Conference Program November 24-26, 2014 Shaw Centre Ottawa, Ontario Genomics: the Power Genomics and the Environment Black and white the Presented by Genome & Promise and the Gairdner Foundation Powerandpromise.cvent.com/2014

#powerofgenomics @GenomeCanada @GairdnerAwards

Red - 0 C, 100 M, 100 Y, 0 K Blue - 100 C, 80 M, 0 Y, 30 K Table of contents

Welcome from the Governor General of Canada ...... 4 Welcome from the Prime Minister of Canada ...... 5 Genomics: Message from the Conference Co-Chairs ...... 6 the Agenda at a Glance ...... 8 Power About Genome Canada and The Gairdner Foundation ...... 12 the WIFI access: Floor Plan ...... 13 Promise Genome Canada and The Gairdner Foundation Day 1 – Monday, November 24 ...... 14 are pleased to offer conference delegates Day 2 – Tuesday, November 25 ...... 18 & complimentary Wireless Internet access. Day 3 – Wednesday, November 26 ...... 26 Step 1: search available wireless networks with your device Poster Presenters ...... 30 Step 2: connect to FREEMAN AV WIFI network Sponsors ...... 37 Step 3: open your preferred web browser About our Sponsors ...... 40 Step 4: select ‘Access code’ as method of payment Step 5: enter access code: GENOME (use all caps) Please note that the access code can only be entered into one device per delegate.

3 November 24-26, 2014 am delighted to extend my warmest greetings to treatment, Canada recognizes that genomics is a powerful am pleased to send greetings to everyone gathered for Genomics: the Power Ieveryone attending Genomics: The Power and the tool for innovation, environmental protection, economic Iand the Promise, presented by the Gairdner Foundation and Genome Canada. Promise – hosted by Genome Canada and the Gairdner growth, and social benefi t. Humanity is facing a great many challenges, including rapid population Foundation. I welcome all the conference delegates to This conference gathers the visionaries who are growth, threats to food security, a growing demand for energy, and stress on our beautiful Nation’s Capital. leading the genomics revolution in Canada and beyond, our natural resources. Innovative solutions are needed in order for us to cope. Canada is a fi tting place to explore the theme of this to share the newest science in such fi elds as epigenetics, With our strength in cutting-edge sciences and technology—and, in particular, conference, “Genomics and the Environment,” given our food security, and oil spill clean-up. Our Government genomics—Canada is among global leaders in generating new ideas and country’s expertise in genomics and the strong connec- supports the objectives of this conference and we look innovative approaches to addressing such pressing issues. tion that Canadians have with our natural environment. forward to the results of your deliberations. This unique event, under the banner of Genomics and the Environment, Through sustained investments by our Government, Canada has a strong record of scientifi c achievement. showcases recent discoveries in the fi eld as well as the great minds behind Canada has built a formidable research capacity in ge- As this event will attest, the future looks just as bright. them who are translating ideas into practical applications that produce social nomics – a fi eld of largely untapped power and potential. On behalf of the Government of Canada, please accept and economic benefi ts for all. Canada’s natural environment – our beautiful lakes my best wishes for a thought-provoking and productive In the spirit of discovery that has inspired Canadians for nearly 150 years, and rivers, abundant forests, and majestic mountains – is conference. I wish you an outstanding event. part of what defi nes us as Canadians. Through Genome Sincerely, Canada and the Canadian Institutes of Health Research (CIHR), our Government is seizing the opportunity to use genomics to protect and leverage our natural assets, as well as to improve health outcomes for Canadians. David Johnston From the ground-breaking use of genomics in sustain- November 2014 able resource extraction, to improvements in agriculture The Rt. Hon. Stephen Harper, P.C, M.P. and fi sheries, to breakthroughs in disease diagnosis and Prime Minister of Canada

4 5 CANARIE helps Canadians harness the power Message from the Conference Co-Chairs and the promise of genomics by advancing our knowledge and innovation infrastructure. e are delighted to welcome you to Genomics: Research conducted at the frontier of this moderators and delegates. We trust you will fi nd Wthe Power and the Promise. This event builds intersection has produced an explosion of innovation this conference to be rewarding, thought-provoking on the success of our 2012 conference by the same in health, environmental impact mitigation and and truly inspiring as we explore the power and name and is the second time our two organizations sustainable resource extraction. Genomics has promise of genomics. partner to convene those who are among the world’s transformed disease prediction, diagnosis and best and brightest in this cutting-edge fi eld of treatment; has helped create more sustainable Sincerely, science and technology. energy sources such as biofuels; has revolutionized Since the fi rst rough draft of the human genome livestock breeding and dairy production; has was mapped in 2000, researchers in Canada and developed biological tools to clean up oil spills Pierre Meulien National Research and the world over are beginning to understand the and remediate tailings ponds; and, has improved Education Backbone Network enormous range of complexity inherent in the breeding and management practices to make forests interplay between genes and the environment. and crucial crops such as wheat less susceptible to Pierre Meulien, PhD John H. Dirks, CM, MD, FRCP, FRSC From the study of epigenetics, the microbiome pests and climate change. President & CEO President & Scientifi c Director Research Software and the infl uence of environmental factors on Given these remarkable advances, we felt the Genome Canada The Gairdner Foundation human health to measuring the impact of climate time was ripe to bring together the experts at the Cloud Resources change on our forests, the more we have learned forefront of these discoveries across a wide spectrum for Startups about the biological blueprints of living organisms, of sectors, and provide a forum for exchange of the more we have revealed about how we affect our ideas and insights. We are delighted to host such Identity and Access environment and how our environment affects us. a distinguished roster of speakers, panelists, Management Solutions John H. Dirks

