Count 0 10000 20000 30000 40000 −6 −4 −2 and Histogram Color Key V alue 0 Figure S1. Heat map of DEGs between lowand overexpression PVT1 groups. 2 4 6

TCGA−DX−AB2E−01A−11R−A39D−07 TCGA−X6−A8C4−01A−11R−A36F−07 TCGA−DX−A6YX−01A−11R−A41I−07 TCGA−3R−A8YX−01A−11R−A37L−07 TCGA−DX−AB2X−01A−11R−A38C−07 TCGA−WK−A8Y0−01A−11R−A41I−07 TCGA−QQ−A5VB−01A−11R−A36F−07 TCGA−DX−AB2Q−01A−11R−A39D−07 TCGA−Z4−AAPG−01A−11R−A39D−07 TCGA−MB−A5Y8−01A−11R−A29R−07 TCGA−SI−AA8B−01A−11R−A38C−07 TCGA−HB−A2OT−01A−11R−A21T−07 TCGA−X6−A8C2−01A−11R−A36F−07 TCGA−QC−A7B5−01A−11R−A33J−07 TCGA−SI−A71O−01A−12R−A33J−07 TCGA−IS−A3K7−01A−11R−A21T−07 TCGA−DX−A240−01A−32R−A27Q−07 TCGA−LI−A9QH−01A−11R−A37L−07 TCGA−QQ−A8VF−01A−11R−A37L−07 TCGA−DX−AB2Z−01A−11R−A38C−07 TCGA−DX−A8BS−01A−11R−A37L−07 TCGA−DX−A8BH−01A−11R−A37L−07 TCGA−SG−A849−01A−11R−A355−07 TCGA−DX−A6YQ−01A−12R−A33J−07 TCGA−DX−A3U8−01A−11R−A29R−07 TCGA−3B−A9HT−01A−11R−A39D−07 TCGA−X6−A8C3−01A−11R−A36F−07 TCGA−K1−A6RV−01A−11R−A32Q−07 TCGA−QC−A6FX−01A−11R−A32Q−07 TCGA−IE−A4EJ−01A−11R−A24X−07 TCGA−UE−A6QU−01A−12R−A32Q−07 TCGA−DX−A23U−01A−11R−A26T−07 TCGA−DX−A8BK−01A−11R−A37L−07 TCGA−DX−A8BO−01A−11R−A41I−07 TCGA−DX−A8BQ−01A−11R−A37L−07 TCGA−DX−A8BR−01A−11R−A41I−07 TCGA−DX−A8BT−01A−11R−A37L−07 TCGA−DX−A1L1−01A−11R−A24X−07 TCGA−DX−A23Y−01A−11R−A27Q−07 TCGA−3B−A9HO−01A−11R−A38C−07 TCGA−DX−A3LY−01B−11R−A27Q−07 TCGA−3B−A9HI−01A−11R−A38C−07 TCGA−DX−A2J1−01A−11R−A21T−07 TCGA−MJ−A68J−01A−11R−A30C−07 TCGA−DX−A1L4−01A−12R−A26T−07 TCGA−VT−A80J−01A−11R−A36F−07 TCGA−WK−A8XO−01A−11R−A37L−07 TCGA−DX−AB2S−01A−11R−A39D−07 TCGA−DX−AB32−01A−11R−A41I−07 TCGA−DX−A3U6−01A−11R−A29R−07 TCGA−3B−A9HJ−01A−11R−A38C−07 TCGA−UE−A6QT−01A−12R−A32Q−07 TCGA−DX−A1KZ−01A−11R−A24X−07 TCGA−DX−A3LT−01A−12R−A21T−07 TCGA−DX−A1L3−01A−11R−A24X−07 TCGA−DX−A6Z0−01A−13R−A36F−07 TCGA−MB−A8JL−01A−11R−A36F−07 TCGA−DX−A3UA−01A−12R−A30C−07 