New Products

Fall 2014

...where molecules become real TM

Fall 2015 New Products

Phospholipid & Membrane Improved Molecules of Life © Transport Kit© Collection now with Aquaporin Page 5 Protein Model Flow of Genetic Information Kit© Page 12 Page 13

Dopamine and Serotonin New Aquaporin Mini Model Biosynthesis Models Page 4 Page 21

Also see our new Science Olympiad Protein Modeling Event Kits Page 20

Our Customers' Favorite Products

Water Kit© Amino Acid Starter Kit© Enzymes in Action Kit© DNA Discovery Kit© Page 3 Page 7 Page 8 Page 11

Also see David Goodsell Cellular Landscapes Page 15

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Contents Consumer Product Safety Warnings ...... 2 Mitochondria Poster© ...... 15 Water Kit© and NaCl Lattice© ...... 3 E. coli Poster© ...... 15 Channel Protein Mini Models: Sodium Channel, Synapse Poster© ...... 15 Aquaporin Channel, Potassium Channel, Potassium Nucleosome Mini Model ...... 16 Channel Bound with Scorpion Toxin ...... 4 Large and Small Ribosome Mini Models ...... 16 Phospholipid & Membrane Transport Kit© ...... 5 Transfer RNA (Plaster & Nylon) Phospholipid Modeling Set ...... 5 Mini Models ...... 16 ß-Globin Folding Kit© & Prefolded Model©...... 6 Antibody (Plaster & Nylon) Mini Models ...... 17 ß-Globin Mini Models ...... 6 Hemagglutinin Mini Model ...... 17 Paper BioInformatics Influenza Virus Capsules ...... 17 Map of Human ß-Globin Gene© ...... 6 The Data Dilemma©...... 18 Amino Acid Starter Kit© & Poster ...... 7 Mystery Tube© ...... 18 Enzymes In Action Kit© ...... 8 Modeling Mini Toobers ...... 18 Acetylcholinesterase Active Site Cube ...... 8 Amino Acid Building Block Models ...... 19 3DMD Genetic Codon Posters© ...... 8 Green Fluorescent Protein Mini Model ...... 19 Insulin mRNA to Protein Kit© & Poster ...... 9 Zinc Finger Mini Model ...... 19 Insulin Mini Model ...... 9 Water Tattoos ...... 19 Hemoglobin Nylon Model & Poster ...... 10 Science Olympiad DNA Mini Model ...... 10 Protein Modeling Event Kits ...... 20 Adenosine Triphosphate Mini Model ...... 10 Neurotransmitters Module: The Beery Twins' Story© DNA Discovery Kit© ...... 11 Human Sepiapterin Reductase mRNA GeneMap© DNA Starter Kit© & Expansion Pack ...... 11 Dopamine and Serotonin Biosynthesis Models . 21 Molecules of Life Collection© ...... 12 Next Generation Science Standards ...... 22 Flow of Genetic Information Kit© ...... 13 Connections to A Framework For Demo DNA Nucleotides© ...... 13 K-12 Science Education ...... 22 Alpha Helix & Beta Sheet Models ...... 14 Index by Catagory ...... 24 Alpha Helix & Beta Sheet Construction Kit© . . . . 14 Order Form ...... 25 Tour of a Human Cell Panorama© ...... 15

Nearly all of the models and kits in this catalog were initially Through 3D Molecular Designs’ research, development and field developed by Tim Herman, PhD, Director of the Milwaukee testing — led by partners, Tim and Diane Herman and Heather School of Engineering (MSOE) Center for BioMolecular Ryan, Director of Operations — model and kit prototypes become Modeling (CBM), an instructional materials laboratory. Tim the durable products you see in this catalog. The company has Herman is assisted by Program Directors Margaret Franzen, received Small Business Innovative Research Grants from the PhD, Gina Vogt, MS, and Diane Munzenmaier, PhD, Lead National Institutes of Health and National Science Foundation to Designer Mark Hoelzer, and more than 300 high school and assist with the development of some products. college educators who have attended CBM summer courses, workshops and/or field tested prototypes. CBM programs are supported by grants from the NIH SEPA program and the NSF DUE program.

3D Molecular Designs utilizes magnets in many products to help students understand the inter- and intra-molecular forces in the molecular world. In compliance with the Consumer Product Safety Improvement Act of 2008, 3DMD adds the warnings below to our products and encourages the safe use of our products in classrooms and other science education settings. Please contact us if you have questions or concerns.

! WARNING: SMALL MAGNETS ! WARNING: CHOKING HAZARD CAUTION: This product contains small magnets. Swallowed magnets can stick This product contains small parts and should be kept out of the reach This is a science education together across intestines causing serious infections and death. Seek of children under the age of 3, because the parts or their pieces may product, not a toy. It is not intended immediate medical attention if magnets are swallowed or inhaled. present a choking hazard to small children. for children under 8 years old.

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WinterFall 2015 2015 Water Kit© While playing with these appealing magnetic water molecules your students will understand concepts that are often difficult to learn. They will explore hydrogen bonding, make ice, dissolve salt, evaporate water, explore transpiration, create ethanol and much more. Each Water Kit© cup includes pieces for 12 water molecules, 1 sodium, 1 chloride, 1 ethane and 1 hydroxyl group. All atoms are magnetized to reflect their positive or negative charges (except for non-polar ethane). Lessons and activities are available online. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

10-Cup Set $385 (WK-10) • 8-Cup Set $308 (WK-08) • 6-Cup Set $232 (WK-06) 2 to 5 Cups $42 each (WK-02) • 1-Cup $44 (WK-01) Also see Aquaporin Mini Model (page 4), Phospholipid & Membrane Transport Kit© (page 5), and Water Tattoos (page 19).

! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS

CAUTION: Science Education Product Please see bottom of page 2 for details.

See our Phospholipid & Membrane Transport Kit© (page 5)!

NaCl Lattice© Your students will discover the cubic nature of salt crystals, efficient lattice packing, high melting temperature, brittleness, cleavage planes and more with these models. Each ion model has 6 embedded magnets to simulate ionic bonding. The 4x4x4 lattice contains 64 ions (32 sodium and 32 chloride) and the 3x3x3 lattice contains 27 ions (13 of 1 type of ion and 14 of the other). Lattices do not include 3DMD water molecules. Water molecules are sold in Water Kits© (see above). See Connections to A Framework for K-12 Science Education (pages 22 & 23). 3x3x3 Lattice 4x4x4 Lattice 4x4x4 Lattice $177 (NACL-04) 3x3x3 Lattice $82 (NACL-03)

Also see Sodium Channel and Potassium Channel ! WARNING: CHOKING HAZARD Mini Models (page 4). ! WARNING: SMALL MAGNETS

CAUTION: Science Education Product Please see bottom of page 2 for details.

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Channel Protein Mini Models

Sodium Channel Mini Model Voltage-gated sodium channels play a critical role in generating the action potential in signaling neurons. As they open — in response to an approaching action potential — sodium ions enter the cell, leading to depolarization and a continuation of the action potential. This model of a bacterial sodium channel shows the pore domain of the protein, not the domain responsible for sensing the voltage across the membrane. The pore domain of the sodium channel is a homo- tetramer in which 4 identical proteins come together to form the ion pore — exposed on the outside surface of the cell. The protein was captured in its open conformation, where your students can easily see how Na+ ions can be released into the cytoplasm after passing through the pore. © © Also see Water Kit and NaCl Lattice (page 3). 3.75” Plaster Model $95 (SCMM)

Aquaporin Channel Mini Model Aquaporin — a membrane-spanning protein — is responsible for moving water across a lipid bilayer. Its structure consists of 6 alpha helices and 2 half alpha helices that form an hourglass shape through which water molecules move one at a time. Two asparagine amino acids are strategically positioned at the narrowest point of the hourglass and provide selectivity to this channel, allowing only water molecules pass through.

3.75” Plaster Model $77 (ACMM) Also see Water Kit© (page 3). The Aquaporin Mini Model opens to show water molecules rolling over in their passage through the channel.

Potassium Channel Mini Model The potassium channel is a 4-subunit, transmembrane protein that allows the rapid passage of potassium ions — but not sodium ions — across the membrane. The protein backbones of the 4 subunits come together to form a channel, with carbonyl oxygen atoms precisely positioned in 3-D space to replace the water that normally hydrates each ion. Since there is no energetic difference between a hydrated potassium ion and the same ion bound in the pore of the potassium channel, the ion rapidly passes through the channel in a frictionless manner.

3.75” Plaster Model $78 (PCMM) Also see NaCl Lattice© (page 3).

Potassium Channel Bound with Scorpion Toxin Mini Model These 2 models enable you to tell many stories. The green potassium channel model illustrates how this amazing protein allows the rapid transport of potassium channel ions while simultaneously preventing the flow of smaller sodium ions. The yellow scorpion toxin model (from the Chinese scorpion Buthus martensi) shows how disulfide bonds stabilize the structure of this small protein, how some proteins interact to form multi-protein complexes, and how a strategically placed lysine side chain of the magnet-docked scorpion toxin plugs the channel through which potassium ions normally flow. The model also displays additional amino acid side chains that are important in stabilizing the interaction between these 2 proteins.

5'' Plaster Model $87 (PCSMM)

Channel protein mini models are built at the same scale.

