Sports Related Neuromuscular Disorders
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Median Nerve Compression at Pronator Teres
1 Median Nerve Compression at Pronator Teres Surgical Indications and Considerations Anatomical Considerations: The median nerve and brachial artery travel together down the arm. Therefore, one must be very careful not to interfere with either the median nerve or the brachial artery, especially when conducting surgical procedures. In the area of the pronator teres, there are many tendons as well. It is important to identify, as much as possible, the correct site of compression. Pathogenesis: The median nerve can get entrapped or compressed by several structures in the arm. The pronator teres muscle is the most common. Others entrapment sites include the flexor digitorum superficialis arch, the lacertus fibrosis (bicipital aponeurosis), and ligament of Struthers (frequency occurs in that order). For compression of the median nerve at the pronator teres and flexor digitorum superficialis, the cause is almost always due to hypertrophy of the respected muscle. This hypertrophy is from quick, forceful and repeated movements to the involved muscle. Examples include a carpenter or a baseball batter. As the muscle hypertrophies, the signal from the median nerve is diminished resulting in paresthesias in the median nerve distribution (lateral arm and hand) distal to the site of compression. Pain in the volar part of the forearm, often aggravated by repetitive supination and pronation, is a common symptom of pronator involvement. Another indicator is forearm pain with the compression of muscle such as pain in the volar part of the forearm implicating pronator teres. Onset is typically insidious and diagnosis is usually delayed 9 months to 2 years. Epidemiology: Pronator teres syndrome is the second most common cause of median nerve compression behind carpal tunnel syndrome. -
Neuromuscular Disorders Neurology in Practice: Series Editors: Robert A
Neuromuscular Disorders neurology in practice: series editors: robert a. gross, department of neurology, university of rochester medical center, rochester, ny, usa jonathan w. mink, department of neurology, university of rochester medical center,rochester, ny, usa Neuromuscular Disorders edited by Rabi N. Tawil, MD Professor of Neurology University of Rochester Medical Center Rochester, NY, USA Shannon Venance, MD, PhD, FRCPCP Associate Professor of Neurology The University of Western Ontario London, Ontario, Canada A John Wiley & Sons, Ltd., Publication This edition fi rst published 2011, ® 2011 by Blackwell Publishing Ltd Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been merged with Wiley’s global Scientifi c, Technical and Medical business to form Wiley-Blackwell. Registered offi ce: John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial offi ces: 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 111 River Street, Hoboken, NJ 07030-5774, USA For details of our global editorial offi ces, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell The right of the author to be identifi ed as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher. -
CAP-1002 for Advanced DMD: a New Treatment Option
CAP-1002 for Advanced DMD: A New Treatment Option October 24, 2019 NASDAQ: CAPR Forward-Looking Statements Statements in this press release regarding the efficacy, safety, and intended utilization of Capricor's product candidates; the initiation, conduct, size, timing and results of discovery efforts and clinical trials; the pace of enrollment of clinical trials; plans regarding regulatory filings, future research and clinical trials; regulatory developments involving products, including the ability to obtain regulatory approvals or otherwise bring products to market; plans regarding current and future collaborative activities and the ownership of commercial rights; scope, duration, validity and enforceability of intellectual property rights; future royalty streams, revenue projections; expectations with respect to the expected use of proceeds from the recently completed offerings and the anticipated effects of the offerings, and any other statements about Capricor's management team's future expectations, beliefs, goals, plans or prospects constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not statements of historical fact (including statements containing the words "believes," "plans," "could," "anticipates," "expects," "estimates," "should," "target," "will," "would" and similar expressions) should also be considered to be forward- looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by such forward-looking statements. More information about these and other risks that may impact Capricor's business is set forth in Capricor's Annual Report on Form 10-K for the year ended December 31, 2018 as filed with the Securities and Exchange Commission on March 29, 2019, and as amended by its Amendment No. -
