l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405 OMB No 1545-0052 Form 990-PF Return of Private Foundation or Section 4947(a)(1) Trust Treated as Private Foundation Department of the Treasury 2014 0- Do not enter social security numbers on this form as it may be made public. Internal Revenue Service 0- Information about Form 990-PF and its instructions is at www.irs.gov/form990pf .

For calendar year 2014, or tax year beginning 01 - 01-2014 , and ending 12-31-2014

Name of foundation A Employer identification number THE SIMONS FOUNDATION INC 13-3794889 O/o FANG HAN Number and street (or P 0 box number if mail is not delivered to street address) Room/suite U ieiepnone number (see instructions) 160 FIFTH AVENUE 7TH FLOOR (646) 654-0066

City or town, state or province, country, and ZIP or foreign postal code C If exemption application is pending, check here F NEW YORK, NY 10010

G Check all that apply r'Initial return r'Initial return of a former public charity D 1. Foreign organizations, check here F

r Final return r'Amended return 2. Foreign organizations meeting the 850/, r- Address change r'Name change test, check here and attach computation F E If private foundation status was terminated H C heck type of organization Section 501(c)(3) exempt private foundation und er section 507 ( b )( 1 )( A ), c hec k here F_ Section 4947(a)(1) nonexempt charitable trust r'Other taxable private foundation I Fair market value of all assets at end J Accounting method F Cash F Accrual F If the foundation is in a 60-month termination of year (from Part II, col. (c), r Other (specify) under section 507(b)(1)(B), check here 0- F line 2,358,866,359 (Part I, column (d) must be on cash basis.)

(d) Disbursements Analysis of Revenue and Expenses (The (a) Revenue and (b) Net investment (c) Adjusted net for charitable total of amounts in columns (b), (c), and (d) may not expenses per income income purposes necessanly equal the amounts in column (a) (see books instructions) ) (cash basis only) 1 Contributions, gifts, grants, etc , received (attach

schedule) ...... 23,137,304

2 Check Nil F- if the foundation is not required to attach Sch B ...... 3 Interest on savings and temporary cash investments 26,885 26,855 4 Dividends and interest from securities. . .

5a Gross rents ...... 1,368,688 1,368,688 b Net rental income or (loss) 133,441 CO 6a Net gain or (loss) from sale of assets not on line 10 198,971,483 7V b Gross sales price for all assets on line 6a 472, 555, 268 7 Capital gain net income (from Part IV, line 2) . 225,186,543 8 Net short-term capital gain ...... 9 Income modifications ......

10a Gross sales less returns and allowances b Less Cost of goods sold . c Gross profit or (loss) (attach schedule) . . 11 Other income (attach schedule) . . . . 12,767,965

12 Total . Add lines 1 through 11 . . . . . 223,504,360 239,350,051 13 Compensation of officers, directors, trustees, etc 997,654 997,654

14 Other employee salaries and wages . . . 11,663,983 10,776,802

15 Pension plans, employee benefits . . . . 3,581,963 3,459,017 16a Legal fees (attach schedule) ...... 95 207,818 0 0 219,693 b Accounting fees (attach schedule) ...... 152,550 0 0 126,750 W c Other professional fees (attach schedule) . . . . 95 364,486 366,067 17 Interest ...... 11,252 11,252

18 Taxes (attach schedule) (see instructions) . . . 2, 869,535 1V 19 Depreciation (attach schedule) and depletion . . . 2,500,253

20 Occupancy ...... 3,551,105 3,652,602 21 Travel, conferences, and meetings . . . . 4,203,605 4,281,503 22 Printing and publications ...... 263,597 213,597 23 Other expenses (attach schedule) ...... 12,616,211 10,475,238 11,526,842 5= ^, 24 Total operating and administrative expenses. Add lines 13 through 23 ...... 42,984,012 10,475,238 0 35,631,779

25 Contributions, gifts, grants paid . . . . . 272,677,777 232,372,215

26 Total expenses and disbursements . Add lines 24 and 25 315,661,789 10,475,238 0 268,003,994 27 Subtract line 26 from line 12 a Excess of revenue over expenses and disbursements -92,157,429 b Net investment income (if negative, enter -0-) 228,874,813 c Adjusted net income (if negative, enter -0-) . For Paperwork Reduction Act Notice, see instructions . Cat No 11289X Form 990-PF (2014) Form 990-PF (2014) Pace 2 Attached schedules and amounts in the description column Beginning of year End of year Balance Sheets should be for end-of- y ear amounts onl y (See instructions (a) Boo k Va l ue ( b ) Boo k Va l ue (c) Fair M ark et Va l ue 1 Cash-non-interest-bearing ...... 300,142 19 19 2 Savings and temporary cash investments ...... 67,468,964 64,875,770 64,875,770

3 Accounts receivable Ilk, 377,990 Less allowance for doubtful accounts Oil 237,546 377,990 377,990

4 Pledges receivable ► Less allowance for doubtful accounts Oil 5 Grants receivable ...... 6 Receivables due from officers, directors, trustees, and other disqualified persons (attach schedule) (see instructions) . . 7 Other notes and loans receivable (attach schedule)

Less allowance for doubtful accounts ► 8 Inventories for sale or use ...... 9 Prepaid expenses and deferred charges ...... 293,245 256,701 256,701 uti 4 10a Investments-U S and state government obligations (attach schedule) b Investments-corporate stock (attach schedule) . . . . . c Investments-corporate bonds (attach schedule). . . . . 13,627 12,610 12,610

11 Investments-land, buildings, and equipment basis ► Less accumulated depreciation (attach schedule) 12 Investments-mortgage loans ...... 13 Investments-other (attach schedule) ...... 2,088,539,993 2,271,690,561 2,271,690,561 27,958,407 14 Land, buildings, and equipment basis ► Less accumulated depreciation (attach schedule) P, 7,255,504 22,700,674 20,702,903 20,702,903

15 Other assets (describe Ilk- ) 2,190,845 949,805 949,805 16 Total assets (to be completed by all filers-see the instructions Also, see page 1, item I) 2,181,745,036 2,358,866,359 2,358,866,359

17 Accounts payable and accrued expenses ...... 3,552,078 4,312,749

18 Grants payable ...... 345,316,455 387,305,478 19 Deferred revenue ...... 20 Loans from officers, directors, trustees, and other disqualified persons 21 Mortgages and other notes payable (attach schedule) . . .

22 Other liabilities (describe Oil ) 19 22,715,839 Qg 19,087,056 23 Total liabilities (add lines 17 through 22) ...... 371,584,372 410,705,283 Foundations that follow SFAS 117, check here ' F co and complete lines 24 through 26 and lines 30 and 31. r_ 24 U nrestricted ...... 1,810,160,664 1,948,161,076 15 25 Temporarily restricted cor3 +1 26 Permanently restricted ...... Foundations that do not follow SFAS 117, check here u_ and complete lines 27 through 31. 27 Capital stock, trust principal, or current funds ...... 28 Paid-in or capital surplus, or land, bldg , and equipment fund w1 29 Retained earnings, accumulated income, endowment, or other funds

30 Total net assets or fund balances (see instructions) . . . 1,810,160,664 1,948,161,076 Z 31 Total liabilities and net assets / fund balances (see instructions) 2,181,745,036 2,358,866,359 Analysis of Changes in Net Assets or Fund Balances 1 Total net assets or fund balances at beginning of year-Part II, column (a), line 30 (must agree with end-of-year figure reported on prior year's return) ...... 1 1,810,160,664 2 Enter amount from Part I, line 27a ...... 2 -92,157,429 3 Other increases not included in line 2 (itemize) ID 3 230,157,841 4 Add lines 1, 2, and 3 ...... 4 1,948,161,076 5 Decreases not included in line 2 (itemize) Oil 5 6 Total net assets or fund balances at end of year (line 4 minus line 5)-Part II, column (b), line 30 6 1,948,161,076 Form 990-PF (2014) Form 990-PF (2014) Page 3 Ca ital Gains and Losses for Tax on Investment Income (b) How acquired (a) List and describe the kind(s) of property sold (e g , real estate, (c) Date acquired (d) Date sold P-Purchase 2-story brick warehouse, or common stock, 200 shs M LC Co (mo , day, yr (mo , day, yr D-Donation la See Additional Data Table b C d e (f) Depreciation allowed (g) Cost or other basis (h) Gain or (loss) (e) Gross sales price (or allowable) plus expense of sale (e) plus (f) minus (g) a See Additional Data Table b C d e Complete only for assets showing gain in column (h) and owned by the foundation on 12/31/69 (I) Gains (Col (h) gain minus (j) Adjusted basis (k) Excess of col (i) col (k), but not less than -0-) or (i) F M V as of 12/31/69 as of 12/31/69 over col (j), if any Losses (from col (h)) a See Additional Data Table b C d e If gain, also enter in Part I, line 7 2 Capital gain net income or (net capital loss) If (loss), enter -0- in Part I, line 7 2 225,186,543 3 Net short-term capital gain or (loss) as defined in sections 1222(5) and (6)

If gain, also enter in Part I, line 8, column (c) (see instructions) If (loss), enter -0- in Part I, line 8 3 t1 Qualification Under Section 4940(e) for Reduced Tax on Net Investment Income (For optional use by domestic private foundations subject to the section 4940(a) tax on net investment income )

f section 4940( d)(2) applies, leave this part blank

Was the foundation liable for the section 4942 tax on the distributable amount of any year in the base period? fl Yes F No If "Yes," the foundation does not qualify under section 4940 ( e) Do not complete this part

1 Enter the appropriate amount in each column for each year, see instructions before making any entries

(d) Base period years Calendar Distribution ratio Adjusted qualifying distributions Net value of noncharitable-use assets year (or tax year beginning in) (col (b) divided by col (c)) 2013 206,778,839 2,078,519,607 0 099484 2012 202,854,053 1,899,938,089 0 106769 2011 147,308,462 1,917,585,422 0 07682 2010 147,829,209 1,656,513,535 0 089241 2009 69,838,161 1,283,310,957 0 05442 2 Total of line 1, column (d) ...... 2 0 426734 3 Average distribution ratio for the 5-year base period-divide the total on line 2 by 5, or by the number of years the foundation has been in existence if less than 5 years 3 0 085347 4 Enter the net value of noncharitable-use assets for 2014 from Part X, line 5. . . . . 4 2,092,304,588 5 Multiply line 4 by line 3 ...... 5 178,571,920 6 Enter 1% of net investment income (1% of Part I, line 27b)...... 6 2,288,748 7 Add lines 5 and 6 ...... 7 180,860,668 8 Enter qualifying distributions from Part XII, line 4 ...... g 268,003,994 If line 8 is equal to or greater than line 7, check the box in Part VI, line 1b, and complete that part using a 1% tax rate See the Part VI instructions Form 990-PF (2014) Form 990-PF (2014) Page 4 FEMIMF Excise Tax Based on Investment Income (Section 4940 ( a), 4940 ( b), 4940 ( e), or 4948 -see page 18 of the instructions) la Exempt operating foundations described in section 4940(d)(2), check here ► Hand enter "N/A" on line 1 Date of ruling or determination letter ( attach copy of letter if necessary-see instructions) b Domestic foundations that meet the section 4940(e) requirements in Part V, check 1 2,288,748

here ► Rand enter 1% of Part I, line 27b ...... c All other domestic foundations enter 2% of line 27b Exempt foreign organizations enter 4% of Part I, line 12, col (b) 2 Tax under section 511 (domestic section 4947(a)(1) trusts and taxable foundations only Others enter -0-) 2 3 Add lines 1 and 2 ...... 3 2,288,748 4 Subtitle A (income) tax (domestic section 4947(a)(1) trusts and taxable foundations only Others enter -0-) 4 5 Tax based on investment income . Subtract line 4 from line 3 If zero or less, enter -0- . . . . . 5 2,288,748 6 Credits/Payments a 2014 estimated tax payments and 2013 overpayment credited to 2014 6a 2,324,748 b Exempt foreign organizations-tax withheld at source . . . . 6b c Tax paid with application for extension of time to file (Form 8868) . 6c d Backup withholding erroneously withheld ...... 6d 7 Total credits and payments Add lines 6a through 6d ...... 7 2,324,748 8 Enter any penalty for underpayment of estimated tax Check here F if Form 2220 is attached 8

9 Tax due . If the total of lines 5 and 8 is more than line 7, enter amount owed ...... ► 9 10 Overpayment . If line 7 is more than the total of lines 5 and 8, enter the amount overpaid . . . 10 36,000

11 Enter the amount of line 10 to be credited to 2015 estimated tax ► 36,000 Refunded ► 11 Statements Re g ardin g Activities la During the tax year, did the foundation attempt to influence any national, state, or local legislation or did Yes No it participate or intervene in any political campaign? ...... la No b Did it spend more than $100 during the year (either directly or indirectly) for political purposes (see Instructions for definition )? ...... lb No If the answer is "Yes" to la or 1b, attach a detailed description of the activities and copies of any materials published or distributed by the foundation in connection with the activities. c Did the foundation file Form 1120-POL for this year? ...... 1c No d Enter the amount (if any) of tax on political expenditures (section 4955) imposed during the year (1) O n the foundation $ (2) O n foundation managers Ik- $ e Enter the reimbursement (if any) paid by the foundation during the year for political expenditure tax imposed

on foundation managers ► $ 2 Has the foundation engaged in any activities that have not previously been reported to the IRS? . . . . 2 No If "Yes," attach a detailed description of the activities. 3 Has the foundation made any changes, not previously reported to the IRS, in its governing instrument, articles of incorporation, or bylaws, or other similar instruments? If "Yes,"attach a conformed copy of the changes . . 3 No 4a Did the foundation have unrelated business gross income of $1,000 or more during the year? ...... 4a Yes b If "Yes," has it filed a tax return on Form 990-T for this year? ...... 4b Yes 5 Was there a liquidation, termination, dissolution, or substantial contraction during the year? ...... 5 No If "Yes,"attach the statement required by General Instruction T. 6 Are the requirements of section 508(e) (relating to sections 4941 through 4945) satisfied either • By language in the governing instrument, or • By state legislation that effectively amends the governing instrument so that no mandatory directions that conflict with the state law remain in the governing instrument? ...... 6 Yes 7 Did the foundation have at least $5,000 in assets at any time during the year? If "Yes," complete Part II, col. (c), and Part XV...... 7 Yes 8a Enter the states to which the foundation reports or with which it is registered (see instructions) ' DE, NY b If the answer is "Yes" to line 7, has the foundation furnished a copy of Form 990-PF to the Attorney General (or designate) of each state as required by General Instruction G? If "No," attach explanation . 8b Yes 9 Is the foundation claiming status as a private operating foundation within the meaning of section 4942(j)(3) or 4942(j)(5) for calendar year 2014 or the taxable year beginning in 2014 (see instructions for Part XIV )? If "Yes, " complete Part XI V ...... 9 No 10 Did any persons become substantial contributors during the tax year? If "Yes," attach a schedule listing their names and addres ses...... 10 No Form 990-PF (2014) Form 990-PF (2014) Page 5 Statements Re g ardin g Activities (continued) 11 At any time during the year, did the foundation, directly or indirectly, own a controlled entity within the meaning of section 512(b)(13)? If "Yes," attach schedule (see instructions ) 95...... 11 Yes 12 Did the foundation make a distribution to a donor advised fund over which the foundation or a disqualified person had advisory privileges? If "Yes," attach statement (see instructions ) ...... 12 No 13 Did the foundation comply with the public inspection requirements for its annual returns and exemption application? 13 Yes Website address O www simonsfoundation org

14 The books are in care of' FANG HAN Telephone no ' (646) 654-0066

Located at 1111 160 FIFTH AVENUE 7TH FLOOR NEW YORK NY ZIP+4 X 10010

15 Section 4947(a)(1) nonexempt charitable trusts filing Form 990-PF in lieu of Form 1041 -Check here ...... lllk^ F and enter the amount of tax-exempt interest received or accrued during the year ...... I 15

16 At any time during calendar year 2014, did the foundation have an interest in or a signature or other authority over Yes No a bank, securities, or other financial account in a foreign country? 16 Yes See instructions for exceptions and filing requirements for FinCEN Form 114, Report of Foreign Bank and Financial Accounts (FBA R) If "Yes", enter the name of the foreign country lllk^

Statements Re g ardin g Activities for Which Form 4720 Ma y Be Re q uired File Form 4720 if any item is checked in the "Yes" column, unless an exception applies. Yes No la During the year did the foundation (either directly or indirectly) (1) Engage in the sale or exchange, or leasing of property with a disqualified person? fl Yes F No (2) Borrow money from, lend money to, or otherwise extend credit to (or accept it from) a disqualified person? ...... fl Yes F No (3) Furnish goods, services, or facilities to (or accept them from) a disqualified person? F Yes 1 No (4) Pay compensation to, or pay or reimburse the expenses of, a disqualified person? F Yes 1 No (5) Transfer any income or assets to a disqualified person (or make any of either available for the benefit or use of a disqualified person)? ...... fl Yes F No (6) Agree to pay money or property to a government official? ( Exception . Check "No" if the foundation agreed to make a grant to or to employ the official for a period after termination of government service, if terminating within 90 days )...... fl Yes F No b If any answer is "Yes" to la(1 )-(6 ), did any of the acts fail to qualify under the exceptions described in Regulations section 53 4941 (d)-3 or in a current notice regarding disaster assistance (see instructions)? ...... lb No Organizations relying on a current notice regarding disaster assistance check here...... Ok- F_ c Did the foundation engage in a prior year in any of the acts described in 1 a, other than excepted acts, that were not corrected before the first day of the tax year beginning in 2014? ...... 1c No 2 Taxes on failure to distribute income (section 4942) (does not apply for years the foundation was a private operating foundation defined in section 4942(j)(3) or4942(j)(5)) a At the end of tax year 2014, did the foundation have any undistributed income (lines 6d and 6e, Part XIII) for tax year(s) beginning before 2014? ...... 1 Yes F No If "Yes," list the years 20 , 20 , 20 , 20 b Are there any years listed in 2a for which the foundation is not applying the provisions of section 4942(a)(2) (relating to incorrect valuation of assets) to the year's undistributed income? (If applying section 4942(a)(2) to all years listed, answer "No" and attach statement-see instructions ) ...... 2b c If the provisions of section 4942(a)(2) are being applied to any of the years listed in 2a, list the years here lllk^ 20 , 20 , 20 , 20 3a Did the foundation hold more than a 2% direct or indirect interest in any business enterprise at any time during the year? ...... fl Yes F No b If "Yes," did it have excess business holdings in 2014 as a result of (1) any purchase by the foundation or disqualified persons after May 26, 1969, (2) the lapse of the 5-year period (or longer period approved by the Commissioner under section 4943(c)(7 )) to dispose of holdings acquired by gift or bequest, or (3) the lapse of the 10-, 15-, or 20-year first phase holding period? (Use Schedule C, Form 4720, to determine if the foundation had excess business holdings in 2014 .)...... 3b 4a Did the foundation invest during the year any amount in a manner that would jeopardize its charitable purposes? 4a No b Did the foundation make any investment in a prior year (but after December 31, 1969) that could jeopardize its charitable purpose that had not been removed from jeopardy before the first day of the tax year beginning in 20147 4b No Form 990-PF (2014) Form 990-PF (2014) Page 6 Statements Re g ardin g Activities for Which Form 4720 Ma y Be Re q uired (continued) 5a During the year did the foundation pay or incur any amount to (1) Carry on propaganda, or otherwise attempt to influence legislation (section 4945(e))? fl Yes F No (2) Influence the outcome of any specific public election (see section 4955), or to carry on, directly or indirectly, any voter registration drive? ...... fl Yes F No (3) Provide a grant to an individual for travel, study, or other similar purposes? 1 Yes F No (4) Provide a grant to an organization other than a charitable, etc , organization described in section 4945(d)(4)(A)? (see instructions) ...... F Yes 1 No (5) Provide for any purpose other than religious, charitable, scientific, literary, or educational purposes, or for the prevention of cruelty to children or animals?...... (- Yes F No b If any answer is "Yes" to 5a(1 )-(5 ), did any of the transactions fail to qualify under the exceptions described in Regulations section 53 4945 or in a current notice regarding disaster assistance (see instructions)? ...... 5b No Organizations relying on a current notice regarding disaster assistance check here...... (- c If the answer is "Yes" to question 5a(4), does the foundation claim exemption from the tax because it maintained expenditure responsibility for the grant?...... F Yes (- No If "Yes," attach the statement required by Regulations section 53.4945-5(d). 6a Did the foundation, during the year, receive any funds, directly or indirectly, to pay premiums on a personal benefit contract? ...... fl Yes F No b Did the foundation, during the year, pay premiums, directly or indirectly, on a personal benefit contract? . . . . 6b No If "Yes" to 6b, file Form 8870. 7a At any time during the tax year, was the foundation a party to a prohibited tax shelter transaction? 1 Yes F No b If yes, did the foundation receive any proceeds or have any net income attributable to the transaction? . . . . 7b Information About Officers, Directors, Trustees, Foundation Managers, Highly Paid Employees, and Contractors 1 List all officers, directors, trustees, foundation managers and their compensation ( see instructions). (b) Title, and average (c) Compensation (d) Contributions to (e) Expense account, (a) Name and address hours per week ( If not paid , enter employee benefit plans other allowances devoted to position -0-) and deferred compensation See Additional Data Table

2 Compensation of five highest -paid employees ( other than those included on line 1-see instructions). If none, enter " NONE." ( d) Contributions to (b) Title, and average (a) Name and address of each employee employee benefit (e) Expense account, hours per week (c) Compensation paid more than $ 50,000 plans and deferred other allowances devoted to position compensation LOUIS REICHARDT DIRECTOR SFARI 546,250 49,639 0 40 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010 ALEX LASH CHIEF INFORMATICS 422,815 58,642 0 40 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010 LESLIE GREENGARD DIRECTOR SCDA 383,333 23,122 0 0 160 FIFTH AVENUE 7TH FLOOR 26 NEWYORK,NY 10010 ABRAHAM LACKMAN OFF CIVIC AFFAIRS 350,000 27,115 0 32 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010 MARION GREENUP VICE PRES - ADMIN 337,801 42,176 0 40 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010

Total number of other employees paid over $50 ,000 ...... ► 73 Form 990-PF (2014) Form 990-PF (2014) Page 7 Information About Officers, Directors, Trustees , Foundation Managers , Highly Paid Employees, and Contractors (continued) 3 Five highest -paid independent contractors for professional serv ices (see instructions ). If none, enter "NONE". (a) Name and address of each person paid more than $50,000 (b) Type of service (c) Compensation Prometheus Research LLC Research Consulting 2,789,169 55 Church Street 7th Floor NEWHAVEN,CT 06510 Mindspec Inc Research Consulting 990,880 8280 Greensboro Dr Suite 150 MCLEAN,VA 22102 Psychogenics Inc research consulting 198,033 765 Old Saw Mill River Road TARRYTOWN,NY 10591 Two Turtle Productions LLC Video Production 229,688 19 El Sereno Ct SAN FRANCISCO,CA 94127 Accountemps Temporary Staff 219,346 12400 Collections Center Drive CHICAGO,IL 60693 Total number of others receiving over $ 50,000 for professional services. 34 Summary of Direct Charitable Activities

List the foundation's four largest direct charitable activities during the tax year Include relevant statistical information such as the number of organizations and other beneficiaries served, conferences convened, research papers produced, etc Expenses 1SEE ATTACHMENT 19 14,921,723 2SEE ATTACHMENT 19 2,610,537 3SEE ATTACHMENT 19 2,254,027 4SEE ATTACHMENT 19 1,633,398 OWNW. Summar y of Pro g ram - Related Investments ( see instructions ) Describe the two largest program-related investments made by the foundation during the tax year on lines 1 and 2 A mount 1

2

All other program-related investments See instructions 3

Total . Add lines 1 through 3 ...... ► Form 990-PF (2014) Form 990-PF (2014) Page 8 Minimum Investment Return (All domestic foundations must complete this part. Foreign foundations, see instructions. ) 1 Fair market value of assets not used (or held for use) directly in carrying out charitable, etc , purposes a Average monthly fair market value of securities ...... la 2,013,439,062 b Average of monthly cash balances ...... lb 110,728,032 c Fair market value of all other assets (see instructions) ...... 1c 0 d Total (add lines la, b, and c) ...... ld 2,124,167,094 e Reduction claimed for blockage or other factors reported on lines la and 1c (attach detailed explanation) ...... le 2 Acquisition indebtedness applicable to line 1 assets ...... 2 0 3 Subtract line 2 from line ld ...... 3 2,124,167,094 4 Cash deemed held for charitable activities Enter 1 1/2% of line 3 (for greater amount, see instructions) ...... 4 31,862,506 5 Net value of noncharitable -use assets . Subtract line 4 from line 3 Enter here and on Part V, line 4 5 2,092,304,588 6 Minimum investment return . Enter 5% of line 5 ...... 6 104,615,229 Distributable Amount (see instructions) (Section 49420)(3) and 0)(5) private operating foundations and certain forei g n org anizations check here f and do not com p lete this p art. ) 1 Minimum investment return from Part X, line 6 ...... 1 104,615,229 2a Tax on investment income for 2014 from Part VI, line 5...... 2a 2,288,748 b Income tax for 2014 (This does not include the tax from Part VI ). . 2b c Add lines 2a and 2b ...... 2c 2,288,748 3 Distributable amount before adjustments Subtract line 2c from line 1...... 3 102,326,481 4 Recoveries of amounts treated as qualifying distributions ...... 4 1,435,259 5 Add lines 3 and 4 ...... 5 103,761,740 6 Deduction from distributable amount (see instructions ) ...... 6 7 Distributable amount as adjusted Subtract line 6 from line 5 Enter here and on Part XIII, line 1. . 7 103,761,740