Mini models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23). Page 4 3dmoleculardesigns.com

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FallWinter 2015 2015 Price Drop Phospholipid & Membrane Transport Kit© Let your students discover the spontaneous formation of membranes for themselves, using this new kit that features the amphipathic structure of phospholipids, with their hydrophilic heads and hydrophobic tails. Your students will explore the chemical structure of a phospholipid and then construct a phospholipid monolayer, a micelle and a bilayer, leading to an understanding of the plasma membrane structure. Additional components of this kit allow students to construct lipid bilayers and consider the role of transport proteins in moving ions and small molecules across membranes. Lessons and activities are available online. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

1-Group Set $38 (PMTK-01) © Also see Water Kit (page 3). ! WARNING: CHOKING HAZARD CAUTION: Science Education Product Please see bottom of page 2 for details.

New Phospholipid Modeling Set These Molymod phospholipid models enable your students to explore the amphipathic structure of phospholipids, the most abundant lipids in membranes. The set contains all of the atoms and bonds needed to construct five phospholipids: phosphatidylcholine, phosphatidylserine, phosphatidylinositol, phosphatidylethanolamine and sphingomyelin, and Phosphatidylinositol Phosphatidylcholine Sphingomyelin compare and contrast the chemical make-up of their hydrophilic heads and hydrophobic tails. The phospholipid models can be used separately or with the Phospholipid & Membrane Transport Kit©.

Phospholipid Modeling Set $507 (PLMS-01) Phosphatidylcholine $114 (PLMS-A) Phosphatidylserine $109 (PLMS-B) Phosphatidylinositol $119 (PLMS-C) Indicates Double Bond Phosphatidylethanolamine $106 (PLMS-D) Sphingomyelin $118 (PLMS-E) Also see Water Kit© (page 3) and Phospholipid & Membrane ! WARNING: CHOKING HAZARD Transport Kit© (above). CAUTION: Science Education Product Please see bottom of page 2 for details. Phosphatidylethanolamine Phosphatidylserine

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β-Globin Folding Kit© Proteins become real in your students’ hands as they fold 3 mini toober β-globin fragments and discover the primary, secondary and tertiary structure in this model. Maps guide your students in folding the mini toobers into β-globin’s 3-D shape. Use the folded mini toober model of β-globin to discuss protein structure, the important role of hemoglobin in oxygen transport and the lasting effects of a single amino acid mutation on a protein. The kit includes mini toobers, folding map guides, amino acid side chains, heme group, iron atom, oxygen atoms and an assortment of parts to mark and connect the fragments. Teacher notes and student handouts are available online. The folding kit can be used successfully by 6 to 9 students working in 3 teams. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

Folding Kit $118 (BGFK) Prefolded Model $120 (BGM) ! WARNING: CHOKING HAZARD It’s best if your students first use the Amino Acid Starter Kit© (page 7) before using the CAUTION: Science Education Product β-Globin Folding Kit©. Also see Map of the Human β-Globin Gene© (below). The prefolded Please see bottom of page 2 for details. model can be used as a same-scale model when using the β-Globin Folding Kit© or to teach concepts noted above.

β-Globin Mini Models β-globin, a small protein (146 amino acids), transports oxygen throughout our bodies. Our 2 β-Globin Mini Models feature the heme group with its iron atom which binds oxygen, the location of the sickle cell mutation and selected charged, hydrophobic and hydrophilic side chains. The model on the left can be used as an accurate, smaller-scale template when using the β-Globin Folding Kit© (above). The 3 colors correspond to the 3 fragments in the β-Globin Folding Kit©. Side chains on the model on the right indicate mutations that are noted on the Teacher Map of the Human β-Globin Gene© (below). The 3 colors of the alpha carbon backbone correspond to the 3 exons in the gene. Mini models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to Use with β-Globin Folding Kit© A Framework for K-12 Science Education (pages 22 & 23). 4” Plaster Model $74 (BGMMFK) • 4” Plaster Model $74 (BGMMPBI) Also see β-Globin Folding Kit© (above) and Teacher Map of the Human β-Globin Gene© (below).