Focal Entrapment Neuropathies in Diabetes
Reviews/Commentaries/Position Statements REVIEW ARTICLE Focal Entrapment Neuropathies in Diabetes 1 1 AARON VINIK, MD, PHD LAWRENCE COLEN, MD millimeters]) is a risk factor (8,9). It used 1 2 ANAHIT MEHRABYAN, MD ANDREW BOULTON, MD to be associated with work-related injury, but now seems to be common in people in sedentary positions and is probably re- lated to the use of keyboards and type- MONONEURITIS AND because the treatment may be surgical (2) writers (dentists are particularly prone) ENTRAPMENT SYNDROMES — (Table 1). (10). As a corollary, recent data (3) in 514 Peripheral neuropathies in diabetes are a patients with CTS suggest that there is a diverse group of syndromes, not all of CARPAL TUNNEL threefold risk of having diabetes com- which are the common distal symmetric SYNDROME — Carpal tunnel syn- pared with a normal control group. If rec- polyneuropathy. The focal and multifocal drome (CTS) is the most common entrap- ognized, the diagnosis can be confirmed neuropathies are confined to the distribu- ment neuropathy encountered in diabetic by electrophysiological studies. Therapy tion of single or multiple peripheral patients and occurs as a result of median is simple, with diuretics, splints, local ste- nerves and their involvement is referred nerve compression under the transverse roids, and rest or ultimately surgical re- to as mononeuropathy or mononeuritis carpal ligament. It occurs thrice as fre- lease (11). The unaware physician seldom multiplex. quently in a diabetic population com- realizes that symptoms may spread to the Mononeuropathies are due to vasculitis pared with a normal healthy population whole hand or arm in CTS, and the signs and subsequent ischemia or infarction of (3,4). -
Neuromuscular Disorders of Infancy, Childhood, and Adolescence
Chapter 1 Introduction: Historical Perspectives Darryl C. De Vivo, Basil T. Darras, Monique M. Ryan, and H. Royden Jones, Jr. INTRODUCTION infancy, childhood, and adolescence. Nevertheless, these traditional tests remain useful in certain situations: to The role of the clinician in the diagnosis and treatment of evaluate patients in whom molecular genetic analyses fail a weak child is as important today as it was in the 19th to confirm the initial clinical impression, to facilitate the century, when pediatric neuromuscular diseases were first 1 rapid electrophysiologic diagnosis of a neuropathy or being recognized by such luminaries as Meryon (1852), spinal muscular atrophy, or to focus more precisely on Duchenne (1861),2 Werdnig (1891),3 and Hoffmann 4 5 molecular mechanisms before ordering relatively expen- (1893), and later by Batten (1903). The clinician needs sive molecular genetic tests. The dramatic advances in to react to the concerns of the patient and their parents at DNA diagnostics have added to the complexity of a chal- the first encounter. A detailed medical history and care- lenging clinical field and have left physicians occasion- fully performed physical examination remain the funda- ally uncertain about the relative indications for traditional mental tools and starting point for assessing various tests such as EMG and muscle biopsy. Clearly, all these symptoms and signs. This initial clinical assessment has diagnostic tests remain useful, and it is up to the modern three possible immediate outcomes: (1) the concerns of clinician to make informed decisions, after the initial clin- the patient and family appear to be unfounded, and the ical evaluation, to facilitate an accurate biomolecular clinician can be reassuring. -
Early Surgical Treatment of Pronator Teres Syndrome
