FMP Publications 2014 – 2020

 2019  2018  2017  2016  2015  2014

2020

§, # equal contribution; * corresponding author(s); bold: FMP members

Alsalim, R., P. Lindemann, M. P. Lopez-Alberca, S. Miksche, W. Czechtizky, N. Halland*, M. Nazare*, A Palladium- Catalyzed Domino Reaction To Access 3-Amino-2H-indazoles from Hydrazines and 2-Halobenzonitriles. Org Lett online ahead of print (2020). https://doi.org/10.1021/acs.orglett.0c02766 Barone, M., M. Müller, S. Chiha, J. Ren, D. Albat, A. Soicke, S. Dohmen, M. Klein, J. Bruns, M. van Dinther, R. Opitz, P. Lindemann, M. Beerbaum, K. Motzny, Y. Roske, P. Schmieder, R. Volkmer, M. Nazare, U. Heinemann, H. Oschkinat, P. Ten Dijke*, H. G. Schmalz*, R. Kühne*, Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells. Proc Natl Acad Sci USA online ahead of print (2020). https://doi.org/10.1073/pnas.2007213117 Baumann, A. L., S. Schwagerus, K. Broi, K. Kemnitz-Hassanin, C. E. Stieger, N. Trieloff, P. Schmieder, C. P. R. Hackenberger*, Chemically Induced Vinylphosphonothiolate Electrophiles for Thiol-Thiol Bioconjugations. J Am Chem Soc 142, 9544-9552 (2020). https://doi.org/10.1021/jacs.0c03426 Bertovic, I., R. Kurelic, I. Milosevic, M. Bender, M. Krauss, V. Haucke, A. Jurak Begonja*, Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes. J Thromb Haemost 18, 1756-1772 (2020). https://doi.org/10.1111/jth.14764 Braun*, B. C., N. Halaski, J. Painer, E. Krause, K. Jewgenow, The antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes. Sci Rep 10, 3681 (2020). https://doi.org/10.1038/s41598- 020-60634-x Brennecke, B., Q. Wang, Q. Zhang, H. Y. Hu*, M. Nazaré*, An Activatable Lanthanide Luminescent Probe for Time- Gated Detection of Nitroreductase in Live Bacteria. Angew Chem Int Ed 59, 8512-8516 (2020). https://doi.org/10.1002/anie.202002391 Chilczuk, T., R. Monson, P. Schmieder, V. Christov, H. Enke, G. Salmond, T. H. J. Niedermeyer*, Ambigols from the Cyanobacterium Fischerella ambigua Increase Prodigiosin Production in Serratia spp. ACS Chem Biol 15, 2929- 2936 (2020). https://doi.org/10.1021/acschembio.0c00554 Chin, A. C., Z. Gao, A. M. Riley, D. Furkert, C. Wittwer, A. Dutta, T. Rojas, E. R. Semenza, R. A. Felder, J. L. Pluznick, H. J. Jessen, D. Fiedler, B. V. L. Potter, S. H. Snyder*, C. Fu*, The inositol pyrophosphate 5-InsP7 drives sodium- potassium pump degradation by relieving an autoinhibitory domain of PI3K p85alpha. Sci Adv 6, eabb8542 (2020). https://doi.org/10.1126/sciadv.abb8542 Chow*, W. Y., B. P. Norman, N. B. Roberts, L. R. Ranganath, C. Teutloff, R. Bittl, M. J. Duer, J. A. Gallagher*, H. Oschkinat*, Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. Angew Chem Int Ed 59, 11937-11942 (2020). https://doi.org/10.1002/anie.202000618 Clochard, J., G. Jerz, P. Schmieder, H. Mitdank, M. Tröger, S. c. Sama, A. Weng, A new acetylated triterpene saponin from Agrostemma githago L. modulates gene delivery efficiently and shows a high cellular tolerance. Int J Pharmaceut 589, 119822 (2020). https://doi.org/10.1016/j.ijpharm.2020.119822 D'Andrea, E. D., Y. Roske, G. A. P. de Oliveira, N. Cremer, A. Diehl, P. Schmieder, U. Heinemann, H. Oschkinat, J. R. Pires, Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi. J Struct Biol 211, 107536 (2020). https://doi.org/10.1016/j.jsb.2020.107536 Dema, A., D. Faust, K. Lazarow, M. Wippich, M. Neuenschwander, K. Zühlke, A. Geelhaar, T. Pallien, E. Hallscheidt, J. Eichhorst, B. Wiesner, H. Cernecka, O. Popp, P. Mertins, G. Dittmar, J. P. von Kries, E. Klussmann, Cyclin- Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP. Cells 9, E673 (2020). https://doi.org/10.3390/cells9030673 Desmarini, D., S. Lev, D. Furkert, B. Crossett, A. Saiardi, K. Kaufman-Francis, C. Li, T. C. Sorrell, L. Wilkinson-White, J. Matthews, D. Fiedler, J. T. Djordjevic*, IP7-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery. mBio 11 (2020). https://doi.org/10.1128/mBio.01920-20 Dohmen, S., M. Reiher, D. Albat, S. Akyol, M. Barone, J. M. Neudorfl, R. Kühne, H. G. Schmalz*, Pd-Catalyzed Asymmetric N-Allylation of Amino Acid Esters with Exceptional Levels of Catalyst Control: Stereo-Divergent Synthesis of ProM-15 and Related Bicyclic Dipeptide Mimetics. Chemistry 26, 3049-3053 (2020). https://doi.org/10.1002/chem.202000307 Ercu, M., L. Marko, C. Schächterle, D. Tsvetkov, Y. Cui, S. Maghsodi, T. U. P. Bartolomaeus, P. G. Maass, K. Zühlke, N. Gregersen, N. Hübner, R. Hodge, A. Mühl, B. Pohl, R. M. Illas, A. Geelhaar, S. Walter, H. Napieczynska, S. Schelenz, M. Taube, A. Heuser, Y. M. Anistan, F. Qadri, M. Todiras, R. Plehm, E. Popova, R. Langanki, J. Eichhorst, M. Lehmann, B. Wiesner, M. Russwurm, S. K. Forslund, I. Kamer, D. N. Müller, M. Gollasch, A. Aydin, S. Bähring, M. Bader, F. C. Luft, E. Klussmann, Phosphodiesterase 3A and Arterial Hypertension. Circulation 142, 133-149 (2020). https://doi.org/10.1161/CIRCULATIONAHA.119.043061 Ernst, S., F. Ecker, M. S. Kaspers, P. Ochtrop, C. Hedberg, M. Groll, A. c. Itzen, Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination. Sci Adv 6, eaaz8041 (2020). https://doi.org/10.1126/sciadv.aaz8041 Fang, Z., S. Chen, Y. Manchanda, P. Bitsi, P. Pickford, A. David, M. M. Shchepinova, I. Corrêa Jr, D. J. Hodson, J. Broichhagen, E. W. Tate, F. Reimann, V. Salem, G. A. Rutter, T. Tan, S. R. Bloom, A. Tomas, B. J. Jones, Ligand- specific factors influencing GLP-1R post-endocytic trafficking and degradation. Int J Mol Sci, accepted (2020). Fang, Z., S. Chen, P. Pickford, J. Broichhagen, D. J. Hodson, I. R. Correa, Jr., S. Kumar, F. Görlitz, C. Dunsby, P. M. W. French, G. A. Rutter, T. Tan, S. R. Bloom, A. Tomas, B. Jones, The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists. ACS Pharmacol Transl Sci 3, 345-360 (2020). https://doi.org/10.1021/acsptsci.0c00022 Finger, S., A. M. Kerth, M. Dathe, A. Blume, The impact of non-ideality of lipid mixing on peptide induced lipid clustering. Biochim Biophys Acta Biomembr 1862, 183248 (2020). https://doi.org/10.1016/j.bbamem.2020.183248 Finkenwirth, F., M. Sippach, S. N. Pecina, M. Gade, J. Ruta, A. Ricke, E. Bondarenko, J. P. Klare, M. Zinke, S. Lange, A. Lange, H. J. Steinhoff, T. Eitinger, Dynamic interactions of CbiN and CbiM trigger activity of a cobalt energy- coupling-factor transporter. Biochim Biophys Acta Biomembr 1862, 183114 (2020). https://doi.org/10.1016/j.bbamem.2019.183114 Friedrich, D., F. N. Brünig, A. J. Nieuwkoop, R. R. Netz, P. Hegemann, H. Oschkinat, Collective exchange processes reveal an active site proton cage in bacteriorhodopsin. Communications Biology 3, 4 (2020). https://doi.org/10.1038/s42003-019-0733-7 Friedrich, D., J. Perodeau, A. J. Nieuwkoop*, H. Oschkinat*, MAS NMR detection of hydrogen bonds for protein secondary structure characterization. J Biomol NMR 74, 247-256 (2020). https://doi.org/10.1007/s10858-020- 00307-z Furkert, D., S. Hostachy, M. Nadler-Holly, D. Fiedler, Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome. Cell Chem Biol 27, 1097-1108 (2020). https://doi.org/10.1016/j.chembiol.2020.07.017 Furkert, D., M. Nadler-Holly, D. Fiedler, Affinity-enrichment and identification of inositol poly- and pyrophosphate interactomes. STAR Methods in press, (2020). Gallrein§, C., M. Iburg§, T. Michelberger, A. Kocak, D. Puchkov, F. Liu, S. M. Ayala Mariscal, T. Nayak, G. S. Kaminski Schierle, J. Kirstein, Novel Amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity. Prog Neurobiol Online ahead of print, 101907 (2020). https://doi.org/10.1016/j.pneurobio.2020.101907 Gericke, B., K. Römermann, A. f. Noack, S. Noack, J. Kronenberg, I. E. Blasig*, W. Löscher*, A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies. Fluids and barriers of the CNS 17, 53 (2020). https://doi.org/10.1186/s12987-020-00212-5 Gerland*, L., D. Friedrich, L. Hopf, E. J. Donovan, A. Wallmann, N. Erdmann, A. Diehl, M. Bommer, K. Buzar, M. Ibrahim, P. Schmieder, H. Dobbek, A. Zouni, A. N. Bondar, H. Dau, H. Oschkinat*, pH-Dependent Protonation of Surface Carboxylate Groups in PsbO Enables Local Buffering and Triggers Structural Changes. ChemBioChem 21, 1597-1604 (2020). https://doi.org/10.1002/cbic.201900739 Gonschior, H., V. Haucke, M. Lehmann, Super-Resolution Imaging of Tight and Adherens Junctions: Challenges and Open Questions. Int J Mol Sci 21, 544 (2020). Review, https://doi.org/10.3390/ijms21030744 Gonzalez-Lozano, M. A., F. Koopmans, P. F. Sullivan, J. Protze, G. Krause, M. Verhage, K. W. Li*, F. Liu#*, A. B. Smit#*, Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions. Sci Adv 6, eaax5783 (2020). https://doi.org/10.1126/sciadv.aax5783 Göppner, C., A. H. Soria, M. B. Hoegg-Beiler, T. J. Jentsch, Cellular basis of ClC-2 Cl- channel-related brain and testis pathologies. J Biol Chem in press (2020). https://doi.org/10.1074/jbc.RA120.016031 Gowrisankaran, S., S. Houy, J. G. P. del Castillo, V. Steubler, M. Gelker, J. Kroll, P. S. Pinheiro, D. Schwitters, N. Halbsgut, A. Pechstein, J. R. T. van Weering, T. Maritzen, V. Haucke, N. Raimundo, J. B. Sorensen, I. Milosevic, Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin. Nat Commun 11, 1266 (2020). https://doi.org/10.1038/s41467-020-14993-8 Hackenberger, C. P. R., P. E. Dawson, Y. X. Chen, H. Hojo, Modern Peptide and Protein Chemistry: Reaching New Heights. J Org Chem 85, 1328-1330 (2020). Editorial, https://doi.org/10.1021/acs.joc.0c00104 Haenig, C., N. Atias, A. K. Taylor, A. Mazza, M. H. Schaefer, J. Russ, S. P. Riechers, S. Jain, M. Coughlin, J. F. Fontaine, B. D. Freibaum, L. Brusendorf, M. Zenkner, P. Porras, M. Stroedicke, S. Schnoegl, K. Arnsburg, A. Boeddrich, L. Pigazzini, P. Heutink, J. P. Taylor, J. Kirstein, M. A. Andrade-Navarro, R. Sharan, E. E. Wanker, Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Cell Rep 32, 108050 (2020). https://doi.org/10.1016/j.celrep.2020.108050 Hauser, A., S. Hwang, H. Sun*, C. P. R. Hackenberger*, Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase. Chem Sci (2020). https://doi.org/10.1039/D0SC03930F Hauser, A., E. Poulou, F. Müller, P. Schmieder, C. P. R. Hackenberger, Synthesis and evaluation of non- hydrolyzable phospho-lysine peptide mimics. Chemistry Online