A B C D Supplementa Figure 1. Ry Murine Neurod1 Is Dispensable for the Differentiation of Ngn3+ Pancreatic Endocrine Precursors

SUPPLEMENTARY DATA

Supplementary Figure 1. Murine Neurod1 is dispensable for the differentiation of Ngn3+ pancreatic endocrine precursors but is subsequently required for the late fetal expansion of Insulin and Glucagon+ cells. A: Representative IF images of fetal and new born pancreas sections. Scale Bar = 200um. B: Quantification of hormone expressing cells normalized to area of pancreas n=4-5 per genotype. C: IF expression analysis of indicated markers preformed on sections of E15 pancreata. Scale Bar = 50um. D: Quantification of the number of Ngn3+ cells normalized to area of pancreas . All error bars indicate standard deviation. Student T-test P value compares values of controls to those of indicated genoptype; *p< 0.02, **p< 0.001.

A Neurod1+/+ Neurod1-/- Neurod1+/+ Neurod1-/-

B 0.025 ** E17 0.020 0.015 * 0.010

0.005 cells / pancreas area pancreas cells /

% number hormone+number % 0.000 P0 S S G G S S G G N Ins+N Gcg+ N Ins+N Gcg+ I I C C I I C C T T G G T T G G U T T U T T W E17 W P0 7 M W U 0 M W U 1 7 7 M P 0 0 M E 1 1 7 P P 0 E E 1 P Insulin Glucagon Cpa1 DAPI E

C Neurod1+/+ Neurod1-/- D 0.15

0.10 E15

0.05 pancreas area pancreas

% number Ngn3+ / cells Ngn3+ number % 0.00 Ngn3 Cpa1 DAPI

Supplementary Figure 2 . Deletion o f murine Neurod1 in the Neurog3 endocrine lineage results in perinatal diabetes and lack of insulin+ and glucagon+ cells. A: Representative IF images of new born pancreas sections. Scale Bar = 200um. B: Quantification of hormone expressing cells normalized to area of pancreas n=4 per genotype. C: Blood glucose of P1 mice n=4-28 per genotype. All error bars indicate standard deviation. Student T-test P value compares values of controls to those of indicated genoptype; *p< 0.0005.

A Neurod1flox/flox Ngn3Cre Neurod1Δendo

Neurod1flox/flox Ngn3Cre

Neurod1Δendo P0 Neurod1+/+ Neurod1-/-

Insulin Glucagon Cpa1 DAPI

B * C * 0.025 600

0.020 500 *

) 400 0.015 * dL 300

0.010 (mg/ 200

0.005 Glucose Blood 100

cells / pancreas area pancreas cells / % number hormone+number % 0.000 0 Ins+ Gcg+

Supplementary Figu re 3. Nkx6-1expression is maintained in remaining Insulin+ cells. Representative IF images of new born pancreas (P0) sections. Scale Bar = 50um.

Neurod1+/+ Neurod1-/-

Insulin Nkx6-1 DAPI

Supplementary Figure 4. A: Schematic of the differentiation of HESC into HESC-beta cells. B: Design of CRISPR sgRNA for disruption of NEUROD1 in HESCs C: IF for NEUROD1 and INSULIN expression by D27 HESC-beta cells. Scale Bar = 50um. D: Normal karyotype of a NEUROD1mut/mut hESCs line.

©2019 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db19-0117/-/DC1 SUPPLEMENTARY DATA A Day 3 Day 12 Day 27 Definitive Endoderm Pancreatic Progenitor Endocrine Cluster

HESC-beta cells HESC Sox17+ PDX1+ (INSGFP+) MAFA+ Foxa2+ NKX6-1+ INS-GFP+

NEUROD1

B bHLH

sgRNA

Sequence PAM=GGG Clone Allele sgRNA=ACGCATGAAGGCTAACGCCC Protein Size Wild Type TTGAGACGCATGAAGGCTAACGCCCGGGAGCGGAAC 355

A2 Indel 1 TTGAGACGCATGAAGGCTAACG----GGAGCGGAAC 116 A2 Indel 2 TTGAGACGCATGAAGGCTAAC-CCCGGGAGCGGAAC 117

A10 Indel 1 TTGAGACGCATGAAGGCTAAC--CCGGGAGCGGAAC 132 A10 Indel 2 TT------CCCGGGAGCGGAAC 109

A12 Indel 1 TTGAGACGCATG-CGG-T-TC-CCCGGGAGCGGAAC 116 A12 Indel 2 TTGAGACGCATGAAGGCTAAC--CCGGGAGCGGAAC 132

A26 Indel 1 TT------C 118 A26 Indel 2 TTGAGACGCATGAAGGCTAAC--CCGGGAGCGGAAC 132

C D27

NEUROD1+/+ NEUROD1mut/mut

©2019 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db19-0117/-/DC1 SUPPLEMENTARY DATA Supplementary Figure 5. Impaired differentiation of NEURODmut/1 mut HESC derived pancreatic progenitors into insulin expressing cells. A: Expression of NEUROD1, INS, and GCG mRNA relative to D13 during the differentiation of pancreatic progenitors into insulin expressing cells determined by RT-qPCR analysis. B-C: IF of pancreatic endocrine markers C-PEPTIDE, Glucagon, and Chromogranin A at D18 of sc-Beta differentiation, Scale Bar = 20um.

NEUROD1 INS GCG Relative mRNARelative

13 15 17 20 27 13 15 17 20 27 13 15 17 20 27

B D18 scBeta

+/+

NEUROD1

mut

mut/ NEUROD1

C-PEP GCG C-PEP GCG DAPI

C D18 scBeta

+/+

NEUROD1

mut

mut/ NEUROD1

Supplementary F igure 6 . S orting IN SULIN-GFP+ c ells fr om D 27 H ESC-beta s tage NEUROD1 +/+ and NEUROD1mut/mut cells. A: FACS plots with gate (P4) used to sort INS GFP expressing cells from NEUROD1+/+ and NEUROD1mut/mut populations at day 27 of the HESC-beta cell differentiation protocol. Undifferentiated HESCs were used as a negative control. B: Quantification of the % of INS-GFP+ cells out of total NEUROD1+/+ and NEUROD1mut/mut populations at day 27 of the HESC-beta cell differentiation protocol.

A D27

NEUROD1+/+ NEUROD1mut/mut Negative Control APC

INS-GFP

B 50 p<0.005 NEUROD1+/+ NEUROD1mut/mut

40 GFP+

- 30

20 (% of total cells) total (%of INSULIN 10 0

©2019 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db19-0117/-/DC1 SUPPLEMENTARY DATA Supplementary Figure 7 . Mice and HESC require NEUROD1 for the expression of beta cell genes. A: Venn Diagram indicating overlap of differentially expressed genes in NEUROD1 deficient cells between D27 HESC-INS+ cells, E17 murine pancreatic endocrine cells and 12 week adult islet beta cells. B: Tables of Neurod1 dependent gene programs in common or unique to D27 HESC-INS+ cells, E17 murine pancreatic endocrine cells and 12 week adult islets.

©2019 American Diabetes Association. Published online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db19-0117/-/DC1 SUPPLEMENTARY DATA A Genes downregulated Genes upregulated in NEUROD1mut/mut cells in NEUROD1mut/mut cells

HESC HESC D27 INS-GFP+ Cells D27 INS-GFP+ Cells

2109 2417

139 50 29 91 146 54 491 26 9 Neurod1Δendo Neurod1Δbeta E17 endocrine 12 week islets 106 43 521 Neurod1Δendo Neurod1Δbeta E17 endocrine 12 week islets

B HESC- INS+ cells and mouse E17 endocrine cells and mouse 12 week islet beta cells

Islet Transcription Factors LMX1B CACNA1C, TRPM5, VIPR1, G6PC2, SNPH, SCGN, Beta Cell Functional Markers SYTL3, GPR142 ER stress + UPR JPH4, Proliferation RET, CDKL1 HESC-INS+ cells and mouse E17 endocrine cells only

Islet Transcription Factors MAFA, MYT1L, ZDBF2 Islet Hormones IAPP, SCT, GIP, GCG GPR119, SV2B, SYP, CAMK2B, SYT13, RAB39B, BICD1, Beta Cell Functional Markers RASGRF1, KIF5C, HIP1R, DENND2D, MICALCL, RAB9B, GPX3 ER stress + UPR HSPA13, JPH4, ESYT3 Proliferation CCND2, CDK5R2 HESC-INS+ cells and mouse 12 week islet beta cells only

Islet Transcription Factors NKX2-2, MLXIPL, Beta Cell Functional Markers CACNB1, STXBP1, CACNB3, SYT6, RPH3AL Beta Cell Immaturity or Dysfunction LDHA ER stress + UPR HSPA2, ERO1LB Proliferation CCNB2 HESC-INS+ cells only

Islet Transcription Factors NKX6-1, PAX6, INSM1, ISL1, RFX6 Beta Cell Functional Markers GCK, ABCC8, SLC30A8, GLP1R

Supplementary Ta ble 1: List of antibodies. Antibody Species Supplier dilution Cat# Sox17 Goat R&D Systems 1/100 AF1924 Foxa2 Rabbit Cell Signaling Technonogy 1/200 3143S PDX1 Goat R&D Systems 1/100 AF2419 NKX6-1 Mouse DSHB 1/300 F55A10 NEUROD1 Rabbit Cell Signaling Technonogy 1/5000 4373 MAFA Rabbit Abcam 1/200 AB26405 NEUROG-3 Rabbit Beta Cell Biology Consortium 1/500 AB2011 CHGA Rabbit Abcam 1/1000 AB15160 C-PEPTIDE Rat DSHB 1/400 GN-ID4 INSULIN Guinea Pig DAKO 1/1000 A0564 GCG Goat SANTA CRUZ 1/100 sc-7780 GCG Rabbit Dako 1/1000 A0565 Cpa-1 Goat R&D Systems 1/500 AF2765 KI67 Rabbit Abcam 1/500 AB16667 anti-goat IgG-555 Donkey Invitrogen 1/1000 A-31572 anti-goat IgG-647 Donkey Invitrogen 1/1000 A-21447 anti-rabbit IgG-488 Donkey Invitrogen 1/1000 A-212026 anti-rabbit IgG-555 Donkey Invitrogen 1/1000 A-31572 anti-rabbit IgG-647 Donkey Invitrogen 1/1000 A-31573 anti-rat IgG-488 Goat Invitrogen 1/1000 A-21434 anti-mouse IgG-488 Donkey Invitrogen 1/1000 A-21202 anti-mouse IgG-647 Donkey Invitrogen 1/1000 A-31571 anti-Guinea pig IgG-568 Goat Invitrogen 1/1000 A-11075

Supplemental Table 2: Gene expression changes in e17 Neurod1 deltaEndo vs. control cells

gene baseMean_all baseMean_Control baseMean_ND_KO foldChange log2FoldChange pval padj

Nnat 13111.8065 25342.62128 880.9917205 0.034763244 -4.846293484 1.2E-96 2.25E-92 G6pc2 3197.924335 5992.586655 403.2620149 0.067293481 -3.893389443 1.13E-60 1.06E-56 Npy 1330.013598 2423.994572 236.0326237 0.097373413 -3.360328285 2.96E-42 1.85E-38 Neurod1 1057.217685 1931.541859 182.8935105 0.094687832 -3.400677152 5.18E-22 2.43E-18 Tmem215 489.5017453 844.4339264 134.5695642 0.159360679 -2.649632392 5.93E-19 2.22E-15 Rnf130 3055.596642 4744.194595 1366.998689 0.288141361 -1.795151327 4.58E-18 1.43E-14 Gpr119 183.7011804 342.2307659 25.17159491 0.073551526 -3.765100925 3.32E-17 8.89E-14

Ush2a 170.5212952 320.4159314 20.6266589 0.064374636 -3.957363824 4.99E-17 1.17E-13

Nipal1 339.394884 590.4010671 88.3887009 0.149709589 -2.739761468 3.46E-16 7.21E-13

Slc2a5 567.3353574 941.9069527 192.7637621 0.204652659 -2.288750686 6.04E-16 1.13E-12

Adcy1 1046.371001 449.9541362 1642.787866 3.651011813 1.868296337 4.32E-14 7.37E-11

9330182L06Rik 268.1198138 461.99861 74.24101763 0.160695327 -2.63760012 4.13E-13 6.29E-10

Cntfr 246.0782326 432.7117203 59.44474486 0.137377247 -2.863785017 4.36E-13 6.29E-10

Creld2 2470.044818 3633.624043 1306.465593 0.359548918 -1.475740027 8.65E-13 1.16E-09

Atp2a3 1800.563013 2693.551182 907.5748446 0.336943605 -1.569420952 1.27E-12 1.59E-09

B3gnt3 105.9497233 199.6522812 12.24716538 0.061342477 -4.026969777 3.58E-12 4.2E-09

Ins2 111679.2675 168820.2943 54538.24068 0.323055003 -1.630148278 2.23E-11 2.46E-08

Col19a1 267.9724891 31.69556593 504.2494122 15.90914683 3.991784564 2.6E-11 2.71E-08 Sdf2l1 2018.626833 2920.690663 1116.563002 0.382294166 -1.38724491 3.31E-11 3.27E-08 Slc16a9 455.1937005 720.9586141 189.4287869 0.262745716 -1.928260856 1.4E-10 1.31E-07 Soat1 3519.151097 2030.454207 5007.847987 2.466368347 1.30238828 3.32E-10 2.86E-07 Spock1 668.9314784 1018.070891 319.7920661 0.314115715 -1.670631972 3.35E-10 2.86E-07 Snhg11 301.5786043 122.1504825 481.0067261 3.937820925 1.977397505 1.27E-09 1E-06 Derl3 385.808595 609.5304563 162.0867337 0.265920648 -1.910932294 1.28E-09 1E-06 P2ry1 2462.630633 3909.469168 1015.792098 0.25982865 -1.944367574 1.81E-09 1.36E-06 Hopx 251.0109684 411.3250579 90.69687886 0.220499279 -2.181154154 2.68E-09 1.93E-06

Etv1 1953.946158 2763.188748 1144.703569 0.414269047 -1.271360065 3.85E-09 2.67E-06

Gng12 7955.664242 10822.50454 5088.823949 0.470207606 -1.088630219 5.35E-09 3.59E-06

Phactr1 681.3450022 1002.293051 360.3969529 0.359572435 -1.475645668 6.74E-09 4.36E-06

Tmem206 1323.624671 1886.212317 761.0370254 0.40347368 -1.309453529 7.8E-09 4.88E-06

Gcg 281640.0435 379063.5643 184216.5226 0.48597792 -1.041037326 9.25E-09 5.58E-06

Cryba2 1018.684081 1475.50177 561.8663919 0.380796827 -1.392906638 9.52E-09 5.58E-06

Gast 718.7822627 1060.488062 377.076463 0.355568796 -1.491799375 9.99E-09 5.68E-06

Cecr6 241.8530889 393.8990589 89.80711886 0.227995261 -2.132924255 1.11E-08 6.15E-06

Rgs2 1218.437462 592.8805622 1843.994361 3.110229073 1.637020841 1.18E-08 6.16E-06

Cd302 110.5895978 25.47851963 195.700676 7.681006546 2.941295379 1.18E-08 6.16E-06

Cpe 21112.85464 31783.02678 10442.6825 0.328561612 -1.605764166 1.45E-08 7.37E-06 Lrrn1 1356.603034 1905.779606 807.4264621 0.423672527 -1.238978514 1.89E-08 9.34E-06 Orc6 583.9450958 869.3378576 298.5523339 0.343424977 -1.541933125 5.11E-08 2.46E-05 C6 154.6361873 41.18294716 268.0894275 6.509719337 2.702595344 1.03E-07 4.72E-05

Hyou1 5804.949595 7804.575298 3805.323891 0.487576037 -1.036300873 1.03E-07 4.72E-05 Gfra3 326.9778944 500.7002558 153.255533 0.306082394 -1.708008032 1.48E-07 6.62E-05 Nucb2 2506.110232 3398.213689 1614.006774 0.474957411 -1.074129942 1.57E-07 6.87E-05 Wnt4 1045.139527 602.3808344 1487.89822 2.470029149 1.304528068 1.69E-07 7.2E-05

Manf 2967.834744 4013.472318 1922.19717 0.478936197 -1.062094618 1.85E-07 7.72E-05

Skap1 252.9777084 108.650296 397.3051209 3.656732982 1.870555284 2.38E-07 9.56E-05

Tmem65 3310.570503 4642.729507 1978.411498 0.426131114 -1.2306307 2.4E-07 9.56E-05

Tnr 519.7101943 763.6764353 275.7439532 0.361074325 -1.469632258 2.58E-07 0.000100687

Creg2 147.1737287 49.94251998 244.4049375 4.893724578 2.290932908 6.42E-07 0.00023943

Scgn 3227.862595 4304.352535 2151.372655 0.499813302 -1.000538796 6.47E-07 0.00023943

Pak3 4995.074307 6579.994521 3410.154093 0.518260932 -0.948249452 6.61E-07 0.00023943

Cdhr1 808.5850167 1130.29229 486.8777429 0.430753839 -1.215064442 6.64E-07 0.00023943

Edn3 499.1779074 728.3377806 270.0180343 0.370731879 -1.431551916 6.86E-07 0.000242971

Mcart6 715.4497458 1019.717692 411.1817999 0.403231015 -1.310321485 7.17E-07 0.000246676

Cpm 929.2566923 528.9087421 1329.604642 2.513863993 1.329906598 7.23E-07 0.000246676 Bace2 785.1071991 1137.197935 433.0164628 0.380774929 -1.392989604 8.91E-07 0.000298507 Pgap1 3642.043277 4833.519157 2450.567398 0.506994452 -0.979958134 9.28E-07 0.000305384 Ddc 521.7895221 752.279636 291.2994082 0.387222243 -1.368766267 1E-06 0.000323893 Kif26b 57.32175194 7.649000496 106.9945034 13.98803719 3.806121631 1.16E-06 0.000369247 Slitrk6 2119.622826 2836.677111 1402.568542 0.494440674 -1.016130667 1.2E-06 0.000376216 Dnajb9 1527.684334 2133.672803 921.6958653 0.431976198 -1.210976273 1.35E-06 0.00040836 Rnf150 499.9080082 272.5922504 727.2237661 2.667807926 1.415654801 1.36E-06 0.00040836 Tln2 819.8505154 412.7644354 1226.936595 2.972486218 1.571670121 1.37E-06 0.00040836

Hsp90b1 48462.80987 62749.00782 34176.61193 0.544655814 -0.876583264 1.45E-06 0.000425799

Derl2 2042.326527 2908.866233 1175.78682 0.404207937 -1.306830443 1.64E-06 0.000474548

Zcchc18 1559.590636 2097.356831 1021.824441 0.487196277 -1.037424985 2.02E-06 0.000575323

2310015B20Rik 163.7341047 262.0691561 65.39905324 0.249548838 -2.002605912 2.06E-06 0.000575439

Gng4 1935.092229 2581.679487 1288.504971 0.499095638 -1.0026118 2.35E-06 0.000648848

Pdia4 5484.192372 7127.465809 3840.918935 0.538889844 -0.891937698 4.03E-06 0.001083058

Lipc 71.14520426 12.31207964 129.9783289 10.55697596 3.40012473 4.05E-06 0.001083058

Lrrn2 160.3187654 48.11861429 272.5189165 5.66348222 2.501689374 4.1E-06 0.001083058

Hspa5 34538.96978 44114.76451 24963.17505 0.56586894 -0.821460143 4.26E-06 0.001100841

Trpm5 324.3553314 500.4155365 148.2951263 0.296343969 -1.754655398 4.28E-06 0.001100841

Dnahc9 1069.815075 1724.033681 415.5964691 0.241060528 -2.052532657 4.45E-06 0.001126921 Zdbf2 8142.271085 10985.63247 5298.9097 0.482349079 -1.051850484 4.9E-06 0.001225879 P2ry6 168.6160838 269.1955663 68.03660117 0.252740422 -1.984271672 5.04E-06 0.001243388 Ptprt 214.5438401 329.7570298 99.33065041 0.301223754 -1.731092552 5.61E-06 0.0013657 Ace2 950.2989307 576.7665025 1323.831359 2.295263947 1.198660068 5.7E-06 0.0013703 Nudt11 316.0186897 465.0282694 167.00911 0.359137543 -1.47739162 6.04E-06 0.001433295 Crhr2 109.9867825 184.3795526 35.59401244 0.193047504 -2.372972193 6.38E-06 0.001497256 Ociad2 2121.139809 2832.408339 1409.87128 0.497764133 -1.006465817 6.63E-06 0.001535213 Aldh5a1 1446.885445 1916.1389 977.6319897 0.510209354 -0.970838747 7.45E-06 0.001703766 Ddx58 426.7109381 251.3382711 602.083605 2.395511047 1.260333467 7.57E-06 0.001710858

S100g 46.93436232 7.136076481 86.73264816 12.15410855 3.603372177 8.61E-06 0.001923781 Klf3 994.4816326 658.3551942 1330.608071 2.021109703 1.015147631 9.1E-06 0.0019902 Phf16 1376.215113 1847.669385 904.7608414 0.489676805 -1.030098234 9.12E-06 0.0019902 Hmgcr 3289.131014 4273.770465 2304.491563 0.539217438 -0.89106094 9.36E-06 0.00201906

Irx2 747.5802357 1019.894048 475.2664229 0.465995878 -1.1016109 1.06E-05 0.002254521

Spc25 887.8008159 1503.558284 272.0433481 0.180933025 -2.466472335 1.09E-05 0.0022898

Tmod2 2207.4317 2943.359457 1471.503943 0.499940277 -1.000172333 1.13E-05 0.002352135

Slc7a2 16429.83327 20950.00101 11909.66554 0.568480428 -0.814817416 1.15E-05 0.002374866

Clec9a 31.57025241 2.581601922 60.5589029 23.45787799 4.552000607 1.24E-05 0.002497556

Dapp1 674.0562539 924.894752 423.2177559 0.457584774 -1.127889048 1.24E-05 0.002497556

Peg10 44847.15404 57182.78546 32511.52262 0.568554371 -0.814629774 1.26E-05 0.002516763

Gpr155 326.3848151 479.5626346 173.2069956 0.361177004 -1.469222055 1.35E-05 0.002666491

Pdia6 6180.365898 7908.283421 4452.448375 0.563010724 -0.828765692 1.41E-05 0.002734025

Ins1 89045.71527 164846.79 13244.64052 0.080345153 -3.637645202 1.41E-05 0.002734025

Mrpl1 951.1439914 1272.555721 629.732262 0.494856337 -1.014918343 1.46E-05 0.002787906 Sytl2 150.9710671 238.3515471 63.59058717 0.266793264 -1.906205855 1.64E-05 0.003117135 Dnajc3 5733.556035 7329.30083 4137.811239 0.56455743 -0.824807748 1.78E-05 0.00330489 Slc38a5 7608.075961 9746.953439 5469.198483 0.561118766 -0.833621933 1.78E-05 0.00330489 Ret 464.4362603 652.2622108 276.6103099 0.424078393 -1.237597118 1.82E-05 0.003344297 C630004H02Rik 2394.827183 3109.172687 1680.481679 0.540491587 -0.887655934 1.84E-05 0.003348144 Clstn2 448.2134099 162.8056641 733.6211558 4.50611568 2.171884351 2.02E-05 0.003611075 Wﬁkkn2 670.05347 419.438917 920.6680229 2.194999046 1.134220313 2.02E-05 0.003611075 Rgma 154.4220528 66.25995588 242.5841498 3.661097363 1.872276141 2.31E-05 0.00409437

Rab9b 144.1020046 226.8128306 61.39117857 0.270668897 -1.885398983 2.38E-05 0.004165871

Tspan2 680.6861974 924.0883409 437.2840538 0.473205899 -1.079460037 2.42E-05 0.004193848

Cd55 340.581156 146.0889007 535.0734113 3.662656156 1.872890269 2.44E-05 0.004193848

Rtn4rl1 630.2467174 386.8277107 873.6657242 2.258539655 1.175390244 2.74E-05 0.004678535

Ptprn 964.2756596 1351.967458 576.5838616 0.426477618 -1.229458064 2.94E-05 0.004966952

Cyb5r3 5289.105215 6742.617508 3835.592921 0.56885815 -0.813859147 3.08E-05 0.005127338

Pkib 473.4375025 659.8446306 287.0303744 0.434996909 -1.200922947 3.09E-05 0.005127338

Fam107a 78.41175972 134.9338531 21.88966637 0.162225163 -2.623930475 3.3E-05 0.005430158

Glul 2397.83972 3078.702187 1716.977254 0.557695142 -0.84245139 3.66E-05 0.005966568

Sstr3 636.1714434 900.8761722 371.4667146 0.412339371 -1.278095874 3.69E-05 0.005966568

Slc7a8 3889.706592 2033.680705 5745.732478 2.825287403 1.498397634 3.76E-05 0.006027077 Sv2b 141.8203054 222.0800058 61.56060494 0.277200123 -1.851000197 4.06E-05 0.006453723 Npnt 1056.153603 718.5632615 1393.743945 1.939625945 0.955778457 4.19E-05 0.006598497 Mdm1 1290.310297 1699.248813 881.3717809 0.518683182 -0.947074504 4.51E-05 0.007052182 Snph 70.10059091 121.8146175 18.38656431 0.1509389 -2.727963434 4.75E-05 0.007362317 Mtfp1 181.2403148 277.5546583 84.92597135 0.305979269 -1.708494187 5.1E-05 0.007840672 Spcs3 5824.120492 7966.915634 3681.325351 0.462076608 -1.113796039 5.3E-05 0.008049179 Trpc7 150.7422062 55.55564513 245.9287672 4.426710672 2.146235082 5.32E-05 0.008049179 Prkag2 214.5127961 321.2794375 107.7461547 0.33536586 -1.576192265 6.05E-05 0.009031921 Mtus1 1089.603721 749.6604432 1429.547 1.906926012 0.931248869 6.07E-05 0.009031921

Pik3ip1 193.6841391 95.02077894 292.3474993 3.076669151 1.621369312 6.15E-05 0.009084713 AI836003 102.9409637 168.6253644 37.25656299 0.220942817 -2.178255067 6.21E-05 0.009102803 Cftr 173.1955039 60.67124845 285.7197594 4.709310699 2.235515908 6.45E-05 0.009383281 Tmem229b 930.1185394 1222.674809 637.5622698 0.521448766 -0.939402586 6.7E-05 0.009674012

5730469M10Rik 1141.333753 1494.105586 788.5619205 0.527781924 -0.921986154 6.76E-05 0.009687704

Slc38a1 2107.693257 1498.257692 2717.128822 1.813525694 0.858797186 6.96E-05 0.009894863

Zfp174 895.2461652 1199.354524 591.1378066 0.492879957 -1.020691779 7.04E-05 0.009930772

Cacna1c 530.9582535 769.7399986 292.1765083 0.379578181 -1.397531031 7.76E-05 0.010830793

Gcnt1 986.9507033 668.8394827 1305.061924 1.951233379 0.964386343 7.79E-05 0.010830793

Cym 51.67323095 10.66714486 92.67931704 8.688296469 3.119073333 7.97E-05 0.01099809

Svopl 75.26366218 24.19484752 126.3324768 5.221461997 2.384453815 8.28E-05 0.011335016

Lypd6b 128.4867014 55.84574211 201.1276607 3.601486042 1.848592313 8.76E-05 0.011912728

Prps1 1350.89325 1736.899398 964.8871013 0.555522733 -0.848082143 9.18E-05 0.012388764

Calb1 76.24825594 127.5163061 24.98020573 0.195898129 -2.35182448 9.58E-05 0.012834735

Gpr116 546.9335705 331.63469 762.2324511 2.298409889 1.200636105 9.89E-05 0.013157567 Cdh8 74.37361684 125.2822435 23.46499017 0.187297014 -2.416600192 0.0001028670.013502355 Sct 66.15907522 111.9976475 20.32050296 0.181436873 -2.462460413 0.0001029230.013502355 D2Ertd750e 268.9739571 386.5454174 151.4024968 0.391681003 -1.352248937 0.0001088660.014182868 Ffar3 116.6661881 185.4700979 47.8622783 0.258059271 -1.954225632 0.0001103870.014281839 Slfn10-ps 58.67671371 15.80357017 101.5498573 6.425754193 2.683865794 0.0001161370.014922823 Slit1 151.4512717 228.5450774 74.35746598 0.325351422 -1.619929235 0.0001178040.015033989 Pcsk2 14784.3662 18376.35599 11192.37641 0.609063974 -0.715334323 0.0001204280.015265014 Wdr96 137.2255509 216.8388873 57.61221458 0.26569134 -1.912176888 0.0001330790.016744574

Nefm 583.408471 837.5355133 329.2814286 0.393155184 -1.346829218 0.0001341340.016744574

Zfp462 660.9414096 431.8758984 890.0069207 2.060793214 1.043199748 0.0001347780.016744574

Fbln5 87.9121892 33.97725204 141.8471264 4.174767464 2.061695841 0.0001392150.017182102

Irx1 305.7256367 443.8702997 167.5809736 0.377544913 -1.405279817 0.0001401620.017185858

Slc35b1 1677.462801 2133.620463 1221.30514 0.572409743 -0.804879868 0.0001414380.017229669

Zim1 2566.271896 1716.441466 3416.102326 1.990223607 0.992930531 0.000143150.017325732

Fbp1 139.5577024 65.61644049 213.4989644 3.253741941 1.702099833 0.0001482530.017828357

Camk2b 1749.110518 2230.838264 1267.382771 0.568119523 -0.815733614 0.0001522040.018186941

Enpep 468.8041386 234.5895314 703.0187458 2.996803573 1.583424525 0.0001559760.018519691

Tshz2 1890.029236 1382.146267 2397.912205 1.734919279 0.79486854 0.0001604090.018926207

Syp 1328.328735 1717.794356 938.8631133 0.546551518 -0.871570604 0.0001635840.019104339 Iapp 58531.39808 75386.12511 41676.67104 0.552842728 -0.855058973 0.0001639550.019104339 Rcan3 2870.685053 3589.985741 2151.384366 0.599273791 -0.738712815 0.0001656730.019185316 Sh3rf1 233.211775 132.0216806 334.4018694 2.532931469 1.340808044 0.0001775420.020433724 Pim2 1292.12986 1747.870384 836.3893356 0.478519084 -1.063351632 0.000197360.022576116 Dnajb11 4362.748575 5412.644647 3312.852503 0.612058008 -0.708259703 0.0001995620.022689644 2610524H06Rik 524.9598853 733.6568328 316.2629378 0.431077479 -1.213980902 0.0002464480.027851623 Ssr4 1697.188473 2140.83487 1253.542075 0.58553889 -0.7721631 0.0002572830.028901997 Scnn1b 722.1722008 332.5177772 1111.826624 3.343660702 1.741428457 0.000263 0.029368344 Fam101b 463.7403922 620.5384121 306.9423723 0.494638795 -1.015552699 0.0002682730.029779863

Gpsm1 322.9128396 448.3549862 197.4706929 0.440433806 -1.183002887 0.0002761740.030476597 Arhgap36 2426.056844 3166.73611 1685.377578 0.532212827 -0.909924813 0.0002807980.030805711 Esyt3 108.2333975 168.6245483 47.84224662 0.283720532 -1.817457535 0.0002961970.032306122 Epb4.1l3 2004.010224 2528.430022 1479.590425 0.585181481 -0.773043981 0.0003006950.032607183

Rasgrf1 200.8039408 292.8837778 108.7241038 0.371219276 -1.42965647 0.0003168510.034161642

Wfs1 2643.956703 3297.354871 1990.558535 0.603683441 -0.728135866 0.0003325930.035653933

Cwc22 665.3997589 1007.533718 323.2657997 0.320848617 -1.640035332 0.0003876420.041072812

Odz3 1271.802522 924.4906627 1619.114381 1.751358284 0.808474253 0.0003885960.041072812

Fam20a 138.6799554 210.513314 66.84659687 0.317540946 -1.654985459 0.000389710.041072812

Itpr2 275.7478241 168.2204211 383.2752271 2.278410817 1.188027901 0.0003945830.04135405

Hspa13 1150.472718 1458.613233 842.332203 0.577488387 -0.792136161 0.0004011510.041808865

Prune2 1070.985448 761.3858847 1380.585012 1.813252701 0.858579998 0.0004065520.042137627

Cobl 403.4557942 258.2718483 548.6397401 2.124272327 1.086968728 0.0004379870.045146318

Sdc4 1021.958093 648.7801232 1395.136062 2.150398899 1.104604304 0.0004549310.046636656

Stat6 266.5526341 161.9735938 371.1316745 2.291309749 1.196172501 0.0004786990.048806532 Syt13 9901.57755 12077.70353 7725.45157 0.639645736 -0.644654996 0.000497070.050405623 Mob3b 486.0940384 330.5086549 641.6794219 1.941490525 0.957164667 0.0005050190.050936311 Slc25a14 329.9347649 474.0543405 185.8151892 0.391970231 -1.351184006 0.0005098730.051027334 Wdr78 133.2731339 66.62797717 199.9182907 3.000515687 1.585210473 0.0005113610.051027334 Frmd5 425.9024272 572.512911 279.2919434 0.487835188 -1.035534271 0.0005205610.051670464 Emp2 355.4204626 224.0266066 486.8143187 2.173020098 1.119701518 0.0005283910.052161179 Abat 742.3528698 960.9053349 523.8004046 0.54511135 -0.875377135 0.0005310650.052161179 Txnip 4240.217805 3241.609088 5238.826521 1.616119149 0.692533565 0.0005426260.053019076

Ostc 3129.544979 3859.045204 2400.044755 0.62192709 -0.685182635 0.0005597110.054405043

Cnn3 1664.786028 1230.375091 2099.196965 1.706143908 0.770739339 0.0005664570.054776978

Rims3 103.5761348 46.13601807 161.0162516 3.490033564 1.803240911 0.0005701020.054846775

Bmf 375.3004263 246.3972074 504.2036452 2.046304219 1.033020643 0.0005795550.055471682

2900005J15Rik 216.8276362 340.3414644 93.31380802 0.274177019 -1.866820445 0.000583570.055572407

Pdap1 914.0094068 1165.024355 662.9944586 0.569082059 -0.813291398 0.000595360.056408811

Grn 1045.827275 727.3581929 1364.296357 1.875687069 0.907419156 0.0006005090.056610773

Frem2 574.3730968 402.1994935 746.5467002 1.85616022 0.892321246 0.0006269190.058805031

Fhod3 291.7040238 397.6700335 185.7380142 0.467065654 -1.098302736 0.0006435810.060032363

Fanci 98.20007095 151.2403894 45.15975248 0.298595849 -1.743733985 0.0006464040.060032363

Srrm4 224.4046319 314.7788002 134.0304635 0.425792536 -1.231777436 0.0006524130.060283533 Tenc1 355.7318153 197.4415655 514.0220651 2.603413642 1.380404552 0.0006578090.060283533 Rgs4 834.7264783 1069.384345 600.0686113 0.561134651 -0.833581091 0.0006587490.060283533 Sh3bgrl3 568.4666604 404.8515713 732.0817495 1.808271973 0.854611683 0.0006652640.060584254 Clec1a 15.33116148 0.546927615 30.11539534 55.0628539 5.783007482 0.0006709760.0608092 Naip2 104.2820177 47.73635512 160.8276802 3.369081695 1.752355412 0.0006748320.060864681 Rbmx2 277.2677054 413.3468673 141.1885436 0.341574002 -1.549729924 0.0006781710.060873113 I830012O16Rik 26.60755656 3.936679041 49.27843408 12.51776778 3.645905413 0.0006949820.062085098 Sult1d1 348.5293371 223.5842676 473.4744066 2.117655288 1.082467767 0.000703670.062563295 Agt 112.9044265 173.4628715 52.34598146 0.301770523 -1.728476205 0.0007091180.062750276

Tspan7 4469.266819 5586.799492 3351.734146 0.599938149 -0.737114322 0.0007170860.063157477 2810433D01Rik 35.86924894 8.211458351 63.52703953 7.736389423 2.951660417 0.0007319810.064168012 Atp2a2 19397.29141 23511.86649 15282.71634 0.650000133 -0.621488082 0.0007479060.06525918 Gpr158 51.66797904 87.52769117 15.80826691 0.18060875 -2.469060304 0.0007875550.068400628

Zbtb7c 431.9077266 279.842947 583.9725062 2.08678658 1.061283061 0.0008084690.069690194

Smc6 2301.608274 2850.091041 1753.125508 0.615112108 -0.701078721 0.0008098330.069690194

Slco2a1 796.7540846 574.1941442 1019.314025 1.775207977 0.827988055 0.0008238980.070576835

Surf4 4118.597965 5032.05713 3205.1388 0.63694404 -0.650761467 0.000845250.07207677

Fmo2 505.5063806 339.7157711 671.2969901 1.976054829 0.982622978 0.0008602070.073020323

Slc26a1 219.805176 102.9783594 336.6319925 3.26895859 1.708831102 0.0008745560.073903961

B3galtl 450.8215798 304.2745304 597.3686293 1.963255447 0.9732479 0.000882810.074266912

Accn2 146.9432348 216.2862765 77.60019309 0.358784637 -1.478809981 0.0008925350.074749774

Asah1 1997.934945 1498.82939 2497.0405 1.665993819 0.736383048 0.0009164340.07566374

Ptprg 734.0909591 528.1460591 940.0358591 1.779878583 0.831778829 0.0009188560.07566374

Ccng2 256.0237494 157.5680842 354.4794145 2.249690452 1.169726506 0.0009190030.07566374 Rab3d 1066.604392 1342.854614 790.3541707 0.588562725 -0.764731919 0.0009195810.07566374 Abcg3 14.35797076 0 28.71594151 Inf Inf 0.0009265290.075886596 Cntn1 380.7978907 503.8538475 257.741934 0.511541065 -0.967078034 0.0009303790.075886596 4931429I11Rik 76.15006584 31.19165781 121.1084739 3.882720009 1.957067675 0.0009565380.07742313 Hif3a 2208.732135 1122.758264 3294.706007 2.934474955 1.553102395 0.0009574720.07742313 Lyplal1 899.2091051 1141.565471 656.8527395 0.575396468 -0.79737173 0.0010204840.08216427 Tollip 1764.494333 2189.150789 1339.837877 0.612035445 -0.708312888 0.0010321820.082455784 Prnp 2576.545753 3154.426316 1998.66519 0.633606555 -0.658340834 0.0010328950.082455784

