BANFF-CST Joint Scientific Meeting October 5 – 10, 2015 Vancouver, British Columbia

www.banfffoundation.org www.cst-transplant.ca

MONDAY, OCTOBER 5, 2015

BANFF PRE-MEETING: PRECISION DIAGNOSTICS IN TRANSPLANTATION - MOLECULAR PATHOLOGY (MORNING SESSION) GRAND BALLROOM AB + PASSAGE (MODERATORS: ALEXANDRE LOUPY, MICHAEL ME NGEL) Start End Description Alexandre Loupy, Michael Mengel 08:00 08:15 Introduction and Objective: Consensus in Molecular Transplant Diagnostics Philip Halloran 08:15 08:45 Molecular Assessment and Landscape of ABMR in Kidney Transplants Enver Akalin 08:45 09:15 Clinical and Molecular Significance of Microvascular Inflammation in Kidney Allografts Jeff Reeve 09:15 09:45 Molecular Assessment of TCMR, Mixed Rejection & Borderline Lesions Minnie Sarwal 09:45 10:15 A Cross Organ Common Immune Module for Reejection Coffee Break Michael Mengel 10:30 11:00 Molecular Assessment of ABMR in Heart Transplants Daniel Salomon 11:00 11:30 What’s New in Non-Invasive Biomarkers: Blood Thangamani Muthukumar 11:30 12:00 What’s New in Non-Invasive Biomarkers: Urine LUNCH SYMPOSIUM: ANTI-GRAFT ANTIBODIES IN TRANSPLANTATION: IMPROVING THE GOLD STANDARD, IMPLEMENTING COMPLEMENTARY APPROACHES AND MOVING BEYOND HLA (LUNCH PROVIDED WITH SUPPORT FROM ONE LAMBDA. A THERMOFISHER SCIENTIFIC BRAND.) GRAND BALLROOM AB + PASSAGE (MODERATORS: CARMEN LEFAUCHER, ANAT TAMBUR) Start End Description Anat Tambur 12:00 12:30 What’s Hot - What’s New in HLA Science: Take Home Messages from the 2015 ASHI Adriana Zeevi 12:30 01:00 An Overview of Laboratory Testing Methods in SOT: Value and Limitations Peter Nickerson 01:00 01:30 The Future of HLA: Eplet Mismatch to Improve Transplant Candidates Risk Assessment BANFF PRE-MEETING: PRECISION DIAGNOSTICS IN TRANSPLANTATION - MOLECULAR PATHOLOGY (AFTERNOON SESSION) GRAND BALLROOM AB + PASSAGE (MODERATORS: ALEXANDRE LOUPY, MICHAEL ME NGEL) Start End Description Osmar Zaiane 01:30 02:00 Insights of Big Data Analyses in the 21st Century of Biomedical Research Kim Solez 02:00 02:30 Bridge between Transplantation and Regenerative Medicine Kim Solez for Doris Taylor 02:30 03:00 Building New Hearts. Regenerative Medicine Becomes a Reality Coffee Break Paul Keown 03:30 04:00 Next Generation Sequencing: Applications in Transplant Diagnostics Parmjeet Randhawa An example for Clinical Application - Next Generation Sequencing in Biopsies with 04:00 04:15 Polyomavirus BK Nephropathy: Patient - specific TCR b utilization patterns and presence of unique T-cell clonotypes TUESDAY, OCTOBER 6, 2015

CST BOARD MEETING PORT HARDY Start End Description 07:00 05:00 Closed Meeting

BANFF: SUMMARY OF PREMEETING, BANFF WORKING GROUPS RESULTS AND DIRECTIONS REGARDING BANFF CLASSIFICATION AMENDMENTS (CO-SPONSORED BY RENAL PATHOLOGY SOCIETY) GRAND BALLROOM AB + PASSAGE (MODERATORS: LORRAINE RACUSEN, KIM SOLEZ) Start End Description Kim Solez, Lorraine Racusen 08:00 08:15 Banff Meeting Intro Kim Solez, Michael Mengel 08:15 08:30 Annual Report from the Banff Foundation Michael Mengel 08:30 08:45 Summary of the Pre-Meeting Parmjeet Randhawa 08:45 09:00 Borderline/TCMR Working Group Update Lynn Cornell 09:00 09:15 Highly Sensitized Working Group Update Banu Sis 09:15 09:30 Molecular Group Update Volker Nickeleit 09:30 09:45 BKv Group Update Helen Liapis 09:45 10:00 Implantation Biopsy Working Group Final Report Coffee Break Mark Haas 10:30 10:45 The New Diagnostic Criteria for ABMR (Banff 2013): Remarks, Difficulties, Amendments? Banu Sis 10:45 11:00 What Criteria Should Apply to Isolated V Lesions and How To Update the Classification? Volker Nickeleit 11:00 11:15 Prospects for Modifying/Improving the Banff Criteria for Borderline and TCMR M. Haas, B Sis, B Colvin 11:15 11:45 Group Discussion LUNCH SYMPOSIUM: MTORI IN SOLID : NEW UNDERSTANDINGS, NEW DIRECTIONS AND ADVANCES (LUNCH PROVIDED WITH SUPPORT FROM NOVARTIS) GRAND BALLROOM AB + PASSAGE(MODERATORS: ALEXANDRE LOUPY, CHRISTOPHE LEGENDRE) Start End Description Federico Oppenheimer 12:00 12:20 Clinical Relevance of New Strategies Using Combined mTORi and Reduced CNI Regimens in Kidney Transplants Guillaume Canaud 12:20 12:40 mTORi for Preventing Antiphospholipid Syndrome Recurrence Post Luciano Potena 12:40 01:00 mTORi Based Strategies for Preventing Chronic Heart Allograft Vasculopathy BANFF KIDNEY CONCURRENT I: ANTIBODIES AND INJURY TO GRAFT ENDOTHELIUM AND EPITHELIUM GRAND BALLROOM AB + PASSAGE (MODERATORS: LYNN CORNELL, CANDICE ROUFOSSE) Start End Description Christopher Bellamy 01:00 01:30 Multiplex in situ phenotyping of macrophages in allograft biopsies Roger Wiggins 01:30 02:00 Podocyte Injury After Transplantation: Novel Insights

