Fascia Iliaca Compartment Block: Landmark Approach Guidelines for Use in the Emergency Department
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Softgels' Clear Advantages
DEEPDIVE REPORT March 2019 naturalproductsinsider.com Softgels’ Clear Advantages Report brought to you by DEEPDIVE REPORT Softgels’ Clear Advantages Contents Market snapshot ..................................................................................... 3 Consumer appeal .................................................................................... 4 Softgel history .......................................................................................... 6 Advantages of softgels ........................................................................... 7 How softgels are made .......................................................................... 9 Softgel challenges and solutions .......................................................11 Oxidation ...........................................................................................11 Consumer experience .......................................................................12 Dietary considerations ......................................................................12 Shelf stability ....................................................................................14 Bioavailability ....................................................................................14 Innovative developments .....................................................................16 Copyright © 2019 Informa Exhibitions LLC. All rights reserved. The publisher reserves the right to accept or reject any advertising or editorial material. Advertisers, and/or their agents, assume the -
Oral Drug Delivery: Formulation Selection Methods & Novel Delivery Technologies
ORAL DRUG DELIVERY: FORMULATION SELECTION METHODS & NOVEL DELIVERY TECHNOLOGIES OUTSTANDING ISSUE SPONSOR www.ondrugdelivery.com “Oral Drug Delivery: Formulation Selection Approaches CONTENTS & Novel Delivery Technologies” This edition is one in the ONdrugDelivery series of pub- No Longer a Hit-or-Miss Proposition: lications from Frederick Furness Publishing. Each issue focuses on a specific topic within the field of drug deliv- Once-Daily Formulation for Drugs with ery, and is supported by industry leaders in that field. pH-Dependent Solubility Gopi Venkatesh, Director of R&D & Anthony Recupero, EDITORIAL CALENDAR 2011: Senior Director, Business Development June: Injectable Drug Delivery (Devices Focus) Aptalis Pharmaceutical Technologies 4-8 July: Injectable Drug Delivery (Formulations Focus) September: Prefilled Syringes A possible approach for the desire to innovate October: Oral Drug Delivery Brian Wang, CEO & Dr Junsang Park, CSO November: Pulmonary & Nasal Drug Delivery (OINDP) GL PharmTech 10-13 December: Delivering Biotherapeutics SUBSCRIPTIONS: COMPANY PROFILE - To arrange your FREE subscription (pdf or print) to Mayne Pharma International 14-15 ONdrugDelivery, contact: Guy Furness, Publisher From Powder to Pill: A Rational Approach to T: +44 (0) 1273 78 24 24 E: [email protected] Formulating for First-into-Man Studies Dr Robert Harris, Director, Early Development SPONSORSHIP/ADVERTISING: Molecular Profiles Ltd 16-19 To feature your company in ONdrugDelivery, contact: Guy Furness, Publisher LiquiTime* Oral Liquid -
Oral Dosage Forms That Should Not Be Crushed Formulary-Specific List for VCMC and SPH
Oral Dosage Forms That Should Not be Crushed Formulary-Specific List for VCMC and SPH Generic Brand Dosage Form(s) Reasons/Comments amoxicillin-clavulanate Augmentin XR Tablet Slow-release (b,h) aspirin Aspirin EC Caplet; Tablet Slow-release; Enteric-coated aspirin and dipyridamole Aggrenox XR Capsule Slow-release atazanavir Reyataz Capsule Note: an oral powder is available, see prescribing information for administration instructions atomoxetine Strattera Capsule Note: capsule contents can cause ocular irritation - Do not open capsules as contents are an ocular irritant benzonatate Tessalon Perles Capsule Note: swallow whole; local anesthesia of the oral mucosa; choking could occur - Capsules are liquid-filled “perles” - Do not alter (break, cut, chew) integrity of dosage form; local mucosal irritant and anesthetic bisacodyl Dulcolax Capsule; Tablet Enteric-coated (c) bosentan Tracleer Tablet Note: women who are, or may become, pregnant, should not handle crushed or broken tablets brivaracetam Briviact Tablet Film-coated (b) budesonide Entocort EC Capsule Enteric-coated (a) - Capsules contain enteric-coated granules in extended-release matrix; can open capsules but do not crush contents - Products are formulated to release active drug at mid- to late small intestine buPROPion Wellbutrin XL Tablet Slow-release - Do not crush extended-release tablets - Immediate-release tablet products may be film-coated March 2019 carvedilol phosphate Coreg CR Capsule Slow-release (a) (Note: may add contents of capsule to chilled, not warm, applesauce -
