elsewhere under "University Service"). * Accreditation Council for Pharmacy Education (ACPE) Accreditation Team Member: Comprehensive Site Visit of Chicago State University College of Pharmacy, April 11-13, 2012. * Accreditation Council for Pharmacy Education (ACPE) Accreditation processes, College of Pharmacy, Northeast Ohio Medical University, Rootstown, OH, 2006 - 2011 (details provided elsewhere under "University Service"). " Liaison Committee on Medical Education (LCME) Accreditation processes, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, 2009 - 2011 (details provided elsewhere under "University Service"). * The Higher Learning Commission of the North Central Association of Colleges and Schools (NCA) Accreditation processes, Northeast Ohio Medical University, Rootstown, OH, 2009 - 2012 (details provided elsewhere under "University Service"). " Accreditation Council for Pharmacy Education (ACPE) Accreditation processes, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 2004 - 2005 (details provided elsewhere under "University Service"). " Southern Association of Colleges and Schools (SACS) Accreditation processes, Texas Tech University Health Sciences University School of Pharmacy and Graduate School of Biomedical Sciences (GSBS), August 2002 - October 2003. Amarillo, TX and Lubbock, TX. International and Federal Agency Service, NIH Study Sections, etc.: * Expert Reviewer (2013) Exact Sciences & Engineering 2013 Call, - Fundaq;o para a Cidncia e a Tecnologia (FCT), Lisboa, Portugal. * Peer Reviewer (2013) Biotechnology Research Grant Program of the North Carolina Biotechnology Center.

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* Peer Reviewer for the Medical Research Council (MRC), UK, 2010- current. * Expert Reviewer (2012) Exact Sciences & Engineering 2012 Call, - Fundago para a CiC-ncia e a Tecnologia (FCT), Lisboa, Portugal. " Chartered Member (November 2007 - October 2011) of the following NIH Study Section: NINDS Neurological Sciences and Disorders C NSD-C. " Expert Reviewer: Skolkovo Foundation, Moscow, Russian Federation, 2011, 2012. " Expert Reviewer: Medical Research Council, London, Swindon, Wiltshire, United Kingdom, 2010. " Member (2007) of the following NIH Study Section: NIA Special Emphasis Panel Review Committee ZAG1 ZIJ-7 (J2) "Prion Diseases". " Ad Hoc Member (2007) of the following NIH Study Section: NINDS Neurological Sciences and Disorders C NSD-C. " Ad Hoc Member (2007) of the following NIH Study Section: Biomarkers for Neurodegenerative Diseases, ZNS1 SRB-B (01) (1). " Ad Hoc Member (2005) of the following NIH Study Sections: 1) Drug Discovery & Development Study Section, ZRG1-DDD/BCMB-11; 2) Clinical Neuroplasticity and Neurotransmitters Study Section: Brain Disorders and Clinical Neuroscience Integrated Review Group, CNNT/BDCN-2. " Peer-Reviewer for The Petroleum Research Fund, administered by the American Chemical Society, 2005. " Peer-Reviewer on the Alzheimer's Association's Alzheimer's Review Committee (ALZ20xx) 2004, 2005, 2006, 2008, 2009, 2011 and 2014 grant review cycles. " Ad Hoc Member (2004) of the following NIH Study Sections: 1) NIH Special Emphasis Panel: Drug Development and Delivery, ZRG1 SSS-L; 2) Clinical Neuroplasticity and Neurotransmitters Study Section: Brain Disorders and Clinical Neuroscience Integrated Review Group, CNNT/BDCN-2. " Ad Hoc Member (2002) of the NIH/National Cancer Institute (NCI) Special Emphasis Panel Study Section, ZCA1 SRRB-Q (Ml) for the International Tobacco and Health Research and Capacity Building Program. " Peer-Reviewer for the U.S. Civilian Research & Development Foundation Cooperative Grants Program, 2001. " Peer-Reviewer for the South African National Research Foundation (NRF) Grants Program, 2000 - current. " Member Medicines Control Council of South Africa (South African equivalent of the US FDA): Complementary Medicines Committee, 1994-. " Examiner for Pharmaceutical/Medicinal Chemistry for the South African Pharmacy Council National Professional Examination, 1994-1995. " Member, Course Design Committee for Pharmaceutical/Medicinal Chemistry for the South African Pharmacy Council National Board Examination, 1995. " Council Member, Evaluation Committee for Pharmaceutical Sciences, Foundation for Research Development (FRD), South Africa, 1993-1995.

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* Ad Hoc Reviewer for the South African Medical Research Council (MRC) Grants Program, 1991 - current. University Service: * Member, Search Committee for the Director, Medical Laboratory Sciences: Idaho State University, 2014. * Member, Search Committee for the Associate Vice-President for Enrollment Management: Idaho State University, 2014. * Member, Search Committee for the Controller: Idaho State University, 2014. * Member, Search Committee for the Associate Vice-President for Academic Affairs and the Associate Vice-President for Institutional Effectiveness: Idaho State University, 2013. " Charter Member, NEOMED Graduate Faculty Council, Northeast Ohio Medical University, Rootstown, OH, July 2012-April 30, 2013. * Member Appointments and Promotions Committee, Northeast Ohio Medical University, Rootstown, OH, July 2012-April 30, 2013. * Member, Interprofessional Education Task Force, Northeast Ohio Medical University, College of Medicine, Rootstown, OH, July 2012- April 30, 2013. * Member, M1/M2 Foundations Curriculum Team, Northeast Ohio Medical University, College of Medicine, Rootstown, OH, January 2012- April 30, 2013. * Chairperson,Institutional Review Committee for the Office of Research and Sponsored Programs (ORSP), January 2011 - February 2012. * Member, NEOMED Schizophrenia Research Scholarship Oversight and Selection Committee, Northeast Ohio Medical University, Rootstown, OH, November 2011-April 30, 2013. * Member, NEOMED Faculty Compensation Plan Steering Committee (in consultation with ECG Management Consultants), Northeast Ohio Medical University, Rootstown, OH, November 2011-April 30, 2013. * Co-author, Memorandum of Understanding and Cooperation between Cleveland State University and NEOMED, March 2011. " Member, The Higher Learning Commission of the North Central Association (NCA) Self-study Criterion Three Committee, Northeast Ohio Medical University, Rootstown, OH, March 2010- April 30, 2013. * Member, College of Graduate Studies Transition Team, Northeast Ohio Medical University, Rootstown, OH, March 2010. " Executive Member, Northeast Ohio Medical University's Higher Learning Commission of the North Central Association of Colleges and Schools (NCA) Self-study Committee, Rootstown, OH. Participated as Founding Director of the MS and PhD Program in Integrated Pharmaceutical Medicine in the following accreditation status events for the new College of Graduate Studies:

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* For approval by The Higher Learning Commission of the NCA of the M.S. and Ph.D. Degrees in Integrated Pharmaceutical Medicine: Jul. 2009 - Dec. 2009, progress report; * December 7-8, 2009, focused on-site evaluation. Adjunct Graduate Faculty - Professor of Pharmaceutical Sciences, Graduate School of Biomedical Sciences (GSBS), Texas Tech University Health Sciences Center, Lubbock, TX, 2007-. * Member, Academic Council, Northeast Ohio Medical University, Rootstown, OH, 2006 - April 30, 2013 (ex officio). " Member, Liaison Committee on Medical Education (LCME) Faculty Self- study Subcommittee, For Continuing Full Accreditation, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, 2009 - 2011. * Member, Graduate Education Task Force, Northeast Ohio Medical University, Rootstown, OH, May-August, 2009. " PrimaryAuthor/Architect and co-Presenter to the Ohio Regents' Advisory Committee on Graduate Studies (RACGS): "Full Proposal of the Graduate Program in Integrated PharmaceuticalMedicine Master of Science and Doctor of Philosophy Degrees Offered by the Northeast Ohio Medical University", Rootstown and Columbus, OH, April 2009, presented to and approved by RACGS on July 24, 2009. The timeline of my involvement from September 2007 until 2009 was as follows, and also led to the creation of the College of Graduate Studies: " The Northeast Ohio Medical University Board of Trustees was notified of the submission of a Notice of Intent to RACGS for a new graduate degree - September 28, 2007; * ACPE was notified of intent to offer the new degrees in a progress report - February 15, 2008; * Full proposal was submitted to RACGS - May 7, 2009; * Northeast Ohio Medical University Academic Council approved all proposed new degrees - June 3, 2009; * RACGS approval - July 24, 2009; * Ohio Board of Regents approval - September 16, 2009; * Northeast Ohio Medical University Board of Trustees approve the creation of a College of Graduate Studies to house the three new requested programs - September 18, 2009. • Program expanded to accommodate dual degrees: M.D./Ph.D., Pharm.D./Ph.D., M.D./M.S., Pharm.D./M.S. - August 2011. * First two students admitted into Program, one M.D./Ph.D., one Ph.D. - August 2011. * Program expanded to five students with the admission of three additional students: one M.D./Ph.D. and two M.S. -August 2012.

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* Member, Admissions Committee (COP), Northeast Ohio Medical University, Rootstown, OH, 2006-2011. * Member, Search Committee, President: Northeast Ohio Medical University, Rootstown, OH, 2009. " Member, Institutional Biosafety Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-2010. " Member, Institutional Safety Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-2010. * Member, Intellectual Property Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-2010. " Member, Outstanding Faculty Research Award Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-April 30, 2013. * Member, Graduate Coordinating Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-April 30, 2013. * Member, Research Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-2010. " Chair, Tenure and Promotions Committee, Northeast Ohio Medical University, Rootstown, OH, July 2007- June 2011. * Member, Tenure and Promotions Committee, Northeast Ohio Medical University, Rootstown, OH, 2006-2007. * Member, Institutional Review Committee for the Office of Continuing Professional Education, Northeast Ohio Medical University, Rootstown, OH, ad hoc, 2007. * Member, Faculty Development Advisory Group, Northeast Ohio Medical University, Rootstown, OH, 2006-April 30, 2013. * Member, Faculty Bylaws Steering Committee, Northeast Ohio Medical University, Rootstown, OH, 2006. * Executive Member, Northeast Ohio Medical University's Accreditation Council for Pharmacy Education (ACPE) Self-study Committee, Rootstown, OH. Participated as Founding Department Chair of Pharmaceutical Sciences in the following accreditation status events for the new College of Pharmacy: * For College of Pharmacy Precandidate Status: Oct. 24-26, 2006, on-site evaluation; * For College of Pharmacy Candidate Status: Jan. 2007-Feb. 2008, progress report; * April 1-3, 2008, comprehensive on-site evaluation. * For Continuation of College of Pharmacy Candidate Status: May. 2008- Feb. 2010, progress report; * March 23-24, 2010, focused on-site evaluation. * For College of Pharmacy Full Accreditation: April 2010-Feb. 2011, self- study report; " April 5-7, 2011, comprehensive on-site evaluation.

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* Member, Search Committee, Regional Dean: TTUHSC School of Pharmacy, Abilene, TX, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, 2006. * Chair, Ad Hoc Committee on bulk Email, Texas Tech University Health Sciences University School of Pharmacy, 2005. Amarillo, TX. * Member, Ad Hoc Committee on International Exchanges, Texas Tech University Health Sciences University School of Pharmacy, 2005. Amarillo, TX. " Secretary, Graduate Council and Graduate Faculty, Texas Tech University Health Sciences University Graduate School for Biomedical Sciences, 2005 - 2006. Lubbock, TX. * Member, Accreditation Council for Pharmacy Education (ACPE) Self- Study Committee, Texas Tech University Health Sciences Center School of Pharmacy, 2004 - 2005. Amarillo, TX. " Member, Search Committee, Senior Funded Faculty Position in Cancer Research, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, 2005. " Chair, Ad Hoc Technology Advisory Committee, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, 2005 - 2006. * Member, Ad Hoc Technology Advisory Committee, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, 2004 - 2005.

* Panel of Judges, 16 th Annual Student Research Week, March 29 - April 2, 2004. Texas Tech University Health Sciences Center, Lubbock TX. " Member, Executive Committee, Texas Tech University Health Sciences University School of Pharmacy, 2003 - 2004. Amarillo, TX. * Member, Southern Association of Colleges and Schools (SACS) Self- Study Committee, Texas Tech University Health Sciences University School of Pharmacy and Graduate School of Biomedical Sciences, August 2002 - October 2003. Amarillo and Lubbock, TX. " Panel of Judges (Pharmaceutical Sciences), Second Annual Research Days Event, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas, June 2-3, 2003. * Chairperson, Student Liaison Committee, School of Pharmacy, Potchefstroom University, 1993 - 1995. * Chairperson, Ethics Committee: Medical, Potchefstroom University, 1993 - 1995. * Chairperson, Faculty Education Committee, School of Pharmacy, Potchefstroom University, 1991 - 1995. * Member, University Senate, Potchefstroom University, 1990- 1995. * External Examiner, Medicinal Chemistry, B.Pharm. II, Ill and IV, University of the Witwatersrand, 1989 - 1997. * External Examiner, Medicinal & Pharmaceutical Chemistry, B.Pharm. IV, University of Durban-Westville, 1988 - 1996.

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" Chairperson, Faculty Advisory Committee on Computer-based Hardware, Potchefstroom University 1988. * Member, Faculty Council, School of Pharmacy, Potchefstroom University, 1985-1995. * Chairperson, Advisory Committee to Review Toxic Waste Disposal, Potchefstroom University, 1985 - 1989. " Member, Faculty Council, Medical School, University of Pretoria, 1984. University Level Teaching: * Graduate Instruction, Course Director, Transitions to Pharmaceutical Medicine (16 x 2 hr. lectures), Integrated Pharmaceutical Medicine Graduate Program, College of Graduate Studies, Northeast Ohio Medical University, Fall 2011, Fall 2012. " M.D. and Pharm.D. Instruction, Brain, Mind and Behavior (4 x 50 min. lectures), College of Medicine, Northeast Ohio Medical University, Rootstown, Spring 2008 - 2013. " Graduate Instruction, Research Methods in Neuroscience (1 x 50 min. lecture), Neuroscience Graduate Program, School of Biomedical Sciences, Kent State University, Spring 2008 - 2013. * Pharm.D. Instruction, Pharmacotherapeutics (Infectious Diseases Module) (8 x 50 min. lectures), College of Pharmacy, Northeast Ohio Medical University, Rootstown, Fall 2008 - 2011. * Pharm.D. Instruction, Film in Pharmacy (Elective) (2 x 4 hr. sessions), College of Pharmacy, Northeast Ohio Medical University, Rootstown, Spring 2008-2011. * Pharm.D. Instruction, Principles of Drug-Body Interactions (10 x 50 min. lectures), College of Pharmacy, Northeast Ohio Medical University, Rootstown, Fall 2007 - 2012. * Pharm.D. Instruction, Nutraceuticals (2 x 50 min. lectures), College of Pharmacy, Northeast Ohio Medical University, Rootstown, Fall 2007 - 2012. " Pharm.D. Instruction, Pharmacotherapeutics (Endocrine Module) (4 x 50 min. lectures), College of Pharmacy, Northeast Ohio Medical University, Rootstown, Fall 2008 - 2012. * Pharm.D. Instruction, Pharmaceutics with Laboratory (10 x 50 min. lectures), Northeastern Ohio Universities College of Pharmacy, Rootstown, Fall 2007. * M.D. Instruction, Brain, Mind and Behavior (4 x 50 min. lectures), Northeastern Ohio Universities College of Medicine, Rootstown, Spring 2007. * Graduate Instruction, Medicinal Chemistry (11 x 110 min. lectures, newly developed course and Instructional Team Leader - GPSC 5301), Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences & School of Pharmacy, Amarillo, Spring 2004, Spring 2006, this course is now a Core Curriculum Course for the Pharmaceutical Sciences Graduate Program. * Pharm.D. Instruction, Principles of Drug Action (18 x 50 min. lectures - PHAR 2325), Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Spring 2004, Spring 2005, Spring 2006.

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" Pharm.D. Instruction, Herbal Products and Nutraceuticals (5 x 50 min. lectures, and Instructional Team Leader - PHAR 4128), Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Fall 2003, Fall 2004, Fall 2005. * Pharm.D. Instruction, Herbals, Complementary, and Alternative Medicines (5 x 50 min. lectures, and Instructional Team Leader - PHAR 4228), Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Spring 2003. " Pharm.D. Instruction, Pharmacotherapy IX - Integumentary Pharmacotherapy (5 x 70 min. lectures - PHAR 4159), Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, 2002, 2003. " Pharm.D. Instruction, Pharmacotherapy XII - Psychiatric Pharmacotherapy (5 x 70 min. lectures - PHAR 4262), Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Fall Semester 2002, 2003, 2004, 2005. " Graduate Instruction, Drug Metabolism (6 x 120 min. lectures, and Instructional Team Leader - GPSC 5320), Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences & School of Pharmacy, Amarillo, Summer 2003, 2006. " Graduate Instruction, Lab Rotations, 1 x 8 week session (GPSC 5307, Ph.D. Candidate Joachim Hartmann), Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences & School of Pharmacy, Amarillo, 2003. * Graduate Instruction, Lab Rotations, 2 x 8 week sessions (GPSC 5307, Ph.D. Candidate Nusrat Motlekar), Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences & School of Pharmacy, Amarillo, 2002 - 2003. " Graduate Instruction, General Neurochemistry (3 x 180 min. lectures - VMS 5324), Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1996 -2002. * Advanced Undergraduate Instruction, Drug Chemistry (2 x 50 min. lectures 1997, 3 x 50 min. lectures 1998 - CHEM 4554) Department of Chemistry, Virginia Polytechnic Institute and State University, 1997 -2002. * B. Pharm. Instruction, Medicinal Chemistry Ill, Potchefstroom University School of Pharmacy, Potchefstroom, South Africa, 1985 - 1995. Major Advisor: Graduate Students and Postdoctoral Associates Supervised (Research): * Wilna Liebenberg, Potchefstroom University, 1985-1986, M.S. dissertation: Nitrogen-containing derivatives of pentacyclo-undecane. A new series of calcium channel blockers. Degree awarded cum laude. * DanieI P. Prinsloo, Potchefstroom University, 1986-1987, M.S. dissertation: Hemodynamic aspects of a new series of calcium channel blockers. * Riaan Bornman, Potchefstroom University, 1986-1987, M.S. dissertation: Correlationbetween stereochemistry and calcium channel blocking activity of pentacyclo undecane derivatives.