Qualifying Distributions (see instructions)

1 Amounts paid (including administrative expenses) to accomplish charitable, etc , purposes a Expenses, contributions, gifts, etc -total from Part I, column (d), line 26...... la 268,003,994 b Program-related investments-total from Part IX-B ...... lb 0 2 Amounts paid to acquire assets used (or held for use) directly in carrying out charitable, etc , purposes ...... 2 0 3 Amounts set aside for specific charitable projects that satisfy the a Suitability test (prior IRS approval required) ...... 3a 0 b Cash distribution test (attach the required schedule) ...... 3b 0 4 Qualifying distributions. Add lines la through 3b Enter here and on Part V, line 8, and Part XIII, line 4 4 268,003,994 5 Foundations that qualify under section 4940(e) for the reduced rate of tax on net investment income Enter 1% of Part I, line 27b (see instructions) ...... 5 2,288,748 6 Adjusted qualifying distributions . Subtract line 5 from line 4 ...... 6 265,715,246 Note : The amount on line 6 will be used in Part V, column (b), in subsequent years when calculating whether the foundation qualifies for the section 4940(e) reduction of tax in those years Form 990-PF (2014) Form 990-PF (2014) Page 9 « Undistributed Income (see instructions) (a) (b) (c) (d) Corpus Years prior to 2013 2013 2014 1 Distributable amount for 2014 from Part XI, line 7 103, 761, 740 2 Undistributed income, if any, as of the end of 2014 a Enter amount for 2013 only...... 0 b Total for prior years 2012 , 2011 , 2010 0 3 Excess distributions carryover, if any, to 2014 a From 2009. . . . 37,491,69 b From 2010. . . . 65,394,87 c From 2011...... d From 2012. . . . . e From 2013. . . . 102,400,87 f Total of lines 3a through e...... 205,287,445 4 Qualifying distributions for 2014 from Part XII, line 4 11111 $ 268,003,994 a Applied to 2013, but not more than line 2a 0 b Applied to undistributed income of prior years (Election required-see instructions). . . . . c Treated as distributions out of corpus (Election required-see instructions)...... d Applied to 2014 distributable amount. . . . . 103, 761, 740 e Remaining amount distributed out of corpus 164, 242, 254 5 Excess distributions carryover applied to 2014 (If an amount appears in column (d), the same amount must be shown in column (a).) 6 Enter the net total of each column as indicated below: a Corpus Add lines 3f, 4c, and 4e Subtract line 5 369, 529, 699 b Prior years' undistributed income Subtract line 4b from line 2b ...... 0 c Enter the amount of prior years' undistributed income for which a notice of deficiency has been issued, or on which the section 4942(a) tax has been previously assessed...... d Subtract line 6c from line 6b Taxable amount -see instructions ...... 0 e Undistributed income for 2013 Subtract line 4a from line 2a Taxable amount-see instructions ...... 0 f Undistributed income for 2014 Subtract lines 4d and 5 from line 1 This amount must be distributed in 2015 ...... 0 7 Amounts treated as distributions out of corpus to satisfy requirements imposed by section 170(b)(1)(F) or4942(g)(3) (Election may be required - see instructions) ...... 8 Excess distributions carryover from 2009 not 37, 491, 693 applied on line 5 or line 7 (see instructions) . . . 9 Excess distributions carryover to 2015. Subtract lines 7 and 8 from line 6a ...... 332, 038, 006 10 Analysis of line 9 a Excess from 2010. . . . 65,394,87 b Excess from 2011. . . . c Excess from 2012. . . . d Excess from 2013. . . . 102,400,87 e Excess from 2014. . . . 164,242,25- Form 990-PF (2014) Form 990-PF (2014 ) Page 10 « Private O p eratin g Foundations ( see instructions and Part VII-A q uestion 9 ) la If the foundation has received a ruling or determination letter that it is a private operating foundation, and the ruling is effective for 2014, enter the date of the ruling......

b Check box to indicate whether the organization is a private operating foundation described in section F 4942(j)(3) or F 4942(])(5) 2a Enter the lesser of the adjusted net Tax year Prior 3 years ( income from Part I or the minimum e) Total (a) 2014 (b) 2013 (c) 2012 (d) 2011 investment return from Part X for each year listed ...... b 85% of line 2a ...... c Qualifying distributions from Part XII, line 4 for each year listed . . . . . d Amounts included in line 2c not used directly for active conduct of exempt activities ...... e Qualifying distributions made directly for active conduct of exempt activities Subtract line 2d from line 2c . . . . 3 Complete 3a, b, or c for the alternative test relied upon a "Assets" alternative test-enter (1) Value of all assets ...... (2) Value of assets qualifying under section 4942(j)(3)(B)(i) b "Endowment" alternative test- enter 2/3 of minimum investment return shown in Part X, line 6 for each year listed. . . c "Support" alternative test-enter (1) Total support other than gross investment income (interest, dividends, rents, payments on securities loans (section 512(a)(5)), or royalties) . . . . (2) Support from general public and 5 or more exempt organizations as provided in section 4942(j)(3)(B)(iii). . . . (3) Largest amount of support from an exempt organization (4) Gross investment income Supplementary Information ( Complete this part only if the organization had $5 , 000 or more in assets at any time during the year -see instructions.) 1 Information Regarding Foundation Managers: a List any managers of the foundation who have contributed more than 2% of the total contributions received by the foundation before the close of any tax year (but only if they have contributed more than $5,000) (See section 507(d)(2) )

JAMES SIMONS b List any managers of the foundation who own 10% or more of the stock of a corporation (or an equally large portion of the ownership of a partnership or other entity) of which the foundation has a 10% or greater interest

NONE 2 Information Regarding Contribution , Grant , Gift, Loan, Scholarship, etc., Programs: Check here if the foundation only makes contributions to preselected charitable organizations and does not accept unsolicited requests for funds If the foundation makes gifts, grants, etc (see instructions) to individuals or organizations under other conditions, complete items 2a, b, c, and d

a The name, address, and telephone number or email address of the person to whom applications should be addressed

b The form in which applications should be submitted and information and materials they should include

c Any submission deadlines

d Any restrictions or limitations on awards, such as by geographical areas, charitable fields, kinds of institutions, or other factors

Form 990-PF (2014) Form 990-PF (2014) Page 11 Supplementary Information (continued) 3 Grants and Contributions Paid During the Year or Approved for Future Payment If recipient is an individual , Recipient Foundation show any relationship to Purpose of grant or status o f Amount any foundation manager contribution Name and address (home or business ) recipient or substantial contributor a Paid during the year TOTAL GRANTS PAID see statement see statement 15 232,372,215 15 attached See statement 15 See statement , NY 10010

Total...... ► 3a 232,372,215 b Approved for future payment TOTAL GRANTS APPROVED see See statement 16 207,623,607 statement 16 attached See statement 16 see statement , NY 10010

Total ...... ► 3b 207,623,607 Form 990-PF (2014) Form 990-PF (2014) Page 12 Anal y sis of Income - Producin g Activities Enter gross amounts unless otherwise indicated Unrelated business income Excluded by section 512, 513, or 514 (e) Related or exempt (a) (b) (c) (d ) function income Business 1 Program service revenue Amount Exclusion code Amount (See code instructions a b c d e f g Fees and contracts from government agencies 2 Membership dues and assessments. . . . 3 Interest on savings and temporary cash investments ...... 14 26,885 4 Dividends and interest from securities. . . . 5 Net rental income or (loss) from real estate a Debt-financed property...... b Not debt-financed property. . . . . 16 1,368,688 6 Net rental income or (loss) from personal property ...... 7 Other investment income. . . . . 8 Gain or (loss) from sales of assets other than inventory ...... 525990 1,046,807 18 197,924,676 9 Net income or (loss) from special events 10 Gross profit or (loss) from sales of inventory. 11 Otherrevenue a b c d e 12 Subtotal Add columns (b), (d), and (e). 1,046,807 199,320,249 13 Total . Add line 12, columns (b), (d), and (e) ...... 13 200,367,056 (See worksheet in line 13 instructions to verify c alculations ) nshi p of Activities to the Accom p lishment of Exem pt Pur p oses Explain below how each activity for which income is reported in column (e) of Part XVI-A contributed importantly to Line No. the accomplishment of the foundation's exempt purposes (other than by providing funds for such purposes) (See instructions

Form 990-PF (2014) Form 990-PF (2014) Page 13 Information Regarding Transfers To and Transactions and Relationships With Noncharitable Exempt Organizations 1 Did the organization directly or indirectly engage in any of the following with any other organization described in section 501(c) of the Code (other than section 501(c)(3) organizations) or in section 527, relating to political Yes No organizations? a Transfers from the reporting foundation to a noncharitable exempt organization of (1) Cash ...... la(1) No (2) Other assets ...... la(2) No b Other transactions (1) Sales of assets to a noncharitable exempt organization ...... lb(1) No (2) Purchases of assets from a noncharitable exempt organization ...... lb(2) No (3) Rental of facilities, equipment, or other assets ...... lb(3) No (4) Reimbursement arrangements ...... lb(4) No (5) Loans or loan guarantees ...... lb(5) No (6) Performance of services or membership or fundraising solicitations ...... lb(6) No c Sharing of facilities, equipment, mailing lists, other assets, or paid employees ...... 1c No d If the answer to any of the above is "Yes," complete the following schedule Column (b) should always show the fair market value of the goods, other assets, or services given by the reporting foundation If the foundation received less than fair market value in any transaction or sharing arrangement, show in column (d) the value of the goods, other assets, or services received

2a Is the foundation directly or indirectly affiliated with, or related to, one or more tax-exempt organizations described in section 501 ( c) of the Code ( other than section 501 ( c)(3)) or in section 527?...... f Yes FNo b If "Yes," complete the following schedule (a) Name of organization (b) Type of organization (c) Description of relationship

Under penalties of perjury, I declare that I have examined this return, including accompanying schedules and statements, and to the best of my knowledge and belief, it is true, correct, and complete Declaration of preparer (other than taxpayer) is based on all information of which preparer has any knowledge Signn ****** 2015-08-06 Here

Signature of officer or trustee Date

Print/Type preparer's name Preparer's Signature ScottThompsett rais Firm's name 0- Prepare GRANT THORNTON LLP Use Firm's address Only 0- 757 THIRD AVE 4TH FLOOR NEW YORK, NY 100172013 Form 990PF Part IV - Capital Gains and Losses for Tax on Investment Income - Columns a - d

(a) List and describe the kind (s) of property sold (e g , real estate, (b) How (c) Date acquired ( d) Date sold 2-story brick warehouse , or common stock, 200 shs MLC Co acquired (mo , day, yr (mo , day, yr P-Purchase D-Donation

S-T CAPITAL GAIN FROM LPS P

L-T CAPITAL GAIN FROM LPS P

LESS L-T CAPITAL GAIN FROM UBTI

LESS S-T CAPITAL GAIN FROM UBTI

LESS 1231/1250 GAIN FROM UBTI

HEDGE FUND 1 INVESTMENT

HEDGE FUND 2 INVESTMENT

HEDGE FUND 3 INVESTMENT

PUBLICLY TRADED SECURITIES

HEDGE FUND 4 INVESTMENT Form 990PF Part IV - Capital Gains and Losses for Tax on Investment Income - Columns e - h

(e) Gross sales price ( f) Depreciation allowed (g) Cost or other basis ( h) Gain or (loss) (or allowable) plus expense of sale (e) plus (f) minus (g)

2,893,482 -2,893,482

103,137,187 103,137,187

-110,566

-10,472

-925,425

340,000,000 271,114,206 68,885,794

193,175 41,998 151,177

8,000,000 3,735,534 4,264,466

22,943,560 2,882,392 20,061,168

101,418,533 68,791,837 32,626,696 Form 990PF Part IV - Capital Gains and Losses for Tax on Investment Income - Columns i - Form 990PF Part VIII Line 1 - List all officers, directors, trustees, foundation managers and their compensation

(a) Name and address (b) Title, and average (c) Compensation (d) Contributions to (e) Expense account, hours per week (If not paid, enter employee benefit plans other allowances devoted to position -0-) and deferred compensation

Marilyn Simons president /director 0 0 0 30 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010

James Simons chairman of the board 0 0 0 10 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010

Mark Silber director 0 0 0 10 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010

Maria Adler 95 cfo /treasurer/secretary 304,021 58,521 0 32 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010

Gerald Fischbach ID director/Chief Scientist 597,728 37,384 0 40 0 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010

David Eisenbud Director 0 0 0 10 160 FIFTH AVENUE 7TH FLOOR NEWYORK,NY 10010 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Accounting Fees Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Category Amount Net Investment Adjusted Net Disbursements for Income Income Charitable Purposes

BDO SEIDMAN, LLP 76,500 93,500

GRANT THORNTON, LLP 76,050 33,250 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Compensation Explanation

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Person Explanation Name

Gerald CHIEF SCIENTIST, GERALD FISCHBACH, UNDERTAKES A DUAL ROLE AT THE SIMONS FOUNDATION THE COMPENSATION Fischbach REPORTED ON THE FORM 990-PF IS PAID FOR SERVICES RENDERED AS AN EMPLOYEE OF THE FOUNDATION DR FISCHBACH IS NOT COMPENSATED IN HIS CAPACITY AS A BOARD DIRECTOR defile GRAPHIC print - DO NOT PROCESS I As Filed Data - I DLN: 93491317013405

Note: To capture the full content of this document, please select landscape mode (11" x 8.5") when printing. TY 2014 Depreciation Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Investments - Other Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Category / Item Listed at Cost or Book Value End of Year Fair FMV Market Value HEDGE FUNDS FMV 824,656,899 824,656,899 PRIVATE EQUITY FUNDS FMV 168,085,642 168,085,642 INVESTMENT IN SUBSIDIARY FMV 1,278,948,020 1,278,948,020 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Legal Fees Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Category Amount Net Investment Adjusted Net Disbursements for Income Income Charitable Purposes

COOLEY LLP 69,350 65,677

LOEB, BLOCK & PARTNERS 73,589 74,965

FRAGOMEN, DEL REY, 32,443 43,081 BE RN SE N,

LOEWY, LLP

BRO DY & BROWN, LLP 16,936 17,170

SCHANER & LUBITZ, PLLC 15,500 18,800 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Other Assets Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Description Beginning of Year - End of Year - Book End of Year - Fair Book Value Value Market Value

DUE FROM BROKER 254,085 211,942 211,942

DUE FROM THIRD PARTIES 1,936,760 737,863 737,863 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Other Expenses Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Description Revenue and Expenses Net Investment Adjusted Net Income Disbursements for per Books Income Charitable Purposes

INFORMATION TECHNOLOGY 1,463,081 1,416,308

RENTAL EXPENSES (SUBLEASE) 1,235,247 1,235,247

COMMUNICATION EXPENSES 1,234,937 1,290,826

INVESTMENT EXPENSES FROM LPS 9,239,991

OFFICE EXPENSES 512,019 785,247

PROGRAMMATIC EXPENDITURES 7,787,370 7,650,904

HONORARIUM EXPENSES 383,273 383,273

CT CORPORATION SYSTEM 284 284 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Other Income Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Description Revenue And Net Investment Adjusted Net Income Expenses Per Books Income

Ordinary Income from Investments in 12,812,799

Limited Partnerships

Unrelated Business Income (Investment) -44,834

reported on Form 990-T l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Other Increases Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Description Amount UNREALIZED GAINS ON INVESTMENT 34,282,340 NET UNREALIZED GAIN ON INVESTMENT IN 195,875,501 100% OWNED SUBSIDIARY 0 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Other Liabilities Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Description Beginning of Year - End of Year - Book Book Value Value DEFERRED EXCISE TAX LIABILITY 12,656,470 14,435,381 DEFERRED RENT LIABILITY 10,059,369 4,651,675 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Other Professional Fees Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Category Amount Net Investment Adjusted Net Disbursements for Income Income Charitable Purposes

HUMAN RESOURCES 128,254 125,132 CONSULTING

RECRUITING FEES 62,102 58,785

EMPLOYEE 29,360 28,190 TRAINING/DEVELOPMENT

PAYROLL SERVICES 20,531 20,518

MISCELLANEOUS 124,239 133,442 CONSULTING l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Taxes Schedule

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Category Amount Net Investment Adjusted Net Disbursements for Income Income Charitable Purposes

FEDERAL EXCISE TAXES 2,852,035

UNRELATED BUSINESS INCOME TAXE 17,500 l efile GRAPHIC p rint - DO NOT PROCESS As Filed Data - DLN: 93491317013405

TY 2014 Tra nsfersToControlled Entities

Name : THE SIMONS FOUNDATION INC EIN: 13-3794889

Name us / EIN Description Amount Foreign Address

Helicoid Investment C/O HAMILTON TRUST 99-0688931 capital contribution 0 limited MGMT CO LTD PALM GROVE HOUSE ROAD TOWN, TORTOLA, BVI vq CJ

Clinical Research 160 FIFTH AVENUE 7TH 46-3285474 CAPITAL 1,550,000 Associates LLC FLOOR CONTRIBUTION NEW YORK, NY 10010

Foundation 160 FIFTH AVENUE 7TH 46-3285543 CAPITAL 1,000,000 Associates LLC FLOOR CONTRIBUTION NEW YORK, NY 10010

Total 2,550,000 efile GRAPHIC print - DO NOT PROCESS As Filed Data - DLN: 93491317013405 Schedule B Schedule of Contributors OMB No 1545-0047 (Form 990 , 990-EZ, or 990 -PF) ► Attach to Form 990, 990-EZ, or 990 -PF. 2 014 Department of the Treasury ► Information about Schedule B (Form 990 , 990-EZ , or 990 -PF) and its instructions is at Internal Revenue Serwce . goy/form990 . Name of the organization Employer identification number THE SIMONS FOUNDATION INC 13-3794889 Organization type (check one)

Filers of: Section:

Form 990 or 990-EZ r 501(c)( ) (enter number) organization

r 4947( a)(1) nonexempt charitable trust not treated as a private foundation

r 527 political organization

Form 990-PF F 501( c)(3) exempt private foundation

r 4947( a)(1) nonexempt charitable trust treated as a private foundation

r 501(c)( 3) taxable private foundation

Check if your organization is covered by the General Rule or a Special Rule. Note . Only a section 501(c)(7), (8), or (10) organization can check boxes for both the General Rule and a Special Rule See instructions

General Rule

F For an organization filing Form 990, 990-EZ, or 990-PF that received, during the year, contributions totaling $5,000 or more (in money or other property) from any one contributor Complete Parts I and II See instructions for determining a contributor's total contributions

Special Rules

fl For an organization described in section 501 ( c)(3) filing Form 990 or 990- EZ that met the 331/3% support test of the regulations under sections 509(a )(1) and 170(b)(1)(A)(vi), that checked Schedule A ( Form 990 or 990-EZ), Part II, line 13, 16a, or 16b, and that received from any one contributor , during the year , total contributions of the greater of (1) $5 , 000 or (2) 2% of the amount on (i) Form 990, Part VIII, line 1h , or (u) Form990- EZ, line 1 Complete Parts I and II

fl For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor, during the year, total contributions of more than $1,000 exc/us/ve/yfor religious, charitable, scientific, literary, or educational purposes, or for the prevention of cruelty to children or animals Complete Parts I, II, and III

For an organization described in section 501(c)(7), (8), or (10) filing Form 990 or 990-EZ that received from any one contributor, during the year, contributions exc/us/ve/yfor religious, charitable, etc , purposes, but no such contributions totaled more than $1,000 this box is checked, enter here the total contributions that were received during the year for an exclusively religious, charitable, etc , purpose Do not complete any of the parts unless the General Rule applies to this organization because it received nonexclusively religious, charitable, etc , contributions totaling $5,000 or more during the year ...... $

Caution . An organization that is not covered by the General Rule and/or the Special Rules does not file Schedule B (Form 990, 990-EZ, or 990-PF), but it must answer "No" on Part IV, line 2, of its Form 990, or check the box on line H of its Form 990-EZ or on its Form 990PF, Part I, line 2, to certify that it does not meet the filing requirements of Schedule B (Form 990, 990-EZ, or 990-PF)

For Paperwork Reduction Pct Notice , see the Instructions Cat No 30613X Schedule B (Form 990 , 990-EZ , or 990-PF) (2014) for Form 990 , 990-EZ , or 990-PF Schedule B (Form 990, 990-EZ, or 990-PF) (2014) Page 2 Name of organization Employer identification number THE SIMONS FOUNDATION INC 13-3794889

Contributors ( see instructions) Use duplicate copies of Part I if additional space is needed (a) (b) (c) (d) No. Name , address , and ZIP + 4 Total contributions Type of contribution

1 Person James Simons Payroll 160 5th Avenue 7th Floor $ 23,137,304 Noncash F

New York, NY 10010 (Complete Part II for noncash contributions )

(a) (b) (c) (d) No. Name , address , and ZIP + 4 Total contributions Type of contribution

Person Payroll $ Noncash r

(Complete Part II for noncash contributions )

(a) (b) (c) (d) No. Name, address , and ZIP + 4 Total contributions Type of contribution

Person Payroll $ Noncash r

(Complete Part II for noncash contributions )

(a) (b) (c) (d) No. Name, address , and ZIP + 4 Total contributions Type of contribution

Person Payroll $ Noncash r

(Complete Part II for noncash contributions )

(a) (b) (c) (d) No. Name , address , and ZIP + 4 Total contributions Type of contribution

Person Payroll $ Noncash r

(Complete Part II for noncash contributions )

(a) (b) (c) (d) No. Name , address , and ZIP + 4 Total contributions Type of contribution

Person Payroll $ Noncash r

(Complete Part II for noncash contributions

Schedule B (Form 990, 990-EZ, or 990-PF) (2014) Schedule B (Form 990, 990-EZ, or 990-PF) (2014) Page 3 Name of organization Employer identification number THE SIMONS FOUNDATION INC 13-3794889

Noncas h Property (see instructions) Use duplicate copies of Part II if additional space is needed

(a) No. (b) (c) (d) from Description of noncash property given FMV (or estimate) Date received Part I (see instructions )

1

Publicly Traded Securities $ 23,137,304

(a) No. (b) (c) (d) from Description of noncash property given FMV ( or estimate) Date received Part I (see instructions )

$

(a) No. (b) (c) (d) from Description of noncash property given FMV ( or estimate) Date received Part I ( see instructions)

$

(a) No. (b) (c) (d) from Description of noncash property given FMV (or estimate) Date received Part I ( see instructions )

$

(a) No. (b) (c) (d) from Description of noncash property given FMV (or estimate) Date received Part I ( see instructions)

$

(a) No. (b) (c) (d) from Description of noncash property given FMV ( or estimate) Date received Part I (see instructions)

$

Schedule B (Form 990, 990-EZ, or 990-PF) (2014) Schedule B (Form 990, 990-EZ, or 990-PF) (2014) Page 4 Name of organization Employer identification number THE SIMONS FOUNDATION INC 13-3794889 Exclusively religious , charitable , etc., contributions to organizations described in section 501(c)(7), (8), or (10) that total more than $1 , 000 for the year from any one contributor . Complete columns (a) through ( e) and the following line entry For organizations completing Part III, enter the total of exclusively religious, charitable, etc , contributions of $1,000 or less for the year (Enter this information once See instructions ) $ Use duplicate copies of Part III if additional space is needed (a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift Transferee's name, address, and ZIP 4 Relationship of transferor to transferee

(a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift Transferee's name, address, and ZIP 4 Relationship of transferor to transferee

(a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift Transferee's name, address, and ZIP 4 Relationship of transferor to transferee

(a) No. from (b) Purpose of gift (c) Use of gift (d) Description of how gift is held Part I

(e) Transfer of gift Transferee's name, address, and ZIP 4 Relationship of transferor to transferee

Schedule B (Form 990, 990-EZ, or 990-PF) (2014) THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