1 Candice Roufosse 02:00 02:30 Significance of Double Contours and Peritubular capillary basement membrane multilayering in renal allograft biopsies Robert Colvin 02:30 03:00 The Pathology of Tolerance and ABMR: From Animal Model to Human Biopsies Coffee Break Elaine Reed 03:30 04:00 Anti-HLA Antibody Binding Trigger Endothelial Cell Signaling: Molecular Pathways and Functional Consequences Annette Jackson 04:00 04:30 Endothelial Cell Rreactive Antibodies: Novel Antigenic Targets Associated With Microvascular Injury in Kidney Transplantation Carmen Lefaucheur 04:30 05:00 Endothelium and Transplant Arteriosclerosis from Heart to Kidney: Epidemiologic Demonstration BANFF LIVER CONCURRENT I GRAND BALLROOM D (MODERATORS: JACQUELINE O’LEARY, MAX SMITH) Start End Description Jake Demetris 01:00 01:30 Welcome & Session Goals Luis G. Hidalgo 01:30 02:00 Eosinophils and NK cells in ADCC and Liver Injury Christopher Bellamy 02:00 02:30 Macrophages in Liver Allografts Delsey Neil 02:30 03:00 C4d TMA Concordance Study Results Coffee Break Geoff McCaughan 03:30 04:00 Liver Allograft Pathology After Effective Anti-HCV Therapies - Changes and Challenges Arnaud Del Bello 04:00 04:30 De Novo DSA: Clinical and Histopathological Manifestations BANFF LUNG CONCURRENT: CHRONIC LUNG ALLOGRAFT DYSFUNCTION GULF ISLANDS BCD (MODERATORS: CAROL FARVER, DEAN W. WALLACE) Start End Description Jamie Todd 01:00 01:30 Clinical Features of Chronic Lung Allograft Dysfunction (CLAD) David Hwang 01:30 02:00 Pathophysiology of CLAD/RAS (Restrictive Allograft Syndrome) Elizabeth Pavlisko 02:00 02:30 Pathophysiology of CLAD/BOS (Bronchiolitis Obliterans Syndrome) Rajan Saggar 02:30 03:00 Pathophysiology of CLAD/Chronic Vascular Changes Coffee Break Carol Farver 03:30 04:00 The Pathology of Antibody-Mediated Rejection in Pediatric Nancy Reinsmoen 04:00 04:30 HLA and Non-HLA Donor Specific Antibodies and Clinical Outcomes in Lung TX 04:30 05:00 Group Discussion

CNTRP (POSITIVE STUDY (PROJECT 6) MEETING) GRANVILLE Start End Description 12:30 05:00 External Meeting

2 CST RESEARCH FITS: PLANNING A CAREER IN ACADEMIC TRANSPLANT PROGRAMS ORCA (MODERATOR: JEFFREY SCHIFF) Start End Description Jeffrey Schiff 01:00 01:10 Opening Remarks Alp Sener 01:10 01:40 Starting a Basic Science Research Program Christine Ribic 01:40 02:10 Starting a Clinical Science Research Program Jeffrey Schiff 02:10 02:40 Creating a Teaching Dossier A. Sener, C. Ribic, J, Schiff 02:40 03:00 Panel Discussion Coffee Break 03:30 03:55 Breakout Session #1 with Transplant Program Directors 03:55 04:20 Breakout Session #2 with Transplant Program Directors 04:20 04:50 Panel Session with Program Directors Jeffrey Schiff 04:50 05:00 Closing Remarks PROBE MEETING GALIANO Start End Description 04:00 05:30 External Meeting SPONSOR COCKTAIL RECEPTION CONSTELLATION SUITE Start End Description 05:00 06:00 By Invitation only CANADIAN PEDIATRIC GROUP BUSINESS MEETING & SESSION FINBACK (MODERATORS: AVIVA GOLDBERG, SEEMA MITAL) Start End Description Aviva Goldberg 06:00 06:30 Welcome and Introductions Brendan Keating 06:30 07:00 Discovering Genomic Underpinnings of Rejection and Complications in Transplantation Chia Wei Teoh 07:00 07:15 Trainee Abstract Award Presentation 07:15 07:30 Updates on Research Initiatives, New Collaborative Research 07:30 08:00 Business Meeting (Members only) EXHIBIT HALL GRAND BALLROOM CD Start End Description 06:00 11:45 Exhibitor Setup

3 WEDNESDAY, OCTOBER 7, 2015

JOINT AST-BANFF-CST SYMPOSIUM GRAND BALLROOM AB + PASSAGE (MODERATORS: JIM ALLAN, STEVEN PARASKEVAS, KIM SOLEZ) Start End Description Rob Fairchild 07:00 07:20 Tests of T Cell Reactivity Kathryn Tinckam 07:20 07:40 Failure to Adopt: Screening for Donor Specific Antibodies Robert Colvin 07:40 08:00 Mixing mRNA and microscopes: The Biopsy with and without molecular diagnostics Roslyn Mannon 08:00 08:20 Is the Problem Failure to Demonstrate the Added Value of the Test(s) or a Lack of Therapeutics? POSTER SETUP GRAND BALLROOM CD Start End Description 07:00 09:30 Wednesday Poster Boards – Poster Setup JOINT PLENARY SESSION #1: FUTURE DIRECTIONS OF TRANSPLANTATION: EXPANDING THE DONOR POOL AND IMPLEMENTING NEW TECHNOLOGIES GRAND BALLROOM AB + PASSAGE (MODERATORS: JOSEPH KIM, GREG KNOLL) Start End Description Steven Paraskevas, Kim Solez 08:30 08:40 Presidents’ Opening Remarks John Gill 08:40 09:05 Extending the donor pool: New registries, allocation, and policies: North American perspectives Christian Jacquelinet 09:05 09:25 Extending the donor pool: New registries, allocation, and policies: European perspectives Coffee Break among Posters Darren Freed 10:00 10:25 Extending the Donor Pool II: Preservation Across Different Organs (Pulsatile Perfusion Devices) Julie Ho 10:25 10:50 Implementing Omics into Daily Practice: Taking the Road and the Lessons from Nephrology PRESIDENTS’ MEETING GULF ISLANDS BCD Start End Description 09:00 10:30 External Meeting LEADING CLINICAL PRACTICES COMMITTEE MEETING GULF ISLANDS BCD Start End Description 11:00 12:00 External Meeting JOINT ORAL ABSTRACT PRESENTATIONS - SESSION I GRAND BALLROOM AB + PASSAGE (MODERATORS: PROSANTO CHAUDHURY, ALEXANDRE LOUPY) Start End Description Marion Rabant 11:00 11:10 Heterogeneity of isolated v lesions in kidney transplantation Darren Freed 11:10 11:20 Ex vivo perfusion in a loaded state improves the preservation of donor heart function Sacha De Serres 11:20 11:30 Critical Apparaisal of the New Banff Criteria for Chronic Antibody-Mediated Rejection in the Real Life Setting