Study Protocol and Statistical Analysis Plan
The University of Texas Southwestern Medical Center at Dallas Institutional Review Board PROJECT SUMMARY Study Title: Ultrasound-guided fascia iliaca compartment block versus periarticular infiltration for pain management after total hip arthroplasty: a randomized controlled trial Principal Investigator: Irina Gasanova, MD Sponsor/Funding Source: Department of Anesthesiology and Pain Management, UT Southwestern Medical School IRB Number: STU 122015-022 NCT Number: NCT02658240 Date of Document: 01 April 2016 Page 1 of 7 Purpose: In this randomized, controlled, observer-blinded study we plan to evaluate ultrasound-guided fascia iliaca compartment block with ropivacaine and periarticular infiltration with ropivacaine for postoperative pain management after total hip arthroplasty (THA). Background: Despite substantial advances in our understanding of the pathophysiology of pain and availability of newer analgesic techniques, postoperative pain is not always effectively treated (1). Optimal pain management technique balances pain relief with concerns about safety and adverse effects associated with analgesic techniques. Currently, postoperative pain is commonly treated with systemic opioids, which are associated with numerous adverse effects including nausea and vomiting, dizziness, drowsiness, pruritus, urinary retention, and respiratory depression (2). Use of regional and local anesthesia has been shown to reduce opioid requirements and opioid-related side effects. Therefore, their use has been emphasized (3, 4, 5, 6). Fascia Iliaca compartment block (FICB) is a field block that blocks the nerves from the lumbar plexus supplying the thigh (i.e., lateral femoral cutaneous femoral and obturator nerves). The obturator nerve is sometimes involved in the FICB but probably plays little role in postoperative pain relief for most surgeries of the hip and proximal femur. -
A Randomized and Observer Blinded Comparison of Continuous Femoral
a & hesi C st lin e ic n a l A f R Möller. J Anesthe Clinic Res 2011, 4:1 o e l s e a Journal of Anesthesia & Clinical DOI: 10.4172/2155-6148.1000.277 a n r r c u h o J ISSN: 2155-6148 Research Case Report Open Access A Randomized and Observer Blinded Comparison of Continuous Femoral Block and Fascia Iliaca Compartment Block in Hip Replacement Surgery Thorsten Möller1,2, Sabine Benthaus2, Maria Huber2, Ingrid Bentrup2, Markus Schofer3, Leopold Eberhart2, Hinnerk Wulf2 and Astrid Morin2* 1Department of Anesthesiology and Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany 2Department of Anesthesiology and Critical Care Medicine, Philipps-University Marburg, Marburg, Germany 3Department of Orthopedy and Rheumatology, Philipps-University Marburg, Marburg, Germany Abstract Background: Techniques, analgesic effects and functional outcome of continuous femoral nerve and fascia iliaca compartment blocks were compared in patients undergoing hip replacement surgery. Methods: 80 patients were enroled in this randomized and observer-blinded study. 40 patients received a femoral nerve catheter with a stimulating catheter (FEM group) and 40 patients a fascia iliaca compartment catheter (FIC group). Before surgery, the catheters were placed. 50 mL prilocaine 1% was administered and a continuous infusion of ropivacaine 0.2% was maintained for 24 hours. Postoperative pain management with non-steroidal anti- inflammatory agents was standardized during the first 24 hours. No bolus application of a local anesthetic was allowed during this period. Intravenous opioide PCA with piritramide (comparable with morphin) was provided for 24 hours, and the patients were instructed to titrate their pain below a level of visual analogue scale of 3. -