Rpn2 4967.415751 6056.292348 3878.539155 0.640414784 -0.642921482 0.0010605350.084303521

Chrm3 218.8755141 131.8850946 305.8659337 2.319185004 1.21361791 0.0010688470.08457731

Rasgrf2 192.6774474 272.4603075 112.8945873 0.414352418 -1.271069753 0.0010729960.08457731

Nmt2 615.9043184 798.2412122 433.5674245 0.543153395 -0.8805684 0.0010929240.0857877

Galnt4 730.5028891 482.2947066 978.7110716 2.029280144 1.020968044 0.0010995150.085945404

Mcc 965.6870795 718.5659456 1212.808213 1.687817549 0.755158959 0.0011103770.086006053

Sez6l 2346.228976 1279.136688 3413.321265 2.668457013 1.416005771 0.0011127240.086006053

Glrx 496.8851695 656.1355895 337.6347495 0.514580759 -0.958530582 0.0011140440.086006053

Hip1r 519.7291101 670.7608779 368.6973423 0.549670314 -0.863361529 0.0011439150.087950164

Cbx7 192.371346 110.9482573 273.7944347 2.46776688 1.303206115 0.0011548650.088009658

Nell1 549.1113114 298.6284559 799.5941669 2.677555173 1.420916303 0.0011557080.088009658 Ece1 9626.941534 11648.28268 7605.600385 0.652937484 -0.614983229 0.0011587630.088009658 Ntng1 73.58402194 19.831758 127.3362859 6.420826931 2.682759112 0.0011665020.088240263 Fnbp1 466.2742634 328.2583116 604.2902152 1.840898444 0.880410041 0.0011746190.088449982 Slc8a1 2394.584443 2944.592116 1844.576769 0.626428618 -0.674777972 0.0011787040.088449982 Lrrc10b 381.5027171 508.4846381 254.5207961 0.500547661 -0.99842065 0.0012039990.089988096 Ufm1 1406.186412 1734.24035 1078.132474 0.621674196 -0.685769398 0.0013419220.099583459 Camk1d 781.7073579 569.3258425 994.0888733 1.746080714 0.80412025 0.0013429970.099583459 Tgfb2 366.3639085 492.2906754 240.4371416 0.488404826 -1.033850639 0.0013608160.100167459 Rgs9 338.7076437 467.1136177 210.3016697 0.45021524 -1.1513132 0.0013725840.100167459

Cd33 51.77124963 4.905554668 98.6369446 20.10719506 4.329639936 0.001373530.100167459 Dut 828.8028851 1044.270991 613.3347792 0.587332967 -0.767749477 0.0013758820.100167459 Sirpa 919.9886223 686.0941253 1153.883119 1.681814603 0.750018677 0.001377570.100167459 Igfbp7 1140.536773 856.1294827 1424.944063 1.664402514 0.735004373 0.0014019360.101545605

Slc7a14 5934.093115 7160.281321 4707.904909 0.657502785 -0.60493109 0.0014296590.102367302

Hist2h3c1 1052.066129 700.534209 1403.598049 2.003611002 1.002602439 0.0014307490.102367302

Nfe2l2 1179.777624 885.5407776 1474.014471 1.664535963 0.735120041 0.0014349730.102367302

Slc33a1 707.3430596 911.1915998 503.4945193 0.552567121 -0.855778373 0.0014351070.102367302

Chrna3 39.03158229 8.516453316 69.54671126 8.166158926 3.029657645 0.0014476680.102872137

Zdhhc24 1259.430552 1551.196161 967.6649442 0.623818553 -0.680801635 0.0014887450.105238501

A1cf 950.7386858 1250.618953 650.8584186 0.520429038 -0.942226633 0.0014967020.105238501

Tpbg 427.1521319 277.9874588 576.316805 2.073175558 1.05184229 0.0014977970.105238501

Satb1 1091.87199 816.0005081 1367.743473 1.676155173 0.745155715 0.0015040280.105281994

Brca2 455.81665 601.4562643 310.1770358 0.515710043 -0.955367955 0.0015178440.10570057

Bet1 823.068391 1042.203771 603.9330107 0.5794769 -0.787176943 0.0015212770.10570057 Tmprss6 67.14214186 24.95950403 109.3247797 4.380086221 2.130959269 0.0015384820.106501583 Mns1 146.1870131 212.4231383 79.95088796 0.376375609 -1.409754959 0.0015515010.10700793 Sdcbp2 37.18344616 66.04839616 8.318496167 0.125945468 -2.989128885 0.0015966510.109540866 Daam1 1907.715047 2358.256325 1457.173769 0.617903047 -0.694547607 0.0015999040.109540866 Ddost 4149.453231 5023.086891 3275.819571 0.652152679 -0.616718335 0.0016304920.111229184 4930583H14Rik 26.01564057 3.70394839 48.32733275 13.04751786 3.705703471 0.0016634350.113065369 Pdia3 16169.43458 19340.6076 12998.26156 0.672071004 -0.573314434 0.0017184120.116380521 Ppp1r3c 239.7485762 116.8796945 362.6174578 3.102484646 1.633424071 0.0017742750.119731649

Ikzf2 795.7737292 578.9021959 1012.645263 1.74925103 0.806737341 0.0017847850.119914381

Ndufa1 667.9725942 840.2636699 495.6815186 0.589911877 -0.761428639 0.0017897670.119914381

Ephb4 220.8621076 108.2207229 333.5034922 3.08169714 1.623725085 0.0018052370.120292163

Tnfrsf9 150.926033 232.2155408 69.63652522 0.299878832 -1.737548405 0.0018096680.120292163

Fignl1 178.3722094 251.1925024 105.5519165 0.420203292 -1.250840629 0.0018146420.120292163

Per3 597.6684121 431.3341866 764.0026377 1.771254543 0.824771554 0.0018684880.123425462

Ampd2 773.6569322 986.064756 561.2491083 0.569180781 -0.813041145 0.0019419490.127827968

Agl 805.973397 1019.936404 592.01039 0.580438533 -0.784784798 0.0019860880.129299303

D130043K22Rik 49.22066901 82.32278552 16.11855249 0.195796976 -2.352569609 0.0019909540.129299303

Gnat2 135.5872454 196.9419752 74.23251557 0.37692582 -1.407647468 0.0019962770.129299303

C2cd4c 287.6581064 387.2964638 188.0197491 0.48546725 -1.042554122 0.0019978170.129299303 Zfp568 4201.223015 5055.718952 3346.727077 0.661968576 -0.595165361 0.0019987630.129299303 Plcxd2 675.103219 851.3859385 498.8204995 0.58589234 -0.771292508 0.0020113730.129667865 Akap17b 806.5809514 1010.46186 602.7000425 0.596459962 -0.745502797 0.0020216610.129796914 Lman1 5293.057341 6349.92578 4236.188902 0.66712416 -0.583972805 0.0020272120.129796914 Rab39b 486.3565354 627.4348051 345.2782657 0.550301422 -0.861706037 0.0020440230.130212955 Maob 3252.950572 2523.581349 3982.319795 1.578042965 0.658136486 0.0020475920.130212955 Cldn5 21.19081682 2.526358055 39.85527559 15.77578266 3.979639676 0.0020638880.130805866 Resp18 855.6477302 1146.012489 565.2829709 0.493260742 -1.019577625 0.0020826770.131552281 Oxr1 1309.127512 990.3973627 1627.85766 1.643640948 0.716895178 0.0021193890.13342191

Rnasel 245.8915944 92.72503021 399.0581585 4.303672456 2.105568281 0.0021316990.133479747 Fam19a1 90.43274553 149.7871905 31.07830052 0.207483032 -2.268934734 0.0021345380.133479747 Uggt1 3333.803508 4038.005193 2629.601823 0.651213086 -0.618798404 0.0021529340.134182873 Ephb2 449.7253111 312.1644814 587.2861407 1.881335564 0.911757198 0.0021789010.135147254

Slc14a2 83.86005798 130.5602129 37.15990308 0.284618892 -1.812896671 0.0021828150.135147254

Otud7b 835.239895 623.5217253 1046.958065 1.679104388 0.747691924 0.0022007670.135810466

Nrp2 553.5155536 381.2303063 725.8008008 1.903838149 0.928910836 0.0022414370.137822429

Myt1l 337.2861284 448.4880772 226.0841795 0.504102987 -0.988209591 0.0022480630.137822429

Gpr142 61.98305089 100.0760976 23.89000414 0.238718382 -2.06661843 0.0022712740.138791848

Asap3 171.3007204 101.6784969 240.9229439 2.369458158 1.244557185 0.0023229610.140814229

Col18a1 360.5660637 246.6253428 474.5067846 1.92399848 0.944107659 0.0023238310.140814229

Tspyl5 368.6026405 481.0822781 256.123003 0.532389187 -0.909446825 0.0023268880.140814229

Prlr 191.6858786 309.0979028 74.27385439 0.240292327 -2.057137513 0.0024395 0.147154423

Rab37 729.0709254 915.4929924 542.6488584 0.5927395 -0.754529894 0.0024531560.147267397

Odz4 1316.781508 874.821132 1758.741883 2.010401691 1.00748379 0.0024570730.147267397 Ugt2b34 1354.258012 992.8464457 1715.669578 1.728031143 0.789129218 0.0024763790.14795179 Erp44 1900.636081 2295.56034 1505.711822 0.655923434 -0.608400676 0.0025222770.149870091 Abhd2 1538.295303 1868.914805 1207.6758 0.646190932 -0.629967589 0.0025313750.149870091 Fkbp2 1250.470716 1608.692311 892.2491211 0.554642497 -0.850369933 0.0025324530.149870091 Ivd 537.1298206 686.7977518 387.4618894 0.564157189 -0.825830902 0.0025469430.150253647 BC051070 13.66244745 26.62731813 0.697576771 0.026197786 -5.254411319 0.0025714760.151162738 Lmx1b 37.7228961 64.46497136 10.98082084 0.170337791 -2.553529546 0.0025784690.151162738 Plec 959.1569425 724.5848754 1193.72901 1.647466087 0.720248768 0.0026028160.152114758

Slc29a3 450.6578464 319.6292543 581.6864384 1.819878595 0.863842211 0.002644570.154074942

Bmpr2 1239.67529 970.8829651 1508.467616 1.553706955 0.635714423 0.0026703780.15508221

1810006K21Rik 956.8034987 1185.012363 728.5946346 0.614841378 -0.701713834 0.0026783920.15508221

Gp9 34.46019379 59.7808037 9.139583876 0.152884928 -2.709481907 0.0027001830.15586288

Tgif1 129.5696388 75.01440974 184.1248678 2.454526649 1.29544483 0.0027330290.157274921

Ckb 303.3762851 422.184927 184.5676433 0.437172508 -1.193725417 0.0028602370.164091893

Ephx4 100.4067171 149.5515647 51.26186952 0.342770533 -1.544685005 0.0029210620.167070478

Ell3 155.323738 235.0433191 75.60415685 0.321660523 -1.63638921 0.0029660960.169130567

Isl1 5052.926767 6044.06049 4061.793043 0.672030508 -0.573401366 0.0029767 0.169220889

Neil2 96.37242324 144.5525547 48.19229183 0.333389416 -1.584719789 0.0030413830.172375657

Nol4 989.444818 1223.237218 755.6524184 0.61774806 -0.694909519 0.0030834980.174236191 Eml6 323.2709832 445.1886648 201.3533017 0.452287575 -1.144687731 0.0031613850.178100875 Scg3 13160.67269 15596.05319 10725.29219 0.687692716 -0.540164029 0.0031776970.178483799 Cdkl1 205.4991066 131.0520669 279.9461464 2.136144458 1.095009213 0.0031954 0.178700022 Pea15a 1582.344657 1233.007205 1931.682109 1.566643002 0.647676464 0.0032073960.178700022 Higd1a 480.6182705 622.0035974 339.2329437 0.545387431 -0.874646644 0.0032101230.178700022 Irf4 12.4050504 0.384474262 24.42562654 63.52993928 5.989364735 0.0033026410.183306319 Ssr3 13331.41451 15746.31569 10916.51333 0.693274131 -0.528502166 0.0033240260.183949034 Slc7a7 126.2318543 73.16688336 179.2968252 2.450518827 1.293087231 0.0033809610.186549477 Sgms2 2888.419169 3455.297861 2321.540478 0.671878539 -0.573727647 0.0034263390.188158902

Lrrc16a 2017.012727 1591.18457 2442.840884 1.535234146 0.618458704 0.0034301890.188158902 Lmo3 127.460227 73.95896835 180.9614857 2.446782179 1.290885673 0.003465110.189520303 Ogfrl1 214.6634637 108.2325574 321.09437 2.96670778 1.568862829 0.0035096690.190995805 Mﬁ2 36.11380246 66.93417911 5.293425808 0.079084048 -3.660469478 0.0035124490.190995805

Cit 361.8404042 249.1644241 474.5163842 1.904430723 0.929359808 0.0035486730.192407807

Kcng3 181.9968181 108.5819492 255.4116871 2.352248131 1.234040253 0.0036374240.196651493

Exosc7 360.9226393 472.1385103 249.7067682 0.52888456 -0.918975236 0.0036536870.196698659

Dusp10 966.8468332 1195.752934 737.9407322 0.617134787 -0.696342476 0.0036592660.196698659

Pcdhb22 60.51575747 26.24084247 94.79067248 3.61233343 1.852931064 0.0038514870.205364598

Pstpip2 75.99695346 115.7325015 36.26140537 0.313320847 -1.674287333 0.0038527310.205364598

Rhbdl2 43.94053202 72.79243688 15.08862716 0.207282896 -2.270327015 0.0038533230.205364598

Slfn8 51.36189526 13.38315797 89.34063254 6.675601732 2.738897886 0.0038888530.20667106

Rpn1 5001.188667 5918.313679 4084.063655 0.690072185 -0.535180811 0.0039040520.206892715

4930487H11Rik 14.35607155 0.587070167 28.12507293 47.90751519 5.582180082 0.0039634280.209447622

Adam10 1847.663512 1450.067428 2245.259595 1.548382891 0.630762271 0.0040396550.212876208 Pamr1 890.0367923 680.7259219 1099.347663 1.614963714 0.691501749 0.0041253950.216478507 B630019K06Rik 790.2473513 597.7939166 982.700786 1.643878866 0.717103994 0.0041310930.216478507 Cd99l2 1062.814891 815.916293 1309.71349 1.605205706 0.68275819 0.0041672510.217764959 Kif5c 402.0524766 518.0510363 286.0539168 0.552173235 -0.856807135 0.0042144970.219622112 Gm2115 194.7089057 125.426098 263.9917134 2.104759038 1.073655077 0.0042425590.220472049 Zfhx3 2387.236562 1906.118909 2868.354215 1.504813892 0.589585073 0.0042739470.221090137 Dnajc21 909.6562929 1115.231532 704.0810536 0.631331731 -0.663529832 0.0042780230.221090137 Ccdc68 99.69219132 145.5449363 53.83944636 0.369916314 -1.434729167 0.0043029330.221766552

Slc3a2 1541.815431 1207.982202 1875.64866 1.552712165 0.634790414 0.0044312740.227755347

St3gal5 401.5309199 516.733464 286.3283757 0.554112315 -0.851749665 0.0044827260.229770333

Lrrc55 43.63631999 13.43254728 73.84009271 5.497102759 2.458671448 0.0044976350.229906369

Tmem90a 238.7153768 344.0265056 133.404248 0.387773168 -1.366715115 0.0045215810.230502328

Crybg3 645.6418393 811.6949994 479.5886792 0.590848385 -0.759140122 0.0045638670.231006771

Defb1 133.3152949 36.5304463 230.1001436 6.298859359 2.655090599 0.0045681490.231006771

Clstn1 421.2111127 291.1205944 551.301631 1.893722539 0.921224968 0.0045684170.231006771

Gnas 63204.12624 74512.55028 51895.7022 0.696469279 -0.521868377 0.0045862050.231282826

Thra 315.3976513 220.497319 410.2979836 1.860784455 0.89591095 0.0046142640.231773889

Ypel2 2414.575899 1757.711166 3071.440631 1.747409182 0.805217476 0.0046211890.231773889

Aatk 216.5277175 288.7891949 144.2662401 0.499555533 -1.001283032 0.0046330070.231773889 Id3 111.0760962 58.17327331 163.978919 2.818801655 1.495081966 0.0046808570.232700221 Cbln2 18.89043937 37.08330197 0.697576771 0.018811075 -5.7322739 0.0046835380.232700221 Azin1 2343.128147 2796.264908 1889.991387 0.675898546 -0.565121383 0.0046887360.232700221 Slc5a1 79.02287725 118.59629 39.44946451 0.332636582 -1.587981257 0.0047090180.233090192 Smarca1 2607.511268 3119.960528 2095.062008 0.671502729 -0.574534833 0.0047610430.235045153 Prss23 323.4347958 197.791187 449.0784047 2.270467211 1.182989202 0.0047889380.235801776 Ncapg2 357.6781933 464.2714964 251.0848903 0.540814787 -0.886793498 0.0048384490.237616001 Uso1 3779.126157 4499.980336 3058.271977 0.679618965 -0.557201984 0.0048738140.238727804 Vipr1 53.00266929 85.92117932 20.08415925 0.233750973 -2.096955726 0.0048889190.238844049

E2f8 173.2906569 245.8509945 100.7303194 0.409721017 -1.287286198 0.0049281290.240030697 Sytl3 44.08547782 14.47778002 73.69317562 5.090088089 2.347690624 0.0049387980.240030697 Klhl21 1035.874469 1252.842027 818.906911 0.6536394 -0.613433145 0.0049906970.241926284 Slc17a4 51.68509679 20.6639033 82.70629027 4.002452444 2.000884261 0.0051260160.247143076

Obsl1 334.4603324 233.4945273 435.4261375 1.864823739 0.899039275 0.0051306610.247143076

Efs 86.32725042 31.42643013 141.2280707 4.493926613 2.167976565 0.0051378360.247143076

Ficd 512.7045141 642.9176626 382.4913656 0.594930561 -0.749206805 0.0051664720.247393203

Tmem50b 1509.43599 1807.553433 1211.318548 0.670142595 -0.577459986 0.005169410.247393203

Plxna1 603.4602165 456.0604636 750.8599695 1.646404434 0.719318773 0.0053104580.253324304

Fmn2 1369.273576 1756.368005 982.1791472 0.559210339 -0.838537061 0.0053203510.253324304

St6gal1 1663.564596 1309.722441 2017.406751 1.540331515 0.623240886 0.0053451150.253859153

Kcnmb2 677.9113327 837.3247167 518.4979487 0.619231629 -0.691448931 0.0053706560.254428051

Nrcam 67.23122483 102.3454415 32.11700812 0.313809855 -1.672037437 0.005458170.257437331

Galns 369.8514403 475.5900724 264.1128081 0.555337093 -0.848564334 0.0054616240.257437331

Parvb 56.24977668 22.20465529 90.29489806 4.066485017 2.023782298 0.0056114780.263423792 Sema3f 215.268294 139.6294695 290.9071185 2.083422071 1.058955138 0.0056211910.263423792 Tmed3 2221.399252 2663.346692 1779.451812 0.66812624 -0.581807374 0.0056307540.263423792 Tspan13 2270.48461 2691.511554 1849.457666 0.687144614 -0.54131434 0.0057108860.266507991 Aif1 35.72347231 10.13868484 61.30825978 6.046963756 2.596210932 0.0057418810.267289527 Ghsr 52.32355222 83.39157324 21.2555312 0.254888238 -1.972063292 0.0057700010.267933729 Prkcb 2177.505216 2609.456105 1745.554328 0.66893416 -0.580063875 0.0057979270.268106588 4922501L14Rik 29.03885229 52.82651493 5.251189648 0.099404431 -3.330546031 0.0058023070.268106588 Bcl6 107.8405029 60.8266345 154.8543713 2.54583165 1.34813702 0.0058199390.268260584

Aqp4 352.4359901 455.1189354 249.7530447 0.548764345 -0.865741346 0.0058464490.268822009

Folr1 212.6716223 122.5979593 302.7452853 2.469415374 1.304169529 0.0059569680.273234024

Zfp467 321.4113116 229.7578274 413.0647957 1.79782687 0.846254097 0.0059928430.27360895

Mbd2 1578.420231 1889.148289 1267.692173 0.671038997 -0.575531485 0.0059943110.27360895

Camk2n2 287.4216672 373.5435235 201.2998108 0.53889252 -0.891930532 0.0060126890.273781663

Fmnl2 1172.604533 1420.483967 924.7250995 0.650992986 -0.619286095 0.0060716790.275798302

Ptpn13 1149.774287 917.6952382 1381.853336 1.505786756 0.590517476 0.0061391310.27818855

Ogt 2533.528577 2058.677116 3008.380039 1.461317084 0.547269255 0.0061539580.27818855

Jph4 117.5712906 169.1301856 66.01239564 0.390305228 -1.357325308 0.0061875280.279033729

9130014G24Rik 355.1354017 470.2637471 240.0070563 0.510366912 -0.970393296 0.006238870.280474297

AU015836 32.55511855 8.617798166 56.49243893 6.555321655 2.712666572 0.0062493740.280474297 Rasgef1c 28.66543369 50.06291741 7.267949967 0.145176317 -2.784121973 0.0062843130.281369263 Spink4 80.11261763 120.4408734 39.78436182 0.330322761 -1.598051713 0.0063389850.28314133 Il6ra 385.7868735 494.9602567 276.6134903 0.558860003 -0.83944117 0.0064585140.287795081 Med13l 881.1560508 685.3492908 1076.962811 1.571407201 0.652057077 0.0065147210.289611752 Nfatc1 537.730831 404.2590657 671.2025964 1.660327877 0.731468169 0.0065762290.291654986 Gpd1 263.8718128 348.3980971 179.3455285 0.514771837 -0.957994968 0.0066058950.292279689 Adam23 226.3600715 303.255073 149.4650701 0.49286915 -1.020723413 0.0066233910.29236429 Gnai1 3442.960155 4493.567606 2392.352705 0.532394951 -0.909431205 0.0066394220.29238392 Blcap 396.3270425 505.2209807 287.4331043 0.56892551 -0.813688323 0.0066981050.294277411

Sox4 430.6527922 314.2717036 547.0338808 1.740639944 0.799617809 0.0067156850.294360399 Adam15 126.8139566 77.20854935 176.4193638 2.284971876 1.192176408 0.0067326760.294417244 Gm10941 106.94513 153.699233 60.19102706 0.391615663 -1.352489626 0.0067643270.295113425 Hdac7 303.439712 212.6921991 394.1872248 1.853322437 0.8901139 0.0067910760.295323092

Plch1 756.935996 927.7078179 586.1641742 0.631841365 -0.662365705 0.0068006170.295323092

Arrdc4 921.9503023 720.6111648 1123.28944 1.558801049 0.640436808 0.0068284650.295847599

Itfg3 842.3632266 645.2137002 1039.512753 1.611113888 0.68805848 0.0068857880.297643757

Cnot6l 3652.417196 4304.540086 3000.294305 0.697006938 -0.520755078 0.0069709960.300437807

She 17.90227206 2.520741824 33.2838023 13.20397114 3.722899985 0.0069824560.300437807

Ccnb2 193.5967599 261.7547208 125.438799 0.479222681 -1.061231905 0.0070566360.302922246

Pid1 161.2192168 83.45648271 238.9819509 2.863551675 1.517805638 0.0070724920.302922246

Treml2 9.689677668 0 19.37935534 Inf Inf 0.0071006920.303437335

Adora3 137.2715802 190.3515266 84.19163373 0.442295553 -1.176917358 0.0071694390.305678829

Wls 1333.430032 1003.603162 1663.256902 1.657285435 0.7288221 0.0071907630.30589276

Cat 1166.359044 912.6040832 1420.114004 1.556111823 0.637945737 0.007228730.306812142 Gpx3 3723.821462 4655.086051 2792.556873 0.599893717 -0.737221174 0.0073218640.309710178 7630403G23Rik 24.59025879 43.70915938 5.471358211 0.125176468 -2.997964715 0.0073300280.309710178 Smo 385.3523598 255.9815747 514.7231448 2.010782008 1.007756685 0.0073726350.310810395 Asap1 798.6227683 609.5168686 987.7286679 1.620510799 0.696448635 0.0074634420.313933104 Mtap9 2121.869217 2521.719292 1722.019143 0.682875032 -0.550306509 0.0075347690.315850581 Magt1 4986.157632 5845.248786 4127.066477 0.706054888 -0.502147753 0.0075534710.315850581 Sntb2 663.3452444 509.9006316 816.7898572 1.601860846 0.679748826 0.0075654720.315850581 Tssc4 473.5036479 593.4262595 353.5810363 0.595829778 -0.747027868 0.0075763730.315850581

Ccnd2 5208.444659 6944.255324 3472.633993 0.500072914 -0.999789631 0.0077420240.322040728

Gm5567 999.2320012 1215.828897 782.635105 0.643704971 -0.635528485 0.0077635550.322221896

Pitpnc1 1653.687471 1327.127235 1980.247707 1.492131015 0.577374215 0.0077838730.322352008

Itga4 4282.966291 3511.921868 5054.010714 1.439101126 0.525167974 0.0078161150.322974249

Srpr 1660.109266 1980.212382 1340.00615 0.676698198 -0.563415549 0.0079098080.326127486

Gad2 57.44357447 16.82135282 98.06579612 5.829840035 2.543456298 0.007939650.326639993

Ptprn2 8795.132121 10549.44052 7040.823719 0.667412049 -0.583350362 0.0079915790.327918914

Tns3 2951.309911 2387.48043 3515.139393 1.472321762 0.558092993 0.0080056960.327918914

Sec61b 1500.953875 1797.687508 1204.220241 0.669871842 -0.578042986 0.0080584930.329362353

Bicd1 914.8408628 1105.889859 723.7918664 0.654488203 -0.611560907 0.0081041950.330510231

Xiap 1633.528629 1313.117777 1953.939481 1.488015405 0.573389462 0.0081953620.333503227 Crp 131.6149009 189.5504282 73.67937362 0.38870592 -1.363249014 0.0082887260.335957447 Zdhhc9 525.7934136 400.0318652 651.554962 1.628757653 0.703771958 0.0082914870.335957447 Gabrg2 13.32602704 25.16908797 1.48296611 0.058920137 -4.085095406 0.0083379980.336629433 Abhd15 636.5503552 780.2977006 492.8030099 0.631557686 -0.663013581 0.008343960.336629433 Cdc25b 79.94033306 119.6124887 40.26817747 0.336655293 -1.570655945 0.0084148960.338424539 Dennd1c 275.8296155 195.1719775 356.4872535 1.82652888 0.869104565 0.0084245340.338424539 Lamc2 240.6789254 169.9547119 311.403139 1.832271289 0.873633127 0.0084472830.338613297 Slc8a3 14.11867968 0 28.23735937 Inf Inf 0.0084915040.339660153 Timd4 14.41296101 0 28.82592202 Inf Inf 0.0085515690.341334969

Micalcl 83.86028708 123.121778 44.59879617 0.362233204 -1.465009297 0.0086943140.346295811 Kcnn3 217.6936661 145.3867071 290.0006251 1.994684596 0.996160642 0.0088019920.349841883 Vwde 39.22890717 64.07123879 14.38657556 0.224540306 -2.154953657 0.0088510140.351046557 Lzts2 280.4699459 194.9517426 365.9881491 1.877326893 0.908679884 0.0089408370.353860966

Mafa 26.80315906 46.1255668 7.480751323 0.162182318 -2.624311561 0.0089716190.354083566

Scfd1 1413.574426 1685.930948 1141.217904 0.67690667 -0.562971161 0.008984210.354083566

Oprl1 92.88949508 50.18886019 135.59013 2.701598113 1.433813077 0.0090543420.355876881

Lilrb3 11.20660199 0 22.41320399 Inf Inf 0.0090676520.355876881

Nptx1 353.4424327 448.0754559 258.8094095 0.57760229 -0.791851633 0.0091060910.356639406

Dennd2d 164.8123974 224.9873244 104.6374704 0.465081625 -1.104444154 0.0091251570.356641537

Gale 252.2052649 326.0041812 178.4063485 0.547251719 -0.869723514 0.0091605070.357278799

Bach1 403.3445385 296.6202082 510.0688687 1.719602558 0.782075161 0.0092304330.35925916

Ssr2 4135.119839 4836.727775 3433.511903 0.709883223 -0.494346376 0.0093806580.36408015

Scnn1g 149.8445242 76.65878694 223.0302614 2.90938939 1.540716398 0.0093971030.36408015

Rps6ka1 120.5585426 75.86659378 165.2504913 2.178172014 1.123117891 0.009423590.36408015 Cnr1 166.2428943 106.6270712 225.8587173 2.118211771 1.082846832 0.009446240.36408015 Ptplb 508.5514119 661.9806605 355.1221633 0.536453985 -0.898473668 0.0094520850.36408015 Gip 104.0574028 150.4795616 57.63524396 0.383010446 -1.384544356 0.0094895020.36408015 Cdk5r2 141.5899972 196.6504064 86.52958804 0.440017336 -1.184367729 0.0094901490.36408015 Upp1 134.7464682 184.3107566 85.1821799 0.46216608 -1.113516715 0.0095113970.364150638 Akap6 162.4978489 221.7609596 103.2347382 0.465522599 -1.10307689 0.0095848390.366215041 Gm20554 274.0866509 356.424318 191.7489837 0.53797952 -0.894376841 0.0097039090.369278228 Gspt2 355.4633859 461.2185433 249.7082285 0.541409777 -0.885207155 0.009704380.369278228

Mical1 42.13834251 16.58548846 67.69119657 4.081350799 2.029046718 0.0098066620.372414939

Steap2 1115.905709 1348.327793 883.4836255 0.655243948 -0.609895972 0.0098520590.373383095

Myo3a 66.30201102 28.09377697 104.5102451 3.720049647 1.895321875 0.0099782330.377401938

Il1r1 4023.748726 5595.662885 2451.834567 0.438166955 -1.19044741 0.0099983350.377401938

Yipf6 3686.788321 4309.625626 3063.951016 0.710955262 -0.492169316 0.0100722210.379427431

Utp14b 240.7221665 169.3772926 312.0670403 1.842437292 0.881615518 0.0101785040.382662797

Fbxo32 342.6260204 243.955396 441.2966448 1.808923484 0.855131384 0.0102437940.384323492

Prc1 333.0910085 439.1985222 226.9834949 0.516812975 -0.952285805 0.010263650.384323492

Rxra 690.7466291 541.4668097 840.0264485 1.55139047 0.633561845 0.0103323410.386124944

Gpx7 133.6138788 82.55134094 184.6764166 2.237109834 1.161636089 0.0103827740.387238245

Lgals7 7.070398692 14.14079738 0 0 #NAME? 0.0104627270.389406078 Steap1 60.02939637 90.94207505 29.11671769 0.32016773 -1.643100192 0.0105172870.389406078 Fbln2 618.1482906 281.8334068 954.4631745 3.386621854 1.759846906 0.0105219440.389406078 Ppt2 74.16246438 39.54915105 108.7757777 2.750394758 1.4596387 0.0105673620.389406078 Galr1 147.7344374 200.9419518 94.52692299 0.470419055 -1.087981596 0.0105873250.389406078 Cd200 1610.622722 1904.033634 1317.21181 0.691800705 -0.531571611 0.010592080.389406078 Clspn 139.8622763 193.1619094 86.56264322 0.44813516 -1.157994172 0.0105990710.389406078 Calcrl 97.85443146 39.83921514 155.8696478 3.912467834 1.968078891 0.0106272750.389406078 Itm2c 1327.030503 1584.611334 1069.449672 0.674897149 -0.567260435 0.0106314390.389406078 Akap13 2886.067058 2410.158619 3361.975497 1.394918771 0.480181113 0.0106484710.389406078

Scnn1a 62.95020103 30.03422015 95.86618191 3.191898489 1.674414771 0.0106727470.389534494 Atp6v0e2 568.9450011 697.2968445 440.5931577 0.631858815 -0.662325863 0.0107319770.390662802 Wbscr17 79.02383325 34.53214246 123.515524 3.576827709 1.838680628 0.0107453090.390662802 Usp6nl 516.7799639 390.0919765 643.4679512 1.649528803 0.72205397 0.0108617720.393295318

Sorbs3 272.1848199 156.1447908 388.2248491 2.486313165 1.314008023 0.0108712540.393295318

Dph3 603.7424948 755.5860749 451.8989146 0.598077346 -0.741596022 0.0108806110.393295318

Tmem117 108.8443658 153.4033895 64.28534212 0.419060767 -1.254768633 0.0110032630.39696386

Sod1 4111.725014 4781.370064 3442.079964 0.719894072 -0.474143457 0.0110467060.397766245

Fcho2 1194.365312 966.8572259 1421.873399 1.470613613 0.556418245 0.0111955780.402354489

Ermap 7.456173752 0 14.9123475 Inf Inf 0.011289580.403571088

Tshr 17.63957211 2.549584031 32.72956019 12.83721572 3.682260423 0.0112921650.403571088

Chd3 1351.958116 1044.165666 1659.750566 1.589547156 0.668615817 0.0112976530.403571088

Gch1 2207.988084 2622.350519 1793.625649 0.683976316 -0.547981724 0.0113154790.403571088

Mmp14 558.5854698 349.8267992 767.3441404 2.193497302 1.133232932 0.0114244220.405517867

Pik3c2b 220.819832 153.4141529 288.2255111 1.87874134 0.909766454 0.0114304090.405517867 4933417E11Rik 113.4693878 158.5126217 68.42615392 0.431676375 -1.211977956 0.0114500310.405517867 Scly 367.3240771 464.7505734 269.8975808 0.580736413 -0.7840446 0.0114565280.405517867 Hells 254.359005 330.2178885 178.5001215 0.540552549 -0.88749322 0.0115069430.406317285 B230217C12Rik 228.2554853 299.7114 156.7995706 0.523168523 -0.934652352 0.0115345080.406317285 Mas1 41.88760404 69.02075731 14.75445076 0.213768312 -2.225880086 0.0115623410.406317285 Vps35 2260.050703 2674.011153 1846.090253 0.690382406 -0.534532397 0.0115657480.406317285 Pbk 345.2211508 498.7836333 191.6586684 0.38425212 -1.379874877 0.0116644570.409019101 Cecr5 190.0970978 254.0004118 126.1937838 0.496825115 -1.00918999 0.0117726170.411776169

Phlda1 340.9367693 257.5366219 424.3369167 1.647676022 0.720432597 0.0117960970.411776169

Alg12 233.3995025 305.1609768 161.6380282 0.529681186 -0.916803828 0.0118089330.411776169

Fam18b 1800.934844 2123.403229 1478.466459 0.696272116 -0.522276847 0.0118559010.412646939

Ptprm 427.4158441 278.9041434 575.9275449 2.064965898 1.046117956 0.0118931740.412972204

Gm13483 8.968075426 0.238937487 17.69721336 74.06629082 6.210745185 0.0119092730.412972204

Gstm2 146.4551622 87.85745305 205.0528714 2.333926881 1.222759364 0.0119810610.414695021

Ube2c 369.522085 469.2903809 269.7537891 0.574812099 -0.798837665 0.0120103350.414942692

Th 152.1380104 210.3786215 93.89739936 0.446325766 -1.163831001 0.0120805440.416601118

Lrpprc 2589.927826 3016.847974 2163.007678 0.716976028 -0.480003211 0.0121204 0.417006575

Lyrm5 331.5639238 414.0601101 249.0677376 0.601525555 -0.733302065 0.0121367590.417006575

Zwilch 150.1318702 203.3073194 96.95642108 0.476895871 -1.068253804 0.0122359770.419647038 Cntnap5b 75.00638486 110.3534638 39.65930592 0.359384332 -1.47640058 0.012305050.421245887 Zfp108 103.0572748 143.4831554 62.63139407 0.436506947 -1.195923481 0.0123809730.422902541 Znrf1 595.8467568 472.5236647 719.1698489 1.521976363 0.605945954 0.0124268230.422902541 Tmem66 2198.224577 2577.653684 1818.795469 0.705601176 -0.503075131 0.0124466810.422902541 BC053749 256.8015226 186.5249286 327.0781166 1.753535675 0.810266782 0.0124560590.422902541 Paxip1 1131.118062 1367.233788 895.0023354 0.654608117 -0.611296603 0.0124912610.422902541 Slc9a9 164.297218 92.50215562 236.0922803 2.552289498 1.351791979 0.0125096370.422902541 2010016I18Rik 7.308024991 14.61604998 0 0 #NAME? 0.0125112430.422902541 Gtpbp1 876.1891697 1096.20521 656.1731298 0.598586035 -0.740369474 0.0125545920.423604571

Tead1 4929.935594 4102.248953 5757.622235 1.403528235 0.489058087 0.0128137630.431456976 Palld 84.74037828 48.10959264 121.3711639 2.522805895 1.33502921 0.0128333150.431456976 Kank3 139.3335128 86.42273939 192.2442862 2.224464158 1.153457853 0.0129780190.435541381 Arhgef26 75.38160993 40.92842891 109.834791 2.683581898 1.424159917 0.0130227670.4362627

Dlgap5 264.5015836 344.8169614 184.1862058 0.534156455 -0.904665723 0.0131853210.440920897

Alg2 2327.890383 2734.124742 1921.656025 0.702841387 -0.508728949 0.0133013480.444009426

Bmp4 9.732787994 0.431174618 19.03440137 44.14545891 5.464193135 0.0134745030.448366075

Unc50 1562.193768 1871.892439 1252.495097 0.669106339 -0.579692583 0.0134796620.448366075

Naa38 786.3658269 947.239519 625.4921349 0.660331545 -0.598737528 0.0135113760.448625496

Vat1 377.0749418 280.8898327 473.2600509 1.684860026 0.752628741 0.0135732670.449884271

Ppp1r3f 89.83297484 129.5030946 50.16285507 0.387348698 -1.368295205 0.0136339620.451099001