TCGA−DX−A6YZ−01A−12R−A355−07 TCGA−DX−A6BG−01A−11R−A30C−07 TCGA−DX−A3LS−01A−11R−A21T−07 TCGA−DX−A6BH−01A−12R−A30C−07 TCGA−DX−A8BG−01A−12R−A41I−07 TCGA−DX−AB2T−01A−11R−A38C−07 TCGA−DX−A6YU−01A−12R−A33J−07 TCGA−VT−AB3D−01A−12R−A41I−07 TCGA−3B−A9HS−01A−11R−A39D−07 TCGA−DX−A2J0−01A−11R−A21T−07 TCGA−K1−A6RU−01A−11R−A32Q−07 TCGA−DX−AB2O−01A−12R−A39D−07 TCGA−DX−A7EU−01A−22R−A36F−07 TCGA−DX−A48N−01A−11R−A30C−07 TCGA−QC−AA9N−01A−11R−A39D−07 TCGA−DX−A1KW−01A−22R−A24X−07 TCGA−DX−A6YR−01A−33R−A355−07 TCGA−DX−A1KX−01A−22R−A24X−07 TCGA−QQ−A5V9−01A−11R−A32Q−07 TCGA−DX−A8BL−01A−11R−A41I−07 TCGA−QQ−A8VG−01A−11R−A37L−07 TCGA−SI−A71P−01A−12R−A33J−07 TCGA−RN−A68Q−01A−11R−A30C−07 TCGA−RN−AAAQ−01A−21R−A39D−07 TCGA−DX−A8BJ−01A−11R−A41I−07 TCGA−KF−A41W−01A−11R−A24X−07 TCGA−WK−A8XQ−01A−11R−A37L−07 TCGA−IW−A3M5−01A−22R−A21T−07 TCGA−DX−AB3A−01A−11R−A41I−07 TCGA−Z4−A9VC−01A−11R−A37L−07 TCGA−FX−A2QS−01A−11R−A21T−07 TCGA−DX−A3M1−01A−11R−A22K−07 TCGA−DX−A23R−01A−11R−A26T−07 TCGA−DX−A8BM−01A−11R−A41I−07 TCGA−HB−A3YV−01A−11R−A24X−07 TCGA−DX−A1KU−01A−32R−A24X−07 TCGA−X9−A973−01A−11R−A38C−07 TCGA−JV−A5VF−01A−11R−A29R−07 TCGA−DX−A1KY−01A−11R−A24X−07 TCGA−VT−A80G−01A−11R−A36F−07 TCGA−DX−AB2L−01A−32R−A41I−07 TCGA−DX−AATS−01A−12R−A41I−07 TCGA−QQ−A5V2−01A−11R−A32Q−07 TCGA−LI−A67I−01A−31R−A30C−07 TCGA−DX−A3U5−01A−11R−A22K−07 TCGA−IE−A6BZ−01A−11R−A30C−07 TCGA−DX−A23V−01A−11R−A29R−07 TCGA−IF−A3RQ−01A−11R−A22K−07 TCGA−DX−A8BX−01A−11R−A37L−07 TCGA−DX−A1L2−01A−22R−A24X−07 TCGA−3B−A9HL−01A−11R−A38C−07 TCGA−DX−AB35−01A−21R−A41I−07 TCGA−DX−AB2F−01A−11R−A38C−07 TCGA−DX−A1L0−01A−11R−A24X−07 TCGA−DX−AB2G−01A−11R−A39D−07 TCGA−DX−AB2V−01A−11R−A41I−07 TCGA−DX−A3LU−01A−11R−A21T−07 TCGA−DX−A6BF−01A−11R−A30C−07 TCGA−MO−A47R−01A−11R−A24X−07 TCGA−DX−A3M2−01A−21R−A22K−07 TCGA−DX−A8BZ−01A−11R−A37L−07 TCGA−MB−A5Y9−01A−11R−A29R−07 