Table 1: Ingenuity Functional Classes Found Enriched Upon

Table 1: Ingenuity functional classes found enriched upon treatments Time -log2(max Max Min Treatment (hrs) Function significance) significance significance Genes CD93,NCF1,CCR1,CD38,TNFRSF10B,CDKN2D,MYC,OSM, INHBB,CD79A, IFI30,PLAU,ALOX5AP,MMP9,CEBPB,MDK,SOCS1,ITGB7,IRF1,CCL2,BC Immune L2, ATRA 8 Response 37.2 6.35E-12 1.77E-03 G1P3,FGR,MYB,PLCB2,CEBPE,NP CD93,CCR1,NCF1,PTGES,CD38,PRG2 (includes EG:5553),CTSD,CD79A, PRAM-1,PLAU,PSMB9,ALOX5AP,CEBPB,MDK,ITGB7,IRF1,CCL2,CST7, Immune G1P3,DEFA1 (includes EG:1667),FGR,CD300A,CTSG,TGM2,PLCB2, ATRA 24 Response 42.6 1.51E-13 5.84E-03 CEBPE CXCR4,PIK3CG,S100A9,CD93,LY6E,NOTCH1,CCR1,CDKN1A,PTGES, ADORA3,BPI,CD38,INPP5D,CDKN2D,MYC,INHBB,PRAM-1,TNFRSF1B, ZFP36L1,PLAU,PTAFR,PSMB9,SPP1,LCP2,IL18R1,FYN, PTGS1,NCF4,ITGB7,TERT,ADORA2A,GAB2,CST7,MPO,CD300A,FGR, CTSG,SELPLG,AIF1,ITGAM,TRIM22,SPI1,NCF1,CTSS,IL18RAP,ITGAX, PRG2 (includes EG:5553),XBP1,ETV6,CD79A,CTSD,ALOX5AP,CCND1, Immune MDK,TNFRSF14,CEBPB,CHST4,MAD1L1,TAPBP,CCL2,SIRPA,TYROBP, ATRA 48 Response 75.8 1.54E-23 1.15E-04 BCL2,G1P3,DEFA1 (includes EG:1667),TGM2,PLCB2,MYB,CEBPE,WT1 Immune ATORVASTATIN 8 Response 9.0 1.94E-03 1.94E-03 ZC3HAV1 Immune ATORVASTATIN 24 Response 24.5 4.19E-08 4.21E-02 CCL3L1,JUND,PLAU,KLF2,ANXA1,IL8 Immune FCER1G,NFKBIA,JUND,ADM,IL32,TXNIP,ABCA1,DPYSL2,MMP9, ATORVASTATIN 48 Response 19.3 1.56E-06 2.89E-03 CDKN1A,ANXA1 CCR1,NCF1,CD38,IL8,CDKN2D,MYC,INHBB,CD79A,PRAM-1,IFI30,PLAU, Immune ALOX5AP,CEBPB,MDK,SOCS1,ITGB7,CCL2,IRF1,BCL2,G1P3,FGR, ATRA+ATORVASTATIN 8 Response 33.3 9.21E-11 1.38E-03 ZC3HAV1,MYB,PLCB2,CEBPE,NP CD97,PIK3CG,CD93,LY6E,CCR1,PTGES,CD38,CDKN2D,MYC,TREM1, BCL6,INHBB,ANXA1,PRAM-1,CALR,JUND,PLAU,PTAFR,PSMB9,PTGS, ITGB7,TERT,IRF1,KLF2,CST7,FGR,CD300A,CTSG,ZC3HAV1,SELPLG, Immune CCL4,CSF1R,ITGAM,SPI1,NCF1,IL8,PECAM1,ITGAX,PRG2 ATRA+ATORVASTATIN 24 Response 71.9 2.20E-22 3.19E-04 (includes EG:5553),CD79A,IFI30,ABCA1, SERPINA1,CD97,CD48,PIK3CG,NFKBIZ,S100A9,CYBB,LY6E,NOTCH1, TXNIP,CCR1,CDKN1A,PTGES,CCL20,CD38,PTPN6,INPP5D,NFKBIA, CDKN2D,MYC,TREM1,BCL6,INHBB,ANXA1,PAK1,JUND,MYD88,CARD12 , Immune PRDX5,SPP1,GGTLA1,FYN,CCL23,PTGS1,NCF4,ITGB7,TERT,IMPDH2, ATRA+ATORVASTATIN 48 Response 149.3 1.16E-45 3.24E-06 GAB2,CST7,C3,MPO,CD300A,FGR,Z Hematological System BCL2A1,CD93,CCR1,ID2,CD38,TNFRSF10B,CDKN2D,MYC,OSM,CD79A, Development ELF4,PLAU,SLA,NFE2,ALOX5AP,MMP9,MDK,CEBPB,SOCS1,ITGB7, ATRA 8 and Function 61.3 3.53E-19 1.77E-03 BCL11A,CCL2,IRF1,BCL2,FGR,MYB,PLCB2,CEBPE,ID1,NP,THBD BCL2A1,CD93,CCR1,ID2,PTGES,CD38,CDKN2D,PRG2 (includes EG:5553), Hematological CD79A,ELF4,PLAU,SLA,ALOX5AP,MDK,CEBPB,ITGB7,BCL11A,TERT,IR System F1, CCL2,DEFA1 (includes Development EG:1667),FGR,CD300A,TGM2,CTSG,PLCB2,CEBPE, ATRA 24 and Function 38.6 2.46E-12 5.76E-03 THBD Hematological CXCR4,PIK3CG,BCL2A1,S100A9,CD93,LY6E,NOTCH1,CCR1,CDKN1A, ATRA 48 System 98.2 2.75E-30 1.27E-04 PTGES,ADORA3,BPI,CD38,INPP5D,CDKN2D,BAK1,MYC,TNFRSF1B, Development ZFP36L1,PLAU,SPP1,LCP2,FYN,ITGB7,TERT,ADORA2A,IRF1,GAB2,MP and Function O, FGR,CTSG,SELPLG,ITGAM,SPI1,SATB1,ID2,IL18RAP,CTSS,ITGAX, PRG2 (includes EG:5553),XBP1,EGR1,CD79A,CASP9,ETV6,ELF4,SLA, ALOX5AP,CCND1,TNFRSF14,MDK,CEBPB,CHST4,ANXA2,BCL11A, MAD1L1,TAPBP,CCL2,SIRPA,TYROBP,BCL2,DEFA1 (includes EG:1667), TGM2,PLCB2,MYB,CEBPE,WT1,THBD Hematological System Development ATORVASTATIN 8 and Function 0.0 1.00E+00 1.00E+00 NA Hematological System Development ATORVASTATIN 24 and Function 31.6 3.03E-10 4.21E-02 CCL3L1,JUND,PLAU,KLF2,THBD,IL8,ANXA1 Hematological System Development