Dtx4 205.073729 140.1307395 270.0167185 1.926891411 0.946275272 0.0138219010.456003821

Camkk2 129.9835769 82.7968899 177.1702639 2.139817862 1.097488002 0.013830820.456003821

Btrc 1056.0463 847.2022864 1264.890313 1.493020419 0.578233897 0.0139622360.459529035

Trim9 242.8130857 312.6213085 173.0048628 0.553400738 -0.853603528 0.0141059030.463444364 Myo1f 48.5021411 7.363030529 89.64125166 12.17450496 3.605791205 0.0141357930.463614479 Pde6b 12.92325907 24.3178039 1.528714241 0.062863992 -3.99162229 0.0141777530.464179154 Rangap1 2175.679833 2537.038748 1814.320918 0.71513331 -0.48371589 0.0142641760.466195031 Atp5l 183.6935584 241.825712 125.5614049 0.519222724 -0.94557457 0.014428420.469491597 6330403A02Rik 40.79076857 15.39891992 66.18261722 4.297873979 2.103623181 0.0144340560.469491597 Galnt10 451.3371771 342.4972141 560.1771402 1.635566998 0.709790858 0.014440120.469491597 Acss2 196.3186385 135.4900951 257.1471819 1.897903914 0.924406955 0.0144920650.470237114 Mcm2 453.442224 566.3904313 340.4940166 0.601164846 -0.734167446 0.0145131820.470237114

Dock3 27.67835072 47.30866373 8.048037701 0.170117629 -2.555395443 0.0146392790.47350495

Mis12 668.9944547 816.8526894 521.13622 0.637980663 -0.648415399 0.0146793540.473983946

Iﬁh1 196.0163019 258.4895884 133.5430153 0.516628218 -0.952801651 0.0147258540.474668407

Klf5 120.0768547 74.80295108 165.3507584 2.210484427 1.14436257 0.0147566080.474843843

Dach1 700.4895118 851.5387057 549.4403179 0.645232347 -0.632109328 0.0147850730.474945145

Zfp597 541.1193433 667.452989 414.7856976 0.621445562 -0.686300078 0.014835290.475743672

BC013712 12.8966345 1.598757148 24.19451186 15.13332522 3.919657118 0.0148872220.476594329

Ccdc89 19.0881444 3.173346748 35.00294205 11.03029225 3.463399111 0.0149373910.477385775

Robo1 1115.727961 873.957037 1357.498885 1.553278739 0.635316748 0.0150259370.478715455

Nav1 2896.581 2294.52878 3498.63322 1.524771993 0.608593525 0.0150393410.478715455

Fam23a 10.78103698 0.273463807 21.28861016 77.84799885 6.282588049 0.015055550.478715455 Spock2 4950.545403 3909.887788 5991.203018 1.532320962 0.615718518 0.0151346 0.480366505 2410021H03Rik 92.16311264 129.5319278 54.79429744 0.423017694 -1.241210085 0.0152258020.480366505 6430548M08Rik 291.4796203 369.505269 213.4539716 0.577675041 -0.791669931 0.0152381520.480366505 Cd48 17.95872764 0 35.91745528 Inf Inf 0.0152401630.480366505 Banp 586.3925594 719.2401073 453.5450114 0.630589155 -0.665227737 0.0152729120.480366505 Btbd11 49.36455147 22.80237178 75.92673117 3.329773407 1.735424005 0.0152845640.480366505 Ctxn1 612.5697864 480.1595445 744.9800284 1.551526023 0.633687895 0.0152920080.480366505 Cd28 13.09014737 1.093855229 25.0864395 22.93396679 4.519414008 0.0153240210.480366505 Efnb1 162.2973977 107.3079212 217.2868742 2.024891282 1.017844451 0.0153621110.480366505

Gars 3665.49274 4279.255585 3051.729895 0.71314504 -0.487732572 0.0153635340.480366505 Fxyd6 955.5083161 1148.668984 762.3476485 0.663679145 -0.591442155 0.0154492850.482243915 Apoa1 6.551866365 13.10373273 0 0 #NAME? 0.0155308390.483984278 Arhgef2 944.0552144 767.5816225 1120.528806 1.459817136 0.545787662 0.0156216950.486008298

Samsn1 37.91548391 1.969071667 73.86189615 37.51102481 5.229242773 0.0156545090.486222838

Gata6 732.00933 578.1683548 885.8503052 1.532166709 0.61557328 0.0157917960.489676199

Gpc4 2192.014736 2555.792157 1828.237316 0.715330983 -0.483317165 0.0158992160.491988122

Evc2 87.89834032 50.59003154 125.2066491 2.474927279 1.307386135 0.0159443630.491988122

Cysltr1 14.00439672 1.490503526 26.51828991 17.7914976 4.15311605 0.0159450310.491988122

Rapgef4 1217.860602 1452.485561 983.2356428 0.676933161 -0.562914702 0.0160050850.492184694

Spcs1 1904.445553 2221.35526 1587.535845 0.714669947 -0.484650974 0.016007230.492184694

Fgb 39.62898959 63.96543464 15.29254454 0.239075129 -2.06446404 0.0160301090.492184694

Scn3a 576.0909886 696.6649531 455.5170242 0.653853796 -0.612960015 0.0161458380.494927969

Rit2 44.04491005 69.35469125 18.73512885 0.27013499 -1.888247572 0.0163304130.499769235

Cmtm8 76.6588831 42.53906842 110.7786978 2.6041637 1.38082014 0.0164061350.501268892 Clec4n 20.59822905 0.961185656 40.23527244 41.86004253 5.387501872 0.0164504570.50180581 Tada1 557.0137812 682.7290019 431.2985605 0.631727317 -0.662626137 0.0164973530.502419379 Nup88 2334.012523 2720.738794 1947.286253 0.715719663 -0.482533479 0.0166064870.504604848 Ccdc163 146.1647853 96.04739711 196.2821736 2.04359701 1.03111073 0.016622910.504604848 C77080 587.7058989 463.5396323 711.8721655 1.535730962 0.618925499 0.0166713340.505257243 Aplnr 58.08497485 28.04633854 88.12361117 3.142071862 1.651716177 0.0167010470.505341363 Jagn1 836.8830489 1006.339897 667.4262012 0.663221446 -0.592437437 0.0170089350.512421452 Syn2 165.6314428 219.6064798 111.6564058 0.508438576 -0.975854602 0.0170538360.512421452

Rbp4 12414.25131 14408.6973 10419.80533 0.723160818 -0.467611582 0.0170542380.512421452

Herpud1 909.9598582 1089.561247 730.3584691 0.670323464 -0.577070661 0.0170687020.512421452

Kcnj5 569.0877102 438.9272598 699.2481606 1.593084378 0.671822681 0.017071610.512421452

BC017647 2227.813709 1864.77611 2590.851309 1.389363203 0.474423793 0.0171374050.513451477

Flii 775.2045866 625.9963019 924.4128713 1.476706601 0.562383213 0.0171899510.513451477

Tmem106a 90.49212519 51.99213106 128.9921193 2.480993117 1.310917733 0.0172035580.513451477

Bcorl1 331.557469 245.3795968 417.7353413 1.702404547 0.767573909 0.0172875590.513451477

4931417G12Rik 33.00247943 54.35743816 11.6475207 0.214276483 -2.22245457 0.0172918480.513451477

Hist1h1c 1156.144778 934.2452641 1378.044292 1.475034817 0.560749008 0.0172965550.513451477

Necap1 1690.811255 1978.145874 1403.476636 0.70949097 -0.495143771 0.0172975120.513451477

Folr2 32.40750376 12.22806145 52.58694606 4.300513721 2.104509008 0.0173776980.515016764 Rhoc 156.7148678 103.2970731 210.1326625 2.034255727 1.024501052 0.0174661860.516127469 Rrm2 526.468936 732.8809784 320.0568936 0.436710602 -1.195250538 0.0174702 0.516127469 Cdc14a 292.7093372 208.005612 377.4130623 1.814436922 0.859521903 0.0176284060.51998254 Cdk1 302.4374801 385.1570407 219.7179195 0.570463204 -0.809794262 0.0177787930.523595231 Atp2b4 837.4745559 683.163555 991.7855568 1.451754195 0.537797203 0.0178670110.525129205 Casq2 13.95218335 25.99634789 1.908018814 0.073395649 -3.768161658 0.0179336060.525129205 Lrrtm2 151.2041784 204.6225273 97.7858294 0.477883988 -1.065267665 0.0179372540.525129205 2810407C02Rik 3769.294189 4335.959998 3202.62838 0.73862037 -0.437095044 0.0179428480.525129205 Klb 323.0409676 405.8869062 240.1950291 0.591778216 -0.756871506 0.0182585380.533536086

Lars 1715.982655 2007.932662 1424.032648 0.709203389 -0.495728666 0.0183799770.53559091 Rem2 231.222993 294.2813373 168.1646487 0.571441771 -0.807321596 0.0184040760.53559091 Nxnl2 18.87886813 4.819745823 32.93799043 6.833968354 2.772723567 0.0184145060.53559091 A630001G21Rik 10.60039123 0.313606359 20.8871761 66.60316501 6.057518831 0.0185148 0.537168441

Arhgap25 18.56213273 3.753508143 33.37075732 8.890551466 3.15227291 0.0185852020.537168441

Tnfrsf21 487.1406844 374.6086051 599.6727637 1.600798155 0.678791409 0.018596240.537168441

Dck 595.4894443 793.888758 397.0901306 0.500183592 -0.999470363 0.0186062830.537168441

Coch 65.21342948 96.44885551 33.97800345 0.352290375 -1.505163037 0.0186377930.537168441

Umodl1 14.01857839 26.98671219 1.050444597 0.038924512 -4.683177245 0.0186631990.537168441

Relt 109.5610641 149.6738293 69.44829892 0.463997609 -1.107810724 0.018669180.537168441

C2cd2l 570.3377967 693.028274 447.6473194 0.645929374 -0.630551665 0.0187216240.537852478

Sh3bp5 153.8878412 105.1378455 202.637837 1.927353905 0.946621507 0.0189343540.543132235

Mfsd6l 57.47587804 84.82421328 30.12754281 0.355176213 -1.493393132 0.0191086440.546030102

Slc25a45 24.72798661 7.827857778 41.62811544 5.317944784 2.410868798 0.0191155740.546030102

Nme2 1238.788211 1457.758667 1019.817756 0.699579278 -0.515440538 0.0191624290.546030102 Pde10a 151.805143 203.9256959 99.68459013 0.488828 -1.032601169 0.0191800160.546030102 4930452B06Rik 60.01686542 88.5281746 31.50555624 0.355881688 -1.490530393 0.0191809080.546030102 Pnma2 66.72214609 98.21739512 35.22689707 0.358662506 -1.479301159 0.0193038 0.548271241 Gstz1 2891.119342 3391.55591 2390.682774 0.704892633 -0.504524568 0.0193180860.548271241 Glb1l2 1573.216224 1842.95347 1303.478978 0.707277204 -0.499652331 0.0193686490.548415773 Abcb10 898.912958 1061.352271 736.4736453 0.693901229 -0.527197772 0.0193816450.548415773 Trp53inp1 1196.965497 970.1347945 1423.796199 1.467627187 0.553485535 0.0195135720.55051302 Ccdc24 86.65617964 53.25700646 120.0553528 2.254264008 1.172656486 0.0195144540.55051302

Atp4a 52.43787875 80.48927172 24.38648579 0.30297809 -1.722714628 0.0196316890.552988725

D830031N03Rik 478.374674 376.4199779 580.32937 1.541707147 0.624528746 0.0197086560.55353266

Blvrb 60.96874967 31.72841855 90.2090808 2.843163477 1.507497054 0.0197100120.55353266

Tmem22 419.5420009 512.6659551 326.4180468 0.636707087 -0.651298273 0.0197665090.554289552

Gm10538 34.3750694 56.70214311 12.04799569 0.212478665 -2.234610105 0.0199080380.556585765

Senp5 801.9848921 954.2123919 649.7573924 0.680935815 -0.554409279 0.0199427680.556585765

Susd4 89.05579761 51.22890562 126.8826896 2.476779234 1.308465281 0.0199674790.556585765

Tmem88b 63.12497009 92.78208045 33.46785972 0.360714694 -1.471069903 0.0199765960.556585765

Galnt13 272.340697 367.6180907 177.0633032 0.481650135 -1.053942524 0.0200011310.556585765

Orc1 64.26093681 92.8902675 35.63160612 0.383588153 -1.382369932 0.0200264070.556585765

Cd86 27.04826271 5.126443411 48.97008201 9.552447591 3.255870437 0.0202370220.561607303 1810013A23Rik 12.18410276 1.721067948 22.64713757 13.15877017 3.717952755 0.0203264790.563256639 Ctdsp2 2834.009974 2363.746541 3304.273408 1.397896666 0.483257719 0.0204226560.565087066 D18Ertd653e 75.7974955 42.41282519 109.1821658 2.574272412 1.364164729 0.0204741450.565509311 Prrt2 76.16973065 42.99392254 109.3455388 2.543278963 1.346689715 0.0204982050.565509311 Zfp92 550.5799562 673.2625306 427.8973819 0.635557992 -0.653904324 0.0205321770.565614736 Dnm1 260.4040595 193.1442292 327.6638899 1.696472586 0.762538117 0.0205627450.565626233 Morn4 273.7767781 197.6216949 349.9318614 1.770715819 0.824332694 0.0206627960.567546199 Kbtbd11 118.7777534 159.9208859 77.6346208 0.48545642 -1.042586305 0.0208015110.570520973 Zswim4 169.4638673 113.2957581 225.6319766 1.991530666 0.993877695 0.0209530050.572901831

Krt5 32.29617462 61.89147211 2.700877142 0.043638922 -4.518240717 0.020982870.572901831 Fli1 44.88921958 6.48815629 83.29028286 12.8372806 3.682267715 0.0210031260.572901831 Slk 2690.7115 2283.46278 3097.960219 1.356693985 0.440095344 0.0210104720.572901831 Tmeﬀ2 40.15686533 19.48075026 60.8329804 3.122722666 1.642804447 0.0210736480.573790484

Prss53 520.2297238 627.6388537 412.820594 0.65773588 -0.604419721 0.0211457920.574920362

Lix1 26.73611474 9.090397801 44.38183169 4.882276074 2.287553876 0.0213436860.579166038

Slc38a4 3573.29245 4125.890462 3020.694439 0.732131516 -0.449825265 0.0213898670.579166038

Sec11c 695.3234959 834.8375075 555.8094843 0.665769661 -0.586904966 0.0213945660.579166038

Mpped2 379.2238595 285.9353642 472.5123547 1.652514567 0.72466299 0.0215975 0.583562908

Fam135a 3290.342584 3819.814002 2760.871167 0.722776336 -0.468378823 0.0216192020.583562908

Odz2 100.9460634 147.6165146 54.27561221 0.367679811 -1.443478133 0.0217404350.585992188

Tspyl4 1137.515673 1333.767658 941.2636879 0.705717883 -0.502836527 0.0218956390.588136265

Srprb 955.9135976 1126.202102 785.6250935 0.697588019 -0.519552832 0.0219060720.588136265

Pgf 176.533916 126.5917295 226.4761026 1.789027636 0.839175673 0.0219747410.588136265

Chd2 2250.804543 1905.770792 2595.838294 1.36209365 0.445825899 0.0219779950.588136265 Fen1 142.6068851 192.4241254 92.78964481 0.482214195 -1.052253974 0.0220073420.588136265 Six4 314.6148685 238.5550069 390.6747302 1.637671476 0.711645975 0.0220080840.588136265 Dnase1l3 37.71639395 1.833019975 73.59976793 40.15219088 5.327406805 0.0220926070.589396191 Nipa1 164.2602537 213.1766991 115.3438083 0.541071368 -0.886109194 0.0221581910.589396191 C1qc 108.4130491 29.98408994 186.8420082 6.231371655 2.639549766 0.0221603020.589396191 Fam171b 91.7520799 128.2717592 55.2324006 0.430588938 -1.215616838 0.0221809010.589396191 Cd36 84.50013956 29.06776923 139.9325099 4.814009247 2.267238913 0.0223464390.592955025 Cenpf 711.4350538 884.5909259 538.2791817 0.608506334 -0.716655814 0.0224138640.59333062

Rwdd4a 850.5464113 1002.498028 698.5947942 0.696854033 -0.521071602 0.0224238490.59333062

Amigo3 141.9315498 189.8936471 93.9694525 0.494853061 -1.014927893 0.0225195820.593417348

Crim1 123.4259702 44.31220009 202.5397402 4.570744396 2.192429143 0.0225600090.593417348

Lap3 709.2269399 840.1247141 578.3291658 0.688384898 -0.538712647 0.0225798210.593417348

Dusp28 205.1992604 261.6222144 148.7763065 0.568668478 -0.814340258 0.0225830640.593417348

Tmcc2 205.7145489 267.1266744 144.3024235 0.540202224 -0.888428517 0.0226008860.593417348

AI427809 22.35913149 6.774032462 37.94423052 5.60142437 2.485793733 0.022627420.593417348

Thumpd1 868.3367333 1022.924058 713.7494086 0.697754054 -0.519209493 0.0226552060.593417348

Eif1a 2110.621832 2452.451548 1768.792117 0.721234276 -0.471460134 0.0226909790.593417348

Cd300a 33.36228515 9.487314651 57.23725565 6.033030183 2.5928828 0.0227256970.593417348

St8sia1 150.6463374 94.39147931 206.9011956 2.191947802 1.132213443 0.0227434470.593417348 Sord 101.9658529 61.57020354 142.3615023 2.312181771 1.209254819 0.0228132150.59441098 Rab33a 11.88067245 1.801353052 21.95999185 12.19083168 3.607724647 0.0228999230.595176016 Gm648 34.51723486 54.71553798 14.31893173 0.261697724 -1.93402672 0.0229060280.595176016 Fam131a 192.7702501 266.532633 119.0078673 0.446503927 -1.163255232 0.0229399090.595231953 Deb1 460.2834805 556.7704816 363.7964793 0.653404754 -0.613951144 0.022995490.595849998 Atp6v1c1 1385.159146 1609.099953 1161.21834 0.721657059 -0.470614682 0.0231017280.596291266 Gcgr 205.8073443 285.2533076 126.361381 0.442979547 -1.174688005 0.0231276790.596291266 Fgl2 92.70049836 52.98897075 132.412026 2.498860123 1.321270147 0.0231494450.596291266 Tspan5 1024.95756 1204.425393 845.489727 0.701985969 -0.5104859 0.0231631210.596291266

Krt6a 5.940326082 11.88065216 0 0 #NAME? 0.0231742290.596291266 Eif4ebp2 1440.067782 1195.666469 1684.469096 1.408811854 0.494478954 0.0232330460.596291266 Coro2a 128.4941983 83.36869823 173.6196984 2.08255259 1.058352928 0.0232350170.596291266 Itfg1 4033.492341 4711.220849 3355.763834 0.712291769 -0.489459775 0.0233002620.597148789

Sytl5 1153.284182 1430.272389 876.2959755 0.612677684 -0.70679979 0.0235662350.60247408

Mtmr7 1131.861214 1329.804109 933.9183181 0.702297663 -0.50984546 0.023572280.60247408

Mn1 56.60206491 20.38904439 92.81508544 4.552203804 2.186565149 0.0236298420.603123595

Celf4 688.6844024 815.451826 561.9169788 0.689086664 -0.537242657 0.0237356830.60500191

Ppm1h 1121.763736 864.048471 1379.479002 1.596529648 0.674939345 0.0237920440.605216257

Pik3ca 1123.92116 922.5421326 1325.300188 1.436574158 0.522632469 0.0238086140.605216257

Pde6a 8.424184773 16.84836955 0 0 #NAME? 0.0238505580.605462057

1700011H14Rik 118.3656608 74.97192455 161.7593971 2.157599636 1.109427184 0.0239456540.607054697

Stt3a 5391.013952 6228.830431 4553.197473 0.730987546 -0.452081268 0.024038540.608009185

Stard3 175.8796797 123.2465715 228.5127879 1.854110709 0.89072739 0.0240612450.608009185

Ucp2 2479.884406 2022.790729 2936.978084 1.451943615 0.537985429 0.0240805340.608009185 Iﬁtm2 881.6888146 711.7112178 1051.666411 1.477658895 0.563313274 0.0242428760.610816076 Nynrin 1378.82438 1143.199995 1614.448765 1.41221901 0.497963842 0.0242568220.610816076 Gemin6 473.1788502 575.3051131 371.0525873 0.644966608 -0.632703626 0.024517110.61654288 Psmc2 1574.136437 1835.93609 1312.336784 0.714805265 -0.484377834 0.0245969420.6177224 Pfkfb3 215.6425807 112.2374226 319.0477388 2.842614622 1.507218524 0.0246675310.618103047 Vps8 374.0452626 460.6674446 287.4230806 0.623927486 -0.680549729 0.0246779950.618103047 Pde4dip 1973.795288 2288.907689 1658.682886 0.724661328 -0.464621189 0.0248042 0.619719447 Tlr9 10.99347427 1.527889245 20.4590593 13.3904073 3.743127939 0.0248085980.619719447

Enho 191.8089702 248.946585 134.6713555 0.540964864 -0.886393202 0.024994910.623543245

Secisbp2l 972.0953727 794.3882241 1149.802521 1.447406301 0.533469958 0.0250646950.624453766

4930550C14Rik 285.5228129 214.7974427 356.248183 1.65853084 0.729905839 0.0251443850.625608298

Bicc1 724.1088311 589.209786 859.0078762 1.457898183 0.543889968 0.0252792270.628130207

Snx33 189.5831958 133.5807122 245.5856794 1.838481584 0.878514725 0.0254009590.629978891

Ung 361.3145924 442.6487381 279.9804467 0.632511567 -0.660836233 0.025420790.629978891

Gm98 1407.3861 1181.982986 1632.789214 1.381398238 0.466129289 0.0254770170.630253217

C1qb 141.0148241 33.2298916 248.7997565 7.487227449 2.904431582 0.0255118750.630253217

Phc3 1711.089198 1446.846405 1975.33199 1.365267234 0.449183369 0.0255344320.630253217

Dsp 1789.120372 1306.89442 2271.346324 1.737972318 0.797405103 0.0255860530.630253217

Sema4g 257.8668854 194.4078077 321.3259631 1.652844949 0.724951394 0.0255998370.630253217 Gatsl2 4702.356284 5413.498106 3991.214462 0.737270871 -0.439733337 0.0257226110.632445854 Svil 1307.28406 1095.561222 1519.006899 1.386510282 0.471458315 0.0257794670.633014137 Clmn 770.3654843 623.7163798 917.0145888 1.470242916 0.556054539 0.0258622270.633673897 Satb2 27.69673459 45.79595967 9.597509514 0.209571097 -2.254488333 0.025901320.633673897 Ctnnbip1 400.2106089 491.739882 308.6813358 0.627732968 -0.671777114 0.0259076690.633673897 Pnmal1 203.6836747 284.4910568 122.8762927 0.431916188 -1.211176707 0.0260082310.634630367 Hyal2 218.6528353 160.7973551 276.5083154 1.719607361 0.782079191 0.0260144320.634630367 Cldn3 235.9930889 155.6692454 316.3169323 2.031980893 1.022886837 0.0260578570.634864154 Efha2 744.817454 882.9540319 606.6808761 0.68710358 -0.541400495 0.0261025720.635128729

Atg9a 382.5255577 303.6430541 461.4080614 1.519573905 0.603666842 0.0261616980.635309185 Sh3bgrl 930.2616915 749.8146992 1110.708684 1.481310896 0.566874464 0.0261777190.635309185 Tbc1d4 151.3626996 84.73466689 217.9907322 2.572627476 1.363242566 0.0263052290.636937349 Psmd6 1752.439155 2025.947153 1478.931156 0.729994933 -0.454041645 0.026312710.636937349

Npr2 292.6239752 225.9750685 359.272882 1.589878408 0.668916434 0.0264199560.638137486

Apobec3 317.7578808 218.2820748 417.2336867 1.911442738 0.934661981 0.0264382440.638137486

Ccdc114 78.85570652 42.00940835 115.7020047 2.754192674 1.461629489 0.0264643370.638137486

Fank1 45.50880523 23.59735515 67.4202553 2.857110674 1.514556922 0.0265953610.64047365

Pomt2 1168.261414 1369.508787 967.014041 0.706102838 -0.50204978 0.026656880.640865487

Nbeal1 1637.302209 1389.381374 1885.223043 1.356879457 0.44029256 0.0266799540.640865487

Sel1l3 276.4341043 203.3035041 349.5647045 1.71942292 0.781924442 0.0267766290.641595682

Eif3b 1126.239992 1326.087288 926.3926955 0.698591039 -0.517479959 0.0267787540.641595682

Glp1r 2107.550298 1478.762419 2736.338177 1.850424478 0.887856256 0.0268760660.643105857

Angpt2 243.2767797 174.5731984 311.980361 1.787103427 0.837623131 0.026983360.644136428

Zfand5 1169.459339 966.2941531 1372.624525 1.420503809 0.5064027 0.0269878060.644136428 Umps 810.320075 965.9418224 654.6983275 0.677782359 -0.561106006 0.0271267240.646629412 Ndst2 368.6802658 285.9262417 451.4342899 1.578848752 0.658872973 0.0272464160.648658335 Wsb2 1091.866884 1282.075104 901.6586638 0.70328069 -0.507827489 0.0273148130.649462483 Ube3b 1077.036797 887.9035963 1266.169997 1.426021927 0.511996165 0.0273569850.649556741 Zc3h12c 1243.606983 1461.637271 1025.576696 0.701662934 -0.511149942 0.0274390040.649556741 Hist2h3c2 74.64610579 34.69149826 114.6007133 3.303423578 1.723961969 0.0274486590.649556741 Rnase4 2882.161356 2425.872077 3338.450634 1.37618577 0.460675232 0.0274572760.649556741 Btd 183.0276148 128.2081671 237.8470626 1.855163115 0.891546041 0.0275252740.650345261

Slco2b1 82.84183312 16.36530727 149.318359 9.12407916 3.189678963 0.0276857570.653314223

Bub1 224.4468587 286.4964522 162.3972653 0.566838661 -0.818989936 0.0278300130.655165265

Tspan9 456.5155484 366.1092942 546.9218026 1.493875767 0.579060176 0.0278413610.655165265

Stox1 106.4813377 145.602491 67.3601844 0.462630714 -1.112067045 0.0279034060.655165265

4930524O08Rik 5.918324764 11.83664953 0 0 #NAME? 0.0279038940.655165265

Ces1d 87.8351744 120.453333 55.21701582 0.458410029 -1.125289489 0.0279459540.655332618

Parm1 1121.02142 899.5374229 1342.505417 1.492439761 0.577672702 0.0280092280.655621398

Samd1 268.4637271 199.3740229 337.5534312 1.693066259 0.759638435 0.0280617240.655621398

Aldh9a1 1254.862911 1454.268176 1055.457647 0.725765484 -0.462424648 0.0281056890.655621398

Fam101a 94.35559623 144.1798947 44.53129774 0.308859275 -1.69497844 0.0281239670.655621398

1-Mar 15.32517109 3.000612579 27.64972961 9.214694958 3.203936408 0.0281330080.655621398 Mzt1 1010.303952 1212.906011 807.701893 0.665922904 -0.586572934 0.0281693710.655654338 Sec24d 1432.767009 1672.753244 1192.780773 0.713064391 -0.487895735 0.0283255040.657891686 Ppa1 728.4832925 865.8065495 591.1600355 0.682785359 -0.550495973 0.0283680180.657891686 Pdia5 400.3872772 488.7591464 312.0154079 0.63838275 -0.647506427 0.0283772 0.657891686 Mesdc1 235.9329551 172.4906715 299.3752387 1.735602488 0.795436559 0.0284057710.657891686 Chgb 27654.3871 33407.61409 21901.16011 0.655573907 -0.60916966 0.028471080.658591196 Scara3 172.9589459 101.9701724 243.9477194 2.392343895 1.258424789 0.0285786610.659432488 Cldn11 864.2433651 1103.910439 624.5762916 0.565785294 -0.821673418 0.0286150320.659432488 Fam125b 486.3846124 325.9605557 646.8086691 1.984315764 0.98864162 0.0286328360.659432488

Ccdc56 671.9636139 799.4466211 544.4806067 0.681071872 -0.554121044 0.0286754510.659432488 Neu3 75.42076704 39.25025045 111.5912836 2.843071887 1.507450578 0.0286832040.659432488 Sepp1 5198.323122 4434.922732 5961.723512 1.34426773 0.4268205 0.0287899490.660906696 Bank1 11.39299696 1.680925396 21.10506852 12.55562476 3.650261913 0.0288177870.660906696

C3ar1 193.5738743 49.6097862 337.5379623 6.803858435 2.766353124 0.0288976660.661165834

Atp6v0d1 1905.649801 2193.686114 1617.613488 0.737395144 -0.439490179 0.0289001860.661165834

Tbl2 1079.557427 1266.121758 892.993097 0.705297963 -0.503695221 0.0289436720.661165834

Scn9a 611.8629551 729.5438066 494.1821036 0.677385099 -0.561951844 0.0289700590.661165834

Sar1b 1489.985653 1819.788261 1160.183045 0.637537383 -0.649418157 0.0290626130.662018908

Col6a6 988.4777898 478.542695 1498.412885 3.131199996 1.646715659 0.0291406960.662018908

Optn 144.5253942 189.4308516 99.61993667 0.525890771 -0.927164915 0.0291779950.662018908

Rps6ka2 1166.61652 943.5723782 1389.660663 1.472765306 0.558527547 0.0291830220.662018908

2900052N01Rik 5.86358887 0 11.72717774 Inf Inf 0.0292375350.662018908

Col24a1 13.83854876 1.59969872 26.0773988 16.30144381 4.026927844 0.029244380.662018908

Gpd2 3020.988022 3449.183736 2592.792307 0.751711856 -0.411748337 0.029254460.662018908 Vat1l 1391.709657 1637.105429 1146.313885 0.700207735 -0.514145096 0.029458360.665829925 Zfp945 282.5047466 215.5679378 349.4415554 1.6210275 0.696908566 0.0295197930.666412531 Sec11a 2120.60517 2543.598835 1697.611505 0.667405363 -0.583364814 0.0295551830.666412531 Rab33b 930.7036085 1086.802368 774.6048492 0.712737543 -0.488557176 0.0296198060.667067892 Fbrs 1133.257323 937.5669562 1328.947689 1.417442968 0.503290688 0.029765670.668909312 Lima1 849.8769819 676.130066 1023.623898 1.513945244 0.598313027 0.0297728820.668909312 Gng2 348.7390063 190.5140607 506.9639518 2.661031684 1.411985688 0.0300576310.674326971 Txndc15 437.1090994 345.1267557 529.0914431 1.533035137 0.616390763 0.030085910.674326971

Bcmo1 84.34600296 119.2082746 49.48373134 0.415103159 -1.268458184 0.0301447560.674703147

Ipp 608.5984274 720.7021945 496.4946602 0.688904049 -0.537625037 0.0301746240.674703147

Slco3a1 589.9441616 701.2829562 478.6053669 0.682471123 -0.551160091 0.0302412330.675387526

Ctif 991.4136784 1197.231212 785.5961452 0.656177468 -0.60784204 0.0303349590.676675182

1110003E01Rik 1813.794476 2241.350669 1386.238284 0.618483445 -0.693193116 0.0303711760.676678449

Trim30a 34.03876038 7.579777407 60.49774336 7.981467015 2.996653942 0.0305032460.678814814

Atm 1930.64281 2254.963124 1606.322495 0.712349784 -0.489342275 0.030597790.680112022

Gmnn 148.4166492 205.2245221 91.60877629 0.446383187 -1.163645405 0.0306882920.681316395

Dnajc10 2325.290305 2680.340097 1970.240514 0.735071089 -0.444044315 0.0307333560.681510348

Fzd8 46.76805448 23.25050625 70.28560271 3.022970853 1.595967069 0.0309438940.684975854

Kcna2 44.75325785 70.38581444 19.12070125 0.271655608 -1.880149263 0.0309797220.684975854 Crot 683.1771133 803.3444232 563.0098034 0.700832404 -0.512858613 0.0309991740.684975854 Ptprr 166.6898218 215.3779244 118.0017193 0.547882146 -0.868062505 0.0311385410.686616792 Tdrd9 32.26847573 11.49727985 53.03967161 4.61323655 2.20577927 0.0311933470.686616792 Cmbl 87.63535049 121.945906 53.32479499 0.437282372 -1.193362905 0.0312276730.686616792 Agpat5 742.5153192 884.8526609 600.1779774 0.67828013 -0.560046866 0.0312852520.686616792 Sytl4 8221.498995 9257.274766 7185.723224 0.776224473 -0.365454176 0.0313078810.686616792 C5ar1 55.52522395 5.46515889 105.585289 19.31971076 4.27200159 0.0313080210.686616792 Zp2 45.77462866 70.73499163 20.81426569 0.29425699 -1.764851411 0.0313296360.686616792 Cep110 597.2602429 481.1446867 713.3757991 1.482663778 0.568191477 0.0314156120.687147804

Atad1 3483.765008 3976.17465 2991.355366 0.752319913 -0.410581818 0.031434970.687147804 Asf1b 64.6744965 93.45725284 35.89174017 0.38404446 -1.380654758 0.0314637510.687147804 Rusc2 159.2717938 113.6279029 204.9156847 1.803392296 0.850713263 0.0315928840.689065838 Cerkl 946.9465183 781.7917676 1112.101269 1.422503172 0.508431869 0.0316390470.689065838

Casc4 3645.418801 4152.359078 3138.478524 0.755830232 -0.40386587 0.0316617670.689065838

Nuak1 136.1988012 179.2193216 93.17828068 0.519912026 -0.943660567 0.0317966320.691128155

Tmem41b 509.8662866 608.8648487 410.8677244 0.674809402 -0.567448021 0.0318302090.691128155

Zfp608 853.6655461 644.9041507 1062.426942 1.647418365 0.720206977 0.0318865250.691550534

Ncald 401.0086152 487.1229716 314.8942587 0.64643689 -0.629418565 0.0320424540.693047318

Sec22b 1860.771356 2134.936536 1586.606176 0.743163157 -0.428249115 0.0320528420.693047318

Actn1 604.2799369 489.5072203 719.0526535 1.46893166 0.554767278 0.0320663680.693047318

Pa2g4 1793.507205 2072.747908 1514.266502 0.730559899 -0.45292553 0.0321199710.69340697

Nceh1 246.0531237 306.2307388 185.8755085 0.606978611 -0.720282416 0.0321924980.694173866

Mtap4 1861.809611 1518.038402 2205.580819 1.452915035 0.538950338 0.0322297490.694179215

Dmd 846.7840313 997.9543513 695.6137113 0.697039609 -0.520687455 0.0323163660.694251832 Mal 35.38076687 55.39649244 15.3650413 0.277364877 -1.850142987 0.0323394320.694251832 Slc25a5 2988.793835 3421.490348 2556.097322 0.747071323 -0.42068211 0.0323441420.694251832 Diap2 418.2929416 331.4202358 505.1656474 1.52424503 0.608094842 0.0324719370.69619832 Cdh23 90.69924118 48.99095118 132.4075312 2.70269362 1.434397976 0.0325644880.697385611 Plaa 1476.505185 1704.215596 1248.794774 0.732768071 -0.448571454 0.0327597630.70076757 Ndst4 295.1186713 373.1872255 217.0501171 0.581611862 -0.781871401 0.0329176380.702822562 Mcm5 281.0526071 357.3771252 204.7280891 0.57286288 -0.803738238 0.0330014990.702822562 Ghr 2899.764824 3342.8608 2456.668849 0.734900134 -0.444379881 0.033034390.702822562

Ighmbp2 121.9941488 83.92876194 160.0595357 1.907088011 0.931371425 0.0330421380.702822562

Gna12 360.7917697 286.393666 435.1898733 1.51955132 0.6036454 0.033043150.702822562

Ap1m2 473.1482437 571.6162548 374.6802327 0.655475119 -0.609387076 0.0332202520.704427592

Bmp2 58.58626262 29.75306191 87.41946333 2.938166955 1.554916376 0.0332524360.704427592

Zfp930 186.3841757 134.2852583 238.4830932 1.775943958 0.828586056 0.0332580810.704427592

Cldn4 176.2186141 242.3312606 110.1059676 0.454361387 -1.13808786 0.0332688080.704427592

Frmd4b 300.6600345 373.9649404 227.3551286 0.607958405 -0.717955474 0.033334850.705030204

Tubg1 252.5194979 313.498386 191.5406098 0.610977978 -0.710807715 0.0333878790.705356553

Psmg1 458.7957918 548.4722936 369.11929 0.672995326 -0.57133161 0.0335258380.707465168

Clec4e 14.8106978 0 29.6213956 Inf Inf 0.0336241860.707465168

Syvn1 1305.433003 1540.396205 1070.4698 0.694931471 -0.525057379 0.0336498130.707465168 Spcs2 4515.066624 5554.602906 3475.530342 0.625702755 -0.676450638 0.0336725250.707465168 Kctd1 276.3877666 198.5993929 354.1761402 1.783369702 0.834605812 0.0337594650.707465168 Rab26 88.52801223 56.76432021 120.2917043 2.119142867 1.083480854 0.0337792190.707465168 Tspan8 583.6829088 843.5559668 323.8098508 0.383862913 -1.381336914 0.0338112730.707465168 Iars2 682.7206043 807.7817156 557.659493 0.690359143 -0.534581009 0.0338245860.707465168 Ccdc106 23.06154134 8.283257752 37.83982494 4.568229804 2.191635227 0.0338270930.707465168 Ky 226.2664923 153.335026 299.1979585 1.951269493 0.964413044 0.0338877490.707944519 4932425I24Rik 84.31086768 54.27815244 114.3435829 2.106622606 1.074931883 0.0339507650.7082743 Scd2 11572.96039 8845.919925 14300.00086 1.616564583 0.692931146 0.0339790440.7082743