2014 Grants Paid

Recipient Name Recipient Address Status Purpose of Grant Amount Paid Tulane University Office of Research Admin 7029 A Freret Street Administrators of the Tulane Educational Fund New Orleans LA 70118 PC Collaboration Grant for Mathematicians at Tulane University 7,000 00 Tulane University Office of Research Admin 7029 A Freret Street Administrators of the Tulane Educational Fund New Orleans LA 70118 PC Ordinary and symbolic powers of homogeneous ideals 7,00000 141E College Ave Agnes Scott College Decatur GA 30030 PC Index systems and topological dynamics 7,00000 2950 Hobson Way Air Force Institute of Technology WPAFB OH 45433 PC Overturned Traveling Waves 7,000.00 1300 Morris Park Avenue Belfer 312 Albert Einstein College of Medicine, Inc Bronx NY 10461 PC Nonlinear Elliptic PDEs and Integral Systems 7,00000 Norton's Woods 136 Irving Street American Academy of Arts and Sciences Cambridge MA 02138 PC AAAS Annual Fund 25,000 00 201 Charles Street American Mathematical Society Providence RI 02904 PC AMS-Simons Travel Grants 294,000 00 5808 13th Ave American Modeling Teachers Association Sacramento CA 95820 PC AMTA/STEMteachersNYC Modeling Instruction Workshops Gift 120,000 00 9037 Ron Den Lane American Society for Neurochemistry Windermere FL 34786 PC 45th Annual Meeting 6,00000 Office for Research & Sponsored Projects Admin PO Box 876011 Arizona Board of Regents for and on behalf of Arizona State University Tempe AZ 85287-6011 PC Investigating TNA as a Candidate RNA Progenitor 82,000 00 P O Box 210158, Room 510 Arizona Board of Regents, University of Arizona Tucson AZ 85721-0158 PC From Integrable Systems to Hyperkaehler Geometry via String Theory 7,000 00 P O Box 210158, Room 510 Arizona Board of Regents, University of Arizona Tucson AZ 85721-0158 PC Group Representations and Applications 99,360 00 P O Box 210158, Room 510 Arizona Board of Regents, University of Arizona Tucson AZ 85721-0158 PC Many-Body Quantum Systems Dynamics and Ground States 77,479 00 P O Box 210158, Room 510 Arizona Board of Regents, University of Arizona Tucson AZ 85721-0158 PC Modular symbols in Iwasawa theory 92,477 00 P O Box 2260 Arizona State University Foundation Tempe AZ 85280-2260 PC Complex hyperbolic discrete groups and lattices 7,00000 700 W Gillespie Street Aspen Center for Physics Aspen CO 81611 PC Aspen Summer Program 100,000 00 10 Shattuck Street, Suite 249 Autism Consortium Boston MA 02115 PC Bridging Basic Research with Clinical Research with the Aim of Discovering B 128,678 50 28 West 39th Street, #502 Autism Science Foundation New York NY 10018 PC Building awareness of the value of brain tissue donation for autism research 180,330 00 2000 University Avenue Ball State University Muncie IN 47306 PC Collaboration Grant n Complex Dynamics 7,00000 2000 University Avenue Ball State University Muncie IN 47306 PC Collaboration Grant Proposal 7,00000 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

PO Box 5000 Bard College Annandale on Hudson NY 12504-5000 PC Supersymmetry and K-Theory 7,000 00 3009 Broadway Barnard College New York NY 10027 PC Braids, links and mapping class groups 7,00000 One Bernard Baruch Way Box J-1010 Baruch College, The City University of New York New York NY 10010-5585 PC Random walks and diffusions in random environments 7,000 00 One Bernard Baruch Way Box J-1010 Baruch College, The City University of New York New York NY 10010-5585 PC Stochastic processes in random environments 92,644 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC Catching fireflies Dynamic neural computations for foraging 100,000 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC Hippocampal mechanisms of social learning in animal models of Autism 125,000 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC Motor cortex plasticity in MeCP2 duplication syndrome 62,500 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC MULTISENSORY PROCESSING IN AUTISM 60,000 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC Simons Simplex Collection Support Grant 10,000 00 One Bear Place #97360 Baylor University Waco TX 76798-7360 PC Harmonic Analysis Geometric Maximal Operators and the Halo Conjecture 7,00000 Peking University, Beijing, 100871, BICMR, Peking University China NC Beijing International Center for Mathematical Research (BICMR) & SCGP Visi 65,261 70 Birkbeck College Ma let Street Birkbeck College London, N/AW C1E 7HX NC Developing fNIRS as a brain function indicator in at-risk infants 290,707 00 151 Whittier Research Center 2200 Vine Street Board of Regents of the University of Nebraska, University of Nebraska-Lincoln Lincoln NE 68583-0861 PC Collaboration Grant for Mathematicians at Nebraska---Roger Wiegand 7,00000 151 Whittier Research Center 2200 Vine Street Board of Regents of the University of Nebraska, University of Nebraska-Lincoln Lincoln NE 68583-0861 PC Operator Algebras and Extensions of Inverse Semigroups 7,000 00 151 Whittier Research Center 2200 Vine Street Board of Regents of the University of Nebraska, University of Nebraska-Lincoln Lincoln NE 68583-0861 PC Singularity categories, K-theory and A-infinity-algebras 7,000 00 151 Whittier Research Center 2200 Vine Street Board of Regents of the University of Nebraska, University of Nebraska-Lincoln Lincoln NE 68583-0861 PC Studies in commutative algebra 7,000 00 204 Ross Hall Mailstop 325 Board of Regents, NSHE, obo University of Nevada, Reno Reno NV 89557-0240 PC Heegaard Floer homology and Dehn surgery obstructions 7,000.00 204 Ross Hall Mailstop 325 Board of Regents, NSHE, obo University of Nevada, Reno Reno NV 89557-0240 PC Sabbatical leave support in theoretical atomic physics 89,549 00 1 University Circle Board of Trustees of Western Illinois University Macomb IL 61455 PC Valued o-minimal fields, measures, and residue field domination 7,00000 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

300 Longwood Avenue Boston Childrens Hospital Boston MA 02115 PC Mechanical characterization of brain tissue and individual neurons in Autism 41,902 00 5800 College Station Bowdoin College Brunswick ME 04530 PC Geometry and quasi-isometry classification of some self-similar groups 7,00000 106 University Hall Bowling Green State University Bowling Green OH 4340-3-0230 PC Quasiisometries of nilpotent and solvable Lie groups 7,000 00 1011 Veterans Memorial Parkway East Bradley Hospital Providence RI 02915-5061 PC Rhode Island population and genetics study of autism and intellectual disabi 428,129 00 Office of Research Administration, MS 116 415 South St Brandeis University Waltham MA 02454 PC Ambient and intrinsic Diophantine approximation via homogeneous dynami 87,518 00 Office of Research Administration, MS 116 415 South St Brandeis University Waltham MA 02454 PC Critical Phenomena in Random Matrix Theory 7,00000 Office of Research Administration, MS 116 415 South St Brandeis University Waltham MA 02454 PC Critical Phenomena in Random Matrix Theory and Universality 7,00000 Brigham Young University A-285 ASB Campus Drive Brigham Young University Provo UT 84602 PC Computational Number Theory Covering Systems, Probability, and Sieves 7,00000 Brigham Young University A-285 ASB Campus Drive Brigham Young University Provo UT 84602 PC Entropy for Smooth Dynmical Systems 7,000 00 Brigham Young University A-285 ASB Campus Drive Brigham Young University Provo UT 84602 PC Group Boundary Dynamics 7,00000 Brigham Young University A-285 ASB Campus Drive Brigham Young University Provo UT 84602 PC Weakly Holomorphic Modular Forms 7,00000 Brigham Young University A-285 ASB Campus Drive Brigham Young University Provo UT 84602 PC Wild Topology, Attractors and Algebraic invariants 7,00000 415 Main Street Broad Institute, Inc Cambridge MA 02142 PC Accelerating Autism Genetics via Whole Population Ascertainment in Denmz 504,821 00 415 Main Street Broad Institute, Inc Cambridge MA 02142 PC Pieces of the Puzzle Uncovering the Genetics of Autism 374,636 00 415 Main Street Broad Institute, Inc Cambridge MA 02142 PC Role of the 16pll 2 CNV in autism genetic, cognitive and synaptic/circuit an 300,850 00 Office of Sponsored Projects Brown University 164 Angell Street, Box 1929 Brown University Providence RI 02912 PC Linking genetic mosaicism, neural circuit abnormalities and behavior 62,500 00 Office of Sponsored Projects Brown University 164 Angell Street, Box 1929 Brown University Providence RI 02912 PC Research in Arithmetic and Algebraic Dynamics 7,000 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

Office of Sponsored Projects Brown University 164 Angell Street, Box 1929 Brown University Providence RI 02912 PC Simons Foundation Collaborative Travel Grant - S Lichtenbaum 7,000 00 Office of Sponsored Projects Brown University 164 Angell Street, Box 1929 Brown University Providence RI 02912 PC Simons Investigator in Mathematics 66,000 00 Office of Sponsored Projects Brown University 164 Angell Street, Box 1929 Brown University Providence RI 02912 PC Simons Postdoctoral Fellowship 27,547 25 82 University AVe Bucknell University Lewisburg PA 17837 PC Blaschke products Approximation, Interpolation and Geometry 7,000 00 82 University AVe Bucknell University Lewisburg PA 17837 PC Classical groups and their geometries 7,000 00 82 University AVe Bucknell University Lewisburg PA 17837 PC Languages and Geometry of Automorphisms of Groups 7,00000 82 University AVe Bucknell University Lewisburg PA 17837 PC Research Projects in Mathematical Demography and Noncommutative Ring 7,00000 82 University AVe Bucknell University Lewisburg PA 17837 PC Spectral Geometry of Orbifolds 7,00000 82 University AVe Bucknell University Lewisburg PA 17837 PC Symmetric function positivity and the M'bius function of the pattern poset 7,00000 300 Pasteur Dr, H3143 CA - 166/205 - Stanford University Stanford CA 94305-5236 PC Scientific neuroimaging sharing and transparency - Core 548,381 00 300 Pasteur Dr, H3143 CA - 166/205 - Stanford University Stanford CA 94305-5236 PC Simons Fellow in Theoretical Physics 75,000 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC A probiotic therapy for autism 125,00000 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Carving Nature at its Joints Limbic Circuits for Social vs Self-Directed Behavi 240,000 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Direct recording from autism brains 60,074 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Direct recordings from the brain in autism 60,000 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Neural computation of innate defensive behavioral decisions 125,000 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Simons Investigator in Physics 132,000 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Simons Investigator in Physics 66,000 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Understanding visual object coding in the macaque brain 100,000 00 1200 E California Blvd M/C 201-15 California Institute of Technology Pasadena CA 91125 PC Weil-etale Cohomology and Zeta functions of arithmetic schemes 7,00000 1530 P Street, NW Carnegie Institution of Washington Washington DC 20005-1910 PC Potential Protoenzymes Structure and Function of Hyperbranched Polyester 90,000 00 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Hardness of Approximation and Analysis of Boolean Functions 24,000 00 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Mechanism Design Privacy and Incentives for Algorithm Design 24,000 00 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Reliability of Sensory-Evoked Activity in Autism Spectrum Disorders- Project 91,937 00 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Simons Postdoctoral Fellowship 27,547 25 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Unreliability of neuronal responses in mouse models of autism 125,000 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC Advances in predictive mathematical models of brain metabolism 7,000 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC Away from Independence Probability in Geometry and Mathematical Physic 35,345 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC Molecular and Pharmacological Rescue of 16pll Del Phenotype with MAPK/ 250,000 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC Probability and Geometry 7,000 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC Research in Moonshine 7,000 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC The Inverse Problem of Magnetoencephalography A Window of the Brain 121,891 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106-4919 PC Topics in random matrix theory and asymptotic geometric analysis 35,344 00 P O Box 20374 Cell Motion Laboratories, Inc New York NY 10009 PC BioBus + Base Harlem R&D Challenge Grant 1,050,000 00 Office of Research and Sponsored Programs Central Michigan University 251 Foust Hall Central Michigan University Mount Pleasant MI 48859 PC Complex analysis on piecewise-smooth domains 7,00000 Campus de Bellaterra, Edifici C 08193 Bellaterra Centre de Recerca Matemftica Barcelona N/A 08193 NC Simons Visiting Program 55,000 00 300 Longwood Avenue Children's Hospital Boston Boston MA 02115 PC Corticothalamic circuit interactions in autism 100,000 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

300 Longwood Avenue Children's Hospital Boston Boston MA 02115 PC Probing synaptic receptor composition in mouse models of autism 249,994 00 300 Longwood Avenue Children's Hospital Boston Boston MA 02115 PC Role of Microglia and Complement at Developing Synapses in ASD 62,499 50 300 Longwood Avenue Children's Hospital Boston Boston MA 02115 PC Simons Variation in Individuals Project (VIP) Site 328,912 70 4650 Sunset Blvd Children's Hospital Los Angeles Los Angeles CA 90027 PC Functional consequences of disrupted MET signaling 48,509 41 3333 Burnet Avenue Cincinnati Children's Hospital Medical Center - Research Foundation Cincinnati OH 45229 PC Extracellular Signal-Related Kinase Biomarker Development in Autism 54,890 00 150 East Tenth Claremont Graduate University St Claremont CA 91711 PC Analysis of Systems Modelling the Spreading of Surfactant on Thin Films 7,00000 400 N Claremont Boulevard Claremont McKenna College Claremont CA 91711 PC Geometric lattice theory and diophantine problems with heights 7,00000 400 N Claremont Boulevard Claremont McKenna College Claremont CA 91711 PC Sam Nelson Collaboration 7,00000 8 Clarkson Avenue, CU Box 5630 Clarkson University Potsdam NY 13699-5630 PC Collaborative Research on Complex Networks and Complex Systems 7,00000 Office of Sponsored Programs 300 Brackett Hall Clemson University Clemson SC 29634-5702 PC Collaborations between algebraic geometry and computer science 7,000 00 Office of Sponsored Programs 300 Brackett Hall Clemson University Clemson SC 29634-5702 PC Derivatives of Eisenstein Series 7,000 00 Office of Sponsored Programs 300 Brackett Hall Clemson University Clemson SC 29634-5702 PC Dynamics on Panov planes and applications 7,00000 Office of Sponsored Programs 300 Brackett Hall Clemson University Clemson SC 29634-5702 PC Robust Mathematical Approach towards Ocean Modeling 7,000 00 2121 Euclid Avenue, PH220 Cleveland State University Cleveland OH 44115-2214 PC Problems in Topology and Geometry 7,00000 2121 Euclid Avenue, PH220 Cleveland State University Cleveland OH 44115-2214 PC Topological Complexity, Fibrewise Homotopy, Rational Homotopy 7,00000 160 Fifth Avenue, 7th Floor Clinical Research Associates New York, NY 10022 NC Research in autism 1,550,000 00 1919, Route de Mende CNRS Regional Delegation Languedoc-Roussillon Montpellier N/AF-34293 NC Coevolution of RNA and Peptides n Connecting the activation processes 80,000 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC 16pll 2 Defining the gene(s) responsible (grant 1 ) 210,240 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC A novel window into ASD through genetic targeting of striosomes - Project 1 82,473 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Alterations in brain-wide neuroanatomy in autism mouse models 300,000 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Center for Quantitative Biology 1,500,000 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Center for Quantitative Biology Endowment 32,000,000 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Cortical inhibition and disrupted vocal perception in MeCP2 +/- mice 81,970 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Genetic basis of autism 4,000,000 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Interaction of sensory signals and internal dynamics during decision-making 100,000 00 13 Oak Drive Colgate University Hamilton NY 13346-1398 PC The Algebra and Combinatorics of Graph Embeddings 7,00000 66 George Street College of Charleston Charleston SC 29424 PC Collaborative work in conformal field theory 7,00000 College of Staten Island /CUNY Office of Sponsored Programs and Research 2800 Victory Blvd , Bldg 1A-302 College of Staten Island/CUNY jointly with Research Foundation/CUNY Staten Island NY 10314 PC Collaboration Grant for Mathematicians 7,00000 College of Staten Island /CUNY Office of Sponsored Programs and Research 2800 Victory Blvd , Bldg 1A-302 College of Staten Island/CUNY jointly with Research Foundation/CUNY Staten Island NY 10314 PC Collaboration Grants for Mathematicians 7,00000 College of Staten Island /CUNY Office of Sponsored Programs and Research 2800 Victory Blvd , Bldg 1A-302 College of Staten Island/CUNY jointly with Research Foundation/CUNY Staten Island NY 10314 PC Critical point at infinity for some two dimensional problems 7,00000 College of Staten Island /CUNY Office of Sponsored Programs and Research 2800 Victory Blvd , Bldg 1A-302 College of Staten Island/CUNY jointly with Research Foundation/CUNY Staten Island NY 10314 PC Generic properties of geometric groups 7,00000 College of Staten Island /CUNY Office of Sponsored Programs and Research 2800 Victory Blvd , Bldg 1A-302 College of Staten Island/CUNY jointly with Research Foundation/CUNY Staten Island NY 10314 PC Research in Set Theory 7,00000 Box GR 1 College Street College of the Holy Cross Worcester MA 01610-2395 PC Kronecker product of Schur function/Zeta functions of graphs 7,000 00 Grants and Research Administration P O Box 8795 College of William and Mary Williamsburg VA 23187-8795 PC Representation Theory and Combinatorics 7,00000 Grants and Research Administration P O Box 8795 College of William and Mary Williamsburg VA 23187-8795 PC Simons Collaboration on the Many Electron Problem - PI, Monte Carlo Grout 167,000 00 2199 S University Blvd MRB 222 Colorado Seminary, which owns the University of Denver Denver CO 80208 PC Algebraic Proof Theory 7,000 00 2199 S University Blvd MRB 222 Colorado Seminary, which owns the University of Denver Denver CO 80208 PC Computational aspects of loop theory 7,000 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

2199 S University Blvd MRB 222 Colorado Seminary, which owns the University of Denver Denver CO 80208 PC Vertex Algebras, Invariant Theory, and Commutative Algebra 7,000 00 Sponsored Programs Campus Delivery Box 2002 Colorado State University Fort Collins CO 80523-2002 PC Application for Collaboration Grant for Mathematicians 7,000 00 Sponsored Programs Campus Delivery Box 2002 Colorado State University Fort Collins CO 80523-2002 PC Collaboration Grant Algorithms for Groups 7,00000 Sponsored Programs Campus Delivery Box 2002 Colorado State University Fort Collins CO 80523-2002 PC Interactions between number theory and dynamics 7,000 00 Sponsored Programs Campus Delivery Box 2002 Colorado State University Fort Collins CO 80523-2002 PC Multiscale Electrodiffusion in Bulk and on Manifolds 7,00000 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC 2013 Columbia Endowment 1,000,000 00 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC Annual gift to Columbia University for Wendy Chung 750,000 00 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC Higher-Level Olfactory Processing 75,000 00 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC SFARI Undergraduate Summer Research Program 7,79900 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC Simons Society of Fellows - Senior Fellow 30,000 00 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gii 198,617 50 Sponsored Projects Administration Columbia University 630 West 168th Street, Box 49 Columbia University Medical Center New York NY 10032 PC Simons Variation in Individuals Project (VIP) Principal Investigator 263,317 50 226 West Jackson Community College District 508, State of Illinois and County of Cook St Chicago IL 60606 PC Lusternik-Schnirelmann orbifold theory 7,00000 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

373 Pine Tree Road Cornell University Ithaca NY 14850 PC arXiv Operating Grant 350,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Collaboration in Ricci Flow 7,00000 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Combinatorial Group Theory 100,595 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Enumerative Combinatorics of Polytopes, Posets and Coxeter Groups 7,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC lim Only Human Game Theory with Computationally Bounded Agents 24,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Inflation in String Vacua 116,178 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Simons Collaboration on Algorithms and Geometry - PI 80,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Simons Investigator in Computer Science 132,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Spectral Fingerprints of Habitable Planets 139,567.63 373 Pine Tree Road Cornell University Ithaca NY 14850 PC The Geometry of Infinite Discrete Groups 7,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Theoretical Investigations 144,000 00 300 W 12th Street 202 Centennial Hall Curators of the University of Missouri on behalf of Missouri University of Science and Rolla MO 65409-1330 PC Numerical methods and mathematical analysis for interface problems 14,000 00 One University Boulevard Curators of the University of Missouri on Behalf of the University of Missouri - St Louie St Louis MO 63121-4499 PC Algebraic cycles and vector bundles 7,000 00 One University Boulevard Curators of the University of Missouri on Behalf of the University of Missouri - St Louie St Louis MO 63121-4499 PC K3 Surfaces of High Picard Rank 7,000 00 1 East Jackson Boulevard DePaul University Chicago IL 60604-2287 PC Dynamical Systems and the Geometry of Orbits 7,00000 1 East Jackson Boulevard DePaul University Chicago IL 60604-2287 PC Simons Collaboration Grant for Bridget Termer 7,00000 Office of Research Administration 3201 Arch Street, Suite 100 Drexel University Philadelphia PA 19104-2875 PC Collaborative Research in Probability and Combinatorics 7,00000 2200 W Main Street, Suite 710 Duke University Durham NC 27705 PC Chow groups and geometry in dimensions three and four 7,00000 2200 W Main Street, Suite 710 Duke University Durham NC 27705 PC Safety, Efficacy and Basis of Oxytocin and Brain Stimulation Therapy in ASD 114,583 00 2200 W Main Street, Suite 710 Duke University Durham NC 27705 PC Simons Postdoctoral Fellowship 27,547 25 2200 W Main Street, Suite 710 Duke University Durham NC 27705 PC Stochastic dynamics stabilization, ergodicity, and algorithms 7,00000 Suite 820, Erwin Square 2200 West Main Street Duke University Medical Center Durham NC 27705 PC Mapping functional neural circuits that mediate social behaviors in autism 125,000 00 Suite 820, Erwin Square 2200 West Main Street Duke University Medical Center Durham NC 27705 PC Understanding copy number variants associated with autism 250,000 00 P O Box 674 DuplSq Alliance Fayetteville NY 13066 PC Dup15q Alliance and Angelman Syndrome Foundation 2014 Conference 5,00000 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

route de saclay Ecole Polytechnique PALAISEAU N/A 91128 NC Simons Collaboration on the Many Electron Problem - Director, Cluster Emb, 150,000 00 1599 Clifton Road NE, 4th Floor Mailstop 1599-001-1BA Emory University Atlanta GA 30322 PC 5-Hydroxymethylcytosine-mediated gene regulation in autism 200,000 00 1599 Clifton Road NE, 4th Floor Mailstop 1599-001-1BA Emory University Atlanta GA 30322 PC Prenatal folic acid and risk for autism spectrum disorders 252,345 00 Dr Molewaterplein 50 Erasmus Universitair Medisch Centrum Rotterdam Rotterdam, Netherlands 3015 GE NC The role of UBE3A in autism Is there a critical window for social developmer 108,900 00 Boltzmanngasse 9 Erwin Schrodinger International Institute for Mathematical Physics Vienna N/AA-1090 NC Simons Junior Professor in Mathematics or Mathematical Physics 110,000 00 Division of Research, Florida Atlantic University 777 Glades Road Florida Atlantic University Boca Raton FL 33431-0991 PC A degeneration problem for invariant subspaces 7,00000 Division of Research, Florida Atlantic University 777 Glades Road Florida Atlantic University Boca Raton FL 33431-0991 PC Sobolev Inequalities and Isoperimetry 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Algebraic geometry, singularities, and applications to physics 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Fibered 3-manifolds and their monodromy 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Flows and foliations in three manifolds 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Game-theoretic models of animal behavior 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Low Dimensional Topology and Number Theory 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Mathematical Models of Cancer Growth and Treatment 7,00000 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Shape Analysis of Curves and Surfaces 7,000.00 2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC The Birch and Swinnerton-Dyer conjecture and Stark-Heegner points 7,000 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

