Supporting Information for Proteomics DOI 10.1002/pmic.200600956

Alexey V. Pshezhetsky, Michael Fedjaev, Lyudmila Ashmarina, Alexander Mazur, Lorne Budman, Daniel Sinnet, Damian Labuda, Jean-Franc¸ ois Beaulieu, Daniel Mnard, Ilya Nifant’ev and Þmile Levy

Subcellular proteomics of cell differentiation: Quantitative analysis of the plasma membrane proteome of Caco-2 cells

ª 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.proteomics-journal.com Supplemental Table 1. Proteins identified in the membranes of Caco-2 cells by SDS-PAGE-ηLC-MS/MS and IT-2D-LC-MS/MS methods.

DC – detected only in DC; PC – detected only in PC; blank cells - protein was not detected or ratio could not be calculated.

IT-2D-LC- IT-2D-LC- SDS-PAGE- MS/MS MS/MS LC-MS/MS (IonTrap) (QTrap)

UniProt Protein name ectra ectra ectra GO Cellular Compartment GO Molecular Function GO Biological Process ID p p p n score, n score, n score, i i i e e e Coverage, % t t t ro ro ro P P P numer of pairs numer of pairs numer of pairs number of s number of s number of s Ratio DC/PC, stdev,Ratio DC/PC, stdev,Ratio DC/PC, stdev,Ratio DC/PC, number of peptides, number of peptides, number of peptides, 0005515 protein binding Keratin, type I cytoskeletal 19 1520 1.3 403 3.7 503 5.2 0005200 structural constituent of 0043034 costamere 0045214 sarcomere organization P08727 (Cytokeratin-19) (CK-19) (Keratin-19) 79 95 ±0.2 25 ±0.4 33 ±0.8 cytoskeleton 0005882 intermediate filament (K19) 1004 (25) 51 (41) 79 (58) 0008307 structural constituent of muscle

1019 3.6 574 3.0 700 4.3 0004645 phosphorylase activity 0005975 carbohydrate metabolism Q641R5 Phosphorylase, glycogen 59 64 ±0.5 39 ±0.2 44 ±0.6 0030170 pyridoxal phosphate

468 (28) 83 (55) 127 (89) binding

1436 -1.5 344 3.0 405 3.7 0005515 protein binding 0007010 cytoskeleton Keratin, type II cytoskeletal 8 0005882 intermediate filament P05787 70 92 ±0.4 24 ±0.2 28 ±0.4 0005198 structural molecule organization and biogenesis (Cytokeratin-8) (CK-8) (Keratin-8) (K8) 1662 (25) 53 (42) 63 (41) activity

717 1.4 519 -1.3 814 1.1 0005515 protein binding 0006886 intracellular protein 0030118 clathrin coat Q00610 Clathrin heavy chain 1 (CLH-17) 50 44 ±0.4 32 ±0.1 48 ±0.1 0005198 structural molecule transport

338 (30) 62 (41) 148 (104) activity

0051015 actin filament binding 0005737 cytoplasm 0051272 positive regulation of cell 0005178 integrin binding 954 5.6 285 2.1 801 2.2 0005634 nucleus motility Alpha-actinin-4 (Non-muscle alpha- 0001882 nucleoside binding O43707 60 58 ±0.7 18 ±0.1 49 ±0.2 0048471 perinuclear region 0042981 regulation of apoptosis actinin 4) (F-actin cross-linking protein) 0005515 protein binding 254 (24) 28 (18) 101 (68) 0043234 protein complex 0000074 regulation of progression 0042803 protein 0031143 pseudopodium through cell cycle homodimerization activity

801 -1.2 338 1.5 652 2.0 0006457 protein folding Heat shock cognate 71 kDa protein 0009986 cell surface 0042623 ATPase activity, coupled P11142 46 47 ±0.1 22 ±0.1 38 ±0.2 0006986 response to unfolded (Heat shock 70 kDa protein 8) 0005622 intracellular 0005515 protein binding 209 (19) 48 (31) 116 (81) protein

652 -1.3 336 1.3 558 1.9 0005524 ATP binding 0006457 protein folding

Q9NTK6 Hypothetical protein DKFZp761K0511 38 43 ±0.1 21 ±0.1 35 ±0.2 0000166 nucleotide binding 0006986 response to unfolded

166 (19) 41 (29) 87 (58) 0051082 unfolded protein binding protein 577 -1.0 269 2.1 555 3.2 0019899 enzyme binding P62258 14-3-3 protein epsilon (14-3-3E) 55 34 ±0.3 18 ±0.1 36 ±0.5

259 (8) 33 (25) 68 (51)

358 2.7 213 3.4 682 4.7 0005198 structural molecule 0005856 cytoskeleton P58107 Epiplakin (450 kDa epidermal antigen) 50 22 ±0.5 14 ±0.2 44 ±1.0 activity

91 (3) 21 (14) 77 (52)

509 1.5 231 2.0 428 2.7 0005737 cytoplasm 0005488 binding

Q4VX75 Villin 2 (Ezrin) 47 35 ±0.2 16 ±0.2 29 ±0.2 0005856 cytoskeleton 0008092 cytoskeletal protein

216 (18) 45 (42) 74 (58) 0016020 membrane binding

523 179 10.2 451 7.5 0004553 hydrolase activity, Sucrase-isomaltase (Alpha- 0005975 carbohydrate metabolism Q1JQ80 34 33 DC 12 ±2.3 29 ±1.3 hydrolyzing O-glycosyl glucosidase) 99 18 (8) 64 (36)

0005525 GTP binding 0003924 GTPase activity 450 3.0 228 3.1 431 3.1 0005737 cytoplasm 0007018 microtubule-based 0000166 nucleotide binding Q8IZ29 Tubulin, beta 2C 72 28 ±0.5 15 ±0.3 25 ±0.3 0005874 microtubule movement 0005198 structural molecule 372 (13) 42 (30) 110 (73) 0043234 protein complex 0051258 protein polymerization activity

Dipeptidyl peptidase 4 (EC 3.4.14.5) (Dipeptidyl peptidase IV) (DPP IV) (T- cell activation antigen CD26) (TP103) 414 4.3 279 2.1 332 2.9 0004274 dipeptidyl-peptidase IV 0006955 immune response P27487 (Adenosine deaminase complexing 49 27 ±1.3 19 ±0.1 21 ±0.3 activity

protein 2) (ADABP) [Contains: 150 (14) 44 (30) 71 (45) Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase 0004134 4-alpha- glucanotransferase activity Amylo-1,6-glucosidase, 4-alpha- 238 1.8 209 1.5 552 2.1 0004135 amylo-alpha-1,6- 0005975 carbohydrate metabolism Q59H92 glucanotransferase isoform 1 variant 40 17 ±0.4 13 ±0.1 35 ±0.2 glucosidase activity 0005978 glycogen biosynthesis (Fragment) 53 (9) 28 (19) 74 (50) 0043169 cation binding 0016740 transferase activity

L-lactate dehydrogenase A chain (EC 446 21.5 233 3.2 305 4.2 0004459 L-lactate dehydrogenase 1.1.1.27) (LDH-A) (LDH muscle subunit) 0005829 cytosol P00338 64 27 ±3.2 15 ±0.4 20 ±0.6 activity (LDH-M) (Proliferation-inducing gene 19 262 (9) 25 (19) 51 (37) 0005515 protein binding protein) (NY-REN-59 antigen)

328 2.9 267 3.0 386 3.4 0007010 cytoskeleton 0003779 actin binding Q53F91 Villin 1 variant (Fragment) 47 21 ±0.4 17 ±0.2 24 ±0.4 organization and biogenesis

140 (14) 41 (28) 72 (44)

394 1.4 263 2.1 296 2.0 0005515 protein binding P63261 Actin, cytoplasmic 2 (Gamma-actin) 60 25 ±0.4 16 ±0.2 18 ±0.1

719 (17) 95 (49) 159 (96) 0005509 calcium ion binding 0005544 calcium-dependent 386 -1.9 260 1.2 296 2.0 phospholipid binding

Q8TBV2 Annexin A2 61 23 ±0.2 17 ±0.1 18 ±0.2 0008092 cytoskeletal protein

338 (22) 53 (38) 75 (38) binding 0004859 phospholipase inhibitor activity

ANXA4 protein (Hypothetical protein 342 7.6 233 4.0 299 4.6 0005509 calcium ion binding

Q6LES2 ANXA4) (Proliferation-inducing protein 71 21 ±1.0 14 ±0.2 19 ±0.6 0005544 calcium-dependent

28) (Fragment) 403 (14) 37 (28) 58 (37) phospholipid binding

0006886 intracellular protein 513 1.5 38 -1.3 303 -1.1 0030130 clathrin coat of trans- 0005488 binding transport Q20WL3 AP1B1 protein 39 32 ±0.6 3 ±0.1 19 ±0.1 Golgi network vesicle 0006461 protein complex 147 (21) 3 (2) 27 (18) assembly

387 2.3 89 2.9 375 2.5 0003779 actin binding Q5JRN9 Plastin 3 (T isoform) 41 27 ±0.3 6 ±1.1 25 ±0.2 0005509 calcium ion binding 72 (9) 7 (2) 39 (22)

329 2.9 190 2.4 310 2.4

Q9UM05 ABP130 33 22 ±1.1 13 ±0.2 19 ±0.2

78 (10) 16 (15) 52 (39)

Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) 0031698 beta-2 adrenergic exchange regulatory cofactor NHE-RF) 93 -1.1 93 1.7 199 3.6 receptor binding 0006461 protein complex 0015629 actin cytoskeleton O14745 (NHERF-1) (Regulatory cofactor of 46 5 ±0.1 6 ±0.2 12 ±1.0 0005515 protein binding assembly

Na(+)/H(+) exchanger) (Sodium- 60 (5) 16 (11) 25 (19) 0017155 sodium:hydrogen hydrogen exchanger regulatory factor 1) antiporter regulator activity (Solute carrier family 9

Neuroblast differentiation-associated 51 184 -1.3 558 1.0 0007399 nervous system 0005634 nucleus Q09666 protein AHNAK (Desmoyokin) 17 4 PC 12 ±0.1 34 ±0.1 development

(Fragments) 6 14 (5) 48 (26)

Filamin-B (FLN-B) (Beta-filamin) (Actin- binding-like protein) (Thyroid 0030036 actin cytoskeleton 221 3.5 77 1.5 478 2.4 autoantigen) (Truncated actin-binding 0015629 actin cytoskeleton 0003779 actin binding organization and biogenesis O75369 24 16 ±1.5 5 ±0.1 30 ±0.2 protein) (Truncated ABP) (ABP-280 0016021 integral to membrane 0005515 protein binding 0007016 cytoskeletal anchoring 40 (3) 7 (2) 45 (30) homolog) (ABP-278) (Filamin 3) 0007165 signal transduction (Filamin homolog 1) (Fh1)

0006355 regulation of 281 -5.9 130 -2.4 331 -1.4 0000166 nucleotide binding transcription, DNA-dependent Q9NZI8 MRNA-binding protein CRDBP 29 19 ±1.0 9 ±0.3 20 ±0.1 0003723 RNA binding 0006445 regulation of translation 87 (5) 15 (7) 43 (28) 0006350 transcription

0006000 fructose metabolism Fructose-bisphosphate aldolase A (EC 282 5.7 144 2.9 285 4.2 0004332 fructose-bisphosphate 0006096 glycolysis P04075 4.1.2.13) (Muscle-type aldolase) (Lung 66 18 ±0.8 9 ±0.4 17 ±0.6 aldolase activity 0006941 striated muscle cancer antigen NY-LU-1) 100 (9) 14 (9) 37 (26) contraction Annexin A3 (Annexin III) (Lipocortin III) (Placental anticoagulant protein III) 292 -3.4 171 -1.9 240 -1.4 0005737 cytoplasm 0007165 signal transduction P12429 (PAP-III) (35-alpha calcimedin) (Inositol 63 19 ±1.1 10 ±0.3 15 ±0.2

1,2-cyclic phosphate 2- 215 (15) 23 (17) 45 (25) phosphohydrolase)

116 -1.8 90 1.3 473 2.0 Non-muscle myosin heavy polypeptide 0016459 myosin 0005524 ATP binding Q60FE2 18 7 ±0.9 6 ±0.1 30 ±0.5 9 0003774 motor activity 19 (3) 11 (7) 51 (31)

262 2.3 135 2.1 275 3.0 Tubulin alpha-ubiquitous chain (Alpha- P68363 51 16 ±0.5 8 ±0.3 16 ±0.3 tubulin ubiquitous) (Tubulin K-alpha-1) 515 (12) 28 (17) 63 (39)

324 2.4 110 3.5 227 5.2 0004618 phosphoglycerate kinase 0006096 glycolysis Q5J7W1 Phosphoglycerate kinase (EC 2.7.2.3) 68 20 ±0.6 7 ±0.6 14 ±0.7 activity

118 (13) 10 (6) 43 (29) 0016740 transferase activity

0015991 ATP hydrolysis coupled proton transport 0030641 hydrogen ion Sodium/potassium-transporting ATPase 194 -2.0 140 -1.2 302 -1.0 0005624 membrane fraction 0005515 protein binding homeostasis P05023 alpha-1 chain precursor (EC 3.6.3.9) 32 13 ±0.4 9 ±0.1 19 ±0.1 0005890 sodium:potassium- 0005391 sodium:potassium- 0006813 potassium ion transport (Sodium pump 1) (Na+/K+ ATPase 1) 40 (8) 20 (16) 45 (35) exchanging ATPase complex exchanging ATPase activity 0006814 sodium ion transport 0030317 sperm motility

320 -2.1 161 -1.6 148 1.3 0005509 calcium ion binding 0050819 negative regulation of ANXA5 protein (Hypothetical protein Q6FHB3 76 21 ±0.3 10 ±0.1 10 ±0.1 0005544 calcium-dependent coagulation ANXA5) (Fragment) 271 (16) 26 (19) 38 (25) phospholipid binding

Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic 217 2.1 164 3.6 232 3.6 0004450 isocitrate dehydrogenase 0005737 cytoplasm 0005975 carbohydrate metabolism O75874 NADP-isocitrate dehydrogenase) 56 14 ±0.9 11 ±0.5 15 ±0.6 (NADP+) activity 0005829 cytosol 0006102 isocitrate metabolism (Oxalosuccinate decarboxylase) (IDH) 72 (9) 17 (12) 26 (19) (NADP(+)-specific ICDH) (IDP)

179 4.5 145 2.4 280 2.2 0016192 vesicle-mediated Protein transport protein Sec23A 0005829 cytosol 0005515 protein binding Q15436 29 10 ±1.5 9 ±0.2 16 ±0.2 transport (SEC23-related protein A) 0005783 endoplasmic reticulum 72 (5) 22 (14) 48 (38)

Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) (Pyruvate kinase muscle 164 8.4 171 2.9 256 3.3 0005737 cytoplasm 0005515 protein binding 0006096 glycolysis P14618 isozyme) (Pyruvate kinase 2/3) 46 10 ±1.9 11 ±0.3 15 ±0.6 0005829 cytosol 0004743 pyruvate kinase activity (Cytosolic thyroid hormone-binding 103 (7) 19 (14) 39 (25) protein) (CTHBP) (THBP1)

191 1.5 183 2.5 210 3.8 Glycogen [starch] synthase, muscle (EC P13807 33 12 ±0.1 11 ±0.2 13 ±0.5 2.4.1.11) 84 (8) 20 (7) 33 (19) 232 -1.0 66 1.4 263 1.4

Q5JWF2 GNAS complex locus 25 16 ±0.2 5 ±0.1 18 ±0.3

45 (9) 10 (9) 34 (20)

0016829 lyase activity 195 6.6 127 2.7 212 3.6 0000015 phosphopyruvate 0000287 magnesium ion binding 0006096 glycolysis Q53FT9 Enolase 1 variant (Fragment) 53 11 ±1.0 7 ±0.2 13 ±0.5 hydratase complex 0004634 phosphopyruvate 70 (8) 22 (15) 39 (27) hydratase activity

232 2.1 131 6.4 161 8.4 Creatine kinase B-type (EC 2.7.3.2) 0004111 creatine kinase activity P12277 55 13 ±0.4 7 ±1.4 9 ±1.3 (Creatine kinase B chain) (B-CK) 182 (11) 21 (10) 49 (28)

Triosephosphate isomerase (EC 201 2.3 104 4.0 211 5.5 0016853 isomerase activity 0008152 metabolism Q6FHP9 5.3.1.1) (TIM) (Triose-phosphate 79 12 ±0.6 7 ±0.8 12 ±0.8 0004807 triose-phosphate

isomerase) (Fragment) 97 (6) 12 (9) 34 (23) isomerase activity

0030530 heterogeneous nuclear Heterogeneous nuclear 227 -17.5 69 -2.1 214 -2.0 0000398 nuclear mRNA splicing, ribonucleoprotein com 0005515 protein binding P22626 ribonucleoproteins A2/B1 (hnRNP A2 / 38 16 ±1.9 5 ±0.5 14 ±0.3 via spliceosome IC:HGNC 0005634 nucleus 0003723 RNA binding hnRNP B1) 45 (2) 7 (5) 21 (13) 0005681 spliceosome complex

0005737 cytoplasm Annexin A11 (Annexin XI) (Calcyclin- 148 1.3 135 -1.2 217 1.2 0005635 nuclear envelope 0005543 phospholipid binding 0006955 immune response P50995 associated annexin 50) (CAP-50) (56 31 10 ±0.4 9 ±0.1 13 ±0.2 0005654 nucleoplasm 0005515 protein binding kDa autoantigen) 44 (8) 12 (12) 27 (23) 0005634 nucleus

0005524 ATP binding 0015031 protein transport 0005525 GTP binding 250 1.6 62 1.4 180 1.2 0006355 regulation of RAB1A, member RAS oncogene family 0005622 intracellular 0000166 nucleotide binding Q5U0I6 46 17 ±0.6 4 ±0.1 12 ±0.1 transcription, DNA-dependent (RAB1A protein) 0016020 membrane 0008134 transcription factor 102 (7) 10 (7) 27 (21) 0007264 small GTPase mediated binding signal transduction

217 5.1 107 2.0 157 3.5 0004365 glyceraldehyde-3- 0006006 glucose metabolism Q53X65 GAPD protein (Fragment) 55 12 ±2.9 7 ±0.2 9 ±0.3 phosphate dehydrogenase (p 0006096 glycolysis 509 (10) 8 (5) 50 (32) 0051287 NAD binding

Catenin alpha-1 (Cadherin-associated 253 -1.3 38 -1.1 186 1.1 0043297 apical junction assembly 0005515 protein binding P35221 protein) (Alpha E-catenin) (NY-REN-13 33 17 ±0.2 3 - 12 ±0.2 0007155 cell adhesion 0017166 vinculin binding antigen) 48 (8) 3 (1) 22 (12) NAS:ProtInc

105 1.9 63 -1.1 309 1.8 Myosin Ib (Myosin I alpha) (MMI-alpha) O43795 22 8 ±0.4 5 ±0.1 20 ±0.4 (MMIa) (MYH-1c) 18 (4) 5 (3) 31 (20) 404 -1.2 18 2.7 40 5.2 0005200 structural constituent of Keratin, type I cytoskeletal 9 0008544 epidermis development P35527 51 25 ±0.6 1 - 2 ±1.9 cytoskeleton (Cytokeratin-9) (CK-9) (Keratin-9) (K9) 300 (17) 1 (1) 4 (2)

178 3.0 105 3.0 140 3.8 0006916 anti-apoptosis Glutathione S-transferase P (EC 0005737 cytoplasm P09211 65 10 ±0.8 7 ±0.5 9 ±0.7 0007417 central nervous system 2.5.1.18) (GST class-pi) (GSTP1-1) 124 (9) 14 (6) 27 (18) development

0048037 cofactor binding 0016788 hydrolase activity, acting on ester bonds 66 1.9 64 -1.0 287 1.4 0016491 oxidoreductase activity 0009058 biosynthesis Q4LE83 FASN variant protein (Fragment) 14 5 ±0.2 4 ±0.1 18 ±0.1 0031177 phosphopantetheine 0006633 fatty acid biosynthesis 8 (3) 5 (4) 28 (16) binding 0016740 transferase activit

114 3.4 82 1.9 221 2.8 0006888 ER to Golgi vesicle- Protein transport protein Sec24C 0030127 COPII vesicle coat 0005515 protein binding P53992 23 9 ±0.3 6 ±0.2 13 ±0.5 mediated transport (SEC24-related protein C) 34 (5) 9 (7) 27 (17)

64 3.6 130 1.1 215 1.5 Guanine nucleotide binding protein (G 0004871 signal transducer activity 0007165 signal transduction Q5QPR5 49 5 ±2.1 9 ±0.1 13 ±0.1 protein), beta polypeptide 1 19 (2) 17 (15) 31 (27)

121 -3.1 50 -1.6 234 -1.7 0005524 ATP binding Hypothetical protein CCT4 (Chaperonin 0006457 protein folding Q53QP9 33 8 - 4 ±0.1 16 ±0.2 0000166 nucleotide binding containing TCP1, subunit 4) (Delta) 16 (1) 5 (3) 19 (12) 0051082 unfolded protein binding

0006865 amino acid transport 4F2 cell-surface antigen heavy chain 160 53 -2.5 190 -1.9 0005432 calcium:sodium 0006816 calcium ion transport (4F2hc) (Lymphocyte activation antigen 0009986 cell surface P08195 30 10 PC 3 ±0.2 13 ±0.3 antiporter activity 0016049 cell growth 4F2 large subunit) (4F2 heavy chain 0016021 integral to membrane 54 4 (2) 21 (13) 0005515 protein binding 0015827 tryptophan transport antigen) (CD98 antigen)

74 -2.9 115 -1.4 213 -1.1

P13639 Elongation factor 2 (EF-2) 28 6 ±0.9 8 ±0.1 14 ±0.2

16 (3) 10 (8) 22 (11)

0016023 cytoplasmic membrane- bound vesicle 0005768 endosome Transferrin receptor protein 1 (TfR1) 77 -3.4 86 -1.1 227 -1.0 0004998 transferrin receptor 0005576 extracellular region 0006879 iron ion homeostasis P02786 (TR) (TfR) (Trfr) (CD71 antigen) (T9) 25 5 ±1.5 6 ±0.2 13 ±0.1 activity 0005887 integral to plasma (p90) 28 (2) 9 (7) 23 (17) membrane 0016020 membrane

177 7.0 96 2.3 116 3.0 0003824 catalytic activity Phosphoglycerate mutase 1 (Brain) 0006096 glycolysis Q53G35 69 11 ±2.2 7 ±0.2 7 ±0.4 0016868 intramolecular variant (Fragment) 0008152 metabolism 73 (8) 9 (4) 17 (12) transferase activity, phosph 152 24.2 96 3.5 133 7.7 0005509 calcium ion binding

Q6FHB6 ANXA13 protein (Fragment) 56 10 - 6 ±0.6 9 ±2.1 0005544 calcium-dependent

35 (1) 7 (7) 16 (12) phospholipid binding

Bifunctional purine biosynthesis protein 0003937 IMP cyclohydrolase PURH [Includes: 219 2.5 17 -2.5 144 1.0 activity 0006139 nucleobase, nucleoside,