Rab3il1 42.43565739 18.45313862 66.41817615 3.599288853 1.847711887 0.0341532260.711114894 Rhobtb2 211.4435262 269.1094608 153.7775915 0.571431383 -0.807347823 0.0341968230.711145811 C230081A13Rik 402.975849 264.186834 541.764864 2.050688355 1.036108261 0.0342340130.711145811 Tmem151a 31.87891299 12.91470596 50.84312002 3.936839147 1.977037768 0.0342684340.711145811

Cope 1638.785933 1891.58901 1385.982856 0.732708241 -0.448689253 0.0343564970.712185516

Calr 7852.182844 8929.962466 6774.403222 0.758614972 -0.398560251 0.034460130.713014626

Pik3cd 36.54981548 16.49173101 56.60789994 3.432502015 1.779260567 0.0344725090.713014626

Ttc30b 264.4924214 202.1176926 326.8671502 1.617211962 0.69350878 0.0345380660.713494621

Mknk2 410.28663 318.3210519 502.2522081 1.5778165 0.65792943 0.0345717810.713494621

Cmklr1 33.2756207 6.366776988 60.18446442 9.452893439 3.240755992 0.034819170.717619787

Ttr 44424.99809 50076.77243 38773.22376 0.774275615 -0.369080889 0.0348733620.717619787

H47 1841.142358 2186.959128 1495.325587 0.683746471 -0.548466612 0.034886420.717619787

Pmepa1 368.9092291 290.8770282 446.94143 1.536530515 0.619676419 0.0350592710.71865974

Grtp1 227.9888861 289.3622198 166.6155524 0.575802717 -0.796353498 0.0350629380.71865974

Gtf2h3 571.4333216 677.2638679 465.6027753 0.687476178 -0.540618372 0.0350694730.71865974 Hepacam2 2052.054448 2467.936173 1636.172724 0.662972058 -0.592980028 0.0351054250.71865974 Cyb5r1 230.5281907 168.4622061 292.5941753 1.736853518 0.796476086 0.0351772540.71865974 Lmbrd1 718.6913154 587.1356835 850.2469472 1.448126849 0.534187981 0.0351786920.71865974 Mki67 2991.334902 3527.269417 2455.400387 0.69611932 -0.52259348 0.0352051330.71865974 Gm14085 541.7084235 428.4660495 654.9507975 1.528594385 0.612205636 0.0352961790.719735131 Rph3a 14.69937234 3.648464887 25.7502798 7.057839555 2.819226634 0.0354072320.720702145 Akt3 2441.509484 2817.008732 2066.010236 0.733405691 -0.447316633 0.0354802810.720702145 Trim35 6387.62053 7236.880495 5538.360566 0.765296673 -0.385908967 0.0355790130.720702145

Pcyt1b 1526.151022 1198.002597 1854.299447 1.547825899 0.630243205 0.0355808450.720702145

Casp1 18.55475016 0.65793807 36.45156225 55.40272547 5.791885044 0.0356007760.720702145

Nfkbiz 1058.632197 644.1901696 1473.074225 2.286707085 1.193271576 0.035617230.720702145

Clptm1l 1657.159793 2011.137289 1303.182297 0.647982763 -0.625972659 0.035627470.720702145

F3 676.5725652 540.0558131 813.0893174 1.505565347 0.590305327 0.0356850540.720702145

Nrsn1 142.4838592 97.27366477 187.6940537 1.929546442 0.948261768 0.0357305180.720702145

Slfn4 5.572217608 0 11.14443522 Inf Inf 0.0357339080.720702145

Gm5480 495.6162157 599.0790416 392.1533898 0.654593739 -0.611328292 0.0357661890.720702145

Ccl24 20.85371041 3.08650384 38.62091699 12.5128362 3.645336928 0.0358375430.721365132

Gpr97 48.04752186 26.07085077 70.02419295 2.685918981 1.425415787 0.0358943750.72173471

Pld6 29.3625033 10.0434588 48.68154781 4.847089911 2.277118844 0.0359786310.72265431 Ltbp3 769.0826204 626.3916666 911.7735743 1.455596591 0.541610577 0.0362021030.725293864 Gdap2 414.4990679 497.0299851 331.9681506 0.667903669 -0.582288055 0.0363177520.725293864 Glrx5 416.0771565 503.6979904 328.4563227 0.652089802 -0.616857438 0.0363235240.725293864 D16Ertd472e 323.6324216 210.584238 436.6806051 2.073662347 1.052181 0.0363496920.725293864 Igsf11 418.5532424 503.9355686 333.1709161 0.661137925 -0.596976821 0.0363568930.725293864 Gad1 112.9916895 167.3845043 58.59887467 0.350085421 -1.514221111 0.0363629650.725293864 Cmah 20.33231991 1.030418819 39.634221 38.4641859 5.265443869 0.0363806780.725293864 Vgf 43.24458254 65.77341914 20.71574593 0.314956197 -1.666776899 0.0365536420.727346466 Ica1 1269.8496 1485.309633 1054.389568 0.70987863 -0.494355711 0.0365611790.727346466

Cd163 38.44023496 2.907211869 73.97325805 25.44474272 4.669295699 0.0366530810.728052041 Ppﬁbp2 23.49975771 6.053170628 40.94634479 6.764445826 2.757971747 0.0366900610.728052041 Slc24a2 521.3160785 622.415608 420.216549 0.675138193 -0.566745259 0.036722570.728052041 Praf2 162.540666 114.9633727 210.1179594 1.827694808 0.870025186 0.0367518810.728052041

Rgs11 399.2344368 313.4442304 485.0246432 1.547403321 0.629849276 0.0368498850.728589855

Ffar1 89.16917993 120.8499658 57.48839409 0.475700541 -1.071874429 0.0368567040.728589855

Lgi1 29.63676301 10.51208832 48.7614377 4.638606165 2.213691361 0.0369195250.72899355

Pkd2l1 5.649805783 0 11.29961157 Inf Inf 0.0370248090.72899355

Bmp3 155.5465615 109.2943197 201.7988033 1.846379608 0.884699196 0.0370645360.72899355

Bex2 2412.31015 2755.280683 2069.339618 0.751044941 -0.413028857 0.0370684870.72899355

4930402H24Rik 920.8616099 764.4252378 1077.297982 1.409291489 0.494970041 0.037071420.72899355

Stx2 145.7662739 103.8869307 187.6456172 1.806248544 0.852996424 0.0373108350.730865326

2700049A03Rik 771.6880387 910.654886 632.7211915 0.694797998 -0.525334498 0.0373301030.730865326

Rars 1356.446049 1575.623935 1137.268164 0.721789089 -0.470350761 0.037373450.730865326

Tmc7 80.89126742 112.8344572 48.94807764 0.433804344 -1.204883596 0.0373889730.730865326 Pcsk6 156.1720433 206.0567992 106.2872875 0.515815483 -0.955073015 0.0373981090.730865326 Racgap1 347.5591562 428.751478 266.3668344 0.621261612 -0.686727182 0.0374003580.730865326 Rab2a 7829.689832 9003.43562 6655.944045 0.739267134 -0.435832319 0.0375055530.731906416 Dusp4 124.1435935 165.7262988 82.56088825 0.498176143 -1.005272162 0.0375316620.731906416 Cst7 5.861109612 0 11.72221922 Inf Inf 0.0377057720.734081303 2210404O07Rik 331.6999957 253.6163215 409.7836699 1.615762217 0.6922149 0.0377214490.734081303 Mospd1 83.41353953 52.74437676 114.0827023 2.162935829 1.112990864 0.0378191570.734548192 Inppl1 862.8157108 693.8362909 1031.795131 1.487087292 0.572489336 0.0378813320.734548192

Ppp1r16b 26.05098972 4.868080918 47.23389852 9.702775963 3.278397561 0.0378888930.734548192

Poc1b 542.6269961 443.3309776 641.9230145 1.447954343 0.534016112 0.0379427950.734548192

Ralyl 18.44795615 1.881638156 35.01427415 18.6083993 4.217882055 0.0379907310.734548192

Ablim1 601.4304261 483.284976 719.5758761 1.488926641 0.574272675 0.0379910110.734548192

Tcam1 6.530540908 12.82855622 0.23252559 0.018125624 -5.785825503 0.0380195250.734548192

2700081O15Rik 829.3619428 664.236153 994.4877325 1.49719001 0.582257327 0.0380832610.735022617

Cpn1 497.7403606 593.3758923 402.1048289 0.67765616 -0.561374652 0.0381450350.735458233

Csnk1e 914.6266251 648.6816461 1180.571604 1.819955307 0.863903022 0.0381876280.735523515

0610009B22Rik 1204.993528 1415.588229 994.3988269 0.702463334 -0.509505171 0.0382734820.735850655

Kcnj12 16.28471114 3.574386618 28.99503565 8.111891284 3.020038317 0.0382830620.735850655

Smad3 567.3184435 462.5057763 672.1311107 1.453238306 0.539271299 0.0383342670.736080697 4930404A10Rik 17.37377099 34.2824908 0.465051181 0.013565268 -6.203938623 0.0385325680.7384556 Dusp16 672.6293147 552.9660041 792.2926253 1.432805307 0.518842586 0.0385366760.7384556 Slc39a7 1453.143505 1667.839808 1238.447203 0.742545655 -0.429448363 0.0385973540.738819024 Rdh13 530.9371379 631.8069345 430.0673414 0.68069424 -0.554921192 0.0386493090.738819024 Ccnl1 1562.984697 1329.103254 1796.86614 1.351938711 0.43502975 0.0386737890.738819024 Nudt12 101.8929782 65.72933985 138.0566165 2.10038039 1.070650631 0.0388119250.739871417 Tmem39a 1829.061732 2120.976336 1537.147129 0.724735634 -0.464473265 0.0389307380.739871417 Slc30a8 7953.613328 9108.608723 6798.617933 0.746394772 -0.421989213 0.0389692460.739871417 Eif2s1 1595.572549 1838.860953 1352.284145 0.735392278 -0.443414068 0.0389883370.739871417

Ppp3cc 201.4763919 149.7025695 253.2502143 1.691689161 0.758464505 0.0389913430.739871417 Fam83b 124.302796 164.503387 84.10220508 0.511249079 -0.967901756 0.0390046550.739871417 Nkg7 7.350022337 0.313606359 14.38643831 45.87419191 5.51961084 0.0390291360.739871417 Slc30a5 1225.968092 1421.685936 1030.250248 0.724667961 -0.464607984 0.0390443870.739871417

Osmr 29.02336227 4.807401341 53.23932319 11.07444946 3.469163075 0.0391959030.741993069

Dcdc2a 1029.708858 853.0348478 1206.382869 1.414224603 0.500011263 0.0393137740.742857852

Fermt3 47.98228436 20.48859282 75.4759759 3.683804766 1.881196604 0.0393390310.742857852

Rasa4 37.15379742 17.94468283 56.362912 3.140925506 1.651189727 0.0393816150.742857852

Ncoa3 972.9140775 815.4781886 1130.349966 1.38611919 0.471051318 0.0394951130.742857852

Usp11 1060.413715 891.2218005 1229.60563 1.379685314 0.464339247 0.0395056960.742857852

Rian 8959.924034 10231.94151 7687.906557 0.751363419 -0.412417216 0.039556620.742857852

Bri3 127.8213183 89.09919496 166.5434416 1.869191317 0.902414241 0.0396111560.742857852

Vwa2 51.31921934 28.58836208 74.05007659 2.590217529 1.373073262 0.0396118150.742857852

Ppp2r2b 652.4886809 541.1080022 763.8693595 1.411676331 0.497409346 0.0396122580.742857852

Car10 208.3542912 152.3965968 264.3119857 1.734369344 0.794411162 0.0396412610.742857852 Col9a2 334.4833583 253.7043273 415.2623894 1.636796636 0.710875085 0.0397104560.742857852 Ppp2r3a 1835.92488 1563.296273 2108.553487 1.34878687 0.431662398 0.039716760.742857852 Pnrc1 1134.14316 952.9689407 1315.31738 1.380231111 0.464909857 0.0398330950.744291691 Fam69a 99.05560409 51.53270915 146.578499 2.8443779 1.508113152 0.0398876320.744569128 Tsc22d2 594.5429186 487.2777357 701.8081016 1.440263017 0.526332297 0.0401253870.748262679 Krt80 44.24384848 23.31803679 65.16966018 2.794817625 1.482754143 0.0402480070.749803975 Tanc2 949.9436863 791.7262304 1108.161142 1.399677186 0.48509413 0.040393250.751203446 Zfp217 749.1478799 616.6604456 881.6353141 1.429693311 0.515705702 0.0404032130.751203446

Cdc42bpb 1056.614324 887.9252051 1225.303443 1.379962451 0.464629012 0.0405047690.751530574

Chmp1b 460.7862338 371.1398874 550.4325803 1.483086564 0.568602807 0.0405233880.751530574

Acot5 10.54121289 21.08242577 0 0 #NAME? 0.0405409880.751530574

2900064A13Rik 1241.662923 1431.571087 1051.75476 0.734685668 -0.444800964 0.0406749320.752555443

Mllt1 314.7000692 247.3195723 382.0805661 1.544886086 0.627500464 0.0406765040.752555443

Inpp5d 43.62544583 18.57540469 68.67548696 3.697119287 1.886401593 0.0407954570.754012584

Sirt4 106.2662457 72.56547591 139.9670154 1.928837559 0.947731649 0.0409596840.756302818

Pycr2 647.9359274 770.1721492 525.6997057 0.682574287 -0.550942027 0.0410597560.757260545

2610034B18Rik 333.8810985 406.3206827 261.4415144 0.643436393 -0.636130558 0.0410922830.757260545

Csrp2bp 513.2824632 421.3885868 605.1763396 1.436147913 0.522204344 0.0411519720.757616277

Krt14 32.43570619 60.7956211 4.075791281 0.067040869 -3.898815336 0.0412497210.758671335 Cited4 57.91318618 32.49640966 83.32996269 2.564282133 1.358555002 0.0413139940.758828927 Cdh22 23.82242369 40.19535125 7.449496121 0.185332281 -2.431813907 0.0413572740.758828927 Acan 21.59344963 35.66408368 7.522815581 0.210935339 -2.245127278 0.0413796370.758828927 Lcor 1247.336603 1440.881005 1053.792201 0.731352691 -0.451360789 0.0414889260.760090098 Mvd 201.3412866 256.6701274 146.0124459 0.568871989 -0.813824049 0.0415842050.760548165 2010317E24Rik 77.87396601 112.9995257 42.74840634 0.378306069 -1.402374174 0.0415950120.760548165 Rpl36al 1232.394172 1431.049074 1033.739269 0.722364653 -0.469200794 0.0417056550.761828704 Gcsh 1587.235599 1980.938253 1193.532946 0.602508909 -0.730945521 0.0418406120.763333372 Slc44a2 421.2197305 297.5678749 544.871586 1.831083366 0.872697476 0.0418694050.763333372

Tmx1 3152.478644 3553.338837 2751.61845 0.774375475 -0.368894832 0.0419433140.763534423 Pcdh1 471.6448655 377.4918747 565.7978562 1.498834529 0.583841119 0.0419961350.763534423 Krt16 5.054626669 10.10925334 0 0 #NAME? 0.0420127590.763534423 Galnt14 109.8804813 70.78644456 148.974518 2.1045628 1.07352056 0.0420432330.763534423

Klhl18 156.1538986 114.3940471 197.9137502 1.730105327 0.79085987 0.0422204180.766010687

Gm11818 148.4323576 191.3099175 105.5547977 0.551747652 -0.85791951 0.0422734880.766232491

Aga 534.7322647 641.5913021 427.8732274 0.666893747 -0.584471173 0.0424156650.768067455

Cx3cr1 185.1372565 59.45875625 310.8157568 5.227417734 2.386098453 0.042598060.768821158

Acly 8219.465564 9288.032454 7150.898673 0.769904574 -0.377248453 0.0426031530.768821158

Slc29a4 463.3277154 601.7112035 324.9442273 0.540033533 -0.888879101 0.0426430770.768821158

Atp2b2 296.2446147 358.8633356 233.6258939 0.651016336 -0.619234349 0.042668750.768821158

Lfng 48.30948629 25.84552701 70.77344558 2.738324723 1.453293538 0.0427010180.768821158

Ammecr1 160.7517406 113.9572732 207.5462081 1.821263376 0.864939568 0.0427031790.768821158

Foxk1 1665.266584 1428.799027 1901.734142 1.331001846 0.412512572 0.0427762380.769083719

A330049M08Rik 34.63487536 16.21273339 53.05701733 3.272552262 1.710416232 0.0427997550.769083719 Zdhhc2 881.892147 1028.606623 735.1776706 0.714731613 -0.484526495 0.0428468160.769192594 Peg3 39259.61945 34287.66321 44231.5757 1.290014295 0.367387053 0.0429246960.769854018 Csad 275.4481214 215.6780054 335.2182375 1.554253235 0.636221582 0.0430123080.770688538 Gins2 185.8790061 237.2423132 134.515699 0.566997081 -0.818586788 0.0432871190.774872466 Tmed8 4445.43288 5025.357445 3865.508314 0.76920067 -0.378568075 0.0433951890.776066484 Pabpn1l 7.540007022 14.6017444 0.478269644 0.032754281 -4.932172696 0.0435117070.776233635 Srxn1 388.7362121 479.3847982 298.0876261 0.621812847 -0.685447671 0.043515130.776233635 Nfatc2 1256.801909 1023.73776 1489.866057 1.45532002 0.541336431 0.0435286670.776233635

Insm1 2514.964554 2931.926649 2098.00246 0.715571264 -0.482832641 0.0435879990.776553532

Vta1 504.9017756 597.4315875 412.3719637 0.690241314 -0.534827268 0.0436470710.776868178

Pappa2 2683.968982 2134.554965 3233.382999 1.514780857 0.599109094 0.0437020780.777099404

Ints2 876.4504243 735.525401 1017.375448 1.383195531 0.468005113 0.0437429090.777099404

4930406D18Rik 5.094854445 10.18970889 0 0 #NAME? 0.0438930380.778832778

Pkp1 5.005208459 10.01041692 0 0 #NAME? 0.0439235120.778832778

Ntm 110.4401825 72.86796937 148.0123957 2.031240845 1.022361311 0.0440424490.780204297

Slc44a3 1030.410708 1199.004871 861.816545 0.718776517 -0.476384819 0.0441139380.780733477

Enpp3 46.99553938 69.62359301 24.36748574 0.349988915 -1.514618868 0.0441713360.780818673

Vgll4 126.6244163 85.59951882 167.6493138 1.95853103 0.969771986 0.0442409150.780818673

Bcl2l13 1071.031177 1239.765648 902.2967056 0.727796183 -0.458393611 0.0442782120.780818673 Mbl2 5.277027452 10.5540549 0 0 #NAME? 0.0442852380.780818673 D0H4S114 13348.84764 10703.14836 15994.54691 1.494377764 0.579544893 0.044400350.781647822 Ech1 373.1141906 291.9472613 454.2811199 1.556038299 0.63787757 0.0444155960.781647822 Lrrk1 114.5256081 77.86130718 151.189909 1.941784879 0.957383381 0.0444968190.78215575 Krba1 321.825392 251.3988851 392.2518989 1.560277003 0.64180218 0.0445278430.78215575 1700019E19Rik 119.722563 84.44366738 155.0014585 1.835560479 0.87622065 0.0445727470.782212094 Abcd4 49.88572939 28.90964834 70.86181044 2.451147437 1.293457265 0.0448603750.786523964 Tcf7l2 891.2505636 737.9776959 1044.523431 1.415386179 0.501195737 0.0449601350.787298763 A430078G23Rik 6.76462901 0.313606359 13.21565166 42.14089181 5.397148941 0.0449969260.787298763

Tbkbp1 20.46956688 6.874967229 34.06416653 4.954811477 2.308830166 0.0450377930.787298763 2010107G23Rik 1055.549762 1271.534681 839.5648424 0.660276794 -0.598857154 0.0451092780.787298763 Ndufb6 432.6986425 514.2445811 351.152704 0.68285154 -0.550356142 0.0451375850.787298763 Nkx2-2 4110.947198 4656.898155 3564.996241 0.765530214 -0.385468776 0.0451563680.787298763

Tbcb 870.3526308 1009.141161 731.5641006 0.724937332 -0.46407181 0.0452753370.788640045

Sh3gl2 512.3783054 616.5508005 408.2058103 0.662079767 -0.594923052 0.0453692360.788914713

Dusp6 191.7290358 137.2500189 246.2080527 1.793865347 0.843071601 0.0453752120.788914713

Dgkq 178.3810438 130.7242965 226.0377912 1.729118437 0.790036691 0.0454671850.789202841

Fut10 87.39682232 57.74521395 117.0484307 2.026980639 1.019332309 0.0455055250.789202841

Irak3 41.96449975 21.48778372 62.44121578 2.905893721 1.538981939 0.0455179890.789202841

Dcaf12 702.1304385 559.5714554 844.6894215 1.509529146 0.594098613 0.0455935140.789782388

Slc25a27 345.2222919 277.6034038 412.8411799 1.487161808 0.572561626 0.0458151670.792889789

Mxi1 703.9099038 574.9976318 832.8221758 1.448392358 0.53445247 0.045957840.794625882

Cyba 58.56334102 33.63516582 83.49151621 2.482268607 1.311659238 0.0460092490.794782239

Bhlhb9 954.5751869 1094.942596 814.2077781 0.74360773 -0.427386327 0.0461201290.794948244 Ahcyl1 4825.904332 5442.932387 4208.876277 0.773273665 -0.370949014 0.0461225440.794948244 Luzp2 24.19572184 40.13927813 8.252165544 0.20558829 -2.282170003 0.0461839150.794948244 Zfp85-rs1 38.74607024 19.3521545 58.13998599 3.004315928 1.587036532 0.0461883570.794948244 Alox5ap 70.80199842 40.14315013 101.4608467 2.527475955 1.337697367 0.0464350790.798462041 Mycn 82.84560654 51.98224449 113.7089686 2.187457846 1.129255216 0.0464995210.798837933 Tcf7l1 98.10444394 66.97698223 129.2319056 1.929497289 0.948225017 0.0465610020.799162307 Zc3h4 1132.849727 978.6830427 1287.01641 1.315049259 0.395116841 0.0467082660.800957098 Gm6377 7.358325609 0.627212719 14.0894385 22.46357269 4.489515493 0.0468033610.801854839

Cd244 5.12635671 0 10.25271342 Inf Inf 0.0468694570.80225457

Pik3cg 119.9326639 56.07938278 183.7859451 3.277246217 1.712484066 0.047106820.805582449

Pfdn4 315.5340745 383.3096107 247.7585382 0.646366622 -0.629575395 0.0471808260.805591041

5830403M04Rik 19.19580891 33.73800671 4.653611106 0.137933789 -2.857952182 0.0471932070.805591041

Ddx19b 767.6618505 905.4008911 629.92281 0.69573911 -0.523381673 0.0474011240.808287966

Ap4s1 267.7647187 326.3531906 209.1762469 0.640950519 -0.641715109 0.0474373690.808287966

Dock1 584.2655745 408.0593939 760.4717551 1.863630066 0.898115511 0.0475878340.810115941

Mov10 623.636057 520.0453463 727.2267677 1.398391069 0.483767876 0.0476395590.81026122

Tmcc1 622.9471711 516.5191587 729.3751836 1.412097056 0.497839252 0.0477422610.811272476

Gimap5 5.08417144 0 10.16834288 Inf Inf 0.047787050.811298689

Galnt12 253.4846715 313.6437395 193.3256034 0.616385979 -0.69809405 0.0479278690.812642556 Cacna2d3 45.27331526 20.84018427 69.70644625 3.344809496 1.741924044 0.0479760410.812642556 Zfp326 864.8514171 1004.266008 725.4368264 0.722355253 -0.469219568 0.0479961590.812642556 Lefty1 41.75637779 21.34954565 62.16320992 2.911687721 1.541855635 0.0480435650.812711706 Sfxn3 408.0387657 326.2211035 489.8564279 1.501608641 0.586508857 0.0481020430.812967858 Edc4 454.623277 368.9774119 540.2691422 1.464233649 0.550145784 0.0483710190.814517194 Zdhhc15 120.4429071 52.67678129 188.2090329 3.572903056 1.83709677 0.0483793170.814517194 Osbpl3 497.5947168 399.9997081 595.1897255 1.487975399 0.573350675 0.0484233230.814517194 Olfm2 32.75753565 12.76571919 52.74935211 4.132109702 2.046878556 0.0484831130.814517194 Bmp2k 222.3428916 150.090469 294.5953142 1.962784953 0.972902117 0.0485068010.814517194

Slc38a10 1295.394259 1491.976127 1098.812391 0.736481215 -0.441279367 0.0485545070.814517194 Zyx 472.3162816 313.1056184 631.5269449 2.016977364 1.012194893 0.0486110550.814517194 Lrrc36 93.09527238 64.06504533 122.1254994 1.906273519 0.930755137 0.0486401880.814517194 Cd3e 12.53051582 2.740254304 22.32077733 8.145513098 3.026005579 0.0486501720.814517194

Ceacam10 16.1093923 5.130595349 27.08818926 5.279736058 2.400465809 0.048785110.814517194

H2-T24 77.82941678 108.8292357 46.82959783 0.430303471 -1.216573619 0.0488410950.814517194

Gtf2e2 1250.808348 1431.461755 1070.154941 0.747595901 -0.419669436 0.048851230.814517194

Ptpn1 606.811795 502.6101679 711.0134221 1.414641938 0.500436937 0.0488771570.814517194

15-Sep 2777.898358 3152.136353 2403.660362 0.762549615 -0.391096886 0.0488990190.814517194

Orc2 504.1493022 591.2812146 417.0173897 0.705277589 -0.503736897 0.0489086450.814517194

Rap1b 6350.541234 7568.022865 5133.059603 0.678256355 -0.560097435 0.0489356910.814517194

Polr1a 666.3364682 559.4440421 773.2288943 1.382138044 0.466901716 0.0489464530.814517194

Mybl1 49.73496689 74.08116075 25.38877302 0.342715648 -1.544916029 0.0489846310.814517194

Rora 146.0452141 102.6800906 189.4103375 1.84466469 0.883358597 0.0490186520.814517194

Il1rl1 45.84792297 1.568031797 90.12781414 57.47830773 5.844945682 0.0491013820.814534671 Copb2 5034.247579 5679.0292 4389.465958 0.772925407 -0.371598904 0.0491065410.814534671 Pard3b 288.4679536 222.3162512 354.619656 1.595113511 0.673659092 0.0491974030.815212263 Tex264 208.4483966 155.7126525 261.1841407 1.677346937 0.746181122 0.0492343010.815212263 Cdk5rap3 652.6088289 774.6376888 530.5799691 0.684939523 -0.545951485 0.0493502320.816411251 Nr1d1 209.0172175 159.2783835 258.7560516 1.624552221 0.700042119 0.0495613590.818902208 Grid1 31.05704593 13.98927195 48.12481991 3.440123265 1.78246026 0.0496180720.818902208 Neu1 468.3578971 553.2471716 383.4686226 0.693123512 -0.528815637 0.0496663450.818902208 Abca4 48.57663537 75.52803968 21.62523106 0.286320566 -1.804296795 0.0496823530.818902208

Atrn 1626.20102 1391.674515 1860.727525 1.337042178 0.419044977 0.0497190630.818902208

Trp53 783.7760574 650.7887955 916.7633193 1.40869561 0.494359909 0.0499177980.82097677

Supplementary Table 3: PANTHER gene ontology categories with significant enrichment of genes downregulated (adjusted pvalue ≤ 0.05) in murine Neurod1ΔEndo compared to Control sorted E17 Neurog3Cre+ RosaTomato+ endocrine cells.

Adjusted Gene Ontology Category # of genes p value regulation of insulin secretion 9 0.0153 regulation of hormone secretion 13 1.06E-04 regulation of hormone levels 18 1.02E-05 endoplasmic reticulum (ER) unfolded protein response 10 1.72E-05 ER associated degradation (ERAD) pathway 7 0.0051 negative regulation of response to ER stress 5 0.0374

Supplemental Table 4. Gene expression changes in 12 week Neurod1 betaCKO vs. control cells

Gene baseMean_all baseMean_Control baseMean_NDbetaCKO foldChange log2FoldChange pval padj

Lrrc55 1951.378627 36.15453612 3866.602718 106.9465448 6.740746063 1.83E-245 3.56E-241

Ins1 423335.1679 776921.604 69748.73184 0.089775766 -3.477530138 2.23E-169 2.17E-165

Car8 5654.742212 740.295338 10569.18909 14.27698993 3.835619938 1.04E-89 5.05E-86

Scg2 233241.3763 76151.30075 390331.4518 5.125735844 2.357759131 2.09E-87 8.14E-84 Ldha 999.9787479 319.2078985 1680.749597 5.265375966 2.396536548 4.88E-76 1.58E-72

Ret 1442.708216 2379.952114 505.464318 0.212384239 -2.235251389 3.41E-75 9.47E-72

Adh1 1902.190669 3255.188572 549.1927669 0.168713042 -2.567356591 3.75E-73 9.12E-70

Msln 252.1515499 494.2822165 10.02088322 0.020273607 -5.624253426 1.13E-71 2.44E-68

Vipr1 1786.456057 2910.39607 662.5160444 0.227637761 -2.135188202 1.32E-71 2.57E-68

Tmem206 1263.036611 2078.861085 447.2121363 0.215123627 -2.216762112 4.38E-71 7.73E-68

Ddc 2779.160894 4387.906838 1170.414951 0.266736509 -1.906512791 7.7E-65 1.25E-61 Dapl1 967.3146553 101.5833857 1833.045925 18.04474139 4.173506562 6.29E-64 9.41E-61

Mlph 200.4059493 375.0934321 25.71846645 0.068565494 -3.866373477 7.02E-60 9.74E-57

Mlxipl 5125.357728 7876.089675 2374.625781 0.301498063 -1.729779361 1.85E-59 2.4E-56

Olfm4 213.2395034 390.4079846 36.07102216 0.092393147 -3.436070348 1.79E-54 2.17E-51

Cpne4 362.8613588 48.47323269 677.249485 13.97161789 3.804427187 1.58E-53 1.81E-50

Gipr 1759.006607 2728.607088 789.406127 0.289307365 -1.789325043 9.81E-53 1.06E-49 Galr1 292.41754 515.3555647 69.47951538 0.134818599 -2.890908553 1.38E-52 1.41E-49

Slc35f1 580.4125962 208.063014 952.7621784 4.57920012 2.195095615 8.79E-51 8.55E-48

Shc2 533.9384958 872.4881594 195.3888322 0.223944394 -2.158787543 5.74E-47 5.31E-44

Hist1h1d 278.9002494 77.06859917 480.7318997 6.237714255 2.641017465 1.49E-46 1.31E-43

Nell1 7196.431606 3819.941012 10572.9222 2.767823421 1.468751906 2.59E-45 2.19E-42

Baiap3 3879.681166 5737.715208 2021.647123 0.352343581 -1.504945164 3.14E-44 2.54E-41

Lipc 77.69045752 2.482891985 152.8980231 61.58061807 5.944404442 3.61E-44 2.81E-41 Pcsk6 402.7669877 666.1839459 139.3500295 0.209176505 -2.257207279 1.42E-43 1.06E-40

Kcnf1 262.9989507 504.8983894 21.09951198 0.04178962 -4.580711539 2.89E-43 2.08E-40

Opn3 173.4638888 38.20937786 308.7183998 8.079649997 3.014292798 2.55E-40 1.77E-37

Gucy2c 645.2084046 259.0534063 1031.363403 3.981277133 1.9932313 3.47E-39 2.33E-36

Stxbp5l 1485.791159 763.7823167 2207.800001 2.890614188 1.531376064 6.25E-38 4.05E-35

Gpsm1 1094.917898 1849.11105 340.7247461 0.18426408 -2.440153233 1.52E-37 9.51E-35

Vwa5b2 3790.997827 5436.630466 2145.365188 0.394613024 -1.341489523 6.14E-36 3.73E-33 Car15 3331.941249 520.4666425 6143.415856 11.80366877 3.561163437 1.26E-35 7.43E-33

Gpr137b-ps 2972.519354 1667.625141 4277.413566 2.564973064 1.358943675 4.08E-35 2.3E-32

Slc6a15 261.3937147 89.98333418 432.8040952 4.809825055 2.265984421 4.14E-35 2.3E-32

Tnfrsf11b 577.3342866 138.6533762 1016.015197 7.327734996 2.87336733 3.37E-34 1.82E-31

Ndrg1 2191.568721 3148.976318 1234.161124 0.391924549 -1.351352152 3.47E-34 1.82E-31

Mapk10 1518.431419 826.5968686 2210.26597 2.673934603 1.418964182 3.69E-34 1.89E-31

Myo3a 609.2523474 96.71938048 1121.785314 11.59835091 3.535847788 5.04E-34 2.51E-31 Adcy1 631.8242237 145.2239972 1118.42445 7.701374922 2.945116032 6.23E-34 3.03E-31

Cmtm8 243.5899951 81.70211443 405.4778759 4.962881055 2.311177878 1.14E-33 5.41E-31

Phyhip 185.9256046 319.3133921 52.53781718 0.16453371 -2.603544895 4.56E-33 2.11E-30

P2ry6 379.3015186 689.2945783 69.30845898 0.100549839 -3.314017321 1.95E-32 8.82E-30 Creg2 300.3303558 113.4864385 487.1742732 4.292797269 2.101918042 3.25E-32 1.44E-29

Hist1h1e 342.3854639 123.851476 560.9194519 4.52896865 2.179182553 1.22E-31 5.27E-29

Kcnk9 432.5624636 20.5155604 844.6093669 41.16920768 5.363493779 1.53E-31 6.48E-29

Whrn 508.7613793 780.1976121 237.3251465 0.304185943 -1.716974609 1.75E-31 7.25E-29

Fras1 300.9847094 483.0220403 118.9473785 0.246256627 -2.021765544 3.48E-31 1.41E-28

Akr1c13 1124.117051 617.5697322 1630.66437 2.640453838 1.40078592 5.84E-31 2.32E-28

Tspan2 595.1377878 902.3286659 287.9469097 0.31911533 -1.64785018 1.36E-30 5.3E-28 Insrr 7786.143225 12113.45809 3458.828364 0.285536 -1.808255447 2.26E-30 8.6E-28

Cd63 1081.670245 1571.059599 592.2808912 0.37699454 -1.407384464 6.15E-30 2.3E-27

Serpina7 1503.020345 284.2221742 2721.818515 9.576376379 3.259479855 1.22E-29 4.46E-27

Tnfaip8 336.2898218 142.908636 529.6710075 3.706361088 1.890003441 7.79E-29 2.8E-26

Stxbp1 3163.94948 4410.013834 1917.885127 0.434893222 -1.20126687 9.71E-29 3.43E-26

Fxyd6 904.8483392 1318.783063 490.9136151 0.372247437 -1.42566618 2.54E-28 8.82E-26

Ntm 118.5600679 28.28793589 208.8321999 7.38237674 2.884085363 3.22E-28 1.1E-25 Fez1 234.9306396 89.45251727 380.408762 4.252633392 2.08835649 3.6E-28 1.21E-25

Cabp7 316.6337962 497.2818256 135.9857669 0.273458148 -1.870608047 8.39E-28 2.76E-25

Rasd1 258.41042 439.4615355 77.35930454 0.176032026 -2.506090167 2.41E-27 7.81E-25

Lifr 1509.173336 2384.452785 633.8938872 0.265844596 -1.911344955 2.88E-27 9.17E-25

Cntfr 727.8069669 1062.275684 393.3382501 0.37027888 -1.433315832 3.55E-27 1.11E-24

Matn2 9281.397908 1077.291869 17485.50395 16.23098109 4.020678301 4.58E-27 1.41E-24

Gm4791 76.26912643 141.7108736 10.82737929 0.076404718 -3.710194467 2.87E-26 8.73E-24 Lrrc10b 545.8430087 810.1906251 281.4953922 0.347443408 -1.525150084 5.85E-26 1.75E-23

Spock2 19299.45974 9954.355616 28644.56386 2.877590973 1.524861539 1.01E-25 2.97E-23

Fam134b 1010.238586 577.8104034 1442.666768 2.496782266 1.320070015 1.02E-25 2.97E-23

Fam163a 295.9024978 133.5083242 458.2966714 3.432719826 1.779352111 1.19E-25 3.39E-23

Snph 762.1128337 1099.424773 424.8008947 0.386384685 -1.371890182 2.11E-25 5.86E-23

Ush2a 257.6994544 440.8009753 74.59793348 0.169232687 -2.562919846 2.63E-25 7.1E-23 Itga4 2029.649638 1239.057487 2820.24179 2.276118598 1.186575732 2.74E-25 7.29E-23

Secisbp2l 1754.461138 1063.811134 2445.111141 2.298444774 1.200658002 3.39E-25 8.9E-23

Lrrn1 2064.938795 2944.03899 1185.838601 0.402793103 -1.311889113 5.41E-25 1.4E-22

Gad2 160.4728818 11.49473105 309.4510326 26.92111988 4.75066652 5.85E-25 1.5E-22

Snap25 4612.145882 2975.947836 6248.343929 2.099614736 1.070124628 8.39E-25 2.12E-22

F13a1 374.0780481 63.92921456 684.2268817 10.70288266 3.419927511 9.28E-25 2.31E-22

Kcnh5 104.7383434 25.70227722 183.7744096 7.150121681 2.837967794 9.91E-25 2.42E-22 Agt 432.4513677 646.2863874 218.6163479 0.338265438 -1.563772316 9.94E-25 2.42E-22

G6pc2 57264.95876 76709.81673 37820.10079 0.493028173 -1.020258006 1.9E-24 4.55E-22

Chml 567.9568326 276.4997412 859.4139239 3.1081907 1.636075021 3.41E-24 8.08E-22

Glb1l2 1357.40932 1881.268962 833.5496791 0.44307842 -1.174366032 9.06E-24 2.12E-21

Hist1h2bc 949.9971315 564.6655154 1335.328748 2.364813702 1.241726534 1.2E-23 2.77E-21

Pkdcc 1569.667438 2165.039692 974.2951834 0.45001262 -1.151962636 3.64E-23 8.33E-21