2000 Levy Avenue, Suite 351 PO Box 3062744 Florida State University Research Foundation, Inc Tallahassee FL 32310-5792 PC Topics in Financial Mathematics 7,00000 Via Morego 30Genova Fondazione Istituto Italiano di Tecnologia 16163 NC Functional connectivity in monogenic mouse models of autism 55,260 00 160 Fifth Avenue, 7th Floor Foundation Associates New York, NY 10022 NC Network of brain tissue collection centers for research activities 1,000,000 00 501 Madison Avenue Friends of IHES New York NY 10022 PC IHES General Operating Support (in Euro) 1,664,839 19 501 Madison Avenue Friends of IHES New York NY 10022 PC Mathematics Mind of the Earth Gala 175,000 00 Av de Brasilia FundaA,,o D Anna de Sommer Champalimaud e Dr Carlos Montez Champalimaud Lisbon, 1400-038 NC Dissecting striatal circuit dynamics during repetitive behaviors in autism 182,254 00 Av de Brasilia FundaA,,o D Anna de Sommer Champalimaud e Dr Carlos Montez Champalimaud Lisbon, 1400-038 NC How the basal ganglia forces cortex to do what it wants - Core 50,510 50 Av de Brasilia FundaA,,o D Anna de Sommer Champalimaud e Dr Carlos Montez Champalimaud Lisbon, 1400-038 NC Neural encoding and decoding of policy uncertainty in the frontal cortex - Cc 122,311 00 3300 Poinsett Highway Furman University Greenville SC 29613 PC Domination, Packing and Structure of Product Graphs 7,000 00 100 N Academy Ave Geisinger Clinic Danville PA 17822 PC identifying the gene in 17q12 responsible for neuropsychiatric phenotypes 140,875 00 100 North Academy Avenue Geisinger Clinic, Weis Center for Research Danville PA 17822-2601 PC Comprehensive phenotypic characterization of the 17q12 deletion syndrom, 62,500 00 100 North Academy Avenue Geisinger Clinic, Weis Center for Research Danville PA 17822-2601 PC Simons Variation in Individuals Project (VIP) Recruitment Core and Phase 2 C 651,289 50 4400 University Drive MSN 4C6 George Mason University Fairfax VA 22030 PC Topology and Algebra of Character Varieties 7,00000 PO Box 8005 Georgia Southern University Rsch & Svc I'd Inc Statesboro GA 30460 PC Combinatorics, Graph Theory and Applications 7,000 00 PO Box 3999 Georgia State University Research Foundation, Inc Atlanta GA 30302-3999 PC Statistical inference based on empirical likelihood 7,000 00 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Application of Zhiwu for Simons fellow 2013-2014 38,538 00 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Asymptotics in Sequence Comparison 7,00000 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Big Data Sets, Information Retrieval under Low-Complexity Constraints 7,00000 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Geometry of Curves and Surfaces 7,00000 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Geometry, Randomness and Free Probability 7,00000 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Mathematical analysis and numerical application of imaging problems 7,00000 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Optimal Alignments, First Passage Percolation and other growth models 7,000.00 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Probabilistic Methods for Sequence Comparison 47,680 00 505 10th Street, NW Georgia Tech Research Corporation Atlanta GA 30332-0420 PC Problems in Univariate and Multivariate Orthogonal Polynomials 7,00000 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

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25 Science Park, 3rd Floor PO Box 208327 Yale University New Haven CT 06520-8327 PC Role of GABA interneurons in a genetic model of autism 187,455 00 25 Science Park, 3rd Floor PO Box 208327 Yale University New Haven CT 06520-8327 PC SFARI Undergraduate Summer Research Program 10,330 00 25 Science Park, 3rd Floor PO Box 208327 Yale University New Haven CT 06520-8327 PC SFARI Undergraduate Summer Research Program 10,33000 25 Science Park, 3rd Floor PO Box 208327 Yale University New Haven CT 06520-8327 PC Simons Investigator in Computer Science 132,000 00 25 Science Park, 3rd Floor PO Box 208327 Yale University New Haven CT 06520-8327 PC Simons Simplex Collection Support Grant 10,000 00 94-20 Guy R Brewer Blvd York College, City University of New York Jamaica NY 11451 PC Wojciechowski_Collaboration_Grant 7,00000 1656 Champlin Avenue Faxton-St Lukes Healthcare Utica NY 13502 PC In Memory Donation 2,500 00 91 South Orange Avenue Newark Academy Livingston NJ 07039 PC In Memory Donation 1,25000 1555 Village Lane Oysterponds Historical Society Inc Orient NY 11957 PC In Memory Donation 2,500 00 45 Lyme Rd Trustees of Dartmouth College Hanover NH 03755-1219 PC In Memory Donation 1,25000 1903 West Michigan Avenue Western Michigan University Kalamazoo MI 49008-5167 PC In Memory Donation 2,50000 814 Goggins Rd Adirondack Mountain Club Lake George NY 12845 PC Employee Matching 700 00 250 Williams Street NW American Cancer Society Altanta AG 30303 PC Employee Matching 200 00 250 Williams Street NW American Cancer Society Altanta AG 30303 PC Employee Matching 100 00 2 Lincoln Square American Folk Art Museum New York NY 10023 PC Employee Matching 120 00 120 Wall Street, 29th FL American Foundation for Suicide Prevention New York NY 10005 PC Employee Matching 100 00 PO Box 37295 American Red Cross Washington DC 20113 PC Employee Matching 500 00 1060 Amsterdam Avenue Amsterdam Nursing Home Corporation New York NY 100025 PC Employee Matching 200 00 1330 West Peachtree St NW, Suite 100 Arthritis Foundation Atlanta GA 30309 PC Employee Matching 200 00 5048 N Jackson Ave Autism Science Center Fresno CA 93740 PC Employee Matching 515 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

5048 N Jackson Ave Autism Science Center Fresno CA 93740 PC Employee Matching 206 00 PO Box 5000 Bard College Annandale on Hudson NY 12504-5000 PC Employee Matching 2,00000 3009 Broadway Barnard College New York NY 10027 PC Employee Matching 600 00 PO Box 79203 Biggies Bullies Pittsburgh PA 79203 PC Employee Matching 200 00 60 East 56th Street, 8th Floor Breast Cancer Research Foundation Inc New York NY 10022 PC Employee Matching 500 00 95 Commercial Street, Suite 2 Brooklyn Rail Inc Brooklyn NY 11222 PC Employee Matching 1,40000 1100-2200 Yonge St Canadian Unicef Committee Toronto Ontario NC Employee Matching 170 00 1047 Amsterdam Avenue Cathedral Church of St John the Divine New York NY 10025 PC Employee Matching 200 00 445 Park Avenue Child Mind Institute New York NY 10022 PC Employee Matching 400.00 27 South La Patera LaneSanta Direct Relief Barbara CA 93117 PC Employee Matching 400 00 One World Aveue Heifer Project International Little Rock AR 72201 PC Employee Matching 2,00000 1101 E 58th Street Rosenwald Hall 105 IL - 155/279 - University of Chicago Chicago IL 60637 PC Employee Matching 400 00 Westchester County Chapter JDRF New York NY 10603 PC Employee Matching 200 00 1600 Constance Street Kingsley House New Orleans LA 70130 PC Employee Matching 200 00 500 Broad Avenue Leonia Middle School Home & School Association Leonia NJ 07605 PC Employee Matching 140 00 PO Box 212 Leonia Sports Boosters Leonia NJ 07605 PC Employee Matching 1,50000 PO Box 116 Lions Club of Leonia Charitable Foundation Inc Leonia NJ 07605 PC Employee Matching 100 00 100 Forest Drive Lymphatic Research Foundation East Hills NY 11548 PC Employee Matching 100 00 Biology Finance Office, Attn Alison Salie Massachusetts Institute of Technology Cambridge MA 02139 PC Employee Matching 5,00000 1275 York Avenue Memorial Sloan-Kettering Cancer Center New York NY 10065 PC Employee Matching 200 00 45 SW Ankeny St Mercy Corps Portland OR 97204 PC Employee Matching 240 00 2401 Virginia Ave NW Miriam's Kitchen Washington DC 20037 PC Employee Matching 800 00 PO Box 1595 Movember Inc Culver City CA 90232 PC Employee Matching 100.00 40 Rector Street, 5th Floor I NAACP Legal Defense and Educational Fund Inc New York NY 10006 PC Employee Matching 200 00 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

1145 17th Street, NW Development Office National Geographic Society Washington, DC 20036 PC Employee Matching 200 00 1205 N Rampart St New Orleans Jazz & Heritage Foundation, Inc New Orleans LA 70116 PC Employee Matching 500 00 16 Lewyt Street North Shore Animal League America Inc Port Washington NY 11050 PC Employee Matching 400 00 490 Riverside Drive, 11th FL Orpheus Chamber Orhcestra New York NY 10027 PC Employee Matching 300 00 226 Causeway Street Oxfam America Boston MA 2114 PC Employee Matching 500 00 2560 Ninth St , Suite 315 B Partners Asia (formerly) Community Partners International Berkeley CA 94710 PC Employee Matching 1,000 00 434 W 33rd Street Planned Parenthood Federation of America New York NY 10001 PC Employee Matching 1,00000 434 W 33rd Street Planned Parenthood Federation of America New York NY 10001 PC Employee Matching 200 00 9216 Seventh Avenue Poly Prep Country Day School Brooklyn NY 11228 PC Employee Matching 2,00000 200 Lake Street Progeria Research Foundation Inc Peabody MA 01960 PC Employee Matching 200 00 801 Riverside Drive, #6G Project ALS Inc New York NY 10032 PC Employee Matching 2,00000 281 Ninth Ave PS033M Chelsea Prep PTA Inc New York NY 10001 PC Employee Matching 800 00 100 Mission Drive Red Cloud Indian School Pine Ridge SD 57770 PC Employee Matching 2,00000 Attn Dana Gulley 20 Secor Road Riverkeeper Ossining NY 10562 PC Employee Matching 200 00 826 Broadway, 9th Floor Robin Hood New York NY 10003 PC Employee Matching 500 00 826 Broadway, 9th Floor Robin Hood New York NY 10003 PC Employee Matching 200 00 405 East 73rd Street Ronald McDonald House of New York New York NY 10021 PC Employee Matching 100 00 116 Kraft Rotary Club of Bronxville Foundation Bronxville NY 10708 PC Employee Matching 100 00 P 0 Box 147H Scarsdale High School PTA Scholarship Fund for College Scarsdale NY 10583 PC Employee Matching 400 00 295 St Ann's Ave St Ann's Church of Morrisania Bronx NY 10454 PC Employee Matching 200 00 1333 S Mayflower Avenue Suite 400 St Baldrick's Foundation Monrovia CA 91016 PC Employee Matching 700 00 501 St Jude Place St Jude Children's Research Hospital Memphis TN 38105 PC Employee Matching 1,00000 900 South Crouse Ave Syracuse University Syracuse NY 13244 PC Employee Matching 200.00 6402 Arlington Blvd , Suite 300 Tahirih Justice Center Falls Church VA 22042 PC Employee Matching 400 00 901 S Mopac Expressway Texas 4000 for Cancer Austin TX 78746 PC Employee Matching 2,50000 THE SIMONS FOUNDATION, INC 2014 FORM 990-PF STATEMENT 15 13-3794889 PART XV, LINE 3A SCHEDULE OF GRANTS PAID

27001 Agoura Rd #350 The Amyotrophic Lateral Sclerosis Assocation Calabasas Hills CA 91301 PC Employee Matching 100 00 168 Park Ave The Community Chest of Leonia, N J Leonia NJ 07605-2012 PC Employee Matching 200 00 PO Box 395 The Corporation of Yaddo Saratoga Springs NY 12866 PC Employee Matching 200 00 511 Warburton Avenue The Hudson River Museum of Westchester Yonkers NY 10701 PC Employee Matching 200 00 408 Fontaine PI The Leukemia and Lymphoma Society Ridgeland MS 39157 NC Employee Matching 300 00 42-40 Bell Boulevard Tourette Syndrome Association Inc Bayside NY 11361 PC Employee Matching 100 00 45 Lyme Rd Trustees of Dartmouth College Hanover NH 03755-1219 PC Employee Matching 800 00 2080 Addison Street #4200 University of California Berkeley Foundation Berkeley CA 94720-4200 PC Employee Matching 8,000 00 161 Sky Meadow Drive Villa Maria School Stamford CT 06903 PC Employee Matching 600.00 One Brookings Drive Washington University in St Louis St Louis MO 63130-4899 PC Employee Matching 3,00000 86 Main Street Yonkers Partners in Education Yonkers NY 10701 PC Employee Matching 1,00000 460 W 34th St Young Adult Institute, Inc New York NY 10001 PC Employee Matching 500 00 PO Box 206950 Youth Rights Media New haven CT 06520 PC Employee Matching 200 00

Total Grants Paid 232 ,372,215 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

2014 Grant Payable

Recipient Name Recipient Address Status Purpose of Grant Amount Payable Office of Research Services 3451 Walnut Street Room P 221 15/221 University of Pennsylvania Philadelphia PA 19104 PC Simons Investigator in Physics 660,000 00 2950 Hobson Way Air Force Institute of Technology WPAFB OH 45433 PC Overturned Traveling Waves 28,000 00 P 0 Box 2260 Arizona State University Foundation Tempe AZ 85280 2260 PC Complex hyperbolic discrete groups and lattices 28,000 00 2000 University Avenue Ball State University Muncie IN 47306 PC Collaboration Grant n Complex Dynamics 28,000 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC Catching fireflies Dynamic neural computations for foraging 500,000 00 One Baylor Plaza MS BCM 310 Baylor College of Medicine Houston TX 77030 PC Simons Simplex Collection Support Grant 20,000 00 151 Whittier Research Center 2200 Vine Street Board of Regents of the University of Nebraska University of Nebraska Lincoln Lincoln NE 68583 0861 PC Operator Algebras and Extensions of Inverse Semigroups 28,000 00 151 Whittier Research Center 2200 Vine Street Board of Regents of the University of Nebraska University of Nebraska Lincoln Lincoln NE 68583 0861 PC Singularity categories K theory and A infinity algebras 28,000 00 1 University Circle Board of Trustees of Western Illinois University Macomb IL 61455 PC Valued o minimal fields measures and residue field domination 28,000 00 5800 College Station Bowdoin College Brunswick ME 04530 PC Geometry and quasi isometry classification of some self similar groups 28,000 00 106 University Hall Bowling Green State University Bowling Green OH 4340 3 0230 PC Quasusometries of nilpotent and solvable Lie groups 28,000 00 Brigham Young University A 285 ASB Campus Drive Brigham Young University Provo UT 84602 PC Computational Number Theory Covering Systems Probability and Sieves 28,00000 415 Main Street Broad Institute Inc Cam bridge MA 02142 PC Pieces of the Puzzle Uncovering the Genetics of Autism 374,63600 Office of Sponsored Projects Brown University 164 Angell Street Box 1929 Brown University Providence RI 02912 PC Simons Investigator in Mathematics 594,000 00 82 University Ave Bucknell University Lewisburg PA 17837 PC Languages and Geometry of Automorphisms of Groups 28,00000 1200 E California Blvd M/C201 15 California Institute of Technology Pasadena CA 91125 PC A probiotic therapyfor autism 625,00000 1200 E California Blvd M/C201 15 California Institute of Technology Pasadena CA 91125 PC Direct recordings from the brain in autism 60,000 00 1200 E California Blvd M/C201 15 California Institute of Technology Pasadena CA 91125 PC Neural computation of innate defensive behavioral decisions 625,000 00 1200 E California Blvd M/C201 15 California Institute of Technology Pasadena CA 91125 PC Understanding visual object coding in the macaque brain 500,000 00 1530 P Street NW Carnegie Institution of Washington Washington DC 20005 1910 PC Potential Protoenzymes Structure and Function of Hyperbranched Polyesters 85,640 00 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Hardness of Approximation and Analysis of Boolean Functions 24,000 00 5000 Forbes Ave WQED Bldg Carnegie Mellon University Pittsburgh PA 15213 PC Mechanism Design Privacyand Incentives for Algorithm Design 24,000 00 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106 4919 PC Probability and Geometry 28,000 00 10900 Euclid Avenue Case Western Reserve University Cleveland OH 44106 4919 PC Research in Moonshine 28,000 00 P O Box 20374 Cell Motion Laboratories Inc New York NY 10009 PC BioBus + Base Harlem R&D Challenge Grant 1,000,000 00 Office of Research and Sponsored Programs Central Michigan University 251 Foust Hall Central Michigan University Mount Pleasant Al 48859 PC Complex analysis on piecewise smooth domains 28,000 00 Campus de Bellaterra Edifici C 08193 Bellaterra Centre de Recerca Matemttca Barcelona N/A 08193 NC Simons Visiting Program 110,000 00 300 Longwood Avenue Children s Hospital Boston Boston MA 02115 PC Simons Variation in Individuals Project (VIP) Site 245,108 11 400 N Claremont Boulevard Claremont McKenna College Claremont CA91711 PC Sam Nelson Collaboration 28,000 00 8 Clarkson Avenue CU Box 5630 Clarkson University Potsdam NY 13699 5630 PC Collaborative Research on Complex Networks and Complex Systems 28,000 00 Office of Sponsored Programs 300 Brackett Hall Clemson University Clemson SC 29634 5702 PC Dynamics on Panov planes and applications 28,000 00 Office of Sponsored Programs 300 Brackett Hall Clemson University Clemson SC 29634 5702 PC Robust Mathematical Approach towards Ocean Modeling 28,000 00 1919 Route de Mende CNRS Regional Delegation Languedoc Roussillon Montpellier N/AF 34293 NC Convolution of RNA and Peptides n Connecting the activation processes 80,000 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC A novel window into ASD through genetic targeting of striosomes Project 1 149,718 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Genetic basis of autism 7,186,130 00 1 Bungtown Road Cold Spring Harbor Laboratory Cold Spring Harbor NY 11724 PC Interaction of sensorysignals and internal dynamics during decision making 500,00000 13 Oak Drive Colgate University Hamilton NY 13346 1398 PC The Algebra and Combinatorics of Graph Embeddings 28,000 00 66 George Street College of Charleston Charleston SC 29424 PC Collaborative work in conformal field theory 28,000 00 Grants and Research Administration P O Box 8795 College of W illiam and Mary Williamsburg VA 23187 8795 PC Simons Collaboration on the Many Electron Problem PI Monte Carlo Group 668,000 00 2199 S University Blvd MRB 222 Colorado Seminary which owns the University of Denver Denver CO 80208 PC Vertex Algebras Invariant Theory and Commutative Algebra 28,000 00 Sponsored Programs Campus Delivery Box2002 Colorado State University Fort Collins CO 8OS23 2002 PC Application for Collaboration Grant for Mathematicians 28,00000 Sponsored Projects Administration Columbia University 630 West 168th Street Box 49 Columbia University Medical Center New York NY 10032 PC Annual gift to Columbia University for Wendy Chung 6,750,00000 Sponsored Projects Administration Columbia University 630 West 168th Street Box 49 Columbia University Medical Center New York NY 10032 PC Higher Level Olfactory Processing 675,000 00 Sponsored Projects Administration Columbia University 630 West 168th Street Box 49 Columbia University Medical Center New York NY 10032 PC Simons Variation in Individuals Project (Simons VIP) Principal Investigator Gift 104,266 50 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

373 Pine Tree Road Cornell University Ithaca NY 14850 PC hm Only Human Game Theorywith Computationally Bounded Agents 24,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC Simons Collaboration on Algorithms and Geometry PI 240,000 00 373 Pine Tree Road Cornell University Ithaca NY 14850 PC The Geometry of Infinite Discrete Groups 28,000 00 300 W 12th Street 202 Centennial Hall Cu rators of the University of Missouri on behalf of Missouri University of Science and Technology Rolla MO 654091330 PC Numerical methods and mathematical analysis for interface problems 28,00000 2200 W Main Street Suite 710 Duke University Durham NC 27705 PC Safety Efficacy and Basis of Oxytocin and Brain Stimulation Therapy in ASD 572,915 00 Suite 820 Erwin Square 2200 West Main Street Duke University Medical Center Durham NC 27705 PC Mapping functional neural circuits that mediate social behaviors in autism 62,500 00 route de saclay Ecole Polytechnique PALAISEAU N/A 91128 NC Simons Collaboration on the Many Electron Problem Director Cluster Embedding Group 600,000 00 Or Molewaterplein 50 Erasmus Universitair Med isch Cen trum Rotterdam Rotterdam Netherlands 3015 GE NC Environment wide association study of autism 250,000 00 Boltzmanngasse 9 Erwin Schrod anger International Institute for Mathematical Physics Vienna N/AA 1090 NC Simons Junior Professor in Mathematics or Mathematical Physics 440,000 00 2000 Levy Avenue Suite 351 PO Box 3062744 Florida State University Research Foundation Inc Tallahassee FL 32310 5792 PC Shape Analysis of Curves and Surfaces 28,000 00 2000 Levy Avenue Suite 351 PO Box 3062744 Florida State University Research Foundation Inc Tallahassee FL 32310 5792 PC Topics in Financial Mathematics 28,000 00 Av de Brasilia FundaA o D Anna de Sommer Champalimaud e Or Carlos Montez Champalimaud Lisbon 1400 038 NC Dissecting striatal circuit dynamics during repetitive behaviors in autism 107,254 00 Av de Brasilia FundaA o D Anna de Sommer Champalimaud e Dr Carlos Montez Champalimaud Lisbon 1400 038 NC How the basal ganglia forces cortex to do what it wants Core 237,584 50 Av de Brasilia FundaA o D Anna de Sommer Champalimaud e Or Carlos Montez Champalimaud Lisbon 1400 038 NC Neural encoding and decoding of policy uncertainty in the frontal cortex Core 411,974 00 100 North Academy Avenue Geisinger Clinic Weis Center for Research Danville PA 17822 2601 PC Simons Variation in Individuals Project (VIP) Recruitment Core and Phase 2 Coordination Si 436,236 75 PO Box 3999 Georgia State University Research Foundation Inc Atlanta GA 30302 3999 PC Statistical inference based on empirical likelihood 28,000 00 50510th Street NW Georgia Tech Research Corporation Atlanta GA 30332 0420 PC Big Data Sets Information Retrieval under Low Complexity Constraints 28,000 00 50510th Street NW Georgia Tech Research Corporation Atlanta GA 30332 0420 PC Geometry Randomness and Free Probability 28,000 00 50510th Street NW Georgia Tech Research Corporation Atlanta GA 30332 0420 PC Optimal Alignments First Passage Percolation and other growth models 28,000 00 25 Shattuck Street Suite 509A Harvard Medical School Boston MA 02115 PC Decoding internal state to predict behavior 500,000 00 25 Shattuck Street Suite 509A Harvard Medical School Boston MA 02115 PC Optical imaging of circuit dynamics in autism models in virtual reality 165,691 00 301 Platt Blvd Harvey Mudd College Claremont CA91711 PC Discrete & Continuous Models of Non local Chemical and Biological Systems 28,000 00 370 Lancaster Ave Haverford College Haverford PA 19041 PC p adic Representations Affine Flag Varieties and Alcove Walks 28,000 00 20 Squadron Blvd Suite 630 Helen Hay Whitney Foundation New City NY 10956 PC Simons Whitney Fellows 1,464,000 00 19700 Helix Drive Howard Hughes Medical Institute Ja nelia Farm Research Campus Ashburn VA 20147 PC Dynamics of neural circuits representation of information and behavior 300,000 00 19700 Helix Drive Howard Hughes Medical Institute Janelia Farm Research Campus Ashburn VA 20147 PC Neural implementation of internal models of the environment 200,000 00 1 19700 Helix Drive Howard Hughes Medical Institute Ja nelia Farm Research Campus Ashburn VA 20147 PC Understanding neural computations across the global brain 300,0. THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

707 N Broadway Hugo W Moser Research Institute at Kennedy Krieger Inc Baltimore MD 21205 PC Interactive Autism Network Core and Simons Simplex Collection Registry 146,448 00 IFT UNESP (1f andar) Rua Dr Bento Teobaldo Ferran 271 Bloco 2 Barra Funda ICTP South American Institute for Fundamental Research S o Paulo 01140 070 NC Sao Paulo State Research Funding Agency Fellowship 240,000 00 Dr Bohr Gasse 7 IMP Research Institute of Molecular Pathology GmbH Vienna 1030 NC Dense Mapping of Dynamics onto Structure in the C elegans Brain 243,919 80 101 rue de Institut National de la SantE et de la Recherche MEdica le Tolbiacpa ris 75013 NC How the basal ganglia forces cortex to do what it wants Project 1 262,404 50 Einstein Drive Institute for Advanced Study Princeton NJ 08540 0631 PC Acquisition Storage and Inheritance of Information in Dynamical Living Matte 591,250 44 Einstein Drive Institute for Advanced Study Princeton NJ 08540 0631 PC Acquisition Storage and Inheritance of Information in Dynamical Living Matte 473,000 44 Einstein Drive Institute for Advanced Study Princeton NJ 08540 0631 PC Institute for Advanced Study IAS)/Rockefeller University Joint Initiative in Qualitative Biolo 2 ,060,000 00 Einstein Drive Institute for Advanced Study Princeton NJ 08540 0631 PC Simons Collaboration on Algorithms and Geometry PI 240,000 00 Iowa State University 1750 Beardshear Hall Iowa State University College of Liberal Arts and Sciences Ames IA 50010 PC Computability with Continuous Data 28,000 00 1138 Pearson Hall Iowa State University of Science and Technology Ames IA 50011 2207 PC Many Server Queueing Networks in Heavy Traffic 28,000 00 20 Clarkson Road Isaac Newton Institute for Mathematical Sciences Cambridge CB3 OEH NC Simons Fellowship Program 600,000 00 Johns Hopkins University Central Lockbox Bank of America 12529 Collections Center Drive Johns Hopkins University Chicago IL 60693 PC Simons Investigator in Physics 594,000 00 Johns Hopkins University SOM 733 North Broadway Suite 117 Broadway Research Building Johns Hopkins University School of Medicine Baltimore MD 21205 PC Understanding brain disorders related to the 15g11 2 chromosomal region 625,000 00 2 Fairchild Hall Kansas State University Manhattan KS 66506 1103 PC New models of fracture in solids with curvature dependent surface tension 28,000 00 2 Fairchild Hall Kansas State University Manhattan KS 56S06 1103 PC Simons Collaboration Grant Kerr 2014 28,00000 The Strand Kings College London London WC2R 2LS NC Simons Collaboration on the Many Electron Problem Director Real Materials Group 1,200,000 00 The Strand Kings College London London WC2R 2LS NC Simons Collaboration on the Many Electron Problem PI Real Materials Group 600,000 00 Office of Research and Sponsored Programs 526 Brodhead Avenue Lehigh University Bethlehem PA 18015 PC Degeneration of Kahler Einstein Metrics 28,000 00 3520 San Martin Drive rm 333 Life Sciences Research Foundation Baltimore MD 21218 PC Life Sciences Research Foundation Fellowships 915,000 00 Office of Research Services 1032 W Sheridan Road Granada Center Suite 400 Loyola University Chicago ChicagolL60660 1537 PC Set Valued and Convex Analysis in Dynamics and Control 28,000 00 Geschwister Scholl Platz 1 Ludwig Maximilians Unrversitaet Munich 80539 NC Nonequilibrium Mechanisms for the Biogenesis of Life 1 ,356,500 00 Research Management 101 Huntington Ave Suite 300 Massachusetts General Hospital The General Hospital Corp Boston MA 02199 PC Molecular consequences of strong effect ASD mutations including 16p11 2 625,000 00 77 Massachusetts Avenue Massachusetts Institute of Technology Cambridge MA 02139 4307 PC A novel window into ASD through genetic targeting of striosomes Core 434,045 50 77 Massachusetts Avenue Massachusetts Institute of Technology Cambridge MA 02139 4307 PC Characterizing sensory hypersensitivities in autism 676,810 00 1 77 Massachusetts Avenue Massachusetts Institute of Technology Cambridge MA 02139 4307 PC Christos Tzamos Simons Award Application 24,000 00 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