P31939 Phosphoribosylaminoimidazolecarboxa 39 14 ±0.6 1 - 8 ±0.1 0004643 nucleotide and nucl

mide formyltransferase (EC 2.1.2.3) 45 (7) 2 (1) 11 (2) phosphoribosylaminoimidazolecar (AICAR transformylase) boxamide for Peroxiredoxin-1 (EC 1.11.1.15) (Thioredoxin peroxidase 2) 155 2.2 97 2.3 127 4.0 (Thioredoxin-dependent peroxide 0008283 cell proliferation Q06830 55 11 ±0.7 7 ±0.3 9 ±0.6 reductase 2) (Proliferation-associated 0001501 skeletal development 60 (5) 10 (9) 14 (8) protein PAG) (Natural killer cell- enhancing factor A) (NKEF-A) 0005524 ATP binding 0016874 ligase activity Ubiquitin-activating enzyme E1 (A1S9T 157 6.2 29 3.2 182 2.4 0000166 nucleotide binding 0006512 ubiquitin cycle Q5JRR8 and BN75 temperature sensitivity 23 10 ±1.9 2 ±0.0 11 ±0.4 0004839 ubiquitin activating complementing) 33 (3) 4 (2) 24 (11) enzyme activity

Prominin-1 precursor (Prominin-like 209 -1.5 19 -1.3 136 -1.2 0005887 integral to plasma

O43490 protein 1) (Antigen AC133) (CD133 24 13 ±0.3 1 ±0.1 8 ±0.2 membrane

antigen) 71 (8) 2 (2) 16 (9)

199 -1.6 58 -1.7 102 -2.0 0005938 cell cortex 0005515 protein binding 0001525 angiogenesis P19338 Nucleolin (Protein C23) 21 13 ±0.9 3 ±0.3 7 ±0.4 0005730 nucleolus 0003723 RNA binding 34 (2) 6 (5) 11 (6)

ATP-dependent DNA helicase 2 subunit 1 (EC 3.6.1.-) (ATP-dependent DNA 0004003 ATP-dependent DNA 0006266 DNA ligation 0005624 membrane fraction helicase II 70 kDa subunit) (Lupus Ku 162 -1.4 85 -1.8 111 -1.9 helicase activity 0006303 double-strand break 0005634 nucleus P12956 autoantigen protein p70) (Ku70) (70 28 10 ±0.2 6 ±0.4 7 ±0.3 0003690 double-stranded DNA repair via nonhomologou 0005667 transcription factor kDa subunit of Ku antigen) (Thyroid- 30 (5) 7 (5) 10 (6) binding 0045893 positive regulation of complex lupus autoantigen) (TLAA) (CTC box- 0005515 protein binding transcription, DNA-d binding factor 75 Glucose-6-phosphate isomerase (EC 0005975 carbohydrate metabolism 5.3.1.9) (GPI) (Phosphoglucose 163 4.5 43 3.2 150 3.3 NAS:ProtInc

P06744 isomerase) (PGI) (Phosphohexose 36 10 ±1.7 3 ±0.2 10 ±0.3 0007599 hemostasis

isomerase) (PHI) (Neuroleukin) (NLK) 59 (4) 4 (4) 21 (17) 0006959 humoral immune (Sperm antigen 36) (SA-36) response

97 90 -1.7 160 -1.6 0005524 ATP binding Chaperonin containing TCP1, subunit 8 0006457 protein folding Q53HU0 29 7 PC 6 ±0.2 11 ±0.2 0000166 nucleotide binding (Theta) variant (Fragment) 11 7 (6) 22 (16) 0051082 unfolded protein binding

82 86 -1.4 177 -1.5 0000166 nucleotide binding Q5TCG3 OTTHUMP00000016816 24 7 PC 7 ±0.2 11 ±0.2 0003723 RNA binding 12 7 (6) 15 (7) Peptidyl-prolyl cis-trans isomerase A 143 2.1 70 2.7 129 3.5 0006457 protein folding (EC 5.2.1.8) (PPIase A) (Rotamase A) 0051082 unfolded protein binding P62937 70 10 ±0.3 5 ±0.4 8 ±0.7 0045069 regulation of viral (Cyclophilin A) (Cyclosporin A-binding 0046790 virion binding 66 (7) 9 (6) 16 (10) genome replication protein)

142 -3.3 46 -1.6 151 -1.4 0005524 ATP binding Chaperonin containing TCP1, subunit 3 0006457 protein folding Q59H77 31 11 ±0.7 4 ±0.1 10 ±0.1 0000166 nucleotide binding (Gamma) variant (Fragment) 28 (4) 5 (4) 18 (15) 0051082 unfolded protein binding

90 49 3.6 198 4.9 0016459 myosin 0005524 ATP binding Q5TEM5 Myosin VI 13 5 DC 3 ±1.2 12 ±0.9 0003774 motor activity 12 4 (2) 22 (17)

Heterogeneous nuclear 90 -9.9 85 -2.3 163 -1.4 0030530 heterogeneous nuclear ribonucleoprotein U (hnRNP U) 0003677 DNA binding 0006396 RNA processing Q00839 19 6 - 6 ±0.3 11 ±0.2 ribonucleoprotein com (Scaffold attachment factor A) (SAF-A) 0003723 RNA binding 31 (1) 10 (9) 20 (14) (p120) (pp120)

143 87 -1.9 107 -1.7 0005843 cytosolic small ribosomal 0003723 RNA binding 0006412 protein biosynthesis P23396 40S ribosomal protein S3 53 9 PC 6 ±0.2 7 ±0.3 subunit 0003735 structural constituent of

25 9 (6) 12 (8) ribosome

1-phosphatidylinositol-4,5-bisphosphate 111 2.1 46 2.4 176 2.6 phosphodiesterase beta 3 (EC 3.1.4.11) 0004629 phospholipase C activity Q01970 20 7 - 3 ±0.3 11 ±0.3 (Phosphoinositide phospholipase C) 25 (1) 3 (3) 16 (13) (Phospholipase C-beta-3) (PLC-beta-3)

28 3.6 94 2.9 209 5.7

Q8TCG3 TPMsk3 (Fragment) 34 2 - 5 ±0.5 15 ±1.2

6 (1) 7 (6) 19 (13)

Peroxiredoxin-6 (EC 1.11.1.15) (Antioxidant protein 2) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic 169 3.6 62 3.1 95 4.0 0016209 antioxidant activity 0009395 phospholipid catabolism 0005829 cytosol P30041 calcium-independent phospholipase A2) 61 11 ±0.5 4 ±0.2 6 ±0.7 0004623 phospholipase A2 0006979 response to oxidative

(EC 3.1.1.-) (aiPLA2) (Non-selenium 74 (6) 8 (4) 16 (11) activity stress glutathione peroxidase) (EC 1.11.1.7) (NSGPx) (24 kDa protein)

80 10.6 77 2.4 165 2.9

Q53EM5 Transketolase variant (Fragment) 27 5 ±5.0 5 ±0.1 10 ±0.3

35 (3) 9 (5) 27 (19)

0007030 Golgi organization and 41 70 2.4 209 4.6 0005737 cytoplasm 0005515 protein binding biogenesis Q9Y6Y8 SEC23-interacting protein (p125) 18 3 DC 5 ±0.3 13 ±0.9 0005793 ER-Golgi intermediate 0006886 intracellular protein 8 6 (4) 30 (18) compartment transport 88 1.2 54 1.8 172 1.8 0006886 intracellular protein Syntaxin-binding protein 2 (Unc-18 0030347 syntaxin-2 binding Q15833 30 6 ±0.1 4 ±0.2 10 ±0.2 transport homolog 2) (Unc-18B) (Unc18-2) 0030348 syntaxin-3 binding 28 (5) 6 (4) 21 (12)

PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal- 111 1.7 31 -1.3 163 1.6 0030165 PDZ domain binding 0015893 drug transport Q5T2W1 associated protein) (NaPi-Cap1) 40 8 ±0.3 2 ±0.8 10 ±0.2 0008022 protein C-terminus

(Na(+)/H(+) exchanger regulatory factor 14 (2) 3 (2) 18 (12) binding 3) (Sodium-hydrogen exchanger regulatory factor 3)

142 -5.8 63 -2.1 98 -2.3 0005887 integral to plasma 0000398 nuclear mRNA splicing, Heterogeneous nuclear 0003723 RNA binding NAS:HGNC P52272 27 10 - 4 ±0.3 7 ±0.2 membrane via spliceosome IC:HGNC ribonucleoprotein M (hnRNP M) 17 (1) 4 (3) 10 (4) 0005681 spliceosome complex

CCT7 protein (Hypothetical protein 142 -12.0 36 -1.8 122 -1.2 0005524 ATP binding 0006457 protein folding Q6FI26 CCT7) (Chaperonin containing TCP1, 34 10 - 2 ±0.1 8 ±0.1 0000166 nucleotide binding

subunit 7) (Eta) 19 (1) 2 (2) 15 (12) 0051082 unfolded protein binding

Rab GDP dissociation inhibitor beta 70 5.7 53 2.1 173 2.4 0005093 Rab GDP-dissociation (Rab GDI beta) (Guanosine 0009986 cell surface 0007165 signal transduction P50395 35 5 - 4 ±0.4 11 ±0.3 inhibitor activity diphosphate dissociation inhibitor 2) 0005737 cytoplasm 12 (1) 6 (2) 26 (17) (GDI-2)

0005525 GTP binding 76 -1.0 57 1.9 161 1.9 Eukaryotic translation elongation factor 0005737 cytoplasm 0000166 nucleotide binding 0006412 protein biosynthesis Q53HQ7 30 5 ±0.5 4 ±0.5 9 ±0.3 1 alpha 1 variant (Fragment) 0003746 translation elongation 0006414 translational elongation 138 (5) 6 (6) 35 (23) factor activity

Catenin delta-1 (p120 catenin) 83 1.4 26 1.1 182 -1.6 0005737 cytoplasm 0016337 cell-cell adhesion O60716 (p120(ctn)) (Cadherin-associated Src 19 6 - 2 - 11 ±0.2 0005634 nucleus substrate) (CAS) (p120(cas)) 8 (1) 2 (1) 19 (14)

65 25 -1.1 202 -1.7 T-complex protein 1 subunit alpha 0005829 cytosol 0051082 unfolded protein binding 0007021 tubulin folding P17987 37 5 PC 2 ±0.2 14 ±0.2 (TCP-1-alpha) (CCT-alpha) 13 2 (2) 24 (17)

Clathrin interactor 1 (Epsin-4) (Epsin- 117 -2.4 15 -1.2 159 -1.1 related protein) (EpsinR) (Enthoprotin) 0005794 Golgi apparatus 0005515 protein binding Q14677 23 9 ±0.8 1 ±0.0 10 ±0.2 (Clathrin-interacting protein localized in 22 (4) 2 (2) 19 (10) the trans-Golgi region) (Clint)

104 1.6 59 1.7 120 1.9 0005509 calcium ion binding

Q2M3Q4 EH-domain containing 1 29 8 ±0.3 4 ±0.6 8 ±0.4 0005525 GTP binding

17 (3) 5 (2) 11 (6) 0003924 GTPase activity 114 1.3 45 1.3 121 1.8 0006355 regulation of 0003723 RNA binding Q53SS8 Hypothetical protein PCBP1 42 8 ±0.4 3 ±0.1 7 ±0.3 transcription, DNA-dependent

36 (5) 3 (3) 14 (10) 0006350 transcription

Annexin A6 (Annexin VI) (Lipocortin VI) 149 1.4 21 1.2 110 -1.1 (P68) (P70) (Protein III) (Chromobindin- 0005515 protein binding P08133 29 9 ±0.3 2 ±0.0 7 ±0.1 20) (67 kDa calelectrin) (Calphobindin- 27 (6) 2 (2) 10 (8) II) (CPB-II)

166 3.0 45 2.8 65 3.1 0031404 chloride ion binding Chloride intracellular channel 1 variant 0016020 membrane 0006821 chloride transport Q53FB0 51 11 ±0.4 3 ±0.3 4 ±0.4 0005247 voltage-gated chloride (Fragment) 0006811 ion transport 94 (7) 7 (5) 12 (9) channel activity

46 -1.5 31 -1.1 199 -1.1

O94832 Myosin Id 16 3 ±0.4 2 ±0.0 13 ±0.2

7 (2) 2 (2) 18 (13)

92 2.9 46 1.2 131 1.7 0006457 protein folding 0005524 ATP binding Q2TAL4 Heat shock 70kDa protein 4 24 7 - 3 - 8 ±0.2 0006986 response to unfolded 0000166 nucleotide binding 10 (1) 3 (1) 21 (16) protein

0030041 actin filament polymerization 0030032 lamellipodium biogenesis Ras-related C3 botulinum toxin 152 4.4 45 1.1 71 2.0 0003924 GTPase activity 0048261 negative regulation of P63000 substrate 1 precursor (p21-Rac1) (Ras- 22 10 ±1.5 3 ±0.0 5 ±0.2 0005515 protein binding receptor mediated en like protein TC25) 88 (5) 5 (4) 7 (2) 0035025 positive regulation of Rho protein signal t TAS:

Spectrin alpha chain, brain (Spectrin, 21 30 1.8 216 3.3 0003779 actin binding 0005624 membrane fraction Q13813 non-erythroid alpha chain) (Alpha-II 9 2 DC 2 ±0.3 14 ±0.5 0005200 structural constituent of 0008091 spectrin spectrin) (Fodrin alpha chain) 2 3 (2) 20 (14) cytoskeleton

100 -1.8 63 -1.5 105 -1.3

P20073 Annexin A7 (Annexin VII) (Synexin) 26 7 ±0.3 5 ±0.2 7 ±0.1

21 (3) 5 (3) 13 (11)

123 -1.4 47 1.5 97 1.6 Ras-related protein Rab-5C (RAB5L) 0003924 GTPase activity P51148 54 8 ±0.5 3 ±0.1 6 ±0.1 (L1880) 47 (6) 6 (6) 9 (8)

0003677 DNA binding Interleukin enhancer-binding factor 3 0003725 double-stranded RNA (Nuclear factor of activated T-cells 90 0000279 M phase binding kDa) (NF-AT-90) (Double-stranded 38 109 -2.2 116 -1.4 0045892 negative regulation of 0005634 nucleus 0005515 protein binding Q12906 RNA-binding protein 76) (DRBP76) 18 3 PC 7 ±0.2 8 ±0.2 transcription, DNA-d 0016563 transcriptional activator (Translational control protein 80) 4 8 (4) 10 (4) 0045893 positive regulation of activity (TCP80) (Nuclear factor associated with transcription, DNA-d 0016564 transcriptional repressor dsRNA) (NFAR) ( activity

145 -1.2 25 -1.2 93 -1.5 N-ethylmaleimide-sensitive factor Q96IK3 52 10 ±0.4 2 ±0.2 6 ±0.1 attachment protein, alpha 25 (6) 3 (3) 7 (2)

134 10.3 13 3.0 115 2.4

Q6NUS1 PDCD6IP protein 24 8 - 1 - 7 ±0.4

14 (1) 1 (1) 9 (6)

0009055 electron carrier activity 0016853 isomerase activity CDNA FLJ45525 fis, clone 100 2.6 25 3.2 134 3.0 0003756 protein disulfide BRTHA2026311, highly similar to Q6ZSH5 26 6 ±0.5 2 - 8 ±0.3 isomerase activity Protein disulfide isomerase A6 (EC 24 (5) 2 (1) 17 (13) 0015035 protein disulfide 5.3.4.1) oxidoreductase activity

102 7.6 72 5.7 84 4.0 0005529 sugar binding Q59FR8 LGALS3 protein variant (Fragment) 33 7 ±1.6 5 ±1.1 5 ±0.6

304 (5) 10 (10) 30 (24)

92 -1.1 14 -1.0 148 -1.1 0005516 calmodulin binding Ras GTPase-activating-like protein 0005884 actin filament 0007165 signal transduction P46940 14 7 ±0.4 1 ±0.1 10 ±0.1 0005096 GTPase activator activity IQGAP1 (p195) 16 (2) 2 (2) 15 (8) 0005095 GTPase inhibitor activity

Solute carrier family 2, facilitated 82 -6.5 85 -2.3 87 -1.3 0005355 glucose transporter 0005975 carbohydrate metabolism

P11169 glucose transporter member 3 (Glucose 13 6 ±2.7 5 ±0.1 6 ±0.3 activity NAS:ProtInc

transporter type 3, brain) 17 (3) 9 (4) 13 (7) 0015758 glucose transport

82 46 -3.0 126 -1.7

Q5VLR4 Lung cancer oncogene 7 37 6 PC 3 ±0.7 8 ±0.2

18 4 (3) 15 (8)

0006886 intracellular protein 122 1.4 27 -1.6 102 -1.3 0030130 clathrin coat of trans- Adaptor-related protein complex 1, 0005488 binding transport Q8IY97 27 8 ±0.5 2 - 7 ±0.1 Golgi network vesicle gamma 1 subunit 0006461 protein complex 36 (4) 2 (1) 12 (10) assembly

0006944 membrane fusion Synaptosomal-associated protein 23 90 -9.1 35 1.2 50 2.3 0005886 plasma membrane 0005515 protein binding 0006892 post-Golgi vesicle- O00161 (SNAP-23) (Vesicle-membrane fusion 37 6 - 2 ±0.3 3 ±0.5 mediated transport protein SNAP-23) 17 (1) 3 (3) 5 (2) 0006903 vesicle targeting 99 -2.3 65 -1.3 85 1.1

Q6FG49 TACSTD1 protein 37 6 ±1.2 4 ±0.0 5 ±0.2

54 (2) 8 (2) 15 (10)

154 -2.7 43 -1.6 50 -2.2 0003735 structural constituent of 0042254 ribosome biogenesis and Ribosomal protein P0 variant 0005622 intracellular Q53HW2 46 8 ±0.8 3 ±0.6 3 ±0.2 ribosome assembly (Fragment) 0005840 ribosome 50 (5) 5 (4) 3 (3) 0006414 translational elongation

0009986 cell surface Protein disulfide-isomerase precursor 0005783 endoplasmic reticulum 0004656 procollagen-proline 4- 24 78 3.6 143 3.3 0018401 peptidyl-proline (EC 5.3.4.1) (PDI) (Prolyl 4-hydroxylase 0005793 ER-Golgi intermediate dioxygenase activity P07237 26 2 PC 5 ±0.3 10 ±0.9 hydroxylation to 4-hydroxy subunit beta) (Cellular thyroid hormone- compartment 0003756 protein disulfide 2 7 (5) 12 (8) binding protein) (p55) 0005576 extracellular region isomerase activity

118 8.0 15 3.0 111 3.7 0005524 ATP binding Galactokinase (EC 2.7.1.6) (Galactose 0005737 cytoplasm 0006012 galactose metabolism P51570 24 7 ±1.5 1 - 7 ±0.7 0004335 galactokinase activity kinase) 14 (2) 2 (1) 10 (4) 0005534 galactose binding

120 14 -1.9 109 -2.1 0005198 structural molecule 0005637 nuclear inner membrane P43243 Matrin-3 23 8 PC 1 - 7 ±0.3 activity

14 1 (1) 9 (7)

55 67 -1.8 121 -1.2 Chaperonin containing TCP1, subunit 2 Q14D36 33 5 PC 4 ±0.1 8 ±0.2 (Beta) 6 6 (4) 13 (11)

72 74 -1.8 94 -1.2 0005524 ATP binding Chaperonin containing TCP1, subunit 0006457 protein folding Q3KP28 29 5 PC 5 ±0.1 6 ±0.1 0000166 nucleotide binding 6A (Zeta 1) 16 5 (4) 9 (5) 0051082 unfolded protein binding

27 49 3.0 158 2.6 0006888 ER to Golgi vesicle- Protein transport protein Sec24A 0030127 COPII vesicle coat O95486 13 2 DC 3 ±1.0 10 ±0.5 mediated transport (SEC24-related protein A) (Fragment) 3 5 (3) 15 (10)

Serpin peptidase inhibitor, clade H 91 1.3 49 1.4 93 1.9

Q6NSJ6 (Heat shock protein 47), member 1, 29 6 ±0.1 3 ±0.1 6 ±0.4

(Collagen binding protein 1) 20 (4) 5 (5) 13 (9)

48 -6.0 18 -1.1 165 -1.2 Q9BWC 0005488 binding JUP protein (Fragment) 16 4 - 1 - 9 ±0.1 4 6 (1) 1 (1) 18 (12) Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and 161 4.4 14 1.5 56 1.2 0043086 negative regulation of neddylation-dissociated protein 1) (p120 0000151 ubiquitin ligase complex 0005515 protein binding Q86VP6 14 11 ±1.3 1 - 4 ±0.2 enzyme activity CAND1) (TBP-interacting protein 24 (5) 1 (1) 5 (4) 0016567 protein ubiquitination TIP120A) (TBP-interacting protein of 120 kDa A)

95 -6.9 43 -1.8 92 -1.9 0004872 receptor activity Ribosomal protein SA (Laminin receptor 0005622 intracellular 0006412 protein biosynthesis Q6IPD2 40 5 - 3 ±0.1 5 ±0.3 0003735 structural constituent of 1) (Ribosomal protein SA, 67kDa) 0015935 small ribosomal subunit 18 (1) 6 (4) 13 (7) ribosome

0030036 actin cytoskeleton 98 14.0 33 4.8 99 3.9 organization and biogenesis Cofilin-1 (Cofilin, non-muscle isoform) 0005737 cytoplasm 0005515 protein binding P23528 62 5 ±4.6 2 - 6 ±1.0 0006916 anti-apoptosis (18 kDa phosphoprotein) (p18) 0005634 nucleus 55 (5) 3 (1) 14 (8) 0007266 Rho protein signal transduction

60 81 2.4 88 2.9

Q5BJF0 SEC13-like 1 (S. cerevisiae) 35 5 DC 5 ±0.5 6 ±0.6

9 9 (8) 15 (10)

85 46 3.1 94 3.6 0030154 cell differentiation Q6IBG2 NDRG1 protein 34 6 DC 3 ±0.1 5 ±0.9

11 3 (2) 11 (7)

96 1.3 54 1.5 73 3.2 Myosin, light polypeptide 6, alkali, 0005509 calcium ion binding Q561V9 58 7 ±0.2 4 ±0.1 5 ±0.6 smooth muscle and non-muscle 32 (6) 4 (3) 10 (7)

131 1.5 14 1.2 77 1.2 0007264 small GTPase mediated RAP1B, member of RAS oncogene 0005622 intracellular 0005525 GTP binding Q5TZR4 48 8 ±0.2 1 ±0.0 5 ±0.2 signal transduction family 0016020 membrane 0000166 nucleotide binding 114 (7) 3 (2) 8 (5)

Myristoylated alanine-rich C-kinase 70 -1.3 43 1.2 108 1.7 substrate (MARCKS) (Protein kinase C 0015629 actin cytoskeleton 0051015 actin filament binding P29966 33 4 ±0.1 3 ±0.0 6 ±0.2 substrate, 80 kDa protein, light chain) 0005516 calmodulin binding 16 (2) 3 (2) 11 (8) (PKCSL) (80K-L protein)

25 23 -1.2 173 1.0 0004289 subtilase activity 0006508 proteolysis Q5VZU9 Tripeptidyl peptidase II 14 2 PC 2 ±0.0 11 ±0.2

2 2 (2) 17 (12)

71 73 -3.7 77 -2.9 0005622 intracellular Q5JR94 Ribosomal protein S8 30 4 PC 4 ±0.8 5 ±0.5

16 5 (3) 11 (6) 2',3'-cyclic-nucleotide 3'- 76 -1.9 31 -1.0 111 1.9 0004113 2',3'-cyclic-nucleotide 3'- 0007268 synaptic transmission P09543 phosphodiesterase (EC 3.1.4.37) (CNP) 28 4 ±0.1 2 ±0.1 7 ±0.6 phosphodiesteras

(CNPase) 18 (3) 3 (2) 12 (9)

79 -3.4 31 -2.5 101 -2.2 0005488 binding 0015031 protein transport Q54AC4 Gamma1-COP 21 6 - 2 - 6 ±0.2