ahead of print, (2020). https://doi.org/10.1002/chem.202003947 Hecht-Höger, A. M., B. C. Braun, E. Krause, A. Meschede, R. Krahe, C. C. Voigt, A. D. Greenwood, G. A. Czirjak, Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans. Mol Ecol 29, 1745-1755 (2020). https://doi.org/10.1111/mec.15437 Heidenreich, S., P. Weber, H. Stephanowitz, K. M. Petricek, T. Schütte, M. Oster, A. M. Salo, M. Knauer, I. Goehring, N. Yang, N. Witte, A. Schumann, M. Sommerfeld, M. Muenzner, J. Myllyharju, E. Krause, M. Schupp, The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation. J Biol Chem 295, 17158- 17168 (2020). https://doi.org/10.1074/jbc.RA120.014402 Hempel, C., J. Protze, E. Altun, B. Riebe , A. Piontek, A. Fromm , I. M. Lee, T. Saleh, D. Günzel, G. Krause, J. Piontek*, Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner. J Mol Biol 432, 2405-2427 (2020). https://doi.org/10.1016/j.jmb.2020.02.034 Hoffmann, J., J. Ruta, C. Shi, K. Hendriks, V. Chevelkov, W. T. Franks, H. Oschkinat, K. Giller, S. Becker, A. Lange, Protein resonance assignment by BSH-CP based 3D solid-state NMR experiments: A practical guide. Magn Reson Chem 58, 445-465 (2020). https://doi.org/10.1002/mrc.4945 Iburg, M., D. Puchkov, I. U. Rosas-Brugada, L. Bergemann, U. Rieprecht, J. Kirstein, The noncanonical small heat shock protein HSP-17 from Caenorhabditis elegans is a selective protein aggregase. J Biol Chem 295, 3064-3079 (2020). https://doi.org/10.1074/jbc.RA119.011185 Jäpel, M., F. Gerth, T. Sakaba, J. Bacetic, L. J. Yao, S. J. Koo, T. Maritzen, C. Freund, V. Haucke, Intersectin- Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission. Cell Rep 30, 409-420 (2020). https://doi.org/10.1016/j.celrep.2019.12.035 Jayapaul, J., L. Schröder, Probing Reversible Guest Binding with Hyperpolarized (129)Xe-NMR: Characteristics and Applications for Cucurbit[n]urils. Molecules 25, 957 (2020). Review, https://doi.org/10.3390/molecules25040957 Jayapaul, J., L. Schröder, Molecular Sensing with Host Systems for Hyperpolarized (129)Xe. Molecules 25, 4627 (2020). Review, https://doi.org/10.3390/molecules25204627 Kasper*, M. A., M. Gerlach, A. F. L. Schneider, C. Groneberg, P. Ochtrop, S. Boldt, D. Schumacher, J. Helma, H. Leonhardt, M. Christmann, C. P. R. Hackenberger*, N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates. ChemBioChem 21, 113-119 (2020). https://doi.org/10.1002/cbic.201900587 Kircher, T., T. Pantsar, A. Oder, J. P. von Kries, M. Juchum, B. Pfaffenrot, P. Kloevekorn, W. Albrecht, R. Selig, S. Laufer, Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4. Eur J Med Chem Online ahead of print, 112901 (2020). https://doi.org/10.1016/j.ejmech.2020.112901 Kobbersmed, J. R. L., A. T. Grasskamp, M. Jusyte, M. A. Böhme, S. Ditlevsen, J. B. Sorensen*, A. M. Walter*, Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances. Elife 9, e51032 (2020). https://doi.org/10.7554/eLife.51032 Kohn, J. M., J. Riedel, J. Horsch, H. Stephanowitz, H. G. Börner, Mussel-Inspired Polymerization of Peptides: The Chemical Activation Route as Key to Broaden the Sequential Space of Artificial Mussel-Glue Proteins. Macromol Rapid Comm 41, e1900431 (2020). https://doi.org/10.1002/marc.201900431 Krause*, G., K. M. Hinz, Molecular Mechanisms of Thyroid Hormone Transport by l-Type Amino Acid Transporter. Exp Clin Endocrinol Diab 128, 379-382 (2020). Review, https://doi.org/10.1055/a-1032-8369 Kroll, J., O. D. Özcete, S. Jung, T. Maritzen, I. Milosevic, C. Wichmann, T. Moser, AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells. J Cell Sci 133, jcs236737 (2020). https://doi.org/10.1242/jcs.236737 Kuijpers, M., G. Kochlamazashvili, A. Stumpf, D. Puchkov, A. Swaminathan, M. T. Lucht, E. Krause, T. Maritzen, D. Schmitz, V. Haucke, Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron 109, 1-15 (2020). https://doi.org/10.1016/j.neuron.2020.10.005 Kunth, M., L. Schröder*, Binding Site Exchange Kinetics Revealed Through Efficient Spin-Spin Dephasing of Hyperpolarized 129Xe. Chem Sci in print, (2020). https://doi.org/10.1039/d0sc04835f Kutle, I., K. M. Szymanska-de Wijs, B. Bogdanow, B. Cuvalo, L. Steinbrück, S. Jonjic, K. Wagner, R. Niedenthal, M. Selbach, L. Wiebusch, M. Dezeljin, M. Messerle, Murine cytomegalovirus M25 proteins sequester the tumor suppressor protein p53 in nuclear accumulations. J Virol Online ahead of print, (2020). https://doi.org/10.1128/JVI.00574-20 Laezer, I., S. E. Palma-Vera, F. Liu, M. Frank, N. Trakooljul, A. Vernunft, J. Schoen, S. Chen, Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period. Reproduction 159, 371-382 (2020). https://doi.org/10.1530/Rep-19-0219 Lämmle, C. A., A. Varady, T. G. Müller, C. Sturtzel, M. Riepl, B. Mathes, J. Eichhorst, A. Sporbert, M. Lehmann, H. G. Kräusslich, M. Distel, J. Broichhagen, Photocaged Hoechst Enables Subnuclear Visualization and Cell Selective Staining of DNA in vivo. ChemBioChem 21, 1-10 (2020). https://doi.org/10.1002/cbic.202000465 