Mcfd2 2846.732844 1661.22041 4032.245278 2.427278917 1.279339897 6.42E-23 1.45E-20 Kif19a 340.5503309 512.4744952 168.6261666 0.329043041 -1.603651782 1.13E-22 2.5E-20

Spock1 676.3573204 1077.026699 275.6879415 0.255971316 -1.965945943 1.3E-22 2.83E-20 Cyb5r3 3298.375738 4455.398425 2141.353052 0.480619879 -1.057031773 1.42E-22 3.06E-20

Folr1 1378.051363 681.168426 2074.9343 3.04613987 1.606982188 1.45E-22 3.1E-20

Nt5dc2 360.5055163 541.8681559 179.1428767 0.330602333 -1.596831188 1.67E-22 3.53E-20

Pnmal1 509.7748984 743.0033307 276.5464661 0.372200843 -1.425846771 1.86E-22 3.88E-20

Hist1h1c 1792.179797 1002.037529 2582.322064 2.577071205 1.3657324 2.36E-22 4.89E-20

1810008I18Rik 155.2878927 254.0860474 56.48973798 0.222325226 -2.169256441 2.95E-22 6.04E-20

Hes3 28.74832644 0 57.49665288 Inf Inf 5.33E-22 1.08E-19 Neurod1 1614.5089 2747.680706 481.3370936 0.175179413 -2.513094853 7.32E-22 1.47E-19

Tle4 440.2093881 234.3031205 646.1156557 2.757605849 1.463416264 8.15E-22 1.62E-19

Pxk 1874.726898 1198.709193 2550.744603 2.127909436 1.089436751 2.29E-21 4.44E-19

Tnfrsf23 601.9239577 257.2932972 946.5546181 3.67889342 1.879271881 2.95E-21 5.69E-19

Atp4a 54.08373436 101.3019199 6.865548853 0.067773137 -3.883142647 4.71E-21 8.97E-19

Fgd6 735.2621526 1029.11315 441.4111553 0.428923832 -1.221206619 5.41E-21 1.02E-18

Scel 242.7511985 112.2313001 373.2710968 3.325909052 1.733748718 7.38E-21 1.38E-18 Zfp462 1189.827812 749.8952451 1629.76038 2.173317394 1.119898883 8.44E-21 1.56E-18

Rap1gap2 7376.691374 9750.177169 5003.20558 0.513139966 -0.962575701 9.81E-21 1.8E-18

Paxip1 1681.706478 2278.369822 1085.043134 0.476236616 -1.070249546 1.52E-20 2.75E-18

Mapt 1164.982828 657.2469968 1672.718659 2.545038117 1.347687264 1.53E-20 2.76E-18

Ank2 863.961481 1196.184245 531.7387171 0.444529109 -1.1696502 1.73E-20 3.09E-18

Tmem218 677.499882 405.5985033 949.4012606 2.340741529 1.226965637 3.33E-20 5.88E-18

Clstn2 134.6428085 48.18290414 221.1027128 4.588820802 2.198123469 4.46E-20 7.81E-18 Slc39a11 571.5930088 330.1980689 812.9879487 2.462122057 1.299902284 5.48E-20 9.51E-18

Cerkl 753.0181864 457.1427391 1048.893634 2.294455416 1.198151774 2.47E-19 4.14E-17

Cntnap2 756.9662109 366.8518286 1147.080593 3.126822613 1.644697376 2.66E-19 4.42E-17

Myo1b 1639.96876 1080.718586 2199.218935 2.034959854 1.025000333 2.98E-19 4.87E-17

Rph3al 628.5211944 974.7304405 282.3119483 0.289630791 -1.787713111 3E-19 4.87E-17

Nr1i2 93.32878236 27.58100994 159.0765548 5.76761167 2.527974032 3.62E-19 5.82E-17 Cyb5b 7433.879233 4337.636648 10530.12182 2.427617311 1.279541014 9.98E-19 1.59E-16

Uap1l1 383.3542008 555.5049411 211.2034605 0.380200868 -1.395166271 1.13E-18 1.79E-16

Pappa 232.4510038 27.00696232 437.8950453 16.21415397 4.019181843 1.52E-18 2.35E-16

Adam10 2133.62934 1433.720706 2833.537975 1.97635283 0.982840529 1.53E-18 2.35E-16

Hist3h2a 585.8446345 338.3191369 833.370132 2.46326631 1.30057261 1.74E-18 2.66E-16

Gpr142 150.6578587 239.5910381 61.72467933 0.257625159 -1.956654604 4.2E-18 6.38E-16

Hist2h3c2 187.3416581 85.78726237 288.8960538 3.367586817 1.751715139 5.03E-18 7.59E-16 4930550C14Rik120.6478157 44.71262646 196.5830048 4.396588177 2.136384403 5.99E-18 8.96E-16

1-Mar 208.6242957 74.32506011 342.9235314 4.613834565 2.205966275 8.16E-18 1.21E-15

Mob3b 224.9502677 75.77248327 374.1280521 4.937518687 2.303786208 1.46E-17 2.15E-15

Tox3 1065.646 1436.498062 694.7939382 0.483672033 -1.047898974 1.5E-17 2.17E-15

Lgr4 902.2737316 584.1022033 1220.44526 2.089437864 1.063114856 1.61E-17 2.31E-15

Ppp4r1l-ps 1459.407435 770.7444489 2148.070421 2.787007321 1.478716792 1.75E-17 2.5E-15

Scn1b 182.9333893 283.5612168 82.30556179 0.290256766 -1.784598397 2.29E-17 3.25E-15 Dlgap3 565.5893085 319.6694837 811.5091333 2.538588056 1.344026304 3.34E-17 4.67E-15

Trpm3 930.0717565 241.0999388 1619.043574 6.715238428 2.747438624 3.76E-17 5.22E-15 Celf2 1228.205872 761.304605 1695.107139 2.226582012 1.154830752 4.71E-17 6.45E-15

Adamts16 300.5318757 9.463994672 591.5997567 62.51057585 5.966028388 6.85E-17 9.31E-15

Rab6a 5558.477228 3325.313636 7791.64082 2.343129603 1.228436755 7.11E-17 9.6E-15

Btbd17 148.0516232 234.215066 61.88818037 0.264236547 -1.920098071 8.01E-17 1.07E-14

Igsf1 851.8889009 549.9477799 1153.830022 2.09807197 1.069064167 1.52E-16 2.03E-14

Vldlr 836.3065358 1250.670468 421.9426035 0.337373124 -1.567583043 2.09E-16 2.75E-14

Cldn4 337.1505205 484.1628296 190.1382113 0.392715425 -1.34844383 2.39E-16 3.1E-14 Pam 14461.46934 10455.21132 18467.72735 1.766365765 0.820784116 2.39E-16 3.1E-14

Nrcam 760.0661757 328.4667537 1191.665598 3.627964122 1.859160189 3.6E-16 4.63E-14

Cnnm1 477.4286449 288.0185685 666.8387213 2.315262953 1.211176055 3.73E-16 4.77E-14

Gm2115 220.8071602 38.60815863 403.0061618 10.43836785 3.383824244 3.97E-16 5.05E-14

Vrk1 554.3190177 345.7636932 762.8743421 2.206346002 1.141659054 4.08E-16 5.15E-14

Adam9 1832.281913 1118.665887 2545.897939 2.27583407 1.186395375 4.41E-16 5.54E-14

Cyp4f39 75.30826969 139.6748546 10.94168481 0.078336826 -3.674165511 4.72E-16 5.88E-14 Mapk15 654.1421247 888.3878735 419.896376 0.472649828 -1.081156363 5.14E-16 6.36E-14

Nbl1 1887.765053 866.7439258 2908.78618 3.355992576 1.746739524 5.69E-16 7E-14

Abcb4 377.7094204 219.7568601 535.6619808 2.437521089 1.285414701 6.12E-16 7.48E-14

Mcoln3 37.10444534 69.94276239 4.266128292 0.060994564 -4.03517552 6.67E-16 8.1E-14

Me1 520.5544458 321.1792447 719.9296469 2.241519833 1.164477264 7.75E-16 9.36E-14

Chst11 2760.517759 1959.59612 3561.439398 1.81743542 0.861904101 9.47E-16 1.13E-13

Clip4 185.9874798 281.454384 90.52057558 0.321617217 -1.636583457 1.22E-15 1.44E-13 Lrp5 576.9369013 790.8814967 362.9923059 0.458971802 -1.123522573 1.31E-15 1.54E-13

2410021H03Rik128.1223198 201.1642893 55.08035032 0.273807794 -1.86876458 1.64E-15 1.91E-13

Aatk 826.1038992 1107.205965 545.0018329 0.492231662 -1.022590634 1.72E-15 1.99E-13

Pde7b 314.8187197 178.7631659 450.8742735 2.522187785 1.334675693 1.87E-15 2.15E-13

Fam20a 502.978439 696.3005262 309.6563518 0.444716527 -1.169042074 2.27E-15 2.6E-13

Glul 4065.200206 6327.273547 1803.126864 0.28497691 -1.811083064 3.91E-15 4.4E-13 Ftl1 4373.374953 5601.555468 3145.194438 0.561485904 -0.832678289 4.04E-15 4.51E-13

Tns3 4200.155908 3021.180892 5379.130924 1.780472973 0.832260536 4.45E-15 4.94E-13

C2cd4c 212.3229353 354.1490796 70.49679098 0.199059648 -2.3287273 4.58E-15 5.06E-13

Scg3 38324.42182 28243.98494 48404.8587 1.713811234 0.777208214 5.59E-15 6.14E-13

Cdh8 679.0412894 923.500891 434.5816879 0.470580692 -1.087485969 8.01E-15 8.75E-13

Reep6 1107.026532 1454.948043 759.1050224 0.521740296 -0.938596232 1.01E-14 1.09E-12

Lrp8 2987.280923 1145.957549 4828.604297 4.213597878 2.075052638 1.02E-14 1.1E-12 Rnf157 272.2817112 390.8211678 153.7422545 0.393382619 -1.34599488 1.06E-14 1.13E-12

Dcx 694.6098203 448.539661 940.6799796 2.097205802 1.068468442 1.21E-14 1.28E-12

Gadd45g 596.772981 808.9404668 384.6054951 0.47544351 -1.072654157 1.36E-14 1.43E-12

Jph3 432.9624397 600.6146367 265.3102428 0.441731231 -1.178759259 1.56E-14 1.63E-12

Slc29a4 464.3431786 636.4418569 292.2445004 0.459184916 -1.122852845 1.58E-14 1.64E-12

Tnfrsf22 276.0840932 157.8382686 394.3299178 2.498316291 1.320956136 1.61E-14 1.66E-12

Mtss1l 1010.550126 1482.047316 539.0529371 0.363721813 -1.459092645 1.74E-14 1.79E-12 T2 177.5640434 314.4863379 40.64174902 0.129232161 -2.951962949 1.81E-14 1.85E-12

Gjb4 58.29962321 4.107990035 112.4912564 27.38352708 4.775236377 1.9E-14 1.94E-12 Cyp4v3 569.7293734 769.7627578 369.6959889 0.480272636 -1.058074483 2.11E-14 2.13E-12

Clmn 586.797151 316.3601909 857.2341111 2.709677563 1.438121189 2.18E-14 2.19E-12

Rnf130 2151.050259 2771.488748 1530.61177 0.552270606 -0.856552751 2.9E-14 2.89E-12

Akr1c12 1222.781673 828.0816639 1617.481682 1.953287644 0.965904418 3.08E-14 3.06E-12

Enho 1263.591092 1796.596435 730.5857487 0.406649893 -1.29814086 4.2E-14 4.15E-12

Cyp26a1 26.88536274 2.062559665 51.70816582 25.06990062 4.647884372 4.39E-14 4.31E-12

Hadh 16236.93473 12111.45596 20362.4135 1.681252325 0.749536263 4.84E-14 4.73E-12 Edem1 2962.82582 2166.248399 3759.403242 1.73544421 0.795304987 5.01E-14 4.87E-12

Aqp11 167.8469083 252.4392611 83.25455557 0.329800346 -1.600335184 5.27E-14 5.08E-12

Acss2 896.1876146 614.3340823 1178.041147 1.917590413 0.939294602 5.61E-14 5.38E-12

Vwa5b1 144.8667917 220.5080521 69.22553133 0.313936524 -1.671455211 7.36E-14 7.01E-12

Sema3c 1178.649745 208.6790562 2148.620434 10.29629169 3.364052926 7.6E-14 7.17E-12

Akr1d1 131.3670375 18.29071625 244.4433588 13.36434044 3.740316734 9.29E-14 8.72E-12

Vapb 4762.961155 3279.902951 6246.01936 1.904330541 0.929283913 1.06E-13 9.89E-12 Magi1 807.0208913 540.7866751 1073.255108 1.984618255 0.988861529 1.13E-13 1.05E-11

Zc3h10 432.0823548 590.811379 273.3533307 0.462674451 -1.111930659 1.5E-13 1.39E-11

Sh3kbp1 719.8935605 483.6437317 956.1433893 1.976958092 0.983282289 1.54E-13 1.42E-11

Cftr 483.2615782 24.25659295 942.2665634 38.84579196 5.279686419 2.02E-13 1.85E-11

Aplnr 1237.837291 105.4401855 2370.234397 22.47942173 4.490533018 2.16E-13 1.97E-11

Acvr1c 786.3417054 229.0621594 1343.621251 5.865749519 2.552315466 3.23E-13 2.92E-11

Galnt4 1072.409886 753.3914674 1391.428304 1.8468862 0.885094974 3.95E-13 3.51E-11 H2-Q2 337.0427874 492.4272388 181.6583359 0.368903914 -1.438682998 3.96E-13 3.51E-11

Sdc4 902.3844345 590.5855665 1214.183303 2.055897352 1.039768235 4.63E-13 4.09E-11

Scd2 9418.408898 5564.205653 13272.61214 2.385356144 1.254204683 4.86E-13 4.27E-11

Dpys 29.84444221 2.542839972 57.14604445 22.4733153 4.490141064 5.03E-13 4.4E-11

Clic4 1569.779549 2011.382977 1128.176121 0.560895729 -0.834195498 5.36E-13 4.67E-11

Laptm4b 1691.594916 1078.314865 2304.874968 2.137478618 1.095909989 5.85E-13 5.07E-11 Cln6 1283.541593 1648.816868 918.266318 0.556924384 -0.844446636 6.17E-13 5.33E-11

Grin2c 75.68668657 127.3177616 24.05561158 0.188941521 -2.403988314 6.27E-13 5.39E-11

Ralgps2 652.544871 439.0273079 866.0624342 1.972684657 0.980160353 6.96E-13 5.95E-11

Minpp1 544.3409581 363.5090534 725.1728628 1.994923802 0.996333642 8.59E-13 7.29E-11

Trnp1 159.9445791 238.8453128 81.04384528 0.339315201 -1.559302033 9.97E-13 8.43E-11

Ghitm 3635.073122 2706.114345 4564.031898 1.686562841 0.754086074 1.04E-12 8.73E-11

Slc14a2 198.6107486 112.5293466 284.6921506 2.529936939 1.339101425 1.04E-12 8.74E-11 Ugt2b34 2295.116905 1170.74837 3419.48544 2.920768911 1.546348218 1.25E-12 1.04E-10

Slc2a5 3612.009441 4621.492737 2602.526144 0.563135396 -0.82844626 1.33E-12 1.1E-10

Tubb3 401.9982197 606.2182989 197.7781404 0.326249044 -1.615954421 1.36E-12 1.12E-10

Klhl29 100.894812 40.29676657 161.4928574 4.007588477 2.002734372 1.8E-12 1.46E-10

Ero1lb 71510.55061 36081.2533 106939.8479 2.963861788 1.567478173 1.87E-12 1.51E-10

Npepl1 2659.84573 1823.799178 3495.892283 1.916818653 0.938713853 2.11E-12 1.7E-10

Mdh1 4611.550603 3489.409913 5733.691293 1.643169314 0.716481145 2.36E-12 1.89E-10 Cbfa2t3 794.3409752 1128.679201 460.0027496 0.407558454 -1.294921104 2.54E-12 2.02E-10

Foxred2 258.7749852 380.0391759 137.5107945 0.361833209 -1.466603271 2.6E-12 2.06E-10 Hist1h3d 60.07158593 19.47549629 100.6676756 5.168940193 2.36986851 2.7E-12 2.14E-10

Trio 1440.683456 1833.995717 1047.371195 0.571087045 -0.808217436 2.71E-12 2.14E-10

Trpc4 110.9012541 202.3042274 19.49828073 0.096380985 -3.375107643 3.2E-12 2.5E-10

Akap13 4747.506017 3358.149561 6136.862473 1.827453591 0.869834768 3.47E-12 2.68E-10

Prkar2a 1108.071944 756.3806498 1459.763238 1.929932024 0.948550034 3.95E-12 3.05E-10

Fhod3 510.0741769 676.9167376 343.2316163 0.507051454 -0.979795939 4.02E-12 3.08E-10

Camk1d 641.962342 303.7211908 980.2034932 3.22731348 1.690333719 4.1E-12 3.12E-10 Gcnt1 467.6272542 160.3859337 774.8685747 4.831275141 2.272404017 4.52E-12 3.42E-10

Igsf5 254.2646232 151.5295489 356.9996976 2.355974133 1.2363237 4.59E-12 3.46E-10

Pbx3 831.9572594 581.894855 1082.019664 1.859476252 0.894896323 4.75E-12 3.56E-10

Spc25 1544.830123 2238.326414 851.333832 0.380343915 -1.39462357 5.05E-12 3.78E-10

Gprc5c 383.2081131 518.128758 248.2874682 0.479200323 -1.061299214 5.27E-12 3.93E-10

Xiap 1925.507215 1418.444522 2432.569907 1.714955974 0.77817154 5.55E-12 4.12E-10

Scnn1b 4109.882724 2489.609403 5730.156046 2.301628536 1.202655013 5.71E-12 4.22E-10 Pitpnm2 1864.466367 2345.314499 1383.618235 0.589949977 -0.761335464 5.86E-12 4.32E-10

Stk32b 226.061881 53.45258406 398.6711779 7.45840795 2.89886771 6.05E-12 4.44E-10

Plch1 270.1407067 376.0635064 164.2179071 0.436675998 -1.195364859 7.34E-12 5.32E-10

Kcnj13 83.29181701 7.480508326 159.1031257 21.26902595 4.410682059 7.43E-12 5.37E-10

Ppp1r1a 6164.601943 4694.328482 7634.875404 1.626404167 0.701685816 7.57E-12 5.45E-10

Uxs1 256.7997098 154.5612383 359.0381812 2.322950988 1.215958715 8.07E-12 5.78E-10

Cpe 39634.68575 48835.31692 30434.05459 0.623197647 -0.682238309 8.08E-12 5.78E-10 Snap91 849.4125416 522.0414042 1176.783679 2.254196064 1.172613003 1.08E-11 7.7E-10

Gcgr 940.060313 672.8420454 1207.278581 1.794297174 0.843418851 1.15E-11 8.11E-10

Fmnl2 1308.900414 1658.446895 959.3539328 0.578465271 -0.789697747 1.29E-11 9.09E-10

Chd5 949.8407147 1223.868871 675.8125585 0.552193601 -0.856753926 1.33E-11 9.32E-10

Lrrn2 541.4724788 257.8804639 825.0644937 3.199406738 1.677804413 1.33E-11 9.32E-10

Abcc4 581.7604769 763.641436 399.8795177 0.523648271 -0.933330001 1.41E-11 9.8E-10 Tmod2 4104.672462 5091.646142 3117.698782 0.612316468 -0.70765061 1.6E-11 1.11E-09

Pcsk1n 8227.665348 11431.87498 5023.455714 0.439425354 -1.186309981 1.66E-11 1.15E-09

A530058N18Rik985.0946404 711.8158801 1258.373401 1.767835526 0.821984057 1.73E-11 1.19E-09

Calr 20740.96601 16080.51645 25401.41557 1.579639289 0.659595157 1.75E-11 1.2E-09

Kifc3 1097.532505 1402.39273 792.6722805 0.565228458 -0.82309399 2.02E-11 1.38E-09

Arap2 263.7253854 159.4730533 367.9777175 2.307460162 1.20630574 2.23E-11 1.51E-09

Enpep 2641.279799 968.4319036 4314.127694 4.454755856 2.155346367 2.26E-11 1.52E-09 Rapgef5 285.5123402 178.6515547 392.3731258 2.196304008 1.135077763 2.29E-11 1.54E-09

Fh1 1842.33889 975.6053112 2709.07247 2.776811933 1.47342947 2.33E-11 1.56E-09

Cd99l2 1090.096406 793.0912257 1387.101586 1.748981128 0.806514722 2.43E-11 1.63E-09

Stox1 155.1831692 226.1866115 84.17972686 0.372169362 -1.425968802 2.67E-11 1.77E-09

3-Sep 213.6787042 301.5961293 125.7612792 0.41698572 -1.261930116 2.75E-11 1.82E-09

2700081O15Rik582.0779814 762.3061068 401.8498561 0.527150252 -0.923713868 3E-11 1.97E-09

Acyp2 147.6748221 78.48131539 216.8683289 2.763311596 1.466398252 3.03E-11 1.99E-09 Prkag2 660.3790668 856.9887193 463.7694143 0.541161632 -0.885868537 3.11E-11 2.04E-09

C2cd4b 296.691389 428.720523 164.6622549 0.384078312 -1.380527593 3.16E-11 2.06E-09 Slc6a6 6472.397243 4988.815972 7955.978514 1.594762877 0.673341928 3.48E-11 2.26E-09

Celf3 4236.131967 5244.935509 3227.328426 0.615322804 -0.700584634 3.93E-11 2.55E-09

Meg3 18548.71911 22622.5809 14474.85731 0.639841112 -0.644214402 4.17E-11 2.69E-09

Cyp51 1398.855334 900.9808959 1896.729771 2.105183118 1.07394573 4.59E-11 2.94E-09

Plagl1 179.9003829 265.7069197 94.09384611 0.354126442 -1.497663523 4.96E-11 3.17E-09

Pdyn 2096.703758 196.5757346 3996.831781 20.33227443 4.345699703 5.16E-11 3.29E-09

Aldh1a3 3862.675415 53.17696767 7672.173863 144.2762572 7.172690092 5.2E-11 3.31E-09 Mast1 436.1287207 616.0280297 256.2294116 0.415937911 -1.265559909 5.24E-11 3.32E-09

Kiss1r 143.9451577 76.40933526 211.4809802 2.767737469 1.468707104 5.62E-11 3.55E-09

Grid1 60.20536489 12.04023287 108.3704969 9.000697748 3.170036846 6.07E-11 3.82E-09

Dach1 906.5330585 1191.666984 621.399133 0.521453679 -0.939388992 6.46E-11 4.03E-09

Th 359.0764843 591.4675519 126.6854168 0.214188279 -2.223048564 7.3E-11 4.53E-09

Prrt3 92.00889726 142.5466949 41.47109967 0.290929928 -1.781256381 7.69E-11 4.76E-09

Erp29 1739.315902 1288.69355 2189.938254 1.699347571 0.76498096 8.49E-11 5.24E-09 Lingo1 649.6350592 268.4651527 1030.804966 3.839622964 1.940964651 8.81E-11 5.42E-09

Clip3 899.5716308 1146.014254 653.1290072 0.569913511 -0.8111851 9.31E-11 5.71E-09

Commd7 948.5134562 694.2338287 1202.793084 1.732547499 0.792894905 9.5E-11 5.81E-09

Sh3d19 906.0338661 1149.025776 663.0419562 0.577047069 -0.793239092 1.25E-10 7.61E-09

Esyt1 2546.953383 3412.306787 1681.599979 0.492804453 -1.020912803 1.44E-10 8.69E-09

Osbpl10 355.503867 203.8013359 507.206398 2.488729506 1.315409436 1.79E-10 1.08E-08

Stxbp6 828.1527669 599.1252734 1057.18026 1.764539584 0.819291794 1.87E-10 1.12E-08 Sntg1 439.0287262 298.9660952 579.0913572 1.936980034 0.953809083 1.93E-10 1.15E-08

Fam171b 294.976577 442.2240928 147.7290612 0.334059278 -1.581823966 1.94E-10 1.15E-08

Mthfd2 821.964545 1204.669037 439.2600532 0.364631313 -1.455489634 2.02E-10 1.2E-08

B4galnt4 144.0200568 209.5421237 78.49798995 0.374616753 -1.416512677 2.06E-10 1.22E-08

Ogfrl1 401.4392621 263.2603187 539.6182055 2.049751395 1.035448943 2.14E-10 1.25E-08

Scgn 3922.542979 4834.131364 3010.954593 0.622853283 -0.683035726 2.14E-10 1.26E-08 Dab2ip 829.7885692 1057.012208 602.5649302 0.570064305 -0.810803425 2.45E-10 1.43E-08

Rtkn2 134.8727059 234.0302511 35.71516069 0.152609163 -2.712086509 2.53E-10 1.47E-08

Tmem9b 862.8209413 633.000309 1092.641574 1.726131185 0.787542113 2.86E-10 1.65E-08

Runx1t1 310.4014464 416.6458676 204.1570252 0.49000132 -1.029142458 3.1E-10 1.79E-08

Pag1 957.8548609 674.7927683 1240.916953 1.838960066 0.878890151 3.26E-10 1.88E-08

Gnas 33074.30736 26191.17243 39957.44229 1.525607241 0.609383596 4.13E-10 2.36E-08

Hist3h2ba 226.865915 126.1900913 327.5417388 2.595621696 1.37608013 4.2E-10 2.38E-08 Plxna4 405.9954971 142.5237161 669.4672781 4.697234232 2.231811537 4.39E-10 2.48E-08

Gramd1a 1901.669749 2359.116733 1444.222766 0.61218792 -0.707953518 5.05E-10 2.84E-08

Ctnnal1 1696.872641 765.0282239 2628.717057 3.436104676 1.780773987 5.24E-10 2.94E-08

Samd9l 1166.005538 864.5095838 1467.501492 1.697495921 0.763408108 5.66E-10 3.16E-08

Psd 887.4893838 1122.547571 652.4311971 0.581205834 -0.78287891 5.73E-10 3.19E-08

Elavl4 1137.526311 814.6644006 1460.388222 1.792625553 0.842074167 5.76E-10 3.2E-08

Axin2 146.2518896 210.1324403 82.37133898 0.391997251 -1.351084557 6.23E-10 3.44E-08 Mc5r 25.93773112 4.29596392 47.57949833 11.07539524 3.469286278 6.52E-10 3.59E-08

Kremen1 529.8871802 687.141372 372.6329884 0.542294502 -0.88285155 6.9E-10 3.79E-08 Arhgap6 586.0956641 415.6507912 756.5405369 1.820134961 0.864045429 6.94E-10 3.8E-08

Upp2 45.65126742 77.29481464 14.0077202 0.181224579 -2.464149461 7.76E-10 4.24E-08

Atp1b2 749.0623566 954.9397068 543.1850063 0.568816023 -0.81396599 7.94E-10 4.32E-08

Fkbp2 1577.281688 1205.900334 1948.663043 1.615940379 0.69237397 8.24E-10 4.47E-08

Myo18a 1925.85116 2372.582327 1479.119993 0.623421989 -0.681719054 1.02E-09 5.49E-08

Sult4a1 219.8624539 304.538913 135.1859948 0.443903846 -1.171680886 1.06E-09 5.68E-08

Edem2 3254.402864 2112.418456 4396.387273 2.081210407 1.057422826 1.07E-09 5.73E-08 Smpd3 542.3614471 702.4095711 382.3133231 0.544288317 -0.877557026 1.1E-09 5.89E-08

Hist1h4i 288.7575766 189.3074623 388.2076908 2.050672943 1.036097418 1.1E-09 5.89E-08

Pitpnc1 973.7795132 725.3434803 1222.215546 1.685016243 0.752762499 1.11E-09 5.91E-08

Tmem98 143.4452993 206.1312181 80.75938052 0.391786267 -1.351861265 1.15E-09 6.08E-08

Hist1h2ad 41.88743206 13.27925719 70.49560694 5.308701076 2.408358908 1.17E-09 6.17E-08

Arhgef25 297.7846615 399.8295817 195.7397413 0.489557927 -1.030448517 1.18E-09 6.22E-08

Nipal2 737.1208152 539.194709 935.0469214 1.734154482 0.794232423 1.21E-09 6.35E-08 Nudt7 479.741404 335.745334 623.737474 1.857769597 0.893571588 1.21E-09 6.35E-08

Hist1h2bg 123.4598639 66.89281703 180.0269109 2.691274173 1.428289373 1.24E-09 6.52E-08

Srrm4 693.0794951 898.8153234 487.3436668 0.542206674 -0.883085224 1.29E-09 6.74E-08

Megf9 1572.788283 1080.939701 2064.636865 1.910038889 0.933602012 1.33E-09 6.94E-08

Stk32a 2681.915338 1885.200774 3478.629902 1.845230465 0.883801017 1.35E-09 7E-08

Emid1 100.5401693 150.8384617 50.24187691 0.333083992 -1.586042077 1.37E-09 7.1E-08

Cd164l2 112.5006043 167.4184425 57.58276619 0.343945179 -1.539749461 1.42E-09 7.32E-08 Rnf150 1164.284585 707.8404496 1620.72872 2.289680846 1.195146518 1.43E-09 7.35E-08

Sdc3 1370.474837 1704.074139 1036.875536 0.608468559 -0.716745378 1.61E-09 8.21E-08

Gpc4 1531.631067 1891.614602 1171.647532 0.619390192 -0.691079557 1.61E-09 8.21E-08

Cdh4 398.7554913 180.748373 616.7626096 3.412271986 1.770732646 1.72E-09 8.74E-08

Galns 414.6184063 540.1195909 289.1172217 0.535283716 -0.90162433 1.74E-09 8.83E-08

Flcn 1592.360154 1969.830348 1214.889961 0.616748525 -0.697245735 1.86E-09 9.38E-08 Col20a1 345.1716596 457.2077308 233.1355884 0.509911738 -0.971680548 1.96E-09 9.86E-08

Pla2g12a 376.5888495 497.6799281 255.497771 0.513377688 -0.961907498 2.16E-09 1.09E-07

Wars 2367.925653 1793.808761 2942.042545 1.640109363 0.713792017 2.25E-09 1.13E-07

Cntnap1 227.9188404 146.0345411 309.8031396 2.121437417 1.085042119 2.44E-09 1.21E-07

Steap2 1010.05362 1284.329157 735.778082 0.572889028 -0.803672388 2.44E-09 1.21E-07

Glce 1187.572481 736.6478752 1638.497086 2.224260927 1.15332604 2.49E-09 1.23E-07

Gatsl2 3002.309155 3664.55406 2340.064249 0.638567261 -0.647089506 2.49E-09 1.23E-07 Cacna1c 599.2130519 788.9904527 409.4356511 0.518936129 -0.946371114 2.81E-09 1.38E-07

Grb10 1275.909657 1579.638517 972.1807968 0.615445107 -0.700297909 2.99E-09 1.46E-07

Dock3 181.05634 108.9185931 253.1940869 2.324617677 1.21699346 2.99E-09 1.46E-07

Elovl4 56.68708588 91.50323025 21.87094152 0.239018245 -2.064807346 3.06E-09 1.49E-07

Atf5 2124.36234 2918.87967 1329.845011 0.455601176 -1.134156623 3.14E-09 1.52E-07

Itpr2 319.0287749 199.0499025 439.0076474 2.20551551 1.141115906 3.63E-09 1.76E-07

Fgl1 95.31808591 12.88418409 177.7519877 13.79613847 3.786192609 3.86E-09 1.86E-07 Foxo6 123.9745521 179.7118526 68.23725166 0.379703679 -1.397054116 3.93E-09 1.89E-07

Jph4 103.2484735 153.1652121 53.3317348 0.34819744 -1.522022498 4.42E-09 2.12E-07 Tmem132a 262.4918088 353.6568341 171.3267835 0.484443582 -1.045599435 4.47E-09 2.13E-07

Nr1d1 1943.082743 1219.184009 2666.981478 2.1875135 1.129291921 4.73E-09 2.24E-07

Nog 15.94773517 1.190492832 30.7049775 25.79182055 4.688841706 4.98E-09 2.35E-07

S100g 22.22723511 3.704787009 40.74968322 10.99919729 3.459326336 5.53E-09 2.6E-07

Hs1bp3 413.1878526 535.1951712 291.1805339 0.544064202 -0.878151188 5.53E-09 2.6E-07

Mdm1 3156.173435 4946.568976 1365.777895 0.276106105 -1.856705305 6.33E-09 2.96E-07

Amotl1 1186.219641 1469.344286 903.0949959 0.614624499 -0.702222821 6.64E-09 3.1E-07 Ctnnbip1 332.1395469 436.2773869 228.0017069 0.522607208 -0.936201073 6.79E-09 3.16E-07

Etl4 890.1421177 1136.876522 643.4077133 0.565943355 -0.821270433 6.81E-09 3.16E-07

Ptprm 1375.990296 1055.311032 1696.66956 1.607743602 0.685037349 6.93E-09 3.21E-07

Pdp1 457.9949691 326.4423242 589.547614 1.805977872 0.852780216 6.96E-09 3.22E-07

Atp1b1 5566.095285 4449.130709 6683.059861 1.502104635 0.586985313 7.22E-09 3.33E-07

Arl6ip1 2062.319132 1616.392553 2508.245711 1.5517553 0.633901074 7.29E-09 3.35E-07

Trpm5 1688.649455 2413.71153 963.5873803 0.399213977 -1.324765861 7.59E-09 3.48E-07 Zdhhc23 131.9580236 75.3787007 188.5373466 2.501201862 1.322621496 8.19E-09 3.75E-07

Brsk2 368.6570584 480.0487147 257.265402 0.535915198 -0.899923365 8.32E-09 3.8E-07

Lypd6 25.49366118 5.12521206 45.86211031 8.948334191 3.161619137 8.75E-09 3.96E-07

Gad1 1177.741379 1870.386061 485.0966971 0.259356454 -1.946991822 8.92E-09 4.02E-07

Zfp174 315.0951523 412.6907416 217.499563 0.527027968 -0.924048571 9.43E-09 4.24E-07

Slc7a8 6181.232844 3460.590319 8901.875369 2.572357473 1.363091144 9.95E-09 4.47E-07

Dhrs4 416.9607044 537.9258574 295.9955513 0.550253436 -0.861831846 1.08E-08 4.83E-07 Slc1a4 395.0641592 610.2728304 179.855488 0.294713248 -1.762616181 1.13E-08 5.04E-07

Pitrm1 800.9977059 999.7907786 602.2046332 0.602330654 -0.731372413 1.18E-08 5.27E-07

Cdh7 98.36872459 171.1158232 25.62162594 0.149732652 -2.739539237 1.19E-08 5.27E-07

B3galt5 1491.356569 729.4477444 2253.265394 3.089001797 1.62714071 1.27E-08 5.6E-07

Rcor2 77.25538521 116.3942399 38.11653052 0.327477808 -1.610530952 1.29E-08 5.7E-07

Rhbdl3 183.0013703 252.0670301 113.9357106 0.452005606 -1.145587431 1.31E-08 5.76E-07 Slc16a12 3638.021675 2400.846342 4875.197008 2.030616005 1.021917448 1.34E-08 5.89E-07

Eno2 979.2295406 1212.461243 745.9978385 0.615275616 -0.700695276 1.44E-08 6.33E-07

Sh3rf1 475.7825172 343.3876967 608.1773378 1.771109867 0.824653709 1.48E-08 6.49E-07

Tlr2 305.6451938 407.3584212 203.9319663 0.500620475 -0.998210797 1.5E-08 6.54E-07

Il20ra 30.79047491 7.971774955 53.60917486 6.724873088 2.749507041 1.51E-08 6.57E-07

Tcf20 1860.152387 1458.516209 2261.788565 1.550746266 0.632962651 1.6E-08 6.91E-07

Tmem27 15461.58475 11142.63102 19780.53849 1.775212555 0.827991776 1.61E-08 6.95E-07 Gstz1 1763.189496 2154.476926 1371.902066 0.636768048 -0.65116015 1.64E-08 7.06E-07

Nespas 44.62645496 15.62512391 73.62778601 4.712140936 2.23638269 1.66E-08 7.14E-07

Usp18 810.5153014 578.8833534 1042.147249 1.80027158 0.848214561 1.77E-08 7.61E-07

Rab39 149.2390513 87.9958285 210.482274 2.39195741 1.258191702 1.85E-08 7.93E-07

Synpr 741.847147 350.3929569 1133.301337 3.23437248 1.693485834 1.88E-08 8.05E-07

Map3k15 3690.548834 4827.67644 2553.421227 0.528913082 -0.918897435 1.93E-08 8.25E-07

Aplp1 10492.54902 12582.99445 8402.103586 0.667734824 -0.582652813 2.01E-08 8.52E-07 Mctp1 146.061323 30.77368427 261.3489618 8.492612049 3.086208348 2.15E-08 9.09E-07

Syvn1 2837.252945 2185.518956 3488.986935 1.596411198 0.674832304 2.3E-08 9.71E-07 Slc22a4 104.0267056 55.77189194 152.2815193 2.730434885 1.449130752 2.33E-08 9.8E-07

Cntn3 429.965816 187.9508497 671.9807822 3.575300581 1.838064537 2.39E-08 1E-06

5730559C18Rik34.97149903 59.41673096 10.5262671 0.177159984 -2.496875324 2.45E-08 1.03E-06

Hist1h2be 174.8936752 111.0806419 238.7067085 2.148949667 1.103631692 2.66E-08 1.11E-06

Sult1c2 63.15838198 98.30050599 28.01625797 0.285006244 -1.81093457 2.94E-08 1.22E-06

Nmral1 302.2957318 207.0699609 397.5215027 1.919744907 0.94091462 2.99E-08 1.24E-06

Capn9 49.6247717 82.81796528 16.43157813 0.198405963 -2.333472712 3.13E-08 1.3E-06 Inpp4a 1956.070564 2357.346723 1554.794405 0.659552704 -0.600440147 3.3E-08 1.36E-06

Tmem151b 79.92160777 123.0686084 36.77460712 0.29881387 -1.742680981 3.35E-08 1.38E-06

Rab3b 656.2784817 818.8901014 493.666862 0.602848735 -0.730132043 3.35E-08 1.38E-06