2 Qianni Hu 11:30 11:40 Mitochondrial Damage-Associated Molecular Patterns (MTDs) released from hepatic reperfusion induce inflammatory response Alexandre HERTIG 11:40 11:50 Markers of Endothlial-to-mesenchymal transition: evidence for Antibody-Endothelium interaction during antibody-mediated rejection Anand Ghanekar 11:50 12:00 Differentiation of Functional Cholangiocytes from Human Pluripotent Stem Cells for the Modeling of Biliary Disease LUNCH SYMPOSIUM: COMPLEMENT-MEDIATED DISEASES IN RENAL TRANSPLANTS AND THEIR LINK TO ABMR (LUNCH PROVIDED WITH SUPPORT FROM ALEXION PHARMACEUTICALS) GRAND BALLROOM AB + PASSAGE (MODERATORS: KATHRYN TINCKAM) Start End Description Christophe Legendre 12:00 12:20 Targeting Complement in Recurrent Atypical Haemolytic Uraemic Syndrome John Gill 12:20 12:40 The Role of Complement and Complement Inhibition in Recurring Glomerulonephritis Steven Sacks 12:40 01:00 Targeting Complement for Preventing Delay Graft Function CANADIAN KIDNEY TRANSPLANT WORKING GROUP BUSINESS MEETING GALIANO Start End Description 01:00 05:30 Closed Meeting (Members only) CANADIAN LIVER TRANSPLANT NETWORK (CLTN) BUSINESS MEETING GALIANO Start End Description 01:00 05:30 Closed Meeting (Members only) BANFF LIVER CONCURRENT II FINBACK (MODERATORS: CHRISTOPHER BELLAMY, STEFAN HUBSCHER) Start End Description Stefan Hubscher 01:00 01:30 Pathophysiologic Mechanisms of Liver Allograft Injury/Fibrosis Sandy Feng 01:30 02:00 Long-Term Follow-up and Weaning in Pediatric Recipients: Factors Influencing the Graft Jacqueline O'Leary 02:00 02:30 Chronic Antibody-Mediated Rejection: Perspectives and Issues Coffee Break among Posters 03:30 05:00 Group Discussion BANFF PANCREAS CONCURRENT I: UPDATE ON PANCREAS ALLOGRAFT PATHOLOGY ISSUES / II: ACCURATE DETERMINATION OF THE CAUSE OF GRAFT LOSS IN WHOLE PANCREAS TRANSPLANTS ORCA (MODERATORS: CINTHIA DRACHENBERG, JON ODORIC) Start End Description Danniele Holanda 01:00 01:25 Utility of Duodenal Cuff Biopsies for Diagnosis of Pancreas Rejection Erik Larsson 01:25 01:50 CMV Infection of the Duodenal Cuff in Whole Pancreas Allografts Megan Troxell 01:50 02:15 Pale Acinar Nodules and Other Peculiar Histological Findings in Pancreas Allografts Hanneke de Kort 02:15 02:40 Clinical and Diagnostic Issues Regarding Vascular Lesions in Pancreas Allografts María Toniolo 02:40 03:00 Clinical Impact of Performing Concurrent Pancreas-Kidney Allograft Biopsies Coffee Break among Posters

3 John Papadimitriou 03:30 03:55 Morphological Spectrum of Lesions Associated with Graft Failure in Pancreas Transplants David Klassen 03:55 04:20 Graft Failure in Whole Pancreas and Islet Transplants: UNOS Perspective Rainer Gruessner 04:20 04:45 Clinical Aspects of Pancreas/Islet Failure Steven Paraskevas 04:45 05:10 Clinicopathological Algorithm for the Accurate Etiological Diagnosis of Graft Failure in Pancreas Transplants 05:10 05:30 Closing Comments, Future Plans, Group Discussion BANFF HEART CONCURRENT I & II: IMPROVING HEART DIAGNOSTIC SYSTEM: UNMET NEEDS, CURRENT LIMITATIONS, NEW IMPLEMENTATIONS AND FUTURE DIRECTIONS PAVILLION BALLROOM C (MODERATORS I: GERALD BERRY, LORI WEST; MODERATORS II: REX NEAL SMITH) Start End Description Patrick Bruneval 01:30 01:50 The Pathological Classification of Antibody-Mediated Rejection: Certainties, Uncertainties and Prospects for its Improvement Adriana Zeevi 01:50 02:10 DSA in Thoracic Transplant: Where Do We Stand? Annalisa Angelini 02:10 02:35 Microcirculation Injury in Acute and Chronic Heart Rejection Elaine Reed 02:35 03:00 Endothelial Cell in Cardiac AMR: Interplay Between Antibodies, Complement, and Leukocytes Coffee Break among Posters Dylan Miller 03:30 04:00 Modern Pathology of CAV in the Era of AMR Thomas Thum 04:00 04:30 MicroRNAs and Small Non-Coding RNA’s in : Tissue and Sera Scott Tebbutt 04:30 05:00 Leukocyte Transcripts as Biomarkers in Cardiac Transplantation 05:00 05:30 Group Discussion ALLIED HEALTH GROUP SESSION & BUSINESS MEETING PAVILLION BALLROOM D Start End Description Janet Madill 01:30 01:45 Welcome and Introductions Sean Spina 01:45 02:30 Technology in Clinical Practice. How the Digital Revolution is Affecting Patient Care. Nancy Howes 02:30 03:00 The TONE Program: The Transplant ONline Exercise Program. How Physiotherapists Can Use Technology to Promote Preoperative Exercise Coffee Break among Posters Daniel Buchman 03:30 04:10 The Illusion of Privacy Tania Janaudis-Ferreira 04:10 04:17 Physical Activity Participation in Solid Organ Transplant Recipients: What are the Barriers and Facilitators? Natalia Liapounova 04:18 04:25 Pediatric pre-transplant cognitive function, behavior problems and lung allocation system (LAS) scores. Holly Mansell 04:26 04:33 A qualitative analysis of pre-transplant educational needs from the post-transplant perspective

4 Tania Janaudis-Ferreira 04:34 04:41 Changes in functional outcomes after an inpatient rehabilitation program for solid organ transplant recipients 04:45 05:20 Allied Health Business Meeting (Members only) 05:20 06:30 Networking Session with CANRESTORE CANADIAN DONATION GROUP BUSINESS MEETING PAVILLION BALLROOM AB Start End Description 01:30 03:30 Closed Meeting (Members only) POSTER DISMANTLE GRAND BALLROOM CD Start End Description 07:00 07:30 Wednesday Poster Boards – Poster Dismantle OKTOBERFEST SOCIAL VANCOUVER ART GALLERY ROOFTOP Start End Description 07:30 11:00 Ticketed social event

5 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 9:30AM) GRAND BALLROOM CD Alvita Chan Impact of Social Determinants of Health on Antoine Roux DSA characteristics associated with antibody mediated rejection in Lung Transplantation. Berna Yelken The Effect of C1q Test Done Before Kidney Transplantation on Acute Rejections: Center Experience Chee Loong Saw Pattern of Pre- and Post-Transplant Anti-HLA Antibody Detection in Pediatric Renal Transplant Recipients Isabelle Lapointe Eplet Analysis Supports Easier Identification and Exclusion of Allele Specific HLA Antibodies Joseph Kim Early Hospital Readmissions Following Kidney Transplantation: A Systematic Review Luis G. Hidalgo A CASE OF HEART VALVE REPLACEMENT LEADING TO EXTENSIVE SENSITIZATION - AN EXAMPLE OF THE WORST HLA CLASS II TYPING FOR A TRANSPLANT RECIPIENT Maria Picken Adenovirus Infection in Kidney Transplant Recipients María Toniolo Simultaneous pancreas-kidney transplant: Histologic evaluation Ngan Lam Validation of Kidney Transplantation Using Administrative Data Nicholas Dawson DESIGN AND OPTIMIZATION OF MASS CYTOMETRY TO MEASURE IMMUNE RECONSTITUTION POST- HEMATOPOEITC STEM CELL TRANSPLANT Patrick Luke WARM BLOOD-BASED REPERFUSION WITH CORM-401 REDUCES ISCHEMIA REPERFUSION INJURI (IRI) IN AN EX-VIVO PORCINE MODEL OF THE DONATION AFTER CIRCULATORY DEATH KIDNEY DONOR Renata Ponsirenas Enhancing positive predictive values for antibody mediated rejection through improved antibody characterization RK Sharma Donor Specific Antibodies (DSA) in living related transplantation Sait Sen EVALUATION OF PATIENTS WITH ANTIBODY MEDIATED REJECTION AFTER KIDNEY TRANSPLANTATION Tomokazu Shimizu Subclinical nephrotoxicity in protocol biopsies obtained more than 5 years after renal allograft transplantation Trana Hussaini Investigating the Association between Hypomagnesaemia and Calcineurin Inhibitor Induced Nephrotoxicity in Liver Transplant Recipients: A Case-Control Study Yasemin Ozluk The efficacy of immunoadsorbtion in the treatment of late antibody mediated rejection