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* Petro Snyman, Potchefstoom University, 1987-1988, M.S. dissertation: Structural requirements for modelled biological interactions of polycyclic calcium channel blockers. Degree awarded cum laude. * Wilna Liebenberg, Potchefstroom University, 1986-1988, Ph.D. dissertation: The syntheses, conformations and biological activities of triquinyl derivatives and related compounds. * Rosemary Allin, University of Stellenbosch/Potchefstroom University, 1985- 1988, Ph.D. dissertation: Radioligand displacement to measure concentrations of catecholaminergicdrugs. * Karin Swanepoel, Potchefstroom University, 1989-1990, M.S. dissertation: Antimicrobial activity of triquinyl amines. * Gisella Dockendolf, Pothefstroom University, 1991-1992, M.S. dissertation: Novel calcium antagonistswith polycyclic structures. * Adolf Mattheus (co-supervisor), 1994-1995, Potchefstroom University, M.S. dissertation: The solubility and dissolution characteristicsof Furosemide. * Sarel F. Malan, Potchefstroom University, 1991-1997, Ph.D. dissertation: Extended development of polycyclic amino ethers as ligands on the membrane-bound ion channels. A study aimed at the design of novel ion active drugs. " Ilze Van den Heever, Potchefstroom University 1992-1998, M.S. dissertation: Enterotoxins as cardiac dysrhythmic agents - a study in post miocarditis arrhythmias. * Gisella Dockendolf, Potchefstroom University, 1992-1998, Ph.D. dissertation: Haloperidol and haloperidol metabolites: structural studies and molecular modeling. " Ron~l Keev6, Potchefstroom University, 1994-1997, M.S. dissertation: The influence of long-term treatment with HPTP (the tetrahydropyridineanalogue of haloperidol)in baboons. " Stefanus Steyn, Potchefstroom University, 1995-1999, Ph.D. dissertation: Mitochondrial respiration in the presence of haloperidol, MPTP and some of their major metabolites. * James P. Dheyongera, University of the North, 1994-2001, Ph.D. dissertation: Synthesis and biological evaluation of some thioacridones related to the acroncynine alkaloid. * Jacobus P. Petzer, Potchefstroom University, 2001-2002, Ph.D. dissertation: The synthesis and evaluation of caffeine analogs as dual adenosine A2A receptorantagonists and inhibitorsof monoamine oxidase B. * Izel Fourie, North West University, 2001-2004, Ph.D. dissertation: Influence of tobacco smoke constituents on human placental monoamine oxidase A (MAO-A) activity vs. human blood platelet MAO-B activity. * Nusrat Motlekar, Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences & School of Pharmacy, Amarillo, TX, 2002- 2003, Laboratory Rotations. * Werner J. Geldenhuys, North West University, 2001-2004, Ph.D. dissertation: BiologicalActivity Profiles of Selected Polycyclic Cage Amines.

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" Ghia Robbertse, North West University, 2002-2005, Ph.D. dissertation: Smoking and Brain Dopamine Neurochemistry. * Erika Grobler, North West University, 2003-2005, M.Sc. dissertation: The influence of polycyclic amines on calcium homeostasis in neuronalcells. " Werner J. Geldenhuys, Ph.D., Postdoctoral Associate, Texas Tech University Health Sciences Center, on an Institue for Healthy Aging/Garrison Institute on Aging grant. * Julie Gaasch, Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences & School of Pharmacy, Amarillo, TX, 2005- 2006, Ph.D. dissertation: Iron overload toxicity in central nervous system associated cells and its attenuation by calcium channel blockers. * Lois-May Bezuidenhout, North West University, 2004-2007, M.Sc. dissertation: Triquinylamines as regulators of calcium homeostasis of neuronalcells. " Lois-May Bezuidenhout, North West University, 2007-2012, Ph.D. dissertation: Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration. Conducted research at NEOMED. Dissertation/Graduate Committees Served on (Advisory Committee Member, External/internal Examiner) (month and year = study completed and degree conferred; year only denotes ongoing study): " Chairperson, M.Sc., Wilna Liebenberg, Pharmaceutical Chemistry (Potchefstroom University), graduated June 1986. * Member, M.Sc., Willem C. Durand, Pharmaceutical Chemistry (Potchefstroom University), graduated June 1987. * Chairperson, M.Sc., Riaan Bornman, Pharmaceutical Chemistry (Potchefstroom University), graduated January 1988. * Chairperson, M.Sc., Daniel P. Prinsloo, Pharmaceutical Chemistry (Potchefstroom University), graduated January 1988. * Member, M.Sc., Rudolf J. De Bruin, Physiology (Potchefstroom University), graduated January 1989. * Chairperson, M.Sc., Petro Snyman, Pharmaceutical Chemistry (Potchefstroom University), graduated January 1989. * Chairperson, Ph.D., Wilna Liebenberg, Pharmaceutical Chemistry (Potchefstroom University), graduated June 1989. * Chairperson, M.Sc., Karin Swanepoel, Pharmaceutical Chemistry (Potchefstroom University), graduated January 1990. * Member, Ph.D., H.M. Roos, Chemistry (University of Pretoria), January 1990. * Chairperson, M.Sc., Gisella Dockendolf, Pharmaceutical Chemistry (Potchefstroom University), graduated June 1992. * Member, M.Pharm., Andries J. Van Zyl, Radiopharmacy and pharmacology (Potchefstroom University), graduated December 1992. * Member, M.Sc., Annemarie Joubert, Pharmaceutical Chemistry (Potchefstroom University), graduated June 1993.

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* Member, M.Pharm., Jaqueline D. Van Schoor, Pharmacology (Potchefstroom University), graduated December 1993. " Member, Ph.D., Darryl W. Eyles, Medicine (University of Queensland), graduated May 1995. * Co-Chairperson, M.Sc., Adolf Mattheus, Pharmaceutics (Potchefstroom University), graduated January 1996. " Member, M.Pharm., Daniel A. Shalala, Pharmacy Practice (Potchefstroom University), graduated January 1996. * Member, M.Pharm., Johan C. Lamprecht, Pharmacy Practice (Potchefstroom University), graduated January 1996. * Member, M.Sc., George K. Cloete, Pharmaceutical Chemistry (University of Port Elizabeth), graduated March 1996. * Chairperson, M.Sc., Ron6l Keeve, Pharmaceutical Chemistry (Potchefstroom University), graduated October 1996. " Chairperson, Ph.D., Sarel F. Malan, Pharmaceutical Chemistry (Potchefstroom University), graduated July 1997. * Chairperson, Ph.D., Gisella Dockendolf, Pharmaceutical Chemistry (Potchefstroom University), graduated April 1998. * Chairperson, M.Sc., Ilze Van den Heever, Microbiology (Potchefstroom University), graduated April 1999. * Member, M.S., Ethan R. Freeborn, Entomology/neuropathology (Virginia Tech), graduated July 1999. " Chairperson, Ph.D., Stefan J. Steyn, Pharmaceutical Chemistry (Potchefstroom University), graduated September 1999. * Member, M.Sc., J. Daniel M. Odendaal, Biochemistry (Potchefstroom University), graduated September 1999. * Member, M.S., Julian T. Pittman, Veterinary Medical Sciences/ neurochemistry (VA-MD Regional College of Veterinary Medicine, Virginia Tech), graduated October 1999. " Chairperson, Ph.D., J. Patrick Dheyongera, Pharmaceutical Chemistry (Potchefstroom University), graduated May 2001. * Member, Ph.D., Christiane Massicotte, Veterinary Medicine/neurochemistry (VA-MD Regional College of Veterinary Medicine, Virginia Tech), graduated October 2001. " Member, M.Sc., Meshele H. Grobler, Biochemistry (Potchefstroom University), graduated October 2001. " Member, M.S., Celia Dodd, Veterinary Medical Sciences/Neurochemistry (VA-MD Regional College of Veterinary Medicine, Virginia Tech), 2001-2002. * Member, Ph.D., Jinghang Kou, Entomology/Neuroscience (Virginia Tech), 2002-2005. " Member, Ph.D., Jonathan Fox, Veterinary Medicine/Neurochemistry (VA-MD Regional College of Veterinary Medicine, Virginia Tech), graduated May 2002.

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* Member, M.Sc., Werner J. Geldenhuys, Pharmaceutical Chemistry (Potchefstroom University), graduated May 2002. * Chairperson, Ph.D., Jacobus P. Petzer, Pharmaceutical Chemistry (Potchefstroom University), graduated September 2002. * Member, M.Sc., Johannes Van der Merwe, Pharmaceutical Chemistry (Potchefstroom University), graduated December 2002. * Member, M.Sc., Nicolette Heyer, Pharmaceutical Chemistry (Potchefstroom University), graduated December 2002. " Co-Chairperson, Ph.D., Izel Fourie, Pharmaceutical Chemistry (North West University), graduated May, 2004. * Member, Ph.D., Julie Gaasch, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), 2004-2005. * Co-Chairperson, Ph.D., Werner J. Geldenhuys, Pharmaceutical Chemistry (North West University), graduated May 2005. * Co-Chairperson, M.Sc., Erika Grobler, Pharmaceutical Chemistry (North West University), graduated May 2005. * Member, Ph.D., Ragini Vuppugalla, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated May 2005. * Member, Ph.D., Anjaneya Chimalakonda, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated May 2005. * Chairperson, Ph.D., Ghia Robbertse, Pharmaceutical Chemistry (North West University), graduated September 2005. * Member, Ph.D., Young Tak Ko, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated May 2006. * Member, Ph.D., Nusrat Motlekar, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated February 2006. * Member, Ph.D., Jagan Mohan Reddy Parepally, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated May 2006. * Member, M.Sc., E.E. Jordaan, Physiology, (North West University), graduated August 2006. " Chairperson, Ph.D., Julie Gaasch, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated October 2006. * Member, Ph.D., Cornelia Kiewert, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated October 2006. * Member, Ph.D., Jennifer Paulson, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated May 2007.

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* Co-Chairperson, M.Sc., Lois-May Bezuidenhout, Pharmaceutical Chemistry, (North West University), graduated September 2007. * Moderator, Ph.D. defense, Lisa Noelle Cooper, Biological Anthropology, (NEOMED and Kent State University, Biomedical Sciences Graduate Program), graduated September 18, 2009. " Moderator, Ph.D. defense, Ashleigh Elizabeth Nugent, Cellular and Molecular Biology, (NEOMED and Kent State University, Biomedical Sciences Graduate Program), graduated March 25, 2010. * Member, Ph.D., Vamshi Manda, Pharmaceutical Sciences, (Texas Tech University Health Sciences Center School of Pharmacy), graduated August 2010. * Member, M.S., Kristen (Kristy) Malacos, Pharmacology, (NEOMED and Kent State University, Biomedical Sciences Graduate Program), graduated May 4, 2012. " Chairperson, Ph.D., Lois-May Bezuidenhout, Pharmaceutical Chemistry, (North West University), graduated May 25, 2012. " Member, Ph.D., Prabha S. Awale, Pharmacology, (NEOMED and Kent State University, Biomedical Sciences Graduate Program), graduated August 11, 2012. * Member, M.S., Phani Talasila, Cellular and Molecular Biology, (NEOMED and Kent State University, Biomedical Sciences Graduate Program), successfully defended August 30, 2012. * Member, Ph.D., C.P.S Badenhorst, Biochemistry, (North West University), 2013. Undergraduate/Predoctoral Student Mentoring * Scholarship mentor for Patricia McHazlett (clerkship student in my laboratory) - named as Merck/AFAR scholarship recipient, Texas Tech University HSC School of Pharmacy, 2004. " Women's Health Research Institute funded Summer Interns 2004 and 2005: Krissandra Pope, Skyler McLaurin, Texas Tech University HSC School of Pharmacy. " Scholarship mentor for Julie Gaasch, 2004-2005 NACDS-AFPE Pre-Doctoral Fellow in Pharmaceutical Science, Texas Tech University HSC School of Pharmacy. Appointed Faculty Member, West Texas A&M University, Canyon, Texas. " Research Mentor for David Lerner (2007 - M1, 2008 - M2) NEOMED. Admitted to Neurology Residency, Duke University. " P3 Research Elective mentor for Kristin Lehotsky and Susan Kidd, NEOMED, Spring 2010. * P3 Research Elective mentor for Andreja Gnjatic, NEOMED, Spring 2012. Chairperson of Congress Organizing Committees (Congress Convenor) or Invited Symposium Chairmanship * 12th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, April 18-20, 1991, Potchefstroom, South Africa.

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" ChemPharm '92: "Chemistry in the Pharmaceutical Industry: Basics, Development and Concepts", November 5-6, 1992, Johannesburg, South Africa. * Symposium 5: Parkinson's Disease and Movement Disorders. IV. Neurotoxicity .Society Meeting: Neurochemical Mechanisms of Neurodegenerative Disorders. Arica, Chile, April 24-26, 2009.

LIST OF PEER-REVIEWED PUBLICATIONS, PATENTS, BOOK CHAPTERS 1. Publications Published, Accepted or Submitted for Publication 1.1 Dekker, T.G., Van der Schyf, C.J., Kruger, G.J., and Van Rooyen, P.H. Resolution of 1 -methylpentacyclo[5.4.0.0 2.6.03,10.0s5 9]undecane-8, 11 -dione. South African Journalof Chemistry, 1983, 36: 59 - 64. 1.2 Dekker, T.G., Fourie, T.G., Snyckers, F.O., and Van der Schyf, C.J. Studies of South African medicinal plants. Part 2. Caespitin, a new phloroglucinol derivative with antimicrobial properties from Helichrysum caespititium. South African Journalof Chemistry, 1983, 36: 114 - 116. 1.3 Dekker, T.G., Fourie, T.G., Naude, M.U., Snyckers, F.O., and Van der Schyf, C.J. A convenient preparation of alkenylated acylphloroglucinols. South African Journalof Chemistry, 1984, 37: 74 - 75. 1.4. Dekker, T.G., Fourie, T.G., Snyckers, F.O., and Van der Schyf, C.J. 13C NMR spectra of 3-substituted phlorophenone compounds. Journal of Organic Magnetic Resonance, 1984, 22: 607-608. 1.5 Squier, G.J., Van der Schyf, C.J., Oliver, D.W., and Venter, D.P. Comparative x- and 3- adrenoceptor activity of 2- and 6- ring chlorinated noradrenaline analogues. Artzneimittel Forschung/Drug Research, 1986, 36: 457-460. 1.6. Van der Schyf, C.J., Dekker, T.G., and Snyckers, F.O. Pharmacological studies of two novel polycyclic derivatives of ephedrine. Archiv der Pharmazie, 1986, 319: 409-415. 1.7. Squier, G.J., Van der Schyf, C.J., Venter, D.P., Oliver, D.W., Van Rooyen, P.H., and Dillen, J.L.M. Ring chlorinated noradrenalines. Comparative molecular mechanics and pharmacological studies. European Journal of Medicinal Chemistry, 1986, 21: 213-217. 1.8 Van der Schyf, C.J., Squier, G.J., and Coetzee, W.A. Characterization of NGP 1-01, an aromatic polycyclic amine as a calcium antagonist. PharmacologicalResearch Communications, 1986, 18: 407-417. 1.9 Van der Schyf, C.J., Dekker, T.G., Fourie, T.G., and Snyckers, F.O. Synthesis and antimicrobial activity of a series of caespitin derivatives. AntimicrobialAgents & Chemotherapy, 1986, 30: 375-381. 1.10 Banijamali, A., Van der Schyf, C.J., and Makriyannis, A. Tetrahydrocannabinol interactions with model membranes. Journal of PharmaceuticalSciences, 1987, 76: S153-S153. 1.11 Banijamali, A.R., Charalambous, A., Van der Schyf, C.J., and Makriyannis, A. Specific deuteration of phenols and aromatic ethers using boron trifluoride and deuterium oxide. Journal of Labeled Compounds & Radiopharmaceuticals,1987, 24: 1479-1482.

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1.12 Banijamali, A.R., Abou-Taleb, N., Van der Schyf, C.J., Charalambous, A., and Makriyannis, A. Synthesis of deuterium labelled cannabinoids. Journalof Labeled Compounds & Radiopharmaceuticals,1988, 25: 73-82. 1.13 Dekker, T.G., Fourie, T.G., Matthee, E., Snyckers, F.O., Van der Schyf, C.J., Boeyens, J.C.A., and Denner, L. Studies on South African medicinal plants. Part 7. Rhinocerotinoic acid: a labdane diterpene with anti- inflammatory properties from Elytropappus Rhinocerotis. South African Journalof Chemistry, 1988, 41: 33-35. 1.14 Van der Schyf, C.J., Mavromoustakos, T., and Makriyannis, A. The conformation of (-)8(x and (-)811-hydroxy-A9-tetrahydrocannabinols and their interactions with model membranes. Life Sciences, 1988, 42: 2231- 2239. 1.15 Van der Walt, J.J., Van der Schyf, C.J., Van Rooyen, J.M., De Jager, J., and Van Aarde, M.N. Calcium current blockade in cardiac myocytes by NGP 1-01, an aromatic polycyclic amine. South African Journal of Science, 1988, 84: 448-450. 1.16 Van der Schyf, C.J., Liebenberg, W., Bornman, R., Dekker, T.G., Van Rooyen, P.H., Fourie, T.G., Matthee, E., and Snyckers, F.O. The polycyclic calcium antagonist, NGP 1-01, has an oxa, rather than an aza bird-cage structure: Evidence from NMR spectroscopy and the X-ray crystal structure. South African Journalof Chemistry, 1989, 42: 46-48. 1.17 Van der Schyf, C.J. Die behandeling van VIGS - Geneesmiddels en Vaksiene - Wat hou die Toekoms in? (In Afrikaans, English Title: "The treatment of AIDS - Drugs and Vaccines - What does the future hold?") Koers, 1990, 55: 317-328. 1.18 Van der Schyf, C.J., and Swanepoel, K. Natural products as drug templates: coriolin-like antimicrobial triquinane amines. Planta Medica, 1990, 56, 646-647. 1.19 Van der Schyf, C.J., Castagnoli, K., Usuki, E., Fouda, H., Rimoldi, J., and Castagnoli, N., Jr. Metabolic studies of haloperidol and its tetrahydropyridine analog in C57BL/6 mice. Chemical Research in Toxicology, 1994, 7: 281-285. 1.20 Liebenberg, W.; Van Rooyen, P.H., and Van der Schyf, C.J. The biological activity of two symmetric amine derivatives of the cis-syn-cis triquinane system. Pharmazie, 1996, 51, 20-24. 1.21 Van der Schyf, C.J., Dormehl, I.C., Oliver, D.W., Hugo, N., Keeve, R., Muller-Grtner, H.-W., Pond, S.M., and Castagnoli, N., Jr. Long-term treatment with the the tetrahydropyridine analog (HPTP) of haloperidol influences dopamine ligand binding in baboon brain. An 12 3 1- iodobenzamide (IBZM) SPECT study. Brain Research - Molecular Brain Research, 1996, 43, 251-258. 1.22 Brand, L., Oliver, D.W., Van der Schyf, C.J., Pond, S.M., and Castagnoli, N., Jr. Dopamine receptor binding of 4-(4-chlorophenyl)-1-[4-(4- fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridine (HPTP), an intermediate metabolite of haloperidol. Life Sciences, 1996, 59, 815-820. 1.23 Avent, K. M., Usuki, E., Eyles, D.W., Keeve, R., Van der Schyf, C.J., Castagnoli N., Jr., and Pond, S.M. Haloperidol and its tetrahydropyridine