6 7 Agenda at a glance

Monday, November 24, 2014 Tuesday, November 25, 2014 2:30 pm - 3:00 pm Translating personalized genomic medicine: 10:30 am - 11:00 am Genomics, animal models and emerging 11:00 am Registration Opens (Registration will evidence, values and health policy SESSION 2 - ENVIRONMENTAL IMPACTS ON HUMAN HEALTH diseases: relevance to One Health remain open throughout conference) Yvonne Bombard and food security 7:30 am - 8:30 am Continental Breakfast John Harding 1:00 pm - 1:30 pm Welcome and Introduction 3:00 pm - 3:30 pm HEALTH BREAK and POSTER VIEWING 8:30 am - 9:00 am The human microbiome: a new frontier 11:00 am - 12:00 pm Panel Discussion 3:30 pm - 4:00 pm The opportunities and implications that might just affect everything Moderator: Ivan Semeniuk SESSION 1 - GENOMIC MEDICINE: THE HUMAN GENOME of personal genome sequencing George Weinstock PROJECT AND WHAT IT MEANS FOR PERSONALIZED Brad Popovich 12:00 pm - 1:30 pm LUNCH and POSTER SESSION MEDICINE AND HEALTH CARE Alex Dickinson 9:00 am - 9:30 am Epigenetics, epigenomics and cancer Andrew Feinberg 1:30 pm - 2:00 pm Bringing genomic medicine into focus 4:00 pm - 5:00 pm Panel Discussion SESSION 3 - ADAPTATION TO ENVIRONMENTAL FACTORS Eric Green Moderator: Catherine Zahn 9:30 am - 10:00 am Epigenomics of psychiatric disease IN THE RENEWABLE NATURAL RESOURCE AND Art Petronis AGRICULTURAL SECTORS 2:00 pm - 2:30 pm Neurogenomics 5:00 pm - 6:30 pm POSTER SESSION and RECEPTION Guy Rouleau 10:00 am - 10:30 am HEALTH BREAK and POSTER VIEWING 1:30 pm - 2:00 pm Adaptation to environmental challenges, an Arctic perspective Louis Fortier

8 9 Agenda at a glance Conference Steering Committee Co-Chairs: Pierre Meulien, Genome Canada John Dirks, Gairdner Foundation 2:00 pm - 2:30 pm Planetary biodiversity - agents of change 6:30 pm - 9:30 pm RECEPTION and GALA DINNER 9:30 am - 10:00 am Microbial metagenomics of oil sands Paul Hebert tailing ponds: small bugs, big data Members: Julia Foght Hélène Meilleur, Director of Events and 2:30 pm - 3:00 pm Crop genomics Wednesday, November 26, 2014 Sponsorships, Genome Canada, and Chair Doane Chilcoat 10:00 am - 10:30 am HEALTH BREAK and POSTER VIEWING of Conference Secretariat SESSION 4 - GENOMIC SOLUTIONS FOR ENVIRONMENTAL Karl Tibelius, Vice-President, Genomics 3:00 pm - 3:30 pm HEALTH BREAK and POSTER VIEWING AND OTHER CHALLENGES IN CANADA’S NON-RENEWABLE 10:30 am - 11:00 am Microbes, metagenomics and mining: Programs, Genome Canada RESOURCE SECTORS enhancing sustainability 3:30 pm - 4:00 pm Some like it hot: Population variation Lesley Warren Cindy Bell, Executive Vice-President, as a tool for climate change adaptation 7:30 am - 8:30 am Continental Breakfast Corporate Development, Genome Canada in forestry 11:00 am - 12:00 pm Panel Discussion Andrea Matyas, Director of Sally Aitken 8:30 am - 9:00 am Where angels fear to tread: reconciling Moderator: James Baxter Communications, Genome Canada natural resource development with Sommer Ellis, Director of Communications, 4:00 pm - 5:00 pm Panel Discussion indigenous wisdom and ecological principles 12:00 pm - 12:30 pm Perspective on the conference The Gairdner Foundation Moderator: L. Ian MacDonald David Wheeler Gerardo Jimenez-Sanchez The Co-Chairs would like to thank all the members of the respective sub-committees 5:00 pm - 6:30 pm POSTER SESSION and RECEPTION 9:00 am - 9:30 am Harnessing metagenomics in oil-spill cleanup: 12:30 pm - 12:40 pm Closing Remarks including the Conference Secretariat, Program lessons from the Deepwater Horizon spill Pierre Meulien Committee, Poster Session Committee, and Terry Hazen John Dirks Communications & Outreach Committee. A special thanks to Helina Tadesse and Valérie Meilleur for their considerable contributions. 10 11 About Genome Canada The Gairdner Foundation LEVEL & NIVEAU 2 Confederation Ramp - Rampe de Confédération

Genome Canada is a not-for-profi t organization that POSTER acts as a catalyst for developing and applying genomics and DISPLAY AREA genomic-based technologies, to create economic and social Black and white REGISTRATION benefi ts for Canadians. Genome Canada connects ideas and people across public and private sectors to fi nd new uses for GRDI CONNECTIONS

genomics, invests in large-scale science and technology to fuel LOUNGE Coat Room innovation, and translates discoveries into applications, new Vestiaire technologies, societal impacts and solutions across key sectors The Gairdner Foundation was created in 1957 SPEAKER READY/ of national importance, including health, agriculture, forestry, to recognize and reward the achievements of medical MEDIA ROOM Business Centre fi sheries & aquaculture, energy, mining, and the environment. researchers whose work contributes signifi cantly to improving Centre d`affaires the quality of human life. Since the fi rst awards were made in 1959, the Gairdner Awards have become Canada’s foremost international award. They hold up the pinnacle of CONFERENCE ROOM achievement as a mirror to Canadians, and in so doing, play a role in helping Canada achieve its goals of excellence.