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Office of Sponsored Programs 1111 Spring Garden Street 2702 MHRA Building The University of North Carolina at Greensboro Greensboro NC 27412 5013 PC Analysis of nonlinear eigenvalue problems and applications 28,000 00 Office of Sponsored Projects The University of Texas at Austin 101 East 27th Street Suite 5 300 The University of Texas at Austin Austin TX 78712 1532 PC Neural coding and dynamics for short term memory 540,000 00 8000 York Road Towson University Towson MD 21252 PC Multivariate Polynomial Splines 28,000 00 881 Commonwealth Avenue Trustees of Boston University Boston MA 02215 PC Equivariant Topological Field Theories in Singularity and K Theories 28,000 00 881 Commonwealth Avenue Trustees of Boston University Boston MA 02215 PC Simons Investigator in the Mathematical Modeling of Living Systems 330,000 00 881 Commonwealth Avenue Trustees of Boston University Boston MA 02215 PC Simons Investigator in the Mathematical Modeling of Living Systems 264,000 00 881 Commonwealth Avenue Trustees of Boston University Boston MA 02215 PC The neural substrates of memories and decisions Project 1 226,536 00 Sponsored Projects Administration 615 West 131 St Room 254 Mail Code 8725 Trustees of Columbia University in the City of New York Morningside New York NY 10027 PC Simons Foundation Award for Theoretical Computer Science 24,000 00 Sponsored Projects Administration 615 West 131 St Room 254 Mail Code 8725 Trustees of Columbia University in the City of New York Morningside New York NY 10027 PC Simons Society of Fellows Senior Fellow 30,00000 Sponsored Projects Administration 615 West 131 St Room 254 Mail Code 8725 Trustees of Columbia University in the City of New York Morningside New York NY 10027 PC Simons TCS fellowship 24,00000 Sponsored Projects Administration 615 West 131 St Room 254 Mail Code 8725 Trustees of Columbia University in the City of New York Morningside New York NY 10027 PC The Log Concavity Conjecture for Genus Polynomials of Graphs 28,00000 Sponsored Projects Administration 615 West 131 St Room 254 Mail Code 8725 Trustees of Columbia University in the City of New York Morningside New York NY 10027 PC Trace Formulae L functions and Analytic Number Theory 28,00000 11 Rope Ferry Road #6210 Trustees of Dartmouth College Hanover NH 03755 1404 PC Problems in Inverse Spectral Geometry 28,000 00 11 Rope Ferry Road #6210 Trustees of Dartmouth College Hanover NH 03755 1404 PC Simons Investigator in the Mathematical Modeling of Living Systems 330,000 00 11 Rope Ferry Road #6210 Trustees of Dartmouth College Hanover NH 03755 1404 PC Simons Investigator in the Mathematical Modeling of Living Systems 264,000 00 840S Wood St Suite S 18 E CSB Dept of Surgery M/C 958 UIC Chicago IL 60612 PC Simons Simplex Collection Support Grant 20,00000 Research Services University College London Gower Street University College London London WC1E 6BT NC Global brain states and local cortical processing 485,11850 Research Services University College London Gower Street University College London London WC1E 6BT NC Systems Chemistry Investigating the Chemical Origins of Life 899,994 16 Research Services University College London Gower Street University College London London WC1E 6BT NC The latent dynamical structure of mental activity 502,770 50 210 Administration Building University of Arkansas Fayetteville AR 72701 PC Geometric Aspects of Infinite Groups 28,000 00 51 Goodman Drive P O Box 210222 University of Cincinnati Cinnn nati OH 45221 0222 PC Bellman functions Mange Ampere equations and sharp integral estimates 28,000 00 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

51 Goodman Drive P O Box 210222 University of Cincinnati Cincinnati OH 45221 0222 PC Statistical Methods for Distributed Massive Spatial/Spatio temporal Data 28,000 00 Grants and Contracts Mail Stop F428 Ansch utz Medical Campus Building 500 13001 E 17th Place Rm W1126 University of Colorado Denver AMC and DC Aurora CO 80045 PC Collaboration in Computational Combinator ics 28,000 00 Grants and Contracts Mail Stop F428 Ansch utz Medical Campus Building 500 13001 E 17th Place Rm W1126 University of Colorado Denver AMC and DC Aurora CO 80045 PC Dosage effects of DUF1220 gene subtype CON1 in autism 187,500 00 Grants and Contracts Mail Stop F428 Ansch utz Medical Campus Building 500 13001 E 17th Place Rm W1126 University of Colorado Denver AMC and DC Aurora CO 80045 PC Graph Theory Problems Related to Measuring Closeness to Planarity 28,00000 438 Whitney Road Ext Unit 1133 University of Connecticut Storrs CT 06269 1133 PC Topics on Hyperbolic Kac Moody Algebras and Groups 28,00000 219 Granter Hall University of Florida Gainesville FL 32611 PC Analytic Combinatorial and Computational Study of Partitions 28,000 00 219 Granter Hall University of Florida Gainesville FL 32611 PC Iterated Function Systems 28,000 00 219 Granter Hall University of Florida Gainesville FL 32611 PC Problems in Number Theory and Combinatorics related to q series 28,000 00 24 rue General Dufour University of Geneva Geneva 1204 NC Neural encoding and decoding of policy uncertainty in the frontal cortex Project 1 273,24000 2440 Campus Road Box 368 University of Hawaii Honolulu HI 96822 PC Automatic complexity 28,000 00 2440 Ca mpus Road Box 368 University of Hawaii Honolulu HI 96822 PC Simons Collaboration on Ocean Processes and Ecology 36,000,000 00 Youngberg Hall 2385 Irving Hill Road University of Kansas Center for Research Inc Lawrence KS 66045 PC Recent Progress on Gromov Witten and Donaldson Thomas theory 28,000 00 500 South Limestone 109 Kinkead Hall University of Kentucky Research Foundation Lexington KY 40526 0001 PC Collaborations in Commutative Algebra 28,000 00 5717 Corbett Hall University of Maine University of Maine System acting through the University of Maine Orono ME 04469 5717 PC Automorphic forms and the trace formula 28,000 00 3112 Lee Building 7809 Regents Drive University of Maryland College Park College Park MD 20742 5141 PC Topics in harmonic analysis 28,000 00 70 Butterfield Terrace Research Admin itration Building University of Massachusetts Amherst Amherst MA 01003 PC Geometry and topology of smooth four manifolds 28,00000 70 Butterfield Terrace Research Admin it ration Building University of Massachusetts Amherst Amherst MA 01003 PC Holomorphic curves and contact geometry 28,00000 70 Butterfield Terrace Research Admin itration Building University of Massachusetts Amherst Amherst MA 01003 PC Simons Collaboration on the Many Electron Problem PI Monte Carlo Group 668,000 00 1320 S Dixie Highway suite 650 University of Miami Coral Gables FL 33146 2403 PC Rational Catalan Combinator ics 28,000 00 Office of Sponsored Programs Admin 115 Business Loop 70W Mizzou North Room 501 University of Missouri Columbia Columbia MO 65211 PC Problems in Fourier Analysis 28,00000 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

Office of Sponsored Programs Admin 115 Business Loop 70W Mizzou North Room 501 University of Missouri Columbia Columbia MO 65211 PC Randomized isoperimetric inequalities and concentration phenomena 28,00000 940 Grace Hall University of Notre Dame Notre Dame IN 46556 5612 PC Collaborations on Hilbert functions and related topics 28,000 00 940 Grace Hall University of Notre Dame Notre Dame IN 46556 5612 PC Computability and Definability 28,000 00 940 Grace Hall University of Notre Dame Notre Dame IN 46556 5612 PC Symplectic embeddings and isotopies 28,000 00 Sponsored Projects Services 5219 University of Oregon University of Oregon Eugene OR 97403 S219 PC Random matrices and polynomials with logarithmic weights 28,00000 University Offices Wellington Square University of Oxford Oxford OX1 2JD NC Validation of a diffusion imaging biomarker of autism 189,523 LO_ Office of Research University Club 123 University Place University of Pittsburgh Pittsburgh PA 15213 PC Attentional modulation of neuronal variability constrains circuit models 500,00000 518 Hylan Bldg Box270140 University of Rochester Rochester NY 14627 0140 PC p adic analysis in families of exponential sums 28,000 00 Research 307 University Blvd AD200 University of South Alabama Mobile AL 36688 PC Diagrammatics and higher dimensional knottings 28,000 00 1600 Hampton Street Suite 414 University of South Carolina USC Columbia SC 29208 0001 PC Group actions derived categories birational geometry and mirror symmetry 28,000 00 3702 Spectrum Blvd Suite 165 University of South Florida Tampa FL 33612 PC Algorithmic Questions of Self Similar and L presented group 28,000 00 3702 Spectrum Blvd Suite 165 University of South Florida Tampa FL 33612 PC Two Dimensional Coulomb Gas and Random Matrices 28,000 00 1201 W University Drive University of Texas Rio Grande Valley Edinburg TX 78539 2909 PC Closed and approximate solutions to equations on wave propagation phenomena 28,000 00 Office of Sponsored Programs 4333 Brooklyn Ave NE Box 359472 University of Washington Seattle WA 98195 PC Autism subtypes by gene characterization 318,82400 Office of Sponsored Programs 4333 Brooklyn Ave NE Box 359472 University of Washington Seattle WA 98195 PC Genetic basis of phenotypic variability in 16p112 deletion or duplication 285,85600 Office of Sponsored Programs 4333 Brooklyn Ave NE Box 359472 University of Washington Seattle WA 98195 PC Simons Fellowship Application 24,00000 Office of Sponsored Programs 4333 Brooklyn Ave NE Box 359472 University of Washington Seattle WA 98195 PC Simons Simplex Collection Support Grant 20,00000 Office of Sponsored Programs 4333 Brooklyn Ave NE Box 359472 University of Washington Seattle WA 98195 PC Simons Variation in Individuals Project (VIP) Site 275,598 75 Office of Sponsored Programs UWM Office of Research P 0 Box 340 University of Wisconsin Milwaukee Milwaukee WI 53201 PC Lie Superalgebras and Enveloping Algebras 28,00000 Office of Sponsored Programs UWM Office of Research P 0 Box 340 University of Wisconsin Milwaukee Milwaukee WI 53201 PC Relatively hyperbolic groups and cube complexes 28,00000 1 712 Broadway St University of Wisconsin Stout Menomonie WI 54751 PC Cohomology of finite groups of Lie type and algebraic groups 28,000 00 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

Dept 3355 1000 E University Avenue University of Wyoming Laramie WY 82071 PC Some problems in the classification of C' algebras 28,000 00 R%,mistrasse 71 University of Zurich Zurich 8006 NC Probing recurrent dynamics in prefrontal cortex 500,13750 Department of Contracts and Grants 3720 S Flower Street USC/University of Southern California Los Angeles CA 90089 PC Simons Investigator in Computer Science 594,000 00 Office of Sponsored Programs 1400 18th Avenue South Vanderbilt University Medical Center Nashville TN 37212 PC Immune p38 alpha MAPK activation Convergent mechanism linking autism models 534,627 50 Office of Sponsored Programs 1400 18th Avenue South Vanderbilt University Medical Center Nashville TN 37212 PC Simons Simplex Collection Support Grant 20,000 00 124 Raymond Avenue Box 657 Vassar College Poughkeepsie NY 12604 PC Topics in Operator Algebras Perturbations Dynamics and Bimodules 28,000 00 Office of Research Sponsored Programs PO BOX 980568 Virginia Commonwealth University Richmond VA 23298 0568 PC Forcing and the nonstationary ideal 28,000 00 Room 423 Neill Hall Washington State University Pullman WA 99164 3140 PC Analysis of infectious diseases and eradication of an in vasive species 28,000 00 Room 423 Neill Hall Washington State University Pullman WA 99164 3140 PC Modeling wellposedness and control for swimming phenomenon 28,00000 Campus Box 1054 One Brookings Drive Washington University in St Louis St Louis MO 631304862 PC Foliations flows and contact structures 28,000 00 5057 Woodward Ste 13202 Wayne State University Detroit MI 48202 PC Algebraic Topology Manifolds and Statistical Mechanics 28,000 00 6100 S Main MS 16 William Marsh Rice University Houston TX 77005 1892 PC Combinatorial and Diophantine Properties of Dynamical Systems 28,000 00 6100 S Main MS 16 William Marsh Rice University Houston TX 77005 1892 PC Simons Chair in Mathematics and Geoscience at Rice University 1,530,000 00 100 Institute Road Worcester Polytechnic Institute Worcester MA 01609 PC Linkages and other geometric constraint systems 28,00000 25 Science Park 3rd Floor PO Box 208327 Yale University New Haven CT 06520 8327 PC Disrupted Network Activity in Neonatal Cortex of Mouse Models of Autism 187,500 00 25 Science Park 3rd Floor PO Box 208327 Yale University New Haven CT 06520 8327 PC Network properties and plasticity in high and low gain cortical states Project 1 200,000 00 25 Science Park 3rd Floor PO Box 208327 Yale University New Haven CT 06520 8327 PC Simons Simplex Collection Support Grant 20,000 00 94 20 Guy R Brewer Blvd York College City University of New York Jamaica NY 11451 PC Wojciechowski_Collaboration_Grant 28,000 00 125 Broad Street 18th Floor American Civil Liberties Union Foundation Inc New York NY 10004 PC Employee Matching 1,000 00 909 Montgomery Street Suite 400 American Himalayan Foundation San Francisco CA 94133 PC Employee Matching 7,000 00 1060 Amsterdam Avenue Amsterdam Nursing Home Corporation New York NY 100025 PC Employee Matching 200 00 219 10 36th Avenue Animal Rescue of Queens Inc Bayside NY 11361 PC Employee Matching 100 00 5048 N Jackson Ave Autism Science Center Fresno CA 93740 PC Employee Matching 412 00 1040 Oradell Avenue Bergen Catholic High School Oradell NJ 07649 PC Employee Matching 500 00 1047 Amsterdam Avenue Cathedral Church of St John the Divine New York NY 10025 PC Employee Matching 50000 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

116 John Street 19th Floor Center for Family Representation New York NY 10038 PC Employee Matching 400 .0O 445 Park Avenue Child Mind Institute New York NY 10022 PC Employee matching 5002.0 Rochelle Korman Esq 805 Third Avenue Citymeals On Wheels New York NY 10022 PC Employee Matching 108 00 13 Oak Drive Colgate University Hamilton NY 13346 1398 PC Employee Matching 7,00000 475 Riverside Dr Room405 Commonweal Foundation New York NY 10115 PC Employee Matching 1002.0 510 Saint Edwards Street Third Floor Community Roots Charter School Brooklyn NY 11205 PC Employee Matching 500 00 S Penn Plaza 2nd Floor Covenant House New York NY 10001 PC Employee Matching 2,500 00 207 West 25th Street 11th Floor Democracy Now New York NY 10001 PC Employee Matching 200 00 333 7th Avenue 2nd Floor Doctors Without Borders USA New York NY 10001 5004 PC Employee Matching 1,600 00 325 Commerce Street Fabretto Childrens Foundation Inc Alexandria VA 22314 PC Employee Matching 100 00 75 Broad Street Suite 304 Foundation for Independent Artists New York NY 10004 PC Employee Matching 400 00 113 Dexter Avenue Friends of KEXP North Seattle WA 98109 PC Employee Matching 150 .0o 1455 Mandalay Beach Road From the Heart Productions Inc Oxnard CA 93035 PC Employee Matching 500 00 370 Lancaster Ave Haverford College Haverford PA 19041 PC Employee Matching 300 00 One World Aveue Heifer Project International Little Rock AR 72201 PC Employee Matching 600 00 PO Box 55 Himalayan Cataract Project Inc Waterbury VT 05676 PC Employee Matching 2,000 00 57 Willoughby Street 2nd Floor Housing Works Brooklyn NY 11201 PC Employee Matching 5002.0 1600 Constance Street Kingsley House New Orleans LA 70130 PC Employee Matching 400 00 247 East 20th Street Learning Spring School New York NY 10003 PC Employee Matching 500 00 1311 Mamaroneck Avenue Suite 310 Leukemia & Lymphoma Society White Plains N Y10605 PC Employee Matching 100 00 PO Box 320009 Lowell Alumni Association San Francisco CA94132 PC Employee Matching 1,000 -Lo- Biology Finance Office Attn Alison Salie Massachusetts Institute of Technology Cambridge MA 02139 PC Employee matching 5,00000 1275 York Avenue Memorial Sloan Kettering Cancer Center New York NY 10065 PC Employee Matching 200 00 PO Box 1595 Movernber Inc Culver City CA 90232 PC Employee Matching 10000 1205 N Rampart St New Orleans Jazz & Heritage Foundation Inc New Orleans LA 70116 PC Employee Matching 600 00 240 Convent Avenue Parent Teacher Association of the High School of Math Science and Engineering New York NY 10031 PC Employee Matching 2,000 00 2560 Ninth St Suite 31S B Partners Asia (formerly) Community Partners International Berkeley CA 94710 PC Employee Matching 2,00000 434 W 33rd Street Planned Parenthood Federation of America New York NY 10001 PC Employee Matching 600 00 325 Science Center President & Fellows of Harvard College Cambridge MA 02138 PC Employee Matching 5,000 00 THE SIMONS FOUNDATION INC 2014 FORM 990 PF STATEMENT 16 13 3794889 PART XV LINE 3B SCHEDULE OF GRANTS APPROVED FOR FUTURE PAYMENT

100 Mission Drive Red Cloud Indian School Pine Ridge SD 57770 PC Employee matching 250 00 826 Broadway 9th Floor Robin Hood New York NY 10003 PC Employee Matching 6002.0 1 Civic Center Plaza Ste 200 Scenic Hudson Inc Poughkeepsie NY 12601 PC Employee Matching 1002.0 490 Hudson Street School Community Council The John Melser Charrette School PS 3 New York NY 10014 PC Employee Matching 1,200 .0O 650 Elm Street Special Olympics New Hampshire Manchester NH 03101 PC Employee Matching 100 00 501 St Jude Place St Jude Children s Research Hospital Memphis TN 38105 PC Employee Matching 1,000 00 208 Columbus Avenue St Martin de Porres Academy New Haven CT 06519 PC Employee Matching 2,500 00 230 Administration Stony Brook Foundation Inc Stony Brook NY 11794 1188 PC Employee Matching 2,000 .0O 481 Broadway 3rd Floor Storyville Center for the Spoken Word New York NY 10013 PC Employee Matching 200 00 900 South Crouse Ave Syracuse University Syracuse NY 13244 PC Employee Matching 400 00 101 Rockland Cir The Andrew McDonough B+ Foundation Wilmington DE 19803 PC Employee Matching 100 00 354 E Midland Ave The Dancers Dream Fund Inc Paramus NJ 7652 PC Employee Matching 400 00 633 Third Avenue 14th Floor The Fresh Air Fund New York NY 10017 PC Employee Matching 200 00 201 Mission Street The Nature Conservancy San Francisco CA94105 PC Employee Matching 600 00 535 West 116th Street The Trustees of Columbia University in the City of New York New York NY 10027 PC Employee Matching 400 00 535 West 116th Street The Trustees of Columbia University in the City of New York New York NY 10027 PC Employee Matching 200 00 370 Ja mes Street Suite 403 United Way of Greater New Haven New Haven CT 06513 PC Employee Matching 2,500 00 171 Broadmead University NOW Day Nursery Princeton NY 08540 PC Employee Matching 800 00 410 Liberty Street Urban Ministries of Durham Durham NC 27701 PC Employee Matching 400 00 161 Sky Meadow Drive Villa Maria School Stamford CT 06903 PC Employee Matching 500 00 1903 West Michigan Avenue Western Michigan University Foundation Kalamazoo MI 49008 5167 PC Employee Matching 100 00 4548 Market Street WHYY Inc Philadelphia PA 19139 PC Employee Matching 200 00 149 New Montgomery Street Floor 6 W ikimedia Foundation Inc San Francisco CA94105 PC Employee Matching 100 00 160 Varick Street WNYC Radio New York NY 10013 PC Employee Matching 4302.0 5644 Co (cord Avenue Women s Center of Jacksonville Jacksonville FL 32211 PC Employee Matching 200 00 86 Main Street Yonkers Partners in Education Yonkers NY 10701 PC Employee Matching 3,000 00

Total Grants Approved for Future Payment 207,623,606 71 The Simons Foundation EIN#: 13 - 3794889 Form 990-PF FYE: 12/31/2014

Form 990-PF, Part II, Line 14

12/31/2014 Leasehold Improvements 17,672,677 Furniture and Fixtures 806,876 Computer Equipment 1,097,269 Capitalized Software 283,792 Artwork 842,290 Accumulated depreciation -

Net PP&E 20,702,904

Form 990-PF, Part I, Line 19

12/31/2014 Depreciation expense acct 060 2,209,361 Part 1, Line 19

Total 2,209,361

ATTACHMENT 17 THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE King's College London 79,675 9/1/2013 46,296 Contactin-associated protein-like 2 (CASPR2, encoded by the gene CNTNAP2) is a cell adhesion molecule that is 5/15/2014, No N/A N/A MRC Centre for Developmental essential for proper neuronal function Common and rare genetic variations in CNTNAP2 are associated with an 5/15/2015 Neurobiology increased risk of autism spectrum disorders A recessive mutation in exon 22 of the gene causes a syndromic form 4th Floor, New Hunt's House of autism called cortical dysplasia-focal epilepsy syndrome (CDFE) CDFE is a common cause of intractable epilepsy Guy's Campus in children, and the cerebral cortex of individuals with CDFE often shows a disorganized structure London SE1 1UL Ehor Peles, in collaboration with Oscar Marm and Daniel Geschwind, is aiming to characterize two new CNTNAP2 mouse models One model bears a mutation in exon 22, similar to the human mutation In the second model, a marker gene replaces the first exon of CNTNAP2 The presence of the marker should allow the researchers to better understand the cellular changes that occur in mice with CNTNAP2 mutations Peles's lab has also generated model mice that lack CASPR2 completely

The group plans to obtain detailed anatomical, developmental and behavioral data from mice with the exon 22 mutation, and then compare the data with those obtained from mice lacking CASPR2 This comparison could reveal underlying mechanisms relevant to autism The researchers also plan to characterize the basic electrophysiological properties of microcircuits in the cerebral cortex of the model mice Finally, they plan to examine the effects of several drugs that may modify social behavior in these newly generated model mice

