JOURNAL OF VIROLOGY

Volume 65 October 1991 No. 10

ANIMAL VIRUSES The Virus 1 Gene Encoding a Protease Also Contains within Its Coding Domain the Gene Encoding the More Abundant Substrate. Fenyong Liu and Bernard Roizman...... 5149-5156 An RNA Secondary Structure Juxtaposes Two Remote Genetic Signals for Hu- man T-Cell Leukemia Virus Type I RNA 3'-End Processing. Anat Bar-Shira, Amos Panet, and Alik Honigman ...... 5165-5173 A 15-Kilobase-Pair Region of the Human Cytomegalovirus Genome Which In- cludes US1 through US13 Is Dispensable for Growth in Cell Culture. A. Kollert-Jons, E. Bogner, and K. Radsak...... 5184-5189 Identification of a Signal Necessary for Initiation of Reverse Transcription of the Hepadnavirus Genome. Christoph Seeger and Johnna Maragos ...... 5190-5195 Critical Chemical Features in trans-Acting-Responsive RNA Are Required for In- teraction with Human Immunodeficiency Virus Type 1 Tat . Martin Sumner-Smith, Sophie Roy, Richard Bamett, Lorne S. Reid, Raya Kuperman, Ulrike Delling, and Nahum Sonenberg...... 5196-5202 Characterization of the Bovine Herpesvirus 4 Major Immediate-Early Tran- script. Vicky L. van Santen...... 5211-5224 An Assembly Defect as a Result of an Attenuating Mutation in the Pro- teins of the Poliovirus Type 3 Vaccine Strain. Andrew J. Macadam, Geraldine Ferguson, Catherine Arnold, and Philip D. Minor...... 5225-5231 Zidovudine-Resistant Human Immunodeficiency Virus Selected by Passage in Cell Culture. Brendan A. Larder, Karen E. Coates, and Sharon D. Kemp .... 5232-5236 Mutational Analysis of the Simian Immunodeficiency Virus SIVmac Gene. Dorothea Binninger, Joachim Ennen, Daniela Bonn, Stephen G. Norley, and Reinhard Kurth...... 5237-5243 Regulation of the Biosynthesis of Subgroup C Adenovirus Protein IVa2. Nathalie Winter and Jean-Claude D'Halluin ...... 5250-5259 Cloning of the Latency Gene and the Early Protein 0 Gene of Pseudorabies Virus. Andrew K. Cheung...... 5260-5271 The Hydrophobic Membrane-Spanning Sequences of the gp52 Glycoprotein Are Required for the Pathogenicity of Friend Spleen Focus-Forming Virus. Ranga V. Srinivas, David R. Kilpatrick, Simon Tucker, Zheng Rui, and Richard W. Compans...... 5272-5280 Novel Regulatory Properties of the IEl and IEO Transactivators Encoded by the Baculovirus Autographa californica Multicapsid Nuclear Polyhedrosis Virus. Gerald R. Kovacs, Linda A. Guarino, and Max D. Summers ...... 5281-5288 Characterization of a Potent Varicella-Zoster Virus-Encoded trans-Repressor. Sunil Nagpal and Jeffrey M. Ostrove...... 5289-5296 Identification and Characterization of Intragenic Sequences Which Repress Human Immunodeficiency Virus Structural . Alan W. Cochrane, Kathryn S. Jones, Sary Beidas, Patrick J. Dillon, Anna Marie Skalka, and Craig A. Rosen ...... 5305-5313 A Bovine Papillomavirus El-Related Protein Binds Specifically to Bovine Papillomavirus DNA. Van G. Wilson and John Ludes-Meyers ...... 5314-5322