Red - 0 C, 100 M, 100 Y, 0 K Blue - 100 C, 80 M, 0 Y, 30 K

55 Promenade Du Colonel By Drive • Ottawa, Ontario K1N 9J2 12 13 Day 1 • Monday, November 24

11:00 am Eric Green Over the last 25 years, Guy Rouleau and his team have focused on technologies in clinical care. Her research focuses on assessing the Registration Opens Director identifying the genes causing several neurological and psychiatric health outcomes and ethical and policy implications of integrating National Human Genome Research Institute diseases, including autism, amyotrophic lateral sclerosis, hereditary personalized genomic tests and technologies into health care. 1:00 – 1:30 pm Bethesda, MD, USA neuropathies, epilepsy and schizophrenia, as well as providing a Welcome & Introduction better understanding of the molecular mechanisms that lead to Eric Green is the Director of the National Human Genome these disease symptoms. Among Dr. Rouleau’s main achievements 3:00 – 3:30 pm Master of Ceremonies – Jay Ingram, Canadian author Research Institute (NHGRI) at the U.S. National Institutes of Health. are his contribution to the identifi cation of over 20 disease-causing Health Break and Poster Viewing and broadcaster For the past 25 years, he has been at the forefront of efforts to genes and his discovery of new mutational mechanisms. map, sequence, and understand the human genome, including Pierre Meulien – President and CEO, Genome Canada signifi cant start-to-fi nish involvement in the Human Genome 3:30 – 4:00 pm Project. He is responsible for providing overall leadership of 2:30 – 3:00 pm The opportunities and implications of personal John Dirks – President and Scientifi c Director, NHGRI’s research portfolio and other initiatives. Translating personalized genomic medicine: evidence, genome sequencing The Gairdner Foundation values and health policy Brad Popovich 2:00 – 2:30 pm Yvonne Bombard Professor SESSION 1 - GENOMIC MEDICINE: THE HUMAN GENOME Neurogenomics Assistant Professor Chief Scientifi c Offi cer PROJECT AND WHAT IT MEANS FOR PERSONALIZED Genome British Columbia MEDICINE AND HEALTH CARE Guy Rouleau Vancouver, BC, Canada Director Li Ka Shing Knowledge Institute 1:30 – 2:00 pm Montreal Neurological Institute and Hospital Toronto, ON, Canada Brad Popovich was one of the fi rst genetic counselors to Bringing Genomic Medicine into Focus McGill University immigrate to Canada in 1978. After completing his graduate and Montreal, QC, Canada Yvonne Bombard is an interdisciplinary genomics and health services postdoctoral training, Brad became the founding director of the researcher specializing in the assessment and translation of genomic San Diego Children’s Hospital DNA Diagnostic Laboratory in

14 15 Day 1 • Monday, November 24

1989 and was responsible for the translation of several new genetic Moderator tools will focus on food safety frameworks and the implementation research fi ndings into clinical practice. He was also a pioneer in the Catherine Zahn of a life-cycle approach to the regulation of health products, forensic use of DNA while in San Diego, and his laboratory was the President and CEO including pharmaceuticals, biologics, and medical devices. BE PART OF THE THINKING fi rst in the US to offer solely DNA-based paternity testing. Centre for Addiction and Mental Health Mr. Lee has lectured extensively on intellectual property law and pharmaceuticals law both nationally and internationally. Alex Dickinson Catherine Zahn is President and Chief Executive Offi cer of the Senior Vice-President Centre for Addiction and Mental Health, Canada’s leading mental Additional panelist Strategic Initiatives health hospital. She is a Fellow of the Royal College of Physicians Jim Ghadbane Illumina and Surgeons of Canada and a Professor at the University President and CEO San Diego, CA, USA of Toronto’s Faculty of Medicine. Dr. Zahn is internationally CANARIE recognized for her contributions to education and standards of Alex Dickinson is Illumina’s senior vice president of strategic practice in neurology. She is a champion for the integration of Jim Ghadbane is President and CEO of CANARIE – a vital initiatives. His group’s responsibilities include nation-scale psychiatry and neuroscience, and for steering mental illness into component of Canada’s digital infrastructure supporting population sequencing projects and the development of software the mainstream of medicine and the public spotlight. research, education and innovation. He is responsible for the for new sequencing applications. Previously, Dr. Dickinson ongoing of the advanced research and education was CEO of Helixis, a molecular diagnostic startup he co-founded Additional panelist network; technology innovation and the development of with Nobel Laureate David Baltimore. The company was acquired David K. Lee research software tools, and stimulating innovation and by Illumina in 2010. Director, Offi ce of Legislative and Regulatory Modernization commercialization in Canada’s ICT sector. Health Canada MAKING MEDICINE FOR THE MASSES

4:00 – 5:00 pm David K. Lee is the Director of the Offi ce of Legislative and 5:00 – 6:30 pm CONCORDIA.CA Panel Discussion on Session 1 topic Regulatory Modernization, Health Canada, whose mandate is to Poster Session and Reception CENTRE FOR APPLIED SYNTHETIC BIOLOGY Panelists include above-noted speakers as well as David Lee and modernize the Canadian Food and Drugs Act and corresponding Jim Ghadbane (see bios below). regulatory frameworks. The modernization of these regulatory

16 17 Day 2 • Tuesday, November 25

SESSION 2 - ENVIRONMENTAL IMPACTS ON HUMAN HEALTH and therapeutic approaches to promote health as well as treat Arturas Petronis John Harding infectious diseases and other dire medical conditions. Professor Professor 7:30 am - 8:30 am Centre for Addiction and Mental Health (CAMH) Western College of Veterinary Medicine Continental Breakfast University of Toronto University of Saskatchewan 9:00 – 9:30 am Toronto, ON, Canada Saskatoon, SK, Canada