Lauster§, D., S. Klenk§, K. Ludwig, S. Nojoumi, S. Behren, L. Adam, M. Stadtmüller, S. Saenger, S. Zimmler, K. Honzke, L. Yao, U. Hoffmann, M. Bardua, A. Hamann, M. Witzenrath, L. E. Sander, T. Wolff, A. C. Hocke, S. Hippenstiel, S. De Carlo, J. Neudecker, K. Osterrieder, N. Budisa, R. R. Netz, C. Böttcher, S. Liese*, A. Herrmann*, C. P. R. Hackenberger*, Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry. Nat Nanotechnol 15, 373-379 (2020). https://doi.org/10.1038/s41565-020-0660-2 Leippe§, P., J. Broichhagen§, K. Cailliau, A. Mougel, M. Morel, C. Dissous, D. Trauner, J. Vicogne, Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors. Angew Chem Int Ed 59, 6720-6723 (2020). Communications, https://doi.org/10.1002/anie.201915352 Li, M., R. Puschmann, A. Herdlitschka, D. Fiedler, H. Wennemers, Delivery ofmyo-Inositol Hexakisphosphate to the Cell Nucleus with a Proline-Based Cell-Penetrating Peptide. Angew Chem Int Ed 59, 15586-15589 (2020). https://doi.org/10.1002/anie.202006770 Li, X. Y., C. F. Gu, S. Hostachy, S. Sahu, C. Wittwer, H. J. Jessen, D. Fiedler, H. C. Wang, S. B. Shears, Control of XPR1- dependent cellular phosphate efflux by InsP(8) is an exemplar for functionally-exclusive inositol pyrophosphate signaling. Proc. Natl. Acad. Sci. U.S.A. 117, 3568-3574 (2020). https://doi.org/10.1073/pnas.1908830117 Li§, X. L., L. P. Chi§, A. Navarro-Vazquez, S. Hwang, P. Schmieder, X. M. Li, X. Li, S. Q. Yang, X. X. Lei*, B. G. Wang*, H. Sun*, Stereochemical Elucidation of Natural Products from Residual Chemical Shift Anisotropies in a Liquid Crystalline Phase. J Am Chem Soc 142, 2301-2309 (2020). https://doi.org/10.1021/jacs.9b10961 Liu, H., P. Chen, X. L. Li, H. Sun, X. X. Lei*, Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules. Magn Reson Chem 58, 404-410 (2020). https://doi.org/10.1002/mrc.4825 Liu, H., M. N. Paddock, H. Wang, C. J. Murphy, R. C. Geck, A. J. Navarro, G. M. Wulf, O. Elemento, V. Haucke, L. C. Cantley, A. Toker, The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. Cancer Discovery 10, 1226-1239 (2020). https://doi.org/10.1158/2159-8290 Lopez-Hernandez*, T., T. Maritzen*, V. Haucke*, Ramping up the autophagy-lysosome system to cope with osmotic stress. Autophagy 16, 1921-1922 (2020). https://doi.org/10.1080/15548627.2020.1798065 Lopez-Hernandez*, T., D. Puchkov, E. Krause, T. Maritzen*, V. Haucke*, Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis. Nat Cell Biol 22, 815-827 (2020). https://doi.org/10.1038/s41556- 020-0535-7 Maaßen, A., J. M. Gebauer, E. T. Abraham, I. Grimm, J. M. Neudorfl, R. Kühne, I. Neundorf, U. Baumann, H. G. Schmalz, Triple-Helix-Stabilizing Effects in Collagen Model Peptides Containing PPII-Helix-Preorganized Diproline Modules. Angew Chem Int Ed 59, 5747-5755 (2020). https://doi.org/10.1002/anie.201914101 Matthaeus, C., I. Lahmann, S. Kunz, W. Jonas, A. A. Melo, M. Lehmann, E. Larsson, R. Lundmark, M. Kern, M. Bluher, H. Olschowski, J. Kompa, B. Brügger, D. N. Müller, V. Haucke, A. Schürmann, C. Birchmeier, O. Daumke, EHD2-mediated restriction of caveolar dynamics regulates cellular fatty acid uptake. Proc Natl Acad Sci USA 117, 7471-7481 (2020). https://doi.org/10.1073/pnas.1918415117 Morrison, E., T. Wegner, A. E. Zucchetti, M. Alvaro-Benito, A. Zheng, S. Kliche, E. Krause, B. Brugger, C. Hivroz, C. Freund, Dynamic palmitoylation events following T-cell receptor signaling. Communications Biology 3, 368 (2020). https://doi.org/10.1038/s42003-020-1063-5 Mostinski, Y., G. Heynen, M. P. Lopez-Alberca, J. Paul, S. Miksche, S. Radetzki, D. Schaller, E. Shanina, C. Seyffarth, Y. Kolomeets, N. Ziebart, J. de Schryver, S. Oestreich, M. Neuenschwander, Y. Roske, U. Heinemann, C. Rademacher, A. Volkamer, J. P. von Kries, W. Birchmeier, M. Nazare, From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem Online ahead of print, (2020). https://doi.org/10.1021/acs.jmedchem.0c01265 Nakamura, R., T. Numata, G. Kasuya*, T. Yokoyama, T. Nishizawa, T. Kusakizako, T. Kato, T. Hagino, N. Dohmae, M. Inoue, K. Watanabe, H. Ichijo, M. Kikkawa, M. Shirouzu, T. J. Jentsch, R. Ishitani, Y. Okada, O. Nureki, Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation. Commun Biol 3, 240 (2020). https://doi.org/10.1038/s42003-020-0951-z Nematian-Ardestani, E., F. Abd-Wahab, F. C. Chatelain, H. Sun, M. Schewe, T. Baukrowitz, S. J. Tucker, Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel. J Biol Chem 295, 610-618 (2020). https://doi.org/10.1074/jbc.RA119.010612 Ochtrop, P., C. P. R. Hackenberger, Recent advances of thiol-selective bioconjugation reactions. Curr Opin Chem Biol 58, 28-36 (2020). Review, https://doi.org/10.1016/j.cbpa.2020.04.017 Pavulraj, S., M. Kamel, H. 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§, # equal contribution; * corresponding author(s); bold: FMP members

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2016  top

§, # equal contribution; * corresponding author(s); bold: FMP members