Pea15a 3651.729934 2746.151097 4557.30877 1.659525864 0.730771114 3.58E-08 1.47E-06

Pgf 238.9817831 320.0892563 157.8743099 0.493219647 -1.019697826 3.61E-08 1.48E-06

Lrrﬁp2 1886.364493 1492.909712 2279.819274 1.527097892 0.610792547 3.73E-08 1.52E-06

Sowaha 59.91203628 93.13160579 26.69246677 0.286610185 -1.802838216 3.96E-08 1.61E-06 Capn2 1081.337541 1327.052482 835.6226002 0.62968316 -0.66730201 4.02E-08 1.63E-06

Egf 689.4334892 308.9607409 1069.906237 3.462919704 1.791988936 4.11E-08 1.66E-06

Tmcc2 660.1520608 825.3793959 494.9247257 0.599633003 -0.737848306 4.35E-08 1.75E-06

Dpp7 795.8066015 986.733763 604.8794399 0.6130118 -0.706013251 4.66E-08 1.87E-06

Ak5 56.30443035 88.57959008 24.02927063 0.27127322 -1.882181462 4.69E-08 1.88E-06

Abca4 54.86031862 85.87817329 23.84246395 0.277631242 -1.848758168 5.02E-08 1.99E-06

Ric8b 1621.442117 1276.930886 1965.953348 1.539592603 0.622548645 5.37E-08 2.13E-06 Stim1 2392.738721 1905.003214 2880.474229 1.512057412 0.596512919 5.58E-08 2.21E-06

G6pdx 757.6926748 579.7319983 935.6533513 1.61394119 0.69058801 5.68E-08 2.24E-06

Ppm1h 880.690408 604.5344435 1156.846372 1.91361532 0.936300845 5.88E-08 2.31E-06

Eepd1 124.2895089 176.4311328 72.14788497 0.408929444 -1.290076152 5.88E-08 2.31E-06

Cldn8 378.0880428 45.98704505 710.1890406 15.44324146 3.948903694 6E-08 2.35E-06

Cdh22 172.9632483 237.1802343 108.7462622 0.45849631 -1.125017972 6.07E-08 2.37E-06 Dbp 507.930948 299.2086594 716.6532366 2.395162085 1.260123289 6.37E-08 2.48E-06

Atp1a1 15754.18224 12864.02885 18644.33564 1.449338761 0.535394843 6.42E-08 2.5E-06

Syne2 1495.980478 916.845916 2075.115039 2.263319281 1.178440116 7.09E-08 2.75E-06

Itpr3 1054.753855 1314.863789 794.6439202 0.604354555 -0.726532915 7.13E-08 2.76E-06

Vash1 378.6289463 550.393663 206.8642296 0.375847768 -1.41177966 7.64E-08 2.95E-06

Cgn 783.4557358 987.384549 579.5269226 0.586931326 -0.768736384 7.66E-08 2.95E-06

Plcb1 497.2063526 625.8047921 368.607913 0.589014206 -0.763625664 7.67E-08 2.95E-06 Asb11 47.09348769 75.52256536 18.66441002 0.247136865 -2.016617865 8.1E-08 3.11E-06

Nptx1 576.9678278 722.3615602 431.5740954 0.597448867 -0.743112851 8.15E-08 3.12E-06

Hdac6 2613.040247 3144.187864 2081.892629 0.662140024 -0.594791755 8.54E-08 3.24E-06

Tnfrsf21 702.0661035 373.9992877 1030.132919 2.754371341 1.461723075 8.55E-08 3.24E-06

Cox5a 678.4329196 515.9615083 840.9043308 1.629781132 0.704678233 8.58E-08 3.25E-06

Npy 3395.044874 1432.648061 5357.441687 3.739537875 1.902859995 9.06E-08 3.42E-06

Nlk 1326.225889 1041.280482 1611.171295 1.547298084 0.629751156 9.26E-08 3.49E-06 Kctd8 164.0102936 105.8991987 222.1213886 2.097479409 1.068656648 9.47E-08 3.56E-06

Sqle 2245.004609 1797.022851 2692.986368 1.49858215 0.583598172 9.58E-08 3.59E-06 Hist1h4h 104.5169936 49.69996198 159.3340252 3.205918453 1.680737729 9.74E-08 3.64E-06

Arhgef37 79.67647528 117.9317136 41.42123694 0.351230688 -1.509509191 9.83E-08 3.67E-06

Ntrk1 53.14736124 83.04745823 23.24726425 0.279927463 -1.836875064 1.01E-07 3.74E-06

Fam57b 329.617941 425.1266598 234.1092222 0.550681113 -0.860710966 1.01E-07 3.77E-06

Lrrc24 413.9040779 303.1124998 524.6956559 1.731026125 0.791627498 1.06E-07 3.92E-06

Tesk1 1169.033037 1445.329461 892.7366134 0.617669976 -0.69509189 1.07E-07 3.94E-06

Klhl33 58.80996207 89.97846358 27.64146056 0.307200851 -1.702745884 1.08E-07 3.99E-06 Gmcl1 522.6693923 390.4299482 654.9088364 1.677404204 0.746230377 1.09E-07 4.02E-06

Tgfa 658.0026701 476.6066913 839.3986488 1.761197784 0.816556935 1.12E-07 4.11E-06

Lgmn 766.2677078 587.8569126 944.6785029 1.606987147 0.68435839 1.23E-07 4.47E-06

Gm10637 10.07836958 0 20.15673916 Inf Inf 1.26E-07 4.6E-06

Efhc2 215.7912566 143.311839 288.2706742 2.011492394 1.008266283 1.29E-07 4.68E-06

Pcx 3795.335997 2996.759749 4593.912244 1.532959806 0.61631987 1.32E-07 4.78E-06

Cacnb3 875.6539729 1072.365606 678.9423402 0.633125808 -0.65943589 1.37E-07 4.96E-06 Slco1a5 100.8632815 57.06472127 144.6618418 2.5350486 1.342013406 1.4E-07 5E-06

Ppib 749.6906897 572.7665795 926.6147999 1.617787827 0.69402241 1.41E-07 5.03E-06

Gm16702 34.7263956 57.82830863 11.62448257 0.201017164 -2.314609406 1.47E-07 5.24E-06

Smarca2 3547.650321 2881.310609 4213.990033 1.462525428 0.548461708 1.49E-07 5.29E-06

Trpc7 78.04395268 39.71657598 116.3713294 2.930044358 1.550922506 1.55E-07 5.47E-06

Plod1 603.5228162 751.859836 455.1857964 0.605413103 -0.724008195 1.57E-07 5.52E-06

Aldh1l2 869.1228351 1443.567304 294.6783664 0.204132059 -2.292425317 1.67E-07 5.85E-06 Xylb 86.9751408 126.8399166 47.11036504 0.371415926 -1.428892418 1.83E-07 6.35E-06

Ndrg4 601.7067035 769.6666097 433.7467973 0.563551532 -0.827380555 1.94E-07 6.72E-06

Eif4ebp1 188.7947725 290.8260113 86.76353367 0.298334847 -1.744995592 1.97E-07 6.79E-06

H2afy2 480.5338643 359.5649137 601.5028149 1.67286293 0.742319239 1.98E-07 6.81E-06

Apob 84.46422359 8.653871865 160.2745753 18.52056257 4.211056016 2.18E-07 7.46E-06

Scpep1 868.4443807 1061.644588 675.2441735 0.636035997 -0.652819677 2.2E-07 7.51E-06 Ccdc8 224.6802483 299.0733023 150.2871943 0.502509562 -0.992777045 2.24E-07 7.65E-06

Bcorl1 472.938204 348.6559039 597.2205041 1.71292239 0.776459786 2.46E-07 8.34E-06

Chd3 4478.929525 3649.95911 5307.899941 1.454235454 0.540260873 2.49E-07 8.43E-06

Strc 18.51875354 3.809979905 33.22752718 8.721181741 3.124523637 2.49E-07 8.43E-06

Raph1 333.1677521 424.8253197 241.5101846 0.568492916 -0.814785724 3.05E-07 1.02E-05

Nrp1 2221.026471 2653.747243 1788.305699 0.673879437 -0.569437591 3.05E-07 1.02E-05

Slc30a8 16504.30573 19389.02802 13619.58345 0.702437659 -0.509557903 3.08E-07 1.02E-05 Lamc2 361.9908679 461.8974772 262.0842585 0.567407859 -0.817541963 3.41E-07 1.13E-05

Maob 6411.589237 3564.594528 9258.583947 2.597373663 1.377053578 3.57E-07 1.17E-05

Dner 262.8581552 341.1382897 184.5780207 0.541065094 -0.886125924 3.58E-07 1.17E-05

BC003331 1363.733752 1088.993258 1638.474247 1.504577035 0.589357975 3.58E-07 1.17E-05

Rhbdl2 71.29454947 106.5837036 36.00539533 0.337813325 -1.565701858 3.62E-07 1.18E-05

Tollip 2395.581364 2851.852107 1939.310621 0.680017949 -0.556355268 3.78E-07 1.23E-05

Tph2 118.0492894 18.44401045 217.6545684 11.80082656 3.560816008 3.98E-07 1.29E-05 Jam3 429.3622288 542.0826978 316.6417599 0.584120765 -0.775661423 4E-07 1.3E-05

Col27a1 309.7184951 396.2763409 223.1606493 0.563144014 -0.828424182 4.22E-07 1.37E-05 Eif4e3 509.1284139 634.6326585 383.6241694 0.604482238 -0.726228148 4.35E-07 1.41E-05

Pde3b 3826.820341 2666.226826 4987.413857 1.870588731 0.903492402 4.35E-07 1.41E-05

C130021I20Rik 78.90022203 121.4669284 36.33351567 0.299122701 -1.741190693 4.6E-07 1.48E-05

Paics 1548.718051 1244.87872 1852.557382 1.488142862 0.573513033 4.7E-07 1.51E-05

F2rl1 118.788462 164.2477317 73.32919227 0.446454825 -1.163413894 4.73E-07 1.52E-05

Cox7b 897.2249694 708.7920725 1085.657866 1.53170148 0.615135151 4.8E-07 1.53E-05

Zdhhc2 3143.785709 3717.127454 2570.443965 0.69151354 -0.532170595 4.94E-07 1.58E-05 Tie1 602.9965494 745.7322962 460.2608027 0.617193066 -0.69620624 5.09E-07 1.62E-05

Abhd2 2278.58752 1686.752487 2870.422554 1.701744967 0.767014842 5.22E-07 1.66E-05

Akr1c19 845.6803212 568.4174525 1122.94319 1.975560717 0.982262187 5.43E-07 1.72E-05

Cbs 1718.292419 1159.701761 2276.883077 1.963335018 0.973306371 5.59E-07 1.77E-05

Stard13 721.1872293 889.6863152 552.6881434 0.621216865 -0.686831098 5.65E-07 1.79E-05

Rfx6 2277.716578 2690.920221 1864.512935 0.692890455 -0.529300813 6.3E-07 1.98E-05

Pex5l 931.6557798 1126.376302 736.9352572 0.654253162 -0.612079104 6.36E-07 2E-05 Itgb5 729.160146 895.1633515 563.1569404 0.629110809 -0.668613945 6.49E-07 2.03E-05

Arhgap36 1058.625718 396.1948089 1721.056626 4.343965613 2.119012683 6.53E-07 2.04E-05

Dnaic2 140.6190584 90.04698075 191.1911361 2.123237609 1.08626583 6.68E-07 2.08E-05

Ube3a 1076.530227 847.1306122 1305.929842 1.541592079 0.624421064 6.84E-07 2.12E-05

Unc13b 2229.596486 1792.549786 2666.643185 1.487625731 0.573011607 6.86E-07 2.12E-05

Ica1l 913.8911731 678.0132877 1149.769059 1.695791335 0.761958659 7.02E-07 2.17E-05

Gpr85 165.4677389 222.9820995 107.9533783 0.484134729 -1.046519507 7.05E-07 2.17E-05 Kcnk1 418.2482749 528.09364 308.4029098 0.58399285 -0.77597739 7.09E-07 2.18E-05

Lgals12 769.9300269 542.0282876 997.8317663 1.840921939 0.880428453 7.2E-07 2.21E-05

Crmp1 520.5274252 643.8519906 397.2028598 0.616916412 -0.696853068 7.42E-07 2.27E-05

Ndufa4 1357.422509 1093.073719 1621.771299 1.483679711 0.569179684 7.86E-07 2.4E-05

Hmox1 75.15952889 109.3026617 41.01639608 0.375255236 -1.414055894 8.06E-07 2.45E-05

Yars 1212.951727 1459.972768 965.9306853 0.6616087 -0.595949889 8.07E-07 2.45E-05 Ceacam12 19.21464603 4.329792329 34.09949973 7.875550867 2.977380839 8.22E-07 2.5E-05

Sash1 500.8315115 619.5695716 382.0934515 0.616707903 -0.697340759 8.69E-07 2.63E-05

Msi1 143.7940299 195.8007307 91.787329 0.468779298 -1.093019237 8.81E-07 2.66E-05

Tceal3 1120.199969 855.9373458 1384.462593 1.617481232 0.693748973 9.18E-07 2.76E-05

Lonrf2 503.0273522 651.3883818 354.6663227 0.544477508 -0.877055642 9.18E-07 2.76E-05

Camkk2 758.8236825 594.2673838 923.3799811 1.553812318 0.635812254 9.62E-07 2.89E-05

Diras2 102.8551945 46.74378393 158.9666052 3.400807376 1.765877293 9.64E-07 2.89E-05 Amotl2 456.5415987 571.157705 341.9254924 0.598653383 -0.740207162 9.66E-07 2.89E-05

Trp53i13 404.1078853 507.9738582 300.2419123 0.591057802 -0.75862887 1.04E-06 3.09E-05

Scml4 581.6508061 448.7904756 714.5111365 1.592081774 0.670914439 1.06E-06 3.12E-05

Col4a1 5121.304975 6013.101121 4229.508828 0.703382289 -0.507619087 1.07E-06 3.16E-05

Tmc7 60.75451869 97.60783476 23.90120262 0.244869714 -2.029913743 1.08E-06 3.17E-05

Grid2ip 17.06811627 31.09453649 3.04169606 0.097820917 -3.353713207 1.08E-06 3.17E-05

Med13l 1382.02684 1115.358747 1648.694934 1.478174567 0.563816657 1.11E-06 3.26E-05 Lpl 3166.520968 4042.762603 2290.279334 0.566513436 -0.819817921 1.12E-06 3.28E-05

Tfcp2l1 92.76362053 131.4334695 54.09377155 0.411567706 -1.28079831 1.13E-06 3.29E-05 Nbeal2 983.0568417 1181.107443 785.0062404 0.664635758 -0.589364182 1.14E-06 3.33E-05

Zfp92 511.280379 630.6886464 391.8721116 0.621340044 -0.686545058 1.16E-06 3.36E-05

H1f0 3204.594703 2640.703782 3768.485623 1.42707624 0.513062411 1.17E-06 3.4E-05

Cib3 20.29059882 36.12641141 4.454786226 0.123311064 -3.019625846 1.19E-06 3.44E-05

Zfp568 1218.347825 1460.034328 976.6613225 0.668930383 -0.58007202 1.22E-06 3.53E-05

Igfbp3 2016.619829 2406.656903 1626.582756 0.675868153 -0.565186259 1.23E-06 3.54E-05

Svopl 70.87168829 28.47263228 113.2707443 3.978232261 1.992127507 1.24E-06 3.58E-05 Jak1 4774.730251 3939.055542 5610.40496 1.42430207 0.510255149 1.26E-06 3.62E-05

Btbd11 92.79274443 53.05535098 132.5301379 2.497959875 1.320750303 1.32E-06 3.79E-05

Frmd4a 706.1731146 860.9834138 551.3628155 0.640387267 -0.642983472 1.33E-06 3.8E-05

Slc8a2 113.4981804 157.3955153 69.60084558 0.442203486 -1.177217696 1.36E-06 3.88E-05

Nebl 128.4174467 175.8173892 81.01750433 0.460804843 -1.117772217 1.37E-06 3.9E-05

Ube3c 3281.403823 2032.75503 4530.052617 2.228528549 1.156091443 1.38E-06 3.91E-05

Ebp 488.0097717 375.5468782 600.4726652 1.598928656 0.677105567 1.4E-06 3.96E-05 Mslnl 13.48369485 25.31377727 1.653612436 0.065324602 -3.936229751 1.43E-06 4.04E-05

Atp11b 1988.595399 1537.833505 2439.357293 1.586229774 0.665601768 1.44E-06 4.08E-05

1700025G04Rik252.9782467 326.0969365 179.859557 0.551552428 -0.858430068 1.47E-06 4.15E-05

Muc4 598.2931554 937.2241944 259.3621164 0.276734337 -1.85342643 1.49E-06 4.17E-05

Slc44a3 659.0146881 805.3571234 512.6722527 0.636577535 -0.651591849 1.57E-06 4.4E-05

Tgfbr1 1253.779903 1491.585929 1015.973877 0.681136673 -0.553983785 1.65E-06 4.6E-05

Rassf8 189.3043683 250.6784011 127.9303355 0.510336491 -0.970479292 1.66E-06 4.62E-05 Rtn4rl1 809.4401121 541.875132 1077.005092 1.987552166 0.990992726 1.67E-06 4.66E-05

Mgat2 1408.499174 1081.44661 1735.551737 1.604842736 0.682431929 1.71E-06 4.73E-05

Flt1 2044.256805 2422.749662 1665.763948 0.687550998 -0.540461368 1.73E-06 4.77E-05

Myo6 4444.645386 3517.407117 5371.883655 1.527228289 0.610915732 1.74E-06 4.8E-05

Kcnmb2 1821.804219 2158.100486 1485.507951 0.688340492 -0.538805715 1.77E-06 4.88E-05

Apold1 133.4422921 181.8991788 84.98540537 0.467211594 -1.097852018 1.83E-06 5.02E-05 Kalrn 313.8543429 395.3935722 232.3151137 0.587554098 -0.767206403 1.95E-06 5.33E-05

Pak1 391.294942 283.2189335 499.3709505 1.763197624 0.818194185 2.05E-06 5.59E-05

Clstn1 4944.934433 3742.207152 6147.661714 1.642790328 0.716148358 2.05E-06 5.6E-05

Ppp2r2b 222.1512281 156.7483916 287.5540647 1.834494516 0.875382592 2.09E-06 5.7E-05

Timm8b 383.0888907 286.8162653 479.361516 1.671319147 0.74098725 2.14E-06 5.81E-05

Pard6g 47.43856427 72.77876005 22.09836849 0.303637606 -1.719577612 2.15E-06 5.84E-05

Crhr1 31.00440705 51.13023767 10.87857643 0.212762094 -2.232686955 2.25E-06 6.08E-05 Prom1 703.1528641 972.7957318 433.5099964 0.445633119 -1.166071638 2.31E-06 6.24E-05

Met 1137.068239 912.2808887 1361.855589 1.492802936 0.578023729 2.37E-06 6.35E-05

Rab34 285.0417015 362.3655353 207.7178677 0.573227439 -0.802820426 2.74E-06 7.32E-05

Prkaa1 1891.799622 2224.485538 1559.113705 0.700887319 -0.512745573 2.75E-06 7.33E-05

Dbi 432.579373 331.2438822 533.9148639 1.611848226 0.688715904 2.76E-06 7.35E-05

Phactr3 74.27025562 107.5128711 41.02764012 0.381606776 -1.389841306 2.78E-06 7.41E-05

Qpct 92.86265435 130.6025007 55.12280804 0.422065487 -1.244461232 2.86E-06 7.61E-05 Cep78 296.8374483 374.0814473 219.5934493 0.587020423 -0.768517398 2.9E-06 7.7E-05

Podxl2 321.3868823 427.8880519 214.8857127 0.502200778 -0.99366383 2.95E-06 7.8E-05 Lonrf3 78.70815376 115.0089429 42.40736464 0.368731018 -1.439359311 3.05E-06 8.06E-05

Abhd15 822.7829316 1015.074425 630.4914381 0.621128286 -0.687036825 3.11E-06 8.17E-05

Tmprss6 89.43585562 52.87109385 126.0006174 2.383166457 1.252879723 3.15E-06 8.28E-05

Cdkn1a 572.297049 806.5383455 338.0557525 0.419144055 -1.254481929 3.16E-06 8.29E-05

Col11a2 411.3956688 510.4132533 312.3780843 0.612010135 -0.708372549 3.18E-06 8.32E-05

Cd276 369.8126371 460.212825 279.4124492 0.607137468 -0.719904887 3.35E-06 8.7E-05

Rhob 1010.350747 1338.822647 681.8788471 0.509312304 -0.973377524 3.4E-06 8.82E-05 Iglon5 50.82814991 77.46522905 24.19107077 0.312282957 -1.679074261 3.45E-06 8.93E-05

Tmbim6 7251.635201 6083.259717 8420.010685 1.384128095 0.468977464 3.47E-06 8.97E-05

Cntn1 817.8266441 1144.10452 491.5487679 0.429636243 -1.218812394 3.5E-06 9.02E-05

Lefty1 218.9866688 156.660913 281.3124246 1.795677168 0.844528001 3.62E-06 9.31E-05

Dapp1 191.2432494 249.7732568 132.7132421 0.531334875 -0.912306687 3.72E-06 9.53E-05

Rcbtb2 481.321786 371.8443535 590.7992185 1.588834718 0.667969053 3.79E-06 9.71E-05

Bahd1 1028.322706 831.7766074 1224.868805 1.472593475 0.558359214 3.88E-06 9.93E-05 Fbxl16 4428.132444 5174.272167 3681.992721 0.71159626 -0.490869167 3.98E-06 0.000101488

Lzts2 792.8332493 952.8356099 632.8308886 0.664155372 -0.590407312 4.13E-06 0.000105023

Creg1 2265.332174 2656.181713 1874.482636 0.705705723 -0.502861385 4.28E-06 0.000108464

Igsf11 100.8625579 139.6331806 62.09193521 0.444678943 -1.169164004 4.35E-06 0.000110081

Dgkb 133.5994083 74.36347472 192.8353419 2.593145931 1.374703397 4.49E-06 0.000113258

Itga10 166.3704807 220.7238753 112.0170862 0.507498729 -0.978523886 4.54E-06 0.000114067

Lamb2 553.8225934 677.7969888 429.848198 0.634184284 -0.657025969 4.74E-06 0.000118565 Dad1 2353.597743 1964.366146 2742.829339 1.396292308 0.481600995 4.81E-06 0.000120099

Gstm1 877.1660485 670.239799 1084.092298 1.617469299 0.693738329 4.91E-06 0.000122351

Mcc 846.7911857 680.7398748 1012.842497 1.487855397 0.573234319 5.1E-06 0.000125976

Calb1 651.1437499 792.1310021 510.1564978 0.644030465 -0.63479916 5.25E-06 0.000129442

Wnk2 438.8055504 539.9527566 337.6583442 0.62534794 -0.677268974 5.39E-06 0.000132622

Wdsub1 402.4190379 498.4392228 306.3988531 0.614716578 -0.702006703 5.42E-06 0.000133128 Abca7 2289.690854 2681.440493 1897.941215 0.707806577 -0.498572928 5.42E-06 0.000133128

Hexb 771.863122 925.4064579 618.3197861 0.668160224 -0.581733994 5.45E-06 0.000133503

Slc29a1 1654.895138 1953.007052 1356.783224 0.694714964 -0.525506922 5.62E-06 0.000137477

Stab2 30.00794702 49.06111394 10.9547801 0.22328845 -2.163019466 5.8E-06 0.000141906

Coro2a 313.4029928 227.8939327 398.9120529 1.750428579 0.807708198 5.87E-06 0.000143332

Prkcsh 2550.234159 2122.559967 2977.908351 1.402979608 0.48849404 5.91E-06 0.00014407

Plk3 364.2936622 456.0036705 272.583654 0.597766359 -0.742346387 5.96E-06 0.00014523 Cplx3 80.6769196 29.64072229 131.7131169 4.443654093 2.151746517 6.11E-06 0.000148234

Cds1 1030.616739 837.5593627 1223.674115 1.460999865 0.546956044 6.22E-06 0.000150814

4833439L19Rik7477.203564 6161.249509 8793.157619 1.427171162 0.513158369 6.71E-06 0.000162252

Fbrsl1 925.6219195 1102.727224 748.5166149 0.678786738 -0.558969718 6.75E-06 0.00016293

Icmt 1386.217645 1145.597987 1626.837304 1.420076958 0.505969115 6.8E-06 0.000163938

Ap1s2 5666.474085 4761.198377 6571.749793 1.380272207 0.464952813 6.9E-06 0.00016613

Zbtb5 548.5131388 434.8228763 662.2034013 1.522926776 0.606846578 7.12E-06 0.000171051 9430069I07Rik 37.43522993 17.05826508 57.81219477 3.389101675 1.760902919 7.14E-06 0.000171473

1700010B08Rik21.15450646 6.568479198 35.74053372 5.441218985 2.443929892 7.28E-06 0.000174394 Dusp26 176.7500225 230.9978289 122.5022161 0.530317608 -0.915071443 7.46E-06 0.000178463

Tagln2 2225.351101 1841.630642 2609.071561 1.416718153 0.502552772 7.61E-06 0.00018151

Blcap 641.9150635 776.9477095 506.8824175 0.652402229 -0.616166384 7.86E-06 0.000187354

Acsl3 428.9801519 333.4846836 524.4756201 1.572712769 0.653255209 8.63E-06 0.000202842

Enoph1 542.7667506 432.1366109 653.3968903 1.512014659 0.596472126 8.65E-06 0.000203102

Epha7 119.0558971 171.6300323 66.4817618 0.387355062 -1.368271502 8.67E-06 0.000203327

Sema6b 150.5596557 198.2390742 102.8802371 0.518970528 -0.946275482 9.08E-06 0.000212148 Ascc1 604.4594602 481.6206292 727.2982911 1.510106185 0.594649998 9.22E-06 0.000214982

Slc25a23 1675.38086 1385.189565 1965.572155 1.418991454 0.504865901 9.28E-06 0.000216051

Fbln7 68.83135271 39.29097013 98.37173529 2.503672853 1.324046062 9.58E-06 0.000222472

Nek5 52.69295954 78.48045503 26.90546405 0.342830123 -1.544434217 9.61E-06 0.000223007

4930578M01Rik67.31672294 97.51607258 37.1173733 0.380628263 -1.393545405 9.66E-06 0.000223729

Upb1 1058.51508 863.1458656 1253.884295 1.452691074 0.538727936 9.8E-06 0.000226797

Larp1b 701.9592144 566.317145 837.6012838 1.479032184 0.564653446 9.86E-06 0.00022783 Dcaf12l1 448.8835627 547.6269062 350.1402193 0.639377312 -0.645260543 9.93E-06 0.000229146

Csf1 292.0303776 364.5178358 219.5429194 0.602283065 -0.731486401 9.94E-06 0.000229146

Lrba 2460.644317 2041.036748 2880.251886 1.411171009 0.496892827 1.01E-05 0.000231573

Klf10 576.6649683 377.553894 775.7760427 2.054742528 1.038957627 1.02E-05 0.000234013

Hspa8 3274.091315 2273.340311 4274.84232 1.880423401 0.91105754 1.03E-05 0.000237057

Myo1e 479.5664234 359.2438885 599.8889583 1.669865452 0.739731864 1.03E-05 0.000237057

Arhgap26 897.3646973 610.7999143 1183.92948 1.938326206 0.954811386 1.1E-05 0.000250279 Dym 594.2296353 473.4013262 715.0579444 1.510468824 0.594996407 1.11E-05 0.00025206

BC005561 347.8179747 257.9700752 437.6658743 1.69657614 0.762626178 1.12E-05 0.000254501

Paqr8 90.76655596 125.4232083 56.10990366 0.447364602 -1.160476988 1.22E-05 0.000275222

Higd1a 198.4747106 144.4078863 252.5415348 1.748807086 0.806371152 1.25E-05 0.000281834

Sertad4 109.7679522 148.1414671 71.39443728 0.481934185 -1.053091955 1.27E-05 0.000284836

Adamts17 91.322634 126.044927 56.60034099 0.449048941 -1.155055405 1.28E-05 0.000286907 Dll1 130.9621141 173.9458055 87.97842275 0.505780651 -0.983416248 1.32E-05 0.000294535

Spag9 2948.769581 2463.530346 3434.008816 1.393938103 0.4791665 1.33E-05 0.00029773

Xpr1 1323.767188 1074.688295 1572.84608 1.463536997 0.549459216 1.34E-05 0.000299145

Gabbr1 1003.201221 1181.555677 824.8467652 0.698102325 -0.518489579 1.38E-05 0.000305857

Ccdc162 334.2039419 186.2673676 482.1405162 2.588432544 1.372078721 1.4E-05 0.000310393

Mreg 411.3894589 505.7418741 317.0370438 0.626875211 -0.673749815 1.4E-05 0.000310393

Kcnip2 26.25379023 43.21884088 9.288739572 0.214923385 -2.21810563 1.41E-05 0.000311387 Fam169a 412.6973284 504.6399935 320.7546633 0.635610866 -0.653784307 1.43E-05 0.000316133

Mansc1 97.93768091 134.0489554 61.82640639 0.46122259 -1.116464919 1.56E-05 0.000342002

Fibin 134.1053594 78.76351402 189.4472048 2.405266032 1.26619647 1.57E-05 0.000345269

Camta1 691.6284908 548.8927757 834.3642059 1.520085967 0.604152916 1.58E-05 0.000345288

Tmem8 2235.283688 1858.446111 2612.121265 1.405540494 0.491125019 1.61E-05 0.00035159

Tshz1 3474.084863 2509.093115 4439.07661 1.769195644 0.823093595 1.65E-05 0.000359217

Marcks 1865.782255 2175.48401 1556.080499 0.715280136 -0.483419717 1.65E-05 0.00035953 2900005J15Rik206.3987904 261.0568783 151.7407024 0.581255332 -0.78275605 1.66E-05 0.000360309

5330413P13Rik53.00951965 78.53383895 27.48520035 0.349979075 -1.514659426 1.66E-05 0.000360753 Xrcc6 723.7095101 866.2246846 581.1943356 0.67095102 -0.575720643 1.66E-05 0.00036146

Fam160a1 234.6355517 296.5756891 172.6954144 0.582297945 -0.780170567 1.68E-05 0.000363749

Stag2 3632.264806 3047.61499 4216.914621 1.383676952 0.468507156 1.71E-05 0.000368889

Impact 1487.421223 1745.548965 1229.293482 0.704244628 -0.50585144 1.73E-05 0.000371788

Kif12 5805.382326 6677.658294 4933.106358 0.738747947 -0.436845878 1.73E-05 0.000371788

Rell1 368.3462097 281.7544518 454.9379675 1.614661151 0.691231437 1.74E-05 0.000373736

Kcnk16 1561.93789 2215.265693 908.6100876 0.410158515 -1.285746515 1.74E-05 0.000373736 Ubr4 14172.30068 8198.573265 20146.0281 2.457260239 1.297050656 1.76E-05 0.000376597

Vat1 1503.436379 1764.590251 1242.282508 0.704006217 -0.506339926 1.79E-05 0.000382886

Sec14l1 2210.955981 2568.80844 1853.103523 0.721386419 -0.471155831 1.84E-05 0.000391694

Stard5 331.2338487 411.9109307 250.5567668 0.608278995 -0.71719491 1.88E-05 0.000401536

Nav2 2884.540818 3386.371898 2382.709738 0.703617266 -0.507137209 1.89E-05 0.000402076

Asns 1526.918896 2035.551505 1018.286287 0.500250809 -0.9992765 1.98E-05 0.000419227

Crabp1 8.414603895 0.536941718 16.29226607 30.3427086 4.923277971 1.98E-05 0.000419227 Zfp365 334.2941736 449.7337794 218.8545679 0.486631376 -1.039098753 2E-05 0.000423397

Stx3 655.1416978 780.7889186 529.494477 0.678153166 -0.560316942 2.01E-05 0.000424478

Vtn 562.61104 690.0969014 435.1251786 0.630527652 -0.665368454 2.1E-05 0.000442703

Ngfr 414.7245777 117.5138348 711.9353206 6.058310684 2.598915565 2.14E-05 0.000451521

Rims3 1432.465138 1093.241279 1771.688996 1.620583699 0.696513534 2.16E-05 0.000453594

Glt28d2 71.14815685 100.4359869 41.86032678 0.416786135 -1.26262081 2.22E-05 0.00046343

Npc2 2792.459879 3246.888174 2338.031584 0.720083803 -0.473763279 2.24E-05 0.000467346 Tmem108 211.2347952 116.2383919 306.2311985 2.634509937 1.397534622 2.27E-05 0.000472498

Frmd4b 400.8350527 499.2703101 302.3997953 0.605683513 -0.723363954 2.32E-05 0.00048138

Moxd1 328.2147654 13.86101364 642.5685171 46.35797451 5.534745628 2.37E-05 0.000492205

4933417E11Rik32.65118317 51.48448812 13.81787822 0.268389154 -1.897601723 2.54E-05 0.000522767

Palm 201.6849241 256.6203273 146.7495209 0.571854625 -0.806279659 2.55E-05 0.000523718

Trim24 837.1366108 683.9217086 990.351513 1.448048074 0.5341095 2.73E-05 0.000559071 Prkar1b 1785.366987 2084.223205 1486.510769 0.713220525 -0.487579873 2.76E-05 0.000563738

1810019D21Rik128.5096975 79.52094024 177.4984548 2.232097033 1.158399745 2.79E-05 0.000567772

Hars 784.1358745 642.3548162 925.9169328 1.441441567 0.527512354 2.79E-05 0.000567772

Cdon 1319.519675 1099.94357 1539.09578 1.399249764 0.484653504 2.85E-05 0.000579424

Gdap1l1 819.4050817 972.2276489 666.5825145 0.685623902 -0.544510689 2.86E-05 0.000579984

Fkbp1a 2390.241154 2773.474965 2007.007343 0.723643576 -0.466648808 2.9E-05 0.00058628

Mapk3 3016.062389 3493.289607 2538.835171 0.72677489 -0.460419519 2.91E-05 0.000588835 Dtx3 2178.404321 2527.14596 1829.662681 0.724003564 -0.465931296 2.94E-05 0.000593611

Gpx1 1149.571673 869.8385879 1429.304758 1.643183894 0.716493946 2.99E-05 0.000602175

Ergic2 904.4786472 745.4788073 1063.478487 1.426571053 0.512551605 3E-05 0.000604866

Rhobtb1 1919.28262 2412.56267 1426.00257 0.591073794 -0.758589837 3.04E-05 0.000610492

Wdr1 2020.161361 1697.92116 2342.401562 1.379570275 0.464218949 3.07E-05 0.000616764

Napa 3110.729346 3600.384028 2621.074664 0.727998637 -0.457992346 3.13E-05 0.000628111

Gde1 2783.889243 2281.343294 3286.435191 1.440570211 0.526639977 3.17E-05 0.000634842 Pigh 310.5686208 236.5038411 384.6334004 1.626330459 0.701620433 3.19E-05 0.000636379

Mrap2 27.25905666 44.30857216 10.20954116 0.230419096 -2.117667808 3.21E-05 0.000639725 Tars 1078.768835 1266.390903 891.1467677 0.703690121 -0.506987835 3.26E-05 0.000647802

Fut8 626.2556494 504.3110296 748.2002692 1.483608776 0.569110707 3.26E-05 0.000648693

Rnf112 171.953742 222.8540918 121.0533922 0.543195735 -0.880455942 3.33E-05 0.000662192

Zfhx2 3235.57419 2731.133176 3740.015205 1.369400525 0.45354447 3.35E-05 0.0006641

Ahcyl2 2528.760742 2133.015142 2924.506343 1.371066846 0.455298911 3.46E-05 0.000683823

Apba1 637.7604934 758.844949 516.6760379 0.680871683 -0.55454516 3.5E-05 0.000688624

Shc4 125.1266362 84.90748671 165.3457857 1.947364032 0.961522601 3.53E-05 0.000693401 Tnr 400.7040634 499.128398 302.2797288 0.605615168 -0.723526755 3.55E-05 0.000696103

Gpr161 123.553183 162.981022 84.12534407 0.516166502 -0.954091577 3.79E-05 0.000740725

Rin2 358.4609376 439.8651525 277.0567227 0.629867406 -0.666879937 4.02E-05 0.000785178

AI661453 192.5831081 245.3448356 139.8213806 0.569897386 -0.811225919 4.11E-05 0.000800455

Srbd1 426.5724595 338.6804089 514.46451 1.519026482 0.603147021 4.14E-05 0.000804577

Dgke 962.3630825 1124.396688 800.3294773 0.711785695 -0.490485157 4.15E-05 0.000805202

Htr1d 25.31755301 9.616858696 41.01824733 4.265243841 2.092628222 4.19E-05 0.000810677 Cyb561d1 514.8015261 411.4661541 618.1368981 1.502278843 0.587152622 4.38E-05 0.000842887

Slc43a3 795.1268356 1023.462039 566.7916323 0.553798393 -0.852567228 4.43E-05 0.000849431

Ubash3b 95.94219387 61.29788081 130.5865069 2.130359243 1.091096733 4.48E-05 0.000858513

Gss 336.4174631 262.774196 410.0607301 1.560506078 0.642013977 4.58E-05 0.000876119

Tmed8 3468.593674 3977.014415 2960.172932 0.744320393 -0.426004331 4.6E-05 0.000879131

Tubb4b 1697.384107 1432.992565 1961.775649 1.36900616 0.453128938 4.61E-05 0.000880292

Tmem19 648.660394 526.8371949 770.4835932 1.462470001 0.548407032 4.77E-05 0.000906175 Mllt11 639.166922 523.6708132 754.6630308 1.441101951 0.527172403 4.81E-05 0.000911585

H6pd 492.7665623 589.0085425 396.5245821 0.673206844 -0.570878251 4.82E-05 0.000911585

Eef1a2 697.4324729 852.6452004 542.2197454 0.635926579 -0.653067886 4.93E-05 0.000931362

Sall1 312.1573269 198.5786125 425.7360414 2.14391689 1.10024898 4.96E-05 0.000935259