8:30 – 9:00 am Epigenetics, Epigenomics and Cancer Arturas Petronis has been a faculty member at the Centre John Harding has served the Canadian swine industry for The human microbiome: a new frontier that might just for Addiction and Mental Health, and University of Toronto over 25 years, both in the private sector and in academia. affect everything Andrew Feinberg since 1997. Currently, he is Professor and Head of the Krembil He is presently a Professor in Swine Production Medicine at Director Family Epigenetics Laboratory. He is also Tapscott Chair for the Western College of Veterinary Medicine, University of George Weinstock Center for Epigenetics Schizophrenia Studies at the University of Toronto. His research Saskatchewan. His research activities focus on emerging and Associate Director and Professor Johns Hopkins University School of Medicine is dedicated to the elucidation of the role of epigenetic factors in re-emerging diseases of economic signifi cance to the Microbial Genomics Baltimore, MD, USA complex non-Mendelian diseases such as schizophrenia, diabetes, Canadian swine industry, including Brachyspira colitis, The Jackson Laboratory for Genomic Medicine and infl ammatory bowel disease. Dr. Petronis has published over Periweaning Failure-to-Thrive syndrome, reproductive PRRS Farmington, CT, USA Andrew Feinberg is Director of the Center for Epigenetics in the 100 papers and book chapters. and porcine circovirus. Institute for Basic Biomedical Sciences at Johns Hopkins. He holds George Weinstock, a pioneer in the genomic analysis of the an Adjunct Professorship at the Karolinska Institute in Sweden and microbiome, joined The Jackson Laboratory in September, is a Presidential Scholar at Harvard’s Dana Farber Cancer Institute. 10:00 – 10:30 am 11:00 am – 12:00 pm 2013 as professor and associate director for Microbial Genomics. Health Break and Poster Viewing Panel Discussion on Session 2 topic As a scientist dedicated to exploring how the microbiome Panelists include above-noted speakers as well as interacts with the host genotype to infl uence health and disease, 9:30 –10:00 am Robert Cushman and Roman Szumski (see bios below). Dr. Weinstock’s ultimate goal is to elucidate genomic mechanisms Epigenomics of Psychiatric Disease 10:30 – 11:00 am that could one day inform the development of new diagnostic Genomics, animal models and emerging diseases: relevance to “One Health” and food security

18 19 Day 2 • Tuesday, November 25

Moderator that as Ottawa’s Medical Offi cer of Health, where he pioneered SESSION 3 - ADAPTATION TO ENVIRONMENTAL Centres of Excellence that brings together specialists from Ivan Semeniuk comprehensive and controversial smoke free legislation in 2001. FACTORS IN THE RENEWABLE NATURAL RESOURCE 30 universities for the integrated study of the transformation of Science Reporter Dr. Cushman has worked as a primary care physician in a variety of AND AGRICULTURAL SECTORS the coastal Canadian Arctic. The Globe and Mail health-care settings. 1:30 – 2:00 pm Ivan Semeniuk reports on science and science policy for The Additional panelist Adaptation to environmental challenges, 2:00 – 2:30 pm Globe and Mail. With more than 20 years of experience in science Roman Szumski an Arctic perspective Planetary biodiversity – agents of change journalism, his previous roles include: US news editor for Nature, Vice-President of Life Sciences bureau chief for New Scientist magazine and producer and National Research Council Canada Louis Fortier Paul Hebert columnist with Discovery Channel, Canada. He is a contributing Scientifi c Director Director editor to Sky News magazine and he writes and hosts the award Roman Szumski, a Fellow of the Royal College of Physicians and ArcticNet Biodiversity Institute of Ontario winning astronomy television series, Cosmic Vistas. Surgeons of Canada, joined NRC in July 2005 as Vice-President Professor University of Guelph of Life Sciences. He is a recognized visionary leader and an Laval University Guelph, ON, Canada Additional panelist innovative manager with unique experience in building strategic Quebec, QC, Canada Robert Cushman public-private sector partnerships in the life sciences sector. Paul Hebert holds a Canada Research Chair in Molecular Senior Medical Advisor Dr. Szumski is also the Chair of the Genomics R&D Initiative, Louis Fortier holds the Canada Research Chair on the Response Biodiversity at the University of Guelph where he is Director Director General, Biologics and Therapies Directorate which coordinates federal science departments and agencies in of Arctic Marine Ecosystems to Climate Change at Université of the Biodiversity Institute of Ontario. He is a Fellow of the Health Canada the fi eld of genomics research. Laval. A specialist of zooplankton and fi sh, he has authored Royal Society of Canada and has honorary degrees from the and co-authored over 90 scientifi c papers on subjects varying Universities of Waterloo and Windsor. He is Scientifi c Director Robert Cushman is the Senior Medical Advisor at Health Canada from carbon fl uxes in the Arctic Ocean to policy in a changing of the International Barcode of Life Project, the largest research and the Director General of the Biologics and Genetic Therapies 12:00 – 1:30 pm Arctic. He is the Project Leader for the Canada Foundation for program ever undertaken in biodiversity science. His 400 Directorate. From 2005 to 2011, he served as the inaugural CEO Lunch and Poster Session Innovation-funded Canadian Research Icebreaker Amundsen, publications have received more than 25,000 citations. of the Champlain Local Health Integration Network, and prior to and the Scientifi c Director of ArcticNet, a Canadian Network of

20 21 Day 2 • Tuesday, November 25

2:30 – 3:00 pm Sally Aitken magazine of politics and public policy. He is the author of Crop genomics Professor fi ve books, including the 1984 national best-seller, Mulroney: Centre for Forest Conservation The Making of the Prime Minister. He is also the author of the Doane Chilcoat University of British Columbia critically acclaimed From Bourassa to Bourassa: Wilderness to Director Vancouver, BC, Canada Restoration. He served as chief speech writer to Prime Minister Applied Technology Systems (ATS) Mulroney from 1985-89 and later as head of public affairs at DuPont Pioneer Sally Aitken is a Professor in the Department of Forest and the Canadian Embassy in Washington from 1992-94. He was Johnston, IA, USA Conservation Sciences the University of British Columbia. Her Editor of Policy Options magazine from 2002-12. His political work is focused on the capacity of tree populations to adapt to or column appears on iPolitics and he is a frequent commentator Doane Chilcoat is the Director of Applied Technology Systems tolerate a range of climatic conditions, and implications of climate on CPAC and CTV. (ATS) at DuPont Pioneer, which includes high-throughput nucleic change for forest management. acid and protein analysis, genomics, protein production, antibody Additional panelist production, analytic chemistry, chemometrics, microscopy, plant André Lévesque transformation and greenhouses/controlled environments. ATS 4:00 – 5:00 pm Research Scientist includes more than 300 researchers at 6 sites on 3 continents. Panel Discussion on Session 3 topic Agriculture & Agri-Food Canada Panelists include above-noted speakers as well as André Lévesque and Pierre Lapointe (see bios below). André Lévesque is a Research Scientist with the Biodiversity group 3:00 – 3:30 pm of Agriculture & Agri-Food Canada, Central Experimental Farm, Health Break and Poster Viewing Moderator Ottawa, and is a study leader for the mycology/microbiology unit. L. Ian MacDonald He is adjunct professor in the Biology Department of Carleton Editor & Publisher University, Ottawa. His research is on molecular taxonomy, ecology 3:30 – 4:00 pm Policy Magazine and genomics of fungi, specializing on oomycetes and other Some like it hot: Population variation as a tool for zoosporic fungi. He published genomes for different species of the climate change adaptation in forestry L. Ian MacDonald is Editor and Publisher of Policy, Canada’s genus Pythium, generated the most comprehensive phylogenies