www.jkns.or.kr http://dx.doi.org/10.3340/jkns.2014.55.5.296 Print ISSN 2005-3711 On-line ISSN 1598-7876 J Korean Neurosurg Soc 55 (5) : 296-299, 2014 Copyright © 2014 The Korean Neurosurgical Society Case Report Early Surgical Treatment of Pronator Teres Syndrome Ho Jin Lee, M.D.,1 Ilsup Kim, M.D., Ph.D.,2 Jae Taek Hong, M.D., Ph.D.,2 Moon Suk Kim, M.D.2 Department of Neurosurgery,1 Incheon, St. Mary’s Hospital, The Catholic University of Korea, Suwon, Korea Department of Neurosurgery,2 St. Vincent’s Hospital, The Catholic University of Korea, Suwon, Korea We report a rare case of pronator teres syndrome in a young female patient. She reported that her right hand grip had weakened and development of tingling sensation in the first-third fingers two months previous. Thenar muscle atrophy was prominent, and hypoesthesia was also examined on median nerve territory. The pronation test and Tinel sign on the proximal forearm were positive. Severe pinch grip power weakness and production of a weak “OK” sign were also noted. Routine electromyography and nerve conduction velocity showed incomplete median neuropathy above the elbow level with severe axonal loss. Surgical treatment was performed because spontaneous recovery was not seen one month later. Key Words : Pronator teres syndrome · Pronation test · Thenar muscle atrophy · Tinel sign. INTRODUCTION sudden weakness in right hand grip strength and a tingling sen- sation in the thumb, index, and middle fingers (radial side). Pronator teres syndrome (PTS) and anterior interosseous There was no neck or shoulder pain, and no precipitating trau- nerve (AIN) syndrome are proximal median neuropathies of matic event to her affected arm was identified. -
Recommended Policy for Electrodiagnostic Medicine
Recommended Policy for Electrodiagnostic Medicine Executive Summary The electrodiagnostic medicine (EDX) evaluation is an important and useful extension of the clinical evaluation of patients with disorders of the peripheral and/or central nervous system. EDX tests are often crucial to evaluating symptoms, arriving at a proper diagnosis, and in following a disease process and its response to treatment in patients with neuromuscular (NM) disorders. Unfortunately, EDX studies are poorly understood by many in the medical and lay communities. Even more unfortunately, these studies have occasionally been abused by some providers, resulting in overutilization and inappropriate consumption of scarce health resources. The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) has developed this model policy to improve the quality of patient care, to encourage appropriate utilization of the procedures involved, and to assist public and private insurance carriers in developing policy regarding EDX testing. This document contains recommendations which can be used in developing and revising current reimbursement guidelines. This document is based on the AANEM’s prior publications on appropriate EDX evaluations and was further refined by consensus at a conference of 43 experts in the field of EDX medicine. This consensus conference was held to produce guidelines that could be used to identify overutilization. Participants in the conference represented a diversity of practice types and were either neurologists or physiatrists and included the AANEM Board of Directors, committee chairs, Professional Practice Committee members, and other members of the association. Physicians from both academic medical centers and private practice were represented. With the help of the AANEM Professional Practice Committee, the guidelines have continuously been revised to produce this comprehensive policy regarding the optimal use of EDX procedures. -
Neuromuscular Medicine Core Competencies Outline