11 (1) 2 (1) 9 (7)

71 -2.2 42 -3.6 91 -1.6 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q6NXR8 Ribosomal protein S3A 38 5 - 3 ±1.1 6 ±0.3 ribosome 0005840 ribosome 12 (1) 3 (3) 7 (7)

98 -20.8 46 -3.2 54 -2.8 0005842 cytosolic large ribosomal 0003723 RNA binding 60S acidic ribosomal protein P2 (NY- 0006412 protein biosynthesis P05387 48 6 ±0.7 3 ±0.4 3 ±0.2 subunit 0003735 structural constituent of REN-44 antigen) 27 (2) 3 (2) 7 (3) ribosome

97 -2.2 29 1.4 72 1.2 0031404 chloride ion binding Chloride intracellular channel 4 (CLIC4 0016020 membrane 0006821 chloride transport Q5VSX5 39 6 ±0.8 2 - 4 ±0.3 0005247 voltage-gated chloride protein) 0006811 ion transport 40 (6) 2 (1) 6 (3) channel activity

70 -2.8 29 -1.4 99 -1.0 0005853 eukaryotic translation 0003746 translation elongation Eukaryotic translation elongation factor 0006414 translational elongation Q53YD7 16 5 ±0.5 2 ±0.0 6 ±0.1 elongation factor 1 factor activity 1 gamma (GIG35) (EEF1G protein) 18 (2) 3 (3) 9 (6)

52 32 5.4 114 4.6 Sushi domain-containing protein 2 Q9UGT4 14 3 DC 2 ±1.5 7 ±1.0 precursor 17 3 (3) 12 (5)

84 -9.4 26 -3.0 88 -2.2 0003723 RNA binding 0005622 intracellular 0006412 protein biosynthesis Q5SUJ3 Ribosomal protein S18 43 7 ±3.4 2 ±0.1 6 ±0.3 0003735 structural constituent of 0005840 ribosome 22 (2) 2 (2) 8 (7) ribosome

Malate dehydrogenase, cytoplasmic 107 5.8 29 2.7 61 3.9 0005829 cytosol 0004470 malic enzyme activity P40925 (EC 1.1.1.37) (Cytosolic malate 34 7 ±4.0 2 ±0.4 4 ±0.9

dehydrogenase) 31 (6) 2 (2) 6 (3)

0050661 NADP binding 82 2.9 42 1.3 72 2.8 0009051 pentose-phosphate 6-phosphogluconate dehydrogenase, 0016491 oxidoreductase activity Q4VXH6 16 6 ±0.2 3 ±0.2 5 ±0.3 shunt, oxidative branch decarboxylating 0004616 phosphogluconate 23 (2) 4 (2) 8 (4) dehydrogenase (decarboxyla

0003924 GTPase activity 115 2.2 26 1.1 54 1.2 0005886 plasma membrane 0005515 protein binding P84077 ADP-ribosylation factor 1 50 7 ±0.7 2 ±0.1 4 ±0.1 0005057 receptor signaling 37 (3) 3 (3) 6 (2) protein activity Hsc70-interacting protein (Hip) (Suppression of tumorigenicity protein 66 3.3 67 3.2 60 3.7 13) (Putative tumor suppressor ST13) 0005737 cytoplasm 0030674 protein binding, bridging 0006457 protein folding P50502 16 4 ±1.0 4 ±0.3 4 ±0.9 (Protein FAM10A1) (Progesterone 13 (3) 6 (5) 10 (8) receptor-associated p48 protein) (NY- REN-33 antigen)

81 11 3.3 98 2.6 Aldehyde dehydrogenase 1 family, 0016491 oxidoreductase activity 0008152 metabolism Q5SYR1 35 6 DC 1 - 6 ±0.4 member A1 (Fragment) 11 1 (1) 9 (8)

X-ray repair complementing defective 35 59 -1.6 95 -2.0

Q0Z7V0 repair in Chinese hamster cells 5 18 3 PC 4 ±0.4 6 ±0.3

(Double-strand-break rejoining 3 5 (4) 9 (4)

Acidic leucine-rich nuclear phosphoprotein 32 family member A 0005737 cytoplasm 0007242 intracellular signaling (Potent heat-stable protein phosphatase 107 1.7 18 1.4 63 3.6 0005783 endoplasmic reticulum 0005515 protein binding cascade P39687 2A inhibitor I1PP2A) (Acidic nuclear 25 7 ±0.5 1 - 4 ±1.4 0005634 nucleus 0006913 nucleocytoplasmic phosphoprotein pp32) (Leucine-rich 50 (4) 1 (1) 7 (4) 0048471 perinuclear region transport acidic nuclear protein) (Lanp) (Putative HLA-DR-associated

112 31 4.7 44 5.1 0016339 calcium-dependent cell- Mucin and cadherin-like protein 0016021 integral to membrane 0005509 calcium ion binding Q9HBB8 14 7 DC 2 - 3 ±0.7 cell adhesion precursor (Mu-protocadherin) 0016020 membrane 32 2 (1) 5 (4) 0007155 cell adhesion

0016209 antioxidant activity 0042632 cholesterol homeostasis 0050749 apolipoprotein E receptor 0008015 circulation 86 -3.9 26 1.4 71 1.6 binding 0007010 cytoskeleton 0005737 cytoplasm P02649 Apolipoprotein E precursor (Apo-E) 27 6 ±1.0 2 ±0.1 4 ±0.5 0001540 beta-amyloid binding organization and biogenesis 0005576 extracellular region 22 (3) 3 (3) 7 (4) 0008201 heparin binding 0006917 induction of apoptosis 0005543 phospholipid binding 0046907 intracellular transport

Eukaryotic translation initiation factor 3 13 35 -2.1 131 -1.7 0005852 eukaryotic translation 0003743 translation initiation 0006413 translational initiation P55884 subunit 9 (eIF-3 eta) (eIF3 p116) (eIF3 14 1 PC 3 ±0.2 8 ±0.3 initiation factor 3 factor activity

p110) (eIF3b) (Prt1 homolog) (hPrt1) 1 3 (3) 9 (6)

53 30 -1.9 95 -1.5 0030529 ribonucleoprotein 0006355 regulation of Heterogeneous nuclear 0003723 RNA binding Q5EC54 24 3 PC 2 - 6 ±0.3 complex transcription, DNA-dependent ribonucleoprotein K transcript variant 17 3 (1) 12 (8) 0006350 transcription

Guanine nucleotide-binding protein 92 1.3 31 2.0 55 3.2 subunit alpha-11 (G alpha-11) (Guanine 0005737 cytoplasm 0003924 GTPase activity 0007165 signal transduction P29992 27 6 ±0.4 2 ±0.3 3 ±0.6 nucleotide-binding protein G(y) subunit 0005886 plasma membrane 29 (5) 5 (5) 7 (5) alpha)

53 26 -2.0 99 -1.2

Q96AU2 HNRPF protein 18 4 PC 2 - 6 ±0.5

14 2 (1) 9 (5) 105 -1.2 13 -1.4 58 -1.8 0005770 late endosome 0003924 GTPase activity 0006897 endocytosis P51149 Ras-related protein Rab-7 47 7 ±0.3 1 - 4 ±0.3 0005764 lysosome 57 (5) 1 (1) 5 (3)

0030036 actin cytoskeleton organization and biogenesis 0043123 positive regulation of I- 73 -1.1 58 1.5 45 1.0 0003924 GTPase activity Transforming protein RhoA precursor kappaB kinase/NF-k P61586 55 5 ±0.6 4 ±0.1 3 ±0.1 0005515 protein binding (H12) 0042346 positive regulation of NF- 24 (4) 6 (5) 5 (5) 0004871 signal transducer activity kappaB import int 0007266 Rho protein s

0005524 ATP binding 0000166 nucleotide binding 0004674 protein serine/threonine 32 2.3 30 1.2 109 1.2 0006468 protein amino acid Serine/threonine kinase 24 (STE20 kinase activity Q5T5B3 18 2 - 2 - 7 ±0.1 phosphorylation homolog, yeast) 0004713 protein-tyrosine kinase 7 (1) 2 (1) 12 (10) activity 0016740 transferase activity

0005524 ATP binding 0015031 protein transport 0005525 GTP binding 97 1.5 14 1.3 59 1.6 0006355 regulation of RAB11B, member RAS oncogene 0005622 intracellular 0000166 nucleotide binding Q5U0I1 38 7 ±0.2 1 - 4 ±0.4 transcription, DNA-dependent family 0016020 membrane 0008134 transcription factor 50 (6) 1 (1) 6 (5) 0007264 small GTPase mediated binding signal transduction

42 24 1.5 104 2.2 0003777 microtubule motor 0007018 microtubule-based Kinesin heavy chain (Ubiquitous kinesin 0005871 kinesin complex P33176 15 3 DC 2 ±0.7 7 ±0.4 activity movement heavy chain) (UKHC) 5 3 (2) 8 (8)

28 -2.5 27 -1.1 114 1.3 N-acetylated alpha-linked acidic 0008233 peptidase activity 0006508 proteolysis Q4VAM9 15 2 - 2 ±0.1 7 ±0.2 dipeptidase 2 6 (1) 2 (2) 11 (9)

Heterogeneous nuclear 54 -1.7 28 -2.8 87 -1.9 0000398 nuclear mRNA splicing, 0005681 spliceosome complex 0042802 identical protein binding P07910 ribonucleoproteins C1/C2 (hnRNP C1 / 27 3 ±0.4 2 ±0.0 6 ±0.4 via spliceosome IC:HGNC 0003723 RNA binding NAS:HGNC hnRNP C2) 29 (3) 2 (2) 8 (7) 0008380 RNA splicing

0005509 calcium ion binding 35 2.0 48 1.9 85 3.0 0007186 G-protein coupled 0005737 cytoplasm 0031997 N-terminal myristoylation P62158 Calmodulin (CaM) 32 2 ±0.5 3 ±0.1 5 ±0.5 receptor protein signalin 0005886 plasma membrane domain binding 25 (2) 5 (3) 19 (15) 0005515 protein binding

0005544 calcium-dependent 67 -3.1 30 1.2 71 -1.4 phospholipid binding 0006629 lipid metabolism

Q99829 Copine-1 (Copine I) 13 5 - 2 ±0.1 5 ±0.2 0001786 phosphatidylserine 0016192 vesicle-mediated

19 (1) 2 (2) 10 (7) binding transport 0005215 transporter activity

98 6.4 34 1.8 133 3.0 0009055 electron carrier activity D-3-phosphoglycerate dehydrogenase 0007420 brain development O43175 28 6 ±1.3 2 - 9 ±0.4 0004617 phosphoglycerate (EC 1.1.1.95) (3-PGDH) 16 (2) 2 (1) 12 (8) dehydrogenase activity 30 -1.9 51 1.3 85 1.3 0005634 nucleus 0006334 nucleosome assembly Q6FHZ5 SET protein 29 2 ±0.0 3 ±0.3 6 ±0.4

19 (2) 7 (4) 7 (3)

Vitronectin precursor (Serum-spreading 32 3.7 64 1.6 69 1.2 0005576 extracellular region 0005515 protein binding 0007155 cell adhesion P04004 factor) (S-protein) (V75) [Contains: 11 2 ±1.5 4 ±0.3 4 ±0.4 0005615 extracellular space 0006955 immune response Vitronectin V65 subunit 8 (2) 7 (3) 8 (4)

0051059 NF-kappaB binding 0051092 activation of NF-kappaB 0046982 protein transcription factor 0005813 centrosome heterodimerization activity 0006916 anti-apoptosis Nucleophosmin (NPM) (Nucleolar 92 -1.4 21 -2.6 46 -1.7 0005737 cytoplasm 0042803 protein 0007569 cell aging P06748 phosphoprotein B23) (Numatrin) 28 5 ±0.3 1 - 3 ±0.3 0005730 nucleolus homodimerization activity 0007098 centrosome cycle (Nucleolar protein NO38) 23 (3) 1 (1) 9 (6) 0005634 nucleus 0003723 RNA binding 0006886 intracellular protein

0030957 Tat protein binding transport TAS:

74 5.1 26 6.9 58 7.3 0008171 O-methyltransferase 0016021 integral to membrane Q6ICE6 COMT protein 25 4 ±1.4 2 - 3 ±2.0 activity 0016020 membrane 26 (3) 2 (1) 3 (3) 0016740 transferase activity

77 -3.2 23 -3.3 53 -1.7 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q5VVV2 Ribosomal protein L12 54 5 ±0.4 2 ±0.6 3 ±0.4 ribosome 0005840 ribosome 41 (5) 2 (2) 9 (7)

47 42 -2.2 62 -1.8 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q6NZ55 Ribosomal protein L13 29 4 PC 3 ±0.6 5 ±0.3 ribosome 0005840 ribosome 6 3 (3) 5 (5)

101 -1.6 11 -1.2 39 1.2

Q5JWU6 OTTHUMP00000031614 44 7 ±0.3 1 - 3 -

46 (5) 1 (1) 3 (1)

0007507 heart development 0006880 intracellular sequestering of iron ion 69 4.3 28 1.7 53 1.7 0005246 calcium channel 0005737 cytoplasm 0007517 muscle development P30626 Sorcin (22 kDa protein) (CP-22) (V19) 37 5 ±0.6 2 ±0.3 4 ±0.3 regulator activity 0001508 regulation of action 36 (2) 3 (3) 7 (5) 0005102 receptor binding potential 0008016 regulation of heart contra

39 -1.0 16 -2.3 96 -1.5 0030529 ribonucleoprotein Heterogeneous nuclear 0003723 RNA binding P51991 23 3 - 1 ±0.2 6 ±0.2 complex ribonucleoprotein A3 (hnRNP A3) 11 (1) 2 (2) 6 (3)

67 -2.1 13 -1.8 70 1.1 0008565 protein transporter 0006886 intracellular protein 0016020 membrane Q53YE2 Syntaxin 3A 28 4 ±0.9 1 ±0.5 5 ±0.2 activity transport

30 (3) 2 (2) 10 (10) 0003735 structural constituent of 74 26 -2.0 48 -1.6 0005622 intracellular ribosome 0006412 protein biosynthesis Q3KQU0 RPL7 protein 26 6 PC 2 - 3 ±0.1 0015934 large ribosomal subunit 0030528 transcription regulator 12 3 (1) 8 (4) activity

0003999 adenine Adenine phosphoribosyltransferase 101 5.1 12 2.2 33 2.5 phosphoribosyltransferase activity 0006168 adenine salvage Q3KP55 (Adenine phosphoribosyltransferase, 55 7 ±1.2 1 - 2 - 0016757 transferase activity, 0009116 nucleoside metabolism isoform a) 37 (4) 1 (1) 2 (1) transferring glycosyl

0005355 glucose transporter Solute carrier family 2 (Facilitated 27 -1.2 71 -2.1 47 1.2 0016021 integral to membrane activity 0008643 carbohydrate transport Q59GX2 glucose transporter), member 1 variant 11 2 - 4 ±0.3 3 ±0.1 0016020 membrane 0005351 sugar porter activity (Fragment) 3 (1) 6 (4) 4 (4) 0005215 transporter activity

16 -1.2 14 -3.1 113 -1.8 0003677 DNA binding 0005622 intracellular 0006412 protein biosynthesis Q9HBB3 DNA-binding protein TAXREB107 29 1 - 1 - 7 ±0.3 0003735 structural constituent of 0005840 ribosome 2 (1) 1 (1) 8 (7) ribosome

51 25 2.7 65 2.3 Puromycin-sensitive aminopeptidase 0005829 cytosol 0004177 aminopeptidase activity P55786 12 3 DC 2 ±0.1 4 ±0.3 (EC 3.4.11.-) (PSA) 6 2 (2) 5 (5)

81 2.0 16 5.0 43 4.8 Aminoacylase-1 (EC 3.5.1.14) (N-acyl- 0005829 cytosol 0004046 aminoacylase activity Q03154 28 6 ±0.4 1 - 3 ±1.3 L-amino-acid amidohydrolase) (ACY-1) 16 (2) 1 (1) 4 (4)

Protein disulfide-isomerase A4 52 19 1.3 67 1.7 0005788 endoplasmic reticulum 0009306 protein secretion P13667 precursor (EC 5.3.4.1) (Protein ERp-72) 17 4 DC 1 - 5 - lumen

(ERp72) 6 1 (1) 5 (1)

0004364 glutathione transferase 58 3.9 29 3.5 48 3.1 Glutathione transferase omega-1 (EC 0005737 cytoplasm activity P78417 19 4 ±0.3 2 ±1.5 3 ±0.6 2.5.1.18) (GSTO 1-1) 0016656 monodehydroascorbate 28 (3) 2 (2) 5 (4) reductase (NADH) activity

42 3.1 34 2.7 57 3.5 Vesicle amine transport protein 1 0016491 oxidoreductase activity Q5BKZ7 18 3 ±0.9 2 ±0.3 3 ±0.6 homolog (T californica) 0008270 zinc ion binding 8 (2) 3 (3) 5 (4)

48 37 -2.9 48 -1.7 0003735 structural constituent of RPL14 protein (Ribosomal protein L14 0005622 intracellular 0006412 protein biosynthesis Q6IPH7 18 3 PC 2 ±0.0 3 ±0.4 ribosome variant) 0005840 ribosome 9 2 (2) 5 (3)

55 23 -2.4 53 -2.3 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q96DV6 Ribosomal protein S6 29 4 PC 2 - 4 ±0.4 ribosome 0005840 ribosome 8 2 (1) 6 (4) Leukocyte elastase inhibitor (LEI) 79 1.2 16 2.7 35 5.0 0004867 serine-type 0005737 cytoplasm P30740 (Serpin B1) (Monocyte/neutrophil 20 6 ±0.4 1 - 2 ±1.9 endopeptidase inhibitor activity

elastase inhibitor) (M/NEI) (EI) 13 (3) 1 (1) 3 (2)

26 29 -1.0 75 -1.1 Aldehyde dehydrogenase 16 family, 0016491 oxidoreductase activity 0008152 metabolism Q8IZ83 13 2 PC 2 - 5 ±0.2 member A1 2 2 (1) 6 (4)

57 -3.3 29 -1.3 42 -1.7

P62750 60S ribosomal protein L23a 30 4 - 2 ±0.5 3 ±0.4

26 (1) 3 (2) 4 (2)

53 2.5 31 2.8 44 4.3 0005737 cytoplasm 0005515 protein binding 0005975 carbohydrate metabolism P37837 Transaldolase (EC 2.2.1.2) 13 4 ±1.4 2 ±0.2 3 ±1.1 0004801 transaldolase activity 9 (2) 3 (2) 6 (4)

63 13 1.9 52 3.0 Kinesin light chain 4 (KLC 4) (Kinesin- Q9NSK0 12 4 DC 1 - 3 ±0.9 like protein 8) 6 1 (1) 5 (3)

Vesicular integral-membrane protein 51 3.3 36 1.5 40 1.0 0005793 ER-Golgi intermediate

Q12907 VIP36 precursor (GP36b glycoprotein) 29 4 ±0.1 3 ±0.2 3 ±0.2 compartment

(Lectin, mannose-binding 2) 20 (2) 4 (2) 6 (3)

66 1.6 24 1.0 35 -1.3 0005694 chromosome 0007001 chromosome 0003677 DNA binding Q6FGB8 Histone H4 (Fragment) 41 5 ±0.4 2 ±0.2 3 ±0.1 0000786 nucleosome organization and biogenesis (sen

29 (4) 2 (2) 4 (3) 0005634 nucleus 0006334 nucleosome assembly

0003677 DNA binding 0003725 double-stranded RNA Interleukin enhancer-binding factor 2 44 32 -2.0 50 -1.9 binding 0045893 positive regulation of 0005730 nucleolus Q12905 (Nuclear factor of activated T-cells 45 30 3 PC 2 - 3 ±0.1 0005515 protein binding transcription, DNA-d 0005634 nucleus kDa) 4 2 (1) 4 (3) 0003702 RNA polymerase II transcription factor acti

0005789 endoplasmic reticulum ERGIC-53 protein precursor (ER-Golgi membrane 0007596 blood coagulation intermediate compartment 53 kDa 39 11 1.3 75 1.2 0005793 ER-Golgi intermediate 0005537 mannose binding 0006888 ER to Golgi vesicle- P49257 protein) (Lectin, mannose-binding 1) 21 3 DC 1 - 4 ±0.2 compartment 0051082 unfolded protein binding mediated transport (Gp58) (Intracellular mannose-specific 14 1 (1) 6 (3) 0000139 Golgi membrane 0006457 protein folding lectin MR60) 0016021 integral to membrane

47 -3.2 37 -1.2 37 1.6 0005853 eukaryotic translation 0005515 protein binding 0006414 translational elongation P24534 Elongation factor 1-beta (EF-1-beta) 28 3 ±0.6 2 - 2 ±0.5 elongation factor 1 0003746 translation elongation

23 (2) 2 (1) 4 (2) factor activity 75 1.1 16 -1.7 30 -1.7 0030662 coated vesicle 0006886 intracellular protein Coatomer protein complex, subunit zeta Q53FU3 33 4 ±0.4 1 ±0.1 2 ±0.1 membrane transport 1 variant (Fragment) 17 (4) 2 (2) 3 (2) 0006810 transport

Cation-dependent mannose-6- 0009986 cell surface 0008333 endosome to lysosome phosphate receptor precursor (CD Man- 56 -2.4 18 -3.0 47 -1.7 0004888 transmembrane receptor 0005768 endosome transport P20645 6-P receptor) (CD-MPR) (46 kDa 16 3 ±0.9 1 - 3 ±0.5 activity 0005887 integral to plasma 0006898 receptor mediated mannose 6-phosphate receptor) (MPR 25 (2) 4 (1) 7 (3) membrane endocytosis 46)

29 12 2.5 79 2.2 Epithelial protein lost in neoplasm beta 0046872 metal ion binding Q59FE8 14 2 DC 1 - 5 ±0.3 variant (Fragment) 0008270 zinc ion binding 4 1 (1) 8 (5)

91 -28.8 13 -3.5 15 -4.9 0005843 cytosolic small ribosomal 0005515 protein binding 0006412 protein biosynthesis P62277 40S ribosomal protein S13 40 6 - 1 - 1 - subunit 0003735 structural constituent of

18 (1) 1 (1) 1 (1) ribosome

43 25 -2.6 48 -2.5

P62906 60S ribosomal protein L10a (CSA-19) 21 3 PC 2 ±0.1 3 ±0.1

5 2 (2) 4 (4)

0045892 negative regulation of transcription, DNA-d 0030490 processing of 20S pre- 28 -9.4 33 -1.7 52 -1.7 0005843 cytosolic small ribosomal 0003723 RNA binding rRNA P62263 40S ribosomal protein S14 22 2 - 2 - 3 ±0.5 subunit 0003735 structural constituent of 0006412 protein biosynthesis 5 (1) 2 (1) 5 (2) ribosome 0000028 ribosomal small subunit assembly and mainte K

Protein disulfide-isomerase A3 0004197 cysteine-type 0006606 protein import into precursor (EC 5.3.4.1) (Disulfide 15 39 2.4 58 2.3 endopeptidase activity 0005783 endoplasmic reticulum nucleus P30101 isomerase ER-60) (ERp60) (58 kDa 15 1 DC 3 - 4 ±0.7 0004629 phospholipase C activity 0006621 protein retention in ER microsomal protein) (p58) (ERp57) (58 1 4 (1) 7 (3) 0003756 protein disulfide 0007165 signal transduction kDa glucose-regulated protein) isomerase activity Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 26 1.1 16 3.0 68 4.4 0003824 catalytic activity 0006091 generation of precursor 2.4.2.19) (Quinolinate Q15274 20 2 ±0.1 1 - 4 ±0.5 0004514 nicotinate-nucleotide metabolites and energy phosphoribosyltransferase 5 (2) 1 (1) 10 (8) diphosphorylase (carb 0007268 synaptic transmission [decarboxylating]) (QAPRTase) (QPRTase) Ubiquitin-conjugating enzyme E2-25 kDa (EC 6.3.2.19) (Ubiquitin-protein 66 -1.4 11 1.9 34 1.6