22 23 Day 2 • Tuesday, November 25

and DNA barcode databases for oomycetes, and has developed 6:30 – 9:30 pm Sharon Moalem several DNA-based assays for disease management, diagnostics Reception and Gala Dinner MD, PhD and molecular ecology. Master of Ceremonies: The Honourable Kelvin Ogilvie, Senator Sharon Moalem, MD, PhD - is an award- Additional panelist Address by The Honourable Ed Holder, Minister of State winning physician, scientist, inventor and Pierre Lapointe (Science and Technology) NYT-Bestselling author. He has been President and CEO researching rare genetic disorders for the last FP Innovations Ed Holder was fi rst elected to the House of Commons in 2008 20 years, working to fi nd novel treatments for and was re-elected in 2011. On March 19, 2014, Mr. Holder was people with rare or orphan diseases and has Pierre Lapointe is President and Chief Executive Offi cer of appointed Minister of State (Science and Technology). He has been awarded 21 patents worldwide for his FPInnovations since December, 2008. Under his leadership, been a member of several committees, including the Standing inventions in the fi eld of and human health. FPInnovations has positioned itself as Canada’s Forest Sector Committees on Industry, Science and Technology; International His scientifi c work has led to the discovery of a fi rst-in-class member Innovation Hub. FPInnovations’ scientifi c research has supported Trade; and Transport, Infrastructure and Communities. Mr. of a novel class of compounds directed against multi- the Forest Industry with landmark projects, from building the Holder is a Commander of the Order of St. John, a member resistant or ‘superbug’ microorganisms such as Methicillin-resistant world’s fi rst nanocrystalline cellulose demonstration plant (in of the Royal Canadian Legion and a recipient of the Queen Staphylococcus aureus (MRSA). Dr. Moalem has also cofounded two partnership with Domtar) to creating the most comprehensive CLT Elizabeth II Diamond Jubilee Medal and the Governor General’s biotechnology companies and has served as an associate editor for the (cross-laminated timber) handbook for the construction industry 125th Anniversary of the Confederation of Canada Medal for his Journal of Alzheimer’s Disease. as well as implementing the fi rst cellulose fi laments demonstration service to Canada. Dr. Moalem is also a New York Times and international bestselling plant in the world (in partnership with Kruger). author whose books have been translated into more than 35 languages. Keynote speech by Dr. Sharon Moalem, Award-winning physician, His latest book, Inheritance: How Our Genes Change Our Lives and scientist, inventor and New York Times bestselling author Our Lives Change Our Genes, was selected by Amazon as a Best 5:00 – 6:30 pm Book of the Year in the Category of Science for 2014. Poster Session and Reception The Scientifi c Signifi cance of the Rare: Why exceptional genetic conditions matter Copies of Dr. Moalem’s books can be purchased at Amazon.ca.

24 25 Day 3 • Wednesday, November 26

SESSION 4 - GENOMIC SOLUTIONS FOR ENVIRONMENTAL David has focused much of his advisory work in the fi elds of energy 9:30 – 10:00 am 10:30 – 11:00 am AND OTHER CHALLENGES IN CANADA’S NON-RENEWABLE conservation and renewable energy policy in Canada and the UK. Microbial metagenomics of oil sands tailing Microbes, metagenomics and mining: RESOURCE SECTORS ponds: small bugs, big data enhancing sustainability

7:30 am - 8:30 am 9:00 –9:30 am Julia Foght Lesley Warren Continental Breakfast Harnessing metagenomics in oil-spill cleanup: lessons Professor Professor from the Deepwater Horizon spill Department of Biological Sciences School of Geography and Earth Sciences 8:30 – 9:00 am University of Alberta McMaster University Where angels fear to tread: reconciling natural resource Terry Hazen Edmonton, AB, Canada Hamilton, ON, Canada development with indigenous wisdom and ecological Professor principles Department of Civil and Environmental Engineering Julia Foght is Professor of Microbiology at the University of Lesley Warren has established a pioneering, multidisciplinary Department of Microbiology Alberta. Her research has focused primarily on hydrocarbon research program identifying opportunities for the mining and David Wheeler Department of Earth and Planetary Sciences biodegradation, including bioremediation of oil spills and surveys energy resource sectors to monitor and manage their waste more President and Vice-Chancellor University of Tennessee of aerobic hydrocarbon-degrading microbes in Antarctica. More sustainably through novel identifi cation of the roles bacteria play Cape Breton University Knoxville, TN, USA recently her lab has been studying anaerobic processes in oil in key water quality processes. She has been identifi ed as an Sydney, NS, Canada sands tailings ponds. NSERC visionary for the Environmental Earth Sciences community. Terry Hazen is a fellow of the American Academy of Microbiology David Wheeler is President and Vice-Chancellor of Cape Breton and the American Association for the Advancement of Science. University. He is an internationally experienced academic and He has authored more than 295 scientifi c publications. His area of 10:00 – 10:30 am 11:00 am – 12:00 pm business person with more than two decades of senior executive specialty is environmental microbiology, especially as it relates to Health Break and Poster Viewing Panel discussion on Session 4 topic level involvement in change management and sustainable bioremediation, water quality, bioenergy and carbon cycling. Panelists include above-noted speakers as well as Javier Gracia- business practice, research and teaching. In the last fi ve years, Garza and Rick Lawrence (see bios below).