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derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboon. Life Sciences, 1996, 59, 1473-1,482. 1.24 Malan, S.F., Van den Heever, I., and Van der Schyf, C.J. Screening of polycyclic amines for calcium channel antagonism. Journal of PharmaceuticalMedicine, 1996, 6, 125-135. 1.25 Mienie, L.J., Bergh, J.J., Van Staden, E., Steyn, S.J., Pond, S.M., Castagnoli, N., Jr., and Van der Schyf, C.J. Metabolic defects caused by treatment with the tetrahydropyridine analog of haloperidol (HPTP), in baboons. Life Sciences, 1997, 61, 265-272. 1.26 Oliver, D.W., Dormehl, I.C, Van der Schyf, C.J., Neumeyer, J.L, Hugo, N., Keeve, R., Rossouw, N.T., M1ller-Gtrtner, H,-W., and Castagnoli, N., Jr. Effect of the haloperidol tetrahydropyridine metabolite 4-(4-chlorophenyl)- 1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridine on dopamine receptor and transporter binding: a nonhuman primate 1231-iodobenzamide and 2j3-carbomethoxy-3j3-(4-iodophenyl)tropane single photon emission computed tomographic study. Arzneimittel Forschung/Drug Research, 1997, 47, 692-699. 1.27 Avent, K.M., Riker, R.R., Fraser, G.L., Van der Schyf, C.J., Usuki, E., and Pond, S.M. Metabolism of haloperidol to pyridinium species in patients receiving high doses intravenously: is HPTP an intermediate? Life Sciences, 1997, 61, 2383-2390. 1.28 Ooms, F., Wouters, J., Durant, F., Castagnoli, N., Jr., Van't Land, C., Dockendolf, G., Glass, T., and Van der Schyf, C.J. Conformational distribution of the potentially neurotoxic metabolite of haloperidol, HPP÷, by nuclear magnetic resonance spectroscopy, X-ray crystallography and molecular dynamics simulations. Journal of the Chemical Society, Perkin Trans. 2,1997, 2627-2632. 1.29 Banijamali, A.R., Van der Schyf, C.J., and Makriyannis, A. Addition and elimination of HCI to tetrahydrocannabinol isomers. A method for the preparation of stereospecifically 2H labeled cannabinoids. Journal of Labelled Compounds & Radiopharmaceuticals,1998, 41, 121-130. 1.30 Usuki, E., Van der Schyf, C.J., and Castagnoli, N., Jr. Metabolism of haloperidol and its tetrahydropyridine dehydration product HPTP. Drug Metabolism Reviews, 1998, 30, 809-826. 1.31 Malan, S.F, Dockendolf, G, Van der Walt, J.J., Van Rooyen, J.M., and Van der Schyf, C.J. Enantiomeric resolution of the calcium channel antagonist 8-benzylamino-8, 11 -oxapentacyclo[5.4.0.02'6 .03 ',1 .05',]unde-cane (NGP 1- 01). Pharmazie, 1998, 53, 859-862. 1.32 McRichie, D.A., Cartwright, H., Pond, S.M., Van der Schyf, C.J., Castagnoli, N., Jr. Van der Nest, D.G., and Halliday, G.M. The midbrain dopaminergic cell groups in the baboon Papio ursinus. Brain Research Bulletin, 1998, 47, 611-623. 1.33 Castagnoli, N., Jr., Castagnoli, K., Van der Schyf, C.J., Usuki, E., Igarashi, K., Steyn, S.J., and Riker, R.R. Enzyme catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins. Polish Journal of Pharmacology, 1999, 51, 31-38. 1.34 Halliday, G.M., Pond, S.M., McRichie, D.A., Castagnoli, N., Jr., and Van der Schyf, C.J. Clinical and neuropathological abnormalities in baboons

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treated with HPTP, the tetrahydropyridine analog of haloperidol. Experimental Neurology, 1999, 158, 155-163. 1.35 Mienie, L.J., Bergh, J.J., Bloomquist, J.R., Castagnoli, N., Jr., Steyn, S.J., and Van der Schyf, C.J. p-Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Life Sciences, 1999, 65, 535-542. 1.36 Liu, X., Zang, L., Van der Schyf, C.J., Castagnoli, K., and N. Castagnoli, Jr. Studies on the pyrrolinone metabolites derived from the tobacco alkaloid 1-methyl-2-(3-pyridyl)pyrrole (,l-nicotyrine). Chemical Research in Toxicology, 1999, 12, 508-512 (featured on journal cover). 1.37 Inoue, H., Castagnoli, K., Van der Schyf, C.J., Mabic, S., Igarashi, K., and Castagnoli, N., Jr. Species dependent differences in the monoamine oxidase A and B catalyzed oxidation of various C-4 substituted 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridinyl derivatives. Journal of Pharmacology & Experimental Therapeutics, 1999, 291, 856-864. 1.38 Malan, S.F., Van der Walt, J.J., and Van der Schyf, C.J. Structure-activity relationships of polycyclic aromatic amines with calcium channel blocking activity. Archiv der Pharmazie: Pharmaceutical & Medicinal Chemistry, 2000, 333, 10-16. 1.39 Eyles, D.W., Pond, S.M., Van der Schyf, C.J., and Halliday G.M. Mitochondrial ultrastructure and density in a primate model of persistent tardive dyskinesia. Life Sciences, 2000, 66, 1345-1350. 1.40 Van der Schyf, C.J., Castagnoli, K., Palmer, S., Hazelwood, L., and Castagnoli, N., Jr. Melatonin fails to protect against long-term MPTP- induced dopamine depletion in mouse striatum. Neurotoxicity Research, 2000, 1, 261-269.

1.41 3Steyn, S.J., Mienie, L.J., and Van der Schyf, C.J. ,)-Oxidation of [9,10(n)- H]palmitate by human leukocytes: a simple in situ assay to assess mitochondrial toxicity in the presence of toxins. Toxicology Mechanisms and Methods, 2000, 10, 99-109. 1.42 Petzer, J.P., Bergh, J.J., Mienie, Castagnoli, N., Jr., and Van der Schyf, C.J. Metabolic defects caused by MPTP and HPTP (the tetrahydropyridine analog of haloperidol), in rats. Life Sciences, 2000, 66, 1949-1954. 1.43 Liu, X., Castagnoli, K., Van der Schyf, C.J., and Castagnoli, N., Jr. Studies on the in vivo biotransformation of the tobacco alkaloid frnicotyrine. Chemical Research in Toxicology, 2000, 13, 336-341. 1.44 Ooms, F., Delvosal, S., Wouters, J., Durant, F., Dockendolf, G., Van't Land, C., Glass, T., Castagnoli, N., Jr., and Van der Schyf, C.J. Empirical and molecular modeling study on RHPP+, an abundant and potentially neurotoxic metabolite of haloperidol. Journal of the Chemical Society, Perkin Trans. 2, 2000, 1781-1787. 1.45 Ooms, F., Norberg, B., Isin, E.M., Castagnoli, N., Jr., Van der Schyf, C.J., and Wouters, J. 7-Nitroindazole. Acta Crystallographica,2000, C56, e474- 475. 1.46 Liebenberg, W., Van der Walt, J.J., and Van der Schyf, C.J. Effects of derivatives of NGP 1-01, a putative calcium antagonist, on electrically stimulated guinea-pig papillary muscle. Pharmazie, 2000, 555, 833-836.

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1.47 Castagnoli, K.P. Steyn, S.J., Petzer, J.P., Van der Schyf, C.J., and Castagnoli, N., Jr. Neuroprotection in the MPTP parkinsonian C57BL/6 mouse model by a compound isolated from tobacco. Chemical Research in Toxicology, 2001, 14, 523-527. 1.48 Castagnoli, K., Steyn, S.J., Magnin, G., Van der Schyf, C.J., Fourie, I., Khalil A., and Castagnoli, N., Jr. Studies on the interactions of tobacco leaf and tobacco smoke constituents and monoamine oxidase. Neurotoxicity Research, 2002, 4, 151-160. 1.49 Usuki, E., Bloomquist, J.R., Freeborn, E., Castagnoli, K., Van der Schyf, C.J., and Castagnoli, N., Jr. Metabolic studies on haloperidol and its tetrahydropyridinyl dehydration product (HPTP) in C57B1/6 mouse brain preparations. Neurotoxicity Research, 2002, 4, 51-58. 1.50 Chen, J.F., Steyn, S., Staal, R., Petzer, J.P., Xu, K., Van der Schyf, C.J., Castagnoli, K., Sonsalla, P.K., Castagnoli, N., Jr., and Schwarzschild, M.A. 8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism. Journal of Biological Chemistry, 2002, 277, 36040-36044. 1.51 Geldenhuys, W.J., Van der Schyf, C.J., and Malan, S.F. Screening of novel pentacyclo-undecylamines for neuroprotective activity. European Journalof Pharmacology,2003, 458, 73-79. 1.52 Ooms, F., Frederick, R., Durant, F., Petzer, J.P., Castagnoli, N., Jr., Van der Schyf, C.J., and Wouters, J. Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-indeno[1,2-c]pyridazin-5-one derivative. Bioorganic & Medicinal Chemistry Letters, 2003, 13, 69-73. 1.53 Petzer, J.P., Steyn, S., Castagnoli, K.P., Chen, J.-F., Schwarzschild, M.A., Van der Schyf, C.J., and Castagnoli, N., Jr. Inhibition of monoamine oxidase B by selective adenosine A2A receptor antagonists. Bioorganic & Medicinal Chemistry, 2003, 11, 1299-1310. BMC "Most Cited Paper" Award for the Period 2003-2006. 1.54 Castagnoli, K., Petzer, J.P., Steyn, S.J., Van der Schyf, C.J., and Castagnoli, N., Jr. Inhibition of human MAO-A and MAO-B by a compound isolated from flue-cured tobacco leaves and its neuroprotective properties in the MPTP mouse model of neurodegeneration. Inflammopharmacology, 2003, 11, 183-188. 1.55 Malan, S.F., Dyason, K., Wagenaar, B., Van der Walt, J.J., and Van der Schyf, C.J. The structure and ion channel activity of 6-benzylamino-3- hydroxyhexacyclo[6.5.0.0 3,7.04,12.05,10.0 9,13]tridecane. Archiv der Pharmazie:Pharmaceutical & Medicinal Chemistry, 2003, 336,127-133. 1.56 Castagnoli, N. Jr., Petzer, J.P., Steyn, S., Castagnoli, K., Chen, J.-F., Schwarzschild, M.A., and Van der Schyf, C.J. Monoamine oxidase B inhibition and neuroprotection: Studies on selective adenosine A2A receptor antagonists. Neurology, 2003, 61 (Suppl. 6), S62-S68. 1.57 Geldenhuys, W.J., Malan, S.F. Murugesan, T., Van der Schyf, C.J., and Bloomquist, J.R. Synthesis and biological evaluation of pentacyclo[5.4.0.02 '6 .0' 1 .005,9] undecane derivatives as potential therapeutic agents in Parkinson's disease. Bioorganic & Medicinal Chemistry, 2004, 12,1799-1806.

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1.58 Geldenhuys, W.J., Lockman, P.R., McAfee, J.H., Fitzpatrick, K.T., Van der Schyf, C.J., and Allen, D.D. Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry Letters, 2004, 14, 3085-3092. 1.59 Loots, Du T., Mienie, L.J., Bergh, J.J., and Van der Schyf, C.J. Acetyl-L- carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat. Life Sciences, 2004, 75, 1243-1253. 1.60 Van der Schyf, C.J., and Mabic, S. Electron-induced (El) mass fragmentation is directed by intramolecular H-bonding in two isomeric benzodipyran systems. Molecules, 2004, 9, 830-841, http://www.mdpi.orqlg molecules/papers/91000830.pdf. 1.61 Steyn, S.J., Pieterse, D.J., Mienie, L.J., and Van der Schyf, C.J. Measurement of mitochondrial respiration in permeabilized murine neuroblastoma (N-2a) cells, a simple and rapid in situ assay to investigate mitochondrial toxins. Journal of Biochemical and Biophysical Methods, 2005, 62, 25-40. 1.62 Geldenhuys, W.J., Malan, S.F., Bloomquist, J.R., Marchand, A.P., and Van der Schyf, C.J. Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: A focus on pentacycloundecane derivatives. Medicinal Research Reviews, 2005, 25, 21-48 (featured on journal cover). 1.63 Dheyongera, J.P., Geldenhuys, W.J., Dekker, T.G., and Van der Schyf, C.J. Synthesis, biological evaluation and molecular modeling of novel thioacridone derivatives related to the anti-cancer alkaloid acronycine. Bioorganic & Medicinal Chemistry, 2005, 13, 689-698. 1.64 Dheyongera, J.P., Geldenhuys, W., Dekker, T.G., Matsabisa M.G., and Van der Schyf, C.J. Antimalarial activity of thioacridone compounds related to the acronycine alkaloid. Bioorganic& Medicinal Chemistry, 2005, 13,1653-1659. 1.65 Massicotte, C., Knight, K., Van der Schyf, C.J., Jortner, B.S. and Ehrich, M. Effects of organophosphorus compounds on ATP production in cultured cells. Neurotoxicity Research, 2005, 7, 203-217. 1.66 Lockman, P.R., Van der Schyf, C.J., Abbruscato, T.J., and Allen, D.D. Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine. Journal of Neurochemistry, 2005, 94, 37-44. 1.67 Geldenhuys, W.J., Lockman, P.R., Nguyen, T., Van der Schyf, C.J., Crooks, P.A., Dwoskin, L.P., and Allen, D.D. 3D-QSAR study of bis- azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter. Bioorganic & Medicinal Chemistry, 2005, 13, 4253- 4261. 1.68 Mdzinarishvili, A., Geldenhuys, W.J., Abbruscato, T.J., Bickel, U., Klein, J., and Van der Schyf, C.J. NGP1-01, a dual-mechanism calcium channel blocker, is neuroprotective in focal ischemia. Neuroscience Letters, 2005, 383, 49-53. 1.69 Lockman, P.R., McAfee, G., Geldenhuys, W.J., Van der Schyf, C.J., Abbruscato, T.J., and Allen, D.D. Brain uptake kinetics of nicotine and

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cotinine after chronic nicotine exposure. Journal of Pharmacology & Experimental Therapeutics,2005, 314, 636-642. 1.70 Fr6deric, R., Ooms, F., Castagnoli, N., Jr., Petzer, J.P., Feng. J.-F., Schwarzschild, M.A., Van der Schyf, C.J., and Wouters, J. (E)-8-(3- chlorostyryl)-1,3-7-trimethylxanthine, a caffeinyl derivative acting both as antagonist of adenosine A2A receptors and inhibitor of MAO-B. Acta Crystallographica,2005, C61, 531-532. 1.71 Paulson, J.R., Roder, K.E., McAfee, G., Allen, D.D., Van der Schyf, C.J., and Abbruscato, T.J. Tobacco smoke chemicals attenuate brain-to-blood potassium transport mediated by the Na,K,2CI-cotransporter during hypoxia-reoxygenation. Joumal of Pharmacology & Experimental Therapeutics,2006, 316, 248-254. 1.72 Grobler, E., Grobler, A., Van der Schyf, C.J., and Malan, S.F. Effect of Polycyclic Cage Amines on the Transmembrane Potential of Neuronal Cells. Bioorganic& Medicinal Chemistry, 2006, 14,1176-1181. 1.73 Geldenhuys, W.J., Gaasch, K.E., Watson, M., Allen, D.D., and Van der Schyf, C.J. Optimizing the use of open-source software applications in drug discovery. Drug Discovery Today, 2006, 11,127-132. Reached No. 12 on Science Direct's "Top 25 Hottest Articles". 1.74 Kiewert, C., Hartmann, J., Stoll, J., Thekkumkara, T., Van der Schyf, C.J.,* and Klein, J., NGP1-01 is a brain permeable dual blocker of neuronal voltage- and ligand-operated calcium channels. Neurochemical Research, 2006, 31, 395-399. 1.75 Lockman, P.R., Gaasch, J., McAfee, G., Abbruscato, T.J., Van der Schyf, C.J., and Allen, D.D. Nicotine exposure does not alter plasma to brain choline transfer. Neurochemical Research, 2006, 31, 503-508. 1.76 Fr6d6rick, R., Dumont, W., Ooms, F., Aschenbach, L., Van der Schyf, C.J., Castagnoli, N., Jr., Wouters, J., and Krief, A. Synthesis, structural reassignment and biological activity of type B MAO inhibitors based on the 5H-indeno-[1,2-c]pyridazin-5-one core. Journal of Medicinal Chemistry, 2006, 49, 3743 - 3747. 1.77 Van der Schyf, C.J., Geldenhuys, W.J., and Youdim, M.B.H. Multifunctional neuroprotective drugs for the treatment of cognitive and movement impairment disorders, including Alzheimer's and Parkinson's diseases. Drugs of the Future, 2006, 31, 447-460. 1.78 Van der Schyf, C.J., Gal, S., Geldenhuys, W.J., and Youdim, M.B.H. Multifunctional neuroprotective drugs targeting monoamine oxidase inhibition, iron chelation, adenosine receptors, cholinergic, and glutamatergic action for neurodegenerative diseases. Expert Opinion on InvestigationalDrugs, 2006, 15, 873-886. 1.79 Van der Schyf, C.J., Geldenhuys, W.J., and Youdim, M.B.H. Multifunctional Drugs with Different CNS Targets for Neuropsychiatric Disorders. Journal of Neurochemistry, 2006, 99, 1033-1048. 1.80 Kumar, V., Mdzinarishvili, A., Kiewert, C., Abbruscato, T., Bickel, U., Van der Schyf, C.J., and Klein, J. NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's wort. Journal of Pharmacological Sciences, 2006, 102, 47-54.

