Longevity Industry in LANDSCAPE OVERVIEW

SCIENCE, TECHNOLOGIES, COMPANIES, INVESTORS, TRENDS Longevity Industry in Israel Landscape Overview 2019

Mind Map Longevity Industry in Israel 3

Executive Summary 6

Chapter I: Israel Longevity Industry Landscape Overview 18

Сhapter II: History of Geroscience in Israel 37

Chapter III: Current State of Longevity in Israel 42

Chapter IV: Israeli Longevity Alliance (ISRLA)/VETEK 58

Chapter V: Top Universities Focusing on Longevity 61

Chapter VI: Media and Conferences 70

Chapter VII: The Policy Landscape of Longevity in Israel 76

Chapter VIII: Global Landscape Overviews from our previous reports 84

Chapter IX: The Economics of Longevity in Israel 109

APPENDIX/ PROFILES 10 Israel Longevity R&D Centers 128

10 Israel Longevity Non-Profit Organizations 141

10 Israel Longevity Conferences 154

60 Israel Longevity Influencers 167

160 Companies: Longevity in Israel 230

180 Investors: Longevity in Israel 393

Disclaimer 577 Longevity Industry in Israel 500+ Page Analytical Report 3

Aging Analytics Agency announces the publication of a new analytical report titled Longevity Industry in Israel. 500+ pages in length, the report aims to outline the history, present state and future of the Longevity Industry in Israel, profiling 160 companies, 180 investors, 10 Longevity non-profit organizations, 60 influencers, 10 university research labs and 10 conferences.

The report concludes that although Israel has made good first steps over the past five years toward prioritizing aging as part of its national agenda, it needs to take additional steps in order to realise that goal:

● Continuing to maintain and cultivate its existing strengths: government support of longevity industry development and a strong academic geroscience research landscape.

● Firming up its national development strategy and placing healthspan extension at its center, in the way that the UK has done by listing the problem of an Aging Population as the #2 grand challenge in its Industrial Strategy.

60 10 10 Influencers Research Labs & Hubs Conferences

160 180 10 Companies Investors Non-Profit Foundations

Longevity Industry in Israel 500+ Page Analytical Report 4

Regional Longevity Industry Case Studies

It is part of a series of regional case studies on the longevity industry globally, defined as a synergy between geroscience, advanced biomedicine, P3 (precision preventive personalised) medicine, the AgeTech market, and finance. These regional studies follow up on the content of two previous 'Longevity Industry Landscape Overview' reports: Volume I “The Science of Longevity” (750 pages), and Volume II “The Business of Longevity” (650 pages), published earlier last year.

These ongoing analytical reports are part of a collaborative project by The Global Longevity Consortium, consisting of the Biogerontology Research Foundation, Deep Knowledge Analytics, Aging Analytics Agency and the Longevity.International platform. The report seeks to document what makes Israel fertile ground for a global Longevity industry hub, and how that ground could be developed.

Why Israel?

Israel is a unique country with close academic and industrial ties to the United State and , and consequently Israel's geroscience has matured at a pace that outstrips the rest of the geographical region (with at least one ageing research center or cluster either present or planned for every Israeli university).

It is also an attractive technology and innovation hub: The amount of funding being raised by high-tech startups in Israel continues to grow, reaching $6.47 bln in 2018 through 623 deals. Large IT and tech giants have also been opening locations in Israel. Google for instance set up an R&D center in Israel in 2016, where many of the company's most important products (including Google Suggest, Google Trends, and Google Live Results) were developed. Moreover this report comes after the creation of BIRAX Aging, announced by The Britain Israel Research and Academic Exchange Partnership (BIRAX, a group consisting of over 1000 scientists from 120 institutions, including four Nobel Prize winners and three members of the UK House of Lords), in June 2018. Longevity Companies - 160 Industry in Israel Personalized Investors - 180 Medicine Non-Profits - 10 Landscape 2019 R&D Centers - 10

Progressive Wellness Investors

Companies

Non-Profits R&D Centers

Preventive Medicine

AgeTech LONGEVITY Regenerative INTERNATIONAL Medicine Longevity Industry in Israel 2019 - 160 COMPANIES

Drug Development Progressive wellness Gene therapies AgeTech

Neurotech Others Progressive R&D Implant & Prosthetics Cell therapy

Diagnostic 60 Israeli Influencers in Longevity 7

Aaron Alex Friedman Anat Ben-Zvi Assaf Sella Benjamin Boaz Misholi Dan Peer Doron Garfinkel Doron Melamed Dov Dov Shmotkin Ehud Cohen Ciechanover Sredni Chernichovsky