P61086 ligase) (Ubiquitin carrier protein) 33 4 ±0.5 1 - 2 ±0.5

(E2(25K)) (Huntingtin-interacting protein 14 (3) 1 (1) 3 (2) 2) (HIP-2)

29 31 -5.3 51 -1.6

P62888 60S ribosomal protein L30 41 2 PC 2 - 3 ±0.2

9 2 (1) 7 (6) Nascent polypeptide-associated 60 -1.3 16 1.2 33 -1.3 0005737 cytoplasm 0006412 protein biosynthesis Q13765 complex subunit alpha (NAC-alpha) 25 4 ±0.2 1 - 2 ±0.2 0005854 nascent polypeptide-

(Alpha-NAC) (Hom s 2.02) 21 (2) 1 (1) 2 (2) associated complex

0008283 cell proliferation 0007166 cell surface receptor linked signal transdu Macrophage migration inhibitory factor 50 3.9 30 4.7 29 3.2 0043066 negative regulation of (MIF) (Phenylpyruvate tautomerase) 0005576 extracellular region 0005125 cytokine activity P14174 35 3 ±2.7 2 ±1.0 2 ±0.3 apoptosis (EC 5.3.2.1) (Glycosylation-inhibiting 0005515 protein binding 34 (2) 4 (4) 9 (6) 0001516 prostaglandin factor) (GIF) biosynthesis 0043030 P

38 -8.8 34 -1.3 33 -1.8 0005842 cytosolic large ribosomal 0003723 RNA binding 0006412 protein biosynthesis Q07020 60S ribosomal protein L18 19 2 ±0.2 2 ±0.3 2 ±0.1 subunit 0003735 structural constituent of

24 (2) 3 (2) 2 (2) ribosome

Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) 34 4.1 18 2.3 52 4.6

Q9H444 (CHMP4b) (Vacuolar protein sorting 7- 18 2 ±0.6 1 - 3 ±1.2

2) (SNF7-2) (hSnf7-2) (SNF7 homolog 7 (2) 1 (1) 4 (3) associated with Alix 1) (hVps32)

Farnesyl diphosphate synthase 29 37 3.8 38 3.2 (Farnesyl pyrophosphate synthetase, 0016740 transferase activity 0008299 isoprenoid biosynthesis Q96G29 10 2 DC 2 ±0.3 2 ±1.1 dimethylallyltranstransferase, 5 4 (3) 4 (3) geranyltranstransferase)

Endoplasmic reticulum-Golgi 59 5.1 11 1.8 32 2.3 0005793 ER-Golgi intermediate 0006888 ER to Golgi vesicle- intermediate compartment protein 1 0005515 protein binding Q969X5 23 4 ±1.3 1 - 2 ±0.5 compartment mediated transport (ER-Golgi intermediate compartment 32 9 (2) 1 (1) 2 (2) kDa protein) (ERGIC-32)

0005524 ATP binding 0008026 ATP-dependent helicase 21 17 -2.3 60 -1.9 activity DEAD/H (Asp-Glu-Ala-Asp/His) box Q59GX6 6 2 PC 1 - 4 ±0.5 0016787 hydrolase activity polypeptide 3 variant (Fragment) 2 1 (1) 4 (4) 0003676 nucleic acid binding 0000166 nucleotide binding

RNA binding protein (Autoantigenic, hnRNP-associated with lethal yellow) 57 1.4 15 -2.0 27 -1.2 long isoform variant (RNA binding 0003676 nucleic acid binding Q53GL6 24 4 ±0.2 1 - 2 ±0.3 protein, autoantigenic) (HnRNP- 0000166 nucleotide binding 12 (2) 1 (1) 2 (2) associated with lethal yellow homolog (Mouse)) (Fragment)

Cytochrome b5 type B precursor 30 1.5 11 -1.4 12 -1.5

O43169 (Cytochrome b5 outer mitochondrial 21 2 - 1 - 1 -

membrane isoform) 8 (1) 1 (1) 1 (1)

39 13 -1.9 45 -2.2 0003676 nucleic acid binding 0005622 intracellular 0006412 protein biosynthesis Q567Q7 Ribosomal protein L8 21 3 PC 1 - 3 ±0.2 0003735 structural constituent of 0005840 ribosome 8 1 (1) 7 (5) ribosome 56 1.2 15 1.8 26 4.2 Calcium-binding protein 39 (Protein 0005515 protein binding Q9Y376 23 4 ±0.2 1 - 2 ±0.7 Mo25) 24 (3) 1 (1) 2 (2)

Sepiapterin reductase (7,8- 65 1.9 15 1.6 16 2.4 0016491 oxidoreductase activity 0008152 metabolism

Q53GI9 dihydrobiopterin:NADP+ 24 4 ±0.2 1 - 1 ±0.3 0004757 sepiapterin reductase 0006729 tetrahydrobiopterin

oxidoreductase) variant (Fragment) 22 (2) 1 (1) 2 (2) activity biosynthesis

28 2.9 29 1.1 39 1.7 0005834 heterotrimeric G-protein 0007186 G-protein coupled G-protein gamma-12 subunit variant 0004871 signal transducer activity Q53GD1 44 2 - 2 ±0.1 2 ±0.1 complex receptor protein signalin (Fragment) 5 (1) 3 (2) 5 (3)

42 25 -2.9 28 -2.4 0005843 cytosolic small ribosomal 0003735 structural constituent of 0006412 protein biosynthesis P62851 40S ribosomal protein S25 24 3 PC 2 ±0.5 2 - subunit ribosome

10 3 (3) 3 (1)

31 31 7.6 32 6.0 0004364 glutathione transferase Glutathione S-transferase A1 (GSTA1 0008152 metabolism Q5SZC1 29 2 DC 2 - 3 ±2.4 activity protein) 4 2 (1) 3 (3) 0016740 transferase activity

S100 calcium binding protein A10 40 2.1 25 1.2 27 3.0 0005509 calcium ion binding Q5T1C5 (Annexin II ligand, calpactin I, light 27 3 ±0.4 2 ±0.1 2 ±1.1

polypeptide (P11)) 23 (2) 3 (2) 5 (2)

23 -3.2 18 1.2 51 1.5 Actin-like protein 2 (Actin-related protein P61160 12 2 - 1 ±0.0 3 ±0.2 2) 4 (1) 3 (2) 7 (6)

CD276 antigen precursor 62 12 -1.7 17 1.1

Q5ZPR3 (Costimulatory molecule) (B7 homolog 23 4 PC 1 - 1 ±0.2

3) (B7-H3) (4Ig-B7-H3) 6 1 (1) 3 (3)

PCTP-like protein (PCTP-L) (StAR- related lipid transfer protein 10) 18 2.3 12 2.7 60 2.8

Q9Y365 (StARD10) (START domain-containing 24 1 - 1 ±0.6 4 ±0.9

protein 10) (Serologically defined colon 7 (1) 2 (2) 7 (5) cancer antigen 28) (Antigen NY-CO-28)

D-dopachrome decarboxylase (EC 62 -3.5 14 2.8 14 3.3 0004167 dopachrome isomerase

P30046 4.1.1.84) (D-dopachrome tautomerase) 35 4 - 1 - 1 - activity

(Phenylpyruvate tautomerase II) 12 (1) 1 (1) 1 (1)

0006874 calcium ion homeostasis 0005829 cytosol 23 29 -1.0 34 9.7 0006611 protein export from Calreticulin precursor (CRP55) 0005783 endoplasmic reticulum 0005509 calcium ion binding P27797 9 2 DC 2 - 2 ±2.9 nucleus (Calregulin) (HACBP) (ERp60) (grp60) 0005788 endoplasmic reticulum 0003677 DNA binding 3 2 (1) 5 (3) 0042981 regulation of apoptosis lumen 0006355 regulation of transcription, DNA-dependent

15 11 3.2 53 2.6 0004731 purine-nucleoside 0006139 nucleobase, nucleoside,

Q8N7G1 Hypothetical protein FLJ25678 20 1 DC 1 - 3 ±0.4 phosphorylase activity nucleotide and nucl

2 1 (1) 6 (3)

51 12 -3.9 16 -1.6 0005843 cytosolic small ribosomal 0005515 protein binding 0006412 protein biosynthesis P60866 40S ribosomal protein S20 22 3 PC 1 - 1 ±0.1 subunit 0003735 structural constituent of

8 1 (1) 3 (3) ribosome

50 -16.1 17 -2.9 12 1.6 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q7Z4W8 Heparin-binding protein HBp15 21 4 - 1 ±0.2 1 - ribosome 0005840 ribosome 14 (1) 2 (2) 1 (1)

20 -4.8 20 -3.6 38 -1.4 0003735 structural constituent of Ribosomal protein L21 variant 0005622 intracellular 0006412 protein biosynthesis Q59GK9 15 1 - 1 - 2 ±0.2 ribosome (Fragment) 0005840 ribosome 12 (1) 1 (1) 2 (2)

13 2.3 22 1.1 44 1.0 0009055 electron carrier activity Thioredoxin domain containing 4 Q4VXC1 12 1 - 2 ±0.2 3 ±0.1 0015035 protein disulfide (Endoplasmic reticulum) 3 (1) 2 (2) 3 (2) oxidoreductase activity

Actin-related protein 2/3 complex 22 12 1.5 43 3.2 0005200 structural constituent of 0005885 Arp2/3 protein complex 0045010 actin nucleation P59998 subunit 4 (ARP2/3 complex 20 kDa 17 2 PC 1 - 3 ±0.3 cytoskeleton

subunit) (p20-ARC) 6 1 (1) 4 (4)

50 -1.6 14 -1.5 11 -1.5 0016021 integral to membrane 0005509 calcium ion binding 0007155 cell adhesion Q9UII7 E-cadherin 7 3 - 1 - 1 ±0.2 0016020 membrane 0005515 protein binding 0007156 homophilic cell adhesion 6 (1) 1 (1) 2 (2)

27 1.4 21 -1.2 26 -1.2 Growth-inhibiting gene 2 protein (5H9 0016021 integral to membrane Q5J7W6 12 2 ±0.1 2 ±0.2 2 - antigen) 6 (2) 2 (2) 2 (1)

0005793 ER-Golgi intermediate compartment 0016021 integral to membrane 0006886 intracellular protein Transmembrane emp24 domain- 17 3.2 30 -1.4 27 1.0 0005792 microsome transport ISS:HGNC Q15363 containing protein 2 precursor 16 1 - 2 ±0.3 2 ±0.4 0005886 plasma membrane 0006903 vesicle targeting (Membrane protein p24A) 6 (1) 2 (2) 2 (2) 0042589 zymogen granule ISS:HGNC membrane

38 3.3 17 4.4 19 5.7 0005576 extracellular region 0008236 serine-type peptidase Prostasin precursor (EC 3.4.21.-) Q16651 9 2 ±0.1 1 - 1 ±3.1 0005615 extracellular space activity [Contains: Prostasin light chain 18 (2) 1 (1) 4 (3) 0005886 plasma membrane

29 -8.1 26 -2.4 16 -2.6 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q5JVH5 OTTHUMP00000018641 20 2 - 2 ±0.1 1 ±0.0 ribosome 0005840 ribosome 12 (1) 4 (3) 3 (2)

35 22 -2.9 14 -1.6 0005843 cytosolic small ribosomal 0003735 structural constituent of 0006412 protein biosynthesis P62847 40S ribosomal protein S24 20 2 PC 1 - 1 - subunit ribosome

17 1 (1) 1 (1)

29 -4.9 11 2.5 30 1.8

P57053 Histone H2B type F-S (H2B.s) (H2B/s) 41 2 - 1 - 2 ±0.1

5 (1) 1 (1) 4 (3)

31 8.2 11 1.4 24 3.9 Receptor expression-enhancing protein Q96HR9 22 2 - 1 - 2 - 6 (Polyposis locus protein 1-like 1) 13 (1) 1 (1) 2 (1)

30 17 -2.1 18 -1.9 0005842 cytosolic large ribosomal 0003723 RNA binding 0006412 protein biosynthesis Q02543 60S ribosomal protein L18a 15 2 PC 1 - 1 - subunit 0003735 structural constituent of

8 1 (1) 2 (1) ribosome

30 18 -1.3 15 -2.0 60S ribosomal protein L24 (Ribosomal 0005515 protein binding P83731 13 2 PC 1 ±0.2 1 - protein L30) 7 2 (2) 2 (1)

35 1.6 11 3.3 16 2.3 0005615 extracellular space 0005386 carrier activity 0006810 transport Q5D0D7 ALB protein 3 2 ±0.9 1 - 1 ±0.3

20 (2) 1 (1) 2 (2)

13 11 -1.5 38 -3.5 0003676 nucleic acid binding Q59EK7 CS0DF038YO05 variant (Fragment) 11 1 DC 1 - 3 ±0.0 0000166 nucleotide binding 2 1 (1) 3 (2)

15 11.8 16 1.2 29 12.0 0005634 nucleus 0006260 DNA replication P20962 Parathymosin 22 1 - 1 - 2 ±7.6

4 (1) 1 (1) 4 (4)

0030492 hemoglobin binding 0030185 nitric oxide transport 13 14 3.1 32 3.8 0019825 oxygen binding Hemoglobin subunit beta (Hemoglobin 0005833 hemoglobin complex 0015671 oxygen transport P68871 26 1 DC 1 - 2 ±1.7 0005344 oxygen transporter beta chain) (Beta-globin) 0045429 positive regulation of 2 1 (1) 3 (2) activity nitric oxide biosynt 0008430 selenium binding

18 11 -2.2 31 -1.8 0005852 eukaryotic translation 0003743 translation initiation 0006446 regulation of translational Eukaryotic translation initiation factor 3 Q99613 4 1 PC 1 - 2 ±0.2 initiation factor 3 factor activity initiation subunit 8 (eIF3 p110) (eIF3c) 1 1 (1) 2 (2)

29 16 -3.0 12 -1.4 0005842 cytosolic large ribosomal 0003729 mRNA binding 0006412 protein biosynthesis P42766 60S ribosomal protein L35 11 2 PC 1 - 1 - subunit 0003735 structural constituent of

4 1 (1) 1 (1) 0005730 nucleolus ribosome

29 -4.8 14 -2.5 11 -2.9

P62899 60S ribosomal protein L31 18 2 ±0.1 1 - 1 -

15 (2) 1 (1) 1 (1)

27 16 -1.8 28 -2.8 0005887 integral to plasma

O00592 Podocalyxin-like protein 1 precursor 12 2 PC 1 - 2 ±0.1 membrane

3 2 (1) 2 (2)

Programmed cell death protein 6 92 3.0 15 2.1 37 2.8 0008624 induction of apoptosis by

O75340 (Probable calcium-binding protein ALG- 43 6 ±0.8 1 - 2 ±0.6 extracellular sig

2) 49 (6) 1 (1) 6 (2)

15 22 -5.5 15 -2.0 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q5HY50 Ribosomal protein L10 (Fragment) 14 1 PC 2 - 1 - ribosome 0005840 ribosome 4 2 (1) 1 (1)

0030036 actin cytoskeleton 14 -2.2 18 2.4 18 4.1 0015629 actin cytoskeleton 0003779 actin binding organization and biogenesis Q4VBQ4 Profilin 2 10 1 - 1 - 1 - 0007010 cytoskeleton 3 (1) 1 (1) 2 (1) organization and biogenesis

20 16 1.1 11 -1.9 0005524 ATP binding 0016459 myosin Q4KMR3 Myosin IE 2 1 PC 1 - 1 - 0005516 calmodulin binding

1 1 (1) 1 (1) 0003774 motor activity

0003735 structural constituent of 17 11 -1.2 16 -3.1 0005843 cytosolic small ribosomal ribosome 0043037 translation P62266 40S ribosomal protein S23 15 1 PC 1 - 1 - subunit 0045182 translation regulator 5 1 (1) 1 (1) 0005840 ribosome activity

Phosphoacetylglucosamine mutase (EC 0004610 5.4.2.3) (PAGM) (Acetylglucosamine 34 12 2.9 phosphoacetylglucosamine 0006041 glucosamine metabolism O95394 phosphomutase) (N-acetylglucosamine- 8 2 DC 1 - mutase activity phosphate mutase) 4 1 (1)

(Phosphoglucomutase 3) 63 5.0 12 1.8

P61225 Ras-related protein Rap-2b precursor 20 4 ±2.2 1 -

11 (2) 1 (1)

14 1.4 14 -1.7 14 0005843 cytosolic small ribosomal 0003735 structural constituent of 0006412 protein biosynthesis P62857 40S ribosomal protein S28 17 1 - 1 - 1 subunit ribosome

4 (1) 1 (1) 1

Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 0000781 chromosome, telomeric 0050220 prostaglandin-E 0001516 prostaglandin 49 2.5 15 1.3 30 synthase) (cPGES) (Telomerase- region synthase activity biosynthesis Q15185 27 3 ±0.6 1 - 2 binding protein p23) (Hsp90 co- 0005697 telomerase holoenzyme 0003720 telomerase activity 0007165 signal transduction 15 (2) 1 (1) 3 chaperone) (Progesterone receptor complex 0051082 unfolded protein binding 0000723 telomere maintenance complex p23)

85 -4.2 11 -1.6 14 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q8WVX7 Ribosomal protein S19 (Fragment) 27 6 ±1.1 1 - 1 ribosome 0005840 ribosome 19 (4) 1 (1) 1

69 31 -1.0 140 1.2 Cadherin 17, (Cadherin 17, LI cadherin) 0016020 membrane 0005509 calcium ion binding 0007156 homophilic cell adhesion Q2M2E0 19 5 2 - 8 ±0.2 (Liver-intestine) 10 2 (1) 16 (9)

48 13 -1.6 59 1.4 Brain abundant, membrane attached Q9BWA5 41 3 1 - 3 ±0.2 signal protein 1 3 1 (1) 4 (2)

0004871 signal transducer activity AH receptor-interacting protein (AIP) 9 11 1.9 43 2.7 0003713 transcription coactivator (Aryl-hydrocarbon receptor-interacting 0005737 cytoplasm O00170 8 1 1 - 2 ±1.0 activity protein) (Immunophilin homolog ARA9) 1 1 (1) 4 (3) 0008134 transcription factor (HBV-X-associated protein 2) binding

14 1.7 41 -1.9 0004674 protein serine/threonine 0000074 regulation of progression Cyclin G-associated kinase (EC O14976 5 1 - 3 - kinase activity through cell cycle 2.7.11.1) 1 (1) 3 (1)

Actin-related protein 2/3 complex 12 28 -1.2 79 1.5 0005200 structural constituent of 0005885 Arp2/3 protein complex 0006928 cell motility O15144 subunit 2 (ARP2/3 complex 34 kDa 20 1 2 ±0.2 5 ±0.2 cytoskeleton

subunit) (p34-ARC) 2 3 (3) 7 (7)

Eukaryotic translation initiation factor 3 16 -3.4 28 -2.0 0005852 eukaryotic translation 0005515 protein binding 0006446 regulation of translational O15372 subunit 3 (eIF-3 gamma) (eIF3 p40 12 1 - 2 ±0.1 initiation factor 3 0008135 translation factor activity, initiation subunit) (eIF3h) 1 (1) 2 (2) nucleic acid b Bifunctional 3'-phosphoadenosine 5'- 0005524 ATP binding phosphosulfate synthetase 2 (PAPS 0016779 nucleotidyltransferase synthetase 2) (PAPSS 2) (Sulfurylase 15 3.3 21 12.7 activity 0005622 intracellular 0001501 skeletal development O95340 kinase 2) (SK2) (SK 2) [Includes: 2 1 - 1 - 0004781 sulfate

Sulfate adenylyltransferase (EC 2.7.7.4) 1 (1) 1 (1) adenylyltransferase (ATP) activity (Sulfate adenylate transferase) (SAT) 0016740 transferase activity (ATP-sulfuryl

11 1.9 31 1.5 0004362 glutathione-disulfide Glutathione reductase, mitochondrial P00390 6 1 - 2 - reductase activity precursor (EC 1.8.1.7) (GR) (GRase) 1 (1) 2 (1)

13 1.1 76 3.3 Argininosuccinate synthase (EC 0005737 cytoplasm 0005515 protein binding 0000050 urea cycle P00966 15 1 - 5 ±0.9 6.3.4.5) (Citrulline--aspartate ligase) 1 (1) 5 (4)

Galectin-2 (Beta-galactoside-binding 13 1.2 15 2.5

P05162 lectin L-14-II) (Lactose-binding lectin 2) 9 1 - 1 -

(S-Lac lectin 2) (HL14) 1 (1) 1 (1)

0030041 actin filament Gelsolin precursor (Actin- 10 1.6 57 3.2 0015629 actin cytoskeleton polymerization 0005509 calcium ion binding P06396 depolymerizing factor) (ADF) (Brevin) 8 1 - 4 ±1.0 0005829 cytosol 0051014 actin filament severing 0005515 protein binding (AGEL) 1 (1) 6 (3) 0005576 extracellular region 0051016 barbed-end actin filament capping

Xaa-Pro dipeptidase (EC 3.4.13.9) (X- 28 2.7 30 3.1 0008472 metallocarboxypeptidase 0006520 amino acid metabolism P12955 Pro dipeptidase) (Proline dipeptidase) 7 2 ±0.3 2 ±0.4 D activity 0006508 proteolysis (Prolidase) (Imidodipeptidase) 3 (2) 3 (3)

11 2.0 79 2.2 0005737 cytoplasm 0008603 cAMP-dependent protein 0007242 intracellular signaling cAMP-dependent protein kinase type II- P13861 15 1 - 5 ±0.3 0005624 membrane fraction kinase regulator act cascade alpha regulatory subunit 1 (1) 7 (7) 0005886 plasma membrane

CD59 glycoprotein precursor (Membrane attack complex inhibition factor) (MACIF) (MAC-inhibitory protein) 14 -1.8 29 -1.1 0005624 membrane fraction 0007596 blood coagulation 0005515 protein binding P13987 (MAC-IP) (Protectin) (MEM43 antigen) 18 1 - 2 ±0.3 0005886 plasma membrane 0007166 cell surface receptor

(Membrane inhibitor of reactive lysis) 1 (1) 2 (2) NAS:ProtInc linked signal transdu (MIRL) (20 kDa homologous restriction factor) (HRF-20 0007275 development CMP-N-acetylneuraminate-beta- 0040007 growth galactosamide-alpha-2,6- 0006959 humoral immune 14 1.7 13 2.1 0003835 beta-galactoside alpha- sialyltransferase (EC 2.4.99.1) (Beta- 0016021 integral to membrane response P15907 2 1 - 1 - 2,6-sialyltransferas galactoside alpha-2,6-sialyltransferase) 0009311 oligosaccharide 1 (1) 1 (1) (Alpha 2,6-ST) (Sialyltransferase 1) metabolism (ST6Gal I) (B-cell antigen CD75) 0006464 protein modification

Probable ATP-dependent RNA helicase 15 -1.5 42 -1.8 0005634 nucleus 0003724 RNA helicase activity 0016049 cell growth P17844 DDX5 (EC 3.6.1.-) (DEAD box protein 5 1 ±0.3 3 ±0.1

