Pancreatic Polypeptide Pancreatic • • • •

Alphabetical Test Section 4789X Extraction, radioimmunoassay (RIA) radioimmunoassay Extraction, 50 pg/mL sensitivity: Analytical no cross- specificity: Analytical or insulin with glucagon reaction Clinical Background is a 32- (PP) polypeptide Pancreatic is produced that peptide acid amino cells of the endocrine by the primarily extracts present in it is also pancreas; The physiological mucosa. of gastric clearly defined. of PP is not role by hypo- is influenced Secretion and injection, pentagastrin glycemia, Plasma meals. of protein ingestion with change normally concentrations time and ingestion, type of food age, collection. of blood in the are used PP concentrations tumors. PP-producing of management observed have been plasma levels High with pancreatic patients in some and (VIPomas tumors endocrine endocrine multiple insulinomas), (MEN 1), type 1 syndrome neoplasia and medullary carcinoma, thyroid syndrome. Zollinger-Ellison level MEN 1, a PP with In patients the age-matched than 3 times greater an islet suggestive of mean is normal cell tumor. Method • • • Specimen Requirements plasma EDTA refrigerated 2 mL minimum 0.6 mL is preferred. fasting Overnight 135 163 180 276 644 519 361 297 480 1990;30:65-70, 1990;30:65-70, 1989;21:38-42, and 1980;69:211-214. Reprod Nutr Dev. Nutr Dev. Reprod Zollinger-Ellison syndrome Zollinger-Ellison Medullary carcinoma thyroid Insulinoma VIPoma • • • • Preterm infants*Preterm < Term infants*Term < Term infants-6 d* infants-6 Term y*1 mo-2 3-9 y y10-13 y14-17 < < < < < 30-39 y30-39 y40-49 y50-62 y>62 blood Cord 70-400 established Not 70-430 100-780 Predict recurrence of pancreatic of pancreatic recurrence Predict tumors Monitor pancreatic carcinoma carcinoma pancreatic Monitor therapy Assist in early diagnosis of pancreatic diagnosis of pancreatic Assist in early tumors Assess pancreatic tumor burden tumor pancreatic Assess 18-29 y18-29 < Children *Data from *Data from Adults pg/mL Materia Medica Polona. Acta Paediatr Scand. Interpretive Information Interpretive Reference Range Reference Clinical Use Pancreatic Polypeptide Pancreatic • • • •