Lecture 1 Pharmacophores & Molecular Similarity
Invited Guest Professorship Université Lois Pasteur, Strasbourg
Prof. Dr. Gisbert Schneider Goethe-University, Frankfurt
18 November 2008, (c) G. Schneider Transmutation of species
“[..] Thus between A & B immense gap of relation. C & B the finest gradation, B & D rather greater distinction. Thus genera would be formed. — bearing relation”
Charles R. Darwin (*1809) Notebook B: Transmutation of Species (1837-1838), p.36 Source: www.darwin-online.org.uk 3 Representations of Aspirin®
8 9 HO O 7 6 10 O 12 1 5 11 OH 2 4 13 3
4 Discrete Approximation: Atom