King's College London 79,885 9/1/2014 0 Contactin-associated protein-like 2 (CASPR2, encoded by the gene CNTNAP2) is a cell adhesion molecule that is 5/15/2015 No N/A N/A MRC Centre for Developmental essential for proper neuronal function Common and rare genetic variations in CNTNAP2 are associated with an Neurobiology increased risk of autism spectrum disorders A recessive mutation in exon 22 of the gene causes a syndromic form 4th Floor, New Hunt's House of autism called cortical dysplasia-focal epilepsy syndrome (CDFE) CDFE is a common cause of intractable epilepsy Guy's Campus in children, and the cerebral cortex of individuals with CDFE often shows a disorganized structure London SE1 1UL Ehor Peles, in collaboration with Oscar Marm and Daniel Geschwind, is aiming to characterize two new CNTNAP2 mouse models One model bears a mutation in exon 22, similar to the human mutation In the second model, a marker gene replaces the first exon of CNTNAP2 The presence of the marker should allow the researchers to better understand the cellular changes that occur in mice with CNTNAP2 mutations Peles's lab has also generated model mice that lack CASPR2 completely

The group plans to obtain detailed anatomical, developmental and behavioral data from mice with the exon 22 mutation, and then compare the data with those obtained from mice lacking CASPR2 This comparison could reveal underlying mechanisms relevant to autism The researchers also plan to characterize the basic electrophysiological properties of microcircuits in the cerebral cortex of the model mice Finally, they plan to examine the effects of several drugs that may modify social behavior in these newly generated model mice THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE Birkbeck College 223,738 1/1/2013 223,738 The younger siblings of children diagnosed with autism are at an increased risk for autism themselves By studying 3/1/2014, No N/A N/A Malet Street these at-risk babies, we can better understand the development of the condition and this, in turn, may lead to 3/1/2015 London, WC1E 7HX, United Kingdom more effective early treatments It remains challenging, however, to study brain function in a safe and effective way in young babies Mark Johnson and his colleagues at the University of London have been developing a new method of brain imaging called functional near-infrared spectroscopy (fNIRS), which involves weak beams of light that are absorbed differently in active vs inactive parts of the brain

Johnson plans to bring together a group of internationally recognized experts to determine how effective this new method is, by directly comparing it to existing methods that are more difficult to use with awake babies (e g , functional magnetic resonance imaging, or fMRI) or that have inferior spatial resolution (e g, electroencephalography, or EEG)

The researchers aim to assess the reliability and accuracy of the new method in a practical laboratory context by testing and then retesting the same babies one week later Finally, they plan to gather fNIRS measurements from at risk siblings and low-risk controls at 6 months of age, and then again about 30 months later The researchers hope their methods can be used to look for differences in brain function between at-risk and low-risk babies during infancy, which could be related to later-emerging symptoms of autism

Birkbeck College 290,707 1/1/2014 289,635 The younger siblings of children diagnosed with autism are at an increased risk for autism themselves By studying 3/1/2015 No N/A N/A Malet Street these at-risk babies, we can better understand the development of the condition and this, in turn, may lead to London, WC1E 7HX, United Kingdom more effective early treatments It remains challenging, however, to study brain function in a safe and effective way in young babies Mark Johnson and his colleagues at the University of London have been developing a new method of brain imaging called functional near-infrared spectroscopy (fNIRS), which involves weak beams of light that are absorbed differently in active vs inactive parts of the brain

Johnson plans to bring together a group of internationally recognized experts to determine how effective this new method is, by directly comparing it to existing methods that are more difficult to use with awake babies (e g , functional magnetic resonance imaging, or fMRI) or that have inferior spatial resolution (e g, electroencephalography, or EEG)

The researchers aim to assess the reliability and accuracy of the new method in a practical laboratory context by testing and then retesting the same babies one week later Finally, they plan to gather fNIRS measurements from at risk siblings and low-risk controls at 6 months of age, and then again about 30 months later The researchers hope their methods can be used to look for differences in brain function between at-risk and low-risk babies during infancy, which could be related to later-emerging symptoms of autism THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE Deakin University 146,555 1/1/2013 146,555 There are few pharmacological options to treat autism, and the currently available drugs target only specific 3/1/2014, No N/A N/A Locked Bag 20000 symptoms, such as disruptive behavior Several lines of evidence suggest the presence of high levels of oxidative 3/1/2015 Geelong, VIC 3220, Australia stress in autism reduced levels of glutathione, the brain's predominant antioxidant, oxidative damage to lipids and other cellular components, and differences in antioxidant gene expression between people with autism and controls

In other neuropsychiatric disorders with similar patterns of oxidative stress, clinical trials on the use of the antioxidant N-acetyl cysteine (NAC), which boosts glutathione, have shown promising results NAC also impacts the neurotransmitter glutamate, and changes in glutamate levels are also seen in autism NAC has an excellent tolerability profile, and is a relatively natural treatment option that is currently available as a nutritional supplement A pilot study of NAC treatment for autism has shown both a reduction in irritability and good tolerability of the compound These promising results need to be replicated in a larger and more definitive study

Michael Berk and his team at Deakin University in Melbourne, Australia are conducting a randomized, placebo- controlled clinical trial of NAC with 80 children who have recently received a diagnosis of autism They plan to administer a daily oral dose of NAC for six months, in order to test the efficacy and tolerability of NAC in treating core symptoms of the disorder if NAC proves to be superior to the placebo in improving autism symptoms, this could have a significant effect on the treatment of autism This research project may also provide new insights into the pathophysiology of autism and targets for future drug development

Erasmus Universitair Medisch Centrum 54,450 9/1/2013 54,450 Angelman syndrome is a severe neurodevelopmental disorder affecting 1 15 000 individuals Autism spectrum 11/1/2014, No N/A N/A Rotterdam disorder (ASD) is reported in most of the Angelman syndrome children it is caused by loss of a functional U BE3A 11/1/2015 Dr Molewaterplein 50 gene However, it is not clear to what extend the UBE3A gene plays a role in brain development (i e hardwiring of 3015 GE Rotterdam, The Netherlands the brain) When considering a therapy, it is essential that we know if, and at what age, the neurological symptoms are reversible To phrase this question simply "Imagine if we had the perfect drug, (e g repair the UBE3A gene in all cells), how successful would such a treatment be for my 5/10/20 years old child?"

We have now engineered a mouse (Ube3a-inducible mice) in which the UBE3A gene is non-functional when born These mice have 'Angelman syndrome' and show a number of behavioral deficits, including deficits that are relevant for the autism field However, by just a simple injection at any desired age, we can now restore UBE3a gene function in every cell of the mouse, including the brain Hence, this represents the ultimate 'cure' We now propose to restore gene function at various ages, and assess whether these genetically 'cured' mice show a rescue of the phenotypes Our preliminary data suggest that a rescue is possible, but that the age at which this can be accomplished (called critical period) depends on the behavioral task We now want to further investigate this

Although not offering a specific therapeutic intervention for patients, this work will allow us to investigate what the role of UBE3A in brain development is More specifically, we will know what the critical period is for being able to reverse specific behavioral deficits This knowledge is also essential to develop drug screen strategies, in which a behavioral rescue is the read-out THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE Erasmus Universitair Medisch Centrum 108,900 5/14/14, 54,450 Angelman syndrome is a severe neurodevelopmental disorder affecting 1 15 000 individuals Autism spectrum 11/1/2015 No N/A N/A Rotterdam 11/25/14 disorder (ASD) is reported in most of the Angelman syndrome children it is caused by loss of a functional U BE3A Dr Molewaterplein 50 gene However, it is not clear to what extend the UBE3A gene plays a role in brain development (i e hardwiring of 3015 GE Rotterdam, The Netherlands the brain) When considering a therapy, it is essential that we know if, and at what age, the neurological symptoms are reversible To phrase this question simply "Imagine if we had the perfect drug, (e g repair the UBE3A gene in all cells), how successful would such a treatment be for my 5/10/20 years old child?"

We have now engineered a mouse (Ube3a-inducible mice) in which the UBE3A gene is non-functional when born These mice have 'Angelman syndrome' and show a number of behavioral deficits, including deficits that are relevant for the autism field However, by just a simple injection at any desired age, we can now restore UBE3a gene function in every cell of the mouse, including the brain Hence, this represents the ultimate 'cure' We now propose to restore gene function at various ages, and assess whether these genetically 'cured' mice show a rescue of the phenotypes Our preliminary data suggest that a rescue is possible, but that the age at which this can be accomplished (called critical period) depends on the behavioral task We now want to further investigate this

Although not offering a specific therapeutic intervention for patients, this work will allow us to investigate what the role of UBE3A in brain development is More specifically, we will know what the critical period is for being able to reverse specific behavioral deficits This knowledge is also essential to develop drug screen strategies, in which a behavioral rescue is the read-out

Governing Council of the University of 126,449 7/1/2013 126,449 Knot Theory, Algebra, and Higher Algebra 2/28/2014 No N/A N/A Toronto Bahen Building, 6th Floor 40 St George St Toronto , ON M55 2K3 , Canada Governing Council of the University of 119,471 7/1/2013 119,471 Evolution equations that describe wave phenomena relevant to physical processes arising in fluid mechanics, 8/31/2014 No N/A N/A Toronto nonlinear optics and plasma physics in two directions Bahen Building, 6th Floor 40 St George St 1 The theory of ocean waves The problem of water waves can be expressed as a dynamical free boundary Toronto, ON M55 2K3, Canada problem that stems from the full Euler equations for an incompressible flow The equations have the form of a Hamiltonian PDE, a fact reflected in conservation laws, the theory of its instabilities, and the classes of special solutions these equations exhibit The research proposal has two components The first concerns the mathematical analysis of the PDEs for free surface water waves, starting from the classical questions of existence and regularity of solutions, and continuing with a more detailed phase space analysis of the evolution of solutions The analysis has motivated new approaches to numerical simulations of water waves in several problems, such as in modeling solitary wave collisions and interactions A culmination of this study will be the construction of a sequence of normal form transformations for the full equations of water waves The second thrust involves projects with an applied mathematics perspective, important topics include tsunami modeling, large amplitude nonlinear wave interactions, and wave propagation over rough, and possibly random, bottom topography

2 Nonlinear waves in optics and plasmas The nonlinear Schroedinger (NLS) equation is a canonical equation that appears in many fields of physics it arises ubiquitously as a model for the envelope dynamics of waves and is used frequently in optics, plasmas and fluids in quantum physics, it arises as a mean field equation for a many-body boson system in a confining potential and for Bose-Einstein condensation in dilute gases The work concentrates on two central features (i) the phenomenon of self-focusing' or wave collapse' associated to the blowup of solutions and its counterpart, the wellposedness theory and long-time dynamics, (ii) the dynamics of solitary waves These questions will be at the centre of the research for NLS type equations of physical relevance such as the Derivative NLS equation for dispersive Alfven waves and the Zakharov system for Langmuir turbulence THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE Hebrew University of Jerusalem 61,625 11/1/2012 61,625 Recent studies identified mutations in hundreds of genes that may contribute to the risk of autism spectrum 1/1/2014, No N/A N/A Edmond Safra Campus disorders (ASDs) We analyzed those genes and found that many of them produce specific type of proteins that are 1/1/2015 Givat Ram 91904 involved in the way the DNA is packed in our cells Specifically, some of the recurrent mutations are in genes Jerusalem Israel 91904 involved in a tightly packed form of DNA The regions of tightly packed DNA are involved in several different biological processes, which are essential for different stages of brain development However, it is not clear which one of the processes is relevant to autism The aim of our project is to study those processes using blood cells that were collected from individuals with different mutations We will also test to see if the individuals with the mutations are more likely to have similar behavioral and cognitive characteristics The results will allow us to identify shared mechanisms leading to autism

Independent University of Moscow 200,000 3/1/2013 200,000 Support funding of Simons IUM Fellowships, Simons Stipdends for Students and Graduate Students, and the Simons 1/15/2014 No N/A N/A Leninskii Street 2a, Office 4a-03 Award for the former Winners of Pierre Deligne and Dynasty contests Moscow 119046, Russian Federation Independent University of Moscow 200,000 3/1/2014 200,000 Support funding of Simons IUM Fellowships, Simons Stipdends for Students and Graduate Students, and the Simons 1/15/2015 No N/A N/A Leninskii Street 2a, Office 4a-03 Award for the former Winners of Pierre Deligne and Dynasty contests Moscow 119046, Russian Federation Institut Pasteur 174,960 5/30/2013, 174,960 Autism spectrum disorders represent a challenge for geneticists because of the heterogeneity of causes Still, in a 11/1/2013, No N/A N/A 25-28 Rue du Dr Roux Paris Cedex 11/30/2013 subset of people with autism, certain deleterious gene mutations have been identified, and most are involved in 11/1/2014 15 PARIS 75724, France the formation of synapses - the points of contact between neurons At first, these mutations alone were thought to be sufficient to cause autism, but studies suggest that the inheritance of 'modifier genes,' which alter the expression of other genes, might contribute to the wide behavioral variability observed in individuals with autism

Thomas Bourgeron and his colleagues at Institut Pasteur in France are aiming to obtain a detailed genomic profile of 15 families with more than one affected member (known as multiplex families) It is possible to sequence the whole genome of an individual and to identify small genetic alterations in the nine families that Bourgeron has studied so far, deleterious mutations have been identified in NLGN4X, SHANK1, SHANK2, CNTN6 and CNTNAP2 In the six remaining families, mutations have not yet been identified, but the presence of two affected relatives with autism spectrum disorder makes it likely that an inherited genetic cause may be found

Elucidating the gene-gene interactions at the synapses of people with autism could benefit autism research in two ways by improving the interpretation of genetic tests for autism and by improving the design of animal models for autism Rather than being based on the deletion of a single gene, the model animals could eventually carry multiple genetic mutations, as observed in people with the disorder THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT'S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE Institut Pasteur 45,280 11/30/2014 45,280 Autism spectrum disorders represent a challenge for geneticists because of the heterogeneity of causes Still, in a 11/1/2014 No N/A N/A 25-28 Rue du Dr Roux Paris Cedex subset of people with autism, certain deleterious gene mutations have been identified, and most are involved in 15 PARIS 75724, France the formation of synapses - the points of contact between neurons At first, these mutations alone were thought to be sufficient to cause autism, but studies suggest that the inheritance of 'modifier genes,' which alter the expression of other genes, might contribute to the wide behavioral variability observed in individuals with autism

Thomas Bourgeron and his colleagues at Institut Pasteur in France are aiming to obtain a detailed genomic profile of 15 families with more than one affected member (known as multiplex families) It is possible to sequence the whole genome of an individual and to identify small genetic alterations in the nine families that Bourgeron has studied so far, deleterious mutations have been identified in NLGN4X, SHANK1, SHANK2, CNTN6 and CNTNAP2 In the six remaining families, mutations have not yet been identified, but the presence of two affected relatives with autism spectrum disorder makes it likely that an inherited genetic cause may be found

Elucidating the gene-gene interactions at the synapses of people with autism could benefit autism research in two ways by improving the interpretation of genetic tests for autism and by improving the design of animal models for autism Rather than being based on the deletion of a single gene, the model animals could eventually carry multiple genetic mutations, as observed in people with the disorder

International Mathematical Union 25,000 9/1/2013 11,000 The International Mathematical Union (IMU) has been very sensitive to the needs of mathematicians working in 10/31/2014 No N/A N/A Secretariat, Markgrafenstr 32 developing and economically disadvantaged countries In order to consolidate the efforts of the IMU to help such D-10117 Berlin, Germany mathematicians through its different agencies, it established in 2011 the Commission for Developing Countries (CDC) which is responsible for all IMU initiatives to help mathematicians from developing countries One of the major problems faced by mathematicians in the so-called third world is that of isolation On one hand their countries cannot afford to provide them with adequate financial support to have basic facilities like well equipped libraries However, with the advent of the internet, this problem is mitigated to a certain extent On the other hand, these mathematicians work in understaffed mathematics departments and so are subjected to very heavy teaching loads, thereby having very little time for pursuing their individual research interests Further, each mathematician is often the only person working in his/her research area and so (s)he cannot have useful and stimulating mathematical discussions which are essential to generate new ideas in research Such mathematicians, therefore, need time off from their usual duties to recharge their intellectual batteries and to initiate collaborative research with mathematicians working in centres of excellence elsewhere in the world under favourable working conditions The CDC helps mathematicians from developing or economically disadvantaged countries to overcome this problem by funding their travel to a centre of excellence for collaborative research

International Mathematical Union 25,000 9/1/2014 0 The International Mathematical Union (IMU) has been very sensitive to the needs of mathematicians working in (10/31/2015) No N/A N/A Secretariat, Markgrafenstr 32 developing and economically disadvantaged countries In order to consolidate the efforts of the IMU to help such D-10117 Berlin, Germany mathematicians through its different agencies, it established in 2011 the Commission for Developing Countries (CDC) which is responsible for all IMU initiatives to help mathematicians from developing countries One of the major problems faced by mathematicians in the so-called third world is that of isolation On one hand their countries cannot afford to provide them with adequate financial support to have basic facilities like well equipped libraries However, with the advent of the internet, this problem is mitigated to a certain extent On the other hand, these mathematicians work in understaffed mathematics departments and so are subjected to very heavy teaching loads, thereby having very little time for pursuing their individual research interests Further, each mathematician is often the only person working in his/her research area and so (s)he cannot have useful and stimulating mathematical discussions which are essential to generate new ideas in research Such mathematicians, therefore, need time off from their usual duties to recharge their intellectual batteries and to initiate collaborative research with mathematicians working in centres of excellence elsewhere in the world under favourable working conditions The CDC helps mathematicians from developing or economically disadvantaged countries to overcome this problem by funding their travel to a centre of excellence for collaborative research THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/( DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT'S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE McGill University 56,688 9/1/2013 56,688 To investigate applications of string theory to basic conceptual puzzles in quantum gravity The focus will be on 10/31/2014 No N/A N/A Rutherford Physics Building techniques involving the holographic correspondence, which is a relation between quantum gravity in a region of 3600 Rue University space-time and a quantum field theory in one less space-time dimension These techniques will apply to two Montreal, QC H3A 2T8, Canada particularly interesting classes of problems, involving black holes and cosmology

Black hole physics provides an ideal theoretical laboratory for the study of quantum gravity However, almost all of the impressive string theoretic results apply only to supersymmetric black holes, which differ qualitatively from the non-supersymmetric black holes relevant for astrophysics Moreover, while many of these results involve the physics of black hole horizons, they do not shed light on the nature of physics at the black hole singularity The research goal is to use holographic techniques to develop a theory of non-supersymmetric black holes which will address these issues

The second set of questions is motivated by recent astronomical observations indicating that the universe began with a big bang singularity, followed by a period of inflation Neither of these two features - the cosmological singularity and the exponentially expanding phase - have been successfully described in string theory These problems, which must be solved if string theory is to successfully describe the observable universe, also provide the exciting prospect of contact with experimental data The research involves the construction of holographic theories of quantum cosmology, which can potentially describe the quantum behaviour of the universe at its earliest times

In both of the above cases, the research involves specific systems for which the holographic correspondence can be made precise For example, in 2+1 space-time dimensions one can study gravity at the quantum mechanical level and provide an exact accounting of the microscopic states of a quantum black hole Likewise, in this simplified setting one can compute the wave function of the universe" in a precise manner A second, related set of questions involves higher spin gravity, a theory in which the geometric structure of general relativity is extended in a way which allows precise statements about the holographic dual theory

McGill University 56,688 3/1/2014 38,151 To investigate applications of string theory to basic conceptual puzzles in quantum gravity The focus will be on 10/31/2014 No N/A N/A Rutherford Physics Building (18,537) techniques involving the holographic correspondence, which is a relation between quantum gravity in a region of 3600 Rue University space-time and a quantum field theory in one less space-time dimension These techniques will apply to two Montreal, QC H3A 2T8, Canada particularly interesting classes of problems, involving black holes and cosmology

Black hole physics provides an ideal theoretical laboratory for the study of quantum gravity However, almost all of the impressive string theoretic results apply only to supersymmetric black holes, which differ qualitatively from the non-supersymmetric black holes relevant for astrophysics Moreover, while many of these results involve the physics of black hole horizons, they do not shed light on the nature of physics at the black hole singularity The research goal is to use holographic techniques to develop a theory of non-supersymmetric black holes which will address these issues

The second set of questions is motivated by recent astronomical observations indicating that the universe began with a big bang singularity, followed by a period of inflation Neither of these two features - the cosmological singularity and the exponentially expanding phase - have been successfully described in string theory These problems, which must be solved if string theory is to successfully describe the observable universe, also provide the exciting prospect of contact with experimental data The research involves the construction of holographic theories of quantum cosmology, which can potentially describe the quantum behaviour of the universe at its earliest times

In both of the above cases, the research involves specific systems for which the holographic correspondence can be made precise For example, in 2+1 space-time dimensions one can study gravity at the quantum mechanical level and provide an exact accounting of the microscopic states of a quantum black hole Likewise, in this simplified setting one can compute the wave function of the universe" in a precise manner A second, related set of questions involves higher spin gravity, a theory in which the geometric structure of general relativity is extended in a way which allows precise statements about the holographic dual theory THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE Medical Research Council-NIMR 99,983 8/30/2013 99,983 It is thought that during the origin of life on Earth there was a phase when the nucleic acid RNA served the dual 8/1/2014, No N/A N/A Francis Crick Avenue roles of information storage and catalysis The 'RNA world hypothesis' is strongly supported by much recent 8/1/2015 Cambridge Biomedical Campus biological work, but until our recentwork making ribonucleotides, there had been little by way of chemical Cambridge CB2 OQH, United Kingdom explanation as to how RNA might have been generated prebiotically on the early Earth So far so good, but quite a bit remains to be done if RNA itself is to be made, and the current proposal seeks funds to finish the job in particular, we want to i) find a route to activated purine nucleotides - we think we can do this from a by-product of the pyrimidine nucleotide synthesis n) sort out the chirality issue (certain molecules exist in left and right handed forms, and RNA is a polymer of right handed nucleotides) - we think we can do this using a crystallisation trick' followed by a phosphate-catalysed reactionm) find a route to glyceraldehyde which is a key intermediate in the synthesis, but which is not considered to have been a prebiotic feedstock moleculeiv) optimise conditions for stringing the activated nucleotides together to generate RNA

Medical Research Council-NIMR 99,983 2/28/2014 99,983 It is thought that during the origin of life on Earth there was a phase when the nucleic acid RNA served the dual 8/1/2015 No N/A N/A Francis Crick Avenue roles of information storage and catalysis The 'RNA world hypothesis' is strongly supported by much recent Cambridge Biomedical Campus biological work, but until our recentwork making ribonucleotides, there had been little by way of chemical Cambridge CB2 OQH, United Kingdom explanation as to how RNA might have been generated prebiotically on the early Earth So far so good, but quite a bit remains to be done if RNA itself is to be made, and the current proposal seeks funds to finish the job in particular, we want to i) find a route to activated purine nucleotides - we think we can do this from a by-product of the pyrimidine nucleotide synthesis n) sort out the chirality issue (certain molecules exist in left and right handed forms, and RNA is a polymer of right handed nucleotides) - we think we can do this using a crystallisation trick' followed by a phosphate-catalysed reactionm) find a route to glyceraldehyde which is a key intermediate in the synthesis, but which is not considered to have been a prebiotic feedstock moleculeiv) optimise conditions for stringing the activated nucleotides together to generate RNA

Medical Research Council-NIMR 200,000 8/30/2014 76,299 It is thought that during the origin of life on Earth there was a phase when the nucleic acid RNA served the dual 8/1/2015 No N/A N/A Francis Crick Avenue roles of information storage and catalysis The 'RNA world hypothesis' is strongly supported by much recent Cambridge Biomedical Campus biological work, but until our recentwork making ribonucleotides, there had been little by way of chemical Cambridge CB2 OQH, United Kingdom explanation as to how RNA might have been generated prebiotically on the early Earth So far so good, but quite a bit remains to be done if RNA itself is to be made, and the current proposal seeks funds to finish the job in particular, we want to i) find a route to activated purine nucleotides - we think we can do this from a by-product of the pyrimidine nucleotide synthesis n) sort out the chirality issue (certain molecules exist in left and right handed forms, and RNA is a polymer of right handed nucleotides) - we think we can do this using a crystallisation trick' followed by a phosphate-catalysed reactionm) find a route to glyceraldehyde which is a key intermediate in the synthesis, but which is not considered to have been a prebiotic feedstock moleculeiv) optimise conditions for stringing the activated nucleotides together to generate RNA

