INFECTION AND IMMUNITY

Volume 78 February 2010 No. 2

EDITORIAL

Lost in Translation—Basic Science in the Era of Ferric C. Fang and Arturo 563–566 Translational Research Casadevall

SPOTLIGHT Articles of Significant Interest Selected from This Issue by 567 the Editors

MINIREVIEW Waging War against Uropathogenic Escherichia coli: Kelsey E. Sivick and Harry L. T. 568–585 Winning Back the Urinary Tract Mobley

MOLECULAR PATHOGENESIS denticola Suppresses Expression of Human ␤- Ji Eun Shin, Young Sook Kim, Ju- 672–679 Defensin-3 in Gingival Epithelial Cells through Inhibition of Eun Oh, Byung-Moo Min, and the Toll-Like Receptor 2 Axis Youngnim Choi Ferrous Iron Transporter FeoB1 Cecilia Anaya-Bergman, Jia He, 688–696 Influences Sensitivity to Oxidative Stress Kevin Jones, Hiroshi Miyazaki, Andrew Yeudall, and Janina P. Lewis The Virulence Transcriptional Activator AphA Enhances Menghua Yang, Erin M. Frey, Zhi 697–703 Biofilm Formation by Vibrio cholerae by Activating Liu, Rima Bishar, and Jun Zhu Expression of the Biofilm Regulator VpsT The Streptococcus pneumoniae Capsule Inhibits Complement Catherine Hyams, Emilie 704–715 Activity and Phagocytosis by Multiple Camberlein, Jonathan M. Cohen, Mechanisms Katie Bax, and Jeremy S. Brown Streptococcus pneumoniae Resistance to Complement- Catherine Hyams, Jose Yuste, Katie 716–725 Mediated Immunity Is Dependent on the Capsular Serotype Bax, Emilie Camberlein, Jeffrey N. Weiser, and Jeremy S. Brown Yersinia pestis Two-Component Gene Regulatory Systems Jason L. O’Loughlin, Justin L. 773–782 Promote Survival in Human Spinner, Scott A. Minnich, and Scott D. Kobayashi Cytolethal Distending Toxin from Aggregatibacter Oranart Matangkasombut, 783–792

actinomycetemcomitans Induces DNA Damage, S/G2 Cell Roongtiwa Wattanawaraporn, Keiko Cycle Arrest, and Caspase-Independent Death in a Tsuruda, Masaru Ohara, Motoyuki Saccharomyces cerevisiae Model Sugai, and Skorn Mongkolsuk Ferredoxin Is Involved in Secretion of Cytotoxic Necrotizing Hao Yu and Kwang Sik Kim 838–844 Factor 1 across the Cytoplasmic Membrane in Escherichia coli K1

CELLULAR MICROBIOLOGY: -HOST CELL MOLECULAR INTERACTIONS Association of Vibrio parahaemolyticus Thermostable Direct Shigeaki Matsuda, Toshio Kodama, 603–610 Hemolysin with Lipid Rafts Is Essential for Cytotoxicity but Natsumi Okada, Kanna Okayama, Not Hemolytic Activity Takeshi Honda, and Tetsuya Iida Major Secretory of the Helminth Fasciola hepatica David J. Dowling, Clare M. 793–801 Activate a Suppressive Dendritic Cell Phenotype That Hamilton, Sheila Donnelly, James Attenuates Th17 Cells but Fails To Activate Th2 Immune La Course, Peter M. Brophy, John Responses Dalton, and Sandra M. O’Neill

Continued on following page Continued from preceding page

BACTERIAL INFECTIONS Genetic Control of the Innate Immune Response to Vivian M. Benoit, Annett Petrich, 586–594 hermsii Influences the Course of in Inbred Kishore R. Alugupalli, Robin Strains of Mice Marty-Roix, Annette Moter, John M. Leong, and Victor L. Boyartchuk Invasion of Melanoma Cells by Mycoplasma hyorhinis: Jonathan D. Kornspan, Mark 611–617 Enhancement by Protease Treatment Tarshis, and Shlomo Rottem Mycoplasma genitalium Rapidly Disseminates to the Upper Chris L. McGowin, Rae Ann 726–736 Reproductive Tracts and Knees of Female Mice following Spagnuolo, and Richard B. Pyles Vaginal Inoculation Critical Roles of Complement and in Host Bernt Christian Hellerud, Audun 802–809 Defense Mechanisms against as Aase, Tove Karin Herstad, Lisbeth Revealed by Human Complement Genetic Deficiencies Meyer Næss, Lisa Høyem Kristiansen, Anne-Marie Siebke Trøseid, Morten Harboe, Knut Tore Lappega˚rd, Petter Brandtzæg, E. Arne Høiby, and Tom Eirik Mollnes