Continuous Pericapsular Nerve Group Block for Postoperative Pain
Fujino et al. JA Clinical Reports (2021) 7:22 https://doi.org/10.1186/s40981-021-00423-1 CASE REPORT Open Access Continuous pericapsular nerve group block for postoperative pain management in total hip arthroplasty: report of two cases Takashi Fujino1* , Masahiko Odo1, Hisako Okada1, Shinji Takahashi2 and Toshihiro Kikuchi1 Abstract Background: Total hip arthroplasty (THA) is one of the surgical procedures associated with severe postoperative pain. Appropriate postoperative pain management is effective for promoting early ambulation and reducing the length of hospital stay. Effects of conventional pain management strategies, such as femoral nerve block and fascia iliaca block, are inadequate in some cases. Case presentation: THA was planned for 2 patients with osteoarthritis. In addition to general anesthesia, continuous pericapsular nerve group (PENG) block and lateral femoral cutaneous nerve (LFCN) block were performed for postoperative pain management. Numerical rating scale (NRS) scores measured at rest and upon movement were low at 2, 12, 24, and 48 h postoperatively, suggesting that the treatments were effective for managing postoperative pain. The Bromage score at postoperative days (POD) 1 and 2 was 0. Conclusion: Continuous PENG block and LFCN block were effective for postoperative pain management in patients who underwent THA. PENG block did not cause postoperative motor blockade. Keywords: Pericapsular nerve group (PENG) block, Continuous peripheral nerve block, Total hip arthroplasty, Peripheral nerve block Background reported that it was more effective for managing postop- Total hip arthroplasty (THA) is associated with signifi- erative pain associated with THA than conventional cant postoperative pain [1]. Opioids are typically used peripheral nerve blocks [6]. -
Ultrasound-Guided Fascia Iliaca Compartment Block (FICB)
Ultrasound-Guided Fascia Iliaca Compartment Block (FICB) Hip Fracture Any of the following present? 1) Neurologic deficit 2) Multisystem Trauma 3) Allergy to local anesthetic Yes *Anticoagulated patients – physician No discretion Standard Care Procedure Details 1) Document distal neurovascular exam in EPIC 1) PO acetaminophen 2) Consult ortho (do not need to await callback) (1,000mg) 3) Obtain verbal consent from patient 2) Consider 0.1 mg/kg 4) Position Patient and U/S Machine morphine or opioid 5) Order Bupivacaine (dose dependent) a. Max 2 mg/kg equivalent b. i.e. 100 mg safe for 50 kg patient 3) Screening labs, CXR, 6) Standard ASA monitoring (telemetry during procedure with ECG, type and screen continuous pulse oximetry, BP measurement, and IV access) 7) Perform FICB 4) Consult orthopedics and medicine as 8) Inform patients on block characteristics: a. Onset ~ 20 minutes necessary b. Duration ~ 8-12 hours Equipment Required Counseling Ultrasound Machine 1) Linear/Vascular Probe set to “Nerve” Benefits setting for best results Decreases: Anesthetic: 1) Pain 1) 0.5% Bupivacaine (20-30 cc) 2) 1% Lidocaine (3-5 cc) 2) Delirium 3) Opioids Saline (10 cc) 4) Hypoxia Syringes: 1) 30 cc 2) 3-5 cc Risks Needles: 1) Pain at injection site 1) Blunt fill 2) Temporary nerve palsy 2) 25G 3) 18G LP needle 3) Intravascular injection Chloroprep or Alcohol swab(s) 4) Local Anesthetic Systemic Toxicity * (LAST) * LAST (local anesthetic systemic toxicity) 1) Rare and only with intravascular injection which an ultrasound guided approach prevents. 2) Signs include arrhythmias, seizures, convulsions 3) Treatment a. -
Herestraat 49, B-3000 Leuven Yves Kremer, CU Saint-Luc, Av
Editor | Prof. Dr. V. Bonhomme CO-Editors | Dr. Y. Kremer — Prof. Dr. M. Van de Velde ACTA ANAESTHESIOLOGICA JOURNAL OF THE BELGIAN SOCIETY OF ANESTHESIOLOGY, RESUSCITATION, PERIOPERATIVE MEDICINE AND PAIN MANAGEMENT (BeSARPP) BELGICA Indexed in EMBASE l EXCERPTA MEDICA ISSN: 2736-5239 Suppl. 