National Centre for Biological Sciences 200,000 7/1/2013, 26,448 To establish a Centre dedicated to the theoretical study of molecules, cells, and organisms as 'living machines' 8/31/2014, No N/A N/A GKVK Post, Bellary Road 12/31/2013 imperfectly optimized products of natural selection, which consume energy to achieve specific goals The Centre 8/31/2015 Bangalore 560065, India will be embedded within, and intimately connected to, the broader NCBS experimental research environment it will initially bring together existing research groups under a common theme, and will be expanded through the aggressive recruitment of new permanent and visiting faculty We will institute summer schools for undergraduates, to expose a new generation of students from mathematics, physical sciences and engineering to challenging problems in modern biology Taking advantage of NCBS's excellent administrative infrastructure and research environment, we aim to create a new global benchmark for experiment-theory collaborations THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE National Centre for Biological Sciences 100,000 7/1/2014 0 To establish a Centre dedicated to the theoretical study of molecules, cells, and organisms as 'living machines' 8/31/2015 No N/A N/A GKVK Post, Bellary Road imperfectly optimized products of natural selection, which consume energy to achieve specific goals The Centre Bangalore 560065, India will be embedded within, and intimately connected to, the broader NCBS experimental research environment it will initially bring together existing research groups under a common theme, and will be expanded through the aggressive recruitment of new permanent and visiting faculty We will institute summer schools for undergraduates, to expose a new generation of students from mathematics, physical sciences and engineering to challenging problems in modern biology Taking advantage of NCBS's excellent administrative infrastructure and research environment, we aim to create a new global benchmark for experiment-theory collaborations

Peking University 65,262 2/28/2014, 65,262 Funding for Two Simons Postdoctoral Fellowships at Beijing International Center for Mathematical Research at 12/1/2014 No N/A N/A College of Life Sciences 11/30/2014 Peking University, funding for Simons Visiting Chair Professor for two months, and funding for Short-Term Visitors Pekin g Universit y Bei j in g 100871, China and to su pp ort Geometr y Seminars at Pekin g Universit y The Abdus Salam International Centre 150,000 7/1/2013 150,000 The Abdus Salam International Centre for Theoretical Physics (ICTP) is the first and leading global institution for 8/31/2014, No N/A N/A for Theoretical Physics fundamental research and development, with special focus on developing countries It is run by scientists and 8/31/2015 Strada Costiera 11 operates under a tripartite agreement between the Italian government (main source of funding), UNESCO and 34151 Trieste, Italy IAEA For almost 50 years ICTP has supported tens of thousands of scientists from all corners of the world with training and research activities in Trieste and in developing countries At ICTP, visiting scientists can find some of the brightest minds in physics and mathematics ICTP scientists have played important roles by performing the highest level of scientific research while at the same time organising activities in developing countries as well as educating and working with the local scientists Over the years this has covered several generations of scientists that have used the ICTP programmes at different stages of their careers As such ICTP has been the world premier scientific institution for sustainable international cooperation

The Abdus Salam International Centre 150,000 7/1/2014 4,865 The Abdus Salam International Centre for Theoretical Physics (ICTP) is the first and leading global institution for 8/31/2015 No N/A N/A for Theoretical Physics fundamental research and development, with special focus on developing countries It is run by scientists and Strada Costiera 11 operates under a tripartite agreement between the Italian government (main source of funding), UNESCO and 34151 Trieste, Italy IAEA For almost 50 years ICTP has supported tens of thousands of scientists from all corners of the world with training and research activities in Trieste and in developing countries At ICTP, visiting scientists can find some of the brightest minds in physics and mathematics ICTP scientists have played important roles by performing the highest level of scientific research while at the same time organising activities in developing countries as well as educating and working with the local scientists Over the years this has covered several generations of scientists that have used the ICTP programmes at different stages of their careers As such ICTP has been the world premier scientific institution for sustainable international cooperation THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE The Governors of the University of 340,554 2/28/2013, 284,411 Several genes have been identified that contribute to the risk of developing autism spectrum disorders Studies of 7/1/2014, No N/A N/A Alberta 5/30/2013, (56,143) infants at high risk ('baby siblings' of children with autism) have yielded exciting new findings about the earliest 7/1/2015 Attn Research Accounts Receivables 8/30/2013, signs of the disorder, raising the hope that children could be diagnosed and therefore treated at an earlier age 3rd Floor Administration Building 11/30/2013 Edmonton, Alberta T6G 2M7, Canada Under the leadership of Lonnie Zwaigenbaum, scientists across North America who focus on genetics and early detection in autism are planning to establish the first databank, or' biorepository,' containing rich behavioral information and genetic material from families of children with the disorder By bringing together detailed information about early development and outcomes in large groups of baby siblings, and genetic analyses, efforts to develop gene-based early detection tools may be accelerated indeed, if genetic biomarkers could be used to help predict which infants are most likely to develop autism, this could revolutionize opportunities for earlier diagnosis and treatment

Once the biorepository is created, the researchers plan to conduct genetic analyses using state-of-the-art microarray techniques to detect potential causative genetic variants, and then assess whether these variants are informative for early diagnosis Once the initial analyses are completed, the biorepository may be made available to the broader scientific community

The development of genetic testing strategies based on these discoveries has the potential to transform clinical practice and ultimately increase the quality of life for the many individuals and families affected by autism What's more, the biorepository is expected to provide an invaluable long-term resource to the scientific community and lead to further understanding of the biological mechanisms underlying early expression of the disorder

The Governors of the University of 85,833 2/28/2014 (85,833) Several genes have been identified that contribute to the risk of developing autism spectrum disorders Studies of 7/1/2015 No N/A N/A Alberta infants at high risk ('baby siblings' of children with autism) have yielded exciting new findings about the earliest Attn Research Accounts Receivables signs of the disorder, raising the hope that children could be diagnosed and therefore treated at an earlier age 3rd Floor Administration Building Edmonton, Alberta T6G 2M7, Canada Under the leadership of Lonnie Zwaigenbaum, scientists across North America who focus on genetics and early detection in autism are planning to establish the first databank, or' biorepository,' containing rich behavioral information and genetic material from families of children with the disorder By bringing together detailed information about early development and outcomes in large groups of baby siblings, and genetic analyses, efforts to develop gene-based early detection tools may be accelerated indeed, if genetic biomarkers could be used to help predict which infants are most likely to develop autism, this could revolutionize opportunities for earlier diagnosis and treatment

Once the biorepository is created, the researchers plan to conduct genetic analyses using state-of-the-art microarray techniques to detect potential causative genetic variants, and then assess whether these variants are informative for early diagnosis Once the initial analyses are completed, the biorepository may be made available to the broader scientific community

The development of genetic testing strategies based on these discoveries has the potential to transform clinical practice and ultimately increase the quality of life for the many individuals and families affected by autism What's more, the biorepository is expected to provide an invaluable long-term resource to the scientific community and lead to further understanding of the biological mechanisms underlying early expression of the disorder

Tsinghua University Education 30,000 12/31/2013 30,000 Tsinghua Sanya International Mathematics Forum - become a base for scientific innovations through interactions 12/1/2013, No N/A N/A Foundation between leading mathematicians and core research groups in pure and applied mathematics, statistics, theoretical 2/28/2015 Mathematical Sciences Center physics, theoretical biology Tsinghua University Room 131 Jin Chun Yuan West Building Haidian District THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE Tsinghua University Education 120,000 4/25/2014, 50,623 Tsinghua Sanya International Mathematics Forum - become a base for scientific innovations through interactions 12/1/2013, No N/A N/A Foundation 6/25/2014, between leading mathematicians and core research groups in pure and applied mathematics, statistics, theoretical 2/28/2015 Mathematical Sciences Center 9/30/2014, physics, theoretical biology Tsinghua University Room 131 12/22/2014 Jin Chun Yuan West Building Haidian District Universita degh studs di Trento 200,000 7/28/2014, 62,431 Sequencing data suggest that inorganic molecules sequestered from the environment, namely iron-sulfur clusters, 11/1/2014 No N/A N/A Via Belenzani 12 8/29/2014 are crucial for extant life and were exploited early in evolution These metal clusters play structural and catalytic Trento 38122, Italy roles inside cells and are particularly important for metabolic processes such as respiration Nevertheless, nearly all investigations into the impact of iron-sulfur clusters on the origins of life have focused on a narrow set of environmental conditions not compatible with other chemical scenarios thought to be important for protocellular survival We plan to address this problem by evaluating the ability of iron-sulfur clusters to form in environments compatible with other prebiotically important processes, such as nucleotide synthesis and compartment formation Finally, we will ascertain whether the identified conditions and metal clusters are able to mediate chemical transformations that could have facilitated the emergence of life on Earth

Universite Cheikh Anta Diop de Dakar, 80,000 5/31/2013, 80,000 Non-Linear Analysis, Geometry and Application Project 6/30/2014, No N/A N/A Senegal 11/30/2013 6/30/2015 Mathematics & Decision Department B P 16889 Dakar-Fann , Sene gal Universite Cheikh Anta Diop de Dakar, 80,000 5/31/2014, 17,383 Non-Linear Analysis, Geometry and Application Project 6/30/2015 No N/A N/A Senegal 11/30/2014 Mathematics & Decision Department B P 16889 Dakar-Fann , Sene gal University of Botswana 80,000 5/31/2013, 80,000 The grant has two components (i) Teaching and (n) Research Teaching is going on mainly at the University of 6/30/2014, No N/A N/A Department of Mathematics 11/30/2013 Botswana where 4 MSC students are being supported to undertake studies in fulfillment of part I of the program 6/30/2015 Pvt Bag 00704 The students are enrolled in courses in Financial Mathematics (2 courses), Mathematical Biology (1 course) and Gaborone, Botswana Pure Mathematics (3 courses) This group of students forms the basis for future enrollment of PhD students for our p ro ject University of Botswana 80,000 5/31/2014, 76,146 The grant has two components (i) Teaching and (n) Research Teaching is going on mainly at the University of 6/30/2015 No N/A N/A Department of Mathematics 11/30/2014 Botswana where 4 MSC students are being supported to undertake studies in fulfillment of part I of the program Pvt Bag 00704 The students are enrolled in courses in Financial Mathematics (2 courses), Mathematical Biology (1 course) and Gaborone, Botswana Pure Mathematics (3 courses) This group of students forms the basis for future enrollment of PhD students for our , p ro ject University of Geneva, Medical School 124,936 5/30/2013, 124,936 It is established that social contacts can activate brain reward circuits, which originate in a small nucleus at the tip 11/1/2014, No N/A N/A Rue Michel-Servet 1-1211 Geneve 4 11/30/2013 of the brain stem The integrity of synaptic transmission in this nucleus matures postnatally We have collected 11/1/2015 Geneva 1206, Switzerland preliminary data that suggest that SHank3, a protein deficient in the Phelan-McDermit syndrome, is required for the normal maturation of these synapses We therefore propose to test the hypothesis that impaired Shank3 function leads to impaired maturation, deficient synaptic transmission and eventually impaired social interactions Our pilot study may provide a proof of principle for the involvement of altered synaptic function in the reward circuit as a mechanism underlying disturbed social interaction in ASD

University of Geneva, Medical School 62,440 5/30/2014 62,440 It is established that social contacts can activate brain reward circuits, which originate in a small nucleus at the tip 11/1/2015 No N/A N/A Rue Michel-Servet 1-1211 Geneve 4 of the brain stem The integrity of synaptic transmission in this nucleus matures postnatally We have collected Geneva 1206, Switzerland preliminary data that suggest that SHank3, a protein deficient in the Phelan-McDermit syndrome, is required for the normal maturation of these synapses We therefore propose to test the hypothesis that impaired Shank3 function leads to impaired maturation, deficient synaptic transmission and eventually impaired social interactions Our pilot study may provide a proof of principle for the involvement of altered synaptic function in the reward circuit as a mechanism underlying disturbed social interaction in ASD THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED ) GRANTEE University of Lausanne 100,000 11/30/2013 84,005 Copy number variants (CNVs) are major contributors to neurodevelopmental and psychiatric disorders The 600kb- 11/1/2014, No N/A N/A Service Financier long 16p11 2 deletion that encodes 29 annotated protein-coding genes and its reciprocal duplication are amongst (11/1/2015) the most frequent causes of neurodevelopmental disorders with population prevalence of 1/2000 each These recurrent rearrangements are associated with reciprocal phenotypes such as obesity and underweight, macro- and microcephaly, autism spectrum disorder (ASD) and schizophrenia (SCZ), as well as various forms of epilepsy These comorbidities might be causally linked, with macrocephaly shown to be associated with ASD and microcephaly with SCZ for example Consistent with these observations we report an increased growth velocity of the head circumference during 16pll 2 deletion patients' infancy, which recapitulates the well-documented pattern in idiopathic ASD The reciprocal 16pll 2 CNVs represent a powerful tool to investigate pathways involved in obesity and neuropsychiatric disorders

The first goal of the proposed research is to better define these clinical entities in humans and understand how the 16p11 2 variants in combination with additional factors lead to different clinical outcomes The second objective is to use our engineered mouse models to test candidate genes and explore the pathophysiology of these CN Vs Our results should bring new insights in these diseases, information on genes underlying these conditions and pathways leading to morbidity, thereby providing potential targets for better patient management and care or treatment

University of Lausanne 100,000 11/30/2014 Copy number variants (CNVs) are major contributors to neurodevelopmental and psychiatric disorders The 600kb- (11/1/2015) No N/A N/A Service Financier long 16p11 2 deletion that encodes 29 annotated protein-coding genes and its reciprocal duplication are amongst the most frequent causes of neurodevelopmental disorders with population prevalence of 1/2000 each These recurrent rearrangements are associated with reciprocal phenotypes such as obesity and underweight, macro- and microcephaly, autism spectrum disorder (ASD) and schizophrenia (SCZ), as well as various forms of epilepsy These comorbidities might be causally linked, with macrocephaly shown to be associated with ASD and microcephaly with SCZ for example Consistent with these observations we report an increased growth velocity of the head circumference during 16pll 2 deletion patients' infancy, which recapitulates the well-documented pattern in idiopathic ASD The reciprocal 16pll 2 CNVs represent a powerful tool to investigate pathways involved in obesity and neuropsychiatric disorders

The first goal of the proposed research is to better define these clinical entities in humans and understand how the 16p11 2 variants in combination with additional factors lead to different clinical outcomes The second objective is to use our engineered mouse models to test candidate genes and explore the pathophysiology of these CN Vs Our results should bring new insights in these diseases, information on genes underlying these conditions and pathways leading to morbidity, thereby providing potential targets for better patient management and care or treatment THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT'S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE University of Toronto 164,853 3/31/2013, 164,853 Duplication of a small segment of human chromosome 7 has recently been found in some children with autism 3/1/2014, No N/A N/A 7360 Medical Sciences Building 9/30/2013 This project aims to understand the underlying biology of autism in this group through the study of a mouse model 3/1/2015 1 King's College Circle with a similar duplication, and the study of human brain cells (neurons) made from the blood cells of people with Toronto, ON M55 1A8, Canada the duplication The duplication mouse model will undergo in-depth testing for behaviors that are relevant to autism in humans, such as abnormal social interaction, impaired communication and repetitive behaviors We will also use MRI imaging to look at the brain structure in these mice, and examine how their neurons grow and function in culture, with the aim of seeing whether they show similar or different alterations to other mouse models of autism We will use a recently developed technique to reprogram human blood cells into stem cells, and then make these stem cells grow into neurons in culture This technique lets us study neurons from people with the chromosome 7 duplication and unaffected family members, even though we cannot access brain tissue directly We will carry out parallel studies of the growth and function of these neurons and compare the results to those from the mouse model Finally, we will look at all the genes in these mouse and human neurons, to see whether we can find any differences in which genes are switched on or off in cells with the duplication, compared to cells without the duplication Together, these experiments will provide key information about the effect of the chromosome 7 duplication on the growth and function of the brain This study will contribute to the growing understanding of the biology of autism and help build a picture of how and why symptoms arise in autism due to alterations in different genes

University of Toronto 164,326 3/30/2014, 151,168 Duplication of a small segment of human chromosome 7 has recently been found in some children with autism 3/1/2014, No N/A N/A 7360 Medical Sciences Building 9/30/2014 This project aims to understand the underlying biology of autism in this group through the study of a mouse model 3/1/2015 1 King's College Circle with a similar duplication, and the study of human brain cells (neurons) made from the blood cells of people with Toronto, ON M55 1A8, Canada the duplication The duplication mouse model will undergo in-depth testing for behaviors that are relevant to autism in humans, such as abnormal social interaction, impaired communication and repetitive behaviors We will also use MRI imaging to look at the brain structure in these mice, and examine how their neurons grow and function in culture, with the aim of seeing whether they show similar or different alterations to other mouse models of autism We will use a recently developed technique to reprogram human blood cells into stem cells, and then make these stem cells grow into neurons in culture This technique lets us study neurons from people with the chromosome 7 duplication and unaffected family members, even though we cannot access brain tissue directly We will carry out parallel studies of the growth and function of these neurons and compare the results to those from the mouse model Finally, we will look at all the genes in these mouse and human neurons, to see whether we can find any differences in which genes are switched on or off in cells with the duplication, compared to cells without the duplication Together, these experiments will provide key information about the effect of the chromosome 7 duplication on the growth and function of the brain This study will contribute to the growing understanding of the biology of autism and help build a picture of how and why symptoms arise in autism due to alterations in different genes THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE Weizmann Institute of Science 125,000 5/30/2013, 125,000 Our brain is comprised of an intricately connected network of neural circuits individual circuits are charged with 11/1/2014 No N/A N/A 234 Herzl Street 11/30/2013 performing certain functions, from interpreting visual signals to orchestrating complex motions and regulating Rehovot 76100, Israel emotion Within each circuit, the individual neurons which together make up the circuit are also connected in ways that are partly dictated by genetics but are also continually modified based on individual experience The connections between neurons are called synapses At synapses, neurotransmitters are released when a neuron is activated Neurotransmitter release events are detected by post-synaptic (downstream) neurons, ultimately leading to activation and neurotransmission to the next order neurons In the cortex, the outer shell of the brain, recurrent connectivity within small regions called microcircuits leads to the reverberation of activity following activation of a small population of neurons This recurrent activity involves the activity of both excitatory neurons (which activate downstream cells) and inhibitory neurons (which inhibit the activity of downstream cells) The balance between the activity of these two neuron populations therefore has dramatic influences on the way in which cortical circuits process information Changes in the balance between cortical excitation and inhibition have been associated with diseases such as autism, schizophrenia and epilepsy We propose that lasting changes in the activity of excitatory or inhibitory neurons can lead to dramatic remodeling of the brain, and culminate in altered connectivity To test this hypothesis, we will employ state-of-the-art optogenetic optogenetic methods combined with electrophysiological and optical detection of neuronal activity This will allow us to decipher network connectivity in wild-type and autism model mice We will then test whether direct manipulation of the cortical circuit in vivo can lead to changes in connectivity both in normal animals and autism models, laying out a theoretical framework for future therapies

Weizmann Institute of Science 62,500 5/30/2014 62,500 Our brain is comprised of an intricately connected network of neural circuits individual circuits are charged with 11/1/2015 No N/A N/A 234 Herzl Street performing certain functions, from interpreting visual signals to orchestrating complex motions and regulating Rehovot 76100, Israel emotion Within each circuit, the individual neurons which together make up the circuit are also connected in ways that are partly dictated by genetics but are also continually modified based on individual experience The connections between neurons are called synapses At synapses, neurotransmitters are released when a neuron is activated Neurotransmitter release events are detected by post-synaptic (downstream) neurons, ultimately leading to activation and neurotransmission to the next order neurons In the cortex, the outer shell of the brain, recurrent connectivity within small regions called microcircuits leads to the reverberation of activity following activation of a small population of neurons This recurrent activity involves the activity of both excitatory neurons (which activate downstream cells) and inhibitory neurons (which inhibit the activity of downstream cells) The balance between the activity of these two neuron populations therefore has dramatic influences on the way in which cortical circuits process information Changes in the balance between cortical excitation and inhibition have been associated with diseases such as autism, schizophrenia and epilepsy We propose that lasting changes in the activity of excitatory or inhibitory neurons can lead to dramatic remodeling of the brain, and culminate in altered connectivity To test this hypothesis, we will employ state-of-the-art optogenetic optogenetic methods combined with electrophysiological and optical detection of neuronal activity This will allow us to decipher network connectivity in wild-type and autism model mice We will then test whether direct manipulation of the cortical circuit in vivo can lead to changes in connectivity both in normal animals and autism models, laying out a theoretical framework for future therapies THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE Weizmann Institute of Science 62,500 5/30/2014 62,500 Autism spectrum disorder (ASD) encompasses a range of cognitive and behavioral phenotypes Recent studies 11/1/2014 No N/A N/A 234 Herzl Street suggest that particular abnormalities in gene expression and splicing are common in individuals with ASD A major Rehovot 76100, Israel challenge is to link these molecular abnormalities with ASD-associated behaviors in this proposal, we chose to focus on the autism-implicated gene A2BP1 (also known as RBFOX1), which encodes a protein which is involved in regulating a gene-editing process known as alternative splicing in this process some of the elements in the protein- making sequence encoded in a gene, termed exons, can be "cut and pasted" to make slightly different gene products, termed splice variants Lower expression of A2BP1 in autistic brains was shown to be associated with dysregulated splicing of A2BP1 target exons We have recently shown that the alternative splicing of one such A2BP1 target - a receptor called PAC1 is implicated in activation and termination of the animal's stress and anxiety- like responses By studying the regulation of A2BP1 levels and the roles of PAC1 splice variants in stress/anxiety-like behaviors, we propose to follow-up on these new findings in an effort to understand the mechanisms linking A2BP1 mediated splicing and behavior As anxiety is common in ASD, we expect that the principal mechanisms that will be revealed through this study will shed light on the physiological link between A2BP1 and its targets This may prove to be relevant to the molecular events that contribute to ASD

Erwin Schrodinger International 110,000 3/2/2201 110,000 Simons Junior Professor in Mathematics or Mathematical Physics 4/30/2015 No N/A N/A Institute for Mathematical Ph ysics CNRS Regional Delegation Languedoc- 80,000 1/30/2014 72,764 In the course of the Origin of Life process, the main features of living organisms emerged and most importantly the 12/31/2014 No N/A N/A Roussillon ability to evolve according to Darwinian theory Using the Systems Chemistry approach, we seek to identify Route de Mende n 1919 pathways leading to self-organization in chemical systems We will investigate the potential role of chemically Montpellier 34293, cedex 5, France activated amino acid and peptide derivatives through their reactions with ribonucleotides and RNA and possibly in , facilitatin g the re p lication p rocess Medical Research Council Library of 81,000 1/30/2014 77,235 One of the fundamental traits of life is self replication Therefore the emergence of self-replication is closely linked 12/31/2014 No N/A N/A Molecular Biology to life's origin itself Several strands of compelling evidence strongly suggest that our current biology, which relies Francis Crick Avenue on DNA for information storage and proteins for catalysis, was preceded by a primordial biology that instead relied Cambridge Biomedical Campus on DNA close chemical cousin RNA for both heredity and metabolism It is therefore widely believed that this Cambridge CB2 OQH, United Kingdom ancestral biology, also referred to as the 'RNA world' began with an RNA molecule that acquired a capacity for self- replication and mutation and hence evolution towards ever more efficient self-replication Unfortunately, this primordial replicase appears to have been lost However, we can reconstruct modern analogues and study the properties of these molecular 'Dopplegangers' in order to better understand life's first genetic system Furthermore, using methods of evolution in the laboratory we can retrace the first steps this ancestral molecule must have taken and ultimately reconstruct an RNA world in the test-tube

Funda45o D Anna de Sommer 182,254 3/30/2014, 174,327 Learning to automatize actions and form habits is critical for mastering every day skills and activities such as riding a 3/1/2015 No N/A N/A Champalimaud e Dr Carlos Montez 9/30/2014 bike, speaking or writing However, if automatized actions and habits are too strong, this can lead to an Champalimaud overabundance of stereotyped, repetitive behaviors and to lack of control or ability to switch to novel behavioral Av Brasilia patterns Patients with Autism Spectrum Disorders (ASD) demonstrate impaired habit learning and repetitive 1400-038 Lisboa, Portugal behaviors The neural circuits underlying these behaviors, however, remain unclear The dorsolateral striatum, a region of the basal ganglia, has been implicated in habit formation and repetitive behavior However, the link between dysfunction of this structure and ASD-related repetitive behavior remains elusive Interestingly, the striatum, the major input structure of the basal ganglia, is a complex structure with several subcircuits, including a 'direct pathway' to the output nuclei (striatonigral) and an 'indirect pathway' to the output nuclei (striatopallidal) thought to facilitate or inhibit movement, respectively in this proposal, we will directly assess the relationship between repetitive behaviors and habit formation in mice with deletions in the ASD-associated genes, CNTNAP2 and Shank3 We will then image striatal circuit dynamics in these mice using a miniature microscope and a genetically encoded calcium indicator to visualize neuronal activity during their stereotyped, repetitive grooming and habit formation Finally, we will directly determine if manipulating either direct or indirect pathway function by activating or inhibiting their activity during repetitive behaviors and habit formation can ameliorate or exacerbate the behavioral symptoms Using these approaches, we hope to identify the striatal neuronal pathway dysfunction mediating these behaviors determined as core ASD symptoms THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE University of Yaounde 1 7,000 9/30/2014 4,890 Africa Collaboration Grant 10/31/2014 No N/A N/A Avenue J F Kennedy PO Box 700 Centre Yaounde-Cameroon The Governors of the University of 52,224 11/30/2014 Children with the genetic disorder Prader-Wilk syndrome have a very high rate of autism spectrum disorders, along (11/1/2015) No N/A N/A Alberta with neonatal feeding difficulties, developmental delay, endocrine dysfunction and obesity Prader-Wilk syndrome Attn Research Accounts Receivables occurs in about 1 15,000 births and is caused by the deletion of part of a chromosome containing a group of genes 3rd Floor Administration Building One of these genes is called MAGEL2 Recently, a small number of children with autism were found to have genetic Edmonton, Alberta T6G 2M7, Canada mutations that also inactivate MAGEL2 These children also have some but not all features of Prader-Wilk syndrome, but do not have the other PWS genes inactivated We know that the protein that the MAGEL2 gene produces is important for the modification and destruction of other proteins MAGEL2 does this by assisting other proteins, called ubiquitin ligases We now want to find out more about the MAGEL2 protein, including what it normally does inside the cell, and what other proteins it interacts with Specifically, we will test whether MAGEL2 interacts with ubiquitin ligases that are involved in other neurodevelopmental disorders including autism Our study will place the MAGEL2 protein into the network of proteins and processes already implicated in autism