HOST RESPONSE AND INFLAMMATION Differential Patterns of Liver Proteins in Experimental B. Manivannan, P. Rawson, T. W. 618–628 Murine Hepatosplenic Schistosomiasis Jordan, W. E. Secor, and A. C. La Flamme Protease-Activated Receptor 2 Has Pivotal Roles in Cellular David M. Wong, Vivian Tam, 629–638 Mechanisms Involved in Experimental Periodontitis Roselind Lam, Katrina A. Walsh, Liliana Tatarczuch, Charles N. Pagel, Eric C. Reynolds, Neil M. O’Brien-Simpson, Eleanor J. Mackie, and Robert N. Pike Transitions in Oral and Intestinal Microflora Composition Mizuho Hasegawa, Toshifumi 639–650 and Innate Immune Receptor-Dependent Stimulation during Osaka, Kazuki Tawaratsumida, Mouse Development Takashi Yamazaki, Hiroyuki Tada, Grace Y. Chen, Satoshi Tsuneda, Gabriel Nu´n˜ez, and Naohiro Inohara Stimulates Dendritic Cells To Induce Wafa Khamri, Marjorie M. Walker, 845–853 ,Interleukin-17 Expression from CD4؉ T Lymphocytes Peter Clark, John C. Atherton Mark R. Thursz, Kathleen B. Bamford, Robert I. Lechler, and Giovanna Lombardi Infection of Mast Cells with Live Streptococci Causes a Elin Ro¨nnberg, Bengt Guss, and 854–864 Toll-Like Receptor 2- and Cell-Cell Contact-Dependent Gunnar Pejler and Chemokine Response Toll-Like Receptor Stimulation Enhances Phagocytosis and Sandra Ribes, Sandra Ebert, 865–871 Intracellular Killing of Nonencapsulated and Encapsulated Tommy Regen, Amit Agarwal, Streptococcus pneumoniae by Murine Microglia Simone C. Tauber, Dirk Czesnik, Annette Spreer, Stephanie Bunkowski, Helmut Eiffert, Uwe- Karsten Hanisch, Sven Hammerschmidt, and Roland Nau

FUNGAL AND PARASITIC INFECTIONS Baculovirus-Based Nasal Drop Vaccine Confers Complete Shigeto Yoshida, Hitomi Araki, and 595–602 Protection against by Natural Boosting of Vaccine- Takashi Yokomine Induced Antibodies in Mice Protection against Lethal Neospora caninum Infection in Diana Marcela Penarete-Vargas, 651–660 Mice Induced by Heterologous with a mic1 mic3 Marie Noelle Me´ve´lec, Sarah Dion, Knockout Toxoplasma gondii Strain Edouard Se`che, Isabelle Dimier- Poisson, and Thierry Fandeur Continued on following page Continued from preceding page

Alanine Mutagenesis of the Primary Antigenic Escape Sheetij Dutta, Lisa S. Dlugosz, 661–671 Residue Cluster, C1, of Apical Membrane 1 Joshua W. Clayton, Christopher D. Pool, J. David Haynes, Robert A. Gasser III, and Adrian H. Batchelor Growth-Inhibitory Antibodies Are Not Necessary for E. Elsa Herdiana Murhandarwati, 680–687 Protective Immunity to Malaria Infection Lina Wang, Harini D. de Silva, Charles Ma, Magdalena Plebanski, Casilda G. Black, and Ross L. Coppel In Vitro Growth-Inhibitory Activity and Malaria Risk in a Peter D. Crompton, Kazutoyo 737–745 Cohort Study in Mali Miura, Boubacar Traore, Kassoum Kayentao, Aissata Ongoiba, Greta Weiss, Safiatou Doumbo, Didier Doumtabe, Younoussou Kone, Chiung-Yu Huang, Ogobara K. Doumbo, Louis H. Miller, Carole A. Long, and Susan K. Pierce Genetic Immunization Converts the cruzi B- Marianne A. Bryan and Karen A. 810–822 Cell Mitogen Proline Racemase to an Effective Immunogen Norris Aspergillus fumigatus LaeA-Mediated Phagocytosis Is Taylor R. T. Dagenais, Steve S. 823–829 Associated with a Decreased Hydrophobin Layer Giles, Vishukumar Aimanianda, Jean-Paul Latge´, Christina M. Hull, and Nancy P. Keller

MICROBIAL IMMUNITY AND VACCINES Evaluation of Flagella and Flagellin of Pseudomonas Victoria L. Campodo´nico, Nicola´s J. 746–755 aeruginosa as Vaccines Llosa, Martha Grout, Gerd Do¨ring, Toma´s Maira-Litra´n, and Gerald B. Pier Efficient Serum Clearance of Botulinum Neurotoxin Jorge Sepulveda, Jean Mukherjee, 756–763 Achieved Using a Pool of Small Antitoxin Binding Agents Saul Tzipori, Lance L. Simpson, and Charles B. Shoemaker Synthetic ␤-(136)-Linked N-Acetylated and Nonacetylated Marina L. Gening, Toma´s Maira- 764–772 Oligoglucosamines Used To Produce Conjugate Vaccines for Litra´n, Andrea Kropec, David Bacterial Skurnik, Martha Grout, Yury E. Tsvetkov, Nikolay E. Nifantiev, and Gerald B. Pier Morphine Disrupts Interleukin-23 (IL-23)/IL-17-Mediated Jing Ma, Jinghua Wang, Jing Wan, 830–837 Pulmonary Mucosal Host Defense against Streptococcus Richard Charboneau, Yaping pneumoniae Infection Chang, Roderick A. Barke, and Sabita Roy Plasmodium falciparum Merozoite Surface Protein 1 (MSP- Suman Mazumdar, Paushali 872–883 1)–MSP-3 Chimeric Protein: Immunogenicity Determined Mukherjee, Syed Shams Yazdani, S. with Human-Compatible Adjuvants and Induction of K. Jain, Asif Mohmmed, and Protective Immune Response Virander Singh Chauhan

AUTHOR’S CORRECTION Blood Transfusion Alters the Course and Outcome of George S. Yap and Mary M. 884 Plasmodium chabaudi AS Infection in Mice Stevenson

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): Spirochete-erythrocyte inter- action and innate immune defense. Borrelia hermsii spirochetes (orange) labeled by fluorescence in situ hybridization attach to erythrocytes (green) within a coronary vessel of an infected BALB/c rag2Ϫ/Ϫ mouse. (See related article on page 586.)