Gfra4 25.4058297 10.06331059 40.74834881 4.049199161 2.017636604 5.04E-05 0.00094962

Birc6 3130.933436 2651.890733 3609.97614 1.361283893 0.444967969 5.12E-05 0.000964641 B630019K06Rik1373.341646 836.2327069 1910.450585 2.284592039 1.191936565 5.19E-05 0.000975069

Sncb 240.7474033 300.5452428 180.9495637 0.602070963 -0.731994555 5.24E-05 0.000985038

Enah 1350.534373 1593.823801 1107.244945 0.694709756 -0.525517737 5.31E-05 0.000995852

Rbm20 279.4738676 94.21607263 464.7316626 4.932615525 2.30235284 5.67E-05 0.001058405

Slc8a1 1083.250041 1258.884058 907.6160242 0.720968717 -0.471991433 5.69E-05 0.001061786

Nkx2-2 1229.842434 1556.431334 903.2535342 0.580336257 -0.78503903 5.77E-05 0.001074629

Copz1 2688.392256 2307.789531 3068.994982 1.329841799 0.41125463 5.83E-05 0.001085507 Heg1 697.6801217 822.5299221 572.8303213 0.696424903 -0.521960302 5.84E-05 0.001085507

Ptprt 303.5355999 385.4741171 221.5970826 0.574868902 -0.798695105 6.02E-05 0.001116874

Aﬀ4 5011.531367 4283.174432 5739.888303 1.340101459 0.422342231 6.07E-05 0.001123017

Kdr 2963.767653 3397.769938 2529.765367 0.74453698 -0.425584588 6.19E-05 0.001142241

Gal 71.69962157 116.9310177 26.46822546 0.226357608 -2.143324298 6.22E-05 0.001146647

Trh 23.06772964 8.668144762 37.46731453 4.322414491 2.111837424 6.38E-05 0.001173365

Adi1 2510.709049 2889.464397 2131.953701 0.737836986 -0.438625986 6.45E-05 0.001185988 Mbd6 2554.857176 2953.001985 2156.712366 0.730345722 -0.453348545 6.53E-05 0.001196823

Ms4a4c 26.76321807 10.52845765 42.9979785 4.083976965 2.029974729 6.55E-05 0.001198145 Lpin2 494.261313 623.9239812 364.5986449 0.58436389 -0.775061063 6.55E-05 0.001198145

Ptprn2 15623.831 17790.05128 13457.61071 0.756468349 -0.402648375 6.69E-05 0.001221864

Lrpprc 1208.14287 1403.88603 1012.399709 0.721140953 -0.471646822 6.84E-05 0.001245712

Efcab10 39.63457702 20.14574652 59.12340752 2.934783651 1.553254153 6.94E-05 0.001262902

Sdhd 1769.046878 1503.599052 2034.494704 1.353083258 0.436250614 6.94E-05 0.001262902

Syt11 772.6652726 911.0285518 634.3019933 0.696248204 -0.522326393 6.96E-05 0.00126446

Tmem229a 64.34541222 90.98298765 37.7078368 0.414449314 -1.270732421 6.97E-05 0.001265281 Pamr1 1066.304297 895.804642 1236.803952 1.380662584 0.465360787 7.02E-05 0.001273156

Rcan3 3612.827492 4134.710838 3090.944146 0.74755993 -0.419738853 7.06E-05 0.001278279

Mirg 363.0539615 443.5655263 282.5423967 0.636980063 -0.650679878 7.14E-05 0.001289735

Hist1h4c 32.2641746 14.33515097 50.19319823 3.501407018 1.807934776 7.18E-05 0.001296342

Pdia4 4718.260478 3560.934751 5875.586205 1.650012319 0.722476795 7.27E-05 0.00131147

Hspa2 333.6060489 404.9620361 262.2500618 0.647591721 -0.626843553 7.35E-05 0.001321955

Zp2 21.76190469 35.66125528 7.862554111 0.220478894 -2.181287541 7.39E-05 0.001327599 Ripply3 867.6106086 512.0361732 1223.185044 2.388864514 1.256325033 7.41E-05 0.001329869

Cbx4 641.6100456 502.0744573 781.145634 1.555836236 0.637690214 7.57E-05 0.001357195

Tanc1 473.3034044 566.6272408 379.9795679 0.670598836 -0.576478117 7.62E-05 0.001366157

Iﬀo1 877.4822109 1025.394746 729.569676 0.711501282 -0.491061739 7.69E-05 0.001375755

Ldhb 321.8633464 249.7524016 393.9742912 1.577459471 0.657602939 7.8E-05 0.001392469

Ttc39c 98.49055233 65.39360307 131.5875016 2.012238131 1.008801045 7.97E-05 0.001420867

Tln2 860.3836071 625.1167 1095.650514 1.752713556 0.809590237 8E-05 0.001426174 Ube2m 765.9725755 637.2968671 894.6482839 1.403817169 0.489355054 8.11E-05 0.001437791

Gale 621.0228122 506.6595319 735.3860926 1.451440359 0.537485291 8.11E-05 0.001437791

Syde2 151.7677931 193.016369 110.5192171 0.572589867 -0.804425955 8.22E-05 0.001456083

Zdhhc22 40.68564457 76.71408249 4.657206659 0.060708628 -4.041954632 8.31E-05 0.001470818

Prnp 8959.358708 10216.88481 7701.832602 0.753833751 -0.407681706 8.5E-05 0.001501697

Tmem63c 272.2688494 335.5856397 208.9520592 0.622648989 -0.683509006 8.62E-05 0.001520369 Pde1b 171.6791804 126.1672492 217.1911116 1.721453967 0.783627602 8.9E-05 0.001562506

Terf2 1011.781276 1175.830553 847.731999 0.720964425 -0.472000021 8.92E-05 0.00156553

Adamts10 286.682549 351.4038744 221.9612236 0.631641367 -0.662822437 8.99E-05 0.001576532

Plp2 109.1781727 74.24686532 144.1094801 1.940950362 0.956763223 9.02E-05 0.001580488

Igfbp4 856.8288028 611.1956179 1102.461988 1.803779274 0.851022808 9.19E-05 0.001607869

Insc 24.73702079 10.37560271 39.09843888 3.76830532 1.913915861 9.23E-05 0.001611908

Svil 1071.768069 896.536474 1246.999665 1.3909079 0.476026894 9.29E-05 0.001621075 Prkdc 660.0761001 540.5995888 779.5526115 1.442014807 0.528085978 9.3E-05 0.001621075

Slc40a1 1686.23732 1141.266538 2231.208101 1.955028056 0.967189311 9.42E-05 0.001639535

Prkce 1032.912068 1198.892756 866.9313803 0.723110033 -0.467712902 9.45E-05 0.001641992

Hpcal1 705.2833824 582.6296576 827.9371073 1.421034952 0.506942039 9.55E-05 0.001656208

Krt18 2016.316911 1579.842921 2452.790901 1.552553655 0.634643127 9.56E-05 0.001656208

Hexa 2631.579434 3019.590143 2243.568724 0.743004387 -0.428557366 9.56E-05 0.001656208

Tmem63a 2598.820467 2214.670384 2982.970549 1.346914001 0.429657739 9.59E-05 0.001658019 Cib2 238.3642559 295.7314534 180.9970583 0.612031815 -0.708321444 9.6E-05 0.001658019

Dock9 1236.547372 1427.099557 1045.995187 0.732951799 -0.44820977 9.68E-05 0.001671703 Gm2694 13.96608127 3.866641316 24.06552121 6.223882498 2.637814824 9.75E-05 0.001677248

Gjb5 8.942311118 1.088156333 16.7964659 15.43571029 3.948199967 9.86E-05 0.001692596

Slc4a4 282.744982 202.3152591 363.1747048 1.795092997 0.844058586 0.0001005150.001718561

Pgm2l1 246.3025326 303.7054997 188.8995655 0.621982696 -0.685053651 0.0001008010.001721946

Lrrc38 10.99457159 20.24808302 1.741060154 0.085986419 -3.539747374 0.00010165 0.001731875

Crocc 768.9093832 898.1684095 639.6503568 0.71217196 -0.48970246 0.0001031180.001752287

Hsd3b2 12.13521772 2.525710678 21.74472476 8.609349025 3.105904156 0.0001040410.001764888 Ankrd55 461.0029848 185.4327207 736.5732489 3.972185956 1.989933164 0.0001049820.001776196

Shroom3 1034.399303 1202.15302 866.6455861 0.720911208 -0.472106515 0.0001052770.0017781

Slc5a9 62.87612615 37.30876524 88.44348705 2.370581993 1.245241294 0.0001061980.001790544

Lmtk3 1444.64379 1672.014315 1217.273264 0.728028016 -0.457934126 0.0001088660.00182821

Rer1 1244.44474 1048.321799 1440.567681 1.37416553 0.458555799 0.0001089030.00182821

Vsig1 37.8818632 19.37601619 56.38771021 2.910180796 1.541108784 0.0001096030.001838374

Fnip1 1609.552487 1849.838503 1369.266471 0.740208655 -0.43399609 0.0001101160.001845384 Aars 2423.255159 2897.339372 1949.170945 0.672745127 -0.571868058 0.0001103440.00184762

Cpt2 755.046872 881.9809389 628.1128051 0.712161428 -0.489723796 0.0001137690.001901447

Elovl2 975.622179 618.2000019 1333.044356 2.156331854 1.108579222 0.0001161130.001932571

Kcnma1 1141.598851 959.4768555 1323.720847 1.379627699 0.464279 0.0001165750.001938588

Prkab1 735.6413849 607.7084771 863.5742927 1.42103381 0.50694088 0.0001170920.001945536

Egﬂ7 498.8905734 592.4501903 405.3309565 0.684160396 -0.547593503 0.00011799 0.001955442

Plod2 252.2322061 193.4314369 311.0329752 1.607975313 0.685245257 0.0001184750.001960874 Tsku 61.95636655 86.35360116 37.55913195 0.434945752 -1.201092622 0.00011852 0.001960874

Gatm 558.9717906 766.410772 351.5328092 0.45867415 -1.124458494 0.0001236370.002036865

Abcb7 933.0800037 779.3559141 1086.804093 1.394490083 0.479737675 0.0001271080.002090511

Lipa 432.9416695 348.3322226 517.5511165 1.485797417 0.571237423 0.0001277050.002098556

Zc3h3 594.1577652 397.8477635 790.4677669 1.986859898 0.990490146 0.0001293450.002122053

Ptprr 431.1371434 513.5947319 348.6795549 0.678900178 -0.558728631 0.0001293540.002122053 Eci2 842.5268082 984.4878247 700.5657917 0.711604323 -0.490852821 0.0001306620.00213991

Cryz 211.515418 264.1937698 158.8370662 0.601214277 -0.734048826 0.0001334760.002184036

Slc12a6 2257.170563 1913.662582 2600.678543 1.359005798 0.442551611 0.0001335810.002184036

Prlr 11018.7356 7346.448834 14691.02236 1.999744732 0.999815852 0.0001352080.00220692

Tmem144 37.46696679 56.06591908 18.8680145 0.336532689 -1.571181448 0.0001374250.002239354

Ctns 620.2877259 731.370302 509.2051497 0.696234381 -0.522355036 0.0001378530.002244447

Tbc1d4 431.0791813 332.4497563 529.7086064 1.59334936 0.672062628 0.0001382230.002248577 Fmo4 85.495113 52.29306324 118.6971628 2.26984528 1.182593962 0.0001414940.002297952

Sobp 575.6739605 680.9207158 470.4272051 0.690869281 -0.533515331 0.0001416990.002299354

Klf6 554.6036785 675.5674309 433.6399261 0.641889923 -0.639602183 0.0001444630.002330591

0610040F04Rik8.854194397 1.352347139 16.35604166 12.09455855 3.596286207 0.0001449020.002335433

Grhpr 289.6078389 226.4426723 352.7730055 1.557891019 0.639594314 0.0001482170.002375865

Nova2 385.0462533 460.2406744 309.8518321 0.673238697 -0.570809991 0.0001499450.002399114

Angel1 370.5379282 445.0774201 295.9984363 0.665049322 -0.588466757 0.0001503330.002403344 Rab8b 644.0691613 533.5185758 754.6197467 1.414420755 0.50021135 0.0001526490.002435679

Wnt4 2980.739579 2073.9814 3887.497759 1.874413029 0.906438888 0.0001532020.002441184 Ppil1 228.4961338 174.3330331 282.6592345 1.621375074 0.697217869 0.0001587980.002513878

Tspan8 528.1289839 625.2217906 431.0361773 0.689413235 -0.5365591 0.0001647090.002598867

Sdcbp2 55.08744581 77.72700272 32.44788891 0.41745967 -1.260291267 0.0001648360.002598867

Ctnna2 152.0335956 194.9724725 109.0947187 0.559539084 -0.837689187 0.0001653090.002603204

Cdca3 62.87757577 35.26290469 90.49224685 2.566216472 1.359642873 0.0001681330.002644418

Bche 61.86463217 86.19817423 37.53109011 0.435404699 -1.199571117 0.00016883 0.002653057

Cd81 2190.63386 1883.719716 2497.548003 1.325859671 0.406928088 0.0001689550.002653057 Fnip2 1167.146214 1569.187707 765.1047213 0.487580114 -1.036288808 0.0001697150.002660688

Arhgap29 931.9072216 1079.471111 784.3433327 0.726599651 -0.460767421 0.0001700580.002663919

Poc1b 617.4797794 506.7881906 728.1713681 1.436835707 0.522895108 0.0001724530.002697097

Morn4 487.0177894 396.6200352 577.4155436 1.455840584 0.541852387 0.0001753140.002737439

Chac1 312.5864872 516.27282 108.9001544 0.210935285 -2.245127648 0.0001761910.002748917

Atp6v0e2 1696.144053 1451.66249 1940.625616 1.336829758 0.418815753 0.0001770950.002760143

Nedd4l 806.8268262 933.7655698 679.8880826 0.72811432 -0.457763112 0.0001773360.002760143 Nr1h3 118.7398977 154.4951383 82.98465705 0.537134424 -0.896644912 0.0001798620.002794983

Trib3 78.7070877 125.5997384 31.81443702 0.253300185 -1.981079962 0.0001805090.002800547

Slc7a5 1944.486452 2474.016451 1414.956454 0.571926857 -0.80609744 0.0001814580.002808559

Pfkfb2 6305.096261 5387.706279 7222.486242 1.340549367 0.422824349 0.0001829790.002829381

Lrch2 132.5624227 168.9901475 96.13469787 0.568877531 -0.813809995 0.0001830950.002829381

Ezr 1206.765609 1021.890048 1391.64117 1.361830633 0.44554729 0.0001840470.002841835

Cdkl1 421.1558559 225.2450304 617.0666813 2.739535164 1.453931122 0.0001854250.002858579 Chrd 76.63329321 120.3539339 32.91265249 0.273465531 -1.870569093 0.0001856820.002860261

Gcdh 606.3961048 489.3976912 723.3945184 1.478132266 0.56377537 0.0001861410.002865072

Kif1a 5055.375414 5707.421333 4403.329494 0.77150945 -0.374244267 0.00018825 0.002893591

Prdx2 1668.583356 1432.026321 1905.140392 1.330380848 0.411839305 0.0001883360.002893591

Cldn3 507.6867271 369.3900527 645.9834014 1.748783966 0.806352079 0.0001888670.002897852

Trpc5 19.16987319 6.752736328 31.58701004 4.677660804 2.22578725 0.0001891910.002900535 Thbd 1447.534227 1015.363855 1879.704599 1.851262077 0.888509147 0.00018997 0.002910186

Samd14 334.1581669 401.0544536 267.2618801 0.666397986 -0.585544054 0.0001904750.002915623

Cxxc4 1584.292594 1352.39659 1816.188598 1.342940829 0.42539574 0.0001920750.0029378

Twsg1 7959.487064 6912.055356 9006.918771 1.303073877 0.381918879 0.0001957160.002981749

Fgfr4 40.04340223 59.08731864 20.99948582 0.355397508 -1.492494528 0.0001978080.003008906

Abhd14b 860.3720689 723.6234792 997.1206586 1.377955093 0.462528872 0.00019969 0.003035162

Stk35 1124.266261 888.2216992 1360.310822 1.5314992 0.614944613 0.0002007 0.00304247 Cgrrf1 498.0633695 406.8953065 589.2314325 1.448115579 0.534176754 0.0002007250.00304247

D930016D06Rik485.4751595 395.4539685 575.4963504 1.455280251 0.541297007 0.0002062950.003116072

Entpd3 4392.641773 3695.624642 5089.658904 1.377212081 0.461750742 0.0002084250.003145792

Gabbr2 1180.035225 622.4149806 1737.655469 2.791795704 1.481193373 0.0002120430.003192956

Stc2 56.17462866 78.80330329 33.54595402 0.425692231 -1.232117333 0.0002124980.003197332

Msra 184.7740793 137.4735671 232.0745914 1.688139737 0.755434329 0.0002162850.003239273

Kcnh6 765.6405805 1020.301558 510.9796032 0.500812333 -0.997658005 0.0002174930.003250132 Slc16a5 30.1041144 47.75157641 12.45665239 0.260863689 -1.938631952 0.0002175110.003250132

Csgalnact1 162.628166 227.1064699 98.14986207 0.432175544 -1.210310661 0.0002187960.003263691 Ankfn1 7.007802954 0.536941718 13.47866419 25.10265779 4.649768215 0.0002189330.003263691

Slc7a1 819.6973877 1045.822288 593.572487 0.567565344 -0.817141595 0.0002217190.003292884

Nek6 113.889912 80.55244425 147.2273798 1.827720825 0.870045723 0.0002218130.003292884

Mapk8ip2 1538.956602 1765.386329 1312.526874 0.743478553 -0.427636969 0.0002223850.003295093

Cdhr1 888.4676451 1056.388844 720.5464464 0.682084491 -0.551977636 0.0002226960.003297193

Zfp330 632.2536687 530.1565023 734.3508352 1.385158594 0.470051167 0.0002257770.003340264

Anapc16 864.5733224 728.2631556 1000.883489 1.374343164 0.45874228 0.0002259490.003340264 Rragd 1249.654997 1431.501813 1067.80818 0.745935611 -0.422876992 0.0002305070.003399896

Cadm4 191.5793238 239.0773596 144.0812879 0.602655509 -0.730594533 0.0002329970.003431413

Arrdc4 692.5742536 429.8568351 955.2916721 2.222348452 1.152085041 0.0002362420.003468685

Tm9sf3 6563.788877 5732.280716 7395.297037 1.29011425 0.367498834 0.0002366130.003471518

Slc7a2 10482.8067 12521.67333 8443.940079 0.674345981 -0.568439123 0.0002387510.003497605

Creld2 2332.018352 1737.860019 2926.176686 1.683781578 0.751705003 0.0002422550.003539573

Tmem38a 577.9331668 458.9749708 696.8913629 1.518364633 0.602518293 0.0002423440.003539573 1700001D01Rik8.475644961 1.264283537 15.68700638 12.40782303 3.633178109 0.0002431970.00354936

Akt1 2113.457211 2413.955695 1812.958728 0.751032313 -0.413053115 0.0002447130.003568814

Arnt2 428.3455207 507.6073128 349.0837286 0.687704294 -0.540139741 0.0002457360.003581035

Xkr7 168.8254649 212.4250779 125.2258518 0.589505971 -0.762421669 0.0002459980.003582175

Atp2a3 16427.91293 18524.66039 14331.16547 0.773626353 -0.370291154 0.0002561640.003716287

Mapkap1 452.4508758 369.9958873 534.9058643 1.445707595 0.531775786 0.0002591780.003746034

Rgs16 827.1525201 642.7490179 1011.556022 1.573796294 0.654248816 0.0002602420.003755834 Sesn1 705.674657 825.6878436 585.6614704 0.709301311 -0.49552948 0.0002614440.003769444

Nﬁx 386.6418129 311.381122 461.9025039 1.483399189 0.568906886 0.0002615730.003769444

Scn3a 445.3427519 527.6331906 363.0523133 0.688077095 -0.539357874 0.0002678540.003854242

Afap1 161.1102594 210.7781459 111.442373 0.528718822 -0.919427409 0.0002732610.003923335

Slc12a7 1582.137984 2149.692007 1014.583961 0.471967127 -1.083241716 0.0002754060.003942489

Mpdu1 426.8769173 345.6406655 508.1131691 1.470061887 0.555876891 0.0002776980.003960711 Pnpla8 1778.316492 1536.000222 2020.632762 1.315515931 0.395628719 0.0002786180.003970913

Mpst 170.7733568 128.4252163 213.1214973 1.659498839 0.73074762 0.0002859260.004063157

Fbxl17 1674.24639 1434.895792 1913.596989 1.333613911 0.415341058 0.0002867040.004068264

Osbpl5 515.4875149 608.831641 422.1433888 0.693366376 -0.528310218 0.0002875170.004070893

Ampd2 2632.800292 3068.830626 2196.769958 0.71583291 -0.482305222 0.0002879860.004074564

Gjb3 12.97178989 2.948899395 22.99468038 7.797716131 2.963051636 0.0002893670.004091126

1700049E15Rik10.14869212 18.51822225 1.779161991 0.096076285 -3.379675829 0.0002901380.004099041 Sftpb 49.59803334 70.7781535 28.41791318 0.401506846 -1.316503508 0.0002927660.004127166

Pdap1 779.6040431 905.0569169 654.1511694 0.722773515 -0.468384453 0.0002945750.004149659

Skil 885.9095461 1024.296447 747.5226449 0.729791309 -0.454444125 0.0002955210.004159976

Kazn 260.6391143 314.9733007 206.3049278 0.654991796 -0.610451259 0.00029799 0.004188664

Cpne5 131.0937263 167.601985 94.58546749 0.564345747 -0.825348792 0.0002987010.004194441

Cnot1 2876.831789 2477.462556 3276.201022 1.322401831 0.403160628 0.0003133650.004370026

Rnf11 2773.792595 2409.352658 3138.232532 1.302521041 0.381306678 0.0003176620.004423603 Coro2b 1032.253871 1191.49609 873.0116525 0.732702071 -0.448701401 0.0003197040.004448852

Copz2 492.3908922 579.3209225 405.4608619 0.699889899 -0.514800108 0.0003214320.004469698 St8sia5 139.6851218 176.6410794 102.7291642 0.581570066 -0.781975081 0.0003235570.004496027

Sytl3 62.37446731 35.28003398 89.46890064 2.535964129 1.342534339 0.0003262640.00452718

Sars 2646.715604 3009.465204 2283.966004 0.758927534 -0.397965959 0.0003301410.004567928

Asah1 3448.278156 2996.899167 3899.657144 1.301230681 0.379876744 0.0003308090.004573922

Fgl2 901.6784458 746.7145632 1056.642328 1.415055204 0.500858336 0.0003320170.004584096

Eif5a2 270.3361892 326.7957325 213.8766459 0.654465847 -0.611610187 0.0003341650.004610484

Tcf4 1001.716942 1150.904117 852.5297675 0.740747865 -0.432945532 0.0003377940.004653938 Trim9 859.7988029 729.0124156 990.5851903 1.35880428 0.442337667 0.0003412540.00469829

Dbpht2 1723.354904 1958.423913 1488.285895 0.759940626 -0.396041389 0.0003419310.004704275

Adarb1 868.1559965 995.3969755 740.9150176 0.744341239 -0.425963927 0.0003436980.004721905

Btnl9 120.629907 155.6678145 85.59199946 0.549837484 -0.862922832 0.0003444010.004728211

Uchl1 434.4989086 601.773973 267.2238441 0.444060156 -1.171172967 0.0003521220.004823994

Lgi2 93.42595032 126.6797739 60.17212676 0.474993955 -1.074018943 0.0003562860.004874167

4930502A04Rik38.80538517 21.43857585 56.17219448 2.6201458 1.389647094 0.0003597540.004907705 Vps13b 1778.508348 1520.310484 2036.706212 1.33966465 0.421871904 0.0003604880.004910926

Evpl 290.4585133 352.3574044 228.5596223 0.648658491 -0.624468974 0.0003677390.004992217

Sema4a 574.4778127 466.8245713 682.131054 1.461214975 0.547168444 0.0003742120.005069464

Bcap31 1336.764446 1146.128009 1527.400883 1.332661684 0.414310577 0.0003777070.005109689

Usp1 622.3258716 517.5079269 727.1438164 1.405087301 0.490659771 0.0003826090.005168808

Podxl 1982.954382 2295.227729 1670.681035 0.727893365 -0.458200981 0.0003835910.005178479

Ciao1 772.8353557 652.9382327 892.7324786 1.367254105 0.451281393 0.0003850770.005192729 Mars 1314.742948 1567.701434 1061.784462 0.677287422 -0.562159892 0.0003854480.005192729

Ap3b2 2915.575498 2534.831153 3296.319842 1.300410025 0.378966583 0.0003888940.005231904

Slc2a4rg-ps 433.4196138 510.7874713 356.0517563 0.697064388 -0.52063617 0.0003909720.005254566

Fam46c 972.7154575 1199.384947 746.0459677 0.622023788 -0.684958342 0.00039312 0.005274158

Itgb8 311.6952641 221.3686479 402.0218804 1.816074156 0.860823114 0.0004012470.005379473

Npnt 814.474998 499.387625 1129.562371 2.261894998 1.177531958 0.0004042580.005416106 Dact1 214.3375167 276.9079242 151.7671091 0.548077884 -0.867547175 0.0004056390.005430871

Wwp1 395.4409194 322.2340119 468.647827 1.454371077 0.540395414 0.0004078850.005457181

Dcun1d3 483.7727527 566.3288005 401.2167049 0.708451883 -0.497258225 0.0004100080.005481517

Acadsb 1600.72485 1822.673524 1378.776177 0.756458114 -0.402667894 0.0004102680.005481517

Nrsn1 466.901039 386.2506027 547.5514753 1.417606785 0.503457415 0.0004399050.005829411

Rtn1 746.9446337 634.7949975 859.0942699 1.353341273 0.436525691 0.0004456770.005901054

Txnip 11483.07463 5862.514728 17103.63453 2.917456983 1.544711384 0.0004460570.005901054 Abcd2 71.63144857 98.59836126 44.66453587 0.452994708 -1.142433898 0.0004462220.005901054

Numbl 177.0896654 247.7971403 106.3821905 0.429311615 -1.219902889 0.0004521070.005974825

Kif3c 477.7925931 560.2546265 395.3305598 0.705626587 -0.503023175 0.00045906 0.00605025

Cyth1 714.8524088 828.7172254 600.9875922 0.725202245 -0.463544704 0.0004636640.006102662

Ociad2 1822.118919 2110.967638 1533.270201 0.726335247 -0.461292503 0.0004692020.006158943

Stmn3 309.3330105 381.9489533 236.7170677 0.619761006 -0.690216107 0.0004692080.006158943

Tmem184b 1758.434066 1997.55342 1519.314711 0.760587775 -0.394813344 0.0004706440.006167294 Arhgap44 722.8420687 834.4955655 611.1885719 0.732404817 -0.449286815 0.0004707950.006167294

Ube2o 1642.294458 1868.964067 1415.624849 0.757438238 -0.40079984 0.0004731830.006186059 Slc2a2 13220.35078 11530.21291 14910.48865 1.29316681 0.370908385 0.0004844950.00630707

Osmr 231.8189479 281.9265253 181.7113705 0.644534495 -0.633670523 0.0004874850.006327666

Plscr1 415.9654515 491.831917 340.0989861 0.691494339 -0.532210655 0.00048792 0.006327666

Tjp3 218.0520625 266.8042666 169.2998584 0.634547043 -0.65620097 0.0004883180.006328607

Adam15 755.4734294 874.9169801 636.0298786 0.726960264 -0.460051588 0.0004929510.006384392

Pygo1 40.44643683 58.07493996 22.81793369 0.39290499 -1.347747605 0.0004964220.006420787

Slc25a40 254.4868057 200.9192239 308.0543876 1.533225053 0.616569477 0.0005003680.006463231 Ramp1 243.0345958 140.9958268 345.0733648 2.447401265 1.291250659 0.0005061250.006533247

Snx8 395.731435 467.0692247 324.3936452 0.694530121 -0.525890831 0.0005157050.006644839

Tshz3 379.0736039 446.4383091 311.7088987 0.698212703 -0.518261489 0.00052176 0.006717232

Fbxl2 947.3408478 806.1832055 1088.49849 1.350187504 0.433159772 0.00052419 0.00673958

Trub1 534.807137 622.0246576 447.5896163 0.719568928 -0.474795204 0.0005253940.006742835

Apc 1964.460669 1695.614919 2233.306419 1.317107083 0.397372644 0.0005263720.006749777

Dct 43.0094158 61.28360791 24.73522369 0.403618921 -1.308934288 0.0005267610.006750321 Rbpjl 135.0319841 208.8098931 61.2540751 0.29334853 -1.769312335 0.0005294710.006776118

Thbs3 660.7175657 767.5579701 553.8771614 0.72160955 -0.470709663 0.0005311680.006788887

Maﬀ 120.7045318 155.7113478 85.69771592 0.550362688 -0.861545429 0.0005334660.006813785

Fhod1 298.9015904 361.5308224 236.2723583 0.653533098 -0.613667793 0.0005358190.006834853

Gpr39 93.78280109 64.88078489 122.6848173 1.890926836 0.919093543 0.0005382150.0068598

Lyve1 274.8933936 466.3225703 83.46421683 0.178983867 -2.482098542 0.0005460310.00694689

G6pc3 683.1762366 581.0543906 785.2980825 1.35150529 0.434567158 0.00056481 0.007143727 Cdc42se2 2521.352849 2129.454256 2913.251443 1.368074207 0.452146487 0.0005702760.007203487

Hist1h4n 18.31479503 7.059745827 29.56984424 4.188514001 2.066438496 0.0005732950.007236919

Anxa10 5.469667605 0.275607308 10.6637279 38.69174587 5.273953923 0.0005736810.007237093

Ptges 308.181338 222.6695412 393.6931349 1.768060116 0.822167329 0.0005903860.007404577

Flt3l 152.8670877 189.9328887 115.8012866 0.609695811 -0.713838462 0.0005984650.007501071

Rab37 1592.127946 1886.876539 1297.379353 0.687580415 -0.540399644 0.0006037570.007557658 Tns1 1335.828972 1532.446262 1139.211682 0.743394212 -0.427800639 0.0006060950.007582037

Dnajc16 623.3731357 523.5864209 723.1598506 1.381166168 0.465886901 0.0006071850.007590794

Abtb2 126.9649637 93.13074543 160.799182 1.726596102 0.787930636 0.00061106 0.00762452

Tmem176b 3198.768815 2799.974353 3597.563276 1.284855796 0.36160645 0.0006169240.00769275

Asb4 79.30113075 105.3960763 53.20618525 0.50482131 -0.986155284 0.0006263890.007805773

P2ry12 137.2736856 102.4818565 172.0655146 1.678985144 0.747589465 0.0006273480.007812716

Kctd20 883.2934046 1011.706693 754.8801159 0.746145223 -0.422471645 0.0006286430.007818828 Spred1 265.5383651 324.6737917 206.4029386 0.635724052 -0.653527422 0.0006313030.007843026

Wﬁkkn2 74.68079234 49.06397034 100.2976143 2.044221323 1.031551402 0.0006474580.008006735

Dnpep 1082.854445 935.8679235 1229.840966 1.314118088 0.394094923 0.00064891 0.008019584

Gjc2 68.93765436 44.59601706 93.27929165 2.09165073 1.064641966 0.0006521650.00804958

Cecr6 33.78735123 56.83477088 10.73993158 0.188967623 -2.403789023 0.0006560160.008077784

Syt10 7.132793595 0.98867623 13.27691096 13.42897762 3.747277568 0.0006561120.008077784

Gpr26 18.80095211 0 37.60190421 Inf Inf 0.0006573120.00808743 Pparg 53.45554264 74.76882864 32.14225665 0.429888461 -1.21796571 0.0006671960.008183153

Nell2 31.28237032 46.77719125 15.7875494 0.337505288 -1.567017989 0.0006701510.008209027 Ipcef1 61.5287765 87.62101641 35.43653658 0.404429645 -1.306039342 0.0006761060.008266355

Itga2 77.57674579 38.00384451 117.1496471 3.082573582 1.624135333 0.0006780430.008284825

Mgst3 108.0263686 138.4105892 77.64214799 0.56095526 -0.834042385 0.0006847650.008345976

Tmx2 408.1698883 336.9125819 479.4271948 1.423001754 0.50893744 0.0006853240.008347559

Sephs2 818.4159674 695.2620007 941.569934 1.354266353 0.437511512 0.00068648 0.008356395

Mgat1 1215.569519 1042.772381 1388.366658 1.331418709 0.412964346 0.0007017660.008510506

A330076H08Rik1422.237897 1236.931964 1607.54383 1.299621869 0.378091925 0.0007022660.008511251 Usp9x 6029.104625 4876.613183 7181.596067 1.472660594 0.558424969 0.0007104010.008604486

Gpld1 897.849201 1027.338372 768.3600299 0.747913298 -0.41905706 0.00071166 0.008614363

Hmbs 438.9669351 368.0492588 509.8846115 1.38537057 0.470271932 0.0007150050.008641188

Susd1 391.8552946 300.166887 483.5437023 1.610916204 0.687881451 0.0007182670.008656614

Pip5k1c 1720.464954 1948.636023 1492.293885 0.765814584 -0.38493296 0.0007289670.008763838

Csf2ra 940.316631 1075.415011 805.2182507 0.748751173 -0.417441738 0.0007352520.008828476

Ogdhl 2418.621454 2983.850796 1853.392112 0.621141015 -0.68700726 0.0007400350.008869469 Hist1h2ac 82.12334019 57.53401525 106.7126651 1.854775208 0.891244348 0.0007436190.008901533

Rnf114 1135.74218 1289.520083 981.9642776 0.761495917 -0.393091794 0.0007440840.008901533

Serinc2 226.6952587 274.1951091 179.1954082 0.653532475 -0.613669168 0.00075164 0.008975359

Tmem208 494.9056227 413.3851517 576.4260937 1.394404447 0.479649075 0.0007546020.009005192

Med13 2366.209834 2045.257751 2687.161916 1.31385001 0.393800586 0.0007706630.009168717

Akap17b 307.2972665 249.9745045 364.6200285 1.458628868 0.544612852 0.0007714830.00917286

Capn5 836.179375 640.9605675 1031.398183 1.609144516 0.6862939 0.0007731810.009181816 Cdh23 43.32825368 20.52083393 66.13567343 3.222855058 1.688339307 0.0007776560.009229318

Ccnb1 23.69281532 8.031722941 39.35390769 4.899808918 2.292725488 0.0007805280.009257763

Slc25a24 168.6024786 208.3544873 128.8504699 0.618419462 -0.693342373 0.0007846810.009301341

Esm1 1114.732428 1401.693049 827.771807 0.59055141 -0.759865436 0.0007966830.009432104

Hs6st3 81.1818289 105.645976 56.7176818 0.53686552 -0.897367345 0.0008026240.009490878

Tle2 1187.478329 999.5309169 1375.425742 1.376071234 0.460555154 0.0008035330.009495859 Tmem130 812.8547065 688.1036533 937.6057598 1.362593783 0.446355529 0.0008122 0.009586618

Cacna1d 2593.691558 2907.897114 2279.486003 0.783894998 -0.351267675 0.0008156750.00961596

Atp5g1 253.3839861 195.7094078 311.0585644 1.589389942 0.66847312 0.0008237570.009693611

Slc44a1 1254.494879 1079.653199 1429.33656 1.323884894 0.404777691 0.0008280090.009725974

Napepld 477.3326583 587.4067459 367.2585708 0.625220213 -0.677563674 0.0008364750.009819486

Zdhhc1 851.9385449 979.0673294 724.8097605 0.740306349 -0.433805693 0.0008472880.009910514

Gnai3 2275.318519 1990.757975 2559.879064 1.285881607 0.362757818 0.0008557440.009997266 Tpcn1 905.6896205 1052.965291 758.4139502 0.72026491 -0.473400475 0.0008579160.009998736

Col9a2 65.51419834 90.45390962 40.57448706 0.448565322 -1.156610004 0.0008761730.010180989

Banp 835.354432 955.2118818 715.4969823 0.749045312 -0.4168751 0.0008930320.010348081

Hhatl 84.00729456 113.1537578 54.86083137 0.484834375 -1.044436106 0.0008959010.010373024

Gca 300.3814869 357.039194 243.7237798 0.68262472 -0.550835435 0.0008983090.010394722

Syngr3 89.0555741 125.7359487 52.37519948 0.416549125 -1.263441446 0.0009186920.010605318

Vat1l 1024.090024 1161.628376 886.5516722 0.763197328 -0.389871975 0.0009203360.010605318 Fam196a 14.25919371 27.82434561 0.694041812 0.024943689 -5.325181368 0.0009208730.010605318

Casp6 132.0741094 164.8780197 99.27019915 0.602082675 -0.73196649 0.0009219320.010611226 Chd7 813.6290431 931.6406379 695.6174482 0.74665855 -0.421479451 0.0009225660.010612236

Hist1h2af 7.377124768 1.161947037 13.5923025 11.69786751 3.548173649 0.0009294330.01067228

Tmem45a 91.68626821 131.911781 51.46075539 0.390114931 -1.358028878 0.0009326030.010702364

Gpr155 300.1636274 391.8319008 208.495354 0.532104082 -0.910219623 0.0009357860.010732559

Gnai1 488.6615126 573.3997693 403.9232559 0.704435679 -0.505460112 0.0009485790.010860052

B3gnt3 192.1653726 275.3628965 108.9678486 0.395724515 -1.337431654 0.0009493090.010862022

Tcn2 1723.990265 1507.361882 1940.618648 1.287427174 0.364490825 0.0009607840.01098039 Hspg2 1978.141631 2231.664429 1724.618833 0.772794875 -0.371842569 0.0009746590.011119354

Ccbe1 83.14214784 56.81765067 109.466645 1.926630963 0.946080256 0.0009800220.011173975

Ghr 3848.050149 4329.332747 3366.767552 0.777664307 -0.36278057 0.0010018380.011395979

Ttc28 1565.472819 1856.037942 1274.907696 0.686897432 -0.541833404 0.0010036420.011403153