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Essays Biochem 60, 153- 161 (2016). Review, https://doi.org/10.1042/Ebc20160002 Seifert, W., Y. Posor, P. Schu, G. Stenbeck, S. Mundlos, S. Klaassen, P. Nürnberg, V. Haucke, U. Kornak, J. Kühnisch, The progressive ankylosis protein ANK facilitates clathrin- and adaptor-mediated membrane traffic at the trans- Golgi network-to-endosome interface. Hum Mol Genet 25, 3836-3848 (2016). https://doi.org/10.1093/hmg/ddw230 Song, K., G. Russo, M. Krauss, Septins As Modulators of Endo-Lysosomal Membrane Traffic. Front Cell Dev Biol 4, 124 (2016). Review, https://doi.org/UNSP 124 10.3389/fcell.2016.00124 Soto, M., M. Hiller, H. Oschkinat, K. Koschek, Multifunctional Benzoxazines Feature Low Polymerization Temperature and Diverse Polymer Structures. Polymers-Basel 8, 278 (2016). https://doi.org/10.3390/polym8080278 Soykan, T., T. Maritzen*, V. Haucke*, Modes and mechanisms of synaptic vesicle recycling. Curr Opin Neurobiol 39, 17-23 (2016). Review, https://doi.org/10.1016/j.conb.2016.03.005 Soykan*, T., V. Haucke*, Membrane kiss mediates hormone secretion. Nature 534, 479-480 (2016). Editorial, https://doi.org/DOI 10.1038/nature18446 Spiesschaert, B., H. Stephanowitz, E. Krause, N. Osterrieder, W. Azab, Glycoprotein B of equine herpesvirus type 1 has two recognition sites for subtilisin-like proteases that are cleaved by furin. J Gen Virol 97, 1218-1228 (2016). https://doi.org/10.1099/jgv.0.000418 Steidle, E. A., L. S. Chong, M. X. Wu, E. Crooke, D. Fiedler, A. C. Resnick*, R. J. Rolfes, A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE - PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5). J Biol Chem 291, 6772-6783 (2016). https://doi.org/10.1074/jbc.M116.714907 Stempel, A. V., A. Stumpf, H. Y. Zhang, T. Ozdogan, U. Pannasch, A. K. Theis, D. M. Otte, A. Wojtalla, I. Racz, A. Ponomarenko, Z. X. Xi, A. Zimmer, D. Schmitz, Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus. Neuron 90, 795-809 (2016). https://doi.org/10.1016/j.neuron.2016.03.034 Stöppler, D., C. Song, B. J. van Rossum, M. A. Geiger, C. Lang, M. A. Mroginski, A. P. Jagtap, S. T. Sigurdsson, J. Matysik, J. Hughes, H. Oschkinat, Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome Photoreceptors. Angew Chem Int Ed 55, 16017-16020 (2016). https://doi.org/10.1002/anie.201608119 Stützer, A., S. Liokatis, A. Kiesel, D. Schwarzer, R. Sprangers, J. Söding, P. Selenko*, W. Fischle, Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails. Mol Cell 61, 247-259 (2016). https://doi.org/10.1016/j.molcel.2015.12.015 Sydow, K., H. Nikolenko, D. Lorenz, R. H. Müller, M. Dathe, Lipopeptide-based micellar and liposomal carriers: Influence of surface charge and particle size on cellular uptake into blood brain barrier cells. Eur J Pharm Biopharm 109, 130-139 (2016). https://doi.org/10.1016/j.ejpb.2016.09.019 Theillet, F. X., A. Binolfi, B. Bekei, A. Martorana, H. M. Rose, M. Stuiver, S. Verzini, D. Lorenz, M. van Rossum, D. Goldfarb, P. Selenko, Structural disorder of monomeric alpha-synuclein persists in mammalian cells. Nature 530, 45-50 (2016). https://doi.org/10.1038/nature16531 Tsvetkova, Y., N. Beztsinna, J. Jayapaul, M. Weiler, S. Arns, Y. Shi, T. Lammers, F. Kiessling, Refinement of adsorptive coatings for fluorescent riboflavin-receptor-targeted iron oxide nanoparticles. Contrast Media Mol I 11, 47-54 (2016). https://doi.org/10.1002/cmmi.1657 Tuttle, M. D., G. Comellas, A. J. Nieuwkoop, D. J. Covell, D. A. Berthold, K. D. Kloepper, J. M. Courtney, J. K. Kim, A. M. Barclay, A. Kendall, W. Wan, G. Stubbs, C. D. Schwieters, V. M. Y. Lee, J. M. George, C. M. Rienstra, Solid- state NMR structure of a pathogenic fibril of full-length human alpha-synuclein. Nat Struct Mol Biol 23, 409-415 (2016). https://doi.org/10.1038/nsmb.3194 Ullrich§, F., S. M. Reincke§, F. K. Voss, T. Stauber, T. J. Jentsch*, Inactivation and Anion Selectivity of Volume- regulated Anion Channels (VRACs) Depend on C-terminal Residues of the First Extracellular Loop. J Biol Chem 291, 17040-17048 (2016). https://doi.org/10.1074/jbc.M116.739342 Wu, M. X., L. S. Chong, D. H. Perlman, A. C. Resnick, D. Fiedler, Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms. Proc Natl Acad Sci USA 113, E6757-E6765 (2016). https://doi.org/10.1073/pnas.1606853113 Yates§, L. M., D. Fiedler*, A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins. ACS Chem Biol 11, 1066-1073 (2016). Article https://doi.org/10.1021/acschembio.5b00972 Zachariassen§, L. G., L. Katchan§, A. G. Jensen, D. S. Pickering, A. J. R. Plested*, A. S. Kristensen*, Structural rearrangement of the intracellular domains during AMPA receptor activation. Proc Natl Acad Sci USA 113, E3950-E3959 (2016). https://doi.org/10.1073/pnas.1601747113 Zong, W., G. W. Li, J. M. Cao, X. X. Lei*, M. L. Hu, H. Sun*, C. Griesinger, R. X. Tan*, An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes. Angew Chem Int Ed 55, 3690-3693 (2016). https://doi.org/10.1002/anie.201511435

2015  top

§, # equal contribution; * corresponding author(s); bold: FMP members