FCER1G,NFKBIA,JUND,TXNIP,ABCA1,DPYSL2,MMP9,CDKN1A,EGR1, ATORVASTATIN 48 and Function 27.8 4.42E-09 3.29E-03 THBD,ANXA1 Hematological System BCL2A1,CCR1,ID2,IL8,CD38,CDKN2D,MYC,CD79A,CASP9,ELF4,PLAU, Development SLA,ALOX5AP,NFE2,CEBPB,MDK,SOCS1,ITGB7,BCL11A,CCL2,IRF1, ATRA+ATORVASTATIN 8 and Function 58.3 2.78E-18 1.14E-03 BCL2,FGR,MYB,PLCB2,CEBPE,ID1,NP,THBD PIK3CG,BCL2A1,CD93,LY6E,CCR1,PTGES,CD38,CDKN2D,MYC,TREM1, Hematological BCL6,ANXA1,CALR,JUND,PLAU,ITGB7,TERT,IRF1,KLF2,FGR,CD300A, System CTSG,ID1,SELPLG,CCL4,CSF1R,ITGAM,SPI1,ID2,IL8,PECAM1,ITGAX, PRG2 (includes Development EG:5553),CD79A,ELF4,ABCA1,SLA,ALOX5AP,NFE2,MDK, ATRA+ATORVASTATIN 24 and Function 65.2 2.39E-20 3.25E-04 TNFRSF14,CEBPB,BCL1 Hematological SERPINA1,CD48,PIK3CG,BCL2A1,S100A9,CYBB,TXNIP,NOTCH1,LY6E, System CCR1,CDKN1A,PTGES,CCL20,CD38,PTPN6,INPP5D,CDKN2D,NFKBIA, BAK1,MYC,TREM1,CARM1,BCL6,ANXA1,PAK1,JUND,MYD88,SPP1, Development GGTLA1,CCL23,FYN,ITGB7,TERT,APAF1,IMPDH2,C3,GAB2,MPO,FGR, ATRA+ATORVASTATIN 48 and Function 145.6 1.47E-44 3.29E-06 IL1B,CSF1R,PROS1,SPI1,SATB1,PTP ELF4,PLAU,BCL2A1,SLA,MMP9,CEBPB,MDK,RARRES3,SOCS1,ID2, Tissue ITGB7,CD38,IRF1,CCL2,CDKN2D,MYC,OSM,BCL2,IRX3,MYB,ID1,NP, ATRA 8 Morphology 61.3 3.53E-19 7.54E-04 CD79A Tissue ELF4,PLAU,BCL2A1,SLA,MDK,CEBPB,RARRES3,NCF1,ID2,ITGB7,CD38, ATRA 24 Morphology 35.8 1.73E-11 5.76E-03 TERT,IRF1,CCL2,CDKN2D,CTSG,VIM,CD79A,CTSD CXCR4,PIK3CG,BCL2A1,S100A9,ITGAM,NOTCH1,SATB1,SPI1,RARRES 3, CDKN1A,ID2,ADORA3,CTSS,CD38,INPP5D,CDKN2D,BAK1,MYC,XBP1, EGR1,CASP9,ETV6,CD79A,TNFRSF1B,ELF4,PLAU,GDF15,SPP1,SLA, Tissue LCP2,FYN,CCND1,MDK,CEBPB,CHST4,ITGB7,TERT,GGT1,CCL2,IRF1, ATRA 48 Morphology 98.2 2.75E-30 4.49E-05 SIRPA,TYROBP,BCL2,GAB2,IRX3,MYB,SELPLG Tissue ATORVASTATIN 8 Morphology 0.0 1.00E+00 1.00E+00 NA Tissue ATORVASTATIN 24 Morphology 16.1 1.41E-05 1.07E-02 PLAU,KLF2,IL8 Tissue ATORVASTATIN 48 Morphology 27.8 4.42E-09 3.05E-03 FCER1G,NFKBIA,ADM,TXNIP,ABCA1,MMP9,S100A10,CDKN1A,EGR1 Tissue ELF4,PLAU,BCL2A1,SLA,CEBPB,MDK,RARRES3,SOCS1,ID2,ITGB7,IL8, ATRA+ATORVASTATIN 8 Morphology 58.3 2.78E-18 9.22E-04 CD38,IRF1,CCL2,CDKN2D,MYC,BCL2,IRX3,MYB,ID1,NP,CD79A,CASP9 PIK3CG,CSF1R,BCL2A1,ITGAM,SPI1,RARRES3,ID2,CD38,IL8,CDKN2D, MYC,PECAM1,BCL6,CTSD,CASP9,CD79A,ELF4,PLAU,ABCA1,SLA,MDK, Tissue CEBPB,ITGB7,TERT,FCER1G,IRF1,CCL2,KLF2,TYROBP,BCL2,IRX3, ATRA+ATORVASTATIN 24 Morphology 62.9 1.17E-19 3.25E-04 BHLHB2,CTSG,ID1,SELPLG SERPINA1,CXCR4,PIK3CG,S100A9,BCL2A1,CYBB,LYN,NOTCH1,TXNIP, CD22,CDKN1A,ADORA3,CD38,PTPN6,INPP5D,CDKN2D,NFKBIA,MYC, BAK1,CARM1,BCL6,TNFSF13B,TNFRSF1B,MYD88,PLAU,CXCL10,SPP1, Tissue TAP1,LCP2,FYN,CCL3,ITGB7,TERT,APAF1,IRF1,KLF2,GAB2,C3,IRX3, ATRA+ATORVASTATIN 48 Morphology 145.6 1.47E-44 2.36E-06 CTSG,SELPLG,IL1B,CSF1R,ITG Immune and Lymphatic System BCL2A1,CD93,CCR1,ID2,CD38,TNFRSF10B,CDKN2D,MYC,OSM,CD79A, Development ELF4,PLAU,SLA,NFE2,MMP9,MDK,CEBPB,SOCS1,ITGB7,BCL11A,CCL2, ATRA 8 and Function 59.0 1.68E-18 1.21E-03 IRF1,BCL2,FGR,MYB,CEBPE,ID1,NP,THBD Immune and Lymphatic BCL2A1,CD93,CCR1,ID2,PTGES,CD38,CDKN2D,PRG2 (includes System EG:5553), CD79A,PRAM- Development 1,ELF4,PLAU,PSMB9,NFE2,SLA,MDK,CEBPB,ITGB7,BCL11A,TERT,IRF1 ATRA 24 and Function 35.8 1.73E-11 5.76E-03 ,CCL2,CD300A,FGR,CTSG,CEBPE,THBD CXCR4,PIK3CG,BCL2A1,S100A9,CD93,NOTCH1,LY6E,CDKN1A,CCR1, PTGES,BPI,ADORA3,CD38,INPP5D,CDKN2D,MYC,TNFRSF1B,PRAM-1, Immune and ZFP36L1,PLAU,PSMB9,SPP1,LCP2,FYN,ITGB7,TERT,ADORA2A,IRF1, Lymphatic GAB2,MPO,FGR,CD300A,CTSG,SELPLG,ITGAM,SPI1,SATB1,ID2,CTSS, System IL18RAP,ITGAX,PRG2 (includes EG:5553),XBP1,EGR1,CD79A,ETV6,ELF4, Development SLA,CCND1,MDK,TNFRSF14,CEBPB,CHST4,ANXA2,BCL11A,MAD1L1, ATRA 48 