1 202071 Master Theses www.besarpp.be Cover-1 -71/suppl.indd 1 12/01/2021 12:37 ACTA ANÆSTHESIOLOGICA BELGICA 2020 – 71 – Supplement 1 EDITORS Editor-in-chief : Vincent Bonhomme, CHU Liège, av. de l’Hôpital 1, B-4000 Liège Co-Editors : Marc Van de Velde, KU Leuven, Herestraat 49, B-3000 Leuven Yves Kremer, CU Saint-Luc, av. Hippocrate, B-1200 Woluwe-Saint-Lambert Associate Editors : Margaretha Breebaart, UZA, Wilrijkstraat 10, B-2650 Edegem Christian Verborgh, UZ Brussel, Laarbeeklaan 101, B-1090 Jette Fernande Lois, CHU Liège, av. de l’Hôpital 1, B-4000 Liège Annelies Moerman, UZ Gent, C. Heymanslaan 10, B-9000 Gent Mona Monemi, CU Saint-Luc, av. Hippocrate, B-1200 Woluwe-Saint-Lambert Steffen Rex, KU Leuven, Herestraat 49, B-3000 Leuven Editorial assistant Carine Vauchel Dpt of Anesthesia & ICM, CHU Liège, B-4000 Liège Phone: 32-4 321 6470; Email: [email protected] Administration secretaries MediCongress Charlotte Schaek and Astrid Dedrie Noorwegenstraat 49, B-9940 Evergem Phone : +32 9 218 85 85 ; Email : [email protected] Subscription The annual subscription includes 4 issues and supplements (if any). 4 issues 1 issue (+supplements) Belgium 40€ 110€ Other Countries 50€ 150€ BeSARPP account number : BE97 0018 1614 5649 - Swift GEBABEBB Publicity : Luc Foubert, treasurer, OLV Ziekenhuis Aalst, Moorselbaan 164, B-9300 Aalst, phone: +32 53 72 44 61 ; Email : [email protected] Responsible Editor : Prof. -
Capsule Robot: a Theranostic Approach
Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Volume 3 Issue 10 October 2019 Review Article Capsule Robot: A Theranostic Approach Pradnya Palekar Shanbhag*, Tejal Gawade, Prerna Patil and Priyanka Deshmukh Department of Pharmaceutics, Oriental College of Pharmacy, Sanpada, Navi Mumbai, Affiliated to University of Mumbai, India *Corresponding Author: Pradnya Palekar Shanbhag, Head and Professor, Department of Pharmaceutics, Oriental College of Pharmacy, Sanpada,Received: Navi September Mumbai, 11, Affiliated 2019 ; Published: to University September of Mumbai, 27, India. 2019 DOI: 10.31080/ASPS.2019.03.0407 Abstract Increasing development in healthcare systems and availability of efficient miniaturized components or systems that are economic has led to profound scope for research in many new fields. Capsule robot was one such fictional idea that turned into factual reality because of use of applicative miniaturized components. Initially capsule robots were developed for endoscopic applications. These travel inside the gastrointestinal tract and thus capture images of the gastrointestinal tract and related areas. Later, capsule robots were developed to be used as the unique tool to construct micron and sub-micron sized drug delivery systems for target delivery and treatment. This article highlights on various aspects of capsule robots in diagnosis and therapy of various disorders and diseases, togetherKeywords: called Capsule theranostic Robot; approachEndoscopy; in Diagnosis;drug delivery Therapy systems. Introduction The rising demand for non invasive methodology for diagnosis controlled manner, Drug Delivery System (DDS) capsule endoscopy was designed. There are quite a number of research studies using rine type capsules which travel inside the body were used for en Microelectromechanical Systems (MEMS) for evaluating the drug and treatment led to the invention of capsule robots. -
Static Stretching Time Required to Reduce Iliacus Muscle Stiffness
Sports Biomechanics ISSN: 1476-3141 (Print) 1752-6116 (Online) Journal homepage: https://www.tandfonline.com/loi/rspb20 Static stretching time required to reduce iliacus muscle stiffness Shusuke Nojiri, Masahide Yagi, Yu Mizukami & Noriaki Ichihashi To cite this article: Shusuke Nojiri, Masahide Yagi, Yu Mizukami & Noriaki Ichihashi (2019): Static stretching time required to reduce iliacus muscle stiffness, Sports Biomechanics, DOI: 10.1080/14763141.2019.1620321 To link to this article: https://doi.org/10.1080/14763141.2019.1620321 Published online: 24 Jun 2019. Submit your article to this journal Article views: 29 View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=rspb20 SPORTS BIOMECHANICS https://doi.org/10.1080/14763141.2019.1620321 Static stretching time required to reduce iliacus muscle stiffness Shusuke Nojiri , Masahide Yagi, Yu Mizukami and Noriaki Ichihashi Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan ABSTRACT ARTICLE HISTORY Static stretching (SS) is an effective intervention to reduce muscle Received 25 September 2018 stiffness and is also performed for the iliopsoas muscle. The iliop- Accepted 9 May 2019 soas muscle consists of the iliacus and psoas major muscles, KEYWORDS among which the former has a greater physiological cross- Iliacus muscle; static sectional area and hip flexion moment arm. Static stretching stretching; ultrasonic shear time required to reduce muscle stiffness can differ among muscles, wave elastography and the required time for the iliacus muscle remains unclear. The purpose of this study was to investigate the time required to reduce iliacus muscle stiffness. Twenty-six healthy men partici- pated in this study. -