Use with Map of the Human β-Globin Gene©

Map of the Human β-Globin Gene© A 3DMD BioInformatics Activity©

β-Globin mRNA A begins here. EXON I -75 CAAT Box -25 TATA Box T A A A Reduced level of β-Globin protein is made due to inefficient donor splice site (β+ thalassemia). EXON II AGCCAGTGCCAGAAGAGCCAAGGACAGGTACGGCTGTCATCACTTAGACCTCACCCTGTGGAGCCACACCCTAGGGTTGGCCAATCTACTCCCAGGAGCAGGGAGGGCAGGAGCCAGGGCTGGGCATAAAAGTCAGGGCAGAGCCATCTATTGCTT ACATTTGCTTCTGACACAACTGTGTTCACTAGCAACCTCAAACAGACACCATGGTGCACCTGACTCCTGAGGAGAAGTCTGCCGTTACTGCCCTGTGGGGCAAGGTGAACGTGGATGAAGTTGGTGGTGAGGCCCTGGGCAGGTTGGTATCAAGGTTACAAGACAGGTTTAAGGAGACCAATAGAAACTGGGCATGTGGAGACAGAGAAGACTCTTGGGTTTCTGATAGGCACTGACTCTCTCTGCCTATTGGTCTATTTTCCCACCCTTAGGCTGCTGGTGGTCTACCCTTGGACCCAGAGGTTCTTTGAGTCCTTTGGGGATCTGTCCACTCCTGATGCTGTTATGGGCAACCCTAAGGTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGACAACCTCAAGGGCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTGCACGTGGATCCTGAGAACTTCAGGGTGAGTCTATGGGACCCTTGATGTTTTCTTTCCCCTTCTTTTCTATGGTTAAGTTCATGTCATAGGAAGGGGAGAAGTAACAGGGTACAGTTTAGAATGGGAAACAGACGAATGATTGCATCAGTGTGGAAGTCTCAGGATCGTTTTAGTTTCTTTTATTTGCTGTTCATAACAATTGTTTTCTTTTGTTTAATTCTTGCTTTCTTTTTTTTTCTTCTCCGCAATTTTTACTATTATACTTAATGCCTTAACATTGTGTATAACAAAAGGAAATATCTCTGAGATACATTAAGTAACTTAAAAAAAAACTTTACACAGTCTGCCTAGTACATTACTATTTGGAATATATGTGTGCTTATTTGCATATTCATAATCTCCCTACTTTATTTTCTTTTATTTTTAATTGATACATAATCATTATACATATTTATGGGTTAAAGTGTAATGTTTTAATATGTGTACACATATTGACCAAATCAGGGTAATTTTGCATTTGTAATTTTAAAAAATGCTTTCTTCTTTTAATATACTTTTTTGTTTATCTTATTTCTAATACTTTCCCTAATCTCTTTCTTTCAGGGCAATAATGATACAATGTATCATGCCTCTTTGCACCATTCTAAAGAATAACAGTGATAATTTCTGGGTTAAGGCAATAGCAATATTTCTGCATATAAATATTTCTGCATATAAATTGTAACTGATGTAAGAGGTTTCATATTGCTAATAGCAGCTACAATCCAGCTACCATTCTGCTTTTATTTTATGGTTGGGATAAGGCTGGATTATTCTGAGTCCAAGCTAGGCCCTTTTGCTAATCATGTTCATACCTCTTATCTTCCTCCCACAGCTCCTGGGCAACGTGCTGGTCTGTGTGCTGGCCCATCACTTTGGCAAAGAATTCACCCCACCAGTGCAGGCTGCCTATCAGAAAGTGGTGGCTGGTGTGGCTAATGCCCTGGCCCACAAGTATCACTAAGCTCGCTTTCTTGCTGTCCAATTTCTATTAAAGGTTCCTTTGTTCCCTAA 62000 62050 62100 62150 62200 62206 62250 62265 62279 62283 62300 62350 62388 62400 62450 61981 ------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+------+ TCGGTCACGGTCTTCTCGGTTCCTGTCCATGCCGACAGTAGTGAATCTGGAGTGGGACACCTCGGTGTGGGATCCCAACCGGTTAGATGAGGGTCCTCGTCCCTCCCGTCCTCGGTCCCGACCCGTATTTTCAGTCCCGTCTCGGTAGATAACGAA TGTAAACGAAGACTGTGTTGACACAAGTGATCGTTGGAGTTTGTCTGTGGTACCACGTGGACTGAGGACTCCTCTTCAGACGGCAATGACGGGACACCCCGTTCCACTTGCACCTACTTCAACCACCACTCCGGGACCCGTCCAACCATAGTTCCAATGTTCTGTCCAAATTCCTCTGGTTATCTTTGACCCGTACACCTCTGTCTCTTCTGAGAACCCAAAGACTATCCGTGACTGAGAGAGACGGATAACCAGATAAAAGGGTGGGAATCCGACGACCACCAGATGGGAACCTGGGTCTCCAAGAAACTCAGGAAACCCCTAGACAGGTGAGGACTACGACAATACCCGTTGGGATTCCACTTCCGAGTACCGTTCTTTCACGAGCCACGGAAATCACTACCGGACCGAGTGGACCTGTTGGAGTTCCCGTGGAAACGGTGTGACTCACTCGACGTGACACTGTTCGACGTGCACCTAGGACTCTTGAAGTCCCACTCAGATACCCTGGGAACTACAAAAGAAAGGGGAAGAAAAGATACCAATTCAAGTACAGTATCCTTCCCCTCTTCATTGTCCCATGTCAAATCTTACCCTTTGTCTGCTTACTAACGTAGTCACACCTTCAGAGTCCTAGCAAAATCAAAGAAAATAAACGACAAGTATTGTTAACAAAAGAAAACAAATTAAGAACGAAAGAAAAAAAAAGAAGAGGCGTTAAAAATGATAATATGAATTACGGAATTGTAACACATATTGTTTTCCTTTATAGAGACTCTATGTAATTCATTGAATTTTTTTTTGAAATGTGTCAGACGGATCATGTAATGATAAACCTTATATACACACGAATAAACGTATAAGTATTAGAGGGATGAAATAAAAGAAAATAAAAATTAACTATGTATTAGTAATATGTATAAATACCCAATTTCACATTACAAAATTATACACATGTGTATAACTGGTTTAGTCCCATTAAAACGTAAACATTAAAATTTTTTACGAAAGAAGAAAATTATATGAAAAAACAAATAGAATAAAGATTATGAAAGGGATTAGAGAAAGAAAGTCCCGTTATTACTATGTTACATAGTACGGAGAAACGTGGTAAGATTTCTTATTGTCACTATTAAAGACCCAATTCCGTTATCGTTATAAAGACGTATATTTATAAAGACGTATATTTAACATTGACTACATTCTCCAAAGTATAACGATTATCGTCGATGTTAGGTCGATGGTAAGACGAAAATAAAATACCAACCCTATTCCGACCTAATAAGACTCAGGTTCGATCCGGGAAAACGATTAGTACAAGTATGGAGAATAGAAGGAGGGTGTCGAGGACCCGTTGCACGACCAGACACACGACCGGGTAGTGAAACCGTTTCTTAAGTGGGGTGGTCACGTCCGACGGATAGTCTTTCACCACCGACCACACCGATTACGGGACCGGGTGTTCATAGTGATTCGAGCGAAAGAACGACAGGTTAAAGATAATTTCCAAGGAAACAAGGGATT Donor Splice Site INTRON I Acceptor Splice Site a S Q C Q K S Q G Q V R L S S L R P H P V E P H P R V G Q S T P R S R E G R S Q G W A * K S G Q S H L L L T F A S D T T V F T S N L K Q T P W C T * L L R R S L P L L P C G A R * T W M K L V V R P W A G W Y Q G Y K T G L R R P I E T G H V E T E K T L G F L I G T D S L C L L V Y F P T L R L L V V Y P W T Q R F F E S F G D L S T P D A V M G N P K V K A H G K K V L G A F S D G L A H L D N L K G T F A T L S E L H C D K L H V D P E N F R V S L W D P * C F L S P S F L W L S S C H R K G R S N R V Q F R M G N R R M I A S V W K S Q D R F S F F Y L L F I T I V F F C L I L A F F F F L L R N F Y Y Y T * C L N I V Y N K R K Y L * D T L S N L K K N F T Q S A * Y I T I W N I C V L I C I F I I S L L Y F L L F L I D T * S L Y I F M G * S V M F * Y V Y T Y * P N Q G N F A F V I L K N A F F F * Y T F L F I L F L I L S L I S F F Q G N N D T M Y H A S L H H S K E * Q * * F L G * G N S N I S A Y K Y F C I * I V T D V R G F I L L I A A T I Q L P F C F Y F M V G I R L D Y S E S K L G P F A N H V H T S Y L P P T A P G Q R A G L C A G P S L W Q R I H P T S A G C L S E S G G W C G * C P G P Q V S L S S L S C C P I S I K G S F V 3 Forward 40 50 reading b A S A R R A K D R Y G C H H L D L T L W S H T L G L A N L L P G A G R A G A R A G H K S Q G R A I Y C L H L L L T Q L C S L A T S N R H H G A P D S * G E V C R Y C P V G Q G E R G * S W W * G P G Q V G I K V T R Q V * G D Q * K L G M W R Q R R L L G F * * A L T L S A Y W S I F P P L G C W W S T L G P R G S L S P L G I C P L L M L L W A T L R * R L M A R K C S V P L V M A W L T W T T S R A P L P H * V S C T V T S C T W I L R T S G * V Y G T L D V F F P L L F Y G * V H V I G R G E V T G Y S L E W E T D E * L H Q C G S L R I V L V S F I C C S * Q L F S F V * F L L S F F F F S A I F T I I L N A L T L C I T K G N I S E I H * V T * K K T L H S L P S T L L F G I Y V C L F A Y S * S P Y F I F F Y F * L I H N H Y T Y L W V K V * C F N M C T H I D Q I R V I L H L * F * K M L S S F N I L F C L S Y F * Y F P * S L S F R A I M I Q C I M P L C T I L K N N S D N F W V K A I A I F L H I N I S A Y K L * L M * E V S Y C * * Q L Q S S Y H S A F I L W L G * G W I I L S P S * A L L L I M F I P L I F L P Q L L G N V L V C V L A H H F G K E F T P P V Q A A Y Q K V V A G V A N A L A H K Y H * A R F L A V Q F L L K V P L frames c P V P E E P R T G T A V I T * T S P C G A T P * G W P I Y S Q E Q G G Q E P G L G I K V R A E P S I A Y I C F * H N C V H * Q P Q T D T M V H L T P E E K S A V T A L W G K V N V D E V G G E A L G R L V S R L Q D R F K E T N R N W A C G D R E D S W V S D R H * L S L P I G L F S H P * A A G G L P L D P E V L * V L W G S V H S * C C Y G Q P * G E G S W Q E S A R C L * * W P G S P G Q P Q G H L C H T E * A A L * Q A A R G S * E L Q G E S M G P L M F S F P F F S M V K F M S * E G E K * Q G T V * N G K Q T N D C I S V E V S G S F * F L L F A V H N N C F L L F N S C F L F F S S P Q F L L L Y L M P * H C V * Q K E I S L R Y I K * L K K K L Y T V C L V H Y Y L E Y M C A Y L H I H N L P T L F S F I F N * Y I I I I H I Y G L K C N V L I C V H I L T K S G * F C I C N F K K C F L L L I Y F F V Y L I S N T F P N L F L S G Q * * Y N V S C L F A P F * R I T V I I S G L R Q * Q Y F C I * I F L H I N C N * C K R F H I A N S S Y N P A T I L L L F Y G W D K A G L F * V Q A R P F C * S C S Y L L S S S H S S W A T C W S V C W P I T L A K N S P H Q C R L P I R K W W L V W L M P W P T S I T K L A F L L S N F Y * R F L C 1 2 3 4 5 6 7 8 9 10 20 30 Consensus Consensus Consensus C Consensus A T EXON INTRON INTRON EXON GG CAATCT TATA Box TATA T A A The first methionine amino acid is Note: all introns begin with GU and end with AG. Donor Splice Site Acceptor Splice Site CAAT Box ( T ) ( ) ( ) cleaved from the β-Globin protein This negatively charged V C A Promoter Region AG GU YYYYYYYYYNCAG G soon after its synthesis. glutamic acid (E) is A G replaced by a hydrophobic valine (V) in sickle cell anemia.

Don’t just tell your students about triplet codons, reading frames or introns and exons. Let them discover these eukaryotic gene features as they explore the Map of the Human β-Globin Gene©. Starting with the protein sequence, students work backward to discover the β-globin gene. Student maps can be used by individuals or small groups and are available in sets of 1, 3 or 12.

One teacher's map comes with every combo. The teacher's map features highlighted reading frames and mutation sites. Teachers' notes, instructions and student handout are provided. All maps are laminated. See Connections to A Framework for K-12 Science Education (pages 22-23).

1 Student and 1 Teacher Map Combo $40 (BGGM-01S-01T) • 3 Student and 1 Teacher Map Combo $60 (BGGM-03S-01T) 12 Student and 1 Teacher Map Combo $145 (BGGM-12S-01T)

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Fall 2015

Amino Acid Starter Kit© Your students will explore the primary, secondary and tertiary structure of proteins with this captivating kit. They will learn the chemical properties of the 20 amino acid side chains through a dual coloring scheme — a colored clip at the base of each side chain indicates chemical properties while embedded colored balls in side chain models show atomic structure. Understanding protein structure begins with this unique combination of atomic and chemical properties of the amino acids. Through the kit’s engaging, hands-on activities your students will gain a basic knowledge of protein folding before discovering the importance of secondary structure and active sites with additional folding activities. Each 1-group set includes 1 chemical properties circle, 1 amino acid side chain list, 22 amino acids, 1 4-foot mini toober, 15 plastic clips and 6 hydrogen bond connectors. Teacher notes, student handouts and interactive Jmol visualization tools are available online. Multiply each item by 3, 5 or 6 Easel not included. for the 3-group, 5-group and 6-group sets. See Connections to A Framework Additional side chains shown for K-12 Science Education (pages 22 & 23). Project Lead the Way© selected the Amino Acid Starter Kit© for its BioMedical Sciences™ Program.

6-Group Set $314 (AASK-06) 5-Group Set $263 (AASK-05) 3-Group Set $164 (AASK-03) 1-Group Set $61 (AASK-01)

Tertiary Structure Secondary Structure Active Site To increase your students’ understanding of proteins, see the ß-Globin Folding Kit© and Map of the Human ß-Globin Gene© (page 6), Insulin ! WARNING: CHOKING HAZARD mRNA to Protein Kit© (page 9), Ribosome Mini Models (page 16), Tour of CAUTION: Science Education Product a Human Cell©, Mitochondria Poster©, E. Coli Poster© and Synapse Poster© Please see bottom of page 2 for details. (page 15), Amino Acid Starter Kit Poster© (below) and Genetic Codon Posters© (page 8).