Agrawal, D., C. P. R. Hackenberger, in Chemistry of Organo-hybrids: Synthesis and Characterization of Functional Nano-Objects, B. Charleux, C. Coporet, E. Lacote, Eds. (Wiley, 2015). Book Chapter Albert, G. I., C. Schell, K. M. Kirschner, S. Schäfer, R. Naumann, A. Müller, O. Kretz, B. Kuropka, M. Girbig, N. Hübner, E. Krause, H. Scholz*, T. B. Huber*, K. P. Knobeloch, C. Freund, The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function. J Mol Cell Biol 7, 402-414 (2015). https://doi.org/10.1093/jmcb/mjv039 Alvaro-Benito, M., M. Wieczorek, J. Sticht, C. Kipar, C. Freund, HLA-DMA Polymorphisms Differentially Affect MHC Class II Peptide Loading. J Immunol 194, 803-816 (2015). https://doi.org/10.4049/jimmunol.1401389 Balletta, A., D. Lorenz, A. Rummel, R. Gerhard, H. Bigalke, F. Wegner, Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca2+ and GTP gamma S. Toxicology 328, 48-56 (2015). https://doi.org/10.1016/j.tox.2014.12.006 Bender§, F., M. Gorbati§, M. Carus-Cadavieco, N. Denisova, X. J. Gao, C. Holman, T. Korotkova*, A. Ponomarenko*, Theta oscillations regulate the speed of locomotion via a hippocampus to lateral septum pathway. Nat Commun 6, 8521 (2015). https://doi.org/10.1038/ncomms9521 Bertran-Vicente, J., M. Schümann, P. Schmieder, E. Krause, C. P. R. Hackenberger, Direct access to site-specifically phosphorylated-lysine peptides from a solid-support. Org Biomol Chem 13, 6839-6843 (2015). https://doi.org/10.1039/c5ob00734h Bertran-Vicente*, J., M. Schümann, C. P. R. Hackenberger, E. Krause*, Gas-Phase Rearrangement in Lysine Phosphorylated Peptides During Electron-Transfer Dissociation Tandem Mass Spectrometry. Anal Chem 87, 6990-6994 (2015). https://doi.org/10.1021/acs.analchem.5b01389 Broncel, M., R. A. Serwa, P. Ciepla, E. Krause, M. J. Dallman, A. I. Magee, E. W. Tate, Multifunctional Reagents for Quantitative Proteome-Wide Analysis of Protein Modification in Human Cells and Dynamic Profiling of Protein Lipidation During Vertebrate Development. Angew Chem Int Ed 54, 5948-5951 (2015). https://doi.org/10.1002/anie.201500342 Broncel, M., R. A. Serwa, P. Ciepla, E. Krause, M. J. Dallman, A. I. Magee, E. W. Tate, Myristoylation profiling in human cells and zebrafish. Data Brief 4, 379-383 (2015). https://doi.org/10.1016/j.dib.2015.06.010 Bruun, S., D. Stoeppler, A. Keidel, U. Kuhlmann, M. Luck, A. Diehl, M. A. Geiger, D. Woodmansee, D. Trauner, P. Hegemann, H. Oschkinat*, P. Hildebrandt*, K. Stehfest*, Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion between the all-trans and 13-cis Retinal Isomers. Biochemistry-Us 54, 5389-5400 (2015). https://doi.org/10.1021/acs.biochem.5b00597 Cai, Y. Y., E. N. Postnikova, J. G. Bernbaum, S. Q. Yu, S. Mazur, N. M. Deiuliis, S. R. Radoshitzky, M. G. Lackemeyer, A. McCluskey, P. J. Robinson, V. Haucke, V. Wahl-Jensen, A. L. Bailey, M. Lauck, T. C. Friedrich, D. H. O'Connor, T. L. Goldberg, P. B. Jahrling, J. H. Kuhna*, Simian Hemorrhagic Fever Virus Cell Entry Is Dependent on CD163 and Uses a Clathrin-Mediated Endocytosis-Like Pathway. J Virol 89, 844-856 (2015). https://doi.org/10.1128/Jvi.02697-14 Chevelkov*, V., S. Q. Xiang, K. Giller, S. Becker, A. Lange, B. Reif, Perspectives for sensitivity enhancement in proton-detected solid-state NMR of highly deuterated proteins by preserving water magnetization. J Biomol NMR 61, 151-160 (2015). https://doi.org/10.1007/s10858-015-9902-2 Cording, J., R. Günther, E. Vigolo, C. Tscheik, L. Winkler, I. Schlattner, D. Lorenz, R. F. Haseloff, K. M. Schmidt-Ott, H. Wolburg, I. E. Blasig, Redox Regulation of Cell Contacts by Tricellulin and Occludin: Redox-Sensitive Cysteine Sites in Tricellulin Regulate Both Tri- and Bicellular Junctions in Tissue Barriers as Shown in Hypoxia and Ischemia. Antioxid Redox Sign 23, 1035-1049 (2015). 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Trnka, S. Waiczies, T. Niendorf, W. B. Stallcup, R. Glass, E. Krause, T. Maritzen, Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility. Nat Commun 6, 8535 (2015). https://doi.org/10.1038/ncomms9535 Fidzinski§, P., T. Korotkova§, M. Heidenreich§, N. Maier, S. Schuetze, O. Kobler, W. Zuschratter, D. Schmitz, A. Ponomarenko, T. J. Jentsch, KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations. Nat Commun 6, 6254 (2015). https://doi.org/10.1038/ncomms7254 Finger, S., A. Kerth, M. Dathe, A. Blume, The efficacy of trivalent cyclic hexapeptides to induce lipid clustering in PG/PE membranes correlates with their antimicrobial activity. Biochim Biophys Acta-Biomembr 1848, 2998- 3006 (2015). https://doi.org/10.1016/j.bbamem.2015.09.012 Fischer, J., G. Kleinau, A. Müller, P. Kuehnen, D. Zwanziger, A. Kinne, M. Rehders, L. C. Moeller, D. Führer, A. Grüters, H. Krude, K. Brix, H. Biebermann, Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations. J Mol Endocrinol 54, 39-50 (2015). https://doi.org/10.1530/Jme-14-0272 Fricke, P., V. Chevelkov, C. W. Shi, A. Lange, Strategies for solid-state NMR investigations of supramolecular assemblies with large subunit sizes. J Magn Reson 253, 2-9 (2015). https://doi.org/10.1016/j.jmr.2014.10.018 Gattin, Z., R. Schneider, Y. Laukat, K. Giller, E. Maier, M. Zweckstetter, C. Griesinger, R. Benz, S. Becker, A. Lange, Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. J Biomol