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1.81 Geldenhuys, W.J., and Van der Schyf, C.J. Triquinane-based compounds as possible serotonin 5-HT 6 receptor antagonists for the treatment of Alzheimer's Disease. Medical Hypotheses, 2007, 68, 81-86. 1.82 Geldenhuys, W.J., Hayes, M., Malan, S.F., Van der Schyf, C.J., and Allen, D.D. Receptor surface models in the classroom. Introducing molecular modeling to students in a 3D world. Journalof Chemical Education, 2007, 84, 979-982. 1.83 Geldenhuys, W.J., Malan, S.F., Bloomquist, J.R., and Van der Schyf, C.J. Structure-activity Relationships of Pentacycloundecylamines at the N- Methyl-D-Aspartate Receptor. Bioorganic and Medicinal Chemistry, 2007, 15,1525-1532. 1.84 Gaasch, J.A., Lockman, P.R., Geldenhuys, W.J., Allen, D.D., and Van der Schyf, C.J. Brain Iron Toxicity: Differential responses of astrocytes, neurons, and endothelial cells. Neurochemical Research, 2007, 32, 1196- 1208. 1.85 Youdim, M.B.H., and Van der Schyf, C.J., Magic bullets or novel multimodal drugs with various targets for Parkinson's Disease? Nature Reviews Drug Discovery, 2007, 6, iii-vi. 1.86 Van der Schyf, C.J., Geldenhuys, W.J., and Youdim, M.B.H. Multifunctional neuroprotective-neurorescue drugs for Parkinson's Disease. Future Neurology, 2007, 2, 411-423. 1.87 Gaasch, J.A., Geldenhuys, W.J., Lockman, P.R., Allen, D.D., and Van der Schyf, C.J. Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures. Neurochemical Research, 2007, 32, 1686-1693. 1.88 Van der Schyf, C.J., Mandel, S., Geldenhuys, W.J., Amit, T., Avramovich, Y., Zheng, H., Fridkin, M., Gal, S., Weinreb, 0., Bar-Am, 0., Sagi, Y., and Youdim, M.B.H. Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties. Current Alzheimer Research, 2007, 4, 522-536. 1.89 Youdim, M.B.H., Geldenhuys, W.J., and Van der Schyf, C.J. Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease? Parkinsonism and Related Disorders, 2007, 13, S281-5291. 1.90 Hau, J., Mdzinarishvili, A., Abbruscato, T.J., Klein, J., Geldenhuys, W.J., Van der Schyf, C.J., and Bickel U. Neuroprotection in mice by NGP1-01 after transient focal brain ischemia. Brain Research, 2008, 1196, 113-120.

1.91 Geldenhuys, W.J., and Van der Schyf, C.J. Serotonin 5-HT 6 receptor antagonists for the treatment of Alzheimer's disease. Current Topics in Medicinal Chemistry, 2008, 8,1035-1048. 1.92 Petzer, J.P., Castagnoli, N. Jr., Schwarzschild, M.A., Chen, J-F., and Van der Schyf, C.J. Dual-Target-Directed Drugs that Block Monoamine Oxidase B and Adenosine A2A Receptors for Parkinson's Disease. Neurotherapeutics,2009, 6, 141-151.

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1.93 Van der Schyf, C.J. and Geldenhuys, W.J. Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs? Neurotherapeutics,2009, 6, 175-186.

1.94 Geldenhuys, W.J. and Van der Schyf, C.J. The serotonin 5-HT 6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's Disease. Expert Review of Neurotherapeutics,2009, 9, 1073-1085. 1.95 Paulson, J.R., Yang, T., Selvaraj, P.K., Mdzinarishvili, A., Van der Schyf, C.J., Klein, J., Bickel, U., and Abbruscato, T.J. Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions. Journalof Pharmacologyand Experimental Therapeutics, 2010, 332, 371-379. 1.96 Geldenhuys, W.J., Manda, V.K., Mittapalli, R.K., Van der Schyf, C.J., Crooks, P.A., Dwoskin, L.P., Allen, D.D., and Lockman, P.R. Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter. Bioorganic and Medicinal Chemistry Letters, 2010, 20, 870-877. 1.97 Darvesh, A., Carroll, R.T., Bishayee, A., Geldenhuys, W.J. and Van der Schyf, C.J. Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents. Expert Review of Neurotherapeutics, 2010, 10, 729-745. 1.98 Geldenhuys, W.J., Darvesh, A.S., Funk, M.O., Van der Schyf, C.J., and Carroll, R.T. Identification of novel monoamine oxidase-B Inhibitors by structure-based virtual screening. Bioorganic and Medicinal Chemistry Letters, 2010, 20, 5295-5298. 1.99 Terre'blanche, G., Heyer, N., Bergh, J.J., Mienie, L.J., Van der Schyf, C.J., and Harvey, B.H. The Styrene Metabolite, Phenylglyoxylic Acid, Induces Striatal-Motor Toxicity in the Rat: Influence of Dose Escalation/Reduction over Time. Neurotoxicity Research, 2011, 20, 97-101. 1.100 Darvesh, A.S., Carroll, R.T., Geldenhuys, W.J., Gudelsky, G.A., Klein, J., Meshul, C.K., and Van der Schyf, C.J. In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery. Expert Opinion on Drug Discovery, 2011, 6,109-127. 1.101 Geldenhuys, W.J., and Van der Schyf, C.J. Role of serotonin in Alzheimer's disease: A new therapeutic target? CNS Drugs, 2011, 25, 765-781. 1.102 Geldenhuys, W.J., Youdim, M.B.H., Carroll, R.T., and Van der Schyf, C.J. The Emergence of Designed Multiple Ligands for Neurodegenerative Disorders. Progressin Neurobiology, 2011, 94, 347-359. 1.103 Geldenhuys, W.J., Ko, K.S., Stinnett, H., Van der Schyf, C.J., and Lim, M.H. Identification of Multifunctional Small Molecule-Based Reversible Monoamine Oxidase Inhibitors. Medicinal Chemistry Communications (MedChemComm), 2011, 2,1099-1103. 1.104 Lockman, J.A., Geldenhuys, W.J., Bohn, K.A., DeSilva, S.F., Allen, D.D. and Van der Schyf, C.J. Differential effect of nimodipine in attenuating

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iron-induced toxicity in brain- and blood-brain barrier-associated cell types. Neurochemical Research, 2012, 37, 134-142. 1.105 Geldenhuys, W.J., Funk, M.O., Van der Schyf, C.J. and Carroll, R.T. Scaffold hopping to identify novel monoamine oxidase B inhibitors. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 1380-1383. 1.106 Joubert, J., Geldenhuys, W.J., Van der Schyf, C.J., Oliver, D.W., Kruger, H.G., Govender, T. and Malan, S.F. Polycyclic cage structures as lipophilic scaffolds for neuro-active drugs. ChemMedChem, 2012, 7, 375-384. 1.107 Darvesh, A.S., Carroll, R.T., Bishayee, A., Novotny, N.A., Geldenhuys, W.J. and Van der Schyf, C.J. Curcumin and neurodegenerative diseases: a perspective. Expert Opinion on Investigational Drugs, 2012, 21, 1123- 1140. 1.108 AI-Baghdadi, 0., Prater, N.I., Van der Schyf, C.J., and Geldenhuys, W.J. Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's Disease. Bioorganic and Medicinal Chemistry Letters, 2012, 22, 7183- 7188. 1.109 Lockman, J.A., Geldenhuys, W.J., Jones-Higgins, M.R., Patrick, J.D., Allen, D.D., and Van der Schyf, C.J. NGP1-01, a multi-targeted polycyclic cage amine, attenuates brain endothelial cell death in iron overload conditions. Brain Research, 2012, 1489, 133-139. 1.110 Geldenhuys, W.J. and Van der Schyf, C.J. Designing drugs with multi- target activity: the next step in the treatment of neurodegenerative disorders. Expert Opinion on Drug Discovery, 2013, 8, 115-129. 1.111 Geldenhuys, W.J. and Van der Schyf, C.J. Rationally designed multi- targeted agents against neurodegenerative diseases. Current Medicinal Chemistry, 2013, 20,1662-1672. 1.112 Geldenhuys, W.J., Novotny, N.A., Malan, S.F., and Van der Schyf, C.J., 3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (0l) receptor. Bioorganic & Medicinal Chemistry Letters, 2013, 23, 1707- 1711. 1.113 Young, L.-M., Zeller, M., Geldenhuys, W.J., Malan, S.F., and Van der Schyf, C.J. Triquinane scaffolds: Shape and geometry as a function of saturation and bridgehead groups. Journal of Molecular Structure, 2013, 1045, 86-94. 1.114 Jogiraju, H., Zhou, X., Gobbun, A.L.P., Pedada, K.K., Geldenhuys, W.J., Van der Schyf, C.J., Crish, S.D., and Anderson, D.J. Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum. Journalof ChromatographyB, 2014, 963, 83-89. 1.115 Geldenhuys, W.J., Kochi, A., Lin, L., Sutariya, V., Dluzen, D.E., Van der Schyf, C.J., and Lim, M.-H. Methyl Yellow, a Potential Drug Scaffold for Parkinson's Disease. ChemBioChem, 2014, 15,1591-1598. 1.116 DeToma, A.S., Dengler-Crish, C.M., Deb, A., Braymer, J.J., Penner-Hahn, J.E., Van der Schyf, C.J., Lim, M.H., and Crish, S.D. Abnormal metal levels in the primary visual pathway of the DBA/2J mouse model of glaucoma. BioMetals, 2014, 27,1291-1301.

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1.117 Sorensen, I.F., Hudgins, L.J., Van der Schyf, C.J., Castagnoli, N., Jr., and Castagnoli, K. Cigarette smoking during pregnancy affects monoamine oxidase activity in human placenta and maternal blood platelets at term. Journalof PerinatalMedicine, 2015, under review. 1.118 Mienie, L.J., Erasmus, E., Knoll, D.P., Bester, C., Klopper, B., Hendriks, J.S., Bergh, J.J., Kleynhans, M.J., Van Zyl, G.J.:, and Van der Schyf, C.J. 3-Methylglutaconic aciduria Type I markers are significantly attenuated in a pediatric patient treated with an HMG-CoA reductase inhibitor. Neuropediatrics,2015, submitted. 1.119 Van Staden, E., Mienie, L.J., Bergh, J.J., and Van der Schyf, C.J. The urinary organic acid profiles of baboons and humans: a study in interprimate variation. Journal of Inherited Metabolic Diseases, 2015, submitted. 1.120 Petzer, J.P., Bergh, J.J., Mienie, Castagnoli, N., Jr., and Van der Schyf, C.J. The in vivo effect of deprenyl and ketoconazole on the metabolism of MPTP and HPTP (the tetrahydropyridine analog of haloperidol) respectively, in the rat. Life Sciences, 2015, submitted. 1.121 Van der Schyf, C.J., Lecatsas, G. and Greeff, A.S. Electron microscopy studies on the structural modifications of Staphylococcus aureus after treatment with caespitin and its 3-benzyl derivative. F.E.M.S. Letters, 2015, submitted. 1.122 Castagnoli, K., Van der Schyf, C.J. and Castagnoli, N., Jr. Monoamine oxidase B inhibition and neuroprotection. Polish Journalof Pharmacology, 2015, submitted. 1.123 Dockendolf, G and Van der Schyf, C.J. Molecular modeling of the binding of haloperidol and its tetrahydropyridine analog HPTP to the dopamine D2 receptor. Die Pharmazie, 2015, submitted. 1.124 Van der Schyf, C.J., Bergh, J.J., Van der Watt, J.G. and Dekker, T.G. Structure-activity relationship of phlorophenone derivatives with antimicrobial activity. Bioorganic & Medicinal Chemistry Letters, 2015, in preparation. 1.125 Van Rooyen, J.M. and Van der Schyf, C.J. In vitro protection against MPP+ toxicity in murine neuroblastoma (neuro 2A) cells by melatonin. Neuroscience Letters, 2015, in preparation. 1.126 Steyn, S.J., Castagnoli, K., Bunnell, L., Steyn, S., Van der Schyf, C.J. and Castagnoli, N., Jr. Spectrophotometric estimation of human platelet monoamine oxidase B activity in platelet rich plasma. Methods, 2015, in preparation. 2. Patents 2.1 Dekker, T.G., Fourie, T.G., Snyckers, F.O. and Van der Schyf, C.J. Phlorophenone derivatives and pharmaceutical compositions of phlorophenone compounds. South African Patent Number 81/4,480,02, Issued July 1981, 59 pp. S.A. Pat. J., Granted May 25, 1983. 2.2 Dekker, T.G., Fourie, T.G., Snyckers, F.O. and Van der Schyf, C.J. Phlorophenone derivatives and pharmaceutical compositions of phlorophenone compounds. European Patent Number E.P. 69,536 (Cl. Co7C49/845), Issued January 12, 1983. (C.A. 1983, 99 Abstract 99:5339)

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2.3 Fourie, T.G., Dekker, T.G., Snyckers, F.O. and Van der Schyf, C.J. Phlorophenone derivative, manufacture, use and pharmaceutical composition of phlorophenone compound. Japanese Patent Number: JP58015937, Issued January 1, 1983. 2.4 Dekker, T.G., Oliver, D.W., Snyckers, F.O. and Van der Schyf, C.J. Derivatives of pentacyclo undecanes, processes for preparing these compounds and pharmaceutical compositions thereof. European Patent Number, EP 112,936 (Cl. C07C87/40), Issued July 11, 1984 (CA 1985, 10, Abstract 102:24183). 2.5 Dekker, T.G., Oliver, D.W., Snyckers, F.O. and Van der Schyf, C.J. Pentacycloundecane derivatives, manufacture and medicine composition. Japanese Patent, Publication Number, JP59122431, Issued July 14, 1984 2.6 Fourie, T.G., Dekker, T.G., Snyckers, F.O. and Van der Schyf, C.J. Phlorophenone derivatives and pharmaceutical compositions of phlorophenone compounds, uses and pharmaceutical compositions of phlorophenone compounds. US Patent Number: 4,503,256, Issued March 5, 1985. 2.7 Dekker, T.G., Oliver, D.W., Snyckers, F.O. and Van der Schyf, C.J. Derivatives of pentacyclo undecanes, processes for preparing these compounds and pharmaceutical compositions thereof. US Patent Number: 4,622,430, Issued November 11, 1986, Abstract published in: General Pharmacology: The Vascular System, 18, Issue 4, 1987, Page iv. 2.8 Fourie, T.G., Dekker, T.G., Snyckers, F.O. and Van der Schyf, C.J. Phlorophenone derivatives and pharmaceutical compositions of phlorophenone compounds, uses and pharmaceutical compositions of phlorophenone compounds. Canadian Patent Number: 1,219,278, Issued March 7, 1987. 2.9 Fourie, T.G., Dekker, T.G., Snyckers, F.O. and Van der Schyf, C.J. Phlorophenone derivatives, processes for preparing such compounds, uses and pharmaceutical compositions of phlorophenone compounds. US Patent Number: 4,578,520, Abstract published in General Pharmacology: The Vascular System, 18, Issue 2, 1987, Page iv. 2.10 Dekker, T.G., Oliver, D.W., Snyckers, F.O. and Van der Schyf, C.J. Derivatives of pentacyclo undecanes, processes for preparing these compounds and pharmaceutical compositions thereof. Australian Patent Number: 570399/1988, Issued July 4, 1988. 2.11 Van der Schyf, C.J., Liebenberg, W., Van der Walt, J.J., Coetzee, W., Dekker T.G., Fourie T.G. and Snyckers F.O. Polycyclic compounds and pharmaceutical compositions thereof. South African Patent Number, SA 87/7609, 9, Issued October 5, 1988. 2.12 Van der Schyf, C.J., Liebenberg, W., Van der Walt, J.J., Coetzee, W., Dekker T.G., Fourie T.G. and Snyckers F.O. Polycyclic compounds and pharmaceutical compositions thereof. European Patent Number, EP 88309270.2-, Issued October 5, 1988. 2.13 Van der Schyf, C.J., Schiffer, R.B., Grammas, P., Wilson, M.R. Polycyclic compounds for use in treating glaucoma. US Provisional Patent Specification Application Number, 60/992,238, Filed December 4, 2007.

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2.14 Van der Schyf, C.J., Schiffer, R.B., Grammas, P., Wilson, M.R., Geldenhuys, W.J., Bezuidenhout, L.-M. Polycyclic compounds for use in treating ocular neurodegenerative diseases. US Patent Application Utility under 35 USC 111 (a), Application Number, 12328238, Filed December 4, 2008.

3. Book Chapters

3.1 NGP 1-01: Electrophysiological studies on a novel calcium antagonist. Van der Schyf, C.J., Squier, G.J. and Coetzee, W.A. in: Development of Drugs and Modern Medicines: J.W. Gorrod; G.G. Gibson and M. Mitchard, eds. 1986, Ellis Horwood, Chichister and VCH Verlagsgesellschaft, Weinheim, pp.174-178. 3.2 Interactions of cannabinoids with membranes. The role of cannabinoid stereochemistry and absolute configuration and the orientation of A9- THC in the membrane bilayer. Makriyannis, A., Banijamali, A.R., Jarrell, H. and Van der Schyf, C.J. in: Structure-Activity Relationships of the Cannabinoids, NIDA Research Monograph 79 - A RAUS Review Report: R.S. Rapaka and A. Makriyannis, eds. 1987, US Department of Health and Human Services, Rockville, MA, pp.123-133. 3.3 Calcium and potassium channel blockade by polycyclic amines. Van der Walt, J.J., Van der Schyf, C.J., Van Aarde, M.N., and Van Rooyen J.M. in: Ionic Currents and Ischemia (Varia Geneeskunde): Vereecke, J., Van Bogaert, P.P. and Verdonck, F., eds. 1990, Leuven University Press, Louvain, Belgium ISBN 90 6186 407 0, pp. 332. 3.4 Haloperidol-derived pyridiniurm metabolites. Structural and toxicological relationships to MPPt-like neurotoxins. Van der Schyf, C.J., Usuki, E. Pond, S.M., and Castagnoli, N., Jr. in: Contemporary Neuroscience; Highly Selective Neurotoxins: : Basic and clinical applications, Kostrzewa, R.M., Ph.D., ed. 1998, Humana Press Inc., Totowa, NJ, pp.195-210. 3.5 Inhibition of Monoamine Oxidase B by derivatives of pentacyclo[5.4.0.0 2' 6.03' 10 . 05'9 ]undecane. Geldenhuys, W.J., Klein, J., Malan, S.F., Bloomquist, J.R., Murugesan, T., and Van der Schyf, C.J. in: Proceedings of the 15th International Symposium on Microsomes and Drug Oxidations: Oesch F., Ph.D., ed. 2004, Medimont S.r.l., Bologna, Italy, pp. 77-81. 3.6 Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease. Van der Schyf, C.J., Geldenhuys, W.J., and Youdim, M.B.H. in: Pharmacological Mechanisms in Alzheimer's Therapeutics. A. Claudio Cuello, M.D., D.Sc., FRSC, ed. 2008, Springer Publishing, New York, NY, pp. 274-295. 3.7 Multifunctional drugs: Ladostigil, an anti-Alzheimer drug. Van der Schyf, C.J., Geldenhuys, W.J., and Youdim, M.B.H. in: Medicinal Chemistry of Alzheimer's Disease. Ana Martinez, Ph.D., ed. 2008, ISBN 978-81-7895- 342-7 Transworld Research Network, Kerala, India, pp. 1-20.