University of Toronto 129,600 7/1/2014 129,600 The main scientific goals are extending cylinder renormalization to dissipative maps in two dimensions, to describe 2/28/2015 No N/A N/A 12 Queen's Park Crescent West, 3rd FI the geometry of attractors of dissipative maps of the cylinder and boundaries of Siegel cylinders of dissipative Toronto, Ontario M5S 1S8, Canada Henon maps, studying the question of computational complexity of a typical rational Julia set, studying geometrization of Thurston ma p s and decidabilit y of Thurston e q uivalence McGill University 97,325 9/1/2014 97,325 Solving thermal QCD using String Theory techniques 10/31/2015 No N/A N/A Research Financial Management Services 3465 Durocher Street , 3rd Floor University of Oxford 60,476 11/30/2014 The proposed research takes advantage of the substantial resources available within Oxford University to (11/1/2015) No N/A N/A 23-38 Hythe Bridge Street demonstrate a new MRI marker of autism Disturbed development of microscopic brain cell structures, called Oxford, OX1 2ET UK 'minicolumns', has come to form one of the key theories of what is different in the brain in ASD These minicolumns have also been suggested to explain greater sensory sensitivity in autism and as a target for therapies However, accurate diagnosis in life is difficult because detailed developmental changes in these structures cannot be seen in brain imaging of living subjects Our goal is to prove that a signal for this microscopic structure may now be detected and measured in MRI scans of post-mortem tissue This measure has enormous potential for future application in living subjects if proven, it would aid early diagnosis and provide a harmless and reliable method to monitor ongoing changes across the lifespan, including changes in response to therapies Ultimately, it would help to improve individual care through more effective, targeted therapies We have previously pioneered work that demonstrated the relationship between brain minicolumns and mental ability, including IQ Identifying changes in the brain areas that process sound, vision and other senses also has great promise for developing simple, sensory, diagnostic tests The study will take measurements in human brain tissue from 15 ASD and 15 typically developed comparison subjects from the UK brain bank which has strong links to the USA program These will be directly compared with ground-breaking analysis of MRI scans from exactly the same brains, as well as piloting such measures in pre-existing living brain scans from 46 subjects Several brain regions will be examined including those related to primary senses (vision and sound), Theory of Mind, language and planning THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE Research Center of Centre hospitaher 59,834 5/30/2014 36,583 Autism spectrum disorders (ASDs) comprise a range of developmental disorders resulting in abnormal social 7/1/2015 No N/A N/A de I'Universite de Montreal behaviour, difficulty communicating, and stereotyped & repetitive behaviour Recent scientific advances have 900, rue St-Denis begun to decipher the genetic mechanisms driving ASDs With these discoveries comes the possibility of developing Tour Viger, Office R03 408 new therapeutic approaches Since many of the genes linked to ASDs are conserved throughout evolution we Montreal, Quebec, Canada H2X 0A9 propose to use simple genetic models of ASDs to identify new therapeutics The simple animal model C elegans has homologues of many genes linked to ASDs, and these mutant strains show neuronal dysfunction leading to movement problems We will test a library of FDA-approved drugs to find molecules that restore normal neuronal behaviors in our C elegans models for ASDs These molecules may have clinical relevance and could aid further drug discovery and development for ASD patients

Fondazione Istituto Italiano di 55,260 6/30/2014 55,260 Human brain function is the result of a highly organized network of connections linking multiple areas across the 9/1/2015 No N/A N/A Tecnologia brain A common theory to explain autism is that genetic information interacting with environmental factors leads Via Morego to impaired or deranged communication between these unique brain areas While the' underconnectivity' theory 30 16163 Genova (GE), Italy of autism is considered one of the best-supported theories for the neural basis of the disorder, several crucial questions still remain unanswered For one, the hypo-connectivity phenomenon is highly heterogeneous among individuals with autism, and may even occur in reverse form (i e , hyper-connectivity) during early development Moreover, the contribution of genetic alterations to the connectional derangements observed in autism is largely unknown, and it is also unclear whether these abnormalities are a cause or a consequence of the disorder Mapping brain connectivity in mouse models recapitulating genetic alterations associated to autism can be instrumental in providing an answer to these questions Capitalizing on our experience in the application of functional Magnetic Resonance Imaging (fMRI) in the mouse, we recently described for the first time the possibility to map brain connectivity networks in this species We propose to use fMRI to map brain connectivity in mouse models bearing autism-relevant genetic deficits The use of an imaging technique widely used in clinical research will offer the unprecedented opportunity to directly compare analogous readouts in man and mice, and will provide proof-of-concept for using our mouse-imaging platform to study the contribution of autism-related genes to the connectivity derangements observed in patient populations

King's College London 60,000 4/30/2014 60,000 The identification last year of a high-risk autism gene called CHD8 provides a unique opportunity to better 6/1/2015 No N/A N/A Strand understand the causes of autism We need to understand what this autism-associated gene normally does in London, WC2R 2LS developing brain cells in order for us to understand how changes in CHD8 function affect brain development and hence cause autism This knowledge may provide opportunities for interventions to compensate for loss of function effects The use of mouse models and patient-derived cells are powerful, but time-consuming approaches Whilst we work on establishing these models to study CHD8 function, we have developed a new zebrafish model that will allow us to make rapid progress in identifying how CHD8 controls brain development We will use this new system to test if and how CHD8 controls three potential processes linked to autism 1) an important pathway called WNT that is essential for several aspects of brain development, 2) a process called transcriptional elongation that is important for the production of key molecules that controls brain development and often abnormal in autism and 3) a mechanism used to switch genes off, called histone deacetylation We already have evidence from our studies in zebrafish and laboratory cell lines that CHD8 might regulate all three these processes Finding solid evidence that CHD8 controls these processes during brain development will allow us to make much better use of more sophisticated models like mice and human neurons in the future Furthermore, zebrafish embryos are ideal for large-scale drug screening approaches, which will allow us to screen for potential drugs that can prevent some of the detrimental effects of CHD8 mutation

ICTP South American Institute for 60,000 10/1/2014 38,471 Sao Paulo State Research Funding Agency Fellowship 10/31/2015 No N/A N/A Fundamental Research Avenida Rio Branco 1210 - Campos Eliseos Sao Paulo , SP - CEP 01206-001 Centre de Recerca Matematica 55,000 7/1/2014 51,550 Simons Visiting Program aimed at enhancing the participation of senior researchers in the CRM Intensive Research 8/31/2015 No N/A N/A Via Laietana 2 Programmes 08003, Barcelona THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION (RETURNED) GRANTEE University College London 100,002 8/30/2014 100,002 Nature has built all living species from a small set of universal chemical components The universality of these 8/1/2015 No N/A N/A Gower Street biochemical components first led to the idea of a chemical origin of life Organic chemistry was born from the London, WC1E 6BT desire to understand the chemical constituents of life and, as early as 1828, the synthesis of the organic molecule urea from inorganic materials was reported However, understanding the origins of life, and transition from inanimate to animate, remains one of the most fundamental and diverse challenges to face modern science Inevitably, chemistry must play a significant role in elucidation of the pathways through which molecules can give rise to life Although life consists of an intriguingly small constellation of closely related molecules, the function of the individual biological molecules cannot be appreciated in isolation Therefore, we propose that the generation of the first biological molecules, at the origins of life, requires unified investigation We will use chemistry to explore the fundamental links between the essential molecular components of biology

Perimeter Institute for Theoretical 167,000 5/1/2014, 67,997 Simons Collaboration on the Many Electron Problem - PI, Tensor Networks Group 4/30/2015 No N/A N/A Physics 9/1/2014 31 Caroline Street North King's College London 300,000 5/1/2014, 153,498 Simons Collaboration on the Many Electron Problem - Director, Real Materials Group 4/30/2015 No N/A N/A MRC Centre for Developmental 9/1/2014 Neurobiology 4th Floor, New Hunt's House Guy's Campus London SE1 1UL King's College London 150,000 5/1/2014, 59,246 Simons Collaboration on the Many Electron Problem - PI, Real Materials Group 4/30/2015 No N/A N/A MRC Centre for Developmental 9/1/2014 Neurobiology 4th Floor, New Hunt's House Guy's Campus London SE1 1UL University College London 97,230 9/30/2014 97,230 Much like a digital computer constructs sophisticated computations from the action of simple switches, the brain as 9/1/2015 No N/A N/A Gower Street a whole is able to execute vastly more complex computations than can any one of its component elements In both London, WC1E 6BT systems, this remarkable computational power hinges on fine coordination between the simple parts, as they function within their respective circuits However, though we understand both switches and circuits in a computer, we have only the most rudimentary idea of how such coordinated computation is achieved within the brain The components of the brain - the nerve cells or neurons - mostly send signals to each other in the form of sequences of short pulses or "spikes" To the best of our current knowledge, these spikes are generated and transmitted in a stochastic way, leading to the current belief that the brain must overcome this "noise" to compute Much of what we have learned about computation in the brain has been based on experiments that listen to spikes from one neuron at a time, averaging over experiments to beat down the noise Increasingly, however, technical advances make it possible to measure spikes simultaneously from hundreds or thousands of neurons within a single circuit Butjust to measure the spikes is not, by itself, to understand the computation To do that we must discover the ways in which the neurons are coordinated, and how that coordination effects the computation Our goal in this project is to develop the algorithms and data-analytic tools that will be needed to achieve this objective We will seek to detect the patterns and regularities in the spikes produced by many cells working together By identifying such concerted action we believe we will be able to see through the noise (much as the brain itself does) to the computation that unfolds moment by moment

Neurochlore 5,000 4/30/2014 5,000 Brain development and disorders EMBO Conference 11/1/2014 No N/A N/A Institut de Neurobiologie de la Mediterranee 163 route de Lumm y Ecole Polytechnique 150,000 8/1/2014, 60,570 Simons Collaboration on the Many Electron Problem - Cluster Embedding Group 10/31/2015 No N/A N/A Route de Saclay 9/1/2014 91128 Palaiseau cedex, France THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/( DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED ) GRANTEE IMP Research Institute of Molecular 56,080 9/30/2014 56,080 In the human brain, billions of networked neurons sense the environment, process, store, and retrieve information, 9/1/2015 No N/A N/A Pathology GmbH and produce thoughts and behavior on a continuous basis A major program of neuroscience today is to attempt to Dr Bohr-Gasse 7 understand the mechanism behind these cognitive processes by mapping in detail the brain anatomy of model 1030 Vienna, Austria organisms such as mice and fruit flies These efforts are challenged by the sheer numerical complexity of neuronal wiring found even in these small animals We currently lack a framework to interpret these vast anatomical data This is exemplified by the fact that the nervous system of the small soil worm C elegans, which has only 302 neurons, was mapped in exquisite anatomical detail 25 years ago, yet it is still largely unknown how this brain produces competent, ongoing behavior One principle neuroscientists largely agree on it is the collective dynamical activity of internetworked neurons that produces thoughts and behavior in real time However, the relationship between this activity and the network structure upon which it plays out on is a huge unknown

Our lab has developed a new microscopy technology that can, for the first time, capture the real time activity of an entire brain at single-cell resolution We will use this platform, coupled with a novel experimental approach to arouse worms with complex, varied stimuli and computational methods for distilling functional relationships from network-wide activity data, to unravel the relationship between the connectome and dynamics in the worm brain

The function-from-structure question is of fundamental significance to the brain mapping efforts underway in more complex organisms, our work in the worm will establish a baseline of how useful a connectome can be for elucidating the neural mechanisms of thought We thus will discover general principles of how function arises from brain architecture

Funda45o D Anna de Sommer 122,311 9/30/2014 122,311 Uncertainty is a paramount issue for diverse aspects of cognition Even given perfect noiseless sensory data, if an 9/1/2015 No N/A N/A Champalimaud e Dr Carlos Montez agent's model of the causal structure of the world is imperfect, there will exist uncertainty about which outcomes Champalimaud will result from specific actions, or "policy uncertainty" For instance, when you leave your home you need to Av Brasilia decide what type of packet to wear Looking at the sky or checking the forecast can help you predict the weather for 1400-038 Lisboa, Portugal the rest of the day but this prediction will be subject to uncertainty, which is turn implies uncertainty in your policy on what to wear In this proposal, we will investigate the brain systems involved in processing policy uncertainty in the context of decision-making We will address two questions (I) How is policy uncertainty associated with different actions encoded in brain areas responsible for action selection? (II) How is policy uncertainty decoded in order to form estimates of outcome probabilities, as is crucial for reporting decision confidence? We hypothesize that in premotor cortical areas, the identity of candidate actions and their associated uncertainties are intermingled We then look in the reciprocally connected orbitofrontal cortex (OFC) to assess how action uncertainty is decoded to inform outcome predictions The work will help to addresses the critical issues of how policy uncertainty is encoded and decoded by neuronal populations The experiments on premotor cortex will test alternative coding hypotheses and reveal whether uncertainty coding varies within different layers of a cortical circuit The experiments will reveal how implicit representations of uncertainty can be read out, possibly revealing new generic algorithms for so-called metacognitive processes that are a hallmark of higher cognition

Fundacao D Anna de Sommer 50,510 9/30/2014 50,510 The role of the basal ganglia in goal-directed movement behavior A wealth of data indicates that this collection of 9/1/2015 No N/A N/A Champalimaud e Dr Carlos Montez subcortical nuclei is important for movement, for example, basal ganglia diseases cause profound movement Champalimaud disorders (e g , Parkinson's) The basal ganglia (BG) receives inputs from nearly the entire cortical mantle including Av Brasilia numerous motor areas, and principally influence behavior not through projections to the spinal cord, but rather 1400-038 Lisboa, Portugal through projections back to the very cortical areas from which they receive inputs Our core hypothesis is that a major function of the basal ganglia is to bias cortical activity towards states for generating actions associated with positive reinforcement Borrowing a useful analogy, outputs of the BG are forcing functions acting on cortical activity We elaborate below how recent dynamical systems approaches to motor cortical function are highly relevant for thinking about how the BG contributes to goal-directed behavior, and also allow us to transform the notion of the BG as a forcing function from abstract analogy into concrete testability THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE University College London 114,882 9/30/2014 114,882 The cerebral cortex is thought to process information through local circuits involving nearby neurons However, 9/1/2015 No N/A N/A Gower Street these local computations are influenced by global variables such as brain states, which reflect factors such as London, WC1E 6BT wakefulness, behavior, motivation, attention, and alertness These interactions are currently poorly understood

First, how global are brain states? When the brain is at rest, the cortex is in a global state characterized by slow spontaneous traveling waves We hypothesize that the use of a local region of cortex excludes this region from those traveling waves We will test this hypothesis by imaging global patterns of cortical activity, as mice transition from rest to an active visual discrimination task, and back to subsequent rest

Second, how do brain states affect local computation? We hypothesize that the local effect of brain state is to control neuronal responsiveness, and that this effect is multiplicative Further, we hypothesize that the local effects of brain state are more strongly felt in areas that are closer to motor output than to sensory input We will test these hypotheses by imaging local groups of "1,000 neurons, and comparing their responsiveness during visually demanding tasks vs during passive viewing

Third, how does a neuron combine local activity with global modulations? Preliminary observations suggest a striking difference between signals measured at the soma vs apical dendrites The former seem to reflect mostly the sensory inputs, whereas the latter seem to reflect mostly top-down influences if confirmed, this observation suggests that distal dendrites are the emissaries to the soma of global brain signals We will test this hypothesis by imaging single neurons, and comparing the responses of their dendrites to those at the soma

This research will reveal how global activity patterns are structured at a systems level, and how they affect local neuronal populations and individual neurons

Ludwig-Maximilians-Universitaet 143,500 9/30/2014 143,500 We aim to create experimental living systems bottom up in the lab We hope to implement Darwinian evolution 9/1/2015 No N/A N/A Geschwister-Scholl-Platz 1 with very basic building blocks driven by nonequilibrium conditions As a result, we hope to overcome central 80539 Munich, Germany logical hurdles in our present understanding of the origins of life We will start from prebiotically plausible conditions with low concentrations of simple molecular building blocks Various microscopic nonequilibria will be explored In the past, we focused on temperature differences across pores of rock While a temperature gradient is a very basic non-equilibrium condition, it can tackle a number of central problems We showed that a thermal gradient can trigger exponential replication by convection, separating genetic molecules exponentially accumulate even small molecules towards the pore bottom accumulate longer and more complex molecular assemblies exponentially better escalate polymerization towards long ohgonucleotides at the same time accumulate and replicate DNA with the help of an enzyme The challenges are multifold For non-equilibrium conditions to be fast and effective, they have to be implemented at the size scales of life in this micrometer regime, analytical methods become demanding when experimental volumes are limited to the low nanoliter range Because of our good experiences with molecular non-equilibrium systems and their novelty in experimental origin of life scenatros, this route less traveled should be a rewarding THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED / PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE The University of Cambridge 200,280 9/30/2014 2,030 After two decades of discoveries, planets orbiting other stars (exoplanets) capture the interest of both scientists 9/1/2015 No N/A N/A The Old Schools and the public with the haunting prospect of the search for life in the Universe Beyond the exploration of the Trinity Lane architecture of planetary systems that have revealed surprising diversities, exoplanets bulk structure and Cambridge CB2 1TN, United Kingdom atmosphere compositions holds key insights into their origins and history as well as long-term prospect to remotely question the potential habitability of these "other worlds" While its seems an extraordinary endeavor, only a handful of key ingredients are required to start characterizing an exoplanet in light of what we have learnt for Solar System planets with the prospect to look for bio- signature detections The fundamental quantity includes, the mass and the size of the planet, its temperature and some physical characteristic of major chemical ingredients present in its atmosphere These fundamental parameters allow us to gather insights on the composition, formation and evolution history of planets, eventually bringing new elements to question their habitability and the diversity of physical conditions where life may develop The special geometry of transiting planets provides us with an efficient and realistic way to probe their atmospheric structure During the secondary eclipse, the star occults the thermal emission from the planet, which can then be computed from comparison with the total flux out of transit With measurements at several wavelengths, we can map the spectral energy distribution The observation of the planet during the transit at many different wavelengths allows us to obtain its transmission spectra (stellar light going through the planet atmosphere) With these observations, atmosphere properties such as albedo, thermal redistribution efficiency temperature structure and composition of the atmosphere may be retrieved The nearest ultra-cool stars offers us a unique opportunity to search for life signature These stars, the most frequent in our Galaxy, are typically two times cooler than the Sun, and their sizes are similar to Jupiter The habitable zone region is 30-100 times closer than for the Sun and transit signature of an Earth size planet in orbit would be deep and short enough to be detected from the ground We proposed a new facility (SPECULOOS) to carry out a survey of ultra cool stars almost uniformly spread in the whole sky The outcome of this survey will be an unique set of small "Earth like" transiting planet for which structure and physical conditions of their atmosphere can be characterised with a facility like JWST with the

McGill University 66,000 8/1/2014 51,006 Simons Investigator in the Mathematical Modeling of Living Systems 9/30/2015 No N/A N/A Rutherford Physics Building 3600 Rue University Montreal, QC H3A 2T8, Canada University of Zurich 99,752 11/30/2014 99,752 Almost every aspect of cognition emerges from a rapid, free-flowing succession of highly structured patterns of (11/1/2015) No N/A N/A Winterthurerstrasse 190 neural activity maintained by large populations of neurons across many brain areas in most circumstances of CH-8057 Zurich, Switzerland everyday life, it is rare for the brain to dwell in the same state for more than a fraction of a second, and yet, mainly because of technical limitations, much of cognitive neuroscience has arguably dealt with studying 'snapshots' of brain activity As a consequence, we have accumulated a wealth of knowledge about what the responses of individual neurons or brain areas represent (e g orientation, faces, goals), but still mostly lack an understanding of how these responses relate and contribute to the inherently dynamic computations performed collectively by large networks of neurons In this project we hope to contribute to changing this state of affairs We will exploit recent technical advances to record neural activity from the large number of neurons necessary to observe how the 'state' of the neural dynamics evolves from one instant to the next We will characterize the dynamics of responses in prefrontal cortex, a brain area largely unique to primates that underlies our pronounced ability to flexibly choose among possible actions in response to ever-changing circumstances Our goal is to develop a mechanistic model that can reproduce and explain how the neural dynamics observed in prefrontal cortex is controlled by contextual information, and how this dynamics ultimately leads to flexible decisions To validate the model, we will elicit small, almost imperceptible, "perturbations" of prefrontal activity, and compare their neural and behavioral effects to those predicted by the model This quantitative approach will lead to a deeper understanding of prefrontal computations, and will contribute to finally achieving a mechanistic understanding of cognition THE SIMONS FOUNDATION INC 2014 FORM 990-PF STATEMENT 18 13-3794889 PART VII-B LINE SC EXPENDITURE RESPONSIBILITY STATEMENT

AMOUNT DATE/(DUE) OF GRANT DATE OF DIVERSIONS VERIFICATION RESULTS OF RECIPIENT ' S NAME AND ADDRESS EXPENDED/ PURPOSE OF GRANT REPORTS BY AMOUNT GRANT BY GRANTEE DATE VERIFICATION ( RETURNED) GRANTEE The University of Queensland 60,000 10/29/2014 Past work has made it clear that there are important links between Autism Spectrum Disorder (ASD) and the (1/1/2016) No N/A N/A Brisbane QLD 4072, Australia cerebellum, but it is still poorly understood exactly what goes wrong as the cerebellum develops, and how these problems result in the behavioral issues encountered by ASD sufferers In this project, we are using a new set of optogenetic techniques to look at how individual cells in the cerebellum develop and function Because we will be working in zebrafish, an optically clear organism, we will be able to see how cerebellar cells develop over time We do this both for genetically normal animals and animals bearing mutations associated with ASD The goal is to figure out what the impacts of these genetic mutations are on the development of cerebellar circuits, and therefore to better understand the links among genes, cells, circuits, and behavior in ASD

National Centre for Biological Sciences 200,000 7/1/2013, 116,468 Simons Center for the Study of Living Machines 8/31/2014, No N/A N/A GKVK Post, Bellary Road 12/31/2013 8/31/2015 Ban galore 560065, India National Centre for Biological Sciences 100,000 7/1/2014 0 Simons Center for the Study of Living Machines 8/31/2015, No N/A N/A GKVK Post, Bellary Road (8/31/2016) Ban galore 560065, India University of Geneva 38,520 9/30/2014 38,520 Neural encoding and decoding of policy uncertainty in the frontal cortex 9/1/2015 No N/A N/A 1 rue Michel-Servet 1211 Geneva 4, Switzerland Institut National de la Sante et de la 49,485 12/31/2014 How the basal ganglia forces cortex to do what it wants (12/1/2015) No N/A N/A Recherche Medicale Inserm Dr Paris 6 127 Avenue Ledru Rollin 75011 Paris , France The Simons Foundation EIN#: 13-3794889 Form 990-PF FYE: 12/31/2014

Form 990-PF , Part IX-A Summary of Direct Charitable Activities

1. The Simons Foundation Autism Research Initiative seeks to improve understanding, diagnosis and treatment of autism spectrum disorders by funding innovative scientific research. It also provides support to other organizations with allied goals and holds conferences , lectures & meetings to further scientific understanding of autism.

2. The Simons Center for Data Analysis advances scientific research by creating new mathematical, statistical and computational tools to help scientists analyze large data sets.

3. The Mathematics and Physical Sciences Division supports basic science in the areas of mathematics, theoretical computer science and theoretical physics by supporting researchers in those areas and by organizing conferences, meetings, lectures and symposia on relevant topics.

4. The Life Sciences Division supports basic research in the life sciences and organizes collaborations for deeper understanding of the processes that led to the emergence of life in the universe; the use of new technologies for neural coding ; and the biology, ecology, and biogeochemistry of microbial processes.

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