Amino Acid Starter Kit Poster© The Amino Acid Starter Kit Poster© allows students to connect the chemical structure of each amino acid side chain — as it is commonly represented in textbooks — with the physical models of each side chain supplied in the Amino Acid Starter Kit©. The poster features a dual color scheme. First, each atom of the side chain is color-coded according to atom type (red for oxygen, blue for nitrogen, gray for carbon and yellow for sulfur). Second, the base of each side chain is color-coded to reflect the overall chemical property of the side chain (yellow for hydrophobic side chains, red for acidic side chains, blue for basic side chains, white for hydrophilic but uncharged side chains and green for cysteines).

Amino Acid Starter Kit Poster© $24 (AASKP) Also see Amino Acid Starter Kit© (above) and Genetic Codon Posters© (page 8).

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Enzymes In Action Kit© Creating Catalytic Connections with Models Take your students beyond the simple lock-and-key concept of enzyme action with this dynamic, multifunctional kit. Color-coded foam pieces represent enzymes, a variety of substrates and inhibitors. Your students will use this kit to discover the specificity of substrate binding, how enzymes catalyze either catabolic or anabolic reactions and the effect of various inhibitors on enzyme action.

Each Enzymes In Action Kit© 1-group set contains 10 foam pieces (2 gray, 2 green, 2 orange, 1 red, 1 tan, 1 purple and 1 blue) and 1 sheet of stickers. Teacher notes and student handouts are available online. Multiply each item by 3, 6 or 12 for the 3-group, 6-group and 12-group sets. See Connections to A Framework for K-12 Science Education (pages 22 & 23). ! WARNING: CHOKING HAZARD 12-Group Set $106 (EAK-12) • 6-Group Set $58 (EAK-06) • 3-Group Set $33 (EAK-03) CAUTION: Science Education Product Please see bottom of page 2 for details.

Acetylcholinesterase Active Site Cube© Now your students can unfold an enzyme to see how the precisely positioned active site amino acids bind to specific substrates to catalyze a reaction. As your students open the active site cube they will see how the tightly-packed amino acid side chains bind the substrate (acetylcholine) and discover how 3 amino acids collaborate to cleave the neurotransmitter. Your students will explore how an insecticide targets the enzyme in mosquitoes and discover what happens when a mutation blocks the insecticide from binding to the enzyme. This has led to the emergence of Glu 367 insecticide-resistant mosquitoes. The substrate, insecticide and mutant His 480 Ser 238 amino acid side chain bind to the enzyme with magnets. The model is made of plaster by rapid prototyping and should be handled with care. It Acetylcholine Insecticide A mutant will break if dropped, held tightly or handled roughly. See Connections to (substrate) side chain A Framework for K-12 Science Education (pages 22 & 23).

! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS 5” Plaster Cube Model $950 (ACHASC-5) CAUTION: Science Education Product Please see bottom of page 2 for details. 3” Plaster Cube Model $475 (ACHASC-3) Not eligible for discounts 3DMD Genetic Codon Posters© The Genetic Codon Chart© and Genetic Codon Circle© can be used in conjunction with 3DMD’s popular Amino Acid Starter Kit©, β-Globin Folding Kit© and Insulin mRNA to Protein Kit© — which introduce your students to a standard color scheme: hydrophobic amino acids are yellow, polar amino acids are white, acidic amino acids are red, basic amino acids are blue and cysteines are green. By applying this same color scheme to the codon posters, your students can easily build a seamless connection between the triplet codon in mRNA and the chemical property of the amino acid it encodes.

Genetic Codon Chart© (24” x 30”) $24 each (GCCA) Genetic Codon Circle© (30” x 24”) $24 each (GCCB)

Best when used with the Amino Acid Starter Kit©, Amino Acid Starter Kit Poster© (Page 7), β-Globin Folding Kit© (page 6) and © The Genetic Codon Circle Insulin mRNA to Protein Kit© (page 9).

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Insulin mRNA to Protein Kit© A 3DMD BioInformatics and Mini Toober Folding Activity©

The Insulin mRNA to Protein Kit© helps your students understand that the specific sequence of ! WARNING: CHOKING HAZARD CAUTION: Science Education Product amino acids in a protein is encoded by the specific sequence of nucleotides in the corresponding gene. Please see bottom of page 2 for details. After using the BioInformatics Map to search for the nucleotide sequence that encodes the amino acid sequence of insulin, your students will fold a physical model of the 3-D structure of the insulin protein, using mini toobers (1 for the A-chain and 1 for the B-chain) and a folding map.

Each 1-group set includes student mRNA map, student folding map, 2 mini toobers, side chains, plastic clips, support posts, endcaps and an assortment of parts to mark and connect the chains. Teacher notes, 6-Group Set $260 (INSFK-06) student handouts and interactive Jmol visualization tools are available online. 3-Group Set $140 (INSFK-03) 1-Group Set $ 54 (INSFK-01) Multiply each item by 3 or 6 for the 3-group and 6-group sets (each set also includes 1 teacher mRNA map). See Connections to A Framework for K-12 Science Education (pages 22 & 23). It’s best if your students first use the Amino Acid Starter Kit© (page 7) before using the Insulin mRNA to Protein Kit©. Also see Insulin Mini Model and Insulin Poster© (below), ß-Globin Folding Kit© (page 6) and Genetic Codon Posters© (page 8).

Insulin Poster© By using the insulin protein as a starting point, teachers can weave together a broad range of biology topics including the flow of genetic information, biochemistry and protein structure, cellular organelles, anatomy, physiology and cell biology of glucose homeostasis, energy metabolism, the endocrine and digestive systems, recombinant DNA technologies and new approaches to monitor blood glucose levels and control diabetes.

Also see Insulin mRNA to Protein Kit© (above). Insulin Poster $21 (INSP)

Insulin Mini Model This alpha carbon backbone model of insulin, a 51-amino acid peptide hormone, features 2 chains (A is purple and B is orange) joined by two disulfide bonds. This model is useful in teaching basic principles of protein structure — including quaternary structure. Mini models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

4” Plaster Model $77 (IFKMM)

This mini model can be used as an accurate smaller scale template when using the Insulin mRNA to Protein Kit© (above).

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Hemoglobin Nylon Model If you could have only one model with which to teach proteins, this is it — a durable, hand-painted nylon model of hemoglobin. This quaternary complex includes 2 α-chains and 2 ß-chains. One of the ß-chains is magnet-docked so it can be removed for closer examination. The heme group and its oxygen on the removable ß-globin are also magnet-docked. The glutamic acid side chain at position 6 of the ß-globin chain can be exchanged for a valine side chain — representing the change in the ß-globin protein that leads to sickle cell anemia. 6.5” Hemoglobin $750 (NHGM) Not eligible for discounts

New ! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS CAUTION: Science Education Product Please see bottom of page 2 for details. Hemoglobin Poster© From exploring the question, "Why do we breathe?" to illustrating the structure of hemoglobin, the cause of sickle cell anemia and the physiology of oxygen transport, our colorful Hemoglobin Poster© will spark new inquiry among your students. Best used as a companion guide for 3DMD’s Hemoglobin Nylon Model (above), β-Globin Folding Kit© and β-Globin Mini Models (page 6), the poster can also stand alone to help facilitate meaningful discussions about hemoglobin. Hemoglobin Poster© (21" x 22") $21 (HGP)

DNA Mini Model This model immediately engages your students in thinking about the structure of DNA. You can guide a discussion of the nature of models — and the usefulness of multiple representations of any molecular structure. The DNA Mini Model represents the classic DNA double helix in 4 formats. The bottom section of the model shows a surface format emphasizing major and minor grooves. Moving up, all atoms are in a CPK colored spacefilled format. The next section shows the 4 nitrogenous bases in a CPK wireframe format. In the top section of the model, each of the 4 bases is colored with a solid color.

8” Plaster Model with Base $145 (DNA4FMM)

Adenosine Triphosphate Mini Model The Adenosine Triphosphate (ATP) Mini Model is based on the atomic coordinates of this important nucleotide. Both the second and third phosphates are joined 4” ATP Mini Model shown with 1” ATP model to the model with magnets — allowing students to easily move from adenosine built at the same scale monophosphate (AMP) to adenosine diphosphate (ADP) and ATP. This simple as the Molecules of Life model will change the way your students think about glycolysis and the citric acid Collection© on page 12. cycle. See Connections to A Framework for K-12 Science Education (pages 22 & 23). Phosphates do not detach from the 1” model. 4” Plaster Model $57 (ATPMM) Also see DNA Discovery Kit© (page 11).

! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS CAUTION: Science Education Product Please see bottom of page 2 for details.

Models are made of plaster by rapid prototyping and should be handled with care. They will break if dropped, held tightly or handled roughly. Nylon models are more resilient than plaster models, but will break if held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23). Page 10 3dmoleculardesigns.com

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Fall 2015 DNA Discovery Kit© Let your students discover the structure of DNA — just as Watson and Crick did. The DNA Discovery Kit© combines magnets with accurate 3-D nucleotides which make the kit self-instructive. As your students discover A-T and G-C base pairs, they will feel the hydrogen bonding. Teacher-developed and field-tested, the 12 Base Pair Set contains 6 A-T and 6 G-C base pairs, display stand and 2 mini toobers. Extensive activities, materials and background information are available online. The 2 Base Pair Set includes 1 A-T and 1 G-C base pair. See Connections to A Framework for K-12 Science Education (pages 22 & 23). Project Lead the Way© selected the DNA Discovery Kit© for its BioMedical Sciences™ Program.