5) (RNA helicase p68) 2 (2) 3 (3) Adenosylhomocysteinase (EC 3.3.1.1) 10 26 1.6 64 1.9 0004013 0006730 one-carbon compound 0005737 cytoplasm P23526 (S-adenosyl-L-homocysteine hydrolase) 12 1 2 ±0.3 4 ±0.3 adenosylhomocysteinase activity metabolism

(AdoHcyase) 3 5 (4) 13 (10)

Acetyl-CoA acetyltransferase, 23 1.6 28 2.1 0003985 acetyl-CoA C- 0005739 mitochondrion P24752 mitochondrial precursor (EC 2.3.1.9) 11 2 - 2 ±0.6 acetyltransferase activity

(Acetoacetyl-CoA thiolase) (T2) 2 (1) 3 (2)

CAD protein [Includes: Glutamine- 23 1.5 139 1.2 0004088 carbamoyl-phosphate

P27708 dependent carbamoyl-phosphate 6 2 - 8 ±0.1 synthase (glutamine-hyd

synthase (EC 6.3.5.5) 2 (1) 13 (10)

15 1.4 44 2.3 0008466 glycogenin

P46976 Glycogenin-1 (EC 2.4.1.186) 12 1 - 3 - glucosyltransferase activity

1 (1) 3 (1)

11 -1.4 12 3.1 Dermcidin precursor (Preproteolysin) 0005576 extracellular region P81605 20 1 - 1 - [Contains: Survival-promoting peptide 1 (1) 1 (1)

Large neutral amino acids transporter 0006520 amino acid metabolism small subunit 1 (L-type amino acid 11 -2.4 50 -2.1 0016021 integral to membrane 0015175 neutral amino acid 0015804 neutral amino acid Q01650 transporter 1) (4F2 light chain) (4F2 LC) 9 1 - 3 ±0.2 0005886 plasma membrane transporter activity transport (4F2LC) (CD98 light chain) (Integral 1 (1) 4 (3) NAS:ProtInc 0042605 peptide antigen binding 0006810 transport membrane protein E16) (hLAT1)

Splicing factor, arginine/serine-rich 1 13 -1.2 16 1.1 0006397 mRNA processing (pre-mRNA-splicing factor SF2, P33 0005515 protein binding Q07955 4 1 - 1 - 0006376 mRNA splice site subunit) (Alternative-splicing factor 1) 1 (1) 2 (1) selection (ASF-1)

0004003 ATP-dependent DNA ATP-dependent RNA helicase A (EC 28 -1.8 98 -1.7 helicase activity 0005737 cytoplasm Q08211 3.6.1.-) (Nuclear DNA helicase II) (NDH 8 2 - 6 ±0.3 0004004 ATP-dependent RNA 0005634 nucleus II) (DEAH box protein 9) 2 (1) 9 (6) helicase activity 0005515 protein binding

17 4.2 25 5.3

Q15200 Prothymosin alpha 10 1 ±0.9 2 ±3.2

2 (2) 5 (5)

12 -2.0 16 -2.4 Transmembrane 9 superfamily member 0016021 integral to membrane 0005215 transporter activity 0006810 transport Q2TAY5 3 1 - 1 ±0.3 2 1 (1) 3 (2)

Full-length cDNA clone 10 15 -2.8 18 -3.8 0005850 eukaryotic translation 0003723 RNA binding 0006412 protein biosynthesis Q53XC0 CS0DL010YH08 of B cells (Ramos cell 3 1 1 - 1 - initiation factor 2 0003743 translation initiation

line) of Homo sapiens (human) 1 2 (1) 2 (1) factor activity 13 2.1 33 1.6 Calpain 2, large [catalytic] subunit 0005622 intracellular 0005509 calcium ion binding 0006508 proteolysis Q59EF6 3 1 - 2 ±0.5 variant (Fragment) 0004198 calpain activity 1 (1) 3 (3)

11 2.1 64 1.6 WD repeat-containing protein 1 isoform Q59ER5 11 1 - 4 ±0.3 1 variant (Fragment) 1 (1) 5 (3)

11 -1.3 69 -2.2 0004518 nuclease activity Q59FF0 EBNA-2 co-activator variant (Fragment) 6 1 - 4 ±0.2 0003676 nucleic acid binding 1 (1) 5 (3)

12 -2.2 64 -2.4 0008097 5S rRNA binding Ribosomal protein L5 variant 0005622 intracellular 0006412 protein biosynthesis Q59GX9 22 1 ±0.2 4 ±0.9 0003735 structural constituent of (Fragment) 0005840 ribosome 2 (2) 4 (3) ribosome

0005524 ATP binding 0006424 glutamyl-tRNA 10 -2.0 79 1.0 0004818 glutamate-tRNA ligase aminoacylation 0005737 cytoplasm Q5H9S5 Hypothetical protein DKFZp313B047 6 1 - 5 ±0.2 activity 0006433 prolyl-tRNA

1 (1) 8 (5) 0004827 proline-tRNA ligase aminoacylation activity 0006412 protein biosynthesis

15 -3.3 67 -1.4 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q5QTS3 FWP004 24 1 - 5 ±0.2 ribosome 0015934 large ribosomal subunit 1 (1) 5 (4)

19 1.0 16 1.6 0005783 endoplasmic reticulum Q5UEP2 RTN3-A1 1 1 - 1 -

1 (1) 2 (1)

9 12 3.6 57 2.3 Dimethylarginine 0016787 hydrolase activity Q5VWX2 18 1 1 - 4 ±0.3 dimethylaminohydrolase 1 1 1 (1) 5 (4)

12 11 -1.1 30 1.0 0016787 hydrolase activity Q6IAH3 VPS29 protein 12 1 1 - 2 ±0.2

4 1 (1) 5 (4)

10 17 -2.0 28 -1.6 0005524 ATP binding 0006432 phenylalanyl-tRNA 0005737 cytoplasm Q6IBR2 FARSLA protein 9 1 1 - 2 ±0.3 0004826 phenylalanine-tRNA aminoacylation

1 1 (1) 2 (2) ligase activity

27 -1.6 66 -1.1 0006886 intracellular protein 0030125 clathrin vesicle coat Q6MZV5 Hypothetical protein DKFZp686M09245 12 2 ±0.3 5 ±0.2 transport

2 (2) 8 (7) 0006810 transport 30 -1.5 66 -1.8 0017134 fibroblast growth factor 0016020 membrane Q6P9D1 Golgi apparatus protein 1 3 2 ±0.0 4 ±0.2 binding

3 (2) 4 (2)

16 -2.8 36 -2.4 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q76M58 40S ribosomal protein S12 18 1 ±0.4 2 ±0.3 ribosome 0005840 ribosome 2 (2) 4 (3)

0005504 fatty acid binding ISS:HGNC 0009790 embryonic development 0030228 lipoprotein receptor ISS:HGNC 11 1.1 58 1.5 activity ISS:HGNC 0005886 plasma membrane 0042953 lipoprotein transport Q86X29 Lipolysis-stimulated lipoprotein receptor 10 1 - 4 ±0.1 0030169 low-density lipoprotein ISS:HGNC 1 (1) 5 (4) binding ISS:HGNC 0001889 liver development 0017129 triglyceride binding ISS:HGNC ISS:HGNC

43 -2.1 167 -1.7 0008565 protein transporter 0006888 ER to Golgi vesicle- COPA protein (Coatomer protein 0030126 COPI vesicle coat Q8IXZ9 12 3 ±0.4 10 ±0.2 activity mediated transport complex, subunit alpha) 0005783 endoplasmic reticulum 3 (3) 11 (9) 0006605 protein targeting

14 1.6 48 1.3 0016740 transferase activity Q8IZK8 Ribonuclease/angiogenin inhibitor 8 1 - 3 ±0.2

1 (1) 6 (4)

16 9.9 35 9.4 0016021 integral to membrane Q8NCR9 Transmembrane protein 12 12 1 - 2 ±3.6

1 (1) 4 (4)

CDNA FLJ31747 fis, clone 18 -1.6 15 -2.7 0000166 nucleotide binding 0005622 intracellular Q96MX4 NT2RI2007377, highly similar to RNA- 2 1 - 1 - 0003723 RNA binding 0005634 nucleus BINDING PROTEIN EWS 1 (1) 1 (1) 0008270 zinc ion binding

21 2.3 22 1.8 DnaJ homolog subfamily C member 5 Q9H3Z4 7 1 - 1 ±0.3 (Cysteine string protein) (CSP) 1 (1) 2 (2)

19 -2.6 46 -1.9 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q9NY85 Ribosomal protein L3 (Fragment) 13 1 - 3 ±0.6 ribosome 0005840 ribosome 1 (1) 3 (2)

34 -2.7 46 -2.1 0016021 integral to membrane 0005540 hyaluronic acid binding 0007155 cell adhesion Q9UJ36 Transmembrane glycoprotein precursor 5 2 ±0.1 3 ±0.1 0016020 membrane 4 (2) 7 (4) 13 2.4 14 9.6 0016787 hydrolase activity Q9ULG2 KIAA1258 protein (Fragment) 2 1 - 1 -

1 (1) 1 (1)

0007050 cell cycle arrest Proliferation-associated protein 2G4 13 -2.1 77 -2.1 0005515 protein binding 0005634 nucleus 0008283 cell proliferation Q9UQ80 (Cell cycle protein p38-2G4 homolog) 14 1 - 5 ±0.3 0003700 transcription factor 0045892 negative regulation of (hG4-1) (ErbB3-binding protein 1) 1 (1) 6 (5) activity transcription, DNA-d

Eukaryotic translation initiation factor 3 54 35 -3.0 0005852 eukaryotic translation 0003743 translation initiation 0006446 regulation of translational O00303 subunit 5 (eIF-3 epsilon) (eIF3 p47 16 4 PC 2 ±0.6 initiation factor 3 factor activity initiation subunit) (eIF3f) 6 3 (3)

0006891 intra-Golgi vesicle- 69 35 1.1 Coatomer subunit epsilon (Epsilon-coat 0030126 COPI vesicle coat mediated transport O14579 23 4 PC 2 - protein) (Epsilon-COP) 0005794 Golgi apparatus 0006890 retrograde vesicle- 6 2 (1) mediated transport, Golg

0005178 integrin binding 0007267 cell-cell signaling 0009986 cell surface 0004222 metalloendopeptidase 0051089 constitutive protein ADAM 10 precursor (EC 3.4.24.81) (A 0005737 cytoplasm activity ectodomain proteolysis disintegrin and metalloproteinase 15 11 1.1 0005794 Golgi apparatus 0042803 protein 0001701 embryonic development O14672 domain 10) (Mammalian disintegrin- 3 1 PC 1 - 0005798 Golgi-associated vesicle homodimerization activity (sensu Mammalia) metalloprotease) (Kuzbanian protein 2 1 (1) 0016021 integral to membrane 0019901 protein kinase binding 0007229 integrin-mediated homolog) (CDw156c antigen) 0005634 nucleus IS 0042169 SH2 domain binding I signaling pathway

Proteasome subunit alpha type 7 (EC 91 -2.6 20 61 2.0 0000502 proteasome complex O14818 3.4.25.1) (Proteasome subunit RC6-1) 40 5 ±1.3 1 4 ±0.7

(Proteasome subunit XAPC7) 20 (3) 1 6 (3)

44 111 -2.0

O15031 Plexin-B2 precursor (MM1) 7 4 PC 7 ±0.3

5 9 (4)

A-kinase anchor protein 7 isoforms 0016324 apical plasma membrane 0007242 intracellular signaling alpha and beta (Protein kinase A- 34 34 2.2 0016328 lateral plasma 0051018 protein kinase A binding cascade O43687 anchoring protein 7 isoforms 25 2 DC 2 ±0.1 membrane 0006811 ion transport alpha/beta) (A-kinase anchor protein 8 2 (2) 0005886 plasma membrane 0008104 protein localization 18) Mannose-6-phosphate receptor-binding protein 1 (Cargo selection protein 100 -1.7 85 3.4 0005737 cytoplasm 0016192 vesicle-mediated TIP47) (47 kDa mannose 6-phosphate O60664 30 6 ±0.5 5 ±0.7 0005768 endosome transport receptor-binding protein) (47 kDa MPR- 19 (2) 7 (5) 0005794 Golgi apparatus binding protein) (Placental protein 17) (PP17) 0006024 glycosaminoglycan biosynthesis UDP-glucose 6-dehydrogenase (EC 36 26 36 -1.0 0009055 electron carrier activity 0006011 UDP-glucose O60701 1.1.1.22) (UDP-Glc dehydrogenase) 18 3 DC 2 2 - 0003979 UDP-glucose 6- metabolism (UDP-GlcDH) (UDPGDH) 4 3 3 (1) dehydrogenase activity 0006065 UDP-glucuronate biosynthesis 44 -1.3 44 1.8 Sorting nexin-2 (Transformation-related 0006897 endocytosis O60749 12 3 - 3 ±0.7 gene 9 protein) 4 (1) 4 (3)

110 3.4 46 2.4 0005793 ER-Golgi intermediate 0006888 ER to Golgi vesicle- Vesicle-trafficking protein SEC22b 0005515 protein binding O75396 42 7 ±1.7 3 ±0.6 compartment mediated transport (SEC22 vesicle-trafficking protein-like 1) 25 (3) 3 (3)

34 -1.3 11 -3.8 0005515 protein binding 0042147 retrograde transport, Vacuolar protein sorting 26A (Vesicle 0005829 cytosol O75436 15 3 - 1 - 0008565 protein transporter endosome to Golgi protein sorting 26A) (hVPS26) 9 (1) 1 (1) activity

72 1.0 38 2.6 0006098 pentose-phosphate 6-phosphogluconolactonase (EC O95336 39 5 ±0.3 2 ±0.2 shunt 3.1.1.31) (6PGL) 19 (3) 2 (2)

NG,NG-dimethylarginine 0006916 anti-apoptosis dimethylaminohydrolase 2 (EC 0006527 arginine catabolism 97 17 3.6 3.5.3.18) (Dimethylargininase-2) 0003824 catalytic activity 0006809 nitric oxide biosynthesis O95865 37 6 DC 1 - (Dimethylarginine 0007263 nitric oxide mediated 12 1 (1) dimethylaminohydrolase 2) (DDAHII) signal transduction (S-phase protein) (Protein G6a)

104 -1.2 34 1.4 0004000 adenosine deaminase 0019735 antimicrobial humoral Adenosine deaminase (EC 3.5.4.4) P00813 33 6 ±0.2 2 ±0.1 activity response (sensu Verte (Adenosine aminohydrolase) 16 (4) 4 (3)

HLA class I histocompatibility antigen, 63 -2.2 16 45 -1.6 0005515 protein binding P01892 A-2 alpha chain precursor (MHC class I 21 4 - 1 3 ±0.2

antigen A*2) 20 (1) 2 6 (3)

0008035 high-density lipoprotein Apolipoprotein A-I precursor (Apo-AI) 106 -1.7 71 2.4 0008203 cholesterol metabolism 0005576 extracellular region binding P02647 (ApoA-I) [Contains: Apolipoprotein A- 40 7 ±0.5 5 ±0.5 0030301 cholesterol transport 0005615 extracellular space 0008289 lipid binding I(1-242)] 19 (4) 6 (5) 0008015 circulation 0005515 protein binding

20 1.4 21 1.7 Apolipoprotein C-III precursor (Apo-CIII) 0005576 extracellular region 0006629 lipid metabolism P02656 16 1 - 1 - (ApoC-III) 7 (1) 1 (1)

Calpain small subunit 1 (CSS1) (Calcium-dependent protease small subunit 1) (Calcium-dependent 49 1.2 43 1.9 0008284 positive regulation of cell 0004198 calpain activity P04632 protease small subunit) (CDPS) 23 3 - 3 - proliferation 0005515 protein binding (Calpain regulatory subunit) (Calcium- 13 (1) 7 (1) activated neutral proteinase small subunit) (CANP small subunit) Sodium/potassium-transporting ATPase 48 1.7 40 -1.4 0005890 sodium:potassium- 0005391 sodium:potassium- 0006810 transport P05026 subunit beta-1 (Sodium/potassium- 29 3 ±0.7 3 ±0.5 exchanging ATPase complex exchanging ATPase activity

dependent ATPase beta-1 subunit) 24 (2) 5 (3)

0004693 cyclin-dependent protein Cell division control protein 2 homolog 64 -2.3 43 1.6 0030496 midbody kinase activity 0006916 anti-apoptosis (EC 2.7.11.22) (EC 2.7.11.23) (p34 P06493 17 5 ±0.4 3 - 0005634 nucleus 0005515 protein binding 0000074 regulation of progression protein kinase) (Cyclin-dependent 14 (3) 4 (1) 0005876 spindle microtubule 0004672 protein kinase activity through cell cycle NAS:ProtInc kinase 1) (CDK1) NAS:ProtInc

0005524 ATP binding Multidrug resistance protein 1 (EC 14 105 -1.6 0009986 cell surface 0042626 ATPase activity, coupled 0042493 response to drug P08183 3.6.3.44) (P-glycoprotein 1) (CD243 8 1 PC 6 ±0.2 0016021 integral to membrane to transmembrane m 0006810 transport antigen) 1 6 (4) 0005624 membrane fraction 0005215 transporter activity

Melanotransferrin precursor 80 38 4.0 0005887 integral to plasma 0005506 iron ion binding P08582 (Melanoma-associated antigen p97) 15 5 DC 2 ±1.0 membrane

(CD228 antigen) 10 2 (2)

148 -6.0 69 1.2 0005525 GTP binding 0007165 signal transduction P11234 Ras-related protein Ral-B 41 9 - 4 ±0.2 0005515 protein binding 22 (1) 6 (3)

0004329 formate-tetrahydrofolate ligase activity C-1-tetrahydrofolate synthase, 162 1.2 24 45 -1.3 0004477 methenyltetrahydrofolate cytoplasmic (C1-THF synthase) 0005739 mitochondrion P11586 18 12 ±0.2 2 3 - cyclohydrolase act [Includes: Methylenetetrahydrofolate 31 (7) 2 3 (1) 0004486 dehydrogenase (EC 1.5.1.5) methylenetetrahydrofolate dehydrogenase act

Ribose-phosphate pyrophosphokinase 27 -1.4 44 -1.5 0004749 ribose phosphate 0006139 nucleobase, nucleoside, II (EC 2.7.6.1) (Phosphoribosyl P11908 19 2 - 3 ±0.2 diphosphokinase activity nucleotide and nucl pyrophosphate synthetase II) (PRS-II) 3 (1) 4 (2) (PPRibP)

0008143 poly(A) binding 0006378 mRNA polyadenylation 19 -1.2 58 1.3 Polyadenylate-binding protein 1 0005737 cytoplasm 0005515 protein binding 0048255 mRNA stabilization P11940 9 1 - 4 ±0.2 (Poly(A)-binding protein 1) (PABP 1) 0008494 translation activator 0045946 positive regulation of 3 (1) 4 (3) activity translation

0008283 cell proliferation 0006281 DNA repair 0006260 DNA replication 46 11 35 -1.0 0005663 DNA replication factor C Proliferating cell nuclear antigen 0005515 protein binding 0048015 phosphoinositide- P12004 18 3 PC 1 2 ±0.0 complex (PCNA) (Cyclin) mediated signaling 4 1 4 (2) 0000074 regulation of progression through cell cycle

Dipeptidase 1 precursor (EC 3.4.13.19) 33 12 21 -1.2 0004237 membrane dipeptidase (Microsomal dipeptidase) (Renal P16444 17 3 PC 1 1 - activity dipeptidase) (hRDP) 4 1 1 (1) (Dehydropeptidase-I) 0043297 apical junction assembly 0005912 adherens junction 0007155 cell adhesion 0030055 cell-matrix junction 34 1.2 18 -1.6 0006928 cell motility 0043034 costamere 0045294 alpha-catenin binding P18206 Vinculin (Metavinculin) 3 2 - 1 - 0030032 lamellipodium biogenesis 0005856 cytoskeleton 0016491 oxidoreductase activity 3 (1) 1 (1) 0030336 negative regulation of 0005925 focal adhesion cell migration TAS:UniP 0005911 intercellular junct

Calnexin precursor (Major 16 -1.4 19 -2.0 histocompatibility complex class I 0005737 cytoplasm 0005509 calcium ion binding 0001525 angiogenesis P27824 2 1 - 1 - antigen-binding protein p88) (p90) 0005783 endoplasmic reticulum 0051082 unfolded protein binding 0009306 protein secretion 6 (1) 1 (1) (IP90)

Probable isomerase MAWBP (EC 5.1.- 146 65 2.9

P30039 .-) (MAWD-binding protein) (Unknown 45 10 DC 4 ±0.3

protein 32 from 2D-page of liver tissue) 22 5 (4)

UMP-CMP kinase (EC 2.7.4.14) (Cytidylate kinase) (Deoxycytidylate kinase) (Cytidine monophosphate 100 16 2.0 0009220 pyrimidine ribonucleotide kinase) (Uridine 0005737 cytoplasm 0004849 uridine kinase activity P30085 36 7 DC 1 ±0.4 biosynthesis monophosphate/cytidine 0005634 nucleus 13 2 (2) monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) (Uridine monophosphate kinase)

46 -6.2 41 -1.4 0003723 RNA binding 0005840 ribosome 0006412 protein biosynthesis P32969 60S ribosomal protein L9 32 3 - 3 ±0.1 0003735 structural constituent of

18 (1) 3 (2) ribosome

0006891 intra-Golgi vesicle- 14 16 84 -1.6 Coatomer subunit beta' (Beta'-coat 0030126 COPI vesicle coat mediated transport P35606 8 1 PC 1 6 ±0.2 protein) (Beta'-COP) (p102) 0006890 retrograde vesicle- 2 1 7 (4) mediated transport, Golg

Heterogeneous nuclear 23 32 -1.9 0030530 heterogeneous nuclear ribonucleoprotein G (hnRNP G) (RNA- 0005515 protein binding P38159 10 2 PC 2 ±0.2 ribonucleoprotein com binding motif protein, X chromosome) 0003723 RNA binding 3 2 (2) (Glycoprotein p43)

Ubiquitin carboxyl-terminal hydrolase 5 0004197 cysteine-type (EC 3.1.2.15) (Ubiquitin thioesterase 5) 15 62 4.4 endopeptidase activity 0005764 lysosome P45974 (Ubiquitin-specific-processing protease 6 1 DC 4 ±2.0 0005515 protein binding

5) (Deubiquitinating enzyme 5) 2 6 (5) 0008581 ubiquitin-specific (Isopeptidase T) protease 5 activity

41 39 -2.3 0005843 cytosolic small ribosomal 0003723 RNA binding 0006412 protein biosynthesis P46781 40S ribosomal protein S9 24 4 PC 3 ±0.4 subunit 0003735 structural constituent of

8 3 (2) ribosome

60 -7.0 44 -1.9 0005843 cytosolic small ribosomal 0003723 RNA binding 0006412 protein biosynthesis P46783 40S ribosomal protein S10 33 4 ±0.8 3 ±0.1 subunit 0003735 structural constituent of

14 (2) 4 (4) ribosome 0006520 amino acid metabolism Glutathione synthetase (EC 6.3.2.3) 23 63 3.0 0004363 glutathione synthase 0007399 nervous system

P48637 (Glutathione synthase) (GSH 16 2 DC 4 ±0.6 activity development

synthetase) (GSH-S) 2 6 (5) 0006979 response to oxidative stress

MARCKS-related protein (MARCKS-like 27 56 -1.1 protein 1) (Macrophage myristoylated 0005886 plasma membrane P49006 31 2 PC 3 ±0.1 alanine-rich C kinase substrate) (Mac- 3 9 (7) MARCKS) (MacMARCKS)