NMR 61, 311-320 (2015). https://doi.org/10.1007/s10858-014-9876-5 Gehne, N., R. F. Haseloff, I. E. Blasig, Identity crisis in the PMP-22/EMP/MP20/Claudin superfamily (Pfam00822). Tissue Barriers 3, (2015). Letter, https://doi.org/10.1080/21688370.2015.1089680 Gimber, N., G. Tadeus, T. Maritzen, J. Schmoranzer, V. Haucke, Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins. Nat Commun 6, 8392 (2015). https://doi.org/10.1038/ncomms9392 Goody, R., V. Haucke, W. Just, FEBS Lett 589, 1515 (2015). Editorial, https://doi.org/10.1016/j.febslet.2015.05.011 Grosskopf, S., C. Eckert, C. Arkona, S. Radetzki, K. Böhm, U. Heinemann, G. Wolber, J. P. von Kries, W. Birchmeier, J. Rademann, Selective Inhibitors of the Protein Tyrosine Phosphatase SHP2 Block Cellular Motility and Growth of Cancer Cells in vitro and in vivo. ChemMedChem 10, 815-826 (2015). https://doi.org/10.1002/cmdc.201500015 Grzesik, P., A. Kreuchwig, C. Rutz, J. Furkert, B. Wiesner, R. Schülein, G. Kleinau, J. Gromoll, G. Krause, Differences in signal activation by LH and hcg are mediated by the LH/CG receptor's extracellular hinge region. Front Endocrinol 6, (2015). https://doi.org/10.3389/fendo.2015.00140 Günther, R., E. Krause, M. Schümann, I. E. Blasig, R. F. 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Sci Rep 5, 16604 (2015). https://doi.org/10.1038/srep16604 Henning, L. M., S. Bhatia, M. Bertazzon, M. Marczynke, O. Seitz, R. Volkmer, R. Haag, C. Freund, Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW. Beilstein J Org Chem 11, 701-706 (2015). https://doi.org/10.3762/bjoc.11.80 Herrada, I., C. Samson, C. Velours, L. Renault, C. Ostlund, P. Chervy, D. Puchkov, H. J. Worman, B. Buendia, S. Zinn- Justin, Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties. ACS Chem Biol 10, 2733-2742 (2015). https://doi.org/10.1021/acschembio.5b00648 Hinz, K. M., K. Meyer, A. Kinne, R. Schülein, J. Köhrle, G. Krause, Structural Insights Into Thyroid Hormone Transport Mechanisms of the L-Type Amino Acid Transporter 2. Mol Endocrinol 29, 933-942 (2015). https://doi.org/10.1210/me.2015-1044 Hu, H. Y., N. H. Lim, D. Ding-Pfennigdorff, J. Saas, K. U. Wendt, O. Ritzeler, H. Nagase, O. Plettenburg, C. Schultz*, M. 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Cieslicki, Is transmission electron microscopy (TEM) a promising approach for qualitative and quantitative investigations of polymyxin B and miconazole interactions with cellular and subcellular structures of Staphylococcus pseudintermedius, Escherichia coli, Pseudomonas aeruginosa and Malassezia pachydermatis? Vet Microbiol 181, 261-270 (2015). https://doi.org/10.1016/j.vetmic.2015.10.002 Waiczies*§, S., S. Lepore*§, K. Sydow*§, S. Drechsler, M. C. Ku, C. Martin, D. Lorenz, I. Schütz, H. M. Reimann, B. Purfürst, M. A. Dieringer, H. Waiczies, M. Dathe, A. Pohlmann, T. Niendorf, Anchoring Dipalmitoyl Phosphoethanolamine to Nanoparticles Boosts Cellular Uptake and Fluorine-19 Magnetic Resonance Signal. Sci Rep 5, 8427 (2015). https://doi.org/10.1038/srep08427 Wang, X. Q., M. Chong, X. Wang, H. K. Wang, J. Zhang, H. Xu, J. J. Zhang*, D. Liu, Block the function of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardia bifida. In Vitro Cell Dev-An 51, 211-217 (2015). https://doi.org/10.1007/s11626-014-9836-0 Wang, Y., M. D. V. Moreira, S. Heringer-Walther, H. P. Schultheiss, W. E. Siems, N. Wessel, T. Walther, Beta Blockers Prevent Correlation of Plasma ACE2 Activity With Echocardiographic Parameters in Patients With Idiopathic Dilated Cardiomyopathy. J Cardiovasc Pharm 65, 8-12 (2015). https://doi.org/Doi 10.1097/Fjc.0000000000000156 Weng, A., M. D. I. Manunta, M. Thakur, R. Gilabert-Oriol, A. D. Tagalakis, A. Eddaoudi, M. M. Munye, C. A. Vink, B. Wiesner, J. Eichhorst, M. F. Melzig, S. L. Hart, Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides. J Control Release 206, 75-90 (2015). https://doi.org/10.1016/j.jconrel.2015.03.007 Williams, C., L. Opalinski, C. Landgraf, J. Costello, M. Schrader, A. M. Krikken, K. Knoops, A. M. Kram, R. Volkmer, J. van der Klei, The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission. Proc Natl Acad Sci USA 112, 6377-6382 (2015). https://doi.org/10.1073/pnas.1418736112 Witte§, C., V. Martos§, H. M. Rose, S. Reinke, S. Klippel, L. Schröder*, C. P. R. Hackenberger*, Live-cell MRI with Xenon Hyper-CEST Biosensors Targeted to Metabolically Labeled Cell-Surface Glycans. Angew Chem Int Ed 54, 2806-2810 (2015). https://doi.org/10.1002/anie.201410573 Wu, Y. J., R. Tejero, M. Arancillo, G. Vardar, T. Korotkova, M. Kintscher, D. Schmitz, A. Ponomarenko, L. Tabares, C. Rosenmund, Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. J Neurophysiol 114, 2404-2417 (2015). https://doi.org/10.1152/jn.00577.2015 Zevenbergen, C., M. E. Meima, E. C. L. de Souza, R. P. Peeters, A. Kinne, G. Krause, W. E. Visser, T. J. Visser, Transport of Iodothyronines by Human L-Type Amino Acid Transporters. Endocrinology 156, 4345-4355 (2015). https://doi.org/10.1210/en.2015-1140 Zhang*§, J. J., C. Ni§, Z. G. Yang§, A. Piontek, H. P. Chen, S. J. Wang, Y. M. Fan, Z. H. Qin, J. Piontek, Specific binding of Clostridium perfringens enterotoxin fragment to Claudin-b and modulation of zebrafish epidermal barrier. Exp Dermatol 24, 605-610 (2015). https://doi.org/10.1111/exd.12728