3.8 Multimodal Drugs and Their Future for Alzheimer's and Parkinson's Disease. Van der Schyf, C.J., and Geldenhuys, W.J. in: International Review of Neurobiology, Volume 100: Various Aspects of Monoamine Oxidase and Its Inhibitors. Edited by: Moussa B.H. Youdim and Peter

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Riederer, 2011, ISBN 10: 0-12-366857-3 Elsevier Limited. Oxford, United Kingdom, DOI: 10.1016/B978-0-12-386467-3.00006-6 pp. 107-125.

3.9 Discovery of Multi-Target Agents for Neurological Diseases via Ligand Design. Bolognesi, M.L., Melchiorre, C., Van der Schyf, C.J., and Youdim, M.B.H. Chapter 18 in: RSC Drug Discovery Series No. 21, Designing Multi-Target Drugs. Edited by: J. Richard Morphy and C. John Harris, 2012, Royal Society of Chemistry, United Kingdom, pp. 290-315.

3.10 ADME and Ocular Therapeutics: Retina. Van der Schyf, C.J., Crish, S.D., Crish, C., Inman, D., and Geldenhuys, W.J. Chapter 12 in: Methods in Pharmacology and Toxicology: Ocular Pharmacology and Toxicology: Edited by: Brian C. Gilger, 2014, ISBN 978-1-62703-744-0, DOI 10.1007/7653 2013 12, A product of Humana Press, Springer Science+Business Media New York, pp. 81-89.

4. Invited Book Reviews 4.1 Pharmacognosy. by G.E. Trease and W.C. Evans, 12th Ed., Bailli~re Tindall, London, 1983. Van der Schyf, C.J. for Geneeskunde 1984, 26: 189. 4.2 Handbook of Neurotoxicology, Vol 1 & 2 ISBN 0-89603-795-9 (Vol. 1), ISBN 0-89603-796-7 (Vol. 2): by Edward J. Massaro, Humana Press, Totowa, NJ, 2001. Van der Schyf, C.J. for Journal of Natural Products, 65(7); 1085-1086. 2002.

5. Published Peer-Reviewed Abstracts and Presentations Delivered to Specialist Audiences

5.1 Van der Schyf, C.J.*y Dekker, T.G.; Fourie, T.G. and Snyckers, F.O. Compositae as a source of antimicrobial compounds. Proceedings: 13th IUPAC International Symposium on the Chemistry of Natural Products, Pretoria, South Africa, 1982: Abstract No. A66. 5.2 Dekker T.G.; Van der Schyf, C.J.; Kruger, G.J. and Van Rooyen, P.H. The use of ephedrines in the resolution of intrinsically chiral ketones. Proceedings: 13th IUPAC International Symposium on the Chemistry of Natural Products, Pretoria, South Africa, 1982: Abstract No. B29. 5.3 Van der Schyf, C.J.*; Dekker, T.G. and Snyckers, F.O. QSAR of a series of antimicrobial compounds using molecular connectivity and the hydrophobic parameter, RM. Proceedings: 4th Congress of the Academy of Pharmaceutical Sciences of South Africa, Potchefstroom, South Africa, 1983. Abstract- S. Afr. Pharm. J., 1983, 50: 148. 5.4. Van der Schyf, C.J.*" Dekker, T.G.; Fourie, T.G. and Snyckers, F.O. Phlorophenone derivatives with antibacterial and antifungal properties. Proceedings: 4th Congress of the Academy of Pharmaceutical Sciences of South Africa, Potchefstroom, South Africa, 1983. Best poster presentation on congress. Abstract- S. Afr. Pharm. J., 1983, 50: 148. 5.5 Van der Schyf, C.J.*" Dekker, T.G. and Snyckers, F.O. NH1416, a novel anti-inflammatory agent with adrenal stimulating activity. Proceedings: Annual Congress of the Pharmacological and Physiological Societies of Southern Africa, Durban, South Africa, 1983. Abstract No. 5: p. 173-174.

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5.6 Van der Schyf, C.J.*," Dekker, T.G.; Snyckers, F.O.; Oliver, D.W and Barnard, B.J.H. Post-infection in vivo activity of polycyclic amine compounds against rabies virus. Proceedings: Annual Congress of the Pharmacological and Physiological Societies of Southern Africa, Durban, South Africa, 1983. Abstract No 6: p. 175-176. 5.7 Van der Schyf, C.J *" Squier, G.J. and Coetzee;-WA. Characterization of NGP-01, a novel aromatic polycyclic amine, as a calcium antagonist. Proceedings: Annual Congress of the Pharmacological and Physiological Societies of Southern Africa, Potchefstroom, South Africa, 1984. Abstract No P21 p. 118-119 and under Van der Schyf, C.J.*, Squier, G.J. and Coetzee, WA. NGP-01, a new calcium antagonist: Demonstyration of calcium antagonistic activity and related studies. S. Afr. J. Sci., 81, 338- 339, 1985. 5.8 Squier, G.J.; Van der Schyf, C.J.; Venter, D.P.; Oliver, D.W; Van Rooyen, P.H. and Dillen, J.L.M. Stereochemical aspects of chlorinated noradrenaline analogs. Proceedings: Annual Congress of the Pharmacological and Physiological Societies of Southern Africa, Potchefstroom, South Africa, 1984. Abstract No P21 p. 118-119 and S. Afr. J. Sci., 81, 338,1985.

5.9 Oliver, D.W; Dekker, T.G.; Venter, D.P. and Van der Schyf, C.J. (D3 )- Trishomocubane stereoisomerism. Proceedings: 10th South Africa/Israel Binational Symposium on Stereochemistry, Pretoria, South Africa, 1985. Abstract No. P11. 5.10 Squier, G.J.; Van der Schyf, C.J.; Venter, D.P.; Oliver, D. W; Van Rooyen, P.H. and Dillen, J.L.M. Conformational aspects of ring-chlorinated noradrenalines. Proceedings: 10th South Africa/Israel Binational Symposium on Stereochemistry, Pretoria, South Africa, 1985. Abstract No. P15. 5.11 Van der Schyf,. C.J.* The importance of lead generation in drug research. Proceedings: 6th Congress of the Academy of Pharmaceutical Sciences of South Africa, Pretoria, South Africa, 1985. Abstract - S. Afr. Pharm. J., 1985, 52:120. 5.12 Squier, G.J.; Van der Schyf, C.J.; Venter, D.P.; Oliver, D. W; Van Rooyen, P.H. and Dillen, J.L.M. The preferred conformation of ring-chlorinated catecholamines for drug-receptor interactions as calculated with molecular mechanics. Proceedings: 2nd Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus, 1985, Abstract No. 34: p. 33. 5.13 Oliver, D. W; Venter, D.P.; Squier, G.J.; Van der Schyf, C.J.; Van Rooyen, P.H. and Dillen, J.L.M. Ring-chlorinated P3-phenylethylamines. Proceedings: 2nd Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus, 1985, Abstract No. 56: p. 45. 5.14 Van der Schyf, C.J.*; Squier, G.J. and Coetzee, WA. NGP-1-01: Electrophysiological studies on a novel calcium antagonist. Proceedings: Symposium on: Development of Drugs and Modern Medicines, Chelsea, London, U.K., September 1985. Abstract No. 16. 5.15 Squier, G.J.; Van der Schyf, C.J.; Venter, D.P.; Oliver, D. W; Van Rooyen, P.H.. and Dillen, J.L.M. Application of molecular mechanics to catecholamine design. Proceedings: Annual Congress of the

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Pharmacological and Physiological Societies of Southern Africa, Pretoria, South Africa, 1985. Abstract: S. Afr. J. Sci., 82, 442, 1986. 5.16 Liebenberg, W; Van der Schyf, C.J. and Van der Walt, J.J. Amine derivates of pentacyclo undecane - a new series of calcium channel blockers. Proceedings: 7th Congress of the Academy of Pharmaceutical Sciences of South Africa, Cape Town, South Africa, 1986. Abstract- S. Afr. Pharm. J., 1986, 53: 70. 5.17 Van der Schyf, C.J.*; Liebenberg, W and Squier, G.J. Conformational requirements of compounds with calcium antagonistic activity. Proceedings: 7th Congress of the Academy of Pharmaceutical Sciences of South Africa, Cape Town, South Africa, 1986.; Abstract- S. Afr. Pharm. J., 1986, 53: 78. 5.18 Van der Schyf, C.J.*, Liebenberg, W. and Van der Walt, J.J. New calcium antagonists with polycyclic structures - an electrophysiological evaluation. Proceedings: IX International Symposium on Medicinal Chemistry, Berlin (West), Federal Republic of Germany, 1986. Abstract No. 2.5.19, p. 327. 5.19 Liebenberg, W.; Van der Schyf, C.J.; and Van der Walt, J.J. Extended study on the electrophysiological and physicochemical properties of cage- type calcium channel blockers. Proceedings: Annual Congress of the Pharmacological and Physiological Societies of Southern Africa, Bloemfontein, South Africa, 1986. Abstract No. FP 44. 5.20 Van der Schyf, C.J.*" Banijamali, A.R.; Mavromoustakos, T. and Makriyannis, A. The geometric features of tetrahydrocannabinol interactions with membranes as studied by 2 H-Solid state NMR and computer graphics. Proceedings: 3rd Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus, 1987. Abstract No. 45, p. 53s. 5.21 Banijamali,A.R.; Van der Schyf, C.J.; Charalambous,A. and Makriyannis, A. Stereochemical requirements for an addition-elimination reaction in the naturally occuring delta-8 and delta-9 tetrahydrocannabinols. Proceedings: 2nd Annual Meeting of the American Association of Pharmaceutical Scientists, Boston, Massachusetts, USA, 1987. 5.22 Fourie, T.G.; Matthee, E.; Snyckers, F.O.; Dekker, T.G. and Van der Schyf, C.J. A labdane diterpene with anti-inflammatory properties from Elytropappus rhinocerotis. Proceedings: Jubilee Convention "Chemistry in South Africa - Yesterday, Today and Tomorrow": South African Chemical Institute, Durban, South Africa, 1987. Abstract No. P119, p. 51 of Proceedings. 5.23 Makriyannis, A.; Banijamali,A.R. and Van der Schyf, C.J. The orientation of tetrahydrocannabinols in phospholipid bilayers as studied by solid state NMR Models for membrane perturbation. Proceedings of the Congress: "Marihuana '87", Melbourne, Australia, 1987. 5.24 Banijamali, A.; Van der Schyf, C.J. and Makriyannis, A. Tetrahydrocannabinol interactions with model membranes. Proceedings: American Pharmaceutical Association Annual Meeting, Wahington, DC, 1987. Abstract published in J. Pharm. Sci., 1987, 76, S153-S153. 5.25 Van der Walt, J.J.; Van der Schyf, C.J.; Van Rooyen, J.M.; De Jager, J. and Van Aarde, M.N. Frequency and voltage dependent blockade of calcium current in cardiac myocytes by aromatic amines. Proceedings:

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Congress of the Physiological Society of South Africa, Cape Town, South Africa, 1988. 5.26 Van der Schyf, C.J.* Computer Assisted Drug Design. Proceedings: 9th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Port Elizabeth, South Africa, 1988. 5.27 Bornman, R.; Van der Schyf, C.J.; Liebenberg, W; Van Rooyen, P.H. and Dillen, J.L.M. Correlation between stereochemistry and calcium channel blocking activity of NGP1-01. Proceedings: 9th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Port Elizabeth, South Africa, 1988. 5.28 Liebenberg, W.; Van der Schyf, C.J.; Van Rooyen, P.H. and Dillen, J.L.M. The pyrolysis products of pentacyclo-undecane compounds. Proceedings: 9th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Port Elizabeth, South Africa, 1988. 5.29 Snyman, P.E.; Van der Schyf, C.J.; Mavromoustakos, T. and Makriyannis, A. The interaction of NGP 1-01, a polycyclic calcium channel blocker, with DPPC model membranes. Proceedings: 9 th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Port Elizabeth, South Africa, 1988. 5.30 Van der Schyf, C.J.*" Prinsloo, D.P.; Van Rooyen, J.M. and Van der Walt, J.J. The effect of NGP1-01 on impulse conduction in the heart. Proceedings: 9th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Port Elizabeth, South Africa, 1988. 5.31 Van der Schyf, C.J.* and Liebenberg, W Triquinane-type calcium channel blockers - a synthetic approach through thermal fragmentation of pentacyclo [5.4.0.02,6.03,10.05,9] undecane-8,11-dione. Proceedings: 2 1st National Medicinal Chemistry Symposium - Medicinal Chemistry Division, American Chemical Society, Minneapolis, Minnesota, USA, 1988. 5.32 Van der Schyf, C.J.; Mavromoustakos, T. and Makriyannis, A. (-)8a- and 8 13-Hydroxy-A 9 tetrahydrocannabinols. Conformations and effects on model membranes. Proceedings: 3rd Annual Meeting of the American Association of Pharmaceutical Scientists, Orlando, Florida, USA, 1988. 5.33 Mavromoustakos, T.; Charalambous, A.; Van der Schyf, C.J. and Makriyannis, A. Interactions of (-)A8 - and (-)-methoxy-A8- tetrahydrocannabinols with membranes. Proceedings: 3rd Annual Meeting of the American Association of Pharmaceutical Scientists, Orlando, Florida, USA, 1988. 5.34 Marshall, P.R.; Prinsloo, D.P. and Van der Schyf, C.J. Comparison of the vascular actions of a novel calcium channel antagonist, NGP 1-10, with those of nifedipine. Proceedings: 23rd Annual Congress of the South African Pharmacological Society, Port Elizabeth, South Africa, 1988. Abstract No. P23. 5.35 Liebenberg, W. and Van der Schyf, C.J. Structural manipulation of Cookson's well known bird-cage compound. Proceedings: The South African Chemical Institute 30tR Convention: "Chemistry for Southern Africa", Johannesburg, South Africa, 1989. 5.36 Kotz6, P.E.; Mavromoustakos, T.; Makriyannis, A. and Van der Schyf, C.J. X-Ray powder diffraction studies of NGP 1-10 (racemate) and its two

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enantiomers in DOPC- and DMPC-model membranes. Proceedings: 10th Anniversary Conference of The Academy of Pharmaceutical Sciences of Southern Africa: "A Commitment to Health", Sun City, Bophuthatswana, March 13-15, 1989. Served on the Organizing Committee. 5.37 Liebenberg, W.; Van der Schyf, C.J. and Botha, S. Antimicrobial and pharmacological activity of bird-cage compounds and triquinanes. Proceedings: 10th Anniversary Conference of The Academy of Pharmaceutical Sciences of Southern Africa: "A Commitment to Health", Sun City, Bophuthatswana, March 13-15, 1989. Served on the Organizing Committee. 5.38 Van der Schyf, C.J. and Liebenberg, W Triquinane polycyclics as novel drug templates. Proceedings: 4th Cyprus Conference on New Methods in Drug Research, Paphos, Cyprus, 1989. 5.39 Erasmus, E., Mienie, L.J., Van der Schyf, C.J. and Reinecke, C.J. MS and NMR in the detection of organic acidureas. Proceedings: Colloquium on Inborn Errors of Metabolism, Syringa Conference, Mabula Lodge, Warmbaths, South Africa, 18-20 October 1989. 5.40 Swanepoel, K. and Van der Schyf, C.J. Antimicrobial activity of triquinane compounds. Proceedings: 11th Annual Congress of the Academy of Pharmaceutical Sciences, Johannesburg, South Africa, 1990. Served on the Organizing Committee. 5.41 Erasmus, E., Mienie, L.J., Van der Schyf, C.J. and Reinecke, C.J. The use 15 of d3-propionic acid and N-alanine in investigating the formation pathway of a newly detected metabolite, propionylalanine in propionic acidemia. Proceedings: 5 th International Congress on Inborn Errors of Metabolism, Asilomar Conference Center, Pacific Grove, California, 1-5 June 1990. 5.42 Van der Schyf, C.J. and Swanepoel, K. Natural Products as Drug Templates: Coriolin-Like Antimicrobial Triquinane Amines. Proceedings: Bonn-Bacans: Biology and Chemistry of Active Natural Substances, Bonn, Federal Republic of Germany, 1990. Abstract P 31 0, p. 161. 5.43 Van der Walt, J.J., Van der Schyf, C.J., Van Aarde, M.N. and Van Rooyen, J.M. Calcium and potassium channel blockade by polycyclic amines. Proceedings: International Symposium on Ionic Currents and Ischemia, Corsendonck, Belgium, September, 1990. Abstract: "Ionic Currents and Ischemia" Leuven University Press, pp. 332. 5.44 Erasmus, E., Mienie, L.J., Van der Schyf, C.J., Knoll, D.P., Willemse, R. and De Wet, W.J. A new generation of low-concentration conjugates in propionic acidemia. Proceedings: 10th Congress of the South African Biochemical Society, University of Natal, Pietermarizburg, South Africa, January 27-30, 1991. 5.45 Malan, S.F.; Van der Schyf, C.J. and Van der Walt, J.J. The synthesis of polycyclic amine derivatives: New possibilities for calcium channel activity. Proceedings: 12th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Potchefstroom, South Africa, April 18-20, 1991, Abstract No C8, p. 74. Served as Congress Convenor. 5.46 Dockendolf, G. and Van der Schyf, C.J. Computer-aided synthesis of new calcium channel antagonists. Proceedings: 12th Annual Congress of the

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Academy of Pharmaceutical Sciences of South Africa, Potchefstroom, April 18-20, 1991, Abstract No C3, p. 69. Served as Congress Convenor. 5.47 Erasmus, E., Mienie, L.J., Van der Schyf, C.J., Knoll, D.P., Willemse, R. and De Wet, WJ. A new generation of low-concentration conjugates in propionic acidemia. Proceedings: 2nd International Congress on Amino Acids and Analogs, Vienna, Austria, August 5-9, 1991. 5.48 Erasmus, E., Mienie, L.J., Van der Schyf, C.J., Knoll, D.P., Willemse, R. and De Wet, WJ. A new generation of low-concentration conjugates in propionic acidemia. Proceedings: 15th International Congress of Biochemistry, Jerusalem, Israel, August, 1991. 5.49 Dockendolf, G; Van der Schyf, C.J. and Van Rooyen P.H. The X-ray crystal structure and NMR study of 3-benzylamino-3-cyano-7,10- dioxaspiro[4.5]decane. Proceedings: 13th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Somerset West, South Africa, 1992, p. 76. 5.50 Malan, S.F.; Van der Schyf, C.J.; Van der Walt, J.J. and Van Aarde, M.N. The synthesis, structure and calcium channel activity of 6-benzylamino-3- 3 hydroxyhexacyclo[6.5.0.03,7.05,10.09,1 ]-tridecane. Proceedings: 13 th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Somerset West, South Africa, 1992. p. 816. 5.51 Van der Schyf, C.J.; Van der Walt, J.J.; Liebenberg, W and Van Aarde, M.N. The influence of minor structural changes on some electrophysiological effects of two polycyclic amines. Proceedings: 5 th Cyprus Conference on New Methods in Drug Research, Larnaca, Cyprus, 1992, Abstract No. 29, p. 44. 5.52 Fourie, T.G.; Snyckers, F.O.; Swart, I. and Van der Schyf, C.J. Calcium antagonistic activity of a range of polycyclic amines. Proceedings: 14th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, 1993, Abstract No. C3, Page 32. 5.53 Dockendolf, G. and Van der Schyf, C.J. Molecular geometry fits as a predictor mechanism for the synthesis of novel compounds with ion channel activity. Proceedings: 14th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, 1993, Abstract No. C2, Page 31. 5.54 Malan, S.F.; Van den Heever, I.; Van der Schyf, C.J.; and Van der Walt, J.J. Evaluation of screening tests for calcium channel activity. Proceedings: 14th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, 1993, Abstract No. C4, Page 33. 5.55 Malan, S.F.; Van der Schyf, C.J.; Van der Walt, J.J.; Van Rooyen, J.M. and Van Aarde, M.N. Electrophysiological characterization of the calcium channel activity of some novel polycyclic amines. Proceedings: 6th Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus, 1994. 5.56 Dockendolf, G. and Van der Schyf, C.J. Synthesis and structural investigation of the cyclopentadiene/2-chloro-p-benzoquinone adduct. Proceedings: 6th Cyprus Conference on New Methods in Drug Research, Limassol, Cyprus, 1994.

