Time Time GMT EST The Festival of Genomics & Biodata - Agenda Day 1 An Update on Genomics in the NHS 9.00 4.00 Dame Sue Hill, CSO, NHS England

Reducing Pediatric Cancer to Zero 9.30 4.30 Jack DiGiovanna, SVP, Director of Programs, Seven Bridges, Mark Cowley, Computational Biology Group Leader, Children's Cancer Institute, Conjoint Associate Professor, School of Women's and Children's Health, UNSW Medicine

UK/EUROPE KEYNOTES UK/EUROPE Using Healthcare Data in Research to Improve Lives 10.00 5.00 Caroline Cake, CEO, Health Data Research UK Break & Innovation Talks A step forward in library preparation for Illumina systems Running Genomics Pipelines on Cloud at scale 10.30 5.30 Sponsored by Thermo Fisher Hatem Nawar, Customer Engineer, Google Cloud

Sage Size Selection Products for Long-read Sequencing Make your Single Cell RNA-Seq analysis easy with Partek Flow Track 2 Track 10.45 5.45 1 Track Chris Boles, Chief Scientific Officer, Sage Science - Sponsored by LabTech Simit Patel, Field Application Scientist, Partek 1. CLINICAL GENOMICS 2. GENOMICS IN RESEARCH A 3. GENOMICS IN RESEARCH B 4. BIODATA 5. CANCER GENOMICS MASTERMIND SESSIONS Panel: Is Machine Learning the Key to Uncovering Genomic Evidence for Unlocking RWE? Reinfection with SARS-CoV-2: a Case Structural variants at BRCA1/2 and Clinical Microbial Metagenomics and Exploring the Clinical Application of Study HR deficiency in Tumours Fecal Microbiota Transplantation Paul Agapow, Health Informatics Director, Single Cell Analysis in Liquid Biopsy 11.00 6.00 AstraZeneca Joel R Sevinsky, Principal, Theiagen Ailith Ewing, UKRI Innovation Fellow, Florian Fricke, Professor, University Victor Neduva, Senior Principal Scientist, Bernhard Polzer, Head of Molecular Consulting LLC University of Edinburgh of Hohenheim MSD Diagnostics, Fraunhofer ITEM Sponsored by Qiagen Natalie Gavrielov, Director of Medical Writing, BioForum 11.30 6.30 Next-Generation Cytogenomics with Shaping the Disease Microbiome with Machine Learning Approaches to A Complete Workflow for Analysis of 11.40 6.40 Optical Mapping is Here! To Stay! Dietary and Lifestyle Interventions Drug Resistance and Variant Effect cfDNA: From Plasma to Variants Prediction Panel: COVID-19 & Genomics - The Gianni Panagiotou, Head Systems Biology Nicole Roseman, IDT Alka Chaubey, Chief Medical Officer, UK's response and Bioinformatics, Leibniz Institute of Shilpa Parakh, Beckman Coulter Life Bionano Genomics John Overington, Chief Information Natural Product Research and Infection Sciences

Biology Hans Knoll Institute(HKI) Officer, Catapult Medicines Sponsored by Beckman Coulter Life MASTERMIND

Angela Douglas, Deputy CSO, NHS LIQUID BIOPSY Sponsored by Bionano Genomics Sponsored by Novogene Discovery Sciences GENOMIC MEDICINE England How can we support and foster innovation

11.50 6.50 MICROBIOMEHUMAN Richard Scott, Clinical Director, in the UK Genomics ecosystem via

Genomics England A Time to Sequence in Clinical Liquid Biopsy: From Discoveries to entrepreneurship? STRUCTURAL VARIATION STRUCTURAL DETECTION Naomi Allen, Chief Scientist, UK Cytogenetics The Gut Microbiome in ANALYSIS ADVANCING DATA Clinical Implementation Anya Roy, Head of Seed Investments and BioBank Inflammatory Bowel Diseases Technology, EMEA, Illumina Accelerator Zahid Latif, Innovation Specialist, 12.00 7.00 Mod: Joel R Sevinsky, Principal, Cynthia Morton, Director of Catherine Alix-Panabieres, Director Department of International Trade Theiagen Consulting LLC Cytogenetics, Brigham and Women’s Melanie Schirmer, Group Leader, of Laboratory of Rare Human Joanne Hackett, Head of Precision & Hospital, and Institute Member, Technical University Munich Circulating Cells, The University of Genomic Medicine, IQVIA Broad Institute of MIT and Harvard Montpellier Paul Dowling, Advisor, KQ Labs Jason Mellad, Co-Founder and CEO, Live Lounge Lunch Talks Saliva as a diagnostic tool for COVID-19: A comprehensive extraction-based workflow from collection to detection 12.30 7.30 Kiranmai Durvasula, Product Manager, Omega Bio-tek, Inc