12 Base Pairs (Classroom Set) $279 (DNA-12) 2 Base Pairs (A-T and G-C) $47 (DNA-02)

Also see Nucleosome, Ribosome and tRNA Mini Models (page 16), Tour of a Human Cell© (page 15) and Adenosine Triphosphate (ATP) Mini Model (page 10).

! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS CAUTION: Science Education Product Please see bottom of page 2 for details.

DNA Starter Kit© Engage your students with this interactive, foam model of double-stranded DNA and single- stranded RNA. The DNA Starter Kit© is a schematic model that transforms from the familiar ladder shape to the double helix with a twist. Your students can explore the structure of color- coded DNA bases showing purines and pyrimidines connected to a continuous sugar-phosphate backbone. Then they can explore the process of DNA replication and transcription. Using individual nucleotide monophosphates, they can synthesize a new strand of DNA — 1 base at a time — showing the semi-conservative replication of DNA. Finally, they can synthesize mRNA to show the process of transcription.

Each 1-group set includes 51 bases (12 red adenine, 12 yellow thymine, 12 blue cytosine, 12 green guanine, 3 white uracil), 4 continuous gray backbones, 24 gray sugar-phosphates and 12 lavender sugar-phosphates. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

2-Group Set $55 (DNASK-02) • 1-Group Set $30 (DNASK-01)

Triphosphate Expansion Pack You can turn the nucleotide monophosphates in the basic DNA Starter ! WARNING: CHOKING HAZARD Kit© into nucleotide triphosphates with the pieces in this expansion pack. CAUTION: Science Education Product The extra phosphates allow your students to model the action of the Please see bottom of page 2 for details. DNA polymerase as it cleaves the triphosphate and joins the nucleotide monophosphate to the growing DNA strand in replication. Triphosphates can also be used in transcription and to model ATP. Each pack includes 48 phosphate pieces and 48 connectors. Each pack $11 (DNASK-PEP)

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Molecules of Life Collection© The Molecules of Life Collection© features plaster models of the 4 major types of biomolecules — DNA, proteins, lipids and complex carbohydrates. Since the biomolecules exist and interact in an aqueous environment, water is also included. An associated model of a monomer building block goes with each biomolecule. A major teaching point is that large complex biomolecules are made of small, simple monomer units. All models are built to the same scale — 20 million times their real size.

The models sit on a 24” x 22” placemat that includes a description of each structure.

The entire set includes 17 models: DNA, adenosine monophosphate, aquaporin, asparagine, cell membrane, phospholipid, starch, glycogen, cellulose, glucose, ice structure, water molecule and placemat. Mini models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

© Molecules of Life Collection (17 plaster models and placemat) $550 (MLC) Molecules of Life Collection© is not eligible for discounts © Molecules of Life Monomer Set (2 models of each monomer) $60 (MLC-AM) Protein Ice Molecules of Life DNA (2 monomers and 1 polymer) $185 (MLC-D) Monomer Set Carbohydrate (2 monomers and 3 polymers) $106 (MLC-S) Glycogen Lipid (2 monomers and 1 polymer) $297 (MLC-L) Protein (2 monomers and 1 polymer) $206 (MLC-P) Ice (2 monomers and 1 polymer) $34 (MLC-I) Cellulose Molecules of Life Placemat© (without models) $21 (MLC-PM) Adenosine Triphosphate This model is built to the same scale but is not part of the $16 (MLC-ATP) Molecules of Life Collection©. It must be purchased separately. Starch

Lipid DNA Carbohydrate ! WARNING: CHOKING HAZARD Please see bottom of page 2 for details.

Hold the aquaporin and lipid models Adenosine Triphosphate next to each other as you discuss how proteins embed in The aquaporin cell membranes to model opens allow water and to show water other molecules or molecules rolling ions to pass in and over in their out of the cell. passage through the channel.

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New Flow of Genetic Information Kit© It’s the product that 3DMD customers have been asking for and a must-have for everyone who hasn’t seen its early versions! Our new Flow of Genetic Information Kit© will first allow your students to: • model DNA replication using color-coded, foam nucleotides and a placemat • model RNA transcription as they copy one strand of DNA into mRNA using an RNA polymerase • model translation/protein synthesis as they decode the mRNA into protein on the ribosome placemat Lessons and activities are available online. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

Flow of Genetic Information Kit© $114 (FGIK-01) Replacement DNA & RNA Nucleotide Set $23 (FGIK-R-NS) Side Chain Expansion Pack $27 (FGIK-SCEP)

Also see DNA Discovery Kit© and DNA Starter Kit© (page 11), DNA Mini Model (page 10), Molecules of Life© (page 12) and Tour of a Human Cell© (page 15).

! WARNING: CHOKING HAZARD CAUTION: Science Education Product Please see bottom of page 2 for details.

New Demo DNA Nucleotides© The sky is the limit to what you can teach using these new large-scale, color-coded foam nucleotides. Begin by teaching the complementary A-T and C-G base pairs and the antiparallel nature of double-stranded DNA. Move on to the flow of genetic information as you teach the basic processes of semiconservative DNA replication and mRNA transcription. You can then stretch your students by introducing PCR (polymerase chain reaction) and the Sanger DNA sequencing method — and much more. One set contains 80 nucleotides: 20 As, 20 Ts, 20 Cs and 20 Gs.

Demo DNA Nucleotides© $43 (DDNS-01) Also see DNA Discovery Kit© and DNA Starter Kit© (page 11), DNA Mini Model (page 10), Molecules of Life© (page 12) and Tour of a Human Cell© (page 15). ! WARNING: CHOKING HAZARD CAUTION: Science Education Product Please see bottom of page 2 for details.

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Alpha Helix & Beta Sheet Models The alpha helix and the beta sheet represent the 2 important protein structural elements of secondary protein structure. We feature 4 models for your students to explore — 2 alpha helix and 2 beta sheet models. One alpha helix and 1 beta sheet show the structure with side chains. The other models show the structure without side chains. Alpha Helix without Side Chains Beta Sheet Alpha Helix without Side Chains Both alpha sheet plaster models are derived from helix E of the β-globin (amino acids 58-74) protein, which consists predominantly of alpha helices. One model features 17 amino acids without side chains so your students can focus on the basic structure. The other features 17 amino acids with side chains.

Beta Sheet Both beta sheet plaster models are derived from amino acids 14-32 and 120-127 of green fluorescent protein. Two strands are parallel and 2 strands are anti-parallel. One model features 30 amino acids without side chains so Alpha Helix Beta Sheet your students can focus on the basic structure. The other features 30 amino with Side Chains with Side Chains acids with side chains.

The models are made of plaster in ball and stick format and follows the 4.5” Alpha Helix without Side Chains $75 (AH) standard CPK color scheme. They will break if dropped, held tightly or handled roughly. 4.75” Alpha Helix with Side Chains $128 (AHS) 6.5” Beta Sheet without Side Chains $130 (BS) Also see β-Globin Mini Models (page 6), Green Fluorescent Protein Mini Model (page 19) and Alpha Helix & Beta Sheet Construction Kit© (below). 7” Beta Sheet with Side Chains $225 (BSS)

Alpha Helix & Beta Sheet Construction Kit© This kit allows your students to build each of 2 important protein secondary structures — an alpha helix and a beta sheet. After joining together the magnetic backbone amino acid units to form the 2 structures, your students will actually feel the stabilizing effect of the hydrogen bonds as they are added to the backbone units. Then your students can add amino acid side chains, modeling specific alpha helices and beta sheets.

The models are made of plaster in ball and stick format and follows the standard CPK color scheme. They will break if dropped, held tightly or handled roughly.

Alpha Helix & Beta Sheet Construction Kit© $495 (AHBSCK)

Also see Alpha Helix & Beta Sheet Models (above), β-Globin Mini Models (page 6) and Green Fluorescent Protein Mini Model (page 19).

! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS CAUTION: Science Education Product Please see bottom of page 2 for details.

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David Goodsell Cellular Landscapes David Goodsell, PhD, scientist, author and artist of all things small, creates cellular landscapes that accurately illustrate the size, shape and distribution of proteins in their natural environment of the cell. These unique images connect the molecular world, inferred by X-ray crystallography and NMR spectroscopy, with the cellular world, observed by light and electron microscopy. These laminated prints of Goodsell’s stunning water color paintings illustrate biology in a dimension not seen in other instructional tools. Adjacent text identifies the structures and explains their functions. Whether teaching the flow of genetic information, the many jobs of proteins, energy metabolism or the immunology of a flu shot, these landscapes may be the missing piece in your current collection of instructional tools.

© Tour of a Human Cell Detail The Tour of a Human Cell Panorama© will take your students from the nucleus to the outer cell membrane. In the nucleus, DNA is wrapped around histones forming nucleosomes. RNA polymerase unwraps the DNA and makes mRNA which is delivered through nuclear pore complexes to ribosomes where antibody proteins are made and delivered into the endoplasmic reticulum. Vesicles carry the protein through the Golgi and kinesin motor proteins pull the antibodies to the cell membrane — a wonderful example of the immunology of your flu shot.

Tour of a Human Cell Grand Panorama© 23” x 11’ $88 (DGTHC-GP) • Tour of a Human Cell Panorama© 11” x 70” $40 (DGTHC-P)

Mitochondria, E. coli and Synapse Posters In the Mitochondria Poster© (top left) your students will see the large protein complexes of the electron transport chain which create the electrochemical gradient that powers ATP synthase to build ATP. ATP is then transported out of the mitochondrion by the adenine nucleotide translocator and diffuses through the channels in the VDAC protein in the outer membrane.