TCGA−DX−A23T−01A−11R−A26T−07 TCGA−DX−A3LW−01A−21R−A21T−07 TCGA−DX−A2J4−01A−32R−A21T−07 TCGA−DX−A23Z−01A−11R−A27Q−07 TCGA−IE−A4EH−01A−11R−A24X−07 TCGA−HS−A5NA−01A−11R−A26T−07 TCGA−HB−A3L4−01A−11R−A21T−07 TCGA−WP−A9GB−01A−11R−A37L−07 TCGA−KD−A5QT−01A−11R−A27Q−07 TCGA−FX−A76Y−01A−11R−A355−07 TCGA−KD−A5QU−01A−11R−A27Q−07 TCGA−X2−A95T−01A−11R−A37L−07 TCGA−3B−A9I1−01A−11R−A39D−07 TCGA−JV−A5VE−01A−11R−A29R−07 TCGA−IS−A3K6−01A−11R−A21T−07 TCGA−3B−A9HV−01A−11R−A39D−07 TCGA−X6−A7WB−01A−11R−A355−07 TCGA−KD−A5QS−01A−11R−A27Q−07 TCGA−HS−A5N9−01A−11R−A26T−07 TCGA−3B−A9HR−01A−11R−A38C−07 TCGA−DX−A6BB−01A−12R−A32Q−07 TCGA−IE−A3OV−01A−11R−A22K−07 TCGA−X6−A7WA−01A−12R−A355−07 TCGA−DX−A48L−01A−11R−A30C−07 TCGA−DX−A3UE−01A−11R−A30C−07 TCGA−WK−A8XY−01A−11R−A37L−07 TCGA−DX−A48R−01A−11R−A30C−07 TCGA−DX−A7EN−01A−11R−A39D−07 TCGA−IE−A4EI−01A−11R−A24X−07 TCGA−DX−A6BA−01A−11R−A30C−07 TCGA−WK−A8XS−01A−11R−A37L−07 TCGA−DX−A3U9−01A−11R−A30C−07 TCGA−DX−A3U7−01A−11R−A29R−07 TCGA−X9−A971−01A−11R−A38C−07 TCGA−IF−A4AJ−01A−11R−A24X−07 TCGA−K1−A42W−01A−11R−A24X−07 TCGA−HB−A43Z−01A−11R−A24X−07 TCGA−MB−A5YA−01A−11R−A29R−07 TCGA−3B−A9I0−01A−11R−A39D−07 TCGA−DX−A6Z2−01A−12R−A36F−07 TCGA−DX−A48J−01A−21R−A30C−07 TCGA−WK−A8XX−01A−11R−A37L−07 TCGA−3B−A9HU−01A−11R−A39D−07 TCGA−DX−A7EL−01A−12R−A36F−07 TCGA−3B−A9HZ−01A−11R−A39D−07 TCGA−3B−A9HQ−01A−11R−A38C−07 TCGA−X6−A8C5−01A−11R−A36F−07 TCGA−DX−A3UD−01A−11R−A30C−07 TCGA−IW−A3M6−01A−11R−A21T−07 TCGA−MJ−A68H−01A−11R−A30C−07 TCGA−DX−A48U−01A−11R−A30C−07 TCGA−DX−A6B7−01A−11R−A30C−07 TCGA−IE−A4EK−01A−11R−A24X−07 TCGA−DX−A48O−01A−11R−A30C−07 TCGA−PC−A5DL−01A−11R−A26T−07 TCGA−DX−A48P−01A−11R−A30C−07 TCGA−HB−A5W3−01A−11R−A29R−07 TCGA−WK−A8XZ−01A−11R−A37L−07 TCGA−PC−A5DP−01A−11R−A26T−07 TCGA−K1−A3PN−01A−11R−A22K−07 TCGA−HS−A5N7−01A−21R−A26T−07 TCGA−DX−A7EM−01A−11R−A36F−07 TCGA−DX−A3UF−01A−11R−A30C−07 