Endocrinology Research: & Hormones

Assay Kits Item No. Product Name Summary

IC (50% B/B ) of 240 pg/ml and an IC (defined as 80% 500520 EIA Kit 50 0 80 B/B0) of 70 pg/ml Limit of detection: 80% B/B : ~19 pg/ml 582251 EIA Kit 0 Sensitivity: 50% B/B0: ~129 pg/ml

Limit of detection: 80% B/B0: 4 pg/ml (4°C for 18 hours) 582281 EIA Kit 14 pg/ml (RT for 2 hours) • Sensitivity: 50% B/B0: 33 pg/ml (4°C for 18 hours), 95 pg/ml (RT for 2 hours) Follicle-Stimulating 500710 Measure within the range of 0.6 mIU/ml to 100 mIU/ml Hormone EIA Kit Growth Hormone (rat) Limit of detection: 80% B/B : 1 ng/ml 589601 0 EIA Kit Sensitivity: 50% B/B0: 3.6 ng/ml Luteinizing Hormone 500720 Measure within the range of 0.5 mIU/ml to 200 mIU/ml EIA Kit Limit of detection: 80% B/B : 10 pg/ml 582601 Progesterone EIA Kit 0 Sensitivity: 50% B/B0: 70 pg/ml (human) 500730 Measure within the range of 0.12 ng/ml to 100 ng/ml EIA Kit Limit of detection: 80% B/B : 0.9 ng/ml 589701 Prolactin (rat) EIA Kit 0 Sensitivity: 50% B/B0: 2.8 ng/ml Limit of detection: 80% B/B : 6 pg/ml 582701 EIA Kit 0 Sensitivity: 50% B/B0: 32 pg/ml Thyroid-Stimulating 500740 Measure within the range of 0.2 mIU/L to 20 mIU/L Hormone EIA Kit To view Cayman’s entire line

of Endocrinology products, Research Chemicals

request a copy of the Item No. Product Name Summary Endocrinology catalog A produced from the metabolism of the isoflavonoid by human intestinal 13184 (±)- microflora (EC50 = 200 and 74 nM for human ERα and ERβ, respectively)

A weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively; demonstrates higher ER 10010172 (R)-Equol agonist activity at ERα compared to ERβ (EC50 = 66 and 330 nM, respectively) agonist activity of this naturally occurring enantiomer (EC = 85 and 65 nM for human ERα and ERβ, 10010173 (S)-Equol 50 respectively) is similar to that of but exceeds that of daidzein 2,3-bis

10008842 (4-Hydroxyphenyl) An ERβ selective agonist (EC50 = 0.85 nM) Propionitrile

Selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (K = 4.2 μM), and AKR1C4 (K = 18.2 μM); 3-bromo-5-phenyl i i 13574 potently inhibits the metabolism of progesterone by bovine Salicylic Acid aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM) 5-bromo-3-pheny Selectively inhibits AKR1C1 (K = 140 nM) over AKR1C2 (K = 1.97 13379 i i Salicylic Acid µM) and AKR1C3 (Ki = 21 µM) A major metabolite produced from testosterone by the actions 6β-hydroxy Testosterone 10008519 of CYP3A4 and CYP3A5, accounting for 75-80% of all (DEA Schedule III) metabolites formed from testosterone 11α-hydroxy 10008647 Testosterone (DEA A CYP3A metabolite of testosterone Schedule III)

See reverse side for continued list

for full information on these products and more visit caymanchem.com Research Chemicals continued Item No. Product Name Summary

10010003 6α- A synthetic analog of testosterone enanthate

10010004 6β-Testosterone Enanthate A synthetic analog of testosterone enanthate

6-keto Testosterone 10010002 Enanthate A synthetic analog of testosterone enanthate As potent as, estradiol in most assays, with a longer half-life and a relative binding affinity to sex 10006876 hormone binding globulin of 0.2 compared to estradiol which has a relative binding affinity of 100

10006315 Estradiol The major estrogen synthesized from testosterone and secreted by the premenopausal ovary

An estradiol analog which contains a benzyl ester at the C-3 position and binds to the human and 10006487 murine estrogen receptor α, and chicken ER with IC50 values in the range of 22-28 nM A metabolite of estradiol and a major estrogen produced in the later stages of pregnancy that may 10006484 Estriol serve as a direct marker of fetal adrenal gland activity Synthesized from by the aromatase enzyme system in the ovaries and placenta, 10006485 and is also synthesized from estradiol by 17-hydroxy dehydrogenase in the liver A synthetic analog of estradiol used commonly as an oral contraceptive, often in combination with a 10006486 Ethynyl Estradiol progestin such as /levonorgestrel or desogestrel A potent estrogen receptor antagonist that works by down-regulating and degrading the estrogen receptor, 10011269 ERα Inhibits the proliferation of several cancer cell lines (IC ~ 0.28 μM) and promotes the degradation of 10012694 CAY10607 50 the Hsp90 client proteins Her-2 and receptor

10008933 G-1 A nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM

A synthetic steroid that acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone and follicle-stimulating hormone, thus reducing estrogen synthesis; also binds 10006488 to androgen (EC50 = 20 nM), progesterone (EC50 = 30 nM), and estrogen receptors in the human endometrial tissue A synthetic progesterone analog (i.e., a progestin) that prevents pregnancy by inhibiting ovulation and 10006318 Levonorgestrel by causing the cervical mucus to thicken

A potent progesterone receptor and glucocorticoid receptor antagonist (Ki ~ 1 nM); promotes efficient 10006317 Mifepristone binding of progesterone receptor to hormone response elements on DNA but prevents transcriptional activation of the receptor (IC50 = 0.6 nM) A synthetic progesterone analog (i.e., a progestin) used as an oral contraceptive, either alone (sold 10006319 Norgestrel under the trade name Ovrette®), or in combination with such as ethinyl estradiol

9000644 Progesterone 3-biotin An affinity probe that allows progesterone to be detected or immobilized using the biotin ligand

9000645 Progesterone 3-PEG11-biotin An affinity probe that allows progesterone to be detected or immobilized using the biotin ligand

An estrogen receptor α selective agonist with a 410-fold relative binding affinity for ERα (49%)versus 10008841 Propylpyrazole Triol ERβ (0.12%)

-11 15010 Prostaglandin F1α Acts as a priming pheromone for male Atlantic salmon with a threshold concentration of 10 M

10006320 A synthetic estrogen that is effective in hormone replacement therapy

10010001 Δ-6 Testosterone Enanthate A synthetic analog of testosterone enanthate

An estrogen-like compound used for the treatment of the symptoms associated with menopausal 10006321 transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis

10007452 Vinclozolin M2 An antagonist of the androgen receptor in rats (Ki = 9.7 µM)

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Cayman Chemical • Ann Arbor, MI 48108 • 800.364.9897 • caymanchem.com MAR2012