The E. coli Poster© (right) illustrates the inside of an E. coli cell — magnified 1 million times. The molecular complexity of this bacterial cell is emphasized in this image which features a large flagellum and the motor proteins that power its rotation and a variety of transmembrane proteins that function in transporting molecules into and out of the cell. Also shown are the ribosomes and associated proteins that support bacterial protein synthesis and the DNA, along with the DNA and RNA polymerases that function in replication and transcription. Mitochondria Poster© The Synapse Poster© (bottom left) illustrates the molecular interactions found at a neuromuscular synapse — where vesicles filled with the neurotransmitter, acetylcholine, are fusing with the membrane of the pre-synaptic axon. Following vesicle fusion, the acetylcholine diffuses across the synaptic space to bind to acetylcholine receptors found in the membrane of the muscle E. coli Poster© cell. Acetylcholinesterase is entangled in the synaptic space, where it breaks down excess neurotransmitter.

Mitochondria Poster© 23” x 30” $29 (DGMP) • E. coli Poster© 23” x 30” $29 (DGECP) • Synapse Poster© 23” x 30” $29 (DGSP)

Also see Tour of a Human Cell© (above), the DNA Discovery Kit© and DNA Starter Kit© (page 11) and the following mini models: Nucleosome, Ribosomes and tRNA (page 16), Antibody, Hemagglutinin and Influenza Virus Capsule (page 17). Synapse Poster©

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Nucleosome Mini Model The nucleosome is the most basic, repeating structural unit of chromosomes. Its central protein core has 8 histones (2 copies each of H2A, H2B, H3 and H4) and 145 base pairs of double-stranded DNA. The N-terminal end of each histone has many positively-charged amino acids that interact with the negatively- charged phosphate backbone of DNA. This model reveals that histones interact only with the minor groove of DNA. The major groove is then available for sequence-specific DNA binding proteins, such as Zif 268. 4” Plaster Model $199 (NCSMM) Also see Zinc Finger Mini Model (page 19), Tour of a Human Cell© (page 15), DNA Discovery Kit© and DNA Starter Kit© (page 11).

Large and Small Ribosome Mini Models Venkatraman Ramakrishnan, Thomas A. Steitz and Ada E. Yonath won the Nobel Prize in Chemistry in 2009 for studies of the structure and function of the ribosome. (nobelprize.org) Protein synthesis becomes understandable as your students see the 3 tRNAs of the small (30S) subunit and how they fit into the cavity of the large subunit (50S) to synthesize proteins. In the large subunit, they will see the single adenosine base (yellow) that catalyzes peptide bond formation during protein synthesis. The large subunit of a bacterial ribosome is a protein-RNA complex composed of 34 proteins and 2 rRNAs (23S and 5S). The rRNA folds into this specific 3-D structure, with the proteins serving as themortar between RNAs. The newly synthesized protein exits the ribosome through a visible channel that extends from the catalytic adenosine to the surface of the ribosome. The small subunit (30S) of the bacterial ribosome is a protein-rRNA complex composed of 21 proteins and a single RNA (16S). It folds into a specific 3-D structure and is stabilized by associated proteins. In this spacefilled model, two tRNAs (green) dock with their 3’ends close together— ready for peptide bond formation.

Pair $358 (R5030SMM) • 4” 50S Ribosome $214 (R50SMM) • 4” 30S Ribosome $184 (R30SMM) Also see Flow of Genetic Information Kit© (page 13) and Tour of a Human Cell© (page 15).

Transfer RNA Mini Models Transfer RNA (tRNA) is a short RNA molecule (76 nucleotides) that delivers amino acids to the ribosome, where they join to a growing chain during protein synthesis. Transfer RNAs fold into 3-D structures, stabilized by hydrogen bonding between complementary bases. In this model, the phosphate backbone of the tRNA is white, the 4 bases are red, the anticodon is blue and the 3’-end (where the amino acid is bound) is yellow.

3.5” Plaster Model $76 (TRNAMM)

Nylon tRNA RNA folds into complex 3D shapes — just like proteins. This nylon model of tRNA shows the details of this complex 3D structure — complete with the A-T and G-C base-pairs that stabilize the structure. The model allows students to explore the anti-codon of the tRNA, and the 3' end of tRNA where the charged amino acid is added. 3” Nylon Model $175 (NTRNAM) Also see DNA Discovery Kit© and DNA Starter Kit© (page 11), Flow of Genetic Information Kit© (page 13) and Tour of a Human Cell© (page 15).

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Antibody Mini Models Antibodies are composed of 12 immunoglobulin folds; 4 in each heavy chain (yellow in the model) and 2 in each light chain (red in the model). The antigen binding site of an antibody is composed of the ends of 2 immunoglobulin folds (1 yellow heavy chain and 1 red light chain) that are positioned at the tips of the Y-shaped antibody. With this model, you can introduce students to concepts of protein structure and function while teaching the immune system.

3.25” Plaster Antibody $70 (ANTMM) • 5” Nylon Antibody $275 (NANTM) Plaster Antibody Nylon Antibody

Hemagglutinin Mini Model The hemagglutinin protein (HA) of the influenza virus plays a critical role in the infection process. These models show the dramatically different shapes of the hemagglutinin HA2 protein at pH 7 and at pH 5. These models will allow you to tell an amazing molecular story — of how the virus takes advantage of the dramatic decrease in pH following the uptake of the virus by receptor-mediated endocytosis. Models magnet-dock onto the base and can be removed for closer examination. Color coding enables students to clearly see the conformational changes that the protein undergoes. This model can be used in conjunction with the Tour of the Human Cell© (page 15) that illustrates a ß-cell that has been stimulated to produce antibodies in response to the flu vaccine. 6.5” Tall Plaster Mini Model $86 (HAMM)

Influenza Virus Capsules Influenza is an RNA virus with a roughly spherical lipid envelope, which is colored yellow on our schematic model. The outside of the virus capsule is covered with 3 specific proteins: hemagglutinin (HA, purple), neuraminidase (NA, pink) and the M2 channel (blue). These 3 proteins are 4" Influenza Virus Capsule involved in virus docking, endocytosis and fusion of the viral membrane to the host cell, the release of newly budded virus from infected cells, and acidification of the virus core and release of the segmented viral RNA. The specific sub-types and combinations of the hemagglutinin (H) and neuraminidase (N) on the surface of the virus capsule categorize the strain of the virus. The viral RNA is represented by 8 segments of RNA — some colored red and some colored yellow — to represent a re-assorted virus emerging from a host cell simultaneously infected with a swine flu virus and an avian flu virus (H1N1 swine flu).

6" Influenza Virus Capsule 6'' Plaster Model $600 (IVCM6) • 4” Plaster Mini Model $450 (IVCM4) 6" Plaster Model is not eligible for discounts

Also see Tour of a Human Cell© (page 15).

Use Nucleosome, Ribosomes, tRNA, Antibody, Hemagglutinin and Influenza Virus Capsule with the Tour of a Human Cell© (page 15) to tell the story of a flu shot in action. Models are made of plaster by rapid prototyping and should be handled with care. They will break if dropped, held tightly or handled roughly. Nylon models are more resilient than plaster models, but will break if held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

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Modeling as a Practice of Science The Next Generation Science Education Standards emphasize the important role of modeling — both as an authentic practice of science and as an important learning tool for students. 3D Molecular Designs offers 2 instructional tools,The Data Dilemma© and the Mystery Tube©, to engage students in an active modeling experience, while introducing them to the practice of science.

The Data Dilemma© While using The Data Dilemma© your students will experience the dilemma scientists face when new data indicates the mental model of the object they are researching needs to be modified.As each new data set is introduced and your students form a series of new models — using foam tangram pieces — your students will learn that the practice of science is an ongoing process, not a set of facts published in a textbook or online. How many possible models can your students find? Teacher notes are available online. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

! WARNING: CHOKING HAZARD 12-Puzzle Set $24 (DD-12) CAUTION: Science Education Product Please see bottom of page 2 for details.

Mystery Tube© A Black Box Activity The Mystery Tube© introduces your students to the practice of science. Research scientists frequently face the challenge of examining an object or organism without taking it apart. As your students first pull the cord on one end and the other end pulls into the tube, they may think the solution is easy. But wait, as they continue their investigation, they will be challenged to describe a model for the inner workings of the Mystery Tube© and provide supporting evidence to defend their hypothesis. Teacher notes and student handouts are available online. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

! WARNING: CHOKING HAZARD 12-Tube Set $104 (MTAB-12) • 6-Tube Set $56 (MTAB-06) • 2-Tube Set $21 (MTAB-02) CAUTION: Science Education Product Please see bottom of page 2 for details.

Modeling Mini Toobers Versatile mini toobers provide hands-on learning experiences in many science disciplines. Biology and chemistry students can model DNA or create protein structures while following the principles of chemistry. Physics students can explore sound and other waves. The flexible foam mini toobers have a soft wire core and are 4’ long. One red and one blue end cap is included with each mini toober. Use end caps to designate N terminus and C terminus in protein-folding or 3’ and 5’ ends in DNA model. Push Pins Are Not Included. 3DMD’s protein folding activity is available online. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

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Amino Acid Building Block Models These Amino Acid Building Block Models from Molymod enable your students to explore the basic structure of amino acids — the building blocks of proteins. The kit contains all of the atoms and bonds needed to construct 2 models of a generic amino acid. Side chains are represented by the green spheres. The 2 amino acids can be joined by a peptide bond to make a dipeptide — splitting out a water molecule. Activities for using the models are available online.