TCGA−PC−A5DO−01A−11R−A26T−07 TCGA−3B−A9HY−01A−11R−A39D−07 TCGA−IF−A4AK−01A−21R−A24X−07 TCGA−DX−A3UC−01A−11R−A30C−07 TCGA−IS−A3K8−01A−11R−A21T−07 TCGA−IW−A3M4−01A−11R−A21T−07 TCGA−K1−A42X−01A−11R−A24X−07 TCGA−FX−A3RE−01A−11R−A22K−07 TCGA−MO−A47P−01A−11R−A24X−07 TCGA−PC−A5DK−01A−11R−A27Q−07 TCGA−FX−A3NJ−01A−11R−A21T−07 TCGA−X6−A7WD−01A−21R−A355−07 TCGA−MB−A8JK−01A−11R−A36F−07 TCGA−3B−A9HP−01A−11R−A38C−07 TCGA−DX−A7ES−01A−31R−A39D−07 TCGA−PC−A5DN−01A−12R−A27Q−07 TCGA−DX−A6BE−01A−41R−A32Q−07 TCGA−N1−A6IA−01A−12R−A32Q−07 TCGA−DX−A6B9−01A−12R−A32Q−07 TCGA−K1−A3PO−01A−11R−A21T−07 TCGA−FX−A48G−01A−11R−A24X−07 TCGA−DX−A3UB−01A−11R−A30C−07 TCGA−3B−A9HX−01A−11R−A39D−07 TCGA−FX−A3NK−01A−11R−A21T−07 TCGA−3B−A9I3−01A−11R−A39D−07 TCGA−DX−AB2P−01A−11R−A38C−07 TCGA−SG−A6Z4−01A−22R−A33J−07 TCGA−DX−A8BV−01A−11R−A37L−07 TCGA−DX−A6YS−01A−12R−A355−07 TCGA−DX−A8BN−01A−11R−A37L−07 TCGA−DX−A6YT−01A−21R−A355−07 TCGA−DX−A6YV−01A−12R−A355−07 TCGA−DX−A8BU−01A−11R−A37L−07 TCGA−DX−A7EF−01A−11R−A33J−07 TCGA−DX−A8BP−01A−11R−A37L−07 TCGA−DX−A6B8−01A−11R−A30C−07 TCGA−PC−A5DM−01A−11R−A27Q−07 TCGA−DX−AB36−01A−11R−A41I−07 TCGA−FX−A3TO−01A−11R−A22K−07 TCGA−X6−A8C6−01A−11R−A36F−07 TCGA−DX−AB37−01A−11R−A41I−07 TCGA−DX−AB2W−01A−11R−A39D−07 TCGA−DX−A48K−01A−11R−A30C−07 TCGA−Z4−AAPF−01A−11R−A39D−07 TCGA−K1−A6RT−01A−32R−A33J−07 TCGA−IS−A3KA−01A−11R−A21T−07 TCGA−DX−AB3C−01A−11R−A41I−07 TCGA−DX−AB3B−01A−11R−A41I−07 TCGA−FX−A8OO−01A−11R−A36F−07 TCGA−WK−A8XT−01A−11R−A37L−07 TCGA−DX−A7ER−01A−11R−A36F−07 TCGA−X6−A8C7−01A−11R−A36F−07 TCGA−DX−A7EO−01A−11R−A36F−07 TCGA−MJ−A850−01A−11R−A355−07 TCGA−DX−A7EQ−01A−11R−A466−07 TCGA−DX−AB2J−01A−11R−A38C−07 TCGA−DX−A7ET−01A−11R−A36F−07 TCGA−X6−A7WC−01A−12R−A355−07 TCGA−X6−A7W8−01A−21R−A355−07 TCGA−QQ−A5VD−01A−21R−A32Q−07 TCGA−DX−AB2H−01A−11R−A39D−07 TCGA−DX−A2IZ−01A−11R−A21T−07 TCGA−JV−A75J−01A−11R−A32Q−07 