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5.57 Malan, S.F.; Van der Schyf, C.J.; Van der Walt, J.J.; Van Rooyen, J.M. and Van Aarde, M.N. Electrophysiology and ion channel activity of some diverse polycyclic amines. Proceedings: 15th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Grahamstown, South Africa, 1994. Abstract No. B2, J. Modern Pharm., 1(6), S3. 5.58 Van der Schyf, C.J. Chiral polycyclic diketone templates for CIS-SYN-CIS triquinane drug precursors. Proceedings: 5th International Symposium on Chiral Discrimination, Stockholm, Sweden, 1994. Abstract No. OC:74 5.59 Malan, S.F., Van der Walt, J.J., Van Rooyen, J.M., Van Aarde, M.N. and Van der Schyf, C.J. Polycyclic amines - calcium channel activity and QSAR. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. P5, Page 37. 5.60 Keeve, R., Mienie, L.J. and Van der Schyf, C.J. Identification of metabolites of haloperidol in the urine of baboons by TLC and GC-MS. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. P3, p35. 5.61 Keeve, R.,Van der Schyf, C.J., Dormehl, I.C., Oliver, D.W., Hugo, N., Muller-Gartner, H.-W., Pond, S.M. and Castagnoli, N., Jr. Dopamine receptor imaging with SPECT in subhuman primates after treatment with HPTP, the tetrahydropyridine analog of haloperidol. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. P6, p38. 5.62 Van Staden, E., Mienie, L.J., Bergh, J.J. and Van der Schyf, C.J. The urinary organic acid profiles of baboons and humans: a study in interprimate variation. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. P7, p39. 5.63 Dockendolf, G., Van der Schyf, C.J., Van't Land, C. and Castagnoli,N., Jr. Conformational studies of the pyridinium and reduced metabolites of haloperidol. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. P8, p40. 5.64 Mattheus, A., Van der Schyf, C.J., Van der Watt, J.G. and Marais, A.F. The water solubility and molecular association of furosemide. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. P24, p56. 5.65 Steyn, S.J., Mienie, L.J. and Van der Schyf, C.J. Haloperidol-induced neurotoxicity: Inhibition of Complex I of the electron transport chain may not be the only explanation. Proceedings: 16th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Bloemfontein, South Africa, 1995. Abstract No. LI, p18. 5.66 Malan, S.F., Van der Walt, J.J., Van Rooyen, J.M., Van Aarde, M.N. and Van der Schyf, C.J. Structure-activity relationships of polycyclic aromatic amines with calcium channel activity. Proceedings: 1 0 th Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, Miami Beach FL, USA, November 5-9, 1995. Abstract: Pharmaceutical Research (New York), 1995, 12 (9-S), S124.

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5.67 Bergh, J.J. and Van der Schyf, C.J. Structure-activity relationship of a series of phlorophenone derivatives with antimicrobial activity. Proceedings: 10 th Annual Meeting of the American Association of Pharmaceutical Scientists, Miami Beach FL, USA, November 5-9, 1995. Abstract: PharmaceuticalResearch (New York), 1995, 12 (9-S), S125. 5.68 A vent, K., Van der Schyf, C.J., Eyles, D., Castagnoli,N, Jr.and Pond, S.M. The quantitative analysis of a haloperidol derivative and its neurotoxic metabolites in baboons. Proceedings: 2 0 th Collegium Internationale Neuro-Psychopharmacologicum, Melbourne, Australia, June 23-27, 1996. Abstract: Eur. NeuropsychopharmacoL, 1996, 6, Suppl. 3, 37. 5.69 Dockendolf, G., Van't Land, C. W, Glass, T.E., Castagnoli, N., Jr and Van der Schyf, C.J. NMR and semi-empirical molecular modeling studies of the tetrahydropyridine and reduced metabolites of haloperidol. Proceedings of The First International Conference on Pharmaceutical and Pharmacological Sciences, Midrand, South Africa, September 1996. 5.70 Bergh, J.J., Van Staden, E., Mienie, L.J., Castagnoli, N., Jr. and Van der Schyf, C.J. Metabolic defects caused by HPTP, the tetrahydropyridine analog of haloperidol, in baboons. Proceedings of The First International Conference on Pharmaceutical and Pharmacological Sciences, Midrand, South Africa, September 1996. 5.71 Steyn, S.J., Mienie, L.J., Castagnoli,N., Jr. and Van der Schyf, C.J. The in situ mitochondrial toxicities of haloperidol, MPTP and some of their major metabolites in human leukocytes. Proceedings of The First International Conference on Pharmaceutical and Pharmacological Sciences, Midrand, South Africa, September 1996. 5.72 Malan, S.F., Van der Walt, J.J., Wagenaar, B. and Van der Schyf, C.J. The structure and ion channel activity of 6-benzylamino-3-hydroxy hexacyclo[6.5.0.0 '37 .04' 12.0 5'10 .09'13]tridecane. Proceedings: 11th Annual Meeting of the American Association of Pharmaceutical Scientists (AAPS), Seattle, WA, USA, October 27-31, 1996. Abstract: PharmaceuticalResearch (New York), 1996, 13 (9-S), S143. 5.73 Steyn, S.J., Mienie, L.J., Castagnoli, N., Jr., Riker, R.R. and Van der Schyf, C.J. A biochemical profile indicative of severe mitochondrial toxicity in patients treated with high doses of haloperidol. Proceedings: 14tn Conference of the South African Society of Biochemistry and Molecular Biology. Grahamstown, January, 1997. Abstract No. 5.74 Dheyongera, J.P., Van der Schyf, C.J., Dekker, T.G. and Wachira, J.M. Synthesis and in vitro cytotoxicity of novel DNA intercalating thioacridones. Proceedings: F.L. Warren Conference on Chemistry, Durban, Natal, South Africa, June 29 - July 3, 1997. Abstract No. 5.75 Steyn, S.J., Mienie, L.J., Castagnoli, N., Jr., Riker, R.R. and Van der Schyf, C.J. High-dose haloperidol treatment causes a biochemical profile indicative of severe mitochondrial toxicity in patients. Proceedings: 3rd SONA International Neuroscience Conference and 2nd IBRO Regional Congress, Cape Town, South Africa, April 21-25, 1997. Abstract No. 5.76 Dockendolf, G. and Van der Schyf, C.J. Dopamine D2-receptor modeling using haloperidol conformation in solution. Proceedings: 12th Annual Meeting of the American Association of Pharmaceutical Scientists

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(AAPS), Boston, MA, USA, November 2-6, 1997. Pharmaceutical Research (New York), 14, S390-S391. 5.77 Mahapatra, V., Van der Schyf, C.J. and Misra, H. Haloperidol-induced tardive dyskinesia: are reactive oxygen species involved? Proceedings: 1998 Society of Toxicology (SOT) Annual Meeting, Seattle, WA, March 1- 5, 1998. Abstract No. 752. The Toxicologist, 1998, 42 (1-S), 152-153. 5.78 Van der Schyf, C.J., Castagnoli, K., Palmer, S. and Castagnoli, N., Jr. Melatonin fails to protect against MPTP-induced dopamine depletion in mouse striatum. Proceedings: 1998 Society of Toxicology (SOT) Annual Meeting, Seattle, WA, March 1-5, 1998. Abstract No. 1616. The Toxicologist, 1998, 42 (1-S), 328. 5.79 Malan, S.F., Dockendolf, G., and Van der Schyf, C.J. Enantiomeric resolution and calcium channel activity of 8-benzylamino-8,11- oxapentacyclo[5.4.0.0 2' 6.03'1°.0 5'9]undecane. Proceedings: The 17th Pharmaceutical Technology Congress and Exhibition, Dublin, Ireland, March, 1998. Conference proceedings vol. 3. 5.80 Bergh, J.J., Van Staden, E., Mienie, L.J., Pond, S.M., Bloomquist, J.R., Freeborn, E., Castagnoli, N., Jr., and Van der Schyf, C.J. p- Fluorophenylglycine in the urine of baboons treated with HPTP, the tetrahydropyridine analog of haloperidol. Proceedings: 19th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, June 28 - July 1, 1998. Abstract No. 5.81 Petzer, J.P., Bergh, J.J., Mienie, L.J., and Van der Schyf, C.J. Mitochondrial injury caused by selected tertiary amines. Proceedings: 19tn Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, June 28 - July 1, 1998. Abstract No. 5.82 Dockendolf G., and Van der Schyf, C.J. Comparison of Log P values for haloperidol metabolites and analogs calculated by several methods. Proceedings: 1 9 th Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, June 28 - July 1, 1998. Abstract No. 5.83 Dheyongera, J.P., Van der Schyf, C.J., Dekker, T.G., Wachira, J.M. and Matsabisa, M.G. Synthesis and antimalarial evaluation of some thiocridone derivatives. Abstracts of Papers of the 7th International Chemistry Conference in Africa and 34th Convention of the South African Chemical Institute University of Natal, Durban, South Africa, July 6-10, 1998. 5.84 Castagnoli,K., Van der Schyf, C.J. and Castagnoli, N., Jr. Studies on the neuroprotective properties of MAO-B inhibitors. Abstracts of Papers of the American Chemical Society, 216: U576-U576 107-TOXI , Part 1 Aug. 23, 1998. 5.85 Castagnoli, N., Jr., Castagnoli, K., and Van der Schyf, C.J. Enzyme catalyzed bioactivation of cyclic tertiary amines to neurotoxins. Proceedings: Xlllth Congress of the Polish Pharmacological Society, Katowice, Poland, September 13-16, 1998. Abstract No. 5.86 Castagnoli, K., Van der Schyf, C.J. and Castagnoli, N., Jr. Monoamine oxidase B inhibition and neuroprotection. Proceedings: Xlllth Congress of the Polish Pharmacological Society, Katowice, Poland, September 13-16, 1998. Abstract No.

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5.87 Dheyongera, J.P., Van der Schyf, C.J., Dekker, T.G., Wachira, J.M. and Matsabisa, M.G. Synthesis and antimalarial evaluation of some thiocridone derivatives. Abstracts of Papers of the Multilateral Initiative on Malaria. African Malaria Conference, Durban, South Africa, March 14-19, 1999. 5.88 Bergh, J.J., Loots, DuT., Mienie, L.J. and Van der Schyf, C.J. Acetyl-L- carnitine prevents hydroxyl free radical production induced by 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP). Abstracts of Papers of the American Association of Pharmaceutical Scientists (AAPS), New Orleans, LA, November 14-18, AAPS PharmSci 1999 AAPS Annual Meeting Supplement 1999; 1 (4); Available from: http://www.aapspharmaceutica. com/scientificjournals/pharmsci/amabstracts/1 999/1567. htm 5.89 Bergh, J.J., Petzer, J.P., Mienie, L.J., Castagnoli, N., Jr and Van der Schyf, C.J. In vivo effect of deprenyl and ketokonazole on the metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and HPTP (the tetrahydropyridinyl analog of haloperidol), in the rat. Abstracts of Papers of the American Association of Pharmaceutical Scientists (AAPS), New Orleans, LA, November 14-18, AAPS PharmSci 1999 AAPS Annual Meeting Supplement 1999; 1 (4); Available from: http://www. aapspharmaceutica.com/scientificjournals/pharmsci/amabstracts/1 999/2 515.htm 5.90 Wouters, J., Ooms, F., Durant, F., Khalil, A.A., Steyn, S., Castagnoli,N. Jr and Van der Schyf, C.J. Interaction of a tobacco component, 2,3,6- trimethyl-l1,4-naphthoquinone, with the catalytic site of MAO-A and -B: A molecular modeling study. Abstracts of Papers of the 9th International Amine Oxidases Workshop Barcelona, Spain, July 9-12, 2000. 5.91 Dockendolf, G., Van der Schyf, C.J., Mienie, L.J., Van den Heever, I., and Bergh, J.J. a-Phenylglycine in the urine of rats treated with styrene: the presence of phenylglycine aminotransferases in the rat. Proceedings: 21st Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Grahamstown, South Africa, September 10-13, 2000. Abstract No. 5.92 Castagnoli, K., Steyn, S.J., Magnin, G., Van der Schyf, C.J., Fourie, I., Khalil A., and Castagnoli, N., Jr. Interactions of tobacco leaf and tobacco smoke constituents with monoamine oxidase. Proceedings: Neurotoxicity Meeting, Pucon, Chile, March 15-17, 2001. Abstract No. 5.93 Terre'Blanche, G., Heyer, N., Bergh, J.J., Mienie, L.J. and Van der Schyf, C.J. The presence of a glutatic aciduria type II profile in the urine of rats treated with phenylglyoxylic acid. Abstracts of Papers of the American Association of Pharmaceutical Scientists (AAPS), Annual Meeting, AAPS 2001 Annual Meeting and Exposition, Denver, CO, October 21-25, 2001. AAPS PharmSci 2001 AAPS Annual Meeting Supplement 2001; 3 (3); Available from: http://www.aapspharmaceutica.org/search/view.asp? id=2016 5.94 Massicotte, C., Van der Schyf, C.J., Jortner,B.S. and Ehrich, M. Effects of neuropathy-inducing organophosphorus (OP) compounds on mitochondrial ATP production in primary dorsal root ganglia cell cultures.

Proceedings: 4 0 th Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. Abstract No.

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5.95 Van der Schyf, C.J. The Tobacco Smoke Pharmacopeia. Invited seminar: Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, Oxford, MS, April 9, 2002. 5.96 Van der Schyf, C.J. Caging Alzheimer's Disease: polycyclic compounds that combat neurodegeneration and aging. Invited seminar: Department of Chemistry, College of Arts and Sciences, University of North Texas, Denton, TX, September 13, 2002. 5.97 Castagnoli, K., Fourie, I., Van der Schyf, C.J., Murugesan, T. and Castagnoli, N., Jr. On the inhibition of monoamine oxidase by tobacco smoke. Abstracts of Papers of the American Chemical Society, 224: U370-U370 053-TOXI Part 1 Aug, 18, 2002. ACS Boston National Meeting, August 18-22, 2002. 5.98 Castagnoli, N., Jr., Petzer, J.P., Steyn, S., Castagnoli, K.P., Chen, J.-F., Schwarzschild, M.A., and Van der Schyf, C.J. Inhibition of Monoamine Oxidase B by Selective Adenosine A2A Receptor Antagonists. Translating Adenosine A2A Receptor Biology into Novel Therapies for Parkinson's Disease: An International Research Conference, Conference Proceedings, p. 20, Boston, Massachusetts, September 25-27, 2002. 5.99 Van der Schyf, C.J., Petzer, J.P. and Castagnoli,N., Jr. The synthesis and evaluation of caffeine analogs as dual adenosine A2a receptor antagonists and inhibitors of monoamine oxidase B. Invited seminar: Annual Faculty Research Meeting, College of Health Sciences, Potchefstroom, South Africa, October 10-11, 2002. 5.100 Van der Schyf, C.J. Dual blockers of L-type calcium channels and NMDA receptors: new strategies in the treatment of Alzheimer's Disease. Invited seminar: Department of Pharmaceutical Chemistry, College of Health Sciences, Potchefstroom University, Potchefstroom, South Africa, October 17, 2002. 5.101 Van der Schyf, C.J. Perspectives on the attenuation of Parkinson's Disease in tobacco smokers. Invited seminar: Department of Pharmaceutical Chemistry, College of Health Sciences, Potchefstroom University, Potchefstroom, South Africa, October 24, 2002. 5.102 Geldenhuys, WJ., Malan, S.F., Van der Schyf, C.J. and Bloomquist J.R. Interaction of trishomocubane analogs of amantadine with the dopamine transporter. Proceedings: Society for Neuroscience 3 2 nd Annual Meeting, Orlando, FL, November 2-7, 2002. Abstract No. 787.13 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online. 5.103 Van der Schyf, C.J. Caging Calcium: Strategies for Neuronal Loss Prevention in Ischemia and Neurodegenerative Disorders. Seminar Speaker: Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, December 13, 2002. 5.104 Geldenhuys, W.J., Malan, S.F., Van der Schyf, C.J. and Bloomquist J.R. Interaction of trishomocubane analogs of amantadine with the dopamine transporter. Proceedings: First Regional "Brain Walk of Fame" Poster Gallery of the West Texas Chapter of the Society for Neuroscience, Lubbock, Texas, November 25 - December 6, 2002. Abstract No. 33.