Eitan Okun Eldad Tzahor Eli Mizrahi Eyal Banin Gabriel Barbash Gil Atzmon Hadas Lewy Haim Cohen Hanan Tal Howard Litwin Idan Papier Idan Segev

Ilia Stambler Israel Doron Itamar Harel Itamar Raz Joe van Zwaren Jonathan Michal Neeman Michal Mooly Eden Natalie Yivgi Ohana Nir Barzilai Nirit Lev Mandelbaum-Shor Schwartz

Rafi Eitan Ran Balicer Raphael Ruth Arnon Sami Sagol Sara Carmel Shai Brill Shai Efrati Shai Shen-Orr Sivan Sol Efroni Tal Dvir Gorodetsky Henis-Korenblit

Tzvi Dwolatzky Uri Alon Valery Yael Benvenisti Yakir Kaufman Yaky Yanay Yechezkel Yitzhak Brick Yosef Yossi Heymann Zorian Zvi Lanir Krizhanovsky Barenholz Gruenbaum Radomyslsky 60 Longevity Influencers 8

Aaron Alex Anat Assaf Sella Benjamin Boaz Dan Peer Ciechanover Friedman Ben-Zvi Sredni Misholi

Doron Doron Dov Dov Ehud Eitan Okun Eldad Garfinkel Melamed Chernichovsky Shmotkin Cohen Tzahor

Eli Mizrahi Eyal Banin Gabriel Gil Atzmon Hadas Haim Hanan Tal Barbash Lewy Cohen

Howard Idan Idan Segev Ilia Israel Itamar Itamar Raz Litwin Papier Stambler Doron Harel 60 Longevity Influencers 9

Joe van Jonathan Michal Michal Mooly Natalie Nir Barzilai Nirit Lev Zwaren Mandelbaum- Neeman Schwartz Eden Yivgi Shor Ohana

Rafi Eitan Ran Balicer Raphael Ruth Arnon Sami Sagol Sara Shai Brill Shai Efrati Gorodetsky Carmel

Shai Sivan Sol Efroni Tal Dvir Tzvi Uri Alon Valery Yael Shen-Orr Henis-Korenblit Dwolatzky Krizhanovsky Benvenisti

Yakir Yaky Yanay Yechezkel Yitzhak Yosef Yossi Zorian Zvi Lanir Kaufman Barenholz Brick Gruenbaum Heymann Radomyslsky 7 Israeli Universities with Longevity Labs / Departments 10

1. Ben Gurion University of 5. University of the Negev

6. The Hebrew University 2. Bar Ilan University of Jerusalem

7. Technion - Israel 3. University Institute of Technology

4. Weizmann Institute of Science 10 Longevity Non-profits 11

6. Israeli Foundation for 1. Disabled, Osteoporosis and Bone Not Half a Person Diseases

2. Eshel: Planning and 7. Israeli Longevity Development of Services Alliance (ISRLA – ILA for the Aging Israel)

8. Melabev - Caring for 3. Israel Association for people with dementia and Geriatric Medicine their families

9. The Taub Center for 4. Israel Cancer Social Policy Studies in Association Israel

5. Israel 10. Vetek (Seniority) - the Gerontological Movement for Longevity Society and Quality of Life 10 Longevity R&D Centers 12

6. Sagol Longevity 1. Center for Digital Research Institute - Innovation Weizmann Institute of Science

7. The Center for 2. Rambam Center for Multidisciplinary Research Healthy Aging in Aging - BGU

3. International Longevity 8. The Center for Research Center Israel and Study of Aging - TAU

4. Bar Ilan University aging 9. The Herczeg Institute on research cluster Aging - TAU

5.Myers-JDC-Brookdale 10. The Israel Institute - The Center for Gerontological Data Center Research on Aging (IGDC) - HUJI 10 Longevity Conferences 2017-2018 13 Executive Summary 14

BIRAX Aging: Leapfrogging Population Ageing & Establishing A Strong Longevity Industry & R&D Landscape

One of the most significant developments to occur in the Israel Longevity Industry in the past year is the formation of the BIRAX Partnership on Aging.

The Britain Israel Research and Academic Exchange Partnership (BIRAX) is a multi-million pound initiative launched by the British Council, the Pears Foundation and the British Embassy in Israel, supported by both the Israeli and British Ministries of Science, to invest in research initiatives jointly undertaken by scientists in Britain and Israel.