Amino Acid Building Block Models $30 (AABB) ! WARNING: CHOKING HAZARD Also see Amino Acid Starter Kit© (page 7). CAUTION: Science Education Product Please see bottom of page 2 for details.

Green Fluorescent Protein Mini Model Green Fluorescent Protein (GFP) is responsible for the green bioluminescence of many marine organisms, including Pacific Northwest jellyfish. Its structure consists of an 11-stranded beta barrel surrounding a central alpha helix containing the fluorophore that emits light. The backbone is color-coded for students to follow the folding of the protein from its amino- to its carboxy-terminus. It is an excellent tool when teaching protein structure and biotechnology. Mini models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

Zinc Finger Mini Model A zinc finger is a short (~30 amino acid)protein motif that is often found in proteins that bind to DNA. Zif268 is a DNA binding protein that contains 3 consecutive zinc fingers. Proteins with zinc fingers are one of the largest families of proteins found in the human genome. Each zinc finger consists of a two-stranded beta sheet and a short alpha helix. Its structure is stabilized by 2 cysteines and 2 histidines that bind to a single zinc atom. Mini models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

Water Tattoos With these fun Water Tattoos you can simultaneously reward your students and reinforce concepts related to the three states of water. Each set contains 50 Water Vapor Tattoos, 50 Liquid Water Tattoos and 50 Frozen Water Tattoos.

States of Water Tattoos Set $29 (SWTS)

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Science Olympiad Protein Modeling Event Kits This year's challenge focuses on the sepiapterin reductase enzyme, which is needed to make neurotransmitters. A mutation in the gene that encodes this protein was identified by whole genome sequencing in 2010, leading to a molecular diagnosis and successful treatment of California twins with gene variants causing them to have life-threatening low levels of three neurotransmitters. A model of a portion of the sepiapterin reductase enzyme must be created and submitted prior to each competitive event. Visit cbm.msoe.edu/scienceOlympiad for resources to help hone your protein structure and modeling skills.

See optional supporting materials on the next page.

The materials in the Pre-Build Kit can be reused for each competition. The model should represent amino acids 93-261 of chain A of the sepiapterin reductase protein, based on PDB file 1sep.pdb.

The Practice Kit simulates the competition environment and is modeled after the 2014-2015 State On-Site Competition. It should represent amino acids 289-356 of chain A of the protein dHax3, based on the PDB file 3v6t.pdb. The 2015-2016 Practice Judging Model is also available for purchase.

The best preparation for understanding protein structure and function is our Amino Acid Starter Kit©. Purchase our Pre-Build Kit and Amino Acid Starter Kit Bundle for $78.20 and save 15%! (Regularly priced $92.)

Tournament directors and event supervisors, please visit 3dmoleculardesigns.com/ Science-Olympiad-Protein-Modeling-Kits.htm for information about ordering Invitational On-Site Kits and Invitational Test Materials (plaster models and exam materials). Sign up at cbm.msoe.edu/scienceOlympiad to receive Regional, State and National On-Site Kits, Exams and Judging Materials free of charge. ! WARNING: CHOKING HAZARD ! WARNING: SMALL MAGNETS CAUTION: Science Education Product Please see bottom of page 2 for details. Pre-Build Kit $31 (SOPB16) Practice Kit $29 (SOPK16) Practice Judging Model $47 (SOPJM) Pre-Build Kit and Amino Acid Starter Kit© Bundle $78.20 (SOAA16)

Also see Neurotransmitters Module: The Beery Twins' Story (Page 21).

Save 15% on the Pre-Build Kit (SOPB16) and Practice Kit (SOPK16) when you order by January 15, 2016!

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Fall 2015 Neurotransmitters Module: The Beery Twins’ Story A Project-Based Learning Activity

Captivate your students and cover a wide-range of science topics with the true story of California twins Noah and Alexis Beery, who have gene variants that cause them to have life-threatening low levels of three neurotransmitters. Whole genome sequencing in 2010 identified a mutation in the gene that encodes the sepiapterin reductase enzyme, leading to a molecular diagnosis and successful treatment.

This gene map presents the nucleotide sequence of the messenger RNA encoding sepiapterin reductase – the enzyme that was shown to be defective in Noah and Alexis Beery. The map documents the molecular consequence of two different mutations in this gene that were responsible for the neurotransmitter deficiencies experienced by the Beery twins. The Beery family’s story is featured in the 2016 Science Olympiad Protein Modeling event. Teacher notes and student handouts are available online.

1 Student and 1 Teacher Human SPR mRNA Gene Map $33 (SPRGM-01S-01T) 3 Student and 1 Teacher Human SPR mRNA Gene Map $59 (SPRGM-03S-01T) 6 Student and 1 Teacher Human SPR mRNA Gene Map $97 (SPRGM-06S-01T)

Dopamine and Serotonin Biosynthesis Models

These models show how two amino acids (tyrosine and tryptophan) are converted into two neurotransmitters (dopamine and serotonin) by two consecutive enzyme-catalyzed reactions. Magnet-docked hydroxyl groups, carboxylate groups and hydrogens allow each model to be quickly converted from amino acid to neurotransmitter in two easy steps. The biosynthesis of dopamine and serotonin is addressed in the 2016 Science Olympiad Protein Modeling Event. Placemats and supporting materials shown below are Dopamine Biosynthesis Model available online. Serotonin Biosynthesis Model

3” Dopamine Biosynthesis Model $37 (DBMM) • 3” Serotonin Biosynthesis Model $39 (SBMM)

The gene map and biosynthesis models may be used separately or together to meet the needs of your classroom. Also see Science Olympiad Protein Modeling Event Kits on the previous page (page 20).

Models are made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. See Connections to A Framework for K-12 Science Education (pages 22 & 23).

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Next Generation Science Standards – Developing and Using Models The Next Generation Science Standards emphasize the important role of models (and modeling) as an authentic practice of scientists and engineers. As outlined in the NRC’s Framework for the Next Generation Standards1: Scientists construct mental and conceptual models of phenomena. Modeling can begin in the earliest grades, with students’ models Mental models are internal, personal, idiosyncratic, incomplete, progressing from concrete “pictures” and/or physical scale models unstable, and essentially functional. They serve the purpose of (e.g., a toy car) to more abstract representations of relevant being a tool for thinking with, making predictions, and making relationships in later grades, such as a diagram representing forces sense of experience. Conceptual models2 are, in contrast, explicit on a particular object in a system. Students should be asked to use representations that are in some ways analogous to the phenomena diagrams, maps, and other abstract models as tools that enable them they represent. to elaborate on their own ideas or findings and present them to others. Young students should be encouraged to devise pictorial and simple Conceptual models are in some senses the external articulation of graphical representations of the findings of their investigations and to the mental model that scientists hold and are strongly interrelated use these models in developing their explanations of what occurred. with mental models. Building an understanding of models and their role in science helps students to construct and revise mental models More sophisticated types of models should increasingly be used of phenomena. Better mental models, in turn, lead to a deeper across the grades, both in instruction and curriculum materials, understanding of science and enhanced scientific reasoning. as students progress through their science education. Curricula will need to stress the role of models explicitly and provide Scientists use models to represent their current understanding of a students with modeling tools so that students come to value this system (or parts of a system) under study, to aid in the development core practice and develop a level of facility in constructing and of questions and explanations, and to communicate ideas to others. applying appropriate models. Connections to A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas Dimension 1: Scientific and Engineering Practices Dimension 2: Cross Cutting Concepts 1. Asking questions (for science) and defining problems (for engineering) 1. Patterns 2. Developing and using models 2. Cause and effect: mechanism and explanation 3. Planning and carrying out investigations 3. Scale, proportion, and quantity 4. Analyzing and interpreting data 4. Systems and system models 5. Using mathematics and computational thinking 5. Energy and matter: flows, cycles, and conservation 6. Constructing explanations (for science) and designing solutions 6. Structure and function (for engineering) 7. Stability and change 7. Engaging in argument from evidence 8. Obtaining, evaluating, and communicating information 3D Molecular Designs Products Amino Acid Starter Kit©: 1, 2, 4, 5, 6 3D Molecular Designs Products ß-Globin Folding Kit©: 2, 3, 6, 7 Amino Acid Starter Kit©: 2, 5 Demo DNA Nucleotides©: 1, 2, 6, 7 ß-Globin Folding Kit©: 2, 4, 5 DNA Discovery Kit©: 1, 2, 6, 7 Demo DNA Nucleotides©: 1, 2 DNA Starter Kit©: 1, 2, 6, 7 DNA Discovery Kit©: 1, 2 Enzymes in Action Kit©: 1, 2, 4, 6, 7 DNA Starter Kit©: 1, 2 Flow of Genetic Information Kit©: 1, 2, 3, 6, 7 Enzymes in Action Kit©: 1, 2, 6 Human Sepiapterin mRNA Gene Map©: 1, 2, 4, 6, 7 Flow of Genetic Information Kit©: 1, 2, 6 Insulin mRNA to Protein Kit©: 1, 2, 3, 5, 6, 7 Human Sepiapterin mRNA Gene Map©: 1, 2, 4, 6 Map of the Human ß-Globin Gene©: 1, 2, 6, 7 Insulin mRNA to Protein Kit©: 2, 4 Mystery Tube©: 2, 3, 4, 6 Map of the Human ß-Globin Gene©: 2, 4 NaCl©: 1, 2, 3, 6, 7 Mystery Tube©: 1, 2, 3, 4, 5, 6, 7, 8 Phospholipid & Membrane Transport Kit©: 1, 2, 3, 6, 7 NaCl©: 2, 5, 6 7, 8 Posters, Mini Models, Molecules of Life Collection© Phospholipid & Membrane Transport Kit©: 1, 2, 6, 7, 8 Acetylcholinesterase Active Site Cube: 1, 2, 3 Posters, Mini Models, Molecules of Life Collection© Science Olympiad Protein Modeling Event Kits: 1, 2, 3, 6, 7 Acetylcholinesterase Active Site Cube: 2 The Data Dilemma©: 1 Science Olympiad Protein Modeling Event Kits: 1, 2, 4, 5, 6, 7, 8 Water Kit©: 1, 2, 3, 4, 5, 6, 7 The Data Dilemma©: 1, 2, 4, 5, 8 Water Kit©: 1, 2, 5 1 National Research Council. (2012) A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas. nap.edu/catalog.php?record_id=13165 2 As used here, “conceptual models” include physical models of proteins, as offered by 3D Molecular Designs. Page 22 3dmoleculardesigns.com