26 27 Day 3 • Wednesday, November 26

Moderator priorities; communicating the impact of NRCan’s work to 12:00 – 12:30 pm 12:30 – 12:40 pm James Baxter partners and stakeholders; creating an environment to Perspective on the conference Closing remarks Editor & Publisher sustain excellence in science; advancing science-policy iPolitics integration; furthering the integration and performance of the Gerardo Jimenez-Sanchez Pierre Meulien forest sector innovation system; and, supporting the delivery Program Director Genome Canada Over the past 25 years, James Baxter has been an award-winning of key programs including invasive alien species, climate change Genomics and Bioeconomy sportswriter, political journalist, bureau chief and editorial writer. and adaptation, and genomics. Harvard School of Public Health John Dirks A third-generation public affairs journalist, Mr. Baxter’s work Harvard University The Gairdner Foundation covering politics, fi rst in Ottawa and then in Alberta, earned him Additional panelist Boston, MA, USA a Nieman Fellowship at Harvard University in 2008, where his Rick Lawrence studies focused on international trade law and the future of the President Gerardo Jimenez-Sanchez is a certifi ed pediatrician, the media industry. Lawrence Consulting Ltd. Program Director of Genomics and Bioeconomy at Harvard School of Public Health, and Executive President of Global Additional panelist Rick Lawrence is the President of Lawrence Consulting Ltd., Biotech Consulting Group. He served as Chairman of Javier Gracia-Garza providing consulting services to the mining industry since Biotechnology at the Organization for Economic Co-operation Deputy Chief Scientist 1987. He is also an Adjunct Professor at the University of and Development (OECD) from 2007 to 2014, founding Director Natural Resources Canada British Columbia, where he teaches courses in mine feasibility of the National Institute of Genomic Medicine in Mexico, and and precious metal ore processing. Rick has been involved director of the Mexican Genomic Diversity Project. He chairs Javier Gracia-Garza is Deputy Chief Scientist of Natural in consulting, process development, research and education the Committee on Genomics and Bioeconomy at the Human Resources Canada (NRCan) and Director General, Science for nearly 40 years. Rick is a Professional Engineer in BC and a Genome Organization, and has served as a Council Member in Program Branch of the Canadian Forest Service at NRCan. Chartered Engineer in the UK. Biotechnology to the United Nations Secretary General. His responsibilities include: ensuring alignment of the CFS S&T portfolio to Government of Canada and departmental

28 29 Poster Presenters

PRESENTER PRESENTER PRESENTER PRESENTER NO. AFFILIATION TITLE NO. AFFILIATION TITLE LAST NAME FIRST NAME LAST NAME FIRST NAME

Comparative genomic studies of Transcriptomic analysis reveals host-specifi c Desulfosporosinus: functional diversity 5 Braden Laura University of Victoria feeding responses of the salmon louse, 1 Abu Laban Nidal University of Alberta in anaerobic hydrocarbon-impacted Lepeophtheirus salmonis. environments Value Addition Through Genomics Identifi cation of single nucleotide (VALGEN) use of scenario methods: polymorphism markers associated with 6 Dhaliwal Nicky (Amarpreet) University of British Columbia Envisioning possible futures for 2 Akanno Everestus University of Alberta heifer fertility and calving performance Canadian agricultural biotechnology using genome-wide association in beef commercialization cattle Transposon mediated gene trapping in Comparing apples to apples: A genome- 7 El-Rass Suzan University of Toronto zebrafi sh reveals a novel cardiovascular 3 Amyotte Beatrice University of Guelph wide association study of human sensory function for PDGFRA attributes in apple Commercialization of Molecular Diagnostics The 3-I framework: A framework for 8 Fanton-Aita Fiorella Université de Montréal in Canada: A Landscape Analysis and Case 4 Bashir Naazish University of Toronto developing public policies around Study pharmacogenomics testing in Canada.

30 31 Poster Presenters

PRESENTER PRESENTER PRESENTER PRESENTER NO. AFFILIATION TITLE NO. AFFILIATION TITLE LAST NAME FIRST NAME LAST NAME FIRST NAME

Characterization of the vaginal microbiome A high-throughput method for 9 Freitas Aline University of Saskatchewan in pregnancy 13 Hui Tony (Zhao Kun) University of British Columbia whole-genome single-cell methylation sequencing Degraded DNA and next generation Heterogeneity Analyses Using Genomics sequencing: low quality DNA affects 10 Graham Carly University of Regina 14 Lalonde Emilie University of Toronto and the Tumour Microenvironment Predict double digest Restriction Associated Prostate Cancer Recurrence DNA Sequencing (ddRADSeq)

Critical innate immune genomic responses Discovery of minor histocompatibility 15 Langlais David McGill University 11 Granados Diana Paola Université de Montréal antigens for leukemia immunotherapy conducted by IRF8 and IRF1 with a novel genoproteomics approach A fi nancial analysis of establishing poplar LRP1B and BRD2: New candidate plantations for carbon offsets using Alberta 16 Long Amanda University of Alberta genes in fetal metabolic programming and British Columbia’s afforestation 12 Houde Andrée-Anne Université de Sherbrooke of the newborn exposed to maternal protocols hyperglycemia

32 33 Poster Presenters

PRESENTER PRESENTER PRESENTER PRESENTER NO. AFFILIATION TITLE NO. AFFILIATION TITLE LAST NAME FIRST NAME LAST NAME FIRST NAME

Insights regarding the emergence of new Discovery of interspecifi c rust hybrids using 22 Pu Ting University of British Columbia 17 Marsh Kayla Trent University wheat leaf rust virulence types through genotyping-by-sequencing approach transcriptome analysis

Statement of principles on the return of Limited impact of phlebotomy technique 23 Sénécal Karine McGill University 18 Morrison Jaclyn University of British Columbia research results and incidental fi ndings on proteomic measures

IslandViewer and IslandPlot: fl exible identifi - Characterization of the Infectious cation, visualization, and characterization of Department of Fisheries and Hematopoietic Necrosis Virus (IHNV) carrier 19 Müller Anita 24 Shay Julie Simon Fraser University microbial genomic regions associated with Oceans Canada state in sockeye salmon (Oncorhynchus adaptations of environmental, medical, and nerka) industrial importance Comparative genomics of Vibrio metoecus Blood biomarkers of the late phase 20 Orata Fabini University of Alberta with its close relative Vibrio cholerae reveal 25 Singh Amrit University of British Columbia its pathogenic potential asthmatic response using RNA-Seq

3 Towards improved watershed monitoring Early use of GE LS methodology enhances 21 Peabody Michael Simon Fraser University through novel genetic tests 26 Stanley Dana University of Victoria decision support tool development for TIA biomarker test in Emergency Departments.

