GAD1, Human Recombinant CPSQ1, GAD, SCP, Glutamate Decarboxylase 1 Catalog # Pbv11633r

10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

GAD1, human recombinant CPSQ1, GAD, SCP, Glutamate decarboxylase 1 Catalog # PBV11633r

Specification

GAD1, human recombinant - Background GAD1, human recombinant - Product info This gene encodes one of several forms of glutamic acid decarboxylase, identified as a Primary Accession Q99259 major autoantigen in insulin-dependent Calculated MW 69.3 kDa KDa diabetes. The enzyme encoded is responsible for catalyzing the production of GAD1, human recombinant - Additional Info gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has Gene ID 2571 been identified in the human pancreas since it Other Names has been identified as an autoantigen and an CPSQ1, GAD, SCP, Glutamate autoreactive T cell target in insulin-dependent decarboxylase 1 diabetes. This protein may also play a role in the stiff man syndrome. Deficiency in this Gene Source Human enzyme has been shown to lead to pyridoxine Source E.coli dependency with seizures. Recombinant Assay&Purity SDS-PAGE;> 80% human GAD1 protein, fused to His-tag at Recombinant Yes N-terminus, was expressed in E.coli. Sequence MGSSHHHHHH SSGLVPRGSH MGSMASSTPS SSATSSNAGA DPNTTNLRPT TYDTWCGVAH GCTRKLGLKI CGFLQRTNSL EEKSRLVSAF KERQSSKNLL SCENSDRDAR FRRTETDFSN LFARDLLPAK NGEEQTVQFL LEVVDILLNY VRKTFDRSTK VLDFHHPHQL LEGMEGFNLE LSDHPESLEQ ILVDCRDTLK YGVRTGHPRF FNQLSTGLDI IGLAGEWLTS TANTNMFTYE IAPVFVLMEQ ITLKKMREIV GWSSKDGDGI FSPGGAISNM YSIMAARYKY FPEVKTKGMA AVPKLVLFTS

Page 1/2 10320 Camino Santa Fe, Suite G San Diego, CA 92121 Tel: 858.875.1900 Fax: 858.622.0609

EQSHYSIKKA GAALGFGTDN VILIKCNERG KIIPADFEAK ILEAKQKGYV PFYVNATAGT TVYGAFDPIQ EIADICEKYN LWLHVDAAWG GGLLMSRKHR HKLNGIERAN SVTWNPHKMM GVLLQCSAIL VKEKGILQGC NQMCAGYLFQ PDKQYDVSYD TGDKAIQCGR HVDIFKFWLM WKAKGTVGFE NQINKCLELA EYLYAKIKNR EEFEMVFNGE PEHTNVCFWY IPQSLRGVPD SPQRREKLHK VAPKIKALMM ESGTTMVGYQ PQGDKANFFR MVISNPAATQ SDIDFLIEEI ERLGQDL Target/Specificity GAD1

Format Liquid

Storage -20°C;In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

GAD1, human recombinant - Protocols

Provided below are standard protocols that you may find useful for product applications.

• Western Blot • Blocking Peptides • Dot Blot • Immunohistochemistry • Immunofluorescence • Immunoprecipitation • Flow Cytomety • Cell Culture

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