TCGA−HS−A5N8−01A−11R−A26T−07 TCGA−QQ−A8VH−01A−11R−A37L−07 TCGA−SI−A71Q−01A−12R−A33J−07 TCGA−SI−AA8C−01A−11R−A38C−07 TCGA−SG−A6Z7−01A−12R−A32Q−07 TCGA−DX−A7EI−01A−11R−A33J−07 TCGA−PT−A8TR−01A−11R−A37L−07 TCGA−QQ−A8VB−01A−11R−A37L−07 TCGA−QQ−A5VA−01A−12R−A32Q−07 TCGA−DX−AB30−01A−11R−A39D−07 TCGA−QQ−A5VC−01A−31R−A32Q−07 S100A7L2 OR4D10 OR2Y1 OR7D4 NANOGNB DPP TF OR4N2 GABRA6 PRLH GSC2 SMR3B SLC17A6 NEUR FGF4 TRIM49B KR CLEC2A KR F CLPSL1 GIF H2AFB1 REG3A CLPS MUC21 OR52E8 SLC17A4 UCN3 SP FTHL17 TMEM207 FO AD CT47B1 CFC1 TRIM40 GSX1 ALPI UMOD OTOL1 RGS21 KR DCD SCGB2A1 TISP43 SLC22A6 KR PSG6 KR LCE2A APO XA PPP1R2P9 DCAF8L1 SMCP PDCL2 LINC01207 CRH KLHL1 OTOR KR AKAIN1 A PNMA6F KR C1orf141 LGALS7 P NCR2 BARHL1 ANHX ST RAX2 SI CA IQCJ CLC CDR TNP1 SERPINA7 BMP10 HEL UGT2B11 PRSS1 INSL4 LIPF GNA MS4A10 SFTP B3GNT6 L MUC17 DCAF4L2 POU3F4 MA AWA TECRL A ASB15 CTXN3 ANTXRL KAA PGA3 TUBA3C RFPL1 SLC5A8 CWH43 RFX6 ADGRG7 PRDM9 ARL14EPL KR CSN1S1 EPGN TYR SP SP CSA F CLDN19 PMP2 SPRR1A SPRR1B KR FGFBP1 FO MSMB RNF223 KR PLA2G4F GKN2 GKN1 DNTT CSN3 AMTN ANKRD34C ITLN2 AR ASB10 LMAN1L ELSPBP1 FEZF2 TBX22 P AKAP4 A NPY4R ALKAL1 PRB1 PRB2 KLK5 KLK6 PDX1 CDX2 PRDM7 OLFM3 APOF WNT7A CPLX2 PR IL17C PRLHR NKX6−2 IFITM5 HRH3 LHX3 SPHKAP ABCC12 HCR SOHLH1 F9 HRG UGT2B15 SERPINA4 F KNG1 P AHSP MEP1A TRPM1 TDRD1 SFTP PGC NPPB TM4SF20 A P2RX3 CCDC63 ADGB NANOG C1orf87 KR KR TFF1 TFF2 REG1A MUC5A CTSE CXCL17 F BPIFB1 UGT2B7 A CTRB2 A PPY KR KR AWA OBP2A CRP KR KR CST1 SERPINB7 KR KR KR PSG9 PSG5 GPR21 KBTBD13 ADGRF2 LINC00675 FRG2C RBP2 LMNTD1 SERPINA12 SERPINA11 FETUB AHSG WFDC6 EPPIN KR DRD5 NGB BRS3 A GMNC CA GABRA4 F IRS4 SYT10 FUT9 PRR32 SERPINI2 MOG PSMA8 FCAMR DUPD1 CCDC60 RP1 RD3 MAS1L A GFI1B GATA1 AMHR2 A F C1orf105 MRLN THEG MYL7 RHBG RAX SO A PCP4 LMO1 SLC7A3 DCX PRIMA1 NP RPE65 ENAM C12orf54 GLRA4 