34 35 Poster Presenters Sponsors

DISCOVERERS SPONSORSHIP PRESENTER PRESENTER NO. AFFILIATION TITLE LAST NAME FIRST NAME

The role of DNA barcoding technology in 27 Ugochukwu Albert University of Saskatchewan fi sh species authentication

Genetic differentiation and population connectivity in Northwest Atlantic Van Memorial University of 28 Mallory populations of the sea scallop, Placopecten Wyngaarden Newfoundland magellanicus, using whole-genome scanning PIONEERS SPONSORSHIP Transcription factor motif discovery and 29 Viner Coby University of Toronto prediction in an expanded epigenetic alphabet

Major cellulolytic bacteria and fungi and 30 Wilhelm Roland University of British Columbia their carbohydrate active enzymes in temperate California forest soils

See poster abstracts in Genome, Volume 57, No. 7. available in your conference bag.

36 37 Sponsors

POSTER SESSIONS SPONSORSHIP IN-KIND SUPPORT

GALA TABLES SPONSORSHIP

Alberta Innovates Bio Solutions leads science and innovation to grow prosperity in Alberta’s agriculture, food and forestry sectors.

bio.albertainnovates.ca Funded by the Government of Alberta

38 39 About our Sponsors

Olympic gold medalists. Oscar winners. Satellite Designers. Concordia University has them all. Creative. Diverse. Concordia pushes boundaries by The University of Ottawa is the largest crossing disciplines. Acclaimed fi elds include aerospace, bilingual (English-French) university in the world. nanotechnology, journalism, psychology, genomics, Today’s Merck is a global healthcare leader working Located at the heart of Canada’s capital, we The Children’s Hospital of Eastern cinema, studio arts, fi nance and sustainable business. to help the world be well. Merck is known as MSD have ready access to the great institutions of our Ontario (CHEO), the pediatric hospital in outside the United States and Canada. Through country. Our advances in social sciences, health, Canada’s capital region, helps over 500,000 kids Bold, urban energy. 46,000 students in Montreal, our prescription medicines, vaccines, biologic science and the humanities make uOttawa a each year in Ontario, Quebec and Nunavut. It North America’s most exciting city. Leading research, therapies, and animal health products, we work with unique place to learn, grow and excel. is affi liated with the University of Ottawa and top teaching, engaged community — transformative customers and operate in more than 140 countries is home to globally-recognized clinicians and experiences through fl exible, friendly service. to deliver innovative health solutions. We also researchers tackling cancer with viruses, mental Celebrating 40 years in 2014, Concordia defi nes the demonstrate our commitment to increasing access illness, gene discovery, obesity and much more. next-generation university. to healthcare through far-reaching policies, programs and partnerships. For more information about our operations in Canada, visit www.merck.ca.

40 41 About our Sponsors

Founded in 1981 in Boston, Massachusetts, Genzyme CANARIE designs and delivers digital infrastructure, evolved from a tiny start-up to one of the world’s leading and drives its adoption for Canada’s research, education biotech companies, with nearly 10,000 employees and and innovation communities. Twelve provincial and operations in every region of the globe. Acquired by Sanofi territorial network partners, together with CANARIE, in 2011, Genzyme now benefi ts from the reach and resources collectively form Canada’s National Research and Education of one of the world’s largest pharmaceutical companies, with Network (NREN). This powerful digital infrastructure a shared commitment to improving the lives of patients. connects Canadians to national and global data, tools, The Canada Foundation for Innovation Genzyme has long been known for our expertise in the colleagues, and classrooms that fuel the engine of gives researchers the tools they need to think big and class of rare genetic diseases known as lysosomal storage innovation in today’s digital economy. innovate. By investing in state-of-the-art facilities and disorders (LSDs). LSDs remain the heart of our company equipment in Canada’s universities, colleges, research One million researchers, and students at nearly today, but we have also expanded our focus to other rare hospitals and non-profi t research institutions, the 2,000 Canadian institutions, including universities, colleges, diseases and multiple sclerosis. The University of Guelph is ranked as one of CFI is helping to attract and retain the world’s top research institutes, hospitals, and government laboratories Canada’s top comprehensive universities because of talent, to train the next generation of researchers, Driven by our commitment to patients, we strive to develop have access to the CANARIE Network. our commitment to student learning and innovative to support private-sector innovation and to create strong relationships with patient communities and listen research. We are dedicated to cultivating the essentials Established in 1993, CANARIE is a non-profi t corporation, high-quality jobs that strengthen the economy and to their perspectives so that we can truly understand their for our quality of life - water, food, environment, animal with the major investment in its programs and activities improve the quality of life for all Canadians. needs. These collaborations guide us as we continue to push and human health, community, commerce, culture and provided by the Government of Canada. the boundaries of medicine and technology to develop new and better therapies where none existed before. learning. The University community also shares a profound sense of social responsibility, an obligation to address global issues and a concern for international development.