In June 2018, BIRAX announced the launch of BIRAX Aging, which seeks to "advance innovative scientific research into ageing and its impact on human health and to encourage the use of cutting edge technology, big data and personalised medicine in aging research" and "develop meaningful, sustainable and mutually enriching scientific collaboration between researchers, labs and institutions." This follows in the steps of the previous BIRAX Regenerative Medicine Initiative that has thus far committed roughly £8 million to 19 projects spearheaded by over 100 researchers to develop new stem cell and regenerative medicine therapies. £5 million has been committed to BIRAX Aging, and some of its initial disease targets include Parkinson’s, Alzheimer’s, heart disease, multiple sclerosis and diabetes, multimorbidity and frailty.

BIRAX announced its first call for research proposals in April 2018, focusing on two broad themes:

A. Research into the impact of aging processes on human health and B. Using precision medicine and big data to identify innovative biomarkers, algorithms and computational techniques to help prevent the harmful effects associated with ageing. Executive Summary 15

Prioritizing Aging As a Core Aspect of Israel’s National Development Strategy & Agenda

An increasing number of progressive governments are releasing policies and initiatives that recognize demographic aging as a pressing modern socioeconomic concern. Among these is the UK Government's £300 million commitment to develop solutions for demographic aging and bridging its aging science sphere with the longevity business and investment landscape.

UK’s initiative includes £98 million earmarked for a "healthy aging program" aiming to develop new products and services to help the elderly live in their homes for longer, combat loneliness and increase overall independence and wellbeing, while £210 million is being allocated to a "data to early diagnosis and precision medicine” program to improve both diagnosis and treatment of age-related diseases.

But BIRAX Aging may be the first government initiative that explicitly aims to directly treat aging, including targeting the underlying cause of age-related diseases. As such, it demonstrates that both British and Israeli governments have taken a progressive stance in response to the socioeconomic challenges posed by demographic aging.

The group consists of over 1,000 scientists from 120 institutions, including four Nobel Prize winners and three members of the UK House of Lords.

In addition to BIRAX's founding partners, BIRAX Aging is also supported by a host of other prominent UK foundations and charities, including the British Heart Foundation, JDRF, Parkinson’s UK, MS Society and Alzheimer’s Society, Weizmann UK, Clore Foundation, the Wolfson Foundation and the Ministry of Science, Technology and Space in Israel, Diabetes UK, Arthritis Research UK, Dementia Discovery Fund, the Rosetrees Trust, Brightfocus Foundation and Dunhill Medical Trust.

One of the first tangible successes of BIRAX Aging was a four-day conference in September 2018 that brought together 80 leading Israeli scientists with British peers to discuss the problem of demographic aging, and its possible solutions. The conference was held at King’s College London, and featured representatives of the British Embassy in Tel Aviv, Lord Winston, and senior dons from Oxford and Cambridge. Executive Summary 16

Israel Can Become an International Longevity Hub Through Continued Government Commitment

Due to its emerging Longevity Industry and remarkably mature geroscience landscape, Israel has excellent potential to become a notable force on the international Longevity scene. Although the past five years have witness excellent progress, additional steps are required to realize Israel’s full potential. Specifically, the country needs to further maintain and cultivate its existing strengths, including:

● Government Support of Longevity Research & Development: The Israeli government has made an excellent first step toward cementing Longevity as a core priority, but it needs to further strengthen its Longevity agenda and position healthspan extension as the center of a major national development plan, akin to UK’s successful decision to list the problem of an Aging Population as the #2 grand challenge in its industrial strategy. It needs to commit more government funding for basic aging research and the development of therapies to extend healthspan..

● Highly Mature Academic Geroscience Landscape: For a number of years, Israel has outputted high-volume, high-quality research into the fundamental biology of aging and potential healthspan extension interventions. Most compellingly, 100% of Israeli universities have now established dedicated facilities for aging research, including several labs and interdisciplinary centers.

● Attractive Technology and Innovation Hub: The amount of funding raised by high-tech startups in Israel continues to grow, reaching $6.47 bln in 2018 through 623 deals. Israeli startups are also acquired much faster than their foreign counterparts. On average, Israeli startups are acquired four years after founding, compared to an average of six years in Europe. This accelerated return on investment makes the tech industry in Israel very attractive for international investors. We are also seeing large IT and tech giants opening locations in Israel. For example, in 2016 Google established an R&D center in Israel, where many of the company's most important products (including Google Suggest, Google Trends, and Google Live Results) were developed. Google was not the first US company to invest in Israel’s potentials; Intel, for instance, set up its first international R&D lab in Israel in 1974 after recognizing the country’s strengths in technology innovation.