Proteasome subunit beta type 3 (EC 66 -3.5 39 1.4 3.4.25.1) (Proteasome theta chain) 0000502 proteasome complex P49720 30 4 ±0.8 2 ±0.2 (Proteasome chain 13) (Proteasome 23 (2) 5 (3) component C10-II)

Histidine triad nucleotide-binding protein 1 (Adenosine 5'- 15 1.2 23 3.9 0005856 cytoskeleton 0005080 protein kinase C binding 0007165 signal transduction P49773 monophosphoramidase) (Protein kinase 27 1 - 1 ±0.8 0005634 nucleus C inhibitor 1) (Protein kinase C- 7 (1) 2 (2) interacting protein 1) (PKCI-1)

81 26 1.8 0007585 respiratory gaseous Histamine N-methyltransferase (EC P50135 30 5 DC 2 ±0.4 exchange 2.1.1.8) (HMT) 12 2 (2)

Sulfate transporter (Diastrophic 21 18 1.6 0005887 integral to plasma 0015116 sulfate transporter 0008272 sulfate transport P50443 dysplasia protein) (Solute carrier family 5 1 PC 1 ±0.2 membrane activity

26 member 2) 1 2 (2) 0005624 membrane fraction

Dual specificity protein phosphatase 3 73 3.1 20 3.4 0004725 protein tyrosine 0006470 protein amino acid

P51452 (EC 3.1.3.48) (EC 3.1.3.16) (Dual 35 5 ±0.2 1 - phosphatase activity dephosphorylation

specificity protein phosphatase VHR) 18 (3) 1 (1)

39 -1.8 15 44 1.1 0008290 F-actin capping protein 0006928 cell motility F-actin capping protein alpha-1 subunit 0003779 actin binding P52907 14 3 - 1 3 ±0.2 complex 0006461 protein complex (CapZ alpha-1) 4 (1) 1 3 (3) assembly

Sodium/potassium-transporting ATPase 18 1.7 33 -5.1 0005890 sodium:potassium- 0005391 sodium:potassium- subunit beta-3 (Sodium/potassium- 0006810 transport P54709 11 1 - 2 ±1.5 exchanging ATPase complex exchanging ATPase activity dependent ATPase beta-3 subunit) 11 (1) 3 (2) (ATPB-3) (CD298 antigen)

Exportin-2 (Exp2) (Importin-alpha re- 161 2.1 13 79 1.1 0008262 importin-alpha export exporter) (Chromosome segregation 1- 0005737 cytoplasm 0006915 apoptosis P55060 22 12 ±0.8 1 5 ±0.1 receptor activity like protein) (Cellular apoptosis 0005634 nucleus 0008283 cell proliferation 25 (6) 1 10 (8) susceptibility protein)

31 -1.2 13 2.6 0009156 ribonucleoside Adenosine kinase (EC 2.7.1.20) (AK) 0004001 adenosine kinase activity P55263 15 2 - 1 - monophosphate biosynthesis (Adenosine 5'-phosphotransferase) 5 (1) 1 (1) 0000187 activation of MAPK activity 0046718 entry of virus into host CD81 antigen (26 kDa cell surface cell 13 45 -1.4 0005887 integral to plasma protein TAPA-1) (Target of the 0005515 protein binding 0006661 phosphatidylinositol P60033 25 1 PC 3 ±0.4 membrane antiproliferative antibody 1) biosynthesis 1 5 (3) (Tetraspanin-28) (Tspan-28) 0030384 phosphoinositide metabolism 0043128 posit

Eukaryotic initiation factor 4A-I (EC 36 124 -1.2 0005515 protein binding P60842 3.6.1.-) (ATP-dependent RNA helicase 18 2 PC 7 ±0.2

eIF4A-1) (eIF4A-I) (eIF-4A-I) 4 10 (10)

Proteasome subunit alpha type 6 (EC 3.4.25.1) (Proteasome iota chain) 14 28 -1.8 0005839 proteasome core 0004175 endopeptidase activity 0006511 ubiquitin-dependent (Macropain iota chain) (Multicatalytic P60900 16 1 PC 2 - complex 0005515 protein binding protein catabolism endopeptidase complex iota chain) (27 2 3 (1) 0003723 RNA binding kDa prosomal protein) (PROS-27) (p27K)

16 -3.8 18 -2.3 Destrin (Actin-depolymerizing factor) P60981 14 1 - 1 - (ADF) 3 (1) 1 (1)

63 -1.4 29 1.5

P61019 Ras-related protein Rab-2A 26 4 ±0.6 2 ±0.4

18 (3) 3 (3)

0051092 activation of NF-kappaB transcription factor IMP:HGNC Ubiquitin-conjugating enzyme E2 N (EC 0045739 positive regulation of 0005515 protein binding 6.3.2.19) (Ubiquitin-protein ligase N) 69 1.1 13 1.7 0005737 cytoplasm TAS:HGNC DNA repair IMP:HGNC 0043130 ubiquitin binding P61088 (Ubiquitin carrier protein N) (Ubc13) 42 5 ±0.1 1 - 0005634 nucleus 0043123 positive regulation of I- 0004840 ubiquitin conjugating (Bendless-like ubiquitin-conjugating 16 (3) 1 (1) 0031372 UBC13-MMS2 complex kappaB kinase/NF-k IMP:HGNC enzyme activity TAS:HGNC enzyme) 0016567 protein ubiquitination TAS:HGNC

Alpha-centractin (Centractin) 13 21 1.8 0005737 cytoplasm P61163 (Centrosome-associated actin homolog) 5 1 DC 1 ±0.5

(Actin-RPV) (ARP1) 1 3 (2)

Ras-related protein R-Ras2 (Ras-like 26 -3.4 11 30 -1.5 0005515 protein binding P62070 protein TC21) (Teratocarcinoma 20 2 - 1 2 ±0.1

oncogene) 6 (1) 1 3 (2)

0005843 cytosolic small ribosomal 61 -7.0 12 28 -1.4 0005515 protein binding subunit 0006412 protein biosynthesis P62081 40S ribosomal protein S7 29 5 ±1.6 1 2 - 0003735 structural constituent of 0005730 nucleolus 30 (2) 1 2 (1) ribosome 0005840 ribosome 53 72 -1.0 0005843 cytosolic small ribosomal 0003735 structural constituent of 0006412 protein biosynthesis P62249 40S ribosomal protein S16 44 4 PC 5 ±0.3 subunit ribosome

11 5 (2)

26S protease regulatory subunit S10B 95 1.5 34 -1.3 0006511 ubiquitin-dependent 0005634 nucleus 0016887 ATPase activity P62333 (Proteasome subunit p42) (Proteasome 27 6 ±0.3 2 - protein catabolism 0000502 proteasome complex 0030674 protein binding, bridging 26S subunit ATPase 6) 16 (4) 2 (1)

69 -2.1 38 -1.9 0003735 structural constituent of 0006610 ribosomal protein import 60S ribosomal protein L23 (Ribosomal 0005840 ribosome P62829 34 4 ±0.5 2 ±0.2 ribosome into nucleus protein L17) 15 (2) 3 (3)

35 6.7 12 -1.4 0005843 cytosolic small ribosomal 0003735 structural constituent of 0006412 protein biosynthesis P62861 40S ribosomal protein S30 20 3 - 1 - subunit ribosome

6 (1) 1 (1)

S-phase kinase-associated protein 1A (Cyclin A/CDK2-associated protein p19) 85 32 52 2.7 (p19A) (p19skp1) (RNA polymerase II 0005515 protein binding P63208 46 6 DC 2 3 ±0.2 elongation factor-like protein) (Organ of 13 4 6 (3) Corti protein 2) (OCP-II protein) (OCP- 2) (Transcription elongation factor B) (S Nuclease sensitive element-binding 0003677 DNA binding protein 1 (Y-box-binding protein 1) (Y- 0005515 protein binding box transcription factor) (YB-1) 60 141 -1.9 0006355 regulation of 0005634 nucleus 0003723 RNA binding P67809 (CCAAT-binding transcription factor I 41 4 PC 8 ±0.2 transcription, DNA-dependent 0016564 transcriptional repressor subunit A) (CBF-A) (Enhancer factor I 8 14 (12) activity subunit A) (EFI-A) (DNA-binding protein

B) (DBPB) 0047042 3-alpha-hydroxysteroid Aldo-keto reductase family 1 member dehydrogenase (B-spe 0008206 bile acid metabolism C1 (EC 1.1.1.-) (20-alpha- 0004033 aldo-keto reductase 0015721 bile acid transport hydroxysteroid dehydrogenase) (EC 35 48 35 1.7 activity 0005829 cytosol 0030299 cholesterol absorption Q04828 1.1.1.149) (20-alpha-HSD) (Trans-1,2- 28 2 DC 3 2 - 0032052 bile acid binding 0042632 cholesterol homeostasis dihydrobenzene-1,2-diol 4 3 3 (1) 0047115 trans-1,2- 0007586 digestion dehydrogenase) (EC 1.3.1.20) (High- dihydrobenzene-1,2-diol 0006118 affinity hepatic bile acid-binding protei dehydroge

Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 0006112 energy reserve 42 12 112 2.1 0004360 glutamine-fructose-6- 2.6.1.16) (Hexosephosphate metabolism Q06210 21 3 DC 1 8 ±0.2 phosphate transaminase aminotransferase 1) (D-fructose-6- 0006002 fructose 6-phosphate 8 1 9 (5) phosphate amidotransferase 1) (GFAT metabolism 1) (GFAT1)

20 1.1 47 -1.6 Protein phosphatase type 1 catalytic 0016787 hydrolase activity Q07161 14 1 - 3 ±0.3 subunit 0005506 iron ion binding 5 (1) 4 (3) 33 6.0 13 82 1.8

Q0V924 Valosin-containing protein 12 2 ±1.8 1 6 ±0.4

10 (2) 1 8 (3)

38 -10.4 22 -1.5 0030530 heterogeneous nuclear Heterogeneous nuclear 0003723 RNA binding 0006397 mRNA processing Q13151 11 2 - 1 - ribonucleoprotein com ribonucleoprotein A0 (hnRNP A0) 5 (1) 2 (1) 0005634 nucleus

Transcription intermediary factor 1-beta 0005515 protein binding (TIF1-beta) (Tripartite motif-containing 60 1.2 77 -2.2 0003714 transcription corepressor 0006357 regulation of transcription protein 28) (Nuclear corepressor KAP- Q13263 11 4 ±0.2 5 - activity from RNA polyme 1) (KRAB-associated protein 1) (KAP-1) 12 (3) 6 (1) 0003700 transcription factor (KRAB-interacting protein 1) (KRIP-1) activity (RING finger protein 96)

0006355 regulation of Heterogeneous nuclear 50 -2.9 10 68 -2.0 0003723 RNA binding 0005634 nucleus transcription, DNA-dependent Q14103 ribonucleoprotein D0 (hnRNP D0) (AU- 12 3 ±1.5 1 4 ±0.5 0016563 transcriptional activator 0006401 RNA catabolism rich element RNA-binding protein 1) 15 (2) 1 8 (6) activity 0006396 RNA processing

0005938 cell cortex 0005737 cytoplasm 18 44 1.6 Src substrate cortactin (Amplaxin) 0005856 cytoskeleton 0005515 protein binding Q14247 12 1 PC 3 ±0.4 (Oncogene EMS1) 0030027 lamellipodium 2 4 (3) 0001726 ruffle 0005625 soluble fraction

158 1.1 17 -1.2 0006355 regulation of 0000785 chromatin 0003677 DNA binding Q14321 HMG-1 27 10 - 1 - transcription, DNA-dependent 0005634 nucleus 37 (1) 1 (1)

UDP-glucose 4-epimerase (EC 5.1.3.2) 81 1.2 30 2.9

Q14376 (Galactowaldenase) (UDP-galactose 4- 27 5 ±0.4 2 ±1.2

epimerase) 12 (3) 2 (2)

Neutral alpha-glucosidase AB precursor 28 16 2.0 0005515 protein binding Q14697 (EC 3.2.1.84) (Glucosidase II subunit 6 2 DC 1 ±0.1

alpha) 3 3 (2)

16 40 2.8 0030864 cortical actin 0030865 cortical cytoskeleton LIM and SH3 domain protein 1 (LASP- 0015075 ion transporter activity Q14847 16 1 DC 3 ±1.2 cytoskeleton organization and biog 1) (MLN 50) 0005070 SH3/SH2 adaptor activity 2 3 (2) 0006811 ion transport

0008139 nuclear localization 0006607 NLS-bearing substrate Importin beta-1 subunit (Karyopherin 145 1.1 13 52 1.4 0005737 cytoplasm sequence binding import into nucleus Q14974 beta-1 subunit) (Nuclear factor P97) 18 10 ±0.2 1 3 ±0.2 0005643 nuclear pore 0005515 protein binding 0000060 protein import into (Importin 90) 16 (4) 1 7 (6) 0008270 zinc ion binding nucleus, translocation 38 37 -1.1 ELAV-like protein 1 (Hu-antigen R) 0042802 identical protein binding 0007275 development Q15717 19 3 PC 2 ±0.0 (HuR) 0003729 mRNA binding 5 2 (2)

Sterol-4-alpha-carboxylate 3- 14 17 1.6 0003854 3-beta-hydroxy-delta5- 0005783 endoplasmic reticulum 0006695 cholesterol biosynthesis Q15738 dehydrogenase, decarboxylating (EC 8 1 DC 1 ±0.5 steroid dehydrogenase

1.1.1.170) (H105e3 protein) 2 2 (2)

Neutral amino acid transporter B(0) (ATB(0)) (Sodium-dependent neutral 38 41 132 -1.5 0005887 integral to plasma 0015175 neutral amino acid 0015804 neutral amino acid Q15758 amino acid transporter type 2) 21 3 PC 3 8 ±0.2 membrane transporter activity transport (RD114/simian type D retrovirus 13 3 13 (9) 0005624 membrane fraction 0004872 receptor activity receptor) (Baboon M7 virus receptor)

Mitochondrial import receptor subunit 18 17 1.3 0016021 integral to membrane 0006626 protein targeting to 0005515 protein binding Q15785 TOM34 (Translocase of outer 9 1 PC 1 - 0005741 mitochondrial outer mitochondrion 0005048 signal sequence binding membrane 34 kDa subunit) (hTom34) 2 1 (1) membrane

14 14 1.3 0000074 regulation of progression

Q2TU96 Cyclin Y 4 1 DC 1 - through cell cycle

2 1 (1)

127 12.1 86 3.6 Biliverdin reductase B (Flavin reductase 0050662 coenzyme binding 0044237 cellular metabolism Q32LZ2 61 7 ±2.1 5 ±0.7 (NADPH)) 0016491 oxidoreductase activity 36 (3) 7 (6)

0005524 ATP binding 0016301 kinase activity 48 1.1 14 45 2.0 0004550 nucleoside diphosphate 0006241 CTP biosynthesis

Q32Q12 NME1-NME2 protein 30 4 - 1 3 ±0.7 kinase activity 0006183 GTP biosynthesis

13 (1) 1 3 (3) 0000166 nucleotide binding 0006228 UTP biosynthesis 0016740 transferase activity

0005524 ATP binding 0005737 cytoplasm 0016787 hydrolase activity 26 1.3 83 1.1 0005829 cytosol 0017111 nucleoside- 0030163 protein catabolism Q3B757 PSMC3 protein (Fragment) 15 2 - 5 ±0.1 0005634 nucleus triphosphatase activity 7 (1) 9 (5) 0043234 protein complex 0000166 nucleotide binding

78 40 -1.6 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q3KQT6 Ribosomal protein S2 25 5 PC 3 ±0.1 ribosome 0015935 small ribosomal subunit 10 5 (4)

157 8.6 85 3.6 0016491 oxidoreductase activity 0008152 metabolism Q3LHW8 Carbonyl reductase 1 51 10 - 5 ±1.1

31 (1) 6 (4) 26 23 4.8 Dihydroxyacetone kinase (EC 2.7.1.29) Q3LXA3 5 2 DC 1 - (Glycerone kinase) (DHA kinase) 2 1 (1)

24 -2.0 41 -2.0 0019843 rRNA binding 0005622 intracellular 0006412 protein biosynthesis Q498Y6 RPS11 protein 22 2 - 3 ±0.5 0003735 structural constituent of 0005840 ribosome 7 (1) 3 (2) ribosome

90 8.3 14 43 2.3

Q4JM47 AGR2 37 5 ±3.6 1 3 ±1.1

21 (3) 1 4 (2)

19 -2.2 48 2.2

Q4KMQ2 Transmembrane protein 16F 5 1 - 3 ±0.1

3 (1) 4 (2)

49 1.3 21 88 1.4 0005524 ATP binding 0008152 metabolism Q4LE36 ACLY variant protein (Fragment) 8 4 ±0.6 1 6 ±0.3 0003824 catalytic activity 9 (2) 1 10 (6)

0006461 protein complex assembly 133 -1.1 34 1.5 0005905 coated pit 0030276 clathrin binding 0006898 receptor mediated Q4LE54 PICALM variant protein (Fragment) 21 9 ±0.1 2 ±0.2 endocytosis 29 (5) 5 (5) 0016192 vesicle-mediated transport

42 64 1.0 0016459 myosin 0005524 ATP binding Q4LE56 MYO1C variant protein (Fragment) 6 3 PC 4 ±0.2 0003774 motor activity 5 7 (6)

84 10.9 30 1.2 0016020 membrane 0004872 receptor activity 0007155 cell adhesion Q52LZ5 Scavenger receptor class B, member 1 13 6 - 2 ±0.0

14 (1) 3 (2)

23 -3.8 43 1.3 Proteasome 26S non-ATPase subunit 0005829 cytosol 0005488 binding Q53FT5 13 2 - 3 ±0.1 11 variant (Fragment) 0043234 protein complex 4 (1) 3 (2)

52 -3.0 51 1.3 0005829 cytosol 0004298 threonine endopeptidase 0006511 ubiquitin-dependent Proteasome beta 1 subunit variant Q53FT8 24 3 ±0.7 3 ±0.2 0005839 proteasome core activity protein catabolism (Fragment) 11 (2) 5 (5) complex 23 19 -2.4 0005509 calcium ion binding

Q53FY2 Annexin A8 variant (Fragment) 12 2 PC 1 - 0005544 calcium-dependent

3 1 (1) phospholipid binding

46 13 31 -1.9 0003735 structural constituent of Ribosomal protein L19 variant 0005622 intracellular 0006412 protein biosynthesis Q53G49 13 3 PC 1 2 ±0.4 ribosome (Fragment) 0005840 ribosome 9 1 4 (3)

Full-length cDNA 5-PRIME end of clone 46 2.8 32 1.6

Q53GF9 CS0DF013YM24 of Fetal brain of Homo 21 4 ±1.0 2 ±0.1

sapiens (Human) variant (Fragment) 10 (2) 2 (2)

71 -2.2 54 1.0 Proteasome 26S non-ATPase subunit 0005829 cytosol Q53GN6 28 5 - 4 ±0.2 13 isoform 1 variant (Fragment) 0043234 protein complex 9 (1) 5 (3)

59 86 2.4 0017039 dipeptidyl-peptidase III Dipeptidylpeptidase III isoform 1 variant 0005737 cytoplasm 0006508 proteolysis Q53GT4 15 4 DC 5 ±0.4 activity (Fragment) 5 10 (7)

113 -1.1 15 105 2.1 0005515 protein binding Q53QM2 Hypothetical protein ACTR3 36 7 ±0.2 1 6 ±0.3

17 (4) 2 12 (6)

22 221 3.4 0051016 barbed-end actin Hypothetical protein SPTBN1 0003779 actin binding Q53R99 10 2 DC 14 ±0.4 filament capping (Fragment) 3 15 (8)

73 16 59 2.7 0004034 aldose 1-epimerase 0006012 galactose metabolism Q53RY1 Hypothetical protein LOC130589 28 4 DC 1 4 ±0.5 activity

10 1 4 (2)

41 1.5 22 1.4 0005509 calcium ion binding Q53X45 Myosin regulatory light chain 29 3 - 2 -

5 (1) 2 (1)

0004197 cysteine-type 16 4.9 55 2.2 endopeptidase activity 0006464 protein modification Ubiquitin specific protease 14 (TRNA- Q53XY5 10 1 - 3 ±1.0 0008233 peptidase activity 0006511 ubiquitin-dependent guanine transglycosylase) 3 (1) 3 (2) 0004221 ubiquitin thiolesterase protein catabolism activity

0030036 actin cytoskeleton 61 -1.2 18 3.5 0015629 actin cytoskeleton 0003779 actin binding organization and biogenesis Q53Y44 Profilin 1 (PFN1 protein) 40 4 ±0.0 1 ±0.3 0007010 cytoskeleton 17 (4) 3 (2) organization and biogenesis 80 2.2 34 1.3 0005829 cytosol 0004298 threonine endopeptidase 0006511 ubiquitin-dependent Proteasome (Prosome, macropain) Q53YE8 27 5 ±0.5 3 ±0.1 0005839 proteasome core activity protein catabolism subunit, alpha type, 1 16 (5) 4 (3) complex

14 1.9 16 -1.1 0004422 hypoxanthine 0009116 nucleoside metabolism Phosphoribosyl transferase domain 0005737 cytoplasm Q59EL9 5 1 - 1 - phosphoribosyltransferase acti 0006166 purine ribonucleoside containing 1 variant (Fragment) 4 (1) 1 (1) 0016740 transferase activity salvage

18 -1.4 13 1.3 Toll interacting protein variant Q59FB9 3 1 - 1 - (Fragment) 4 (1) 1 (1)

0030036 actin cytoskeleton 20 19 2.4 0003779 actin binding organization and biogenesis Q59FH8 Diaphanous 1 variant (Fragment) 3 1 DC 1 ±0.2 0017048 Rho GTPase binding 0016043 cell organization and 1 2 (2) biogenesis

93 1.8 14 38 3.4 Acetyl-CoA acetyltransferase, cytosolic 0016740 transferase activity Q59GW6 32 6 - 1 2 ±0.6 variant (Fragment) 23 (1) 1 4 (4)

49 26 112 -1.3 0003735 structural constituent of Ribosomal protein L4 variant 0005622 intracellular 0006412 protein biosynthesis Q59GY2 20 4 PC 2 7 ±0.2 ribosome (Fragment) 0005840 ribosome 7 2 9 (6)

67 53 17.3 0016868 intramolecular 0005975 carbohydrate metabolism Q5BKZ9 PGM1 protein (Fragment) 15 5 DC 3 ±9.3 transferase activity, phosph

9 5 (2)

37 47 -2.4 0016020 membrane 0016337 cell-cell adhesion Q5NKV8 Intercellular adhesion molecule 1 11 3 PC 3 ±0.2

5 3 (2)

S100 calcium binding protein A16 17 -3.0 27 1.0 0005509 calcium ion binding Q5RHS6 (Aging-associated protein 13) (S100A16 33 1 - 2 ±0.2

protein) (S100F) 10 (1) 3 (3)

37 -26.0 15 1.3 0005829 cytosol 0004298 threonine endopeptidase 0006511 ubiquitin-dependent Proteasome (Prosome, macropain) Q5SZS5 19 2 - 1 - 0005839 proteasome core activity protein catabolism subunit, beta type, 4 5 (1) 1 (1) complex

62 1.9 41 1.0 0005737 cytoplasm 0005488 binding 0000059 protein import into Q5T578 Karyopherin (Importin) beta 3 7 4 - 3 ±0.1 0005643 nuclear pore 0008565 protein transporter nucleus, docking 9 (1) 3 (2) 0005634 nucleus activity 29 104 -1.6 0003743 translation initiation Eukaryotic translation initiation factor 3, Q5T5X0 11 2 PC 6 ±0.1 factor activity subunit 10 theta, 150\/170kDa 5 6 (5)