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5.105 Correll, L., Massicotte, C., Van der Schyf, C.J. and Ehrich, M. In Situ Effects of Organophosphate (OP) Compound Exposure on ATP Production in Human Neuroblastoma Cells. Proceedings: 4 2 nd Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2003. Referenced in: Toxicol. Sci. Suppl: The Toxicologist, 2003, 72(1): 267-267 1299 Suppl. S. 5.106 Geldenhuys, W.J., Steelman, K., Bloomquist, J.R., Van der Schyf, C.J., and Malan, S.F. Pentacycloundecylamjnes as novel N-methyl-D-aspartate receptor antagonists. Proceedings: 24tn Annual Congress of the Academy of Pharmaceutical Sciences of South Africa, Durban, South Africa, September 7-19, 2003. Abstract No. 5.107 Geldenhuys, WJ., Steelman, K., Malan, S.F., Bloomquist J.R. and Van der Schyf, C.J. Pharmacological Evaluation of Pentacyclo-undecylamine Derivatives as Novel Uncompetitive N-methyl-D-aspartate (NMDA) Receptor Antagonists. Proceedings: Second Annual Research Days Event, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas, June 2-3, 2003. Abstract No. 23.

5.108 Ooms, F., Fr6d6rick, R., Durant, F., Petzer, J.P., Castagnoli,N., Jr., Van der Schyf, C.J., and Wouters, J. (2003) Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-indeno[1,2-c]pyridazin-5-one derivative. Chemlnform, 34, pp. DOI: 10.1002/chin.200323137. 5.109 Robbertse, G., Bergh, J.J., Mienie, L.J., and Van der Schyf, C.J. The haloperidol metabolite, p-chlorobenzoic acid, reduces ubiquinone-10 concentrations and affects the urinary organic acid profile in baboon. Proceedings: Second Annual Research Days Event, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas, June 2-3, 2003. Abstract No. 33. 5.110 Malan, S.F., Dyason, K., Wagenaar, B., Van der Walt, J.J., and Van der Schyf, C.J. (2003) The structure and ion channel activity of 6- 3 7 4 13 benzylamino-3-hydroxyhexacyclo[6.5.0.0 ' .0 ' 12.05 ,0.0 ]tridecane. Chemlnform, 34, pp. DOI: 10.1002/chin.200330098. 5.111 Geldenhuys, WJ., Steelman, K., Malan, S.F., Bloomquist, J.R., Van der Schyf, C.J. Pharmacological evaluation of pentacycloundecane derivatives as novel noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Interaction of trishomocubane analogs of amantadine with the dopamine transporter. Proceedings: Society for Neuroscience, 3 3 rd rd Annual Meeting, New Orleans, LA, November 8-12, 2003. Abstract No. 892.15 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. Online. 5.112 Van der Schyf, C.J. Polycyclic Cage Amines in Neurodegenerative Disorders. Invited Seminar Speaker: Chemistry and Biochemistry Departmental Seminar Series, Texas Tech University, Lubbock, TX, December 9, 2003. 5.113 Van der Schyf, C.J. Divalent Cation Flux as a Drug Target in Neurodegeneration. Invited Seminar Speaker: School-wide Seminar Series, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Dallas, Lubbock TX, February 23, 2004.

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5.114 Kiewert, C., Van der Schyf, C.J., Hartmann, J., Stoll, J., Thekkumkara, T., Klein, J. Neuroprotective effects of NGP1-01, a Polycyclic Amine. Proceedings: 1 6 t Annual Student Research Week, March 29 - April 2, 2004. Texas Tech University Health Sciences Center, Lubbock TX, Poster # GF6. 5.115 Abbruscato, TJ., Bickel, U., Klein, J., Van der Schyf, C.J. Research Center: Pathophysiology and Treatment of Stroke - PATOS. Lighting the Path to Preeminence Symposium, April 17, 2004. Texas Tech University Health Sciences Center, Lubbock, TX. 5.116 Geldenhuys, WJ., Klein, J., Malan, S.F., Bloomquist, J.R., Murugesan, T., Van der Schyf, C.J. Inhibition of Monoamine Oxidase B by derivatives of pentacyclo[5.4.0.0 2' 6.03'10.05'9]undecane. Proceedings: Microsomes and Drug Oxidations 2004: Chemical Biology in the Postgenomic Era - New Approaches and Applications. Mainz, Germany, July 4- 9, 2004. 5.117 McHazlett, P., Geldenhuys, W, Kiewert, C., Klein, J., Van der Schyf, C.J. Investigation of novel drug targets in Alzheimer's disease. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 12, p. 16. 5.118 Mdzinarishvili, A., Geldenhuys, W, Bickel, U., Klein, J., Abbruscato, T., Van der Schyf, C.J. Neuroprotection by NGPl-01 in the MCAO murine stroke model. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 13, p. 17. 5.119 Favila, H., Geldenhuys, W.J., Kiewert, C., Pope, K., Klein, J., Van der Schyf, C.J. Effects of putative neuroprotective agents in rat hippocampal slices subjected to oxygen-glucose deprivation. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 28, p. 38. 5.120 Geldenhuys, WJ., Murugesan, T., Bloomquist, J., Malan, S.F., Van der Schyf, C.J. Binding site computer modeling of the inhibition of monoamine oxdase B by pentacycloundecane amines. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 30, p. 40. 5.121 Geldenhuys, WJ., Lockman, P.R., McAfee, J.H., Fitzpatrick,K.T., Van der Schyf, C.J., Allen, D.D. CoMFA and CoMSIA 3D-QSAR studies on the active binding site of the blood-brain barrier choline transporter. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. I, p. 41. 5.122 Terre'Blanche, G., Geldenhuys, WJ., Van der Schyf, C.J. Computer model for binding of haloperidol and its tetrahydropyridine analog HPTP to the dopamine D2 receptor. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. J, p. 42. 5.123 Kiewert, C., Van der Schyf, C.J., Hartmann, J., Stoll, J., Thekkumkara, T., Klein, J. Neuroprotective effects of NGP1-01, a polycyclic amine. Proceedings: Texas Tech University Health Sciences University School of

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Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 32, p. 44. 5.124 Lockman, P.R., Van der Schyf, C.J., Paulson, J.R., Abbruscato, T.J., Allen, D.D. Chronic nicotine exposure diminishes brain uptake of methyllycaconitine. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 33, p. 45. 5.125 Paulson, J., Mdzinarishvili, A., Roder, K., Thomas, J., Lopez, S., Robbertse, G., Van der Schyf, C.J., Abbruscato, T. Nicotine effects on potassium transport of the blood brain barrier during stroke. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 41, p. 53. 5.126 Robbertse, G., Nguyen, T., Lockman, P.R., Allen, D.D., Bergh, J.J, Van der Schyf, C.J. Effect of nicotine and cigarette smoke extracts on the in vivo regulation of striatal tyrosine hydroxylase. Proceedings: Texas Tech University Health Sciences University School of Pharmacy, 3 rd Annual Research Days, Amarillo, TX, July 29-30, 2004. Abstract No. 43, p. 55. 5.127 Robbertse, G., Nguyen, T., Lockman, P.R., Allen, D.D., Van der Schyf, C.J. Effect of nicotine and cigarette smoke extracts on the in vivo regulation of striatal tyrosine hydroxylase and dopamine transporter. Proceedings: Society for Neuroscience, 3 4 th Annual Meeting, San Diego, CA, October 23-27, 2004. Abstract No. 678.21 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online. 5.128 Paulson J., Mdzinarishvilli, A., Roder, K., Thomas, J., Robbertse, G., Van der Schyf, C.J., Abbruscato, T. Nicotine exposure alters blood-brain barrier potassium transport and stroke outcome in a murine MCAO stroke model. Proceedings: Society for Neuroscience, 3 4 th Annual Meeting, San Diego, CA, October 23-27, 2004. Abstract No. 430.15 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online. 5.129 Mdzinarishvilli, A., Geldenhuys, W., Bickel, U., Klein. J., Abbruscato, T., Van der Schyf, C.J. Neuroprotection by NGP1-01 in the MCAO murine stroke model. Proceedings: Society for Neuroscience, 3 4 th Annual Meeting, San Diego, CA, October 23-27, 2004. Abstract No.103.6 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online. 5.130 Lockman, P.R., Koziara, J.M., Van der Schyf, C.J., Abbruscato, TJ., Paulson, J.R., Robbertse, G., Nguyen, T., Vemula, S., Roder, K.E., Allen, D.D. In-situ evidence for downregulation of the blood-brain barrier endothelial nicotinic acetylcholine a7 receptor. Proceedings: Society for Neuroscience, 3 4 th Annual Meeting, San Diego, CA, October 23-27, 2004. Abstract No. 198.9 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004. Online. 5.131 Geldenhuys, W.J., Murugesan, T., Malan, S.F., Bloomquist, J.R., Van der Schyf, C.J. Molecular modeling studies on the inhibition of monoamine oxidase B by pentacycloundecylamines. Proceedings: Society for Neuroscience, 34t. Annual Meeting, San Diego, CA, October 23-27, 2004.

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Abstract No. 496.10 2004 Abstract Viewer/Itinerary Planner.Washington, DC: Society for Neuroscience, 2004. Online. 5.132 Lockman, P.R., Koziara, J.M., Abbruscato, T.J., Paulson, J.R., Vemula, S., Roder, K.E., Van der Schyf, C.J., Allen, D.D. Nicotine alters brain microvascular endothelial nicotinic acetylcholine a7 receptor expression. Proceedings: American Association of Pharmaceutical Scientists (AAPS) 2004 AAPS Annual Meeting and Exposition, Baltimore, MD, November 7- 11, 2004. Published in The AAPS Journal,6(4), Abstract W4127 (2004). 5.133 Pal, A., Lockman, P.R., Roder, K.E., Abbruscato, T.J., Van der Schyf, C.J., Allen, D.D. Nicotine Induced Alterations in Brain Uptake of D- Glucose. Abstracts: The 2 nd Biennial West Texas Regional Neuroscience Poster Gallery November 2 2 nd - December 3 rd 2004, TTUHSC, Lubbock, TX. Abstract No. 18. 5.134 Lockman, P.R., Van der Schyf, C.J., Paulson, J.R., Abbruscato, T.J., Allen, D.D. Chronic Nicotine Exposure Diminishes Brain Uptake Of Methyllycaconitine. Abstracts: The 2 nd Biennial West Texas Regional Neuroscience Poster Gallery November 2 2 nd - December 3 rd, 2004, TTUHSC, Lubbock, TX. Abstract No. 19. 5.135 Geldenhuys, W.J., Murugesan, T., Malan, S.F., Bloomquist, J.R., Van der Schyf, C.J. Molecular modeling studies on the inhibition of monoamine oxidase by pentacycloundecylamines. Abstracts: The 2 nd Biennial West Texas Regional Neuroscience Poster Gallery November 2 2 nd - December 3 rd, 2004, TTUHSC, Lubbock, TX. Abstract No. 29. 5.136 Robbertse, G., Nguyen, T., Lockman, P.R., Allen, D.D., Bergh, J.J., Van der Schyf, C.J. Effect of nicotine and cigarette smoke extracts on the in vivo regulation of striatal tyrosine hydroxylase and dopamine transporter. Abstracts: The 2 nd Biennial West Texas Regional Neuroscience Poster Gallery November 2 2 nd - December 3 rd, 2004, TTUHSC, Lubbock, TX. Abstract No. 30. 5.137 Sorensen, I.F., Van der Schyf, C.J., Castagnoli, N., Jr. Are pyrolysis products in cigarette smoke neuroprotective? Second Annual Conference, the Global College of Neuroprotection and Neuroregeneration, March 7-9, 2005, Innsbruck, Austria, p 52. 5.138 Geldenhuys, W.J., Malan, S.F., Bloomquist, J.R., Marchand, A.P., and Van der Schyf, C.J. (2005) Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: A focus on pentacycloundecane derivatives. Chemlnform, 36, pp. DOI: 10.1002/chin.200513272. 5.139 Kiewert, C., Van der Schyf, C.J., Hartmann, J., Stoll, J., Thekkumkara, T., Klein, J. Neuroprotective effects of NGP1-01, a polycyclic amine. Abstracts: Proceedings of the 3 5 th Congress of the International Union of Physiological Sciences (IUPS) and the 2005 Experimental Biology Meeting [accessed at http://select.biosis.orq/fasebl. FASEB Journal, 18, Abstract No. 628, and FASEB Journal, 19, Al 081. 5.140 Van der Schyf, C.J. Multi-targeted Approaches in Drug Design for Alzheimer's Disease. Invited seminar for Dean's Annual Grand Rounds 2005: "Untangling Alzheimer's: New Research at Texas Tech". May 5, 2005, Lubbock, Texas.

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5.141 McHazlett, P., Geldenhuys, W.J., Kiewert, C., Klein, J., Van der Schyf, C.J. Investigation of novel drug targets in Alzheimer's disease. The Foundation for Health in Aging Student Research Fund Stipend Recipient Invited Poster presentation, Abstracts: 2005 Annual Scientific Meeting of the American Geriatrics Society (AGS), May 11 - 15, Orlando, Florida. 5.142 Geldenhuys, W.J., Malan, S.F., Klorig, D.C., Bloomquist, J.R., Van der Schyf, C.J. Design of an adamantine amine that binds to the PCP binding site of the NMDA receptor. Abstracts: 4th Annual Research Days TTUHSC School of Pharmacy, July 28-29, 2005, Amarillo, Texas. 5.143 Gaasch, J.A., Geldenhuys, W.J., Van der Schyf, C.J., Allen, D.D, Lockman, P.R., Iron toxicity in neuronal cells via entry through the L-type calcium channel. Abstracts: 4th Annual Research Days TTUHSC School of Pharmacy, July 28-29, 2005, Amarillo, Texas. 5.144 Kiewert, C., Mdzinarishvili, A., Hartmann, J., Kumar, V., Abbruscato, T.J., Bickel, U., Van der Schyf, C.J., Klein, J. An experimental microdialysis- stroke combination model to monitor stroke markers. Abstracts: 4th Annual Research Days TTUHSC School of Pharmacy, July 28-29, 2005, Amarillo, Texas. 5.145 Lockman, P.R., Allen, D.D., Mdzinarishvili, A., Bickel, U., Geldenhuys, W.J., Van der Schyf, C.J., Gaasch, J.A. Vasoconstriction and blood-brain barrier disruption after subarachnoid hemorrhage. Abstracts: 4th Annual Research Days TTUHSC School of Pharmacy, July 28-29, 2005, Amarillo, Texas. 5.146 Paulson, J.R., Roder, K.E., Wilhelm, A., Mdzinarishvili,A., Van der Schyf, C.J., Bickel, U., Klein, J., Abbruscato, T.J. Nicotine exacerbates edema of hippocampal brain slices in an oxygen-glucose deprivation model. Abstracts: 4th Annual Research Days TTUHSC School of Pharmacy, July 28-29, 2005, Amarillo, Texas. 5.147 Thomas, F.C., Geldenhuys, W.J., Lockman, P.R., Van der Schyf, C.J., Crooks, P.A., Dwoskin, L.P., and Allen, D.D. 3D-QSAR studies on the affinity of rigid bis-quaternary nicotinium compounds for the blood-brain barrier choline transporter. Abstracts: 4th Annual Research Days TTUHSC School of Pharmacy, July 28-29, 2005, Amarillo, Texas. 5.148 Thomas, F.C., Geldenhuys, W.J., Lockman, P.R., Nguyen, T.H., Van der Schyf, C.J., Crooks, P.A., Dwoskin, L.P., and Allen, D.D. 3D-QSAR studies on the affinity of rigid bis-quaternary nicotinium compounds for the blood-brain barrier choline transporter. Abstracts: 2005 AAPS Annual Meeting and Exposition, November 6-10, 2005, Nashville, TN. 5.149 Ballman, K., Gaasch, J., Lockman, P.R., Geldenhuys, W.J., Van der Schyf, C.J., Allen D.D. Cellular iron overload in mitochondrial dysfunction and total neuronal cell death resulting from an in vitro model of subarachnoid hemorrhage. Abstracts: 8th Annual Merck Pharmacy Student Research Conference Western Region, June 3-4, 2005, Denver, Colorado. 5.150 Kiewert, C., Mdzinarishvili, A., Hartmann, J., Kumar, V., Abbruscato, T.J., Bickel, U., Van der Schyf, C.J., Klein, J. Monitoring of extracellular metabolites during experimental stroke by microdialysis. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 130.1. 2005 Abstract

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Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.151 Gaasch, J.A., Geldenhuys, W.J., Van der Schyf, C.J., Allen, D.D., Lockman P.R. Iron enters neuronal cells via the L-type calcium channel in an in vitro model of subarachnoid hemorrhage. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 130.13. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.152 Lockman, P.R., Gaasch, J., Geldenhuys, WJ., Abbruscato, T.J., Van der Schyf, C.J., Allen D.D. Blood-brain barrier choline transport is not altered after chronic nicotine exposure. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 190.14. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.153 Paulson, J.R., Roder, K.E., Mdzinarishvili, A., Van der Schyf, C.J., Bickel, U., Klein, J., Abbruscato T.J. Nicotine exacerbates edema associated with focal ischemia and oxygen glucose deprivation in hippocampal brain slices. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 468.7. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.154 Lockman, P.R., Gaasch, J.A., Mdzinarishvili, A., Bickel, U., Geldenhuys, WJ., Van der Schyf, C.J., Allen D.D. Long-term effects of subarachnoid hemorrhage on blood-bran barrier integrity and cerebral perfusion flow. Proceedings: Society for Neuroscience, 35h Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 468.10. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.155 Mdzinarishvili,A., Kiewert, C., Bickel, U., Van der Schyf, C.J., Abbruscato, T., Klein, J. Evaluation of neuroprotective effects by bilobalide and hyperforin in the MCAO murine stroke model. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 548.12. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.156 Malan, S.F., Grobler, E., Grobler,A.F., Geldenhuys, W.J., Van der Schyf, C.J. Influence of pentacycloundecylamine derivatives on neuronal calcium homeostasis. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 1018.20. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.157 Geldenhuys, WJ., Klorig, D.C., Malan, S.F., Bloomquist, J.R., Van der Schyf, C.J. Pharmacological evaluation of adamantane amines that bind to the PCP and not the MK-801 binding site in the N-methyl-D-aspartate receptor. Proceedings: Society for Neuroscience, 3 5 th Annual Meeting, Washington, DC, November 12-16, 2005. Program No. 1020.5. 2005 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2005. Online. 5.158 Van der Schyf C.J. Cleaning the Face of the "Dirty Drug" - A new Concept in Drug Discovery. Invited Lecture in honor of the retirement of Dr. Neal Castagnoli, Department of Chemistry and Virginia/Maryland

