Supplementary material BMJ Open

Supplementary-file-2 Ethics committees’ names and approval registration number NO. Hospital Ethics committee name Approval number Independent Ethics Committee for Clinical Research of Zhongda Hospital, Affiliated 1 Zhongda Hospital, 2017ZDSYLL025-P01 with Southeast University 2 Yantai Yuhuangding Hospital Medical Ethics Committee of Yantai Yuhuangding Hospital [2017]No. 17 Friendship Hospital Affiliated with Medical Ethics Committee of Beijing Friendship Hospital Affiliated with Capital 3 2017-P2-083-02 Capital Medical University Medical University 4 Northern People’s Hospital Medical Ethics Committee of Northern Jiangsu People’s Hospital 2017045 The First Affiliated Hospital of 5 Ethics Committee of The First Affiliated Hospital of Chongqing Medical University 20172501 Medical University 6 Yantaishan Hospital, Yantai The Clinical Trial Ethics Committee of Yantaishan Hospital 2017004 The Affiliated Hospital of University of Medical Ethics Committee of The Affiliated Hospital of Henan University of Science 7 2017-0044 Science and Technology and Technology 8 Provincial People’s Hospital Medical Ethics Committee of Zhejiang Provincial People’s Hospital 2017KY019 The Second Affiliated Hospital of Harbin Medical Ethics Committee of the Second Affiliated Hospital of Harbin Medical 9 KY2017-241 Medical University University Shenzhen Hospital of Traditional Chinese 10 Medical Ethics Committee of Shenzhen Hospital of Traditional Chinese Medicine (2017)18 Medicine 11 Medical University General Hospital Medical Ethics Committee of Tianjin Medical University General Hospital IRB2017-130-01 The First Affiliated Hospital of Nanjing Medical 12 Ethics Committee of the First Affiliated Hospital of Nanjing Medical University 2017-SR-215 University (Jiangsu Province People’s Hospital) 13 Zhongshan Hospital, Medical Ethics Committee of Zhongshan Hospital, Fudan University B2017-138 The First Affiliated Hospital of Nanchang Ethics Committee for Medical Research of the First Affiliated Hospital of Nanchang 14 2017-059 University University

Liu S, et al. BMJ Open 2019; 9:e028664. doi: 10.1136/bmjopen-2018-028664 Supplementary material BMJ Open

NO. Hospital Ethics committee name Approval number Chinese PLA Rocket General Hospital (Second 15 Ethics Committee of Second Artillery General Hospital PLA KY2017016 Artillery General Hospital PLA) 16 Tianjin Third Central Hospital Medical Ethics Committee of Tianjin Third Central Hospital IRB2017-011-01 17 Zhongnan Hospital of Medical Ethics Committee of Zhongnan Hospital of Wuhan University 2017020 The First Affiliated Hospital of Medical Ethics Committee for Medical Science Research of the First Affiliated Hospital of 18 2017-166-2 University China Medical University 19 The First People’s Hospital of Foshan Medical Ethics Committee of the First People’s Hospital of Foshan 2017-8 20 First Hospital of Medical University Ethics Committee of First Hospital of Shanxi Medical University 2017-K030 Central Hospital Affiliated to Shenyang Medical 21 Medical Department of Central Hospital Affiliated to Shenyang Medical College NO College Xinhua Hospital Affiliated with Jiao Xinhua Hospital Ethics Committee Affiliated with Shanghai Jiao Tong University 22 XHEC-C-2017-046-2 Tong University School of Medicine School of Medicine 23 Qilu Hospital of University (Qingdao) Ethics Committee of Qilu Hospital of (Qingdao) NO 24 Wuhan General Hospital of Guangzhou Military Medical Ethics Committee of Wuhan General Hospital of Guangzhou Military [2017]023-1 25 Henan Province People's Hospital Medical Ethics Committee of Henan Province People's Hospital 2017(56) Affiliated Hospital of Medical Ethics Committee for Drug Clinical Trials of Affiliated Hospital of Guizhou Medical 26 2017-135 University University 27 China- Friendship Hospital Ethics Committee for Clinical Research of China-Japan Friendship Hospital 2017-110 First Affiliated Hospital, University Ethics Committee of First Affiliated Hospital, of Chinese 28 HZYLLKY201700601 of Chinese Medicine Medicine 29 The First Hospital of University Ethics Committee of The First Hospital of 2017-327 30 Provincial People’s Hospital Medical Ethics Committee of Hunan Provincial People’s Hospital [2018]-03 31 Shanghai General Hospital Shanghai General Hospital Institutional Review Board [2018]02 32 Shanghai Changzheng Hospital Medical Ethics Committee of Shanghai Changzheng Hospital 2018SL005

Liu S, et al. BMJ Open 2019; 9:e028664. doi: 10.1136/bmjopen-2018-028664 Supplementary material BMJ Open

NO. Hospital Ethics committee name Approval number The Third Xiangya Hospital of Central South 33 Institutional Review Board of The Third Xiangya Hospital of R17020 University The Affiliated Hospital of 34 Ethics Committee of The Affiliated Hospital of Inner Mongolia Medical University 2017(016) Medical University The First Affiliated Hospital of Zhengzhou Ethics Committee for Scientific Research and Clinical Trials of the First Affiliated 35 Drug-2017-85 University Hospital of First Affiliated Hospital of the Air Force Medical Independent Ethics Committee for Drug Clinical Trials of First Affiliated Hospital of 36 University (First Affiliated Hospital of Fourth KY20172100-1 Fourth Military Medical University Military Medical University) Scientific Research Institutional Review Board of Yijishan Hospital of Wannan 37 Yijishan Hospital of Wannan Medical College 2018(04) Medical College 38 Shanghai Sixth People's Hospital Ethics Committee of Shanghai Sixth People's Hospital 2018-012 The North Hospital of Ruijin Hospital Affiliated Ethics Committee of The North Hospital of Ruijin Hospital Affiliated with Shanghai 39 with Shanghai Jiao Tong University School of 2018(009)-1 Jiao Tong University School of Medicine Medicine Peking Union Medical College Hospital of the Institutional Review Board of Peking Union Medical College Hospital of the Chinese 40 B248 Chinese Academy of Medical Sciences Academy of Medical Sciences First Affiliated Hospital of Kunming Medical 41 Ethics Committee of First Affiliated Hospital of Kunming Medical University 2018-12 University 42 The First Hospital of Ethics Committee for Drug Clinical Trials of The First Hospital of Lanzhou University 2018-13 43 Chinese PLA General Hospital Medical Ethics Committee of Chinese PLA General Hospital S2018-011-01 44 Yanbian University Hospital Medical Ethics Committee of Yanbian University Hospital 2018138 45 The Affiliated Hospital of Qingdao University Medical Ethics Committee of The Affiliated Hospital of Qingdao University QYFYKYLL 2018-20

Liu S, et al. BMJ Open 2019; 9:e028664. doi: 10.1136/bmjopen-2018-028664