78 -13.6 45 -2.8 0003735 structural constituent of 0006412 protein biosynthesis 0005622 intracellular Q5T8U4 Ribosomal protein L7a 19 5 - 3 ±0.2 ribosome 0042254 ribosome biogenesis and 0005840 ribosome 14 (1) 6 (4) assembly

38 3.5 14 3.4 0009055 electron carrier activity

Q5T937 Thioredoxin (TXN protein) 22 3 ±1.5 1 ±1.0 0015035 protein disulfide

11 (2) 2 (2) oxidoreductase activity

43 3.5 12 85 4.7 0005515 protein binding 0030163 protein catabolism Q5TGY0 F-box protein 2 25 3 - 1 5 ±1.0

8 (1) 1 10 (7)

0005524 ATP binding 0000166 nucleotide binding 12 20 -1.7 0006468 protein amino acid 0004674 protein serine/threonine Q5U5J2 CSNK2A1 protein 9 1 PC 1 ±0.2 phosphorylation kinase activity 1 2 (2) 0016740 transferase activity

30 -2.2 41 -1.5 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q5VVD0 Ribosomal protein L11 17 2 ±0.1 3 ±0.3 ribosome 0005840 ribosome 23 (2) 5 (3)

0008168 methyltransferase 56 1.3 29 1.4 activity Protein-L-isoaspartate (D-aspartate) O- 0006464 protein modification Q5VYC1 23 4 - 2 ±0.3 0004719 protein-L-isoaspartate methyltransferase 7 (1) 2 (2) (D-aspartate) O-meth 0016740 transferase activity

17 17 13.0 0016021 integral to membrane Q5VZP6 Glycoprotein A33 (Transmembrane) 10 1 DC 1 -

4 2 (1)

39 -1.2 14 48 1.3 0006464 protein modification Q66K58 Hypothetical protein (Fragment) 45 3 - 1 3 ±0.3

70 (1) 2 6 (4)

18 -4.1 18 -1.4 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q6FG99 RPLP1 protein 14 1 - 1 ±0.3 ribosome 0005840 ribosome 0006414 translational elongation 8 (1) 2 (2) 75 1.5 13 1.7 0007517 muscle development Q6FGI1 TAGLN2 protein (Transgelin 2) 34 5 ±0.2 1 -

19 (5) 1 (1)

19 1.4 16 2.1 0005488 binding 0006886 intracellular protein 0005783 endoplasmic reticulum Q6FHY4 NAPG protein 5 1 - 1 - 0005478 intracellular transporter transport 0005794 Golgi apparatus 5 (1) 1 (1) activity

44 32 2.3 ADFP protein (Adipose differentiation- Q6FHZ7 14 3 DC 2 ±0.6 related protein) 5 2 (2)

46 11 1.3 RSU1 protein (Ras suppressor protein 0016740 transferase activity Q6FI17 19 4 PC 1 - 1) 7 1 (1)

F11R protein (CDNA FLJ90671 fis, 30 -1.6 33 1.1 clone PLACE1005544, highly similar to 0016021 integral to membrane 0004872 receptor activity Q6FIB4 11 2 ±0.3 2 ±0.0 Junctional adhesion molecule 1) (JAM1) 16 (2) 4 (4) (F11 receptor protein)

AKR1A1 protein (Aldo-keto reductase 56 10.9 47 2.3 0016491 oxidoreductase activity Q6IAZ4 family 1, member A1) (Aldehyde 19 4 - 3 ±0.5

reductase) 7 (1) 4 (3)

ATP6V1G1 protein (ATPase, H+ 17 12 1.8

Q6IB33 transporting, lysosomal 13kDa, V1 9 1 PC 1 -

subunit G isoform 1) 1 1 (1)

26 1.2 30 1.7 0005829 cytosol 0004298 threonine endopeptidase 0006511 ubiquitin-dependent Proteasome subunit alpha type (EC Q6IB71 11 2 ±0.1 2 ±0.3 0005839 proteasome core activity protein catabolism 3.4.25.1) 11 (2) 3 (3) complex

28 1.5 15 4.5 0005094 Rho GDP-dissociation ARHGDIA protein (Rho GDP 0005737 cytoplasm Q6IBM5 12 2 - 1 - inhibitor activity dissociation inhibitor (GDI) alpha) 5 (1) 2 (1)

104 -14.8 29 -1.1 0003723 RNA binding Ribosomal protein S4, X-linked (RPS4X 0005622 intracellular 0006412 protein biosynthesis Q6IPY4 37 7 - 2 ±0.0 0003735 structural constituent of protein) 0005840 ribosome 21 (1) 3 (2) ribosome

48 94 -1.7 0000398 nuclear mRNA splicing, 0005634 nucleus 0000166 nucleotide binding Q6NTA2 HNRPL protein 25 3 PC 6 ±0.2 via spliceosome 0003723 RNA binding 11 10 (5) 13 43 -2.9 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q6NZ52 Ribosomal protein L27a 22 1 PC 3 ±0.3 ribosome 0005840 ribosome 3 5 (3)

76 -3.6 32 -2.4 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q6NZ54 Ribosomal protein L17 28 5 ±0.6 2 - ribosome 0015934 large ribosomal subunit 16 (2) 3 (1)

31 -1.0 12 -2.3 0005838 proteasome regulatory 0006508 proteolysis Q6P1L7 Hypothetical protein (Fragment) 13 2 ±0.2 1 - particle (sensu Eukar

12 (2) 1 (1)

146 -5.8 32 -1.4 0004139 deoxyribose-phosphate 0009264 deoxyribonucleotide Q6PHW 0005737 cytoplasm DERA protein (Fragment) 42 9 ±1.0 2 ±0.0 aldolase activity catabolism 2 37 (5) 2 (2) 0016829 lyase activity

14 18 -1.4

Q6V708 RNA export 1-like protein 4 1 PC 1 -

1 1 (1)

13 14 14 3.7 CDNA FLJ42222 fis, clone Q6ZVQ2 15 1 DC 1 1 ±1.1 THYMU2039411 1 2 2 (2)

0030601 aminopeptidase B 18 110 1.7 activity 0006508 proteolysis Q7RU04 Aminopeptidase B (EC 3.4.11.6) 15 2 DC 7 ±0.3 0016787 hydrolase activity

2 7 (2) 0004179 membrane alanyl aminopeptidase activity

23 -2.2 78 1.4 0005839 proteasome core 0004298 threonine endopeptidase 0006511 ubiquitin-dependent Hypothetical protein DKFZp686I0180 Q7Z3B5 29 2 - 5 ±0.2 complex activity protein catabolism (Fragment) 6 (1) 8 (8)

0007155 cell adhesion 0007160 cell-matrix adhesion 85 -1.1 14 -2.0 0016021 integral to membrane 0005515 protein binding 0007275 development Q7Z3V1 Integrin beta (Fragment) 9 6 - 1 - 0008305 integrin complex 0007229 integrin-mediated 9 (1) 1 (1) signaling pathway

25 16 2.0 Eukaryotic initiation factor 5A isoform I 0005515 protein binding Q7Z4L1 26 2 PC 1 - variant A 5 1 (1) THO complex subunit 4 (Tho4) (Ally of 24 16 -1.6 AML-1 and LEF-1) (Transcriptional 0005515 protein binding Q86V81 11 2 PC 1 - coactivator Aly/REF) (bZIP-enhancing 2 1 (1) factor BEF)

Splicing factor proline/glutamine-rich 57 28 -2.5 0000166 nucleotide binding Q86VG2 (Polypyrimidine tract binding protein 7 4 PC 2 ±1.1 0003723 RNA binding associated) 8 3 (2)

37 -3.7 15 1.5

Q8IVL4 Hypothetical protein 13 3 - 1 -

6 (1) 1 (1)

56 14 20 -1.8 CDNA FLJ34582 fis, clone Q8NAX9 17 4 PC 1 1 - KIDNE2008649 7 1 3 (1)

27 -3.7 14 48 -1.5 0003735 structural constituent of 0005622 intracellular 0006412 protein biosynthesis Q8WTY3 RPL27 protein 35 2 - 1 3 ±0.1 ribosome 0005840 ribosome 6 (1) 1 4 (4)

43 -2.3 15 1.1 LAMP1 protein (Lysosomal-associated 0016020 membrane Q8WU33 8 3 - 1 - membrane protein 1) 16 (1) 1 (1)

Protein phosphatase 2 (Formerly 2A), 43 -1.7 13 26 1.4 0005488 binding Q96DH3 regulatory subunit A (PR 65), alpha 12 3 - 1 2 -

isoform 9 (1) 1 2 (1)

17 3.4 34 2.2 0016805 dipeptidase activity 0006508 proteolysis Q96FV2 Secernin 2 16 1 - 2 ±0.4

3 (1) 3 (3)

Ubiquitin thioesterase protein OTUB1 (EC 3.4.-.-) (Otubain-1) (OTU domain- 40 13 57 2.2 containing ubiquitin aldehyde-binding Q96FW1 27 3 DC 1 4 ±0.5 protein 1) (Ubiquitin-specific-processing 5 1 6 (4) protease OTUB1) (Deubiquitinating enzyme OTUB1)

13 -3.3 11 -1.3 Vacuolar sorting protein SNF8 (ELL- Q96H20 4 1 - 1 - associated protein of 30 kDa) 5 (1) 1 (1) EEF1D protein (Eukaryotic translation 76 1.0 16 65 -2.1 0043123 positive regulation of I- 0004871 signal transducer activity Q96I38 elongation factor 1 delta) (Guanine 11 5 ±0.2 1 4 ±0.4 kappaB kinase/NF-k

nucleotide exchange protein) 24 (3) 1 7 (4)

29 18 1.2 Abhydrolase domain-containing protein Q96IU4 15 2 DC 1 - 14B (CCG1-interacting factor B) 4 1 (1)

35 1.2 20 3.6 0005856 cytoskeleton 0005524 ATP binding Q96JP2 KIAA1783 protein (Fragment) 2 2 ±0.2 1 - 0016459 myosin 0003774 motor activity 8 (2) 1 (1)

Vacuolar protein sorting 35 (Vesicle 134 2.0 12 144 -1.1 0042147 retrograde transport, 0005829 cytosol 0005515 protein binding Q96QK1 protein sorting 35) (hVPS35) (Maternal- 18 9 ±0.5 1 10 ±0.2 endosome to Golgi 0005768 endosome embryonic 3) 43 (8) 2 13 (7)

Nucleosome assembly protein 1-like 4 39 14 64 1.2 0005678 chromatin assembly 0051082 unfolded protein binding 0006334 nucleosome assembly Q99733 (Nucleosome assembly protein 2) 13 3 PC 1 4 ±0.4 complex

(NAP2) 3 1 8 (3) 0005737 cytoplasm

0030057 desmosome 46 63 -1.4 0016021 integral to membrane 0016337 cell-cell adhesion Q99959 Plakophilin-2 15 3 PC 4 ±0.1 0005634 nucleus

3 4 (3) 0005886 plasma membrane

Actin related protein 2/3 complex, 35 -1.8 16 1.5 0030833 regulation of actin 0005856 cytoskeleton Q9BPX5 subunit 5-like (Actin related protein 2\/3 16 2 ±0.2 1 - filament polymerization

complex, subunit 5-like) 9 (2) 1 (1)

0005524 ATP binding 28 131 -1.2 0006432 phenylalanyl-tRNA 0005737 cytoplasm 0016874 ligase activity Q9BR63 FARSLB protein (Fragment) 21 2 PC 9 ±0.2 aminoacylation 0004826 phenylalanine-tRNA 2 10 (7) ligase activity

36 1.0 15 35 -1.3 0016192 vesicle-mediated Vesicle-associated membrane protein 3 0016021 integral to membrane Q9BRV4 33 2 - 1 2 ±0.3 transport (Cellubrevin) 13 (1) 1 6 (4)

32 11.9 16 -1.2 0005694 chromosome 0007001 chromosome 0003677 DNA binding Q9BTM1 H2A histone family, member J 30 2 ±4.2 1 - 0000786 nucleosome organization and biogenesis (sen

15 (2) 1 (1) 0005634 nucleus 0006334 nucleosome assembly

72 35 1.1 0000398 nuclear mRNA splicing, 0005634 nucleus 0000166 nucleotide binding Q9BUQ0 Polypyrimidine tract binding protein 1 18 5 PC 2 ±0.1 via spliceosome 0003723 RNA binding 10 3 (2) Transmembrane emp24 domain- 76 -1.0 14 2.1 0005793 ER-Golgi intermediate

Q9BVK6 containing protein 9 precursor 29 5 ±0.3 1 - compartment

(Glycoprotein 25L2) 27 (4) 1 (1)

28 -2.2 17 -1.2 0005829 cytosol 0004298 threonine endopeptidase 0006511 ubiquitin-dependent Proteasome (Prosome, macropain) Q9BWZ9 12 2 ±0.7 1 - 0005839 proteasome core activity protein catabolism subunit, beta type, 2 (PSMB2 protein) 15 (2) 3 (1) complex

0007409 axonogenesis 0007163 establishment and/or maintenance of cell po 25 33 -1.1 Partitioning defective 6 homolog beta 0005886 plasma membrane 0005515 protein binding 0007043 intercellular junction Q9BYG5 6 2 PC 2 ±0.2 (PAR-6 beta) (PAR-6B) 0005923 tight junction assembly 2 3 (2) 0030334 regulation of cell migration

93 28.0 31 2.9 Mucin-13 precursor (Down-regulated in Q9H3R2 18 6 - 2 ±0.5 colon cancer 1) 27 (1) 2 (2)

48 1.1 29 -1.3 Golgi phosphoprotein 3 (Coat-protein Q9H4A6 19 3 ±0.3 2 - GPP34) 15 (3) 3 (1)

34 41 -2.4 0005515 protein binding Q9H568 Novel actin like protein 22 2 PC 3 ±0.1

2 4 (3)

Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal 85 1.1 93 2.6

Q9H6S3 growth factor receptor pathway 17 6 ±0.2 6 ±0.7

substrate 8-related protein 2) (EPS8- 10 (4) 8 (5) like protein 2)

45 -1.1 19 17 2.0 Protein S100-A14 (S100 calcium- Q9HCY8 44 3 - 1 1 ±0.3 binding protein A14) (S114) 6 (1) 1 5 (4)

Sialic acid synthase (N- acetylneuraminate synthase) (EC 2.5.1.56) (N-acetylneuraminic acid 13 3.1 13 36 2.7 0008781 N-acylneuraminate 0009103 lipopolysaccharide 0005737 cytoplasm Q9NR45 synthase) (N-acetylneuraminate-9- 8 1 - 1 2 ±0.5 cytidylyltransferase acti biosynthesis

phosphate synthase) (EC 2.5.1.57) (N- 2 (1) 1 4 (4) acetylneuraminic acid phosphate synthase)

37 36 3.1

Q9NRV9 Heme-binding protein 1 (p22HBP) 30 3 DC 2 ±0.3

9 2 (2) Lin-7 homolog C (Lin-7C) (Mammalian 63 -1.3 38 2.1 lin-seven protein 3) (MALS-3) Q9NUP9 35 5 ±0.7 3 ±0.9 (Vertebrate lin-7 homolog 3) (Veli-3 16 (2) 3 (2) protein)

Phosphoprotein associated with glycosphingolipid-enriched 14 76 3.2 Q9NWQ microdomains 1 (Transmembrane 18 1 DC 5 ±1.0 8 adapter protein PAG) (Csk-binding 2 6 (2) protein) (Transmembrane phosphoprotein Cbp)

Eukaryotic translation initiation factor 3 61 -5.9 13 -1.1 subunit 12 (eIF-3 p25) (eIF-3 p28) Q9UBQ5 22 4 ±2.1 1 - (eIF3k) (Muscle-specific gene M9 14 (2) 1 (1) protein) (ARG134) (PLAC-24)

14 64 3.0 0007015 actin filament 0015629 actin cytoskeleton 0005522 profilin binding Q9UFZ5 Hypothetical protein DKFZp434D064 13 1 DC 4 ±0.9 organization 0005886 plasma membrane 1 5 (4)

Protein kinase C and casein kinase 17 50 1.5 0008092 cytoskeletal protein 0045806 negative regulation of substrate in neurons protein 3 (SH3 0005737 cytoplasm Q9UKS6 13 1 DC 3 ±0.2 binding endocytosis domain-containing protein 6511) 1 6 (3) 0019899 enzyme binding (Endophilin I)

Brain-specific angiogenesis inhibitor 1- associated protein 2 (BAI1-associated protein 2) (BAI-associated protein 2) 18 2.1 64 -1.9 0005515 protein binding Q9UQB8 (Protein BAP2) (Insulin receptor 16 1 - 4 ±0.1

substrate p53) (IRSp53) (Insulin 4 (1) 4 (2) receptor substrate protein of 53 kDa) (Insulin rece 0030274 LIM domain binding 0005829 cytosol 0005515 protein binding 0006928 cell motility 38 -1.4 90 -1.4 0005925 focal adhesion ISS:HGNC 0007016 cytoskeletal anchoring Q9Y490 Talin-1 4 3 - 6 ±0.3 0005911 intercellular junction 0005200 structural constituent of 0007043 intercellular junction 4 (1) 7 (5) 0001726 ruffle cytoskeleton assembly 0017166 vinculin binding

HSPC039 protein (Immediate early 21 15 -1.1 response 3 interacting protein 1) 0005783 endoplasmic reticulum Q9Y5U9 24 1 DC 1 - (Hypothetical protein DKFZp564B1471) 1 2 (1) (Hypothetical transmembrane protein)

14 2.1 150 kDa oxygen-regulated protein (150 0005524 ATP binding Q2I204 1 1 - kDa oxygen-regulated protein variant 1) 1 (1)

26.3 12 12 ±11. Q3KR05 Sialidase 4 1 1 1 8 3 3 (3) 0005507 copper ion binding 20 2.8 13 0005506 iron ion binding 0006811 ion transport Q5JUU0 Hephaestin 1 1 - 1 0046872 metal ion binding 0006826 iron ion transport 1 (1) 1 0016491 oxidoreductase activity

12 35 2.1 55 Acyl-CoA synthetase long-chain family 0003824 catalytic activity 0008152 metabolism Q5JV16 10 1 2 - 4 member 4 4 3 (1) 4

18 -1.9 12 CD63 antigen (Melanoma 1 antigen) 0016021 integral to membrane Q5TZP3 4 1 ±0.1 1 (CD63 protein) 4 (4) 2

0007242 intracellular signaling 10 1.2 11 0005524 ATP binding cascade Q86XJ6 Protein kinase C, delta 3 1 - 1 0004674 protein serine/threonine 0006468 protein amino acid 1 (1) 1 kinase activity phosphorylation

13 2.3 Polycystic kidney disease 1-like 1 0016020 membrane 0016337 cell-cell adhesion Q8TDX9 0 1 - protein (Polycystin-1L1) 2 (1)

13 -1.3 0003743 translation initiation Eukaryotic translation initiation factor 3, Q8WVK4 2 1 - factor activity subunit 6 48kDa 1 (1)

Histone deacetylase complex subunit 13 0000118 histone deacetylase 0005515 protein binding 0006357 regulation of transcription SAP18 (Sin3-associated polypeptide, O00422 10 1 PC complex 0003714 transcription corepressor from RNA polyme 18 kDa) (Sin3-associated polypeptide 4 activity p18) (2HOR0202)

0030139 endocytic vesicle 13 14 0005801 Golgi cis face

O00461 130 kD Golgi-localized phosphoprotein 4 1 DC 1 0005796 Golgi lumen

1 1 0016021 integral to membrane

0008093 cytoskeletal adaptor 0030036 actin cytoskeleton 0005912 adherens junction activity organization and biogenesis Syntenin-1 (Syndecan-binding protein 0005856 cytoskeleton 0005137 interleukin-5 receptor 0007242 intracellular signaling 1) (Melanoma differentiation-associated 67 0005895 interleukin-5 receptor binding cascade protein 9) (MDA-9) (Scaffold protein O00560 23 4 PC complex 0042043 neurexin binding 0006612 protein targeting to Pbp1) (Pro-TGF-alpha cytoplasmic 8 0016020 membrane 0046982 protein membrane domain-interacting protein 18) 0005634 nucleus heterodimerization activity 0006930 substrate-bound cell (TACIP18) 0045545 syndecan bi migration, cell extensio

29 1.7 Pyridoxal kinase (EC 2.7.1.35) 0008478 pyridoxal kinase activity O00764 9 2 - (Pyridoxine kinase) 4 (1) Programmed cell death protein 5 27 1.1 0006917 induction of apoptosis O14737 (Protein TFAR19) (TF-1 cell apoptosis- 19 2 -

related gene 19 protein) 6 (1)

0004177 aminopeptidase activity 0045453 bone resorption Tripeptidyl-peptidase 1 precursor (EC 0004175 endopeptidase activity 0006629 lipid metabolism 3.4.14.9) (Tripeptidyl-peptidase I) (TPP- 0005515 protein binding 0007399 nervous system 13 I) (Tripeptidyl aminopeptidase) 0005764 lysosome 0008236 serine-type peptidase development O14773 4 1 DC (Lysosomal pepstatin insensitive 0005625 soluble fraction activity 0043171 peptide catabolism 1 protease) (LPIC) (Growth-inhibiting 0019131 tripeptidyl-peptidase I 0045862 positive regulation of gene 1 protein) activit proteolysis

14 0005737 cytoplasm Exportin-1 (Exp1) (Chromosome region 0005515 protein binding O14980 1 1 DC 0005635 nuclear envelope maintenance 1 protein homolog) 1 0005654 nucleoplasm

Membrane-associated progesterone 24 -1.4 0005496 steroid binding receptor component 2 (Progesterone 0016021 integral to membrane O15173 14 2 ±0.1 0003707 steroid hormone receptor membrane-binding protein) (Steroid 4 (2) activity receptor protein DG6)

High mobility group protein B3 (High 32 -1.3 0008301 DNA bending activity 0007275 development O15347 mobility group protein 4) (HMG-4) (High 13 2 -

mobility group protein 2a) (HMG-2a) 9 (1)

34 1.2 0006892 post-Golgi vesicle-

O15400 Syntaxin-7 11 2 ±0.5 mediated transport

10 (2)

Aflatoxin B1 aldehyde reductase 26 0004032 aldehyde reductase 0006081 aldehyde metabolism O43488 member 2 (EC 1.-.-.-) (AFB1-AR 1) 9 2 DC activity 0005975 carbohydrate metabolism (Aldoketoreductase 7) 5 0009055 electron carrier activity

34 7.4 0005634 nucleus 0008283 cell proliferation O43598 c-Myc-responsive protein Rcl 10 2 -

5 (1)

15 13 Trafficking protein particle complex O43617 14 1 DC 1 subunit 3 (BET3 homolog) 1 1

0030136 clathrin-coated vesicle 17 0005769 early endosome 0005515 protein binding 0006906 vesicle fusion O43752 Syntaxin-6 4 1 PC 0048471 perinuclear region