6 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 3PM) GRAND BALLROOM CD Andre Teixeira THE ROLE OF POSTREPERFUSION BIOPSIES IN LIVER TRANSPLANTATION; CORRELATION BETWEEN CLINICAL, LABORATORIAL AND HISTOPATHOLOGICAL FINDINGS Bahman Afzali From ultrastructure to molecular testing: Assessment of antibody-mediated tissue injury in human cardiac allograft biopsies Berna Yelken Protocol biopsy is very important for kidney graft survival in desensitize patients Heather Stevenson Isolated obliterative arteriopathy in liver allografts should prompt evaluation for underlying chronic antibody- mediated rejection Johann Moritz Kaths Normothermic Ex Vivo Kidney Perfusion Represents a Novel Preservation Method for Heart Beating Donor Kidney Grafts Marie-Chantal Fortin Donors’ and recipients’ views on altruistic unbalanced paired kidney exchange Maryam Demian Higher Self Efficacy and Simplification of Dosing Regimen are Predictive of Better Medication Adherence in Adult Renal Transplant Recipients Maud Racape A NEW DIAGNOSTIC SCORE FOR MICROVASCULAR INFLAMMATION IN ANTIBODY MEDIATED REJECTION IN HEART TRANSPLANTATION Medhat Askar Comparison Between IgG and IgM De Novo Donor Specific HLA Antibody (dnDSA) Characteristics Among Patients with Symptomatic and Asymptomatic Antibody Mediated Rejection in Heart Transplant Recipients Olusegun Famure THE LONG-TERM CARE OF KIDNEY TRANSPLANT RECIPIENTS: WHAT IS THE ROLE OF THE GENERAL NEPHROLOGIST Oyedele Adeyi Active Sinusoidal Infiltrate and EBV Infection in Post-Liver Transplant Biopsies RK Sharma Loss of suppressive function of CD4+CD25+FOXP3+ T regulatory cells in renal patients with chronic allograft dysfunction in late post transplant period Shirin Aladwan ADVERSE SYMPTOMS OF IMMUNOSUPPRESSANTS: PILOT SURVEY OF SOLID ORGAN TRANSPLANT RECIPIENTS Tahani Alamodi KIDNEY TRANSPLANTATION IN A PEDIATRIC PATIENT WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME AND A NOVEL C3 GENE VARIANT Theone Paterson Personality factors positively predict medication adherence as measured via self-report and tacrolimus blood level post-assessment. Vanessa Michaud Transition from pediatric to adult healthcare: Evaluation of the medical and psychosocial outcomes of a Young Adult Clinic for renal transplant recipients. Yasemin Ozluk The link between recurrent glomerular diseases and allograft rejection: Under immunosuppression

7 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 6PM) GRAND BALLROOM CD Alison Gareau Serum proteins are significantly upregulated in patients with clinical antibody-mediated rejection Asami Takeda Pathological diagnosis of subclinical chronic antibody-mediated rejection in kidney allografts with de novo positive donor-specific antibodies – usefulness of C4d positivity in glomerular capillaries Berna Yelken The impact of repeated allograft biopsies on indication of Eculizumab rescue treatment in patients with serious antibody mediated rejection Bing Yang PRE-EXISTING ANTI-LG3 ANTIBODIES AGGRAVATE RENAL ISCHEMIA-REPERFUSION INJURY AND CORRELATE WITH AN INCREASED RISK OF DELAYED GRAFT FUNCTION Boris Gala-Lopez Anti-aging Glycopeptide Protects Human Islets Against Tacrolimus-related Injury and Facilitates Engraftment Daisuke Toki Interstitial Fibrosis is the Critical Determinant of Impaired Renal Function in Transplant Glomerulopathy Esme Dijke Enhanced suppressive capacity of regulatory T cells (Tregs) expanded from human thymus in the presence of rapamycin. Istvan Mucsi Ethnicity as a potential barrier to pre-transplant evaluation completion in a Canadian setting James Lan Unambiguous HLA Genotyping using Long-Range PCR and Next-Generation Sequencing (NGS) on Buccal- Extracted DNA: Results from 4,000 Donor Recruitment Samples Joseph Kim Vitamin D Levels and Post-Transplant Diabetes Mellitus After Kidney Transplantation Kasia Sablik IVIG AND HIGH DOSE STEROID TREATMENT OF TRANSPLANT GLOMERULAPATHY EFFECTIVELY SLOWS PROGRESSION OF LOSS OF RENAL ALLOGRAFT FUNCTION Minal Borkar BK polyomavirus orchestrates renal fibrosis through epigenetic modulations and induces necroptosis in renal tubular cells Patrick Luke IMMUNOSUPPRESSIVE ACTIONS OF CARBON MONOXIDE RELEASING MOLECULE (CORM-401) ON TOLL- LIKE RECEPTORS AND RENAL ISCHEMIA REPERFUSION INJURY Rahul Chanchlani Are Hypomagnesemia and Hypokalemia Novel Risk Factors for New-Onset Diabetes in Pediatric Solid Organ Transplant Recipients Renata Ponsirenas Circulating anti-HLA IgG subclasses detected after transplantation indicate subclass switching during progression of antibody-mediated rejection Sait Sen THE EFFECT OF HYPERCALCEMIA ON TUBULOINTERSTITIAL CALCIFICATION OF THE ALLOGRAFT Tomokazu Shimizu Clinical and pathological analyses of chronic vascular rejection after kidney transplantation Yasemin Ozluk Retrospective analysis of glomerulitis scoring by the last (Banff 2013) criteria: A single center observation