and Function 87.2 5.66E-27 1.05E-04 TAPBP,CCL2,SIRPA,TYROBP,BCL2,TGM2,MYB,CEBPE,WT1,THBD Immune and Lymphatic System Development ATORVASTATIN 8 and Function 0.0 1.00E+00 1.00E+00 NA Immune and Lymphatic System Development ATORVASTATIN 24 and Function 31.6 3.03E-10 4.21E-02 CCL3L1,JUND,PLAU,KLF2,THBD,ANXA1,IL8 Immune and Lymphatic System Development FCER1G,NFKBIA,JUND,TXNIP,ABCA1,MMP9,CDKN1A,EGR1,THBD, ATORVASTATIN 48 and Function 27.8 4.42E-09 3.29E-03 ANXA1 Immune and Lymphatic System BCL2A1,CCR1,ID2,CD38,IL8,CDKN2D,MYC,CD79A,PRAM-1,ELF4,PLAU, Development NFE2,SLA,MDK,CEBPB,SOCS1,ITGB7,BCL11A,IRF1,CCL2,BCL2,FGR, ATRA+ATORVASTATIN 8 and Function 56.0 1.43E-17 1.14E-03 MYB,CEBPE,ID1,NP,THBD PIK3CG,BCL2A1,CD93,LY6E,CCR1,PTGES,CD38,CDKN2D,MYC,TREM1, Immune and BCL6,PRAM- Lymphatic 1,ANXA1,CALR,JUND,PLAU,PSMB9,ITGB7,TERT,IRF1,KLF2, System FGR,CD300A,CTSG,ID1,SELPLG,CCL4,CSF1R,ITGAM,SPI1,ID2,IL8, PECAM1,ITGAX,PRG2 (includes Development EG:5553),CD79A,ELF4,SLA,NFE2,ABCA1, ATRA+ATORVASTATIN 24 and Function 62.9 1.17E-19 3.25E-04 MDK,TNFRSF14,CEBPB Immune and SERPINA1,CD48,PIK3CG,BCL2A1,S100A9,CYBB,TXNIP,NOTCH1,LY6E, Lymphatic CDKN1A,CCR1,PTGES,CCL20,CD38,PTPN6,INPP5D,CDKN2D,NFKBIA, System MYC,TREM1,CARM1,BCL6,ANXA1,JUND,MYD88,SPP1,FYN,ITGB7,TER T, Development APAF1,IMPDH2,GAB2,C3,MPO,FGR,CD300A,IL1B,CSF1R,PROS1,SPI1, ATRA+ATORVASTATIN 48 and Function 139.6 9.37E-43 3.29E-06 SATB1,PTPRC,IL18RAP,IL8,N Cellular PLAU,ALOX5AP,MMP9,MDK,CCR1,NCF1,SOCS1,ID2,ITGB7,CD38,CCL2, ATRA 8 Movement 37.2 6.35E-12 1.77E-03 MYC,OSM,KCNH2,BCL2,FGR,PLCB2,CEBPE,ID1,TNFAIP8 PLAU,ALOX5AP,MDK,CCR1,NCF1,ID2,PTGES,ITGB7,CD38,CCL2,DEFA Cellular 1 ATRA 24 Movement 40.9 4.78E-13 6.45E-03 (includes EG:1667),FGR,TGM2,CTSG,PLCB2,VIM,CEBPE,IGFBP4 CXCR4,PIK3CG,S100A9,CCR1,CDKN1A,PTGES,ADORA3,CD38,IGFBP2, INPP5D,MYC,CAPN2,CCRL2,LAMB3,VIM,PARP9,IGFBP4,TNFRSF1B, PLAU,PTAFR,SPP1,LCP2,FYN,ITGB7,RNASE2,RAP2A,GAB2,MPO,FGR, CTSG,SELPLG,RGS3,ITGAM,SPI1,NCF1,ID2,CTSS,ITGAX,EGR1,ETV6, GDF15,ALOX5AP,ZFHX1B,CCND1,MDK,TNFRSF14,CHST4,ANXA2, Cellular ECGF1,CCL2,SIRPA,BCL2,DEFA1 (includes EG:1667),TGM2,PLCB2, ATRA 48 Movement 82.6 1.35E-25 6.16E-05 CEBPE Cellular ATORVASTATIN 8 Movement 0.0 1.00E+00 1.00E+00 NA Cellular ATORVASTATIN 24 Movement 24.5 4.19E-08 2.01E-02 CCL3L1,PLAU,ANXA1,IL8 Cellular FCER1G,NFKBIA,ADM,S100A4,DPYSL2,MMP9,S100A10,CDKN1A,EGR1, ATORVASTATIN 48 Movement 30.5 6.52E-10 2.89E-03 ANXA2,ANXA1 Cellular PLAU,ALOX5AP,MDK,CCR1,NCF1,SOCS1,ID2,ITGB7,IL8,CD38,CCL2, ATRA+ATORVASTATIN 8 Movement 33.3 9.21E-11 1.10E-03 MYC,BCL2,FGR,PLCB2,ID1,CEBPE,TNFAIP8 CCL4,CD97,PIK3CG,CSF1R,ITGAM,B4GALT5,SPI1,CCR1,NCF1,ID2, PTGES,IL8,CD38,MYC,WARS,ITGAX,PECAM1,IGFBP4,ANXA1,CALR, PLAU,PTAFR,S100A4,ALOX5AP,TNFRSF14,MDK,ITGB7,FCER1G,CCL2, Cellular SLC3A2,KCNH2,BCL2,DEFA1 (includes EG:1667),FGR,CTSL,TGM2, ATRA+ATORVASTATIN 24 Movement 68.7 2.03E-21 3.15E-04 CTSG,PLCB2,CEBPE,ID1,SELPLG SERPINA1,MYH10,CD97,PIK3CG,S100A9,NFKBIZ,S100A10,CDKN1A, CCR1,PTGES,CCL20,CD38,PTPN6,INPP5D,NFKBIA,MYC,SDCBP,LAMB 3, TNFAIP8,PAK1,ANXA1,MYD88,SPP1,CCL23,FYN,ITGB7,RNASE2, Cellular SLC3A2,GAB2,C3,MPO,NME1,FGR,IL1B,CSF1R,SPI1,ODC1,IL8,NPM1, ATRA+ATORVASTATIN 48 Movement 130.7 4.54E-40 3.29E-06 CCL3L1,FPRL1,ETV6,CCND1,DPYSL2 Cellular BCL2A1,RARRES3,CCR1,NCF1,ID2,CD38,TNFRSF10B,SMOX,CDKN2D, Growth and MYC,OSM,TNFAIP8,INHBB,IFI30,PLAU,NFE2,MMP9,CEBPB,MDK, ATRA 8 Proliferation 45.5 1.98E-14 1.77E-03 SOCS1,CCL2,IRF1,RTN4R,BCL2,MYB,ID1,CEBPE,THBD,NP Cellular BCL2A1,PLAU,NFE2,RARRES3,MDK,CEBPB,CCR1,NCF1,ID2,PTGES, Growth and TERT,CD38,SMOX,IRF1,CCL2,CDKN2D,DEFA1 (includes EG:1667), ATRA 24 