TMEM252 KCTD4 DMR CF TBR1 TPH2 DGKK PIWIL3 SBK2 FBP2 P HO OD NKAIN3 ARHGAP36 NR0B1 SLC36A2 F C2orf71 SOST SYT8 NPHS1 HAND1 GATA4 NR5A1 FMR1NB TNNI3 KLK10 AMPD1 MYL2 CO CA MYH7 MYL1 C10orf71 MYH2 MYH1 OSTN PRL ITLN1 LGALS9B LGALS9C SERPINA6 NR1H4 NMRK2 LMOD2 XIRP2 ABRA HFE2 TRIM54 A NRAP CPNE6 TCEAL6 RPRML CELF3 CCKBR MORN5 PCP4L1 PGPEP1L GSG1L PRSS2 DPCR1 SLC26A3 ERN2 TDGF1 C4BP SSTR3 CR2 TCL1A PNOC P KR TPSD1 CMA1 FBXO40 MYBPC1 PPP1R27 APOBEC2 PR SLC45A2 KCNK9 AP1M2 DMBT1 HHA TNNI1 MYBPC2 TNNT2 MY IRX4 AD STMN2 ENTHD1 NTSR1 PLA2G1B GRIN1 MUC6 CD177 SBSN NRG3 IL1RAPL1 LP DMR GBX2 DLGAP2 NET KCNJ6 DCDC2 MMP7 IGF2BP1 TRPM8 BNC1 DUO MUSTN1 A4GNT SFTPB FREM3 NCAN MAEL T PNMA5 O OLFM4 GLP2R ANGPTL7 SCN7A TYRP1 HTR1B GD SLC27A6 HCN4 CLDN3 PLA2G10 NWD1 RHCG C2CD4A R CTNND2 TNR PNLDC1 GPR37L1 FSD2 COL28A1 GF TRPV6 F S100P TRIM67 SCG3 SPX RAB44 SLC18A2 PTPN5 ITIH2 FER1L5 LEFTY1 APO INHA ITGA8 RASL12 A LMOD1 MYH11 PR PPP1R12B MYLK TNNT3 L BCAS1 L CD22 PLA MPZ TNNC2 NEB A TCAP A MMP9 PTH1R F LDB3 WFDC1 ADCY5 CHI3L1 S100A2 FOSL1 ETV4 GATA2 TTN CCL19 C1orf186 HDC CTSG CP TPSAB1 TPSB2 CALB2 ADCY MB MY MY CKM TNNC1 VW RPL3L MLANA CHIT1 V A MY CLDN18 BGLAP IGFN1 PTCHD1 CA3 A F CASQ2 RXFP1 NIP MTTP GPR17 DUO CNR1 GPM6A GRM1 FHL5 ITIH3 CDH1 EPPK1 CASQ1 PRR26 AD ALDH1L1 P2RX1 PMEL YPD2 Y6K TF A AM9A ABP1 AM159B AM83C AM9B AM83B AM135B AM19A3 AIM2 ANX3 A AH AX2 AX5 TP2A1 VP GF C104831.1 C245041.1 CO GR2 CTL8 GBL1 QP10 C004233.2 GTR2 C083902.2 OC3 CP5 CPP CT TBDN V AR3 C3 AP2D AR1 GE4 ATA31A1 ANXC ANXB1 OML3 AP47 AS4 A3 GE3 AP XR2 XI1 AD1 ARB2 UNE2 AMTS8 OL3 T74 T37 T T T38 T77 T25 CNG3 T20 T6C T32 T1 T27 T24 T78 T79 T6B T6A T T T34 T9 CNG5 CNA1S T1 OKR2 OZ X3 O18B O OZ1 O1H XD12 X6A2 AM A GEA10 AL4 A3B T AP13−4 AP1−1 AP2−3 AP1−5 A1 C8 A3 O1 G1 TL G2 T3 T1 T2 A4 A1 T6 T15L2 TR2 T XA2 X2 T1 T A1 A2 A AP1 A2 OD4 C