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Mutational Analysis of N-Linked Glycosylation Sites of Friend Envelope Protein. Samuel C. Kayman, Rebecca Kopelman, Steven Projan, Dennis M. Kinney, and Abraham Pinter...... 5323-5332 Synthesis of Leader RNA and Editing of the P mRNA during Transcription by Purified Virus. Sandra M. Horikami and Sue A. Moyer...... 5342-5347 Identification of a Transactivating Function Mapping to the Putative Immediate- Early Locus of Human Herpesvirus 6. Michelle E. D. Martin, John Nicholas, Brian J. Thomson, Carol Newman, and Robert W. Honess ...... 5381-5390 Recombination of the Internal Direct Repeat Element DR2 Responsible for the Fluidity of the a Sequence of Type 1. Kenichi Umene ...... 5410-5416 Genetic Diversity of the Attachment Protein of Subgroup B Respiratory Syncytial Viruses. Wayne M. Sullender, Maurice A. Mufson, Larry J. Anderson, and Gail W. Wertz ...... 5425-5434 Infection Initiated by the RNA Pregenome of a DNA Virus. Mingjun Huang and Jesse Summers ...... 5435-5439 Nucleotide Sequence and Expression of the Capsid Protein Gene of Feline Calici- virus. John D. Neill, Ilene M. Reardon, and Robert L. Heinrikson ...... 5440-5447 Production of Nucleocapsidlike Core Particles in Xenopus Oocytes: Assembly Occurs Mainly in the Cytoplasm and Does Not Require the Nucleus. Siliang Zhou and David N. Standring ...... 5457-5464 Evolutionary Analysis of the A Virus M Gene with Comparison of the Ml and M2 . Toshihiro Ito, Owen T. Gorman, Yoshihiro Kawaoka, William J. Bean, and Robert G. Webster ...... 5491-5498 Avian Reovirus S1133 Can Replicate in Mouse L Cells: Effect of pH and Cell At- tachment Status on Viral Infection. Moises Mallo, Jose Martinez-Costas, and Javier Benavente...... 5499-5505 The Stimulatory Effect of Actinomycin D on Avian Reovirus Replication in L Cells Suggests that Translational Competition Dictates the Fate of the Infec- tion. Moises Mallo, Jose Martinez-Costas, and Javier Benavente...... 5506-5512 Inhibition of Human Immunodeficiency Virus Type 1 Multiplication by Antisense and Sense RNA Expression. Sadhna Joshi, Alan Van Brunschot, Sabah Asad, Ingrid Van Der Eist, Stanley E. Read, and Alan Bernstein ...... 5524-5530 Resistance to Human Immunodeficiency Virus Type 1 (HIV-1) Infection in Hu- man CD4+ Lymphocyte-Derived Cell Lines Conferred by Using Retroviral Vectors Expressing an HIV-1 RNA-Specific Ribozyme. Migara Weerasinghe, Sian E. Liem, Sabah Asad, Stanley E. Read, and Sadhna Joshi ...... 5531-5534 Comparative Amino Acid Sequence Analysis of VP4 for VP7 Serotype 6 Bovine Strains NCDV, B641, and UK. Michele E. Hardy, Gerald N. Woode, Zhichang Xu, and Mario Gorziglia ...... 5535-5538 Defective Hepatitis B Virus Particles Are Generated by Packaging and Reverse Transcription of Spliced Viral RNAs In Vivo. Sylvie Terre, Marie-Anne Petit, and Christian Brechot...... 5539-5543 Pseudorabies Virus glll and Bovine Herpesvirus 1 glll Share Complementary Functions. Xiaoping Liang, Lorne A. Babiuk, and Tim J. Zamb...... 5553-5557 Characterization of a Novel Human Papillomavirus DNA in the Cervical Carci- noma Cell Line ME180. Stella Reuter, Hajo Delius, Tomas Kahn, Birgit Hofmann, Harald zur Hausen, and Elisabeth Schwarz ...... 5564-5568

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Molecular Characterization of Biologically Diverse Envelope Variants of Human Immunodeficiency Virus Type 1 Derived from an Individual. Rod S. Daniels, Marian H. Smith, and Amanda G. Fisher...... 5574-5578 The Flavivirus Envelope Protein E: Isolation of a Soluble Form from Tick-Borne Encephalitis Virus and Its Crystallization. Franz X. Heinz, Christian W. Mandl, Heidemarie Holzmann, Christian Kunz, Barbara A. Harris, Felix Rey, and Stephen C. Harrison...... 5579-5583 Recovery of Infectious Human Immunodeficiency Virus Type 1 after Fusion of Defectively Infected Clones of U-937 Cells. Franqois Boulerice, Xu Guang Li, Alla Lvovich, and Mark A. Wainberg...... 5589-5592 Identification of the Human Herpesvirus 6 Glycoprotein H and Putative Large Tegument Protein Genes. Steven F. Josephs, Dharam V. Ablashi, S. Zaki Salahuddin, Linda L. Jagodzinski, Flossie Wong-Staal, and Robert C. Gallo ...... 5597-5604 Mouse Hepatitis Virus S RNA Sequence Reveals that Nonstructural Proteins ns4 and Are Not Essential for Murine Coronavirus Replication. Kyoko Yokomori and Michael M. C. Lai...... 5605-5608 The Nucleotide Sequence, 5' End, Promoter Domain, and Kinetics of Expression of the Gene Encoding the Herpes Simplex Virus Type 2 Latency-Associated Transcript. Philip R. Krause, Jeffrey M. Ostrove, and Stephen E. Straus 5619-5623 Substrate Specificity of Recombinant Human Immunodeficiency Virus Protein. Robert L. LaFemina, Pia L. Callahan, and Michael G. Cordingley ...... 5624-5630 Protease Digestion of Hepatitis A Virus: Disparate Effects on Capsid Proteins, Antigenicity, and Infectivity. Stanley M. Lemon, Elizabeth Amphlett, and David Sangar...... 5636-5640