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WinterFall 2015 2015 Dimension 3: Disciplinary Core Ideas: Physical Sciences PS1: Matter and Its Interactions LS2: Ecosystems: Interactions, Energy, and Dynamics PS1.A: Structure and Properties of Matter LS2.A: Interdependent Relationships in Ecosystems PS1.B: Chemical Reactions LS2.B: Cycles of Matter and Energy Transfer in Ecosystems PS1.C: Nuclear Processes LS2.C: Ecosystem Dynamics, Functioning, and Resilience

PS2: Motion and Stability: Forces and Interactions LS3: Heredity: Inheritance and Variation of Traits PS2.A: Forces and Motion LS3.A: Inheritance of Traits PS2.B: Types of Interactions LS3.B: Variation of Traits PS2.C: Stability and Instability in Physical Systems LS4: Biological Evolution: Unity and Diversity PS3: Energy LS4.A: Evidence of Common Ancestry and Diversity PS3.A: Definitions of Energy LS4.B: Natural Selection PS3.B: Conservation of Energy and Energy Transfer LS4.C: Adaptation PS3.C: Relationship Between Energy and Forces LS4.D: Biodiversity and Humans PS3.D: Energy in Chemical Processes and Everyday Life 3D Molecular Designs Products 3D Molecular Designs Products Amino Acid Starter Kit©: LS1, LS3, LS4 Amino Acid Starter Kit©: PS1, PS2, PS3 ß-Globin Folding Kit©: LS1, LS3, LS4 ß-Globin Folding Kit©: PS1 Demo DNA Nucleotides©:LS1, LS3, LS4 Demo DNA Nucleotides©:PS1, PS2 DNA Discovery Kit©: LS1, LS3, LS4 DNA Discovery Kit©: PS1, PS2 DNA Starter Kit©: LS1, LS3, LS4 DNA Starter Kit©: PS1, PS2 Enzymes in Action Kit©: LS1, LS2 Enzymes in Action Kit©: PS1 Flow of Genetic Information Kit©: LS1, LS3, LS4 Flow of Genetic Information Kit©: PS1 Human Sepiapterin mRNA Gene Map©: LS1, LS3 Human Sepiapterin mRNA Gene Map©: PS1 Insulin mRNA to Protein Kit©: LS1, LS3 Insulin mRNA to Protein Kit©: PS1, PS2 Map of the Human ß-Globin Gene©:LS1, LS3, LS4 Mystery Tube©: PS2 Phospholipid & Membrane Transport Kit©: LS1 Phospholipid & Membrane Transport Kit©: PS1 Posters, Mini Models, Molecules of Life Collection© Posters, Mini Models, Molecules of Life Collection© Acetylcholinesterase Active Site Cube: LS1 Acetylcholinesterase Active Site Cube: PS1 Science Olympiad Protein Modeling Event Kits: LS1 Science Olympiad Protein Modeling Event Kits: PS1, PS2 Water Kit©: LS1, LS2 Water Kit©: PS1, PS2 Engineering, Technology and Applications of Science Earth and Space Sciences ETS1: Engineering Design ESS2: Earth’s Systems ETS1.A: Defining and Delimiting an Engineering Problem ESS2.A: Earth Materials and Systems ETS1.B: Developing Possible Solutions ESS2.C: The Roles of Water in Earth’s Surface Processes ETS1.C: Optimizing the Design Solution ESS2.D: Weather and Climate ETS2: Links Among Engineering, Technology, Science, and ESS2.E: Biogeology Society ESS3: Earth and Human Activity ETS2.A: Interdependence of Science, Engineering, and Technology ESS3.A: Natural Resources ETS2.B: Influence of Engineering, Technology, and Science on ESS3.B: Natural Hazards Society and the Natural World ESS3.C: Human Impacts on Earth Systems 3D Molecular Designs Products ESS3.D: Global Climate Change Amino Acid Starter Kit©: ETS2 Demo DNA Nucleotides©:ETS1, ETS2 3D Molecular Designs Products DNA Discovery Kit©: ETS1, ETS2 © NaCl : EES2 DNA Starter Kit©: ETS1, ETS2 © Water Kit : EES2, EES3 Flow of Genetic Information Kit©: ETS1 Human Sepiapterin mRNA Gene Map©: ETS1, ETS2 Life Sciences Insulin mRNA to Protein©: ETS2 LS1: From Molecules to Organisms: Structures and Processes Mystery Tube©: ETS1 LS1.A: Structure and Function Phospholipid & Membrane Transport Kit©: ETS1 LS1.B: Growth and Development of Organisms The Data Dilemma©: ETS1 LS1.C: Organization for Matter and Energy Flow in Organisms Science Olympiad Protein Modeling Event Kits: ETS1, ETS2 LS1.D: Information Processing

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Product Index by Category Water and Membrane Water Kit© and NaCl Lattice© ...... 3 Science Olympiad Protein Modeling Event Pre-Build Kit and Practice Kit ...... 20 Channel Mini Models: Sodium Channel, Aquaporin Channel, © Potassium Channel and Potassium Human Sepiapterin Reductase mRNA Gene Map and Channel with Scorpion Toxin ...... 4 Dopamine and Serotonin Biosynthesis Models ...... 21 Phospholipid & Membrane Transport Kit© and Phospholipid Modeling Set© ...... 5 Project-Based Learning Activities © Neurotransmitters Module: Molecules of Life Collection ...... 12 © Water Tattoos..……………………………………………………... 19 The Beery Twins’ Story Human Sepiapterin Reductase mRNA Gene Map© and DNA Dopamine and Serotonin Biosynthesis Models ...... 21 DNA Discovery Kit© and DNA Starter Kit© ...... 11 Flow of Genetic Information Kit© and Kits © Water Kit© ...... 3 Demo DNA Nucleotides ...... 13 © DNA and Adenosine Triphosphate Mini Models ...... 10 Phospholipid & Membrane Transport Kit ...... 5 © ß-Globin Folding Kit© ...... 6 Molecules of Life Collection ...... 12 © Ribosomes and Transfer RNA Mini Models ...... 16 Amino Acid Starter Kit ...... 7 Enzymes in Action Kit© ...... 8 © Amino Acids and Protein Structure Insulin mRNA to Protein Kit ...... 9 ß-Globin Folding Kit©, Prefolded Model and DNA Discovery Kit© and DNA Starter Kit ...... 11 Flow of Genetic Information Kit© ...... 13 ß-Globin Mini Models ...... 6 © Amino Acid Starter Kit© and Amino Acid Alpha Helix & Beta Sheet Construction Kit ...... 14 Starter Kit Poster© ...... 7 Science Olympiad ...... 20 Genetic Codon Posters© ...... 8 Insulin mRNA to Protein Kit©, Insulin Poster© and Plaster and Nylon Models and Mini Models Insulin Mini Model ...... 9 Sodium Channel, Aquaporin Channel, Potassium Channel and Modeling Mini Toobers ...... 18 Potassium Channel with Scorpion Toxin ...... 4 Molecules of Life Collection© ...... 12 ß-Globin ...... 6 Alpha Helix & Beta Sheet Construction Kit© and Acetylcholinesterase Active Site Cubes ...... 8 Alpha Helix & Beta Sheet Models ...... 14 Insulin ...... 9 Amino Acid Building Block Models and Hemoglobin, DNA and Adenosine Triphosphate ...... 10 Zinc Finger Mini Model ...... 19 Alpha Helix & Beta Sheet ...... 14 Nucleosome, Ribosomes and Transfer RNA ...... 16 Antibody, Hemagglutinin and Enzymes Amino Acid Starter Kit© ...... 7 Influenza Virus Capsules ...... 17 Enzymes in Action Kit© and Acetylcholinesterase Green Fluorescent Protein and Zinc Finger ...... 19 Active Site Cubes© ...... 8 Dopamine and Serotonin Biosynthesis Models ...... 21

Posters ß-Globin © ß-Globin Folding Kit©, ß-Globin Mini Models and Amino Acid Starter Kit Poster ...... 7 © Genetic Codon Posters© ...... 8 Map of the Human ß-Globin Gene ...... 6 © Hemoglobin Nylon Model and Poster© ...... 10 Insulin Poster ...... 9 Hemoglobin Poster© ...... 10 David Goodsell Cellular Landscapes: Practice of Science © © The Data Dilemma© and Mystery Tube© ...... 18 Tour of a Human Cell , Mitochondria Poster , E. coli Poster© and Synapse Poster© ...... 15

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