Illuminating the Iliacus
THE GENTLE LIFESTYLE developingcore strength practicaltips for a happylife i Ff f- i JO-IL--rra-,*= i f,I"RtshingHow to avoid injury o Vnel T \.'E. I LOrnwi A littlecove of paradise l[luminatingthe o IACUSBy Liz Koch Some muscles just seem to grab our attention and dominate our awareness while stretching: anterior superior ,1" quads, hamstrings and abdominals are all too iliacspine I ,_\l - ____=_ | familiar. But ask anyone where their iliacus anterior ---\- muscle is and the response most often will be inferior iliacspine one of uncertainty. And yet the iliacus directly influences range of motion within the hip sockets rectus femoris and maintains pelvic integrity so essential to tendon flexibility and strength. gluteusminimus Liningthe internalpelvic girdle the iliacusopens like a muscle, fan, creatinga healthybowl-like structure for all and attachment site on greater abdominalorgans and viscera.lt is the well-functioning trochanter iliacusthat maintainsfull-centered sockets for the femur ball and helpsstabilise the sacraliliac joints by counter- balancingthe largeand powerfulgluteus maximus muscles(buttock muscles). site ol attachment of fibrocartilagenous posterior The lliacusis a abdominalwall muscle pubic symphysis originatingfrom the superiorpart of the iliacfossa (the insideof your hip).lt is innervatedby the femoralnerve in ischiumand inferior the abdomen(at lumbar2 and 3) and its' fibrespass ischial tuberosity pubic inferiorlyand mediallybeneath the inguinalligament. ramus Sharinga tendon at the lessertrocanter of the femur (i.e. pubofemoral ligament the innerleg), with the psoas muscle,the iliacusis part of the core ilio-psoasmuscle group. Togetherthe psoasand iliacusform a full stablepelvic bowl and centeredhip jointsfor maximumrotation and Recentlytwo women who attendedan llio-psoasretreat freedomof leg movement.Health or diseasein one will returnedhome and immediatelyconceived. -
Anatomical Study on the Psoas Minor Muscle in Human Fetuses
Int. J. Morphol., 30(1):136-139, 2012. Anatomical Study on the Psoas Minor Muscle in Human Fetuses Estudio Anatómico del Músculo Psoas Menor en Fetos Humanos *Danilo Ribeiro Guerra; **Francisco Prado Reis; ***Afrânio de Andrade Bastos; ****Ciro José Brito; *****Roberto Jerônimo dos Santos Silva & *,**José Aderval Aragão GUERRA, D. R.; REIS, F. P.; BASTOS, A. A.; BRITO, C. J.; SILVA, R. J. S. & ARAGÃO, J. A. Anatomical study on the psoas minor muscle in human fetuses. Int. J. Morphol., 30(1):136-139, 2012. SUMMARY: The anatomy of the psoas minor muscle in human beings has frequently been correlated with ethnic and racial characteristics. The present study had the aim of investigating the anatomy of the psoas minor, by observing its occurrence, distal insertion points, relationship with the psoas major muscle and the relationship between its tendon and muscle portions. Twenty-two human fetuses were used (eleven of each gender), fixed in 10% formol solution that had been perfused through the umbilical artery. The psoas minor muscle was found in eight male fetuses: seven bilaterally and one unilaterally, in the right hemicorpus. Five female fetuses presented the psoas minor muscle: three bilaterally and two unilaterally, one in the right and one in the left hemicorpus. The muscle was independent, inconstant, with unilateral or bilateral presence, with distal insertions at different anatomical points, and its tendon portion was always longer than the belly of the muscle. KEY WORDS: Psoas Muscles; Muscle, Skeletal; Anatomy; Gender Identity. INTRODUCTION When the psoas minor muscle is present in humans, The aim of the present study was to investigate the it is located in the posterior wall of the abdomen, laterally to anatomy of the psoas minor muscle in human fetuses: the lumbar spine and in close contact and anteriorly to the establishing the frequency of its occurrence according to sex; belly of the psoas major muscle (Van Dyke et al., 1987; ascertaining the distal insertion points; analyzing the possible Domingo, Aguilar et al., 2004; Leão et al., 2007).