8 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (WED 6:30PM) GRAND BALLROOM CD An-Hang Yang The association of microvascular remodeling and expression of mesenchymal phenotypes in renal allografts with chronic active antibody-mediated rejection Ana Konvalinka Quantification of Angiotensin II Signature Proteins in Urine of Patients with Kidney Allograft Berna Yelken Are the characteristics of antibody mediated rejection predictive for the long term allograft survival? Candice Roufosse C4d positivity in renal biopsies without microcirculation inflammation or injury Chia Wei Teoh Mycophenolic acid levels are not associated with clinical adverse events at 3 months post-renal transplantation Daniel Seron Inflammation either associated or not with fibrosis at 6 week protocol biopsies is an independent predictor of 1 year DSA Dima Kabbani Vascular Jump Grafts in Liver Transplant: Do They Transmit Cytomegalovirus? Harsharan Singh Urinary Polyomavirus Haufen are Biomarkers for Polyomavirus Nephropathy: Mouse & Man & Proof of Concept Holly Mansell ELEVATED CIRCULATING INTERLEUKIN 33 LEVELS IN STABLE RENAL TRANSPLANT RECIPIENTS AT HIGH RISK FOR CARDIOVASCULAR EVENTS Karen Sherwood TOWARDS CLINICAL NGS HLA-TYPING: A PERFORMANCE COMPARISON OF NEXT-GENERATION SEQUENCING TECHNOLOGIES FOR DNA HLA TYPING IN A CLINICAL DIAGNOSTIC ENVIRONMENT Maria Cristina Ribeiro de Castro Microcirculation inflammation in early surveillance renal biopsy in sensitized patients did not correlate with graft outcome. Melanie Dieude Tissue injury enhances circulating levels of active proteasome and triggers anti-LG3 production Muhtashim Mian Evaluation of a Novel Global Immunity Assay to Predict Clinical Outcomes in Organ Transplant Recipients Natalie Montwill Iron-dependent ferroptosis mediates microvascular endothelial cell survival following cardiac allograft transplantation Roslyn Mannon The Missing Link in Kidney Allograft Loss: Renal Fibroblast Activation by Anti-Class I MHC Antibody Sacha De Serres Longitudinal Assessment of the Phenotype and Function of Monocytes in De Novo Kidney Transplant Recipients Trana Hussaini HCV Infection Interaction with Gender and Calcineurin Inhibitor Induced Chronic Renal Failure in Liver Transplant Recipients: A Case-Control Study Walter Park 120 Protocol Renal Allograft Biopsies at 10 Years Suggest New “Causes” of Chronic Injury Yasemin Ozluk Microcirculation inflammation and arteriolar hyalinosis predict graft loss in renal transplants without extensive scarring

9 THURSDAY, OCTOBER 8, 2015

2015 STATUS REPORT ON ABMR (BREAKFAST PROVIDED WITH SUPPORT FROM ASTELLAS PHARMA INC.) GRAND BALLROOM AB + PASSAGE (MODERATORS: ED KRAUS, CHRIS WIEBE) Start End Description Patricia Campbell 07:00 07:20 Epidemiology of ABMR Mark Haas 07:20 07:40 Pathophysiology and Diagnostics of ABMR Alex Loupy 07:40 08:00 Risk Stratification and Disease State Assessment in ABMR POSTER SETUP GRAND BALLROOM CD Start End Description 07:00 09:30 Thursday Poster Boards – Poster Setup

ALLIED HEALTH GROUP – CANRESTORE MEETING GULF ISLANDS BCD Start End Description 08:00 10:00 External Meeting

JOINT PLENARY SESSION #2: FROM BASICS TO THERAPEUTICS IN ABMR GRAND BALLROOM AB + PASSAGE (MODERATORS: HEINZ REGELE, PAUL KEOWN) Start End Description Stuart Knechtle 08:00 08:30 Improving Our Understanding of ABMR: What Are The Lessons From Non-Human Primate Models? Nicole Valenzuella 08:30 08:50 The Role of Macrophages in ABMR Luis G. Hidalgo 08:50 09:10 Targeting ADCC and NK Cells in ABMR David Rush 09:10 09:30 Clinical Relevance of Subclinical/Indolent Kidney Rejection Phenotypes Coffee Break among Posters Denis Glotz 10:00 10:20 What Are Our Surrogates for Treatment Efficacy in ABMR? Stan Jordan 10:20 10:40 Complement Blockade in ABMR: Results and Perspectives Robert Montgomery 10:40 11:00 Protocols for Preventing/Treating ABMR: Results and Perspectives JOINT ORAL ABSTRACT PRESENTATIONS - SESSION II GRAND BALLROOM AB + PASSAGE (MODERATORS: JAG GILL, MICHAEL MENGEL) Start End Description Jussi Tikkanen 11:00 11:10 De novo DQ-donor-specific antibodies are associated with chronic lung allograft dysfunction after lung transplantation Sarah Higgins 11:10 11:20 Identifying the specific causes and the determinants of outcome in kidney recipients with Transplant Glomerulopathy: a multicenter study. Caren Rose 11:20 11:30 Should the Kidney Donor Risk Index (KDRI) be used to quantify deceased donor quality in Canada?

10 Babak Orandi 11:30 11:40 Presentation and Outcomes of C4d-Negative Antibody-Mediated Rejection After Kidney Transplantation Marie Achille 11:40 11:50 The psychology and ethics of in the context of assisted suicide in Quebec. Antoine Roux 11:50 12:00 Lung transplantation outcome is mainly driven by antibody mediated rejection LUNCH SYMPOSIUM: MINIMIZATION, COMPLIANCE AND ABMR (LUNCH PROVIDED WITH SUPPORT FROM ASTELLAS PHARMA INC.) GRAND BALLROOM AB + PASSAGE (MODERATORS: DANIEL SERON, TOM BLYDT-HANSEN) Start End Description Chris Wiebe 12:00 12:20 De novo DSA: Prevalence, Pathophysiology and Allograft Injury Beth Foster 12:20 12:40 Risk for ABMR in Adolescence: HLA-Matching, Recipient Age, and Compliance Thomas Nevins 12:40 01:00 Predictive Patterns of Early Medication Adherence in Renal Transplantation BANFF KIDNEY CONCURRENT II: DONOR SPECIFIC ANTI-HLA MEDIATED ALLOGRAFT INJURY AND BEYOND HLA JUNIOR BALLROOM CD (MODERATORS: PATRICIA CAMPBELL, ALEX MAGIL) Start End Description Mark Haas 01:00 01:30 How Many ABMR Phenotypes Do Actually Exist? Consequences for Patient Care Adriana Zeevi 01:30 02:00 Complement Binding Capacity of Anti HLA Antibodies: Multiorgan Clinical Relevance Carmen Lefaucheur 02:00 02:30 Anti HLA DSA IgG Subclasses and Distinct Allograft Injury Duska Dragun 02:30 03:00 Beyond HLA: Relevance of Other Targets Coffee Break among Posters Stuart Greenstein 04:30 05:00 Consensus Discussion #3: Definition of New Working Group: Clinico-Pathological Consensus for the Assessment of Time Zero Donor Biopsies BANFF VASCULARIZED COMPOSITE ALLOGRAFTS (VCA) JUNIOR BALLROOM AB (MODERATORS: CINTHIA DRACHENBERG, ALTON FARRIS) Start End Description Linda Cendales 01:00 01:05 Welcome & Session Goals Anil Chandraker 01:05 01:33 Histologic Features of Antibody Mediated Rejection after Face Transplantation Jean Kanitakis 01:33 02:03 Graft Vasculopathy in the Skin After a Vascularized Composite Allograft Adela Rambi Cardones 02:03 02:31 Skin in Transplantation Gerald Brandacher 02:31 02:59 Expanding the Banff VCA Criteria Coffee Break among Posters 03:30 05:00 Group Discussion CANADIAN PANCREAS GROUP BUSINESS MEETING ORCA Start End Description 01:00 5:00 Closed Meeting (Members only)