VIRUS-CELL INTERACTIONS Predominant Binding of Theiler's Viruses to a 34-Kilodalton Receptor Protein on Susceptible Cell Lines. David R. Kilpatrick and Howard L. Lipton ...... 5244-5249 Pseudorabies Virus Glycoproteins gll and gp5O Are Essential for Virus Penetra- tion. Isabella Rauh and Thomas C. Mettenleiter...... 5348-5356 Genetic Analysis of the Adenovirus E4 6/7 trans Activator: Interaction with E2F and Induction of a Stable DNA-Protein Complex Are Critical for Activity. Suzanne D. Neill and Joseph R. Nevins ...... 5364-5373 Immune Response and Resistance to Challenge of Chickens Immunized with Cell-Associated Glycoproteins Provided with a Recombinant Avian Leukosis Virus. Yahia Chebloune, Jan Rulka, Francois Lowc Cosset, Sandrine Valsesia, Corinne Ronfort, Catherine Legras, Antoine Drynda, Jacek Kuzmak, Victor Marc Nigon, and Gerard Verdier ...... 5374-5380 PEAl and PEA3 Enhancer Elements Are Primary Components of the Polyomavi- rus Late Transcription Initiator Element. Wangdon Yoo, Mark E. Martin, and William R. Folk...... 5391-5400 Alternative Pathway for Induction of Human Immunodeficiency Virus Gene Expression: Involvement of the General Transcription Machinery. Mamoru Sakaguchi, Beatrice Zenzie-Gregory, Jerome E. Groopman, Stephen T. Smale, and Sunyoung Kim...... 5448-5456

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Modulation of T-Cell Activation through Protein Kinase C- or A-Dependent Sig- nalling Pathways Synergistically Increases Human Immunodeficiency Virus Long Terminal Repeat Induction by Cytomegalovirus Immediate-Early Pro- teins. Carlos V. Paya, Jean-Louis Virelizier, and Susan Michelson...... 5477-5484 Sequence-Specific Interaction of the Etsl Protein with the Long Terminal Repeat of the Human T-Lymphotropic Virus Type I. Scott D. Gitlin, Remy Bosselut, Anne Gegonne, Jacques Ghysdael, and John N. Brady...... 5513-5523 Transcriptional and Posttranscriptional Regulation of Class I Major Histocompat- ibility Complex Genes following Transformation with Human Adenoviruses. Jenny Shemesh, Rinat Rotem-Yehudar, and Rachel Ehrlich ...... 5544-5548 Moloney Leukemia Virus Immortalizes B Lymphocytes In Vitro. Judith Runnels, Leslie Serunian, Michael Thursby, and Naomi Rosenberg ...... 5549-5552 The Epstein-Barr Virus BNLF-1 Membrane Protein LMP1 Induces Homotypic Adhesion Mediated by CD11a/CD18 in a Murine B-Cell Line, Mimicking the Action of Phorbol Ester. Rosalba Salcedo, Sally M. Fuerstenberg, Manuel Patarroyo, and Gosta Winberg ...... 5558-5563 Repression of the Human Papillomavirus Type 18 Enhancer by the Cellular Transcription Factor Oct-1. Felix Hoppe-Seyler, Karin Butz, and Harald zur Hausen...... 5613-5618 Human Immunodeficiency Virus Tat Transactivation: Induction of a Tissue-Spe- cific Enhancer in a Nonpermissive Cell Line. James Remenick, Michael F. Radonovich, and John N. Brady...... 5641-5646

VIRAL AND CELLULAR ONCOGENES The Human DNA-Activated Protein Kinase Phosphorylates Simian Virus 40 T Antigen at Amino- and Carboxy-Terminal Sites. Yuh-Ru Chen, Susan P. Lees-Miller, Peter Tegtmeyer, and Carl W. Anderson ...... 5131-5140 Cellular ras Gene Activity Is Required for Full Neoplastic Transformation by Polyomavirus. Leda Raptis, Richard Marcellus, Michael J. Corbley, Anna Krook, James Whitfield, Stephen K. Anderson, and Tina Haliotis ... 5203-5210 A Purified Adenovirus 289-Amino-Acid ElA Protein Activates RNA Polymerase III Transcription In Vitro and Alters Transcription Factor TFIIIC. Shoumen Datta, Chu-Jing Soong, Duen Mei Wang, and Marian L. Harter 5297-5304 Generation of Recombinant Murine Retroviral Genomes Containing the v-src Oncogene: Isolation of a Virus Inducing Hemangiosarcomas in the Brain. Peter Hevezi and Stephen P. Goff...... 5333-5341 Complex Formation between the Lymphotropic Papovavirus Large Tumor Anti- gen and the Tumor Suppressor Protein p53. Holly Symonds, Jiandong Chen, and Terry Van Dyke ...... 5417-5424 The T/t Common Region of Simian Virus 40 Large T Antigen Contains a Distinct Transformation-Governing Sequence. Erika Marsilio, Seng H. Cheng, Brian Schaffhausen, Eva Paucha, and David M. Livingston...... 5647-5652

