Vaccines Proliferate . MeasuringBurden ofDiseaseasRotavirus,Pneumococcal • NewVaccines: AFocusonPneumococcus,RotavirusandHPV. • Improving PneumococcalDiseaseSurveillance:LearningbyDoing. • LookingCloseratPneumococcalDiseaseinLatinAmerica. • TheGlobalBurden ofPneumococcalDisease. • Session I:EpidemiologyandSurveillanceofPneumococcalDisease AsImmunizationOfferings Multiply, EvidenceisAllImportant. • PotentialEmergence ofNon-Vaccine Serotypes. • CapturingtheMosaicofPneumococcalSerotypes inLatinAmerica . • Providing aPolicyFoundationforImmunizationPrograms. • Answering theManyQuestionsSurrounding HPVVaccines. • NewTools forReducingCervical CancerintheAmericas. • Session III:HPVSurveillanceandVaccines AsPricesLoomLarge, Argentina EvaluatesPneumococcalVaccines. • MeasuringtheEfficacyofNewVaccines forPneumococcus . • PneumococcalVaccine Development atPfizer. • PneumococcalVaccine DevelopmentatGSK. • Session II:PneumococcalVaccines andCost-Effectiveness Studies SettingtheStageforaNewEraofImmunizations. • Introduction Session Table of Contents –Sidebar:LaboratorySupport fortheIntroduction ofHPVVaccines...... 10 13 12 15 16 19 26 23 27 22 21 24 21 9 7 6 6

1 Regional Symposium of New Vaccines 2 Regional Symposium of New Vaccines Conclusion. • –Sidebar:TheImportanceoftheRevolvingFund. RegionalPlanforH1N1Vaccination. • Session V: OtherTopics –Sidebar:RotavirusVaccine Safety:StayingAlert MonitoringRotavirusSerotypes intheRegion. • CaseStudyofRotavirusEffectiveness inElSalvador . • RotavirusImmunizationintheAmericas. • TheGlobalBurden ofRotavirus. • Session IV: RotavirusEpidemiology, SurveillanceandVaccines forIntussusception...... 39s 38 33 29 37 36 34 31 said 15-yearsworthofdatagathered bylaboratories inthe Gabastou ofPAHO’s SIREVA vaccinesurveillancenetwork serotypes targeted by eachformulation.Jean-March vaccines. Thenumbersdenote thenumberofdisease 10 andPCV13orthe7-valent,10-valent,13-valent conjugated vaccines,commonlyreferred toasPCV7, pneumococcus inchildren, whichare thepneumococcal There are currently three vaccinesavailable forfighting in LatinAmerica,higherthanrotavirus.” diseases are “themaincauseofvaccinepreventable deaths the SabinVaccine Institutepointedoutthatpneumococcal other invasivepneumococcaldiseases.Ciro deQuadros of are causedbypneumonia, 14%bymeningitisand13% that intheAmericas,about73%ofpneumococcaldeaths in theregion. Susan Wang oftheWHOsaiddatareveal D O and meningitis.Rotaviruscausessevere diarrheathat pneumococcus, whichincludepneumococcalpneumonia million children dieeveryyearfrom ailmentscausedby Health Organization (WHO)estimatesthatupto1 mankind’s mostefficientandprolific killers.TheWorld available targeting thesediseases,whichare someof Overthelastfewyears,newvaccineshavebecome pneumococcus, , andhumanpapillomavirus. focused onissuesrelated toadoptingimmunizationsfor Disease Control andPrevention (CDC).Theirdiscussions Health Organization (PAHO), andtheU.S.Centersfor of Health,theSabinVaccine Institute,thePanAmerican New Vaccines, whichwassponsored byPeru’s Ministry came toLima,PeruattendtheRegionalSymposiumon physicians, researchers andother concernedstakeholders pneumococcal ata presented at theconference showedthateachyear, n December1and2,2009,160governmentleaders, Pneumococcal DiseaseandImmunization Executive Summary disease kills about 33,000 children under five new vaccineserotypes—that is,theserotypes thatare not vaccine manufacturers havemeasured thecapacityof is knownaboutthe7-valentvaccine. Atissuewashow 10-valent and13-valentformulations—is onparwithwhat efficacy forthetwonewestpneumococcalvaccines—the There wasextensivediscussiononwhetherthedata Colombia, ElSalvador, Ecuador, andPanama. risk children lessthanoneyearofage:Argentina, Brazil, the pneumococcalvaccinepubliclyavailabletohigh- public immunizationprogram. Sixcountrieswere making and Barbados—hadaddedpneumococcalvaccinetotheir United States,Canada,Mexico,CostaRica,Uruguay, Asoflate2009,sevencountriesint