The American Board of Psychiatry and Neurology Neuromuscular Medicine Core Competencies Outline I. Neuromuscular Patient Care Core Competencies A. GENERAL: Neuromuscular Medicine Specialists shall demonstrate the following abilities: 1. To perform and document relevant history and examination of culturally diverse patient to include as appropriate: a. Chief complaint b. History of present illness c. Past medical history d. Developmental history (especially for children) e. Comprehensive review of both neurologic and general systems f. Biological family history g. Sociocultural history h. Neurological examination and a germane general examination as appropriate to the present illness 2. Delineate appropriate differential diagnoses 3. Formulate, assess and recommend effective management B. FOR NEUROMUSCULAR MEDICINE: Based on comprehensive neurological assessments, Neuromuscular Specialists shall demonstrate the following abilities: 1. To determine: a. If a patient’s symptoms are the result of a disease affecting the central and/or peripheral nervous system or are of another origin (e.g., of a systemic, psychiatric, or psychogenic illness) by performing appropriate neuromuscular evaluation b. An initial diagnostic formulation with differential diagnosis c. Appropriate diagnostic modalities to include laboratory blood, urine, and cerebrospinal fluid analyses, electrodiagnostic, imaging, genetic, and pathologic investigations to evaluate and manage such patients d. Management plan 2. To develop and maintain the technical skills to: a. Perform -
University of Kansas Neuromuscular Fellowship Program Goals, Objectives and Competencies by Rotation
UNIVERSITY OF KANSAS NEUROMUSCULAR FELLOWSHIP PROGRAM GOALS, OBJECTIVES AND COMPETENCIES BY ROTATION The goal of the training in Neuromuscular Medicine is to provide the resident with the opportunity to develop the expertise necessary to evaluate and manage patients with neuromuscular disorders using specialized procedures and techniques. It is the intent of the Neuromuscular Medicine training program to develop neurologists and physical medicine rehabilitation specialist into competent neuromuscular specialists. Neurologists / physiatrists successfully completing the program will be eligible for Neuromuscular Medicine subspecialty certification by the American Board of Psychiatry and Neurology. The objective is to provide residents with the opportunity to develop the expertise necessary to evaluate and manage patients using the procedures and techniques of Neuromuscular Medicine and that all trainees will pass the examination. Neuromuscular Medicine includes the assessment of selective neurological disorders involving central, peripheral and autonomic nervous systems and muscles. Assessment, monitoring and treatment are involved in electrophysiological testing in combination with clinical evaluation. The goals of the training program include extensive experience in neuromuscular clinical evaluation, rehabilitation, nerve and muscle pathology, motor and sensory conduction studies and diagnostic electromyography. Familiarity with single fiber electromyography, skin pathology and autonomic function is included. Clinical competence in Neuromuscular Medicine requires: a. A solid fund of basic clinical knowledge and the ability to maintain it at current levels for a lifetime of continuous education b. The ability to perform an adequate history and physical examination c. The ability to appropriately order and interpret diagnostic tests d. Adequate technical skills to carry out selected diagnostic procedures e. Clinical judgment to critically apply the above data to individual patients f. -
Iatrogenic Neuromuscular Disorders
Iatrogenic Neuromuscular Disorders Peter D. Donofrio, MD Anthony A. Amato, MD James F. Howard, Jr., MD Charles F. Bolton, MD, FRCP(C) 2009 COURSE G AANEM 56th Annual Meeting San Diego, California Copyright © October 2009 American Association of Neuromuscular & Electrodiagnostic Medicine 2621 Superior Drive NW Rochester, MN 55901 Printed by Johnson Printing Company, Inc. ii Iatrogenic Neuromuscular Disorders Faculty Anthony A. Amato, MD Charles F. Bolton, MD, FRCP(C) Department of Neurology Faculty Brigham and Women’s Hospital Department of Medicine Division of Neurology Harvard Medical School Queen’s University Boston, Massachusetts Kingston, Ontario, Canada Dr. Amato is the vice-chairman of the department of neurology and the Dr. Bolton was born in Outlook, Saskatchewan, Canada. He received director of the neuromuscular division and clinical neurophysiology labo- his medical degree from Queen’s University and trained in neurology ratory at Brigham and Women’s Hospital (BWH/MGH) in Boston. He is at the University Hospital, Saskatoon, Saskatchewan, Canada, and at also professor of neurology at Harvard Medical School. He is the director the Mayo Clinic. While at Mayo Clinic, he studied neuromuscular of the Partners Neuromuscular Medicine fellowship program. Dr. Amato disease under Dr. Peter Dyck, and electromyography under Dr. Edward is an author or co-author on over 150 published articles, chapters, and Lambert. Dr. Bolton has had academic appointments at the Universities books. He co-wrote the textbook Neuromuscular Disorders with Dr. Jim of Saskatchewan and Western Ontario, at the Mayo Clinic, and cur- Russell. He has been involved in clinical research trials involving patients rently at Queen’s University. -