Proliferation 33.0 1.14E-10 5.76E-03 PRG2 (includes EG:5553),TGM2,VIM,CEBPE,IGFBP4,CTSD,THBD IFITM1,CXCR4,PIK3CG,S100A9,BCL2A1,MT2A,LY6E,NOTCH1,CCR1, Cellular CDKN1A,DUSP5,PTGES,ADORA3,BPI,CD38,SMOX,IGFBP2,INPP5D, ATRA 48 Growth and 74.1 4.87E-23 1.20E-04 CDKN2D,PKN1,MYC,FOXC1,CAPN2,VIM,IGFBP4,INHBB,TNFRSF1B, Proliferation ZFP36L1,PLAU,SPP1,LCP2,CITED1,FYN,PTGS1,TERT,IFIH1,IRF1,GAB2, AIF1,IVNS1ABP,FABP6,ITGAM,TRIM22,SPI1,RARRES3,IFIT3,NCF1,ID2, OAS3,IL18RAP,ITGAX,PRG2 (includes EG:5553),XBP1,EGR1,CASP9, CTSD,ETV6,GDF15,MT1X,PTPN22,CCND1,CEBPB,MDK,TNFRSF14, ANXA2,GGT1,MAD1L1,CCL2,SIRPA,BCL2,DEFA1 (includes EG:1667), HK1,TGM2,MYB,ISG20,CEBPE,WT1,THBD Cellular Growth and ATORVASTATIN 8 Proliferation 0.0 1.00E+00 1.00E+00 NA Cellular Growth and ATORVASTATIN 24 Proliferation 30.9 4.93E-10 4.21E-02 JUND,CCL3L1,PLAU,KLF2,ANXA1,THBD,EMP3,IL8 Cellular Growth and JUND,TXNIP,S100A4,MMP9,S100A10,CDKN1A,ANXA2,EMP3,FCER1G, ATORVASTATIN 48 Proliferation 33.6 7.61E-11 3.29E-03 NFKBIA,ADM,S100A6,EGR1,THBD,ANXA1 Cellular BCL2A1,RARRES3,NCF1,CCR1,ID2,IL8,CD38,SMOX,CDKN2D,MYC, Growth and TNFAIP8,INHBB,CASP9,IFI30,PLAU,NFE2,CEBPB,MDK,SOCS1,CCL2, ATRA+ATORVASTATIN 8 Proliferation 40.8 5.32E-13 1.20E-03 IRF1,RTN4R,BCL2,MYB,ID1,CEBPE,NP,THBD PIK3CG,BCL2A1,LY6E,CCR1,DUSP5,PTGES,CD38,SMOX,CDKN2D, Cellular PKN1,MYC,FOXC1,WARS,IGFBP4,BCL6,INHBB,ANXA1,CALR,NCOA3, JUND,PLAU,CITED1,PTGS1,TERT,SLC22A18,IRF1,SLC7A5,SLC3A2, Growth and KLF2,PLAC8,S100A6,ID1,SCAP2,CCL4,CSF1R,ITGAM,SPI1,RARRES3, ATRA+ATORVASTATIN 24 Proliferation 64.4 3.98E-20 2.51E-04 NCF1,ID2,OAS3,IL8,FKBP4,PECAM1,IT OPTN,SERPINA1,CD48,PIK3CG,BCL2A1,S100A9,CYBB,TXNIP,NOTCH1, Cellular LY6E,BTG2,CDCA7L,HOXD13,CCR1,CDKN1A,PTGES,CCL20,CD38, PTPN6,SMOX,INPP5D,CDKN2D,NFKBIA,PKN1,MYC,FOXC1,BCL6, Growth and TNFAIP8,INHBB,ANXA1,JUND,NCOA3,MYD88,SPP1,GGTLA1,CCL23, ATRA+ATORVASTATIN 48 Proliferation 110.0 7.68E-34 1.95E-06 FYN,PTGS1,PRMT5,CSE1L,TERT,IFIH1,SLC7 BCL2A1,RARRES3,CCR1,NCF1,ID2,CD38,TNFRSF10B,SMOX,CDKN2D, MYC,OSM,TNFAIP8,DDIT4,PLAU,NFE2,MMP9,MDK,CEBPB,SOCS1, ATRA 8 Cell Death 30.6 6.25E-10 1.68E-03 CCL2,IRF1,BCL2,FGR,MYB,ID1,THBD,NP ELF4,PLAU,BCL2A1,NFE2,CEBPB,MDK,RARRES3,NCF1,CCR1,ID2, CD38,TERT,SMOX,IRF1,CCL2,CDKN2D,PRG2 (includes EG:5553), ATRA 24 Cell Death 18.0 3.77E-06 5.81E-03 FGR,CD300A,TGM2,IGFBP4,THBD,CTSD CXCR4,PIK3CG,BCL2A1,S100A9,MT2A,NOTCH1,UBE1L,CCR1,PTPRN2, CDKN1A,DUSP5,BPI,CD38,INPP5D,SMOX,CDKN2D,BAK1,MYC,CYBA, IGFBP4,TNFRSF1B,PLAU,PTAFR,SPP1,PPP1R16B,FYN,PTGS1,TERT, RNASE2,ADORA2A,IFIH1,IRF1,GAB2,MPO,CD300A,FGR,IVNS1ABP, RGS3,ITGAM,SATB1,SPI1,RARRES3,NCF1,ID2,OAS3,CTSS, PRG2 (includes EG:5553),XBP1,EGR1,CTSD,CASP9,ETV6,ELF4, GDF15,MT1X,PTPN22,CCND1,TNFRSF14,MDK,CEBPB,ECGF1, ATRA 48 Cell Death 76.4 1.01E-23 9.85E-05 MAD1L1,GGT1,CCL2,SIRPA,TYROBP,BCL2,TGM2,MYB,WT1,THBD ATORVASTATIN 8 Cell Death 7.2 6.59E-03 6.59E-03 TSC22D3 ATORVASTATIN 24 Cell Death 25.4 2.33E-08 4.50E-02 JUND,PLAU,KLF2,TSC22D3,EMP3,THBD,IL8,ANXA1 JUND,TFRC,TXNIP,S100A4,MMP9,S100A10,CDKN1A,CYP1B1,EMP3, ATORVASTATIN 48 Cell Death 37.5 5.02E-12 3.29E-03 FCER1G,ADM,NFKBIA,EGR1,THBD,ANXA1 BCL2A1,RARRES3,CCR1,NCF1,ID2,IL8,CD38,SMOX,CDKN2D,MYC, TNFAIP8,DDIT4,CASP9,PLAU,NFE2,MDK,CEBPB,SOCS1,CCL2,IRF1, ATRA+ATORVASTATIN 8 Cell Death 32.0 2.28E-10 1.54E-03 BCL2,FGR,MYB,ID1,THBD,NP PIK3CG,BCL2A1,CCR1,DUSP5,CD38,SMOX,CDKN2D,MYC,BCL6, IGFBP4,ANXA1,CALR,JUND,NCOA3,ITPR2,PLAU,PTAFR,PPP1R16B, PTGS1,TERT,IRF1,KLF2,PLAC8,CD300A,FGR,TSC22D3,ID1,CCL4, CSF1R,ITGAM,B4GALT5,SPI1,NCF1,ID2,OAS3,IL8,PECAM1, ATRA+ATORVASTATIN 24 Cell Death 56.0 1.40E-17 3.29E-04 PRG2 (includes EG:5553),NCF2,CASP9,CTSD,NFE2 