11 CST PLENARY: ID GRAND BALLROOM AB + PASSAGE (MODERATORS: ATUL HUMAR, ALISSA WRIGHT) Start End Description Nazia Selzner 01:00 01:30 New Therapies for HCV Peter Stock 01:30 02:00 Transplanting the HIV+ Patient (and HIV+/HCV+), The HOPE Act Glen Westall 02:00 02:30 Viral infection and Allograft Rejection in the Lung Atul Humar 02:30 03:00 Viral Infection and the Allograft Rejection (Non-Lung) Coffee Break among Posters CST JOINT ETHICS & CRITICAL CARE SESSION: ISSUES IN DCD DONATION GRAND BALLROOM AB + PASSAGE (MODERATORS: REBECCA GREENBERG, ADRIAN ROBERTSON) Start End Description Sonny Dhanani 03:30 03:55 Death Determination in Organ Donation Robert Sibbald 03:55 04:20 Ethical Issues in DCD Charlotte Harrison 04:20 04:45 Pediatric DCD and Lessons Learned from Debating and Implementing a DCD Policy in a Pediatric Hospital 04:45 05:30 Panel Discussion CST PHARMACIST GROUP BUSINESS MEETING & SESSION FINBACK Start End Description Joseph Kim 03:30 04:15 Immunosuppressant Exposure Variability David Taber 04:15 05:00 Medication Errors in Transplantation Trana Hussaini 05:00 05:45 Re-thinking Immunosuppression in Liver Transplantation: A Focus on Minimization 05:45 06:00 Coffee Break 06:00 07:30 Pharmacist Group Business Meeting (Members only) TTS WOMEN IN TRANSPLANTATION NETWORKING SESSION PAVILLION BALLROOM CD Start End Description 05:00 06:00 The Transplantation Society – WiTS Networking POSTER DISMANTLE GRAND BALLROOM CD Start End Description 07:00 07:30 Thursday Poster Boards – Poster Dismantle EXHIBIT HALL DISMANTLE GRAND BALLROOM CD Start End Description 07:00 011:00 Exhibition Dismantle

12 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 9:30AM) GRAND BALLROOM CD Alton Farris NK Cell Activation Characterizes Chronic Antibody Mediated Rejection Catriona Mckenzie Oral nicotinamide to reduce nonmelanoma skin cancer in renal transplant recipients: a pilot Phase 2 randomized controlled trial Daniel Fantus The impact of novel adenosine triphosphate-competitive inhibitors (TORKinibs) on alloimmunity and transplant survival G. V. Ramesh Prasad Transplantation and the Nature of the Immune Self Jessica Forcucci Grading Capillaritis (ptc) in Renal Transplant Rejection: Can Ancillary Studies Improve Interobserver Variability Karishma Kak Patient Self-reported Adherence to and Perceptions towards Immunosuppressive Medications at the Outpatient Renal Transplant Clinic Kosuke Masutani Temporal serum creatinine increase and exacerbation of tubulointerstitial inflammation in resolving polyomavirus BK nephropathy Luis G. Hidalgo GENE EXPRESSION CHANGES IN NK CELLS FOLLOWING CD16 ACTIVATION - EVIDENCE FOR CD16 ENGAGEMENT IN BIOPSIES WITH ABMR Luis G. Hidalgo MOLECULAR ASSESSMENT OF THE COGNATE EVENTS IN T CELL- AND ANTIBODY-MEDIATED REJECTION – TWO DIFFERENT CELLS WITH MANY KEY COMMON PROGRAMS Meghan Kapp Endothelial Activation and Lymphangiogenesis in Humoral Rejection of Kidney Transplants Naima Carter-Monroe DUAL LEUKOCYTE/ENDOTHELIAL STAIN FOR ASSESMENT OF ENDOCAPILLARY INFLAMMATION IN THE RENAL ALLOGRAFT Nithya Krishnan CD45 Counts in Post Perfusion Biopsy Predicts AMR Pallav Gupta Acute and Chronic calcineurin inhibitor toxicity in live renal allograft recipients: clinical and histological features Patrick Luke First Canadian Experience with DCD Simultaneous Kidney Ryan Rochon Rhabdomyolysis after Hand Assisted Laparoscopic Donor Nephrectomy: Our Centre's Experience Stephen Quigley Acute Necrotizing Pancreatitis Following Living Kidney Donation - A Case Report and Systematic Review of the Literature. Thomas Brian McGregor Right versus Left Laparoscopic Donor Nephrectomy : Initial 3 year Experience From a Single Centre Transplant Program. Xiu Qing (Jenny) Wang Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of Molecular Chimerism in Murine Neonatal Tolerance

13 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 3PM) GRAND BALLROOM CD Benjamin Adam The NanoString gene expression platform is technically robust and feasible for routine formalin-fixed paraffin- embedded transplantation pathology applications Carlos Cervera Evaluation of qualitative and quantitative Epstein-Barr virus (EBV) DNA detection in whole blood at time of Post- transplant lymphoproliferative disorder (PTLD) diagnosis Catherine Burton Age of Clearance of Passive Maternal CMV IgG in Infants Awaiting Solid Organ Transplant Christina Kaufman Graft rejection in hand transplant recipients with grade 0 skin biopsy histology Craig Hasilo Inhibition of Neutrophil Migration Enhances Early Engraftment in a Nude Mouse Model of Human Islet Transplantation Dale Lien Combined use of extended release and regular release tacrolimus in a child with cystic fibrosis and high tacrolimus trough level variability post lung transplantation Hongji Yang Combination of Novel Anti-CD45RB and Anti-CD40 Chimeric Antibodies Promotes Operational Tolerance with a Distinct Signature of Immunoregulatory Cells in Cynomolgus Monkey Renal Allograft Recipients Hyeon Joo Jeong Immunophenotype of Inflammatory Cells in Isolated V-Lesion of Allograft Kidney Jee-Young Han Clinico-pathologic characteristics of C4d negative antibody mediated rejection in renal allografts Jorge Malheiro GRAFT PATHOLOGY AND DONOR-SPECIFIC DE NOVO ALLOSENSITIZATION IN THE NATURAL HISTORY OF KIDNEY TRANSPLANTATION: A CASE-CONTROL ANALYSIS Julie Allard PATIENTS’, CAREGIVERS’ AND RESEARCHERS’ PERSPECTIVES ON RESEARCH PRIORITIES IN ORGAN TRANSPLANTATION IN CANADA. Jutta Krista Preiksaitis Residual risk of transfusion-acquired cytomegalovirus (CMV) infection in CMV seronegative solid organ transplant recipients receiving CMV seronegative organs and leukoreduced cellular blood products Olusegun Famure MEDICAL AND NON-MEDICAL PREDICTORS OF COMPLETING THE TRANSPLANT EVALUATION PROCESS IN END-STAGE RENAL DISEASE (ESRD) PATIENTS. – A SINGLE CENTRE STUDY Roslyn Mannon Understanding the Milieu of Brain Death: Donor Monocyte Chemoattractant Protein 1 (MCP-1) Predicts Recipient Allograft Function Sunita Singh The Epidemiology of Pancreta Discard: An SRTR Analysis Tariq Aljohani EBV-positive lymphoid infiltrate in a renal surveillance biopsy mimicking subclinical T-cell mediated rejection Virginie Royal Eculizumab for the treatment of severe antibody-mediated rejection: a case report and review of the literature