Cltc 10948.38569 9601.293725 12295.47766 1.280606345 0.356827063 0.0010087330.011454302

Plcxd3 88.46321217 128.465711 48.46071331 0.377226833 -1.406495793 0.0010096220.011457712

Rapgef4 2003.208231 2254.087653 1752.32881 0.777400474 -0.363270107 0.0010148290.011503364 Mrm1 259.7746528 210.1133422 309.4359633 1.47270973 0.558473104 0.0010183560.011536623

Coq10b 467.2433138 378.622513 555.8641146 1.468122194 0.553972051 0.0010229480.011581892

Cald1 764.9872122 878.7320242 651.2424002 0.741116043 -0.43222864 0.0010243120.011583845

Aldh18a1 1678.738015 2033.969599 1323.506431 0.650701186 -0.619932911 0.0010342460.011675804

Pycr1 306.4827855 394.0513672 218.9142037 0.555547378 -0.848018144 0.0010390020.011715895

Snx30 1007.187132 1141.517885 872.856379 0.764645382 -0.387137268 0.0010403490.011724277

Dmd 250.4750096 301.1379947 199.8120244 0.663523129 -0.59178134 0.0010538160.011841729 Dcdc2a 306.870992 392.2495134 221.4924706 0.564672391 -0.824514001 0.0010556650.011855647

Aurkaip1 534.8244825 452.9036369 616.7453281 1.361758391 0.445470757 0.00105756 0.011870069

Lrp4 131.191611 91.03852246 171.3446996 1.882112044 0.912352516 0.0010619590.011905696

Psme4 2005.460246 1750.037793 2260.882699 1.291905071 0.369500065 0.0010713940.012004554

Inpp5a 694.2939471 799.0563969 589.5314972 0.737784591 -0.438728436 0.00107955 0.012082009

Nedd9 500.3502726 418.3867419 582.3138032 1.391807495 0.476959682 0.0010830270.01211395 2010300C02Rik 310.802331 367.7499127 253.8547492 0.6902918 -0.534721748 0.0010837560.012115132

Galr3 148.5439886 112.8835697 184.2044074 1.631808843 0.706472064 0.0010867270.01214136

Rassf4 581.2782727 733.4861294 429.0704159 0.584974138 -0.773555252 0.0010894080.01216433

Prox1 788.8602965 931.4262217 646.2943713 0.693876075 -0.527250071 0.0010904830.01216934

Tob1 1954.991585 1703.003816 2206.979353 1.295933299 0.373991466 0.0011014260.012249269

B930025P03Rik4.120860615 0 8.241721231 Inf Inf 0.0011024030.012251681

Pcnx 2672.990872 2339.936934 3006.044811 1.284669158 0.361396869 0.0011029030.012251681 Slc27a1 622.466154 715.9464006 528.9859074 0.738862444 -0.436622295 0.0011040750.012257696

Xpo1 2283.779996 1989.396282 2578.16371 1.295952814 0.37401319 0.0011398530.012611696

Cep55 32.8600261 16.67374813 49.04630408 2.941528426 1.556565978 0.00115613 0.01278451

Lypd6b 14.18523275 5.085249764 23.28521573 4.578971892 2.195023709 0.0011636520.012853067

Prpf8 6748.252691 5943.162962 7553.34242 1.270929717 0.345884251 0.0011644380.012854443

Sytl4 12144.83854 9311.753798 14977.92329 1.608496489 0.685712787 0.0011739710.012944975

Fuca2 639.8154717 734.6241532 545.0067902 0.741885205 -0.430732126 0.0011751370.012950486 Zfp52 254.1372583 204.5714873 303.7030293 1.484581421 0.570056219 0.00119188 0.013120132

Mpp3 273.9302462 325.5628602 222.2976323 0.682810171 -0.550443546 0.0012080390.013267952 Nfkbiz 707.8378997 830.6229906 585.0528089 0.70435422 -0.505626951 0.0012130530.013300482

Hmgcs2 266.7821516 364.2037045 169.3605987 0.465016134 -1.104647322 0.0012172170.013338609

Ube2c 50.80412438 25.45235931 76.15588945 2.992095488 1.581156217 0.0012307210.013478996

Apobec1 261.2240171 389.4971548 132.9508794 0.341339796 -1.55071947 0.0012644120.013778908

Ranbp2 4322.993031 3811.533201 4834.452861 1.268374852 0.342981179 0.0012654770.013778908

Abcb8 686.415112 592.0217644 780.8084597 1.318884721 0.39931847 0.00127421 0.013846085

Cadps2 136.2328213 171.7954485 100.670194 0.585988714 -0.771055215 0.0012794680.013879948 Ubr3 3344.196772 2927.585587 3760.807957 1.284610764 0.36133129 0.0012805170.013883572

Rab11ﬁp1 370.7300583 433.1384994 308.3216173 0.711831476 -0.490392367 0.0012947090.014029624

Camk2b 4211.790422 4881.147262 3542.433582 0.725737904 -0.462479474 0.00130918 0.01413129

Erc2 320.9928067 410.064233 231.9213803 0.565573297 -0.822214088 0.0013177480.014207999

Ctdspl 1372.30189 1192.294889 1552.308891 1.30195047 0.380674565 0.0013205010.014229791

Diras1 70.57145172 92.69328382 48.44961962 0.522687487 -0.935979472 0.0013356340.014361024

Syt13 17997.95845 19995.09952 16000.81738 0.800236946 -0.321500857 0.0013383950.014363675 C1qbp 502.8795657 425.5043121 580.2548192 1.363687283 0.447512847 0.0013404710.014365912

Hist1h4d 18.24783046 7.622376943 28.87328397 3.787963281 1.921422346 0.0013454080.014410323

Dact3 64.72913344 86.45222999 43.00603688 0.497454339 -1.007363989 0.0013487270.014437911

Slc16a6 264.9566881 185.3397569 344.5736193 1.859145739 0.894639868 0.0013665670.014604767

2010204K13Rik96.86208034 70.79528279 122.9288779 1.736399277 0.796098727 0.0013708450.014642428

Tmem179 219.6353341 175.3592363 263.9114319 1.504975942 0.589740425 0.0013734 0.01466167

Osbpl3 221.2673107 265.1815493 177.3530721 0.668798687 -0.580356079 0.0013772610.014686759 Sdk2 830.1015587 707.1992757 953.0038416 1.347574686 0.430365233 0.0013789160.014696344

Cep350 1849.631272 1606.60327 2092.659273 1.302536421 0.381323713 0.0013990340.014894421

Nisch 9638.822764 10713.98112 8563.664412 0.799298068 -0.323194492 0.0014393750.015282061

Nudt9 418.1988151 351.4300121 484.967618 1.3799835 0.464651017 0.0014414450.015289792

Rbp7 383.5825893 516.491071 250.6741076 0.485340641 -1.042930422 0.0014416760.015289792

Pik3cg 132.8674019 71.86544039 193.8693634 2.697671681 1.431714776 0.0014490020.015359107 Txn2 891.8387258 772.9193778 1010.758074 1.307714754 0.387047886 0.0014512450.015374498

Kctd12 1213.339787 1370.258625 1056.420949 0.770964641 -0.375263399 0.0014917080.015768785

Atf4 3973.841957 4442.788524 3504.895391 0.788895391 -0.342094086 0.0015218210.016060917

Pitpnm1 1577.021128 1385.590981 1768.451275 1.276315521 0.351985025 0.0015297630.016109746

Reck 188.0910201 226.8812605 149.3007797 0.658056903 -0.603715754 0.0015327770.016122244

Repin1 468.5484521 564.780393 372.3165112 0.659223507 -0.601160408 0.0015334380.016122244

Gucy2e 15.68509003 25.38799816 5.982181904 0.235630311 -2.085402958 0.0015417330.016191947 Kank1 533.7570042 617.3447527 450.1692557 0.729202368 -0.455608848 0.0015449360.016216823

Lrrc36 233.8076358 182.2119011 285.4033705 1.566326726 0.647385181 0.0015479770.016233443

Xpot 1396.465245 1570.811732 1222.118757 0.778017335 -0.362125794 0.0015481890.016233443

Hist1h4j 53.06069206 34.39897686 71.72240726 2.085015713 1.060058256 0.0015491550.016234808

Fam111a 204.6057665 122.183541 287.027992 2.34915431 1.232141483 0.00156051 0.016308733

Lmx1b 24.42978167 36.79465652 12.06490682 0.327898341 -1.608679494 0.0015612420.016308733

Pcgf3 666.0698094 758.535486 573.6041327 0.75619947 -0.403161256 0.0015987040.016646392 Pofut2 2061.174715 2316.060854 1806.288575 0.779896854 -0.358644763 0.001626 0.01688016

Slc6a17 1291.011431 1535.082158 1046.940705 0.682009559 -0.552136135 0.0016370070.01696344 Tle3 1709.934873 2018.468152 1401.401595 0.694289674 -0.526390381 0.0016731640.017282839

Irf2bp2 2356.611539 2765.525417 1947.697661 0.704277621 -0.505783855 0.0016842290.017369448

Dnajc27 376.2160528 439.8468784 312.5852271 0.710668286 -0.492751776 0.0016858170.017371118

Iapp 282059.9174 253214.0903 310905.7444 1.227837456 0.296119586 0.00169865 0.017481073

Hpcal4 53.32626035 72.76735264 33.88516805 0.465664434 -1.102637398 0.0017022740.017509105

Rab15 79.85636013 105.9244306 53.78828964 0.507798714 -0.977671354 0.0017321690.017778966

Tmem62 517.0391055 436.396129 597.682082 1.369586122 0.453739988 0.00174614 0.01791291 Gsto1 81.33864562 105.8372455 56.8400457 0.537051445 -0.896867801 0.0017548640.017992913

Klc3 130.0526723 161.0983063 99.00703843 0.614575291 -0.702338331 0.0017713430.018126419

Jup 1583.939483 1846.600284 1321.278682 0.715519592 -0.482936824 0.0017759670.018151836

Nphp4 262.7755978 217.1699563 308.3812393 1.419999546 0.505890468 0.0017889180.01821716

Rem2 55.22569789 73.76371953 36.68767625 0.497367493 -1.007615876 0.0018002160.018322615

Eno3 444.5334207 516.6534377 372.4134036 0.720818592 -0.472291871 0.0018062740.018365044

Fkbp9 4205.603778 4740.516827 3670.69073 0.774322898 -0.368992788 0.0018132740.018416949 Atxn7 1006.440657 875.6351405 1137.246173 1.298767169 0.377142821 0.0018147760.018422583

Tmeﬀ1 78.6816889 102.2143792 55.14899863 0.53954247 -0.890191569 0.0018304040.018542495

Kcnip4 102.6245632 129.3473713 75.90175504 0.586805547 -0.769045585 0.0018350290.018579664

2610524H06Rik 196.080538 157.0988048 235.0622712 1.496270271 0.581370792 0.0018553170.018755781

Spag1 117.3145508 147.0179347 87.61116688 0.595921627 -0.746805488 0.0018658770.018823375

Wdr6 4620.28207 3938.527271 5302.03687 1.346197831 0.428890438 0.0018964750.019102322

Lsm4 377.3755803 314.0511457 440.700015 1.403274661 0.488797413 0.0018983810.019111615 Slc22a23 1557.445607 1914.249012 1200.642203 0.627213176 -0.672972228 0.0019257250.019346817

Ace 1299.847228 1472.722977 1126.97148 0.765229781 -0.386035075 0.0019318960.019398794

Bcl2l14 39.40217674 23.87907932 54.92527416 2.300142037 1.201722952 0.0019468210.019536085

Etnk1 6655.600646 5913.979576 7397.221716 1.250802716 0.322854257 0.0019684760.019664527

Cacna2d1 2448.613839 2720.561007 2176.66667 0.800080081 -0.321783687 0.0019735720.019695193

Dse 291.4506318 238.7697832 344.1314803 1.441268973 0.5273396 0.0019999 0.019927249 Pawr 442.9207599 510.4492986 375.3922213 0.735415295 -0.443368914 0.0020047860.019935061

Kif1b 5409.259285 4579.231785 6239.286785 1.36251823 0.446275532 0.0020174660.020045476

B3galt2 166.9952848 205.5672782 128.4232913 0.62472633 -0.67870376 0.0020284640.020129317

Syn2 682.4059507 796.2942263 568.5176751 0.713954285 -0.486096394 0.0020383380.020216982

Pgk1 202.1270497 161.2136342 243.0404652 1.507567684 0.592222775 0.0020665390.020423751

Cenpa 40.55354579 22.8475844 58.25950718 2.549919771 1.350451856 0.0020884780.020598683

Nup210 1141.128705 1299.707823 982.5495865 0.755977281 -0.403585216 0.0020979330.020650038 Kpnb1 3782.297383 3355.308031 4209.286735 1.254515739 0.327130571 0.0021323150.020924889

Nova1 298.9726801 351.0703151 246.8750452 0.703206835 -0.507979001 0.0021445020.021023261

Rbbp9 349.6869848 292.075207 407.2987626 1.394499611 0.479747532 0.0021510810.021077128

Nipal1 1629.549014 2002.237366 1256.860661 0.627728102 -0.671788299 0.0021548860.021103775

Dopey2 949.2160139 1073.348259 825.0837685 0.768700896 -0.379505745 0.0021783470.02131206

Anapc13 524.3330896 447.5639012 601.102278 1.343053531 0.425516809 0.0021834640.021351383

Klf15 202.5814433 297.070727 108.0921597 0.363860017 -1.458544567 0.0022115190.021593131 Slc35f5 1738.707724 1524.999284 1952.416164 1.280273495 0.356452035 0.0022349240.021788826

Slc17a9 576.218172 482.8808752 669.5554688 1.386585187 0.471536254 0.00223694 0.021792936 Edem3 2462.132007 2115.776935 2808.487078 1.327402256 0.408605632 0.0022723170.02206146

Tmem50b 1181.769077 1337.909344 1025.628811 0.766590663 -0.383471668 0.00227244 0.02206146

Ptprk 483.4178389 556.9232152 409.9124625 0.736030482 -0.44216258 0.0022731020.02206146

Pdx1 2551.052764 1743.09862 3359.006908 1.92703205 0.946380567 0.0023351440.022595914

Lamp2 3699.935403 4101.921186 3297.94962 0.804001216 -0.314730412 0.0023628510.022784633

Atp5o 771.4061157 670.5330184 872.2792131 1.300874363 0.379481635 0.0023695 0.02283742

Ndst4 271.3313363 327.1075581 215.5551145 0.658973201 -0.6017083 0.0023760520.022877885 Wiz 1125.121321 1265.863985 984.3786582 0.77763383 -0.362837113 0.0023845420.022928331

Hsbp1 2454.501368 1935.593068 2973.409669 1.536174994 0.61934257 0.00238483 0.022928331

Pnpo 717.3160474 606.2827035 828.3493913 1.366275809 0.450248749 0.00238849 0.022952176

Por 4621.09631 3880.253134 5361.939486 1.381853013 0.466604166 0.0023899310.022954677

Elk3 1001.500316 1151.666667 851.3339647 0.739219072 -0.435926116 0.0024643060.02351797

Ezh1 1476.90077 1302.599858 1651.201681 1.267620038 0.34212237 0.00246961 0.023557027

Il6ra 2312.998778 2788.539742 1837.457814 0.658931909 -0.601798704 0.0024735990.023583505 Glrb 773.5922123 911.0510004 636.1334242 0.698241288 -0.518202426 0.0024903460.023672792

Cryba2 218.3781742 260.7023617 176.0539867 0.675306451 -0.566385755 0.0024945870.023679084

Atrx 3426.836868 3022.206173 3831.467563 1.267771735 0.342295008 0.0025083080.02377723

Eya1 252.5547755 297.1264553 207.9830957 0.699981749 -0.514610789 0.0025220720.023852114

Tcirg1 332.2874942 387.7308118 276.8441765 0.714011289 -0.485981211 0.0025226310.023852114

Anxa6 2546.021135 2842.624978 2249.417293 0.791316938 -0.337672457 0.0025501140.024076841

Efr3b 345.9398466 403.4245805 288.4551128 0.715016205 -0.483952155 0.0025630650.024161635 Acadm 630.5278982 543.3014267 717.7543697 1.321097892 0.401737373 0.0025639570.024161635

Foxp4 1483.061219 1659.910354 1306.212084 0.786917246 -0.345716168 0.0025640660.024161635

Fmn2 2415.190884 2702.532704 2127.849063 0.787353677 -0.344916258 0.0025667930.024175606

Agl 1021.98837 1175.135093 868.8416456 0.739354692 -0.435661457 0.0025771970.024261848

Elp4 433.4338774 364.8983516 501.9694031 1.37564174 0.460104796 0.0025879240.024351034

Rnf13 1091.419414 953.7369462 1229.101882 1.288722102 0.365941197 0.00260426 0.02448105 Lnpep 1178.906894 952.444679 1405.36911 1.475538833 0.56124189 0.0026082920.024507102

Mcm5 170.0798549 102.0378127 238.1218971 2.333663285 1.222596415 0.0026197560.024595819

Ushbp1 285.206223 337.2079086 233.2045374 0.691574935 -0.532042514 0.00262153 0.024595819

Bcat2 622.4589713 531.5691913 713.3487513 1.341967825 0.424350082 0.0026583340.024905066

Pank3 2903.056822 2493.475313 3312.638332 1.328522611 0.409822782 0.0026877230.025144046

Cyp2d22 275.2286512 322.6475048 227.8097975 0.70606403 -0.502129073 0.0027337110.025537402

Pgr 24.62673903 13.01177981 36.24169825 2.785299073 1.477832246 0.0027441160.025585428 Cep57 614.2666596 525.217086 703.3162332 1.339096256 0.421259667 0.0027510970.02563822

Gm15910 12.97507089 21.34479946 4.605342323 0.215759456 -2.212504304 0.0027599280.025695885

Myh10 862.4412734 978.0253988 746.857148 0.763637784 -0.389039608 0.0027831390.025856889

B4galt2 147.025447 179.7074576 114.3434364 0.636275411 -0.652276726 0.0027838720.025856889

Zfp961 308.7604383 255.3136643 362.2072123 1.41867539 0.504544521 0.0027866540.025870371

Fmn1 71.32386448 92.35702302 50.29070595 0.544524978 -0.876929866 0.0027937270.02592365

1500009L16Rik 129.273897 164.5640341 93.98375995 0.571107536 -0.808165674 0.0028177280.026110161 Utp14b 62.39927332 42.03190995 82.76663669 1.969138133 0.977564318 0.0028191610.026110161

Sec16b 1123.35083 1338.868922 907.8327378 0.67805946 -0.560516305 0.0028191990.026110161 Farp1 730.7680075 828.508697 633.027318 0.764056334 -0.388249082 0.0028218320.026122102

Dcaf11 2245.431274 1996.799838 2494.062711 1.249029904 0.320808018 0.0028282690.026169229

Iars 1450.003207 1687.154968 1212.851445 0.718873765 -0.47618964 0.0028313140.026171589

1700086L19Rik1807.666208 2124.247799 1491.084616 0.701935347 -0.510589941 0.0028325630.026171589

Pip4k2a 460.2334755 529.4282729 391.0386781 0.738605583 -0.437123927 0.0028439720.026252048

Cast 540.9147991 460.2433578 621.5862404 1.350559937 0.433557667 0.0028927530.026601282

Creb3l1 808.6765156 961.8524816 655.5005497 0.681498008 -0.553218656 0.0029115690.026761656 Asph 866.4632013 754.7489423 978.1774603 1.29603025 0.374099392 0.0029192940.026819975

Igf1r 1864.002398 1634.391543 2093.613252 1.28097411 0.357241317 0.0029329970.026920425

Scly 1377.03847 1539.465896 1214.611045 0.788982106 -0.341935514 0.0029501590.027065164

Phtf2 214.9522607 173.9111259 255.9933956 1.471978255 0.557756359 0.0029587150.027118067

Znrf1 875.9774998 990.3750674 761.5799321 0.768981326 -0.378979532 0.0029632370.027146714

Inha 850.2575654 964.7746945 735.7404362 0.762603373 -0.390995183 0.0029699590.027195478

Fam20c 2878.672066 2491.518046 3265.826085 1.310777616 0.390422942 0.0029797540.027272323 Man1c1 967.3418833 1087.903501 846.7802656 0.778359721 -0.36149104 0.0029936410.027371036

Rrm2 139.8841498 96.96727509 182.8010245 1.885182649 0.914704308 0.0030002840.02738287

Iah1 245.7515005 201.862225 289.6407759 1.434843869 0.52089376 0.0030514980.027785066

Crybg3 586.9280117 671.7490367 502.1069866 0.747462161 -0.419927548 0.0030606160.027848978

Fam120c 1696.929225 1503.132255 1890.726195 1.25785751 0.330968503 0.0030779080.027973137

Stat4 60.10069564 33.46523224 86.73615903 2.591828988 1.373970531 0.00308566 0.028030477

Ints3 2643.713947 2354.904447 2932.523447 1.245283413 0.316474121 0.0031146290.028240853 Ptk2 739.0456919 837.3515508 640.7398329 0.765198121 -0.386094765 0.0031251470.028323011

Pacsin1 414.5631695 481.6158518 347.5104872 0.721551182 -0.470826361 0.0031512950.02853338

Map4k4 1487.36504 1659.553617 1315.176463 0.792488082 -0.335538856 0.0031584670.028570151

Kcnc3 1101.768073 1237.288768 966.2473781 0.780939263 -0.356717747 0.0031597650.028570151

Fmo1 1603.297818 605.7442118 2600.851423 4.293646349 2.102203367 0.0031729450.02867258

Slc25a32 415.702254 481.656565 349.7479431 0.726135526 -0.461689257 0.0031740430.02867258 Mat1a 1514.945676 1707.273758 1322.617594 0.774695674 -0.368298412 0.0031792380.028702326

Gcnt4 128.646416 156.9975858 100.2952462 0.638833048 -0.646489147 0.0031802890.028702326

Ppp1r17 152.647286 247.8865509 57.40802111 0.231589898 -2.110355769 0.0031901880.028778313

Magt1 4932.494125 4349.590757 5515.397493 1.268026764 0.342585197 0.0031946550.028798204

Gm8234 43.44258707 58.75461066 28.13056348 0.478780527 -1.062563617 0.0031959250.028798204

Il6st 3104.718201 2414.741726 3794.694676 1.571470206 0.652114919 0.0032074410.028880339

Atg16l2 698.6641606 798.221848 599.1064732 0.750551334 -0.413977346 0.0032266820.029030377 Gnb5 395.4612602 457.1163715 333.8061489 0.730243259 -0.453550959 0.0032270910.029030377

Wdr90 1324.609912 1171.719889 1477.499934 1.260966848 0.334530346 0.0032445020.029173507

Arhgef17 3404.94513 3785.144603 3024.745657 0.79910967 -0.323534581 0.0032492030.029202272

Prdx4 391.8329535 452.2186563 331.4472506 0.732935818 -0.448241226 0.0032768310.029436966

Tmem159 262.7503068 307.0292021 218.4714114 0.711565577 -0.490931375 0.0032844280.029491589

Cdk14 721.4573016 622.3611574 820.5534458 1.318452214 0.398845283 0.0032892110.029516662

Rwdd4a 1017.729146 895.7939128 1139.664379 1.272239476 0.347370258 0.0032902580.029516662 Acta1 12.91546225 21.17438505 4.656539456 0.219913799 -2.184989963 0.0033198930.029741342

Fam135b 65.18673744 94.16550876 36.20796612 0.384514103 -1.378891582 0.0033351790.029864524 Myh9 4171.369468 3713.901903 4628.837032 1.246354145 0.317714061 0.0033607340.030045167

Rbp4 3684.492703 3059.482564 4309.502841 1.408572447 0.494233768 0.0033971370.030349425

6-Mar 3699.757468 3272.615677 4126.89926 1.261039996 0.334614034 0.00340097 0.030369706

Foxa2 1356.804234 1511.50554 1202.102927 0.795301701 -0.330425838 0.0034165140.030480512

Pgbd5 390.7547894 450.9689301 330.5406488 0.732956589 -0.448200341 0.0034674180.030892123

Mtus1 2302.390233 2036.063951 2568.716515 1.261608956 0.335264807 0.0034839680.030986926

Heatr3 508.1183993 435.4869563 580.7498424 1.333564264 0.41528735 0.0034865730.030986926 Txndc11 1271.666411 1020.035689 1523.297132 1.493376308 0.578577749 0.0034914490.03099417

Srsf6 4460.532002 4918.325585 4002.738418 0.813841692 -0.297179905 0.0034916270.03099417

Rﬄ 343.3588833 290.2699897 396.4477769 1.365789751 0.449735413 0.0034962580.031006963

Ddo 294.367735 242.8122492 345.9232208 1.424653089 0.510610657 0.00355397 0.031432748

Dars 883.1407106 772.1252214 994.1561999 1.287558251 0.364637704 0.0035613640.031483816

Fzd5 68.02228714 88.075332 47.96924229 0.54463879 -0.876628357 0.0036124830.031848826

Zdhhc3 1008.384352 1133.047309 883.7213953 0.779951012 -0.358544583 0.0036203810.031890486 Elmo1 480.7571423 370.7985675 590.7157171 1.593090613 0.671828328 0.0037095780.032593599

A230050P20Rik736.3654015 832.8289756 639.9018274 0.768347219 -0.380169677 0.0037779230.033142066

Fitm2 368.2866637 426.1046251 310.4687023 0.728620822 -0.45675987 0.0038168740.033438501

Spon2 382.2174193 491.986179 272.4486597 0.553772995 -0.852633394 0.0038765130.033838978

Shc1 2945.427716 2572.682286 3318.173146 1.289771833 0.367115868 0.0038795650.033850426

Galnt9 283.4081808 206.8818685 359.9344931 1.739806856 0.798927154 0.0038818510.033852586

Slc25a22 732.1243231 831.3104906 632.9381556 0.761373954 -0.393322877 0.0038886870.033875054 1700096K18Rik79.86435823 101.8258883 57.90282815 0.568645451 -0.814398679 0.0038928430.033875054

9430015G10Rik228.2808306 268.9366067 187.6250544 0.69765532 -0.519413653 0.00389943 0.033917193

Kctd12b 2349.869468 1656.096643 3043.642293 1.83784099 0.87801195 0.0039086240.033981955

Tnfrsf1a 958.0321847 842.7228617 1073.341508 1.273658941 0.348979006 0.00394268 0.034247407

Mob1a 421.3895345 356.133565 486.645504 1.366469078 0.450452813 0.0039996950.034618907

Fam160a2 922.4387052 1034.164615 810.7127956 0.783930125 -0.351203029 0.0040320050.034852017 Tbc1d9 827.7262472 928.7113012 726.7411933 0.782526488 -0.353788507 0.0040345170.034858225

Alg12 501.1239717 434.2421169 568.0058265 1.308039466 0.38740607 0.0040418260.034905865

Acp1 220.6745419 263.4523099 177.8967739 0.675252284 -0.566501481 0.0040755120.035181154

Spint1 2830.995107 2518.742632 3143.247583 1.247943138 0.319552199 0.0040804520.035208162

Pfdn2 490.6768665 424.2797337 557.0739994 1.312987529 0.392853214 0.0041015460.035348949

Cebpg 1576.754166 1761.705554 1391.802778 0.790031441 -0.340018025 0.0041034 0.035348949

Cnst 1210.008551 1346.855377 1073.161726 0.796790616 -0.327727438 0.0041439530.035661113 Cpne3 1149.483774 1010.514564 1288.452985 1.275046428 0.35054978 0.0041692780.035832792

Anxa7 2570.751962 2107.345894 3034.15803 1.43980067 0.525869095 0.0041778650.035889389

Mgrn1 2131.706251 1900.087866 2363.324636 1.243797552 0.314751683 0.00418818 0.035962115

Cd55 189.8714009 91.41384885 288.3289529 3.154105823 1.657231064 0.0042125230.036139212

Acbd5 1889.435753 1677.511935 2101.35957 1.252664453 0.325000016 0.0042372460.036287254

Klhdc1 87.2347411 109.4506733 65.01880891 0.594046678 -0.751351797 0.0042437540.036326981

Tmem215 3931.52792 4340.062167 3522.993672 0.811738066 -0.300913825 0.0042459830.036330062 Gatad2a 1134.070066 1001.045804 1267.094329 1.265770581 0.340015943 0.0042874050.036636109

C2cd4a 123.9895865 66.60908888 181.3700841 2.722902942 1.445145558 0.0042915330.036639173 Neat1 14608.02157 9511.173734 19704.86941 2.071760012 1.050856894 0.0043024170.036715974

AI413582 255.6067108 300.0783932 211.1350283 0.70359957 -0.507173495 0.00431022 0.03675784

Dnajc6 1168.552597 1010.966754 1326.138441 1.311752771 0.391495837 0.0043309210.036893073

1700030C10Rik9.562666703 16.71457078 2.410762627 0.144231202 -2.793544798 0.00437073 0.037119697

Atp6v0e 1247.438341 1107.652224 1387.224458 1.252400734 0.324696259 0.0043746930.037137129

Arsa 791.9741285 890.8533446 693.0949124 0.778012359 -0.362135021 0.0044250010.037466033

Isoc2b 264.7450395 222.1157546 307.3743244 1.383847467 0.468684932 0.00443663 0.03754814 Cdc20 69.04802989 29.8568027 108.2392571 3.625279577 1.858092258 0.0044550530.037615954

Arpc5l 1016.595225 902.5050116 1130.685439 1.252830094 0.325190773 0.0045153120.038031915

Kdelr3 106.9908292 132.9485404 81.03311808 0.609507392 -0.714284378 0.0045673720.038381445

Plekhn1 232.4384287 273.0771255 191.7997318 0.702364694 -0.509707768 0.0045851450.038453499

Ppp1r26 629.8233361 713.3921441 546.2545281 0.765714247 -0.385121995 0.0046118780.038610244

Ptprs 562.8266972 637.9554823 487.697912 0.764470132 -0.387467958 0.0046457050.038766004

Lrp10 1820.436981 1617.876156 2022.997805 1.250403374 0.322393577 0.0046998020.039144879 Mthfr 2055.819648 2273.438287 1838.201008 0.80855549 -0.306581308 0.0047018520.039145185

Rnf181 1648.052537 1443.245523 1852.859552 1.283814516 0.360436779 0.00475064 0.039500613

Atrn 1477.017831 1308.070981 1645.964681 1.258314499 0.331492549 0.0047635520.039574122

Fkbp14 377.9465663 322.5326343 433.3604983 1.34361752 0.426122513 0.0047736940.039641439

Arhgap27 224.4221071 264.9475065 183.8967077 0.694087331 -0.526810898 0.0047851230.039685489

Kdm2b 437.1799121 505.8684345 368.4913898 0.728433254 -0.45713131 0.0048008980.039799338

Speg 411.3026742 479.5002633 343.105085 0.71554723 -0.4828811 0.0048228240.039930028 Relt 261.1744424 315.3903192 206.9585655 0.656198218 -0.607796419 0.00483303 0.039997488

Mettl9 1169.947215 1039.051086 1300.843343 1.25195321 0.324180645 0.00487477 0.04029147

Tchp 339.6291022 391.7084955 287.5497088 0.73409107 -0.445969042 0.00490329 0.040509972

Iﬁ27l2a 22.18868476 11.63088688 32.74648264 2.815475982 1.493378844 0.0049147550.040587444

Rab1 5288.890255 4657.488126 5920.292383 1.271134187 0.346116336 0.0049707740.041015212

Asphd2 18.74485003 28.46648931 9.023210761 0.316976592 -1.657551791 0.0049755340.041037077 Cldn6 184.0112875 220.1953389 147.8272361 0.671345892 -0.57487183 0.0050014830.041163773

Dyrk2 426.3609931 535.6963888 317.0255975 0.591800886 -0.756816239 0.0050140690.041249897

Mrpl49 464.6885593 399.8085899 529.5685287 1.324555155 0.405507919 0.0050486060.041481363

Tmem55b 906.6748333 1020.658464 792.6912026 0.776646871 -0.364669317 0.0050548920.041515465

D5Ertd579e 2288.292324 2608.005375 1968.579273 0.754821785 -0.405792033 0.0050660570.041587112

Hnmt 116.6642213 89.78478598 143.5436566 1.598752562 0.676946671 0.0050678940.041587112

Slc2a13 797.3993553 522.1459552 1072.652755 2.054315933 1.038658071 0.0050910940.041738979 Lingo3 35.73344648 48.82503875 22.64185421 0.463734485 -1.10862908 0.0050928420.041738979

Rps11 2201.114638 1969.619771 2432.609504 1.235065539 0.304587601 0.0051002590.041782146

Lama4 465.1783917 531.4915199 398.8652636 0.750464022 -0.414145186 0.0051451580.042079035

Sdhaf2 611.2417146 533.720272 688.7631573 1.290494653 0.367924164 0.0051572480.042160177

Rps6ka2 2177.790555 2534.536067 1821.045043 0.718492456 -0.476955087 0.0051868760.042348954

Ngef 63.79105382 44.87976338 82.70234427 1.842753572 0.881863155 0.00519103 0.042349272

Aifm1 477.1544827 411.6425748 542.6663906 1.318295103 0.398673357 0.0051912710.042349272 Pigu 501.7652021 432.7297475 570.8006566 1.319069604 0.399520694 0.0052077850.042466163

Gpx2 47.41193193 63.82731732 30.99654654 0.485631354 -1.042066525 0.0052472430.042752055 Prpf40a 1238.986266 1095.014762 1382.95777 1.262958106 0.336806784 0.0052563420.042808247

Nynrin 724.1539043 811.7698115 636.537997 0.784136079 -0.350824053 0.0052643920.042855854

Atp1a3 86.72483476 109.1351128 64.31455674 0.589311314 -0.76289813 0.0052878270.042974645

Pdgfc 45.57499067 66.39041831 24.75956303 0.372938801 -1.422989189 0.00535548 0.043451804

Trip6 106.5199353 132.5490541 80.49081641 0.607253043 -0.719630282 0.0053746950.043589513

Ankrd23 133.9362743 162.6177994 105.2547491 0.647252327 -0.627599847 0.0054295130.043997387

Tmed7 3567.706335 3225.593964 3909.818707 1.212123643 0.277536869 0.0054514020.044101226 Phgdh 114.7500879 166.5366344 62.96354127 0.37807622 -1.403250984 0.0054863760.044328826

Mapk8ip3 2883.190905 2587.110282 3179.271528 1.228889062 0.297354682 0.0055053120.044430503

Bfsp2 4.932225165 0.536941718 9.327508613 17.37154761 4.118654383 0.00554992 0.044712163

Abcb10 1038.079046 1156.644939 919.5131537 0.794983078 -0.331003943 0.00555775 0.044756693

Zcchc18 2152.930305 2399.503507 1906.357103 0.794479815 -0.331917528 0.0055650190.044787962

Plcl1 114.4413852 88.80710516 140.0756653 1.577302459 0.657459334 0.0055805040.0448766

Gars 3125.65049 3449.09876 2802.20222 0.812444762 -0.299658368 0.0055935140.044933022 Filip1 721.4357478 807.2362338 635.6352619 0.787421619 -0.344791773 0.0056362360.045230777

Atox1 278.2672271 233.9157653 322.6186888 1.379208829 0.463840915 0.00567085 0.045420998

Crybb1 9.423100819 18.41702143 0.429180204 0.023303454 -5.423312412 0.0056729520.045420998

Lig1 270.718364 207.5280864 333.9086416 1.608980487 0.68614683 0.0056768830.045433761

Nav3 72.81676076 92.33618606 53.29733547 0.577209627 -0.792832734 0.00571924 0.04575392

Ufm1 2736.508171 3037.496043 2435.5203 0.801818427 -0.318652521 0.0057533460.045988915

Caskin2 904.9505668 1009.822539 800.0785943 0.792296233 -0.335888151 0.0057952340.046266676 Pard3 1702.239084 1509.79065 1894.687518 1.254933932 0.327611414 0.0058130190.046351556

Ankrd16 367.0785871 420.8730844 313.2840897 0.744367129 -0.425913746 0.0058243950.046404196

Fam159b 559.0773047 423.8396069 694.3150026 1.638155074 0.712071934 0.0058660010.046648752

Fhad1 182.9270367 217.1335468 148.7205265 0.684926529 -0.545978854 0.0058677840.046648752

Uhrf1bp1 709.9722385 809.8799447 610.0645324 0.753277737 -0.408746203 0.0059051510.046874696

Pitpna 1489.39882 1327.798444 1650.999195 1.243411003 0.31430325 0.0059160120.046906688 Mpp6 313.226044 266.2725802 360.1795078 1.352672166 0.43581223 0.0059198630.046914852

Trip12 4487.687375 4023.749181 4951.62557 1.230599957 0.299361847 0.0059418040.047031219

Spry2 163.5083653 195.5274039 131.4893267 0.672485412 -0.572425124 0.0060274440.047548842

Casc4 2492.623998 2234.274459 2750.973537 1.231260343 0.300135844 0.0060292130.047548842

Ano6 2065.25436 2280.632529 1849.87619 0.81112418 -0.302005292 0.0060712230.047841338

Cbln1 6.091403303 1.278556435 10.90425017 8.528563837 3.09230282 0.0060887730.047960187

Nﬁa 317.8214352 267.5310143 368.1118561 1.375959558 0.460438067 0.0061635520.048451053 Ddx5 18157.56522 19898.70496 16416.42547 0.824999692 -0.277534513 0.0062551540.049012576

Tmem147 650.9480636 734.7877827 567.1083444 0.771798821 -0.373703255 0.00629439 0.049242151

Cep192 333.217044 280.8543625 385.5797254 1.372881382 0.457206981 0.0062945860.049242151

Tacc1 1732.264755 1912.814564 1551.714946 0.811220793 -0.301833464 0.0062988190.049255447

Anpep 1588.382318 1905.046344 1271.718291 0.667552417 -0.583046972 0.0063210770.049409628

Prps1 1771.596364 1969.083671 1574.109057 0.79941197 -0.32298892 0.0063539130.049566643

Anxa11 279.2426466 322.3711829 236.1141103 0.732429332 -0.449238525 0.0063949940.049787219