2 0005886 plasma membrane

Cleavage and polyadenylation specificity factor 5 (Cleavage and polyadenylation specificity factor 25 kDa 84 -5.5 0005813 centrosome 0005515 protein binding 0006397 mRNA processing O43809 subunit) (CPSF 25 kDa subunit) (Pre- 31 5 - 0042382 paraspeckles mRNA cleavage factor Im 25 kDa 10 (1) subunit) (Nucleoside diphosphate-linked moiety X motif 21) ( Xaa-Pro aminopeptidase 2 precursor (EC 3.4.11.9) (X-Pro aminopeptidase 2) 56 (Membrane-bound aminopeptidase P) 0016020 membrane 0004177 aminopeptidase activity O43895 9 4 DC (Membrane-bound APP) (Membrane- 4 bound AmP) (mAmP) (Aminoacylproline aminopeptidase) 0000244 assembly of FUS-interacting serine-arginine-rich spliceosomal tri-snRNP protein 1 (TLS-associated protein with 0016482 cytoplasmic transport 0031202 RNA splicing factor Ser-Arg repeats) (TLS-associated 15 0005737 cytoplasm 0006406 mRNA export from activity, transesterifi O75494 protein with SR repeats) (TASR) (TLS- 6 1 PC 0005654 nucleoplasm nucleus 0050733 RS domain binding associated serine-arginine protein) 3 0005634 nucleus 0006376 mRNA splice site 0051082 unfolded protein binding (TLS-associated SR protein) (40 kDa selection SR-repressor pr 0048025 negative regulat

41 -1.0 22 Barrier-to-autointegration factor 0009615 response to virus O75531 40 2 ±0.3 1 (Breakpoint cluster region protein 1) 6 (2) 1

Thioredoxin-like protein 2 (PKC- 57 1.4 30 interacting cousin of thioredoxin) (PKC- 0005515 protein binding O76003 19 4 ±0.5 2 theta-interacting protein) (PKCq- 9 (2) 2 interacting protein)

SNARE-associated protein Snapin 0006886 intracellular protein 16 (Synaptosomal-associated protein 25- 0008021 synaptic vesicle 0000149 SNARE binding transport O95295 10 1 DC binding protein) (SNAP-associated 0007269 neurotransmitter 1 protein) secretion

0001671 ATPase stimulator 15 13 activity Activator of 90 kDa heat shock protein 0005737 cytoplasm 0006457 protein folding O95433 6 1 PC 1 0030189 chaperone activator ATPase homolog 1 (AHA1) (p38) 0006950 response to stress 4 1 activity 0051087 chaperone binding AP-2 complex subunit alpha-1 (Adapter- related protein complex 2 alpha-1 0006897 endocytosis subunit) (Alpha-adaptin A) (Adaptor 50 2.0 0030122 AP-2 adaptor complex 0006895 Golgi to endosome

O95782 protein complex AP-2 alpha-1 subunit) 4 3 ±0.9 0030130 clathrin coat of trans- transport

(Clathrin assembly protein complex 2 13 (2) Golgi network vesicle 0006886 intracellular protein alpha-A large chain) (100 kDa coated transport vesicle prote

BAG family molecular chaperone 27 14 0030188 chaperone regulator 0006457 protein folding O95816 regulator 2 (BCL2-associated 15 2 PC 1 activity 0019538 protein metabolism athanogene 2) (BAG-2) 5 1 33 1.3 0005887 integral to plasma 0016338 calcium-independent Claudin-1 (Senescence-associated 0042802 identical protein binding O95832 14 2 ±0.5 membrane cell-cell adhesion epithelial membrane protein) 11 (2) 0005923 tight junction 0007155 cell adhesion

3'(2'),5'-bisphosphate nucleotidase 1 0007399 nervous system 30 10 0008441 3'(2'),5'-bisphosphate (EC 3.1.3.7) (Bisphosphate 3'- development O95861 16 2 DC 1 nucleotidase activity nucleotidase 1) (PAP-inositol-1,4- 0006139 nucleobase, nucleoside, 4 1 phosphatase) (PIP) nucleotide and nucl

13 -3.0 0004146 dihydrofolate reductase 0006545 glycine biosynthesis P00374 Dihydrofolate reductase (EC 1.5.1.3) 8 1 - activity 0009165 nucleotide biosynthesis 3 (1)

0007166 cell surface receptor linked signal transdu GTPase HRas precursor (Transforming 38 2.0 30 0008022 protein C-terminus 0006935 chemotaxis 0005737 cytoplasm P01112 protein p21) (p21ras) (H-Ras-1) (c-H- 33 3 ±1.0 2 binding 0009887 organ morphogenesis 0005886 plasma membrane ras) 9 (2) 2 0000074 regulation of progression through cell cycle NAS:ProtInc

0001315 age-dependent response to reactive oxygen s 0006357 regulation of transcription 14 2.8 0008383 manganese superoxide from RNA polyme Superoxide dismutase [Mn], 0005739 mitochondrion P04179 6 1 - dismutase activity 0006979 response to oxidative mitochondrial precursor (EC 1.15.1.1) 3 (1) stress 0000303 response to superoxide TAS:UniPr

0006916 anti-apoptosis Heat-shock protein beta-1 (HspB1) 0006928 cell motility (Heat shock 27 kDa protein) (HSP 27) 18 0009986 cell surface 0006446 regulation of translational 0005515 protein binding P04792 (Stress-responsive protein 27) (SRP27) 15 1 PC 0005737 cytoplasm initiation

(Estrogen-regulated 24 kDa protein) (28 1 0005856 cytoskeleton 0006986 response to unfolded kDa heat shock protein) protein

Lupus La protein (Sjoegren syndrome 14 1.5 16 0030529 ribonucleoprotein 0008334 histone mRNA 0003729 mRNA binding P05455 type B antigen) (SS-B) (La 7 1 - 1 complex metabolism 0000049 tRNA binding ribonucleoprotein) (La autoantigen) 4 (1) 1 0006400 tRNA modification

Protein S100-A9 (S100 calcium-binding protein A9) (Calgranulin-B) (Migration 17 0005509 calcium ion binding 0007267 cell-cell signaling P06702 inhibitory factor-related protein 14) 13 1 PC 0004871 signal transducer activity 0006954 inflammatory response (MRP-14) (P14) (Leukocyte L1 complex 3 heavy chain) (Calprotectin L1H subunit)

18 Fatty acid-binding protein, liver (L- 0009887 organ morphogenesis P07148 19 2 PC FABP) 2 28 14 0005843 cytosolic small ribosomal 0003723 RNA binding 0006412 protein biosynthesis P08708 40S ribosomal protein S17 32 2 PC 1 subunit 0003735 structural constituent of

6 1 ribosome

Dihydropteridine reductase (EC 19 0004155 6,7-dihydropteridine 0006520 amino acid metabolism 0005737 cytoplasm P09417 1.5.1.34) (HDHPR) (Quinoid 6 1 DC reductase activity 0051066 dihydrobiopterin

dihydropteridine reductase) 2 0009055 electron carrier activity metabolism

19 0016023 cytoplasmic membrane- S-formylglutathione hydrolase (EC 0004759 serine esterase activity P10768 8 1 DC bound vesicle 3.1.2.12) (FGH) (Esterase D) 1

0001525 angiogenesis 0016477 cell migration Carcinoembryonic antigen-related cell 87 0005887 integral to plasma 0007156 homophilic cell adhesion adhesion molecule 1 precursor (Biliary P13688 15 6 DC membrane 0007229 integrin-mediated glycoprotein 1) (BGP-1) (CD66 antigen) 9 0005624 membrane fraction signaling pathway (CD66a antigen) 0007565 pregnancy

Electron transfer flavoprotein subunit 13 0005759 mitochondrial matrix 0009055 electron carrier activity P13804 alpha, mitochondrial precursor (Alpha- 6 1 DC 0005739 mitochondrion ETF) 2

Replication protein A 32 kDa subunit 17 12 0005662 DNA replication factor A 0005515 protein binding 0006261 DNA-dependent DNA P15927 (RP-A) (RF-A) (Replication factor-A 10 1 PC 1 complex 0003697 single-stranded DNA replication protein 2) (p32) (p34) 3 1 binding

Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- 20 -1.5 0003677 DNA binding 0005634 nucleus 0006266 DNA ligation P16455 methylguanine-DNA methyltransferase) 8 1 - 0009008 DNA-methyltransferase

(MGMT) (O-6-methylguanine-DNA- 6 (1) activity alkyltransferase)

Aspartate aminotransferase, 153 -1.2 27 cytoplasmic (EC 2.6.1.1) 0006533 aspartate catabolism P17174 41 9 ±0.2 2 (Transaminase A) (Glutamate 41 (6) 2 oxaloacetate transaminase 1)

12 3.5 0003702 RNA polymerase II 0006366 transcription from RNA Transcription factor BTF3 (RNA P20290 9 1 - transcription factor acti polymerase II promoter polymerase B transcription factor 3) 4 (1)

5'-nucleotidase precursor (EC 3.1.3.5) 38 0005624 membrane fraction 0008253 5'-nucleotidase activity 0006259 DNA metabolism P21589 (Ecto-5'-nucleotidase) (5'-NT) (CD73 5 2 DC

antigen) 2 Voltage-dependent anion-selective 0015283 apoptogenic cytochrome channel protein 1 (VDAC-1) (hVDAC1) 13 0005741 mitochondrial outer c release channel ac 0006820 anion transport P21796 (Outer mitochondrial membrane protein 7 1 PC membrane 0015482 voltage-gated anion 0008632 apoptotic program porin 1) (Plasmalemmal porin) (Porin 1 0005739 mitochondrion channel porin activity 31HL) (Porin 31HM)

Integrin alpha-6 precursor (VLA-6) 22 0007044 cell-substrate junction

P23229 (CD49f antigen) [Contains: Integrin 2 2 PC assembly

alpha-6 heavy chain 2

Proteasome subunit alpha type 4 (EC 3.4.25.1) (Proteasome component C9) 12 14 0000502 proteasome complex P25789 (Macropain subunit C9) (Multicatalytic 13 1 DC 1

endopeptidase complex subunit C9) 2 1 (Proteasome subunit L)

35 -3.9 0003756 protein disulfide 0006886 intracellular protein Endoplasmic reticulum protein ERp29 0005783 endoplasmic reticulum P30040 14 3 ±0.5 isomerase activity transport precursor (ERp31) (ERp28) 5 (2) 0006457 protein folding

Peroxiredoxin-5, mitochondrial precursor (EC 1.11.1.15) (Prx-V) (Peroxisomal antioxidant enzyme) 22 11 0006954 inflammatory response 0005739 mitochondrion 0004601 peroxidase activity P30044 (PLP) (Thioredoxin reductase) 21 2 DC 1 0006979 response to oxidative 0005777 peroxisome (Thioredoxin peroxidase PMP20) 3 1 stress (Antioxidant enzyme B166) (AOEB166) (TPx type VI) (Liver tissue 2D-page spo Phosphatidylethanolamine-binding protein 1 (PEBP-1) (Prostatic-binding 35 0008429 protein) (HCNPpp) (Neuropolypeptide P30086 18 2 DC phosphatidylethanolamine binding h3) (Raf kinase inhibitor protein) (RKIP) 6 [Contains: Hippocampal cholinergic neurostimulating peptide (HCNP)] 0048306 calcium-dependent 0008285 negative regulation of Protein S100-A11 (S100 calcium- 13 0005737 cytoplasm protein binding cell proliferation P31949 binding protein A11) (Protein S100C) 15 1 DC 0005634 nucleus 0042803 protein 0008156 negative regulation of (Calgizzarin) (MLN 70) 1 0001726 ruffle homodimerization activity DNA replication 0048154 S100 beta binding 0007165 signal transduction

Replication protein A 14 kDa subunit 20 -1.2 20 0005662 DNA replication factor A 0003697 single-stranded DNA 0006260 DNA replication P35244 (RP-A) (RF-A) (Replication factor-A 14 1 - 1 complex binding

protein 3) (p14) 5 (1) 1

Vacuolar ATP synthase subunit E (EC 16 -2.3 0016469 proton-transporting two- 3.6.3.14) (V-ATPase E subunit) 0005515 protein binding 0015992 proton transport P36543 6 1 - sector ATPase complex (Vacuolar proton pump E subunit) (V- 3 (1) ATPase 31 kDa subunit) (P31)

15 0005794 Golgi apparatus 0008047 enzyme activator activity P40616 ADP-ribosylation factor-like protein 1 12 1 DC 0003924 GTPase activity 3 ATP synthase O subunit, mitochondrial 14 0005753 proton-transporting ATP 0005215 transporter activity

P48047 precursor (EC 3.6.3.14) (Oligomycin 6 1 PC synthase complex (s NAS:ProtInc

sensitivity conferral protein) (OSCP) 1

Phosphatidylinositol transfer protein 14 0006629 lipid metabolism

P48739 beta isoform (PtdIns transfer protein 7 1 DC NAS:ProtInc

beta) (PtdInsTP) (PI-TP-beta) 1

26S proteasome non-ATPase regulatory subunit 7 (26S proteasome 85 -2.8 0005838 proteasome regulatory regulatory subunit rpn8) (26S P51665 28 6 - particle (sensu Eukar proteasome regulatory subunit S12) 12 (1) (Proteasome subunit p40) (Mov34 protein homolog)

Spermine synthase (EC 2.5.1.22) 16 0004766 spermidine synthase 0006555 methionine metabolism P52788 (Spermidine aminopropyltransferase) 5 1 PC activity 0006595 polyamine metabolism (SPMSY) 1

Methylosome subunit pICln (Chloride conductance regulatory protein ICln) 12 (I(Cln)) (Chloride channel, nucleotide 0005886 plasma membrane 0008015 circulation P54105 10 1 PC sensitive 1A) (Chloride ion current 0006810 transport 1 inducer protein) (ClCI) (Reticulocyte pICln)

IgG receptor FcRn large subunit p51 27 precursor (FcRn) (Neonatal Fc 0004872 receptor activity 0006955 immune response P55899 15 2 PC receptor) (IgG Fc fragment receptor 0007565 pregnancy 2 transporter, alpha chain)

NEDD8-conjugating enzyme Ubc12 (EC 33 6.3.2.-) (Ubiquitin-conjugating enzyme 0005515 protein binding P61081 19 3 DC E2 M) (NEDD8 protein ligase) (NEDD8 5 carrier protein)

Proteasome activator complex subunit 3 (Proteasome activator 28-gamma subunit) (PA28gamma) (PA28g) 28 0042802 identical protein binding P61289 (Activator of multicatalytic protease 11 2 PC

subunit 3) (11S regulator complex 5 subunit gamma) (REG-gamma) (Ki nuclear autoantigen)

18 Lysozyme C precursor (EC 3.2.1.17) P61626 8 1 DC (1,4-beta-N-acetylmuramidase C) 2

43 1.0 33 Small nuclear ribonucleoprotein Sm D2 0005515 protein binding P62316 33 4 ±0.1 2 (snRNP core protein D2) (Sm-D2) 9 (3) 2 16 -1.3 Small nuclear ribonucleoprotein Sm D3 0005515 protein binding P62318 7 1 - (snRNP core protein D3) (Sm-D3) 5 (1)

15

P63173 60S ribosomal protein L38 17 1 PC

2

0019899 enzyme binding Ubiquitin-conjugating enzyme E2 L3 78 1.6 0004840 ubiquitin conjugating 0006464 protein modification (EC 6.3.2.19) (Ubiquitin-protein ligase 0000151 ubiquitin ligase complex P68036 63 6 ±0.7 enzyme activity 0006511 ubiquitin-dependent L3) (Ubiquitin carrier protein L3) 11 (3) 0004842 ubiquitin-protein ligase protein catabolism (UbcH7) (E2-F1) (L-UBC) activity Platelet-activating factor acetylhydrolase IB subunit beta (EC 17 1.5 0003847 1-alkyl-2- 3.1.1.47) (PAF acetylhydrolase 30 kDa P68402 8 1 - acetylglycerophosphocholine ester subunit) (PAF-AH 30 kDa subunit) 4 (1) (PAF-AH subunit beta) (PAFAH subunit beta)

12 Splicing factor, arginine/serine-rich 3 0005515 protein binding P84103 12 1 PC (Pre-mRNA-splicing factor SRP20) 0003723 RNA binding 2

14 Putative RNA-binding protein 3 (RNA- 0003723 RNA binding 0006396 RNA processing P98179 11 1 PC binding motif protein 3) (RNPL) 2

0051382 kinetochore assembly 0007079 mitotic chromosome 0043515 kinetochore binding 22 0000775 chromosome, pericentric movement towards spindle 0003777 microtubule motor Q02224 Centromeric protein E (CENP-E) 1 2 PC region 0000089 mitotic metaphase activity 2 0005634 nucleus 0007080 mitotic metaphase plate 0005515 protein binding congression

Proteasome activator complex subunit 1 (Proteasome activator 28-alpha subunit) (PA28alpha) (PA28a) (Activator of 85 1.8 0005737 cytoplasm Q06323 multicatalytic protease subunit 1) (11S 28 6 ±0.5 0000502 proteasome complex regulator complex subunit alpha) (REG- 26 (5) alpha) (Interferon gamma up-regulated I-51 Bile salt sulfotransferase (EC 2.8.2.14) (Hydroxysteroid Sulfotransferase) 30 0008146 sulfotransferase activity 0007586 digestion NAS:ProtInc Q06520 (HST) (Dehydroepiandrosterone 8 2 DC 0008202 steroid metabolism sulfotransferase) (DHEA-ST) (ST2) 4 (ST2A3) 0008637 apoptotic mitochondrial changes 27 1.2 0007281 germ cell development Apoptosis regulator BAX, cytoplasmic 0005515 protein binding Q07814 11 2 - 0008624 induction of apoptosis by isoform beta 6 (1) extracellular sig 0008634 negative regulation of survival gene produc

Quinone oxidoreductase (EC 1.6.5.5) 13 -2.9 0007601 visual perception Q08257 (NADPH:quinone reductase) (Zeta- 8 1 -

crystallin) 3 (1)

65 -9.3

Q0VGC2 EIF1AX protein 36 4 -

16 (1)

0008017 microtubule binding 15 0007067 mitosis 0005634 nucleus 0005515 protein binding Q13148 TAR DNA-binding protein 43 (TDP-43) 5 1 PC 0006366 transcription from RNA 0003700 transcription factor 1 polymerase II promoter activity

62 2.2 Multisynthetase complex auxiliary Q13155 28 4 - component p38 (Protein JTV-1) 7 (1)

Chromobox protein homolog 3 20 13 (Heterochromatin protein 1 homolog 0005634 nucleus 0003682 chromatin binding Q13185 7 2 PC 1 gamma) (HP1 gamma) (Modifier 2 0005515 protein binding 2 1 protein) (HECH)

0004003 ATP-dependent DNA Ras-GTPase-activating protein-binding 13 helicase activity 0007265 Ras protein signal protein 1 (EC 3.6.1.-) (ATP-dependent 0005634 nucleus Q13283 3 1 PC 0004004 ATP-dependent RNA transduction DNA helicase VIII) (GAP SH3-domain- 4 helicase activity binding protein 1) (G3BP-1) (HDH-VIII) 0005515 protein binding 0051092 activation of NF-kappaB transcription factor IMP:HGNC Ubiquitin-conjugating enzyme E2 0005515 protein binding 0005737 cytoplasm 0030154 cell differentiation variant 1 (UEV-1) (CROC-1) (Ubiquitin- 21 -1.9 13 10 0016563 transcriptional activator 0005634 nucleus 0043123 positive regulation of I- Q13404 conjugating enzyme variant Kua) 8 2 - 1 1 activity 0031371 ubiquitin conjugating kappaB kinase/NF-k IMP:HGNC (TRAF6-regulated IKK activator 1 beta 4 (1) 1 1 0004840 ubiquitin conjugating enzyme complex 0000209 protein polyubiquitination Uev1A) enzyme activity 0006282

28 kDa heat- and acid-stable 44 11 phosphoprotein (PDGF-associated 0008283 cell proliferation Q13442 21 3 PC 1 protein) (PAP) (PDGFA-associated 0007165 signal transduction 9 1 protein 1) (PAP1)

18 1.5 0016021 integral to membrane Q13774 NCA protein precursor 6 1 -

5 (1) 0051297 centrosome organization and biogenesis IMP:HGNC 0030951 establishment and/or maintenance of microtu Cytoskeleton-associated protein 5 13 IMP:HGNC 0005813 centrosome 0005515 protein binding Q14008 (Colonic and hepatic tumor over- 0 1 DC 0050658 RNA transport

expressed protein) (Ch-TOG protein) 1 ISS:HGNC 0051300 spindle pole body organization and biogenesis IMP:HGNC

Eukaryotic translation initiation factor 30 0016281 eukaryotic translation 0003723 RNA binding 0006446 regulation of translational 4H (eIF-4H) (Williams-Beuren Q15056 21 2 PC initiation factor 4F 0003743 translation initiation initiation syndrome chromosome region 1 2 factor activity protein)

13

Q15394 KIAA0005 protein (Fragment) 2 1 PC

1

68 -2.1 0005634 nucleus 0003677 DNA binding 0006310 DNA recombination Q15631 Translin 23 5 -

12 (1)

17 -2.1 Q1WDE Cell-cycle related and expression- 4 1 - 7 elevated protein in tumor 2 (1)

32 1.9 0030833 regulation of actin 0005856 cytoskeleton Q2LE71 Actin related protein 2/3 complex 13 2 ±0.1 filament polymerization

13 (2)

15 0006355 regulation of Calcium regulated heat stable protein 1, 0003677 DNA binding Q2YDX5 10 1 DC transcription, DNA-dependent 24kDa 2

29 1.2 0005524 ATP binding 0006468 protein amino acid Protein kinase, cAMP-dependent, Q32P54 10 2 - 0004674 protein serine/threonine phosphorylation catalytic, alpha 4 (1) kinase activity

62 5.8 15 0004452 isopentenyl-diphosphate 0008299 isoprenoid biosynthesis Q32Q13 IDI1 protein (Fragment) 25 4 ±2.7 1 delta-isomerase act

14 (3) 1

24 -1.5 0016020 membrane Q3KQZ2 SYNGR2 protein 7 2 ±0.3

7 (2) 15 -2.5 13 0005488 binding Q3ZCU9 STIP1 protein 2 1 - 1

2 (1) 1

23 -4.3

Q4AEJ6 KIAA0487 protein (Fragment) 10 2 -

4 (1)

15

Q4KMQ1 C9orf75 protein (Fragment) 4 1 PC

1

15 0008440 inositol trisphosphate 3- Inositol hexaphosphate kinase 3 variant Q53ER7 5 1 DC kinase activity (Fragment) 2 0016301 kinase activity

35 -3.9 0003735 structural constituent of Ribosomal protein S5 variant 0005622 intracellular 0006412 protein biosynthesis Q53G25 13 2 ±0.1 ribosome (Fragment) 0015935 small ribosomal subunit 29 (2)

0005524 ATP binding 0005737 cytoplasm 0016787 hydrolase activity 56 13 0005829 cytosol Proteasome 26S ATPase subunit 1 0017111 nucleoside- 0030163 protein catabolism Q53HB3 15 4 PC 1 0005634 nucleus variant (Fragment) triphosphatase activity 7 1 0043234 protein complex 0000166 nucleotide binding

49 3.0 0016855 racemase and 0008152 metabolism Q53QS9 Hypothetical protein COP9 30 4 - epimerase activity, acting on

9 (1)

55 1.5 0005198 structural molecule VAMP (Vesicle-associated membrane Q53XM7 22 4 ±0.6 activity protein)-associated protein B and C 16 (3)

19 14 0006886 intracellular protein 0030125 clathrin vesicle coat Q53XZ1 Clathrin, light polypeptide (Lca) 13 1 PC 1 transport

2 1

0005524 ATP binding 25 19 17 0016469 proton-transporting two- 0046933 hydrogen-transporting 0015986 ATP synthesis coupled ATPase, H+ transporting, lysosomal Q53YD9 8 2 DC 1 1 sector ATPase complex ATP synthase activity proton transport 70kDa, V1 subunit A, isoform 1 2 1 1 0046961 hydrogen-transporting ATPase activity, rota 33

Q549M8 CLE7 (Lcrp369) 14 2 PC

4