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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 27, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021. Downloaded from ASSESSING POPULATION BASED SEROPOSITIVITY FOR ANTIBODIES AGAINST SARS COV2 IN AHMEDABAD CITY OF INDIA ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2020-044101 Article Type: Original research Date Submitted by the 27-Aug-2020 Author: Complete List of Authors: Prakash, Om; Ahmedabad Municipal Corporation Solanki, Bhavin; Ahmedabad Municipal Corporation, Health Department SHETH, JAY; AMC MET Medical College, Community Medicine Joshi, Bhavin; Ahmedabad Municipal Corporation Kadam, Mina; AMC MET Medical College, Department of Microbiology Vyas, Sheetal; AMC MET Medical College, Department of Community Medicine Shukla, Aparajita; Smt NHL Municipal Medical College, Department of Community Medicine Tiwari, Hemant; Smt NHL Municipal Medical College, Department of Community Medicine Rathod, Sanjay; AMC MET Medical College, Department of Microbiology Rajput, Anil; AMC MET Medical College, Department of Microbiology http://bmjopen.bmj.com/ Trivedi, Toral; AMC MET Medical College, Department of Microbiology Ramanuj, Vaibhav; Smt NHL Municipal Medical College, Department of Community Medicine Solanki, Anand; AMC MET Medical College, Department of Community Medicine Keywords: COVID-19, IMMUNOLOGY, VIROLOGY on September 27, 2021 by guest. Protected copyright. For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 43 BMJ Open 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021. Downloaded from 5 6 7 8 9 I, the Submitting Author has the right to grant and does grant on behalf of all authors of the Work (as defined 10 in the below author licence), an exclusive licence and/or a non-exclusive licence for contributions from authors 11 who are: i) UK Crown employees; ii) where BMJ has agreed a CC-BY licence shall apply, and/or iii) in accordance 12 with the terms applicable for US Federal Government officers or employees acting as part of their official 13 duties; on a worldwide, perpetual, irrevocable, royalty-free basis to BMJ Publishing Group Ltd (“BMJ”) its 14 licensees and where the relevant Journal is co-owned by BMJ to the co-owners of the Journal, to publish the 15 Work in this journal and any other BMJ products and to exploit all rights, as set out in our licence. 16 17 The Submitting Author accepts and understands that any supply made under these terms is made by BMJ to 18 the Submitting Author Forunless you peer are acting as review an employee on behalf only of your employer or a postgraduate 19 student of an affiliated institution which is paying any applicable article publishing charge (“APC”) for Open 20 Access articles. Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 37 http://bmjopen.bmj.com/ 38 39 40 41 42 43 44 45 on September 27, 2021 by guest. Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 43 BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021. Downloaded from 1 2 3 4 Title: ASSESSING POPULATION BASED SEROPOSITIVITY FOR 5 6 7 ANTIBODIES AGAINST SARS COV2 IN AHMEDABAD CITY OF INDIA 8 9 10 11 Authors: 12 13 1 14 Dr. Omprakash, MBBS 15 Deputy Municipal Commissioner (Health), AMC. 16 [email protected] peer review only 17 18 2Dr. Bhavin Solanki, MD 19 In, charge Medical Officer of Health, AMC. 20 [email protected] 21 22 3 23 Dr. Jay K. Sheth, MD 24 Associate Professor, Community Medicine 25 [email protected] 26 27 4Dr. Bhavin Joshi, MD 28 Additional Medical Officer of Health, AMC 29 30 [email protected] 31 32 5Dr Meena Kadam, MD 33 Professor & Head, Microbiology Department http://bmjopen.bmj.com/ 34 [email protected] 35 36 6 37 Dr Sheetal Vyas, MD 38 Professor & Head, Community Medicine Department 39 [email protected] 40 41 7Dr Aparajita Shukla, MD on September 27, 2021 by guest. Protected copyright. 42 Professor & Head, Community Medicine Department 43 [email protected] 44 45 8 46 Dr Hemant Tiwari, Ph.D. 47 Assistant Professor cum statistician, Community Medicine Department 48 [email protected] 49 50 9Dr Sanjay Rathod, MD 51 Associate Professor, Microbiology Department 52 53 [email protected] 54 55 10Dr Anil Rajput, MD 56 Associate Professor, Microbiology Department 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 43 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021. Downloaded from 1 2 3 [email protected] 4 5 11 6 Dr Toral Trivedi, MD 7 Assistant Professor, Microbiology Department 8 [email protected] 9 10 12Dr Vaibhav Ramanuj, MD 11 Assistant Professor cum epidemiologist, Community Medicine Department. 12 [email protected] 13 14 15 13Dr Anand Solanki, MD 16 Assistant Professor Forcum epidemiologist, peer Community review Medicine only Department. 17 [email protected] 18 19 Author no 3, 5, 6, 9, 10, 11, 13 from AMCMET Medical College, Ahmedabad 20 Author no 7, 8, 12 from NHL Medical College, Ahmedabad 21 22 23 24 Corresponding author 25 26 Dr. Jay K. Sheth, MD 27 Associate Professor 28 Department of Community Medicine 29 AMC MET Medical College, Maninagar, Ahmedabad, Gujarat, INDIA 30 Email: [email protected] 31 Contact: +91-9427952244 32 33 http://bmjopen.bmj.com/ 34 Word Count 35 Abstract: 299 36 37 Article: 4370 38 39 40 41 on September 27, 2021 by guest. Protected copyright. 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 43 BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021. Downloaded from 1 2 3 4 Title: ASSESSING POPULATION BASED SEROPOSITIVITY FOR 5 6 7 ANTIBODIES AGAINST SARS COV2 IN AHMEDABAD CITY OF INDIA 8 9 10 11 ABSTRACT 12 13 Objectives: To study the percentage sero-positivity for SARS-CoV2 to understand the pandemic 14 15 16 status and predict theFor future situationspeer in Ahmedabad review only 17 18 19 20 Study Design: Cross Sectional study 21 22 23 Settings: Field area of Ahmedabad Municipal Corporation 24 25 Methods: A large scale sero-surveillance with more than 30,000 samples was carried out in the 26 27 Ahmedabad, Gujarat, India. Enrolled participants included general population including HCWs 28 29 from 75 Urban Primary Health Centers (UPHCs) across 48 wards and 7 zones of the city. Study 30 31 32 included various group of people irrespective of age, sex, acute/past covid19 infection. The 33 http://bmjopen.bmj.com/ 34 health department had collected the data using a simple brief format with minimum basic 35 36 primary demographic information. We analyzed the data, calculated seroprevalence and tried to 37 38 39 correlate seropositivity with various factors for valid and precise predictions on the herd 40 41 immunity status of the population. on September 27, 2021 by guest. Protected copyright. 42 43 44 45 46 Results: With seropositivity between 15%-20% for various age groups, the crude seropositivity 47 48 is 17·61%. The difference in seropositivity for both sex groups is not significant. The sero- 49 50 positivity is significantly lower(13·64%) for Health Care Workers (HCW) as compared to non- 51 52 Health Care Workers (18·71%). Week wise seropositivity shows increasing trend with time. 53 54 55 Zone with maximum initial cases have high positivity as compared to other zones. UPHCs with 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 5 of 43 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-044101 on 5 January 2021.
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