14 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 6PM) GRAND BALLROOM CD Benjamin Adam Internal and external validation of a molecular diagnostic for antibody-mediated rejection in routine formalin-fixed paraffin-embedded renal allograft biopsies Christina Dörje Does total inflammation in early kidney graft biopsies predict progression of fibrosis and transplant function at 1 year post-transplant? Dayanand Deo Renal Histogenomics: Gene fingerprint to predict Delayed Graft Function Elizabeth Martinez Acute Vascular Lesions in the Kidney Transplant and Relationship to Cellular and Antibody-Mediated Rejection (ABMR) Erin Ready Post-transplant lymphoproliferative disorder in adult kidney transplant patients: a British Columbia experience G. V. Ramesh Prasad TRANSPLANT TOURISM IS AN INDEPENDENT RISK FACTOR FOR LONG TERM KIDNEY ALLOGRAFT LOSS Hanneke de Kort Comparison of methods for assessment of peritubular capillary basement membrane multilayering (PTCBML) Heounjeong Go Refining the diagnostic criteria of transplant capillaropathy for chronic antibody-mediated rejection Jan Ulrich Becker Pathologists' individual approach to the diagnosis of Banff Borderline T-cell mediated rejection Joseph Kim Validation of Predictive Nomograms for Delayed Graft Function in Canadian Kidney Transplant Recipients Julie Allard Organ donation after cardiac death for a conscious patient: new ethical issues Li-Zzu Lin Primary hepatic angiosarcoma treated with living dornor liver transplantation Marie Wright Long-term respiratory morbidity in recipients of pediatric solid organ transplants: a retrospective review. Rajan Duggal Clinicopathologic spectrum of plasma cell–rich acute rejection: An aggressive morphologic form of acute rejection Ruth Sapir-Pichhadze Kidney Transplant Outcomes following Alemtuzumab Induction and a Steroid-Free Protocol vs. rATG Induction and Maintenance Steroids Seyed M Hosseini-Moghaddam Antiviral Prophylaxis against Early-Onset Post-Transplant Lymphoproliferative Disease in Epstein-Barr Virus Seronegative Renal Transplants, Single Arm Cohort Study Shaifali Sandal Renal Resistance Measured during Pulsatile Perfusion and Long-Term Kidney Transplant Outcomes Szu-Han Wang Predictors of biliary leakage after T-tube removal in living donor liver transplantation recipients

15 JOINT POSTERS & EXHIBITS: AUTHOR PRESENTATIONS (THURS 6:30PM) GRAND BALLROOM CD Alberto González-Almada Histologic Findings in Pre-transplant AT1Rab + ve Patients: Increase in Sub-intimal Fibrosis During Acute Rejection and in 12 mo. Protocol Renal Graft Biopsies. C Deblais DIFFUSE, INTENSE, LINEAR (DIL) C4d GLOMERULAR CAPILLARY POSITIVITY IS A STRONG MARKER FOR THE DIAGNOSIS OF CHRONIC ANTIBODY MEDIATED REJECTION. Erik Larsson Systematic morphological evaluation of consecutive protocol biopsies of the duodenal cuff in clinical pancreas transplantation Farsad-Alexander Eskandary The prevalence of late HLA-DSA-positive antibody-mediated rejection in kidney transplant recipients and the diagnostic value of antibody properties: Results of a large prospective cross-sectional study Istvan Mucsi Mental health and behavioral barriers to completing the pre-transplant evaluation Istvan Mucsi African Canadian and Asian Canadian patients are less likely to have potential living donors when first presenting for evaluation: A single center experience James Lan Clinical Relevance of Complement-Activating Donor-Specific Antibodies Identified by a Novel C3d Assay in Predicting Kidney Allograft Failure Johan Molne Rejection patterns and a grading system for cervical biopsies after human transplantation Joseph Kahwaji Pathological Finidngs in HLA Sensitized Patients Treated with Everolimus: Interim Results Joseph Kim Incidence, Risk Factors, and Clinical Outcomes of BK Virema in the Modern Era of Kidney Transplantation Kyla Naylor Frequency of Bone Mineral Density Testing in Adult Kidney Transplant Recipients Marie-Chantal Fortin Patients’ Perspectives on Cardiovascular Risk Factors after Kidney Transplantation Michael Moser Early experience with machine cold perfusion of living donor kidneys Nada Alachkar IgA nephropathy recurrence after kidney transplantation Ngan Lam Gender Differences in Use of Prescription Narcotic Medications among Living Kidney Donors Rhea Varughese A Single Centre’s Lung Transplantation Experience for Pulmonary Graft versus Host Disease Shigeo Hara Granular swollen epithelial cells in the kidney allograft: a marker for kidney allograft senescence? Sunita Singh External Validation of Clinical Prediction Models of Patient and Graft Survival in a Canadian Cohort of Kidney Transplant Recipients

16 FRIDAY, OCTOBER 9, 2015

PUBLIC SOLICITATION AND DIRECTED ANONYMOUS DONATION SYMPOSIUM GRAND BALLROOM AB + PASSAGE (MODERATOR: STEVEN PARASKEVAS) Start End Description 07:00 08:00 Breakfast Symposium BANFF SUMMARY PAVILLION BALLROOM D Start End Description 08:00 12:00 Banff Summary CST LIVER CONCURRENT SESSION JUNIOR BALLROOM B (MODERATORS: IAN ALWAYN, MARKUS SELZNER) Start End Description 08:00 09:00 Sandy Feng Liver Transplantation for HCC-Milan, UCSF, TTV: Where do we go? 09:00 09:15 Karen Pineda-Solis “Functional” Warm Ischemia Time as a Predictor of Graft Failure and Biliary Complications. 09:15 09:30 Juan Echeverri Subnormothermic Ex-Vivo Liver Perfusion (SNEVLP) Reduces Endothelial Cell Damage and Bile Duct Injury after Pig Liver Transplantation with HBD Grafts 09:30 09:45 David Forner Donor Specific Antibodies in Liver Transplantation: Do Complement Fixing Antibodies Predict Outcomes? 09:45 10:00 Ahmed Alqallaf Correlation of Serum Creatinine-Based Equations With Radionuclide GFR in Candidates for Liver Transplantation 10:30 10:45 Nazia Selzner Debate: Is six months abstinence required for liver transplantation in patients with alcohol induced liver disease? PROS 10:45 11:00 James Shapiro Debate: Is six months abstinence required for liver transplantation in patients with alcohol induced liver disease? CONS 11:00 11:15 Juan Echeverri Live Donor Liver Transplantation with Older (>50years) vs Younger (<50years) Donors: Does Age Matter? 11:15 11:30 Trana Hussaini Immunosuppression practices in liver transplantation: A survey of North American Centres 11:30 11:45 Juan Echeverri Fast Track of Adult-to-Adult Live Donor Liver Transplant Recipients: Avoiding ICU Admission Reduces Complications and Post Transplant Hospital Stay 11:45 12:00 Ibrahim Al Hasan The Fate of the DCD Liver Follows the Kidney CST LUNG CONCURRENT SESSION JUNIOR BALLROOM A (MODERATOR: LIANNE SINGER) Start End Description 08:00 08:45 Glen Westall Making Sense of Antibodies before and after Lung Transplantation 08:45 09:30 Jussi Tikkanen Antibodies in Lung Transplantation - What do we know and what can we do? 09:30 09:40 Alim Hirji Clinical Judgment Versus in Predicting Waitlist Mortality 09:40 09:50 Nader Aboelnazar The Value of Hypoxic Pulmonary Vasoconstriction in Determining Lung Health During Ex- Vivo Lung Perfusion

