Anti-RNF5 (Aa 1-180) Polyclonal Antibody (DPABH- 04800) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-RNF5 (aa 1-180) polyclonal antibody (DPABH- 04800) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin- conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the Lys-48-linked polyubiquitination of TMEM173 at Lys-150 leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses.

Immunogen Recombinant fragment, corresponding to a region within amino acids 1-180 of Human RNF5 (Q99942).

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB

Format Liquid

Size 100 μl

Buffer pH: 7.00; Constituents: 0.75% Glycine, 1.21% Tris, 20% Glycerol

Preservative None

Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol RNF5

Synonyms RNF5; ring finger protein 5, E3 ubiquitin protein ligase; RMA1; RING5; E3 ubiquitin-protein ligase RNF5; protein G16; ram1 homolog;

Entrez Gene ID 6048

Protein Refseq NP_008844.1

UniProt ID A0A024RCQ4

Pathway Protein processing in endoplasmic reticulum;

Function ligase activity; protein binding; ubiquitin-protein transferase activity; zinc ion binding

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]