2014  top

§, # equal contribution; * corresponding author(s); bold: FMP members

Abel*, S., B. Geltinger, N. Heinrich, D. Michl, A. Klose, M. Beyermann, D. Schwarzer, Semisynthesis and optimization of G protein-coupled receptor mimics. J Pept Sci 20, 831-836 (2014). https://doi.org/10.1002/psc.2680 Akbey*, U., A. J. Nieuwkoop, S. Wegner, A. Voreck, Kunert, B., P. Bandara, F. Engelke, N. C. Nielsen, H. Oschkinat*, Quadruple-Resonance Magic-Angle Spinning NMR Spectroscopy of Deuterated Solid Proteins. Angew Chem Int Ed 53, 2438-2442 (2014). https://doi.org/10.1002/anie.201308927 Arnsburg, K., J. Kirstein-Miles, Interrelation Between Protein Synthesis, Proteostasis and Life Span. Curr Genomics 15, 66-75 (2014). https://doi.org/10.2174/1389202915666140210210542 Barbet-Massin, E., A. J. Pell, J. S. Retel, L. B. Andreas, K. Jaudzems, W. T. Franks, A. J. Nieuwkoop, M. Hiller, V. Higman, P. Guerry, A. Bertarello, M. J. Knight, M. Felletti, T. Le Marchand, S. Kotelovica, I. Akopjana, K. Tars, M. Stoppini, V. Bellotti, M. Bolognesi, S. Ricagno, J. J. Chou, R. G. Griffin, H. Oschkinat, A. Lesage, L. Emsley, T. Herrmann, G. Pintacuda, Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning. J Am Chem Soc 136, 12489-12497 (2014). https://doi.org/10.1021/ja507382j Barvencik, F., I. Kurth, T. Koehne, T. Stauber, J. Zustin, K. Tsiakas, C. F. Ludwig, F. T. Beil, J. M. Pestka, M. Hahn, R. Santer, C. Supanchart, U. Kornak, A. Del Fattore, T. J. Jentsch, A. Teti, A. Schulz, T. Schinke, M. Amling, CLCN7 and TCIRG1 Mutations Differentially Affect Bone Matrix Mineralization in Osteopetrotic Individuals. J Bone Miner Res 29, 982-991 (2014). https://doi.org/DOI 10.1002/jbmr.2100 Basters, A., P. P. Geurink, F. El Oualid, L. Ketscher, M. S. Casutt, E. Krause, H. Ovaa, K. P. Knobeloch, G. Fritz, Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon- stimulated gene 15. FEBS J 281, 1918-1928 (2014). https://doi.org/10.1111/febs.12754 Becker, C. F., A. Brik, P. Dawson, C. P. Hackenberger, Chemical protein synthesis. J Pept Sci 20, 63 (2014). Editorial, https://doi.org/10.1002/psc.2607 Bellmann, C., S. Schreivogel, R. Günther, S. Dabrowski, M. Schümann, H. Wolburg, I. E. Blasig, Highly Conserved Cysteines Are Involved in the Oligomerization of Occludin-Redox Dependency of the Second Extracellular Loop. Antioxid Redox Sign 20, 855-867 (2014). https://doi.org/10.1089/ars.2013.5288 Bertran-Vicente, J., R. A. Serwa, M. Schümann, P. Schmieder, E. Krause, C. P. R. Hackenberger, Site-Specifically Phosphorylated Lysine Peptides. J Am Chem Soc 136, 13622-13628 (2014). https://doi.org/10.1021/ja507886s Biller, L., J. Matthiesen, V. Kühne, H. Lotter, G. Handal, T. Nozaki, Y. Saito-Nakano, M. Schümann, T. Roeder, E. Tannich, E. Krause, I. Bruchhaus, The Cell Surface Proteome of Entamoeba histolytica. Mol Cell Proteomics 13, 132-144 (2014). https://doi.org/10.1074/mcp.M113.031393 Boldron, C., A. Besse, M. F. Bordes, S. Tissandie, X. Yvon, B. Gau, A. Badorc, T. Rousseaux, G. Barre, J. Meneyrol, G. Zech, M. Nazaré, V. Fossey, A. M. Pflieger, S. Bonnet-Lignon, L. Millet, C. Briot, F. Dol, J. P. Herault, P. Savi, G. Lassalle, N. Delesque, J. M. Herbert, F. Bono, N-[6-(4-Butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5- chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist. J Med Chem 57, 7293-7316 (2014). https://doi.org/10.1021/jm500588w Borcherds§, W., F. X. Theillet§, A. Katzer§, A. Finzel, K. M. Mishall, A. T. Powell, H. W. Wu, W. Manieri, C. Dieterich, P. Selenko*, A. Loewer*, G. W. Daughdrill*, Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells. Nat Chem Biol 10, 1000-1002 (2014). https://doi.org/10.1038/nchembio.1668 Chakrabarti, A., J. J. Witsenburg, M. D. Sinzinger, M. Richter, R. Wallbrecher, J. C. Cluitmans, W. P. R. Verdurmen, S. Tanis, M. J. W. Adjobo-Hermans, J. Rademann, R. 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FEBS J 281, 1479-1492 (2014). https://doi.org/10.1111/febs.12718 Günther, R., E. Krause, M. Schümann, J. Ausseil, J. M. Heard, I. E. Blasig, R. F. Haseloff, Removal of albumin and immunoglobulins from canine cerebrospinal fluid using depletion kits: a feasibility study. Fluids Barriers CNS 11, 14 (2014). https://doi.org/10.1186/2045-8118-11-14 Hebel, K., S. Weinert, B. Kuropka, J. Knolle, B. Kosak, G. Jorch, C. Arens, E. Krause, R. C. Braun-Dullaeus, M. C. Brunner-Weinzierl, CD4(+) T Cells from Human Neonates and Infants Are Poised Spontaneously To Run a Nonclassical IL-4 Program. J Immunol 192, 5160-5170 (2014). https://doi.org/10.4049/jimmunol.1302539 Hoegg-Beiler§, M. B., S. Sirisi§, I. J. Orozco§, I. Ferrer, S. Hohensee, M. Auberson, K. Gödde, C. Vilches, M. L. de Heredia, V. Nunes*, R. Estevez*, T. J. Jentsch*, Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction. 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