VIRAL PATHOGENESIS AND IMMUNITY T-Helper Cell and Associated Antibody Response to Synthetic Peptides of the E Glycoprotein of Murray Valley Encephalitis Virus. James H. Mathews, Jane E. Allan, John T. Roehrig, John R. Brubaker, Michael F. Uren, and Ann R. Hunt ...... 5141-5148

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Role of Immune Cells in Protection against and Control of Reovirus Infection in Neonatal Mice. Herbert W. Virgin IV and Kenneth L. Tyler...... 5157-5164 The Polyomavirus Early Region Gene in Transgenic Mice Causes Vascular and Bone Tumors. Rong Wang and Victoria L. Bautch ...... 5174-5183 Deletion of a GC-Rich Region Flanking the Enhancer Element within the Long Terminal Repeat Sequences Alters the Disease Specificity of Moloney Murine Leukemia Virus. Ronnie Hanecak, Paul K. Pattengale, and Hung Fan.... 5357-5363 Characterization of Two Distinct Major Histocompatibility Complex Class I Kk- Restricted T-Cell Epitopes within the Influenza A/PR/8/34 Virus Hemaggluti- nin. Keith G. Gould, Hilary Scotney, and George G. Brownlee...... 5401-5409 Neuroattenuation of an Avirulent Bunyavirus Variant Maps to the L RNA Seg- ment. Michael J. Endres, Christian Griot, Francisco Gonzalez-Scarano, and Neal Nathanson ...... 5465-5470 Polymerase Chain Reaction Analysis of Defective Human T-Cell Leukemia Virus Type I Proviral Genomes in Leukemic Cells of Patients with Adult T-Cell Leukemia. Bette Korber-r,-Akihiko Okayama, Rachel Donnelly, Nobuyoshi Tachibana, and Myron Essex ...... 5471-5476 Identification and Mapping of Neutralizing Epitopes of Human Parvovirus B19 by Using Human Antibodies. Hiroyuki Sato, Jouji Hirata, Naotaka Kuroda, Hiroshi Shiraki, Yoshiaki Maeda, and Kazuo Okochi ...... 5485-5490 A Herpes Simplex Virus Type 1 Mutant Lacking the ICPO Introns Reactivates with Normal Efficiency. Rajeswari Natarajan, Satish Deshmane, Tibor Valyi-Nagy, Roger Everett, and Nigel W. Fraser...... 5569-5573 Increased Expression In Vivo and In Vitro of Foreign Genes Directed by A-Type Inclusion Body Hybrid Promoters in Recombinant Viruses. Shin-Ichi Funahashi, Shigeyuki Itamura, Hisae linuma, Kuniaki Nerome, Masanobu Sugimoto, and Hisatoshi Shida ...... 5584-5588 Neutralizing Antibodies Induced by Recombinant Vaccinia Virus Expressing Varicella-Zoster Virus gpIV. Abbas Vafai and Weining Yang ...... 5593-5596 Disturbance of Nuclear Transport of Proteins in CD4+ Cells Expressing gpl60 of Human Immunodeficiency Virus. Yasuhiro Koga, Masafumi Sasaki, Hiroki Yoshida, Masumi Oh-Tsu, Genki Kimura, and Kikuo Nomoto ..... 5609-5612 The Purified 14-Kilodalton Envelope Protein of Vaccinia Virus Produced in Esch- erichia coli Induces Virus Immunity in Animals. Chingfeng Lai, Shiaoching Gong, and Mariano Esteban...... 5631-5635

ERRA TA Role of a Viral Membrane Polypeptide in Strand-Specific Initiation of Poliovirus RNA Synthesis. Cristina Giachetti and Bert L. Semler ...... 5653 Discordant Expression of the Immediate-Early 1 and 2 Gene Regions of Human Cytomegalovirus at Early Times after Infection Involves Posttranscriptional Processing Events. Thomas Stamminger, Elke Puchtler, and Bernhard Fleckenstein...... 5655 Mechanism of Selective Translation of Vaccinia Virus mRNAs: Differential Role of Poly(A) and Initiation Factors in the Translation of Viral and Cellular mRNAs. R. Bablanian, S. K. Goswami, M. Esteban, A. K. Bannerjee, and W. C. Merrick...... 5654

Continued on following page Continuedfrom preceding page RETRACTION Functional and Nonfunctional Measles Virus Matrix Genes from Lethal Human Brain Infections. Isidro Ballart, Marion Huber, Anita Schmid, Roberto Cattaneo, and Martin A. Billeter...... 5656

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