42 43 About our Sponsors

The Peter Gilgan Centre for Research and Learning (PGCRL) is the new home for research and learning at The Hospital for Sick Children (SickKids). Located at the eastern gateway to Toronto’s Discovery district, this Illumina is a leading developer, manufacturer, and 750,000 square-foot facility houses 21 fl oors of leading-edge marketer of life science tools and integrated systems for research space and high-tech, innovative learning space. More large-scale analysis of genetic variation and function. than 2,000 scientists, trainees and child health research staff These systems are enabling studies that were not even Through the Genomics Research and work in the PGCRL, and many more members of the SickKids imaginable just a few years ago, and moving us closer Development Initiative (GRDI), federal science community use our learning concourse every day. to the realization of . With rapid department and agencies collaborate in the fi eld of The state-of-the-art laboratory and learning facilities are PwC Canada helps organizations and advances in technology taking place, it is mission- genomics research to address biological issues that are important to Canadians, focusing on the role of federal designed to enable and enhance new collaborations across individuals create the value they’re looking for. critical to offer solutions that are not only innovative, but Our 5,800 partners and staff in offi ces across the government research. The initiative delivers concerted, research disciplines with the end goal of fi nding new ways fl exible and scalable, with industry-leading support and country are committed to delivering quality in high-calibre genomics research to provide economic, social to improve child health. This new facility was designed to service. We strive to meet this challenge by placing a assurance, tax, consulting and deals services. PwC and environmental benefi ts for Canadians in important accommodate the most specialized research and learning high value on collaborative interactions, rapid delivery Canada is a member of the PwC network of fi rms areas such as health, food safety, sound management of needs. The different areas of research are refl ected in six of solutions, and meeting the needs of our customers. with more than 195,000 people in 157 countries. natural resources, a sustainable and competitive agriculture neighbourhoods of science that are connected through Find out more by visiting us at www.pwc.com/ca. sector, and environmental protection, with strong staircases and large, multi-level open interactive spaces to collaborations with university and private sectors. encourage interdisciplinary engagement.

44 45 About our Sponsors

The Hospital for Sick Children (SickKids) is Rx&D is the association of leading research-based recognized as one of the world’s foremost paediatric health-care pharmaceutical companies dedicated to improving the institutions and is Canada’s leading centre dedicated to advancing health of Canadians through the discovery and development children’s health through the integration of patient care, research Alberta Innovates Bio Solutions, is a board- of new medicines and vaccines. Our community represents and education. Founded in 1875 and affi liated with the University governed research corporation funded by the Government the men and women working for more than 50 member of Toronto, SickKids is one of Canada’s most research-intensive of Alberta. We work with partners to identify, coordinate companies which invest more than $1 billion in research CropLife Canada represents the Canadian hospitals and has generated discoveries that have helped and fund research projects to grow prosperity in Alberta’s and development each year to fuel Canada’s knowledge- manufacturers, developers and distributors of children globally. Its mission is to provide the best in complex agriculture, food and forest sectors. We provide leadership based economy, contributing over $3 billion to the Canadian pest control products and plants with novel traits. and specialized family-centred care; pioneer scientifi c and clinical and coordination for science and innovation in these sectors economy. Guided by our Code of Ethical Practices, our Although many aspects of the plant science advancements; share expertise; foster an academic environment that currently contribute more than $25 billion every year membership is committed to working in partnership with industry have evolved since the organization that nurtures health-care professionals; and champion an into the Alberta economy. AI Bio is an integral part of the governments, private payers, healthcare professionals and was fi rst established in 1952, the main purpose accessible, comprehensive and sustainable child health system. Alberta Innovates family, an alliance of organizations with stakeholders in a highly ethical manner. remains the same – to advance the collective SickKids is proud of its vision for Healthier Children. A Better a legislative mandate to further research and innovation in interests of the industry in Canada. World. For more information, please visit www.sickkids.ca. the province. We have strong relationships with research performers, private industry, producer organizations, funding agencies, our sister Alberta Innovates corporations, and the federal, provincial and municipal governments. We work with these partners to develop solutions to help solve industry challenges and inform government policy decisions. Visit www.bio.albertainnovates.ca.

46 47 About our Sponsors THE PETER GILGAN CENTRE FOR RESEARCH AND LEARNING

TRANSFORMATIVE IMPACT DISCOVERY

VISION COLLABORATION

INNOVATION GLOBAL Genome is one of the 16 NRC Research Press A rare commitment journals published by Canadian Science Publishing, which are distributed worldwide to over 175 countries. Established To discover and deliver transformative in 1959, this monthly journal publishes original research therapies for patients with rare and articles, reviews, mini-reviews, and commentaries. The areas special unmet medical needs, providing Come make a difference with us in Toronto of interest include general genetics, cytogenetics, molecular www.sickkids.ca/Research/index.html is independent, non-partisan and committed to genetics, evolutionary genetics, population genetics, iPolitics hope where there was none before. providing timely, relevant, insightful content to those whose developmental genetics, plant genetics, microbial genetics, professional or personal interests require that they stay on mammalian genetics, genomics, and other related areas. top of political developments in Ottawa and the provinces. The journal Editors are Dr. G. Scoles, Dr. M. Cristescu, and Working in a spirit of neutral inquiry, our daily news service will A history of innovation – Dr. A. Hilliker. Genome is proudly affi liated with the Canadian include coverage of the legislative, regulatory, political and a future of infinite possibilities Society for Molecular Biosciences, and is proud to support policy developments that matter most to businesspeople, Genomics: The Power & The Promise. Join us in celebrating a century of professionals, politicians, public servants, political activists Canadian innovation and contribution and the more politically-aware. www.ipolitics.ca to global health care advances. Visit www.canadapharma.org/100

www.genzyme.ca

48 49 Notes Notes

We help you achieve deal success, from concept to close— and beyond

www.pwc.com/ca/deals

© 2014 PricewaterhouseCoopers LLP, an Ontario limited liability partnership. All rights reserved. 3054-08-1114

50 51 2147-92 Deals Ad.indd 1 14-11-05 12:25 PM Black and white

Red - 0 C, 100 M, 100 Y, 0 K Blue - 100 C, 80 M, 0 Y, 30 K

Powerandpromise.cvent.com/2014 #powerofgenomics