Making A Million Actionable 12.45 7.45 Brandi Davis-Dusenbery, Chief Scientific Officer, Seven Bridges

Differentiate DNA from RNA using NanoDrop spectrophotometers 13.00 8.00 Patrick Brown, Product Marketing Specialist, Thermo Scientific NanoDrop Products, Thermo Fisher Scientific

Deciphering the Methylome: Enzymatic Methyl-seq, a new alternative to bisulfite sequencing 13.15 8.15 Adam Peltan, Senior NGS Technical Application Specialist, New England Biolabs

13.30 8.30 Networking Break + Exhibition Hall

1. CLINICAL GENOMICS 2. GENOMICS IN RESEARCH A 3. GENOMICS IN RESEARCH B 4. BIODATA 5. CANCER GENOMICS MASTERMIND SESSIONS How 3D bioprinting is contributing to the The Microbiome of Idiopathic Exploiting the Multiple Modalities Exploring the Somatic-Germline Genomically Humanised Mouse future of medicine Clinical Utility of Liquid Biopsies Neurodegenerative Diseases Underpinning Population Diversity Interface in Precision Oncology: A Models of Neurodegenerative (MIND) using AI and XAI Clinical Perspective Disease Mod: Garder Butterworth, CELLINK 13.40 8.40 Klaus Pantel, Chairman, Department Martin Tomov, Emory University of Tumor Biology, University Medical J. Christopher Ellis, Senior Staff Jean-Baptiste Cazier, Director of the Anju Kulkarni, Consultant Clinical Andrew Lee, Fluidform Thomas Cunningham, Senior Center Hamburg-Eppendorf Scientist, Oak Ridge National Centre for Computational Biology, Geneticist, Guy's and St Thomas' Tania Baltazar, Yale School of Medicine Investigator Scientist, MRC Laboratory University of Birmingham NHS Foundation Trust Deepak Kalaskar, UCL Andrew Ridley, CELLINK 14.10 9.10 CRISPR Validation and Resolving Exploring MSI Screening 3D Genetics, EpiSwitch™ and Clinical Nucleic Acid Purification - Understand the Young Scientist: The noise of Complex Genomics Landscapes with Technologies Translation. Development of Liquid Biopsy details, tackle the routines! silence: exploring the deep Xdrop™ for Diffuse large B-cell lymphoma (DLBCL) Andreas von Bohl, Head of R&D proteome reveals hidden treasures Prognosis and Benchmarking it against Bioanalysis automation group, MACHEREY- Pamela Ward, Scientific Director of 14.20 9.20 in our genome digital PCR Gold Standards Peter Mouritzen, Vice President NAGEL molecular pathology, University of Ewan Hunter, Director, Institute of Application and Market Tim Schommartz, Global Marketing Southern California Clinical

Marie Brunet, Post-Doc, University MASTERMIND Computational Biology, Oxford Biodynamics Development, Samplix Manager, Eppendorf Laboratories

Sponsored by Agilent Sponsored by Eppendorf of Sherbrooke CLINICAL SEQUENCING 14.30 9.30 Sponsored by Samplix PRECISION ONCOLOGY Sponsored by Promega Accelerating the speed of discovery: MICROBIOME SEQUENCING Improving NGS success rates while reducing Harnessing circulating tumor DNA to Identification of Functional Proteins Precision Oncology Therapeutic costs ADVANCING GENOME DATA ANALYSIS GENOME ADVANCING DATA Exome Sequencing of Large Cohorts inform clinical decisions Densely Co-Encoded in the Human DoMI, a Database of Microbe-Host Development Ana Dinarina, Thermo Fisher Scientific Can Guide Drug Discovery Mike Hubank, Royal Marsden Hospital

VALIDATING ENGINEERED GENOME COMPLEXITY ENGINEERED VALIDATING Genome Interactions for Drug Discovery 14.40 9.40 Wojciech Makalowski, University of Samantha Hasenleithner, Andrew Biankin, Director of the Paul Nioi, Senior Director, Research, Münster Researcher, Medical University