Peripheral Nerve Ultrasound Nerve Entrapment • US Findings: Jon A
Peripheral Nerve Ultrasound Nerve Entrapment • US findings: Jon A. Jacobson, M.D. – Nerve enlargement proximal to entrapment • Best appreciated transverse to nerve Professor of Radiology – Abnormally hypoechoic Director, Division of Musculoskeletal Radiology • Especially the connective tissue layers University of Michigan – Variable enlargement or flattening at entrapment site Atrophy Disclosures: Denervation • Edema: hyperechoic • Consultant: Bioclinica • Fatty degeneration: • Book Royalties: Elsevier – Hyperechoic • Advisory Board: Philips – Echogenic interfaces • Educational Grant: RSNA • Atrophy: Asymptomatic • None relevant to this talk – Hyperechoic with decreased muscle size • Compare to other side! Note: all images from the textbook Fundamentals of Musculoskeletal Ultrasound are copyrighted by Elsevier Inc. J Ultrasound Med 1993; 2:73 Extensor Muscles: leg Carpal Tunnel Syndrome: Normal Peripheral Nerve • Proximal median nerve swelling • Ultrasound appearance: – Area: circumferential trace – Hypoechoic nerve – Normal: < 9 mm2 fascicles 2 – Hyperechoic connective – Borderline: 9 – 12 mm tissue – Abnormal: > 12 mm2 • Transverse: • 12.8 mm2 = moderate (83% sens, 95% spec) – Honeycomb • 14.0 mm2 = severe (77% sens, 100% spec) appearance Klauser AS et al. Sem Musculoskel Rad 2010; 14:487 Ooi et al. Skeletal Radiol 2014; 43:1387 Silvestri et al. Radiology 1995; 197:291 Median Nerve 1 Carpal Tunnel Syndrome Bifid Median Nerve + CTS “Notch Sign” • Carpal tunnel syndrome1 • Increase in cross-sectional area of ≥ 4 mm2 • Intraneural hypervascularity: Radius 95% accuracy in 2 Lunate diagnosis of CTS Capitate 1Klauser et al. Radiology 2011; 259; 808 2Mallouhi et al. AJR 2006; 186:1240 Carpal Tunnel Syndrome Pronator Teres Syndrome PT-h • Compare areas: • Median nerve compression – Proximal: pronator quadratus between humeral and ulnar heads PT-u PQ – Distal: carpal tunnel Rad • Trauma, congenital, pronator teres 2 • ≥ 2 mm2 = carpal tunnel 9 mm hypertrophy syndrome • Rare • 99% sensitivity • Forearm pain, numbness, • 100% specificity weakness 2 Jacobson JA, et al. -
NERVE ENTRAPMENT SYNDROMES [ NES ] Disorders of Peripheral Nerve with Pain And/Or Loss of Function [ Motor And/Or Sensory] Due to Chronic Compression
NERVE ENTRAPMENT SYNDROMES [ NES ] Disorders of peripheral nerve with pain and/or loss of function [ motor and/or sensory] due to chronic compression . e.g., carpal tunnel syndrome IMPORTANT: Memorize completely !! Upper limb Nerve place usually referred to median carpal tunnel carpal tunnel syndrome median (anteriiior interosseous) proxilimal forearm anteriiior interosseous Median pronator teres pronator teres syndrome Median ligament of Struthers ligament of Struthers syn Ulnar cubital tunnel cubital tunnel syndrome Ulnar Guyon's canal Guyon's canal syndrome radial axilla radial nerve compression radial spiral groove radial nerve compression radial (posterior interosseous ) proximal forearm posterior interosseous nerve radial (superficial radial) distal forearm Wartenberg's Syndrome suprascapular suprascapular notch etc Etc etc ETC ETC ETC NES Def: results from chronic injury to nerve as it travels through an osseoligamentous structure, or between muscles bundles May have an underlying developmental anomaly or variant Repetitive motion slaps, rubs, compresses the n. Relatively common Often seen in athletes, younger patients Chronic NES Repetitive injury may lead to edema, ischemia, and finally alteration to the nerve sheath, even demyelinization Eventually complete recovery may not be possible, and there is also the potential for ‘phantom limb’ type symptoms that become centralized in the brain and ‘replay’ even after the pathology is fixed. Early recognition and intervention is critical. PUDENDAL NERVE ENTTTRAPMENT