17 09:50 10:00 Katie Kinaschuk Evolving strategies for Mechanical Circulatory Support in Bridging prior to Lung Transplantation 10:30 10:40 Sunita Mathur Persistent Skeletal Muscle Weakness And Atrophy After Lung Transplantation 10:40 10:50 Dale Lien Donor Specific Antibody (DSA) Associated With Significant Bilateral Upper Lobe Pleural Thickening And Lung Graft Dysfunction CST-CSN JOINT KIDNEY-PANCREAS CONCURRENT SESSION PAVILLION BALLROOM C (MODERATORS: RAMESH PRASAD, JAG GILL) Start End Description 08:00 08:40 Hatem Amer Treasure in the Waste-Post Transplant Proteinuria 08:40 09:20 G. V. Ramesh Prasad Metabolic Syndrome, Chronic Kidney Disease, and Transplantation 09:20 10:00 Greg Knoll Post-Transplant Malignancy 10:30 10:40 Cecilia Kwok Caspase-8 has paradoxical function in ischemia-reperfusion injury versus transplantation due to differences in intracellular pH 10:40 10:50 Melanie Dieude The 20S proteasome activity within apoptotic nanovesicles controls immune responses to the allograft 10:50 11:00 Ryan Cunnington Epithelial-to-Mesenchymal transition as a mechanism for BK virus induced kidney fibrosis 11:00 11:10 Kevin Wen IgA Nephropathy: HLA Class II zero mismatch living donor kidney transplantation associated with increased recurrence and graft loss 11:10 11:20 Sunita Singh Is Delayed Graft Function in Simultaneous Kidney-Pancreas Transplant Recipients Associated with an Increased Risk of Pancreas Graft Failure? 11:20 11:30 Olusegun Famure Neighbourhood-level socioeconomic predictors for completing the assessment and progressing to kidney transplant among referred end-stage renal disease patients 11:30 11:40 Ye Su Loss of RIPK3 and Caspase-8 Enhance Intrinsic Apoptosis in Tubular Epithelial Cell (TEC) Death and Contributes to Kidney Ischemia Reperfusion Injury (IRI) 11:40 11:50 Michael Moser Protection of the transplant kidney from preservation injury by inhibition of matrix metalloproteinases 11:50 12:00 Tom Blydt-Hansen Urine metabolites as biomarkers for kidney antibody-mediated rejection 12:00 12:10 Gaurav Tripathi Genetic Predisposition to Interleukin-10 production influences Epstein–Barr Virus Reactivation after Renal Transplantation CST DONATION CONCURRENT SESSION PAVILLION AB (MODERATOR: ADRIAN ROBERTSON) Start End Description 08:30 09:15 Adrian Robertson Space and Time of Discussions with Donor Families. 09:15 10:00 Sonny Dhanani Donation Physician Specialists 10:30 11:00 Robert Sibbald Consent to Donation is Trickier Than it Looks

18 11:00 11:10 Michael Moser What messages are potential donor families receiving from the Internet about Donation after Cardiac Death? 11:10 11:20 Daniel Buchman Organ Donation after Physician Assisted Death in Canada: Ethical and Legal Issues 11:20 11:30 Elizabeth Hendren Where should the public learn about organ donation: Health Care Settings or the DMV? 11:30 11:40 Samantha Anthony Family Veto in Organ Donation 11:40 11:50 Caren Rose The number of HIV-infected potential deceased organ donors in Canada 11:50 12:00 Maeghan Toews Family Override of Consent for Organ Donation: The Disconnect between Law and Policy 12:00 12:10 Sonny Dhanani Increase In Neurologic Determination Of Death (NDD) Organ Donation In The Donation After Cardiac Death (DCD) Era. The Ontario Experience. CST HEART CONCURRENT SESSION JUNIOR BALLROOM C (MODERATORS: LORI WEST, BRUCE MCMANUS) Start End Description 09:00 09:30 Bruce McManus Biomarkers for Monitoring Cardiac Allograft Rejection: Ready for Prime Time? 09:30 10:00 Michael Mengel Antibody Mediated Rejection in Heart Transplantation: What Is The Diagnostic Gold Standard in 2015? 10:30 10:42 Xusheng Zhang Prolongation of Cardiac Allograft Survival through Targeted Silencing of TLR Adaptor Genes using Mannose Liposome 10:42 10:54 Medhat Askar Association of Complement Activation Product C5a with Allosensitization in Patients with Ventricular Assist Devices 10:54 11:06 Ye Su Intracellular OPN is an essential protective factor to cardiac endothelial cell and the long term heart graft survival 11:06 11:18 Stanley Araujo Reactivation Chagoma in Heart Transplanted patients 11:18 11:30 Mark Kearns Donor Death and Cardiac Injury After Withdrawal of Life Support in a Rodent DCD Protocol 11:30 11:42 Bruce Motyka Tolerance to A-Antigen Following ABO-Incompatible Heart Transplantation (HTx) in a Blood Group A-Transgenic Mouse Model 11:42 11:54 Cecilia Kwok CD4+ T-cell mediated microvascular endothelial cell death in a chronic cardiac allograft rejection model involves RIPK3 11:54 12:06 Romy Hoeppli Tailoring Homing Capacity of Thymic Regulatory T Cells by Expansion in Cytokine-enriched Culture Conditions CST RESEARCH COMMITTEE MEETING GULF ISLANDS BCD Start End Description 12:30 01:30 External Meeting CNTRP SESSION GRAND BALLROOM AB + PASSAGE Start End Description 01:00 02:00 Canadian National Transplant Research Program Session

19 CST FELLOWSHIP PRESENTATION GRAND BALLROOM AB + PASSAGE (MODERATOR: RAMESH PRASAD) Start End Description 02:00 02:15 Esme Dijke Transplantation in infancy: exploring pathways to tolerance induction PANEL ON QUALITY IN TRANSPLANTATION GRAND BALLROOM AB + PASSAGE (MODERATORS: PROSANTO CHAUDHURY, JOHN GILL) Start End Description 02:30 02:50 Greg Knoll An introduction to Quality. What is Quality? How does one measure it? 02:50 03:10 Dorry Segev What is being done in the US? Program specific reporting (PSR) and how it works. 03:10 03:30 Stuart Greenstein TransQIP and beyond 03:30 04:00 Panel Discussion 04:00 04:15 Coffee Break CST ANNUAL GENERAL MEETING GRAND BALLROOM AB + PASSAGE Start End Description 04:15 05:45 Closed Meeting (Members only) CST BOARD MEETING GULF ISLANDS BCD Start End Description 06:00 06:30 Closed Meeting (Members only) CONFERENCE DINNER & AWARDS GALA PAVILLION BALLROOM CD Start End Description 07:30 10:00 Ticketed Social Event

SATURDAY, OCTOBER 10, 2015 CST LUNG GROUP BUSINESS MEETING PORT ALBERNI Start End Description 09:00 12:00 Closed Meeting (Members only)

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