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Regional College of Veterinary Medicine (VMRCVM), and sponsored by: Peters Center for the Study of Parkinson's Disease & VMRCVM, January 6, 2006. Blacksburg, VA. 5.159 Fr6d6ric, R., Ooms, F., Castagnoli, N., Jr., Petzer, J.P., Feng. J.-F., Schwarzschild, M.A., Van der Schyf, C.J., and Wouters, J. (2006) (E)-8-(3- chlorostyryl)-1,3-7-trimethylxanthine, a caffeinyl derivative acting both as antagonist of adenosine A2A receptors and inhibitor of MAO-B. Chemlnform, 37, pp. DOI: 10.1002/chin.200603164. 5.160 Gaasch, J.A., Geldenhuys, W.J., Lockman, P.R., Allen D.D., and Van der Schyf C.J. Iron entry into neuronal cells via the L-type calcium channel in an in vitro model of iron overload. Proceedings: "Senescence", Program #GP8, 18 th Annual Texas Tech University HSC Student Research Week, Lubbock, TX, February 13-17, 2006. 5.161 Kiewert, C., Van der Schyf, C.J., Hartmann, J., Stoll, J., Thekkumkara, T.J., and Klein, J. The polycyclic amine NGP1-01 is a brain-permeable dual calcium channel blocker. Proceedings: "Senescence", Program #GP14, 18 th Annual Texas Tech University HSC Student Research Week, Lubbock, TX, February 13-17, 2006. 5.162 Lockman, P.R., McAfee, G., Geldenhuys, W.J., Van der Schyf, C.J., Abbruscato, T.J. and Allen, D.D. Experimental and Mathematical Modeling of the Blood to Brain Transfer of Nicotine and Cotinine. Proceedings: 12th Annual SRNT Meeting. Society for Research on Nicotine and Tobacco. February 15-18, 2006. Orlando, FL. 5.163 Van der Schyf, C.J., Petzer, J.P., Castagnoli, K.P., Chen, J.-F., Schwarzschild, M.A., Castagnoli, N., Jr., Dual-Mechanism MAO-B inhibitors and A2a antagonists in Parkinson's Disease Therapy. Invited Plenary Lecture, MEDI 175: Current and Future Potential Drug Therapies for Parkinson's Disease; Proceedings: 231st American Chemical Society National Meeting, March 26-30, 2006. Atlanta, GA. 5.164 Gaasch, J.A., Nelson, L.G., Bohn, K.A., Egbert, J.M., Lockman, P.R., Van der Schyf, C.J. Differential toxic responses to iron overload by neuronal, brain endothelial, and astrocytic cells in vitro: Protection by L-type calcium channel blockers. Abstract #23, Abstracts: 5th Annual Research Days TTUHSC School of Pharmacy, July 2-4, 2006, Amarillo, Texas. 5.165 Gaasch, J.A., Lockman, P.R., Geldenhuys, WJ., Allen, D.D., Van der Schyf, C.J. Differential toxic responses to iron overload by neuronal, brain endothelial, and astrocytic cells in vitro: protection by the L-type calcium channel blocker nimodipine. Proceedings: Society for Neuroscience, 3 6 th Annual Meeting, Atlanta, GA, October 14-18, 2006. Program No. 502.7. 2006 Abstract Viewer/ItineraryPlanner. Atlanta, GA: Society for Neuroscience, 2006. Online. 5.166 Geldenhuys, WJ., Gaasch, J.A., Lockman, P.R., Van der Schyf, C.J., Allen, D.D. KCI-stimulated iron uptake in PC12 cells is blocked by nimodipine. Proceedings: Society for Neuroscience, 3 6 th Annual Meeting, Atlanta, GA, October 14-18, 2006. Program No. 91.11/NN40. 2006 Abstract Viewer/ItineraryPlanner. Atlanta, GA: Society for Neuroscience, 2006. Online.

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5.167 Lockman, P.R., Manda, V.K., Van der Schyf, C.J., Egbert, J.A., Dwoskin, L.P., Crooks, P.A., Allen, D.D. Determination of novel nicotinic receptor antagonist binding to the blood-brain barrier choline transporter: a potential mechanism for brain entry. Proceedings: Society for Neuroscience, 3 6 th Annual Meeting, Atlanta, GA, October 14-18, 2006. Program No. 460.13/EEl 1. 2006 Abstract Viewer/Itinerary Planner. Atlanta, GA: Society for Neuroscience, 2006. Online. 5.168 Van der Schyf, C.J. What's New in the Treatment of Adult Depression? Invited Lecture. Third Annual Family Medicine Clinical Update & Alumni Reunion, October 25, 2006, Northeastern Ohion Universities College of Medicine Ralph Regula Conference Center, Rootstown, OH. 5.169 Van der Schyf, C.J. A Multiple Disease Etiology Approach to Drug Discovery for Neu rodegeneration. Invited Lecture. Third Neurotoxicity Society Meeting: "Neurochemical Mechanisms for Neurodegenerative Disorders", March 23-25, 2007, Pucon, Chile. 5.170 Geldenhuys, W.J., Bezuidenhout, L.-M., Malan, S.F., Van der Schyf, C.J. GLUT-4 translocation facilitating activity of flavonoids from Cephalotaxus sinensis on mice adipocytes. Proceedings: 2 3 3 rd ACS National Meeting and Exposition, Chicago, IL, March 25-29, 2007: Abstracts of Papers of the American Chemical Society, 233, 865-865, Meeting Abstract: 197- MEDI, March 25, 2007. 5.171 Bezuidenhout, L.-M., Liebenberg, W., Malan, S.F., Van der Schyf, C.J. Polycyclic amine derivatives: The synthesis of triquinylamines as calcium modulators. Proceedings: 2 3 3 rd ACS National Meeting and Exposition, Chicago, IL, March 25-29, 2007. Program No. MEDI 323. 5.172 Geldenhuys, W.J., Bezuidenhout, L.-M., Malan, S.F., Van der Schyf, C.J. Computational investigation on the reductive amination of pharmacologically important triquinanes. Proceedings: 2 3 3rd ACS National Meeting and Exposition, Chicago, IL, March 25-29, 2007. Program No. MEDI 179. 5.173 Van der Schyf, C.J. A New Paradigm for Drug Discovery Research. Invited Lecture. 2007 KSU Biomedical Sciences Research Conference, April 6, 2007, Kent State University, Kent, OH. 5.174 McGory, R., Hartung, P.J., Allen, L.G., Cudnik, M.L., Gallegos, P.J., MacKichan, J.J., Van der Schyf, C.J., Allen, D.D. Interdisciplinary Longitudinal Curriculum for Pharmacy and Medical Students. Proceedings: AACP 2007 Annual Meeting and Seminars, "Celebrating Excellence", Disney's Yacht & Beach Club Resort, Lake Buena Vista, Florida, July 14-18, 2007. 5.175 McGory, R., MacKichan, J.J., Van der Schyf, C.J., Penn, M.A., Allen, D.D. A Staged Interdisciplinary Curriculum to Optimize Pharmaceutical Care. Proceedings: AACP 2007 Annual Meeting and Seminars, "Celebrating

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Excellence", Disney's Yacht & Beach Club Resort, Lake Buena Vista, Florida, July 14-18, 2007. 5.176 Van der Schyf, C.J. Invited Discussion Leader. Department Chairs Roundtable Session, Theme: Teaching. Proceedings: AACP 2007 Annual Meeting and Seminars, "CelebratingExcellence", Disney's Yacht & Beach Club Resort, Lake Buena Vista, Florida, July 14-18, 2007.

5.177 Van der Schyf, C.J. Adenosine A 2a Antagonist-MAO-B Inhibitors as Neuroprotectants. Invited Lecture. 2007 Recent Therapeutic Advances in Parkinson's and Alzheimer's Diseases, A Celebration Symposium honoring Professor Moussa Youdim's 45 Years in Science, Haifa, Israel, October 8-10, 2007. 5.178 Van der Schyf, C.J. Gerntegreerde Mediese en Aptekerskurrikula aan 'n Amerikaanse Universiteit: Ook 'n geleentheid vir Bilaterale SANSA Opleiding? (Afrikaans) Invited Lecture. 2007 Faculty of Health Sciences, North-West University, Potchefstroom, South Africa, October 16, 2007. 5.179 Van derSchyf, C.J. The Future of Multiple Mechanism Drugs as a Drug Discovery Paradigm Invited Lecture. 2007 School of Pharmacy, North- West University, Potchefstroom, South Africa, October 17, 2007. 5.180 Hao, J., Mdzinarishvili,A., Abbruscato, T.J., Klein, J., Van der Schyf, C.J., Bickel, U. Neuroprotective effects of NGP1-01 after transient brain ischemia in mice. Proceedings: Society for Neuroscience, 3 7 th Annual Meeting, San Diego, CA, November 3-7, 2007. Program No. 448.9. 2007 Abstract Viewer/Itinerary Planner.San Diego, CA: Society for Neuroscience, 2007. Online. 5.181 Van der Schyf, C.J. Collaborative research at NEOUCOP: Introduction and research initiatives. Invited Lecture. 2008 Research Symposium: The State of Research at Akron General Medical Center with Future and Current Initiatives. Health and Wellness Center West, Akron, OH, January 25, 2008. 5.182 Van der Schyf, C.J. Drug delivery challenges to the brain: Disease modifying drugs in neurodegeneration. Invited Lecture. USAF Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, OH, April 21,2008. 5.183 Lerner, D., Bezuidenhout, L.-M., Geldenhuys, W.J., and Van der Schyf, C.J. Novel Multimodal Calcium Blockers as Potential Stroke Therapies. Proceedings: American Neurological Association 133rd Annual Meeting, Salt Lake City, Utah, September 21-24, 2008. Program # M-48, Annals of Neurology, 2008, 64, S12. 5.184 Van der Schyf, C.J. Successful collaboration: A case study. Invited Lecture. 2009 Research Symposium: The State of Research at Akron General Medical Center with Future and Current Initiatives. Health and Wellness Center West, Akron, OH, January 23, 2009.

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5.185 Nedashkivska, V., Lyuksyutov, S., Bezuidenhout, L. -M., Van der Schyf, C.J. Electrostatic perturbation in neurons and endothelial cells under stress using Atomic Force Microscopy-assisted Electrostatic Nanolithography. Proceedings: American Physical Society, 2009 March Meeting, March 16-20, 2009; Pittsburgh, PA. Abstract: K1.00298, http.:/lmeetings.aps.org/link/BA PS.2009. MAR. K1. 298 5.186 Van der Schyf, C.J. Mitochondrial-linked neurodegeneration: drug discovery opportunities. Invited Lecture. IV. Neurotoxicity Society Meeting: Neurochemical Mechanisms of Neurodegenerative Disorders. Arica, Chile, April 24-26, 2009. Program page No. 29. Final Program& Abstracts. 5.187 McGory, R., Hart, J., Bruce, S.P., Van der Schyf, C.J., Allen, D.D. Use of Chat Rooms to Facilitate Faculty Discussions. Proceedings: 110th Annual Meeting of the American Association of Colleges of Pharmacy, Boston, Massachusetts, July 18-22, 2009, published in the American Journalof PharmaceuticalEducation 2009; 73 (4) Article 57, 93. 5.188 Bezuidenhout, L.-M., Geldenhuys, WJ., Malan, S.F., Van der Schyf, C.J., Neuroprotective strategies: Lipohilic pentacycloundecylamines and triquinylamines regulate calcium homeostasis in PC12 cells. Proceedings:

Society for Neuroscience, 3 9 th Annual Meeting, Chicago, IL, October 17- 21, 2009. Program No. 153.6/M4. 2009 Abstract Viewer/Itinerary Planner. Chicago, IL: Society for Neuroscience, 2009. Online. 5.189 Mittapalli, R.K., Geldenhuys, WJ., Manda, V.K., Van der Schyf, C.J., Crooks, P.A., Dwoskin, L.P., Allen, D.D., Lockman, P.R. Predictive Screening Model For Potential Vector-Mediated Transport of Cationic Substrates at the Blood-Brain Barrier Choline Transporter. Abstracts (Abstract# W4191): 2009 AAPS Annual Meeting and Exposition, November 8 - 12, 2009, Los Angeles, CA. 5.190 Van der Schyf, C.J. Pharmaceutical Sciences Research in Northeast Ohio: A Collaborative Opportunity. Invited Lecture. 2010 Cleveland Symposium on Pharmaceutical Sciences, Cleveland, Ohio, April 30, 2010. 5.191 Van der Schyf, C.J. Multi-targeted Drugs for Neurodegenerative Diseases and Stroke: Pharmacological and Chemical Challenges. Invited Lecture. Institut fOr Pharmakologie, Johann Wolfgang Goethe-Universittt Frankfurt, Germany, May 11,2010. 5.192 Van der Schyf, C.J. Multi-mechanism drugs for neurodegenerative diseases and post-stroke neuroprotection. Invited Plenary Lecture. 28th Camerino-Cyprus-Noordwijkerhout Symposium. Camerino, Italy, May 16- 20, 2010. Trekking through Receptor Chemistry. European Federation of Medicinal Chemistry & Medicinal Chemistry Division of the Italian Chemical Society.

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5.193 Van der Schyf, C.J. Discovery is Driven by Curiosity, Creativity and Solid Data. Invited Lecture. Dexa Academy of Science, "Science and Scientists in the Dexa Medica Group", July 27, 2010. Jakarta, Indonesia. 5.194 Van der Schyf, C.J. Evidence-based Drug Discovery Processes. Invited Lecture. Dexa Academy of Science, "Science and Scientists in the Dexa Medica Group", July 27, 2010. Jakarta, Indonesia. 5.195 Van der Schyf, C.J. The New Drug Discovery: Creative Molecular Templates and Multiple Pathological Targets. Invited Lecture. Dexa Laboratories of Biomolecular Sciences (DLBS), July 28, 2010. Jababeka, Cikarang, Indonesia. 5.196 Terre'Blanche, G., Heyer, N., Bergh, J.J., Mienie, L.J., Van der Schyf, C.J., Harvey, B.H. Behavioural and neurochemical evidence for striatal toxicity in rats treated with phenylglyoxylic acid, a metabolite of styrene. Proceedings: South African Congress for Pharmacology and Toxicology 2010, October 3-6, 2010; Cape Town, South Africa. Abstract: PP17, http://www. sapharmacoL co. za/CONGRESS Site/html pages/Docs/abstr20lO.pdf 5.197 Kidd, S., Lehotsky, K., Geldenhuys, W.J., Van der Schyf, C.J. Synthesis of oxa- and aza-pentacycloundecane derivatives as neuroprotective agents. Proceedings: Keystone Symposium - NeurodegenerativeDiseases: The Molecular and CellularBasis for Neurodegeneration,Program # 225, p. 85, February 21 - 26, 2011. Sagebrush Inn and Conference Center, Taos, New Mexico. 5.198 Crish, S.D., Braymer, J.J., Geldenhuys, WJ., Van der Schyf, C.J., Lim, M.H. Decreased metal ion levels in the DBA/2J mouse model of glaucoma. Proceedings: Cleveland State University College of Sciences and Health Professions Research Day 2011, Program # 086, April 15, 2011, Cleveland, Ohio. 5.199 Van der Schyf, C.J. High Resolution Tandem Mass Spectrometry in the Drug Development Process: a NEOMED approach. Invited Seminar. Proceedings: New Developments in Clinical Research Using LC/MS/MS. An ABSciex Research Symposium, September 22, 2011, Rootstown, Ohio. 5.200 Darvesh, A.S., Geldenhuys, WJ., Jones, T.J., Carroll,R.T., Van der Schyf, C.J., Dluzen, D.E. Adrenergic receptors modulate methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice. Proceedings: Society for Neuroscience, Neuroscience 2012, New Orleans, LA, October 13 - 17, 2012. Program No. 360.08/Z4. 2012 Abstract Viewer/Itinerary Planner.New Orleans, LA: Society for Neuroscience, 2012. Online. 5.201 Crish, S.D., Braymer, J.J., DeToma, A.S., Van der Schyf, C.J., Lim, M.H. Decreased metal ion levels in the DBA/2J mouse model of glaucoma. Proceedings: Society for Neuroscience, Neuroscience 2012, New Orleans, LA, October 13- 17, 2012. Program No. 163.19/Q8. 2012

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Abstract Viewer/Itinerary Planner.New Orleans, LA: Society for Neuroscience, 2012. Online. 5.202 Van der Schyf, C.J. Chemical manipulation of polycyclic cage compounds: creating multi-target ligands as drug candidates. Invited Lecture. 2012 Chemistry Department, College of Sciences and Health Professions, Cleveland State University Seminar Series, Cleveland, OH, November 9, 2012. 5.203 Van der Schyf, C.J. Axonopathy in Retinal Neurodegeneration: Seeing past the eye. Invited Plenary Lecture. Proceedings: VI Neurotoxicity Society Meeting: Mechanisms of neurodegenerative disorders, March 21- 24, 2013, Valdivia, Chile (could not attend - cancelled at last minute). 5.204 Coughlin, L., Geldenhuys, W.J., Van der Schyf, C.J., Mdzinarishvili, A. Proneurogenic effects of NGP1 -01, a polycyclic cage amine. Proceedings: Society for Neuroscience, Neuroscience 2013, San Diego, CA, November 9-13, 2013. Program No. 314.02/A2. 2013 Abstract Viewer/Itinerary Planner.SanDiego, CA: Society for Neuroscience, 2013. Online. 5.205 Van der Schyf, C.J. Metals in the brain impact neural degeneration, cognition and perception. Invited Lecture. 2014 Department of Psychology, College of Arts and Letters, Idaho State University Colloquium Series, Pocatello, ID, October 15, 2014.

6. Journal Editorials 6.1 Van der Schyf, C.J. and Youdim, M.B. Multifunctional drugs as neurotherapeutics. Neurotherapeutics,2009, 6, 1-3. 6.2 Van der Schyf, C.J. The use of multi-target drugs in the treatment of neurodegenerative diseases. Expert Review of Clinical Pharmacology, 2011, 4, 293-298.

7. Invited Forewords to Books 7.1 Van der Schyf, C.J. in: Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases, 1st Edition by Christophe Wiart, Academic Press, ISBN: 9780123983732, January 2014, xiii-xiv.

8. Confidential Reports to Industry 8.1 Van der Schyf, C.J., et al., "Calcium Antagonists", 7 expert reports to Noristan Research Ltd., Waltloo, Pretoria, South Africa, 1986-1988. 8.2 Van der Schyf, C.J., et al., "Cardiovascular Drug Design", 3 expert reports to South African Druggists Ltd., Port Elizabeth, South Africa, 1992-1993. 8.3 Van der Schyf, C.J., Malan, S.F., and De Villiers, M., "Paracetamol (Acetaminophen) Hepatotoxicity and Protection Strategies", 3 expert reports to South African Druggists Ltd., Port Elizabeth, South Africa, 1995- 1996.

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9. Own Dissertations 9.1 Van der Schyf, C.J.; Synthesis and Enantiomer Separation of a Number of Polycyclic Ketones, M.Sc. Dissertation, Potchefstroom University, 1981. 9.2 Van der Schyf, C.J.; The Synthesis and Structure-Activity Relationship of a Series of Antimicrobial Compounds, D.Sc. (Ph.D.) Dissertation, Potchefstroom University, 1983.

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