RAD51L3 Monoclonal Antibody, Clone 5B3/6

RAD51L3 monoclonal antibody, member of the RAD51 protein family. RAD51 family clone 5B3/6 members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to Catalog Number: MAB2395 be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other Regulatory Status: For research use only (RUO) members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed Product Description: Mouse monoclonal antibody with this protein has been shown to catalyze raised against recombinant RAD51L3. homologous pairing between single- and double-stranded DNA, and is thought to play a role in the Clone Name: 5B3/6 early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have Immunogen: Recombinant His fusion protein been described, but the biological validity of some of corresponding to human RAD51L3. them has not been determined. [provided by RefSeq]

Host: Mouse References: 1. Dysfunctional homologous recombination mediates Reactivity: Human genomic instability and progression in myeloma. Applications: ICC, IF, WB-Ce Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, (See our web site product page for detailed applications Li C, Munshi NC. Blood. 2009 Mar 5;113(10):2290-7. information) Epub 2008 Dec 2. 2. Repression of mutagenesis by Rad51D-mediated Protocols: See our web site at homologous recombination. Hinz JM, Tebbs RS, Wilson http://www.abnova.com/support/protocols.asp or product PF, Nham PB, Salazar EP, Nagasawa H, Urbin SS, page for detailed protocols Bedford JS, Thompson LH. Nucleic Acids Res. 2006 Mar 6;34(5):1358-68. Print 2006. Specificity: This antibody is specific to Rad51D. 3. Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic Form: Liquid instability and prostate cancer progression. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow Isotype: IgG1 RG. Cancer Res. 2004 Dec 1;64(23):8526-33.

Recommend Usage: Immunocytochemistry (1:100) Immunofluorescence (1:500) Western Blot (1:1000) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS

Storage Instruction: Store at 4°C. Do not freeze.

Entrez GeneID: 5892

Gene Symbol: RAD51L3

Gene Alias: HsTRAD, R51H3, RAD51D, Trad

Gene Summary: The protein encoded by this gene is a

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