CD48,PIK3CG,BCL2A1,S100A9,NFKBIZ,CYBB,NOTCH1,TXNIP,BTG2, S100A10,CCR1,PTPRN2,CDKN1A,CD38,PTPN6,INPP5D,SMOX,NFKBIA, CDKN2D,BAK1,MYC,BCL6,TNFAIP8,PAK1,UNG,ANXA1,JUND,ITPR2, NCOA3,MYD88,PPP1R16B,SPP1,CARD12,PRDX5,FYN,PTGS1,CSE1L, ATRA+ATORVASTATIN 48 Cell Death 127.9 3.11E-39 2.51E-06 TERT,RNASE2,IFIH1,APAF1,GNL3,GAB Inflammatory TNFRSF10B,CCL2,PLAU,OSM,BCL2,ALOX5AP,MMP9,CEBPB,NCF1, ATRA 8 Disease 27.1 6.99E-09 4.47E-04 CCR1,SOCS1,THBD Inflammatory CCL2,PLAU,ALOX5AP,PADI4,PRG2 (includes EG:5553),CEBPB,NCF1, ATRA 24 Disease 27.1 6.76E-09 3.44E-03 CTSG,CCR1,TGM2,THBD,CTSD CXCR4,CCR1,CDKN1A,NCF1,CTSS,ADORA3,INPP5D,BAK1, PRG2 (includes EG:5553),CTSD,TNFRSF1B,PLAU,PTAFR,SPP1,LCP2, Inflammatory ALOX5AP,PADI4,FYN,IL18R1,PTGS1,CEBPB,ADORA2A,CCL2,SIRPA, ATRA 48 Disease 60.1 8.20E-19 1.15E-04 ISGF3G,TYROBP,BCL2,HLA-B,TGM2,CTSG,SELPLG,THBD Inflammatory ATORVASTATIN 8 Disease NA NA NA NA Inflammatory ATORVASTATIN 24 Disease NA NA NA NA Inflammatory ATORVASTATIN 48 Disease NA NA NA NA Inflammatory ATRA+ATORVASTATIN 8 Disease 20.8 5.46E-07 1.49E-03 CCL2,PLAU,BCL2,ALOX5AP,CEBPB,NCF1,CCR1,SOCS1,THBD,IL8 CCL4,CCR1,NCF1,IL8,PECAM1,PRG2 (includes EG:5553),BCL6,CTSD, Inflammatory PLAU,PTAFR,ALOX5AP,ABCA1,TUBA3,PADI4,PTGS1,CEBPB,FCER1G, ATRA+ATORVASTATIN 24 Disease 49.6 1.21E-15 2.95E-04 CCL2,TYROBP,BCL2,HLA-B,CTSG,TGM2,SELPLG,THBD SERPINA1,CXCR4,NFKBIZ,CYBB,LYN,CD22,CDKN1A,CCR1,ADORA3, INPP5D,NFKBIA,BAK1,CEBPD,TNFSF13B,BCL6,TNFRSF1B,MYD88, PLAU,CXCL10,PTAFR,SPP1,LCP2,TUBA3,TAP1,PADI4,PPAT,GGTLA1, Inflammatory FYN,IL18R1,PTGS1,CCL3,ADORA2A,MGAM,IMPDH2,C3,HLA-B,CTSG, ATRA+ATORVASTATIN 48 Disease 122.6 1.23E-37 3.20E-06 SELPLG,IL1B,CCL4,PTPRC,ADORA2B,NC Cell-To-Cell BCL2A1,PLAU,NINJ2,CD93,NFE2,MMP9,CEBPB,MDK,CCR1,SOCS1, Signaling and ITGB7,GP1BB,CD38,TNFRSF10B,CCL2,MYC,OSM,BCL2,FGR,CEBPE, ATRA 8 Interaction 27.5 5.33E-09 1.77E-03 ID1,INHBB,THBD,NINJ1 Cell-To-Cell BCL2A1,PLAU,NINJ2,CD93,PSMB9,NFE2,DEFA3,CEBPB,MDK,CCR1, Signaling and PTGES,ITGB7,TERT,CD38,CCL2,PRG2 (includes EG:5553),FGR,TGM2, ATRA 24 Interaction 36.9 8.05E-12 5.76E-03 CTSG,VIM,CEBPE,THBD,NINJ1 CXCR4,S100A9,BCL2A1,CD93,GRASP,CCR1,CDKN1A,PTGES,BPI,CD38 , IGFBP2,INPP5D,MYC,VIM,INHBB,TNFRSF1B,PLAU,NINJ2,SPP1,PSMB9, Cell-To-Cell LCP2,DEFA3,FYN,IL18R1,ITGB7,TERT,GAB2,MPO,FGR,CTSG,SELPLG, RGS3,ITGAM,SPI1,IL18RAP,ITGAX,PRG2 (includes EG:5553),EGR1, Signaling and CCND1,CEBPB,CHST4,ANXA2,GGT1,CCL2,SIRPA,TYROBP,BCL2, ATRA 48 Interaction 54.2 4.70E-17 7.57E-05 TGM2,CEBPE,NINJ1,THBD Cell-To-Cell Signaling and ATORVASTATIN 8 Interaction 0.0 1.00E+00 1.00E+00 NA Cell-To-Cell Signaling and ATORVASTATIN 24 Interaction 32.6 1.54E-10 1.51E-02 CCL3L1,PLAU,KLF2,THBD,ANXA1,IL8 Cell-To-Cell Signaling and TFRC,IL32,TXNIP,S100A4,ABCA1,DPYSL2,MMP9,S100A10,CDKN1A, ATORVASTATIN 48 Interaction 25.3 2.38E-08 2.75E-03 ANXA2,FCER1G,ADM,EGR1,THBD,ANXA1 Cell-To-Cell Signaling and ATRA+ATORVASTATIN 8 Interaction NA NA NA NA Cell-To-Cell Signaling and ATRA+ATORVASTATIN 24 Interaction NA NA NA NA Cell-To-Cell Signaling and ATRA+ATORVASTATIN 48 Interaction NA NA NA NA BCL2A1,RARRES3,ID2,GP1BB,CD38,TNFRSF10B,SMOX,CDKN2D,MYC, OSM,DDIT4,TNFAIP8,PLAU,NFE2,CD52,MMP9,MDK,CEBPB,SOCS1, ATRA 8 Cancer 35.1 2.75E-11 1.77E-03 ITGB7,BCL11A,CCL2,IRF1,KCNH2,BCL2,FGR,MYB,CEBPE,ID1,NP,THBD BCL2A1,RARRES3,ID2,PTGES,CD38,SMOX,CDKN2D,ASB2,VIM,IGFBP4 , CTSD,ELF4,PLAU,PSMB9,CD52,NFE2,MDK,CEBPB,ITGB7,BCL11A,TER T, ATRA 24 Cancer 22.3 1.99E-07 6.45E-03 IRF1,CCL2,FGR,TGM2,CTSG,CEBPE,THBD CXCR4,PIK3CG,BCL2A1,MT2A,UBE1L,NOTCH1,PTPRN2,CDKN1A, DUSP5,PTGES,ADORA3,CD38,SMOX,IGFBP2,INPP5D,CDKN2D,MYC, BAK1,FOXC1,LAMB3,VIM,IGFBP4,TNFRSF1B,PLAU,PTAFR,PPP1R16B, SPP1,PSMB9,CD52,CITED1,FYN,PTGS1,ITGB7,TERT,ADORA2A,IRF1, GAB2,FGR,HLA- B,CTSG,SELPLG,RGS3,ITGAM,TRIM22,SPI1,RARRES3,ID2,OAS3, ITGAX,EGR1,ETV6,CASP9,CTSD,GDF15,MT1X,PTPN22,CCND1, TNFRSF14,MDK,CEBPB,ANXA2,ECGF1,BCL11A,GGT1,MAD1L1, ATRA 48 Cancer 50.4 6.64E-16 1.20E-04 CCL2,SIRPA,TYROBP,BCL2,TGM2,MYB,CEBPE,WT1,THBD ATORVASTATIN 8 Cancer 0.0 1.00E+00 1.00E+00 NA ATORVASTATIN 24 Cancer 23.7 7.48E-08 3.66E-02 JUND,PLAU,KLF2,TUBA3,ANXA1,THBD,IL8 JUND,TFRC,TXNIP,TUBA3,S100A4,MMP9,DPYSL2,S100A10,CDKN1A, ATORVASTATIN 48 Cancer 28.6 2.53E-09 3.29E-03 ANXA2,CYP1B1,FCER1G,NFKBIA,ADM,EGR1,ANXA1,THBD BCL2A1,RARRES3,ID2,GP1BB,IL8,CD38,SMOX,CDKN2D,MYC,DDIT4, TNFAIP8,CASP9,PLAU,NFE2,CD52,MDK,CEBPB,SOCS1,ITGB7, ATRA+ATORVASTATIN 8 Cancer 29.8 1.09E-09 1.49E-03 BCL11A,IRF1,CCL2,BCL2,FGR,MYB,CEBPE,ID1,NP,THBD CD97,PIK3CG,BCL2A1,DUSP5,PTGES,CD38,SMOX,CDKN2D,MYC, FOXC1,BCL6,IGFBP4,ANXA1,CALR,JUND,NCOA3,PLAU,PTAFR, PPP1R16B,PSMB9,TUBA3,CD52,CITED1,PTGS1,ITGB7,TERT, SLC22A18,PSCD1,IRF1,SLC3A2,KLF2,FGR,HLA-B,CTSG,ID1, ATRA+ATORVASTATIN 24 Cancer 45.3 2.36E-14 3.15E-04 SELPLG,CCL4,CSF1R,ITGAM,B4GALT5,SPI1,RARRES3,ID2,OA SERPINA1,CD48,CD97,PIK3CG,BCL2A1,NOTCH1,TXNIP,BTG2, CDCA7L,S100A10,PTPRN2,CDKN1A,PTGES,CD38,PTPN6,SMOX, INPP5D,NFKBIA,CDKN2D,MYC,BAK1,FOXC1,SDCBP,LAMB3,BCL6, TNFAIP8,ANXA1,PAK1,RIT1,JUND,NCOA3,PPP1R16B,SPP1,FYN, ATRA+ATORVASTATIN 48 Cancer 84.5 3.69E-26 3.29E-06 PTGS1,ITGB7,TERT,PSCD1,APAF1,SLC3A2,IMPDH2,GAB2 BCL2A1,IDH1,FNDC3B,RARRES3,CCR1,NCF1,ID2,CD38,TNFRSF10B, CDKN2D,TGM3,MYC,OSM,CDC42EP4,INHBB,CD79A,PLAU,NFE2, Cellular MMP9,CEBPB,SOCS1,BCL11A,CCL2,IRF1,BCL2,OLIG1,FGR,MYB, ATRA 8 Development 48.8 2.10E-15 1.77E-03 CEBPE,ID1,NP PLAU,BCL2A1,NFE2,RARRES3,CEBPB,CCR1,NCF1,ID2,BCL11A,CD38, Cellular TERT,CCL2,IRF1,CDKN2D,TGM3,CDC42EP4,DEFA1 (includes EG:1667), ATRA 24 Development 22.9 1.29E-07 5.76E-03 FGR,CEBPE,CTSD,CD79A CXCR4,PIK3CG,BCL2A1,S100A9,NOTCH1,CDKN1A,CCR1,CD38, INPP5D,CDKN2D,MYC,FOXC1,CDC42EP4,INHBB,TNFRSF1B,PLAU, SPP1,LCP2,FYN,TERT,IRF1,RAP2A,GAB2,FGR,RGS3,ITGAM,SATB1, Cellular SPI1,RARRES3,NCF1,ID2,CD300LF,TGM3,XBP1,EGR1,ETV6,CD79A, ATRA 48 Development 49.4 1.39E-15 1.27E-04 CCND1,CEBPB,ANXA2,BCL11A,MAD1L1,TAPBP,CCL2,SIRPA, TYROBP,BCL2,DEFA1 (includes EG:1667),MYB,CEBPE,WT1 Cellular ATORVASTATIN 8 Development NA NA NA NA Cellular ATORVASTATIN 24 Development NA NA NA NA Cellular ATORVASTATIN 48 Development NA NA NA NA IDH1,RARRES3,NCF1,CCR1,ID2,IL8,CD38,CDKN2D,MYC,TGM3, Cellular CDC42EP4,INHBB,PLAU,NFE2,CEBPB,SOCS1,BCL11A,CCL2,IRF1, ATRA+ATORVASTATIN 8 Development 40.1 8.40E-13 1.54E-03 BCL2,OLIG1,FGR,MYB,ID1,CEBPE,NP CCL4,PIK3CG,BCL2A1,CSF1R,ITGAM,SPI1,RARRES3,CCR1,NCF1, ID2,CD38,IL8,CDKN2D,TGM3,MYC,FOXC1,PECAM1,CDC42EP4, TREM1,BCL6,INHBB,CD79A,CALR,PLAU,NFE2,S100A4,CEBPB, Cellular BCL11A,TERT,FCER1G,CCL2,IRF1,TYROBP,PLAC8,BCL2,OLIG1, ATRA+ATORVASTATIN 24 Development 47.6 4.64E-15 1.61E-04 DEFA1 (includes EG:1667),CTSL,BHLHB2,FGR,CEBPE PIK3CG,BCL2A1,S100A9,NOTCH1,BTG2,CDKN1A,CCR1,CD38, PTPN6,INPP5D,NFKBIA,CDKN2D,MYC,FOXC1,CDC42EP4,TREM1, OPRS1,BCL6,INHBB,PAK1,MYD88,SPP1,FYN,TERT,APAF1,C3,GAB2, Cellular OLIG1,NME1,FGR,IL1B,CSF1R,SPI1,SATB1,PTPRC,RARRES3,HES1, ATRA+ATORVASTATIN 48 Development 74.4 4.04E-23 3.29E-06 ODC1,IL8,NPM1,TGM3,XBP1,ETV6,CD79A,THRA,C Tissue ATRA 8 Development NA NA NA NA Tissue ATRA 24 Development NA NA NA NA Tissue ATRA 48 Development NA NA NA NA Tissue ATORVASTATIN 8 Development 0.0 1.00E+00 1.00E+00 NA Tissue ATORVASTATIN 24 Development 31.6 3.03E-10 1.51E-02 CCL3L1,PLAU,ANXA1,THBD,IL8 Tissue ATORVASTATIN 48 Development 16.3 1.27E-05 2.20E-03 FCER1G,NFKBIA,IL32,MMP9,CDKN1A,EGR1,ANXA1,THBD Tissue ATRA+ATORVASTATIN 8 Development 16.8 8.63E-06 1.14E-03 CCL2,PLAU,MYC,BCL2,CCR1,ITGB7,GP1BB,THBD,NINJ1,CD38,IL8 CCL4,CD97,ITGAM,CD93,SPI1,CCR1,PTGES,IL8,CD38,MYC,PECAM1, ITGAX,ANXA1,CALR,PLAU,NINJ2,PTAFR,CITED1,PTGS1,ITGB7,TERT, PSCD1,FCER1G,CCL2,SLC7A5,SLC3A2,TYROBP,BCL2,TGM2,CTSG,ID1 Tissue , ATRA+ATORVASTATIN 24 Development 45.1 2.65E-14 3.21E-04 SELPLG,THBD,NINJ1 CD48,CD97,CXCR4,S100A9,CYBB,LYN,CD93,GRASP,ATP1B1,CCR1, CDKN1A,CCL20,TNFAIP6,GP1BB,CAST (includes EG:831),CD38,INPP5D, MYC,TNFRSF1B,ANXA1,CXCL10,PLAU,NINJ2,PTAFR,SPP1,LGALS9, Tissue LCP2,CITED1,FYN,CCL3,ITGB7,TERT,ADORA2A,PSCD1,SLC7A5, ATRA+ATORVASTATIN 48 Development 73.2 8.98E-23 7.01E-07 SLC3A2,C3,GAB2,AMICA1,CTSG,SEL ATRA 8 Cell Signaling NA NA NA NA ATRA 24 Cell Signaling NA NA NA NA ATRA 48 Cell Signaling NA NA NA NA ATORVASTATIN 8 Cell Signaling NA NA NA NA ATORVASTATIN 24 Cell Signaling NA NA NA NA ATORVASTATIN 48 Cell Signaling NA NA NA NA PLAU,CEBPB,CCR1,NCF1,SOCS1,ITGB7,IL8,CD38,CCL2,IRF1,SUCNR1, ATRA+ATORVASTATIN 8 Cell Signaling 15.5 2.17E-05 6.39E-04 SQSTM1,BCL2,RGS16,FGR,ULK1,CD79A,THBD CCL4,PIK3CG,CSF1R,ITGAM,SPI1,PDE9A,LILRB2,CCR1,SH2D3C,CD38, IL8,SUCNR1,PKN1,PECAM1,TREM1,RGS16,IGFBP4,CD79A,ANXA1, LILRA5,CALR,ITPR2,PLAU,PTAFR,PTPN22,DEFA3,ITGB7,FCER1G, CCL2,SLC7A5,SQSTM1,SLC3A2,ACCN2,KLF2,TYROBP,S100A6,BCL2, ATRA+ATORVASTATIN 24 Cell Signaling 31.6 3.03E-10 3.11E-04 CYTL1,CD300A,FGR,SCAP2,THBD CD48,PIK3CG,S100A9,LY6E,GRASP,NOTCH1,CCR1,CCL20,CD38, PTPN6,ASS,INPP5D,NFKBIA,PKN1,BAK1,TREM1,OPRS1,PAK1, ANXA1,RIT1,ITPR2,MYD88,SPP1,CCL23,FYN,ITGB7,SLC7A5, SLC3A2,GAB2,C3,FGR,CD300A,SCAP2,IL1B,INPP1,CSF1R,SPI1, ATRA+ATORVASTATIN 48 Cell Signaling 72.2 1.82E-22 1.90E-06 PTPRC,ADORA2B,PKD2L1,PDE9A,IL18RAP,IL8,PRMT1,N Hematological ATRA 8 Disease NA NA NA NA Hematological ATRA 24 Disease NA NA NA NA Hematological ATRA 48 Disease NA NA NA NA Hematological ATORVASTATIN 8 Disease NA NA NA NA Hematological ATORVASTATIN 24 Disease NA NA NA NA Hematological ATORVASTATIN 48 Disease NA NA NA NA BCL2A1,PLAU,CD52,NFE2,CEBPB,SOCS1,ITGB7,GP1BB,IL8,CD38,MYC Hematological , ATRA+ATORVASTATIN 8 Disease 23.2 1.03E-07 1.46E-03 BCL2,FGR,MYB,DDIT4,CASP9,THBD,NP CCL4,PIK3CG,BCL2A1,CSF1R,ITGAM,SPI1,IL8,CD38,MYC,PECAM1, BCL6,ANXA1,CASP9,ITPR2,PLAU,ABCA1,NFE2,CD52,CEBPB,PTGS1, Hematological ITGB7,TERT,PSCD1,KLF2,TYROBP,KCNH2,BCL2,FGR,TGM2,SELPLG, ATRA+ATORVASTATIN 24 Disease 28.0 3.83E-09 3.11E-04 THBD CXCR4,PIK3CG,BCL2A1,S100A9,LYN,UBE1L,MCL1,NOTCH1,ATP1B1, CD22,CDKN1A,GP1BB,CAST (includes EG:831),CD38,PTPN6,INPP5D, NFKBIA,BAK1,MYC,CASP7,TRAF1, CEBPD,TNFSF13B,BCL6,ANXA1,TNFRSF1B,ITPR2,CXCL10,PLAU, Hematological MYD88,LGALS9,SPP1,CD52,LCP2,PPAT,FYN,CCL3,PTGS1,ITGB7,TERT ATRA+ATORVASTATIN 48 Disease 64.5 3.83E-20 3.24E-06 , Immunological ATRA 24 Disease NA NA NA NA Immunological ATRA 48 Disease NA NA NA NA Immunological ATORVASTATIN 8 Disease NA NA NA NA Immunological ATORVASTATIN 24 Disease NA NA NA NA Immunological ATORVASTATIN 48 Disease NA NA NA NA Immunological BCL2A1,NCF1,CCR1,SOCS1,ITGB7,IL8,IRF1,MYC,BCL2,MYB,ID1, ATRA+ATORVASTATIN 8 Disease 19.3 1.57E-06 1.46E-03 CEBPE,NP,CASP9 ATRA+ATORVASTATIN 24 Immunological 37.7 4.45E-12 3.11E-04 CCL4,PIK3CG,BCL2A1,CSF1R,ITGAM,NCF1,CCR1,IL8,MYC,PECAM1, Disease NCF2,IGFBP4,BCL6,CASP9,ANXA1,ITPR2,PTAFR,ABCA1,PTPN22, PADI4,PTGS1,ITGB7,TERT,FCER1G,IRF1,CCL2,KLF2,TYROBP,BCL2, TGM2,ID1,CEBPE,SELPLG CXCR4,CD48,PIK3CG,BCL2A1,LYN,CYBB,MCL1,BTG2,CD22,CCR1, CDKN1A,CAST (includes EG:831),INPP5D,NFKBIA,BAK1,MYC,CASP7, TRAF1,IGFBP4, TNFSF13B,TNFRSF1B,ANXA1,ITPR2,CXCL10,MYD88,PTAFR,LGALS9, Immunological SPP1,LCP2,TAP1,PADI4,PPAT,FYN,IL18R1,CCL3,PTGS1,ITGB7,TERT, ATRA+ATORVASTATIN 48 Disease 73.5 7.67E-23 3.24E-06 APAF1,IRF1,KLF Table 2: Networks generated using the set of differentially expressed genes found in the most enriched functional classes associated to the three treatments over the time course. Network Score Focus genes Hub genes (3 top ranked most connected genes) 1 57 35 IL1B; IRF1; ITGAM 2 57 35 MYC; BCL2; BCL2A1 3 57 35 CDKN1A; EGR1;MMP9; IL8 4 21 19 IGF1R; IL6; AKT1 5 20 18 LCP2; LYN; FYN 6 18 17 NKBIA; TERT; NCOA3 7 16 16 TNF 8 16 16 IFNG; IL2 9 16 16 IL4; IL13;1TGFB1 10 16 16 MAPK8 11 15 15 EGF; SP1 12 13 14 TP53; PTEN 13 8 10 CDKN2A; ERBB2; FN1 Differentially expressed hub genes are shown in bold. Table 3: Genes associated with apoptosis, selectively enhanced by the combination of ATRA plus atorvastatin1

Gene name Description CCL4 chemokine (C-C motif) ligand 4 IL1B interleukin 1, beta CCL3 chemokine (C-C motif) ligand 3 BTG2 BTG family, member 2 CARD12 caspase recruitment domain family, member 12 GHRL ghrelin/obestatin preprohormone BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) CD48 CD48 molecule MYD88 myeloid differentiation primary response gene (88) CD22 CD22 molecule PTPRC protein tyrosine phosphatase, receptor type, C CASP7 caspase 7, apoptosis-related cysteine peptidase PECAM1 platelet/endothelial cell adhesion molecule (CD31 antigen) KLF2 Kruppel-like factor 2 (lung) RHOC ras homolog gene family, member C CAST (includes calpastatin EG:831) TRAF1 TNF receptor-associated factor 1 PIM1 pim-1 oncogene PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta MTF1 metal-regulatory transcription factor 1 CSF1R colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog APAF1 apoptotic peptidase activating factor ICAM1 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ZFP36 zinc finger protein 36, C3H type, homolog (mouse) G6PD glucose-6-phosphate dehydrogenase LDLR low density lipoprotein receptor (familial hypercholesterolemia) BCL3 B-cell CLL/lymphoma 3 JAK2 Janus kinase 2 (a protein tyrosine kinase) GLIPR1 GLI pathogenesis-related 1 (glioma) SGK serum/glucocorticoid regulated kinase VCL vinculin PTPN6 protein tyrosine phosphatase, non-receptor type 6 LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog HOXC6 homeobox C6 ITPR2 inositol 1,4,5-triphosphate receptor, type 2 PRDX5 peroxiredoxin 5 PYCARD PYD and CARD domain containing 1For all genes in this table p<0.0002 Table 4: Genes associated with cell differentiation, selectively enhanced by the combination of ATRA plus atorvastatin 1 Gene name Description ACVR1 activin A receptor, type I JAK2 Janus kinase 2 (a protein tyrosine kinase) PTPRC protein tyrosine phosphatase, receptor type, C BCL3 B-cell CLL/lymphoma 3 BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) PECAM1 platelet/endothelial cell adhesion molecule (CD31 antigen) CSF1R colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog CAST (includes calpastatin EG:831) IL1B interleukin 1, beta BTG2 BTG family, member 2 PIM1 pim-1 oncogene TREM1 triggering receptor expressed on myeloid cells 1 APAF1 apoptotic peptidase activating factor OLIG1 oligodendrocyte transcription factor 1 LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog RGS2 regulator of G-protein signalling 2, 24kDa CCL3 chemokine (C-C motif) ligand 3 ZFP36 zinc finger protein 36, C3H type, homolog (mouse) ICAM1 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor GHRL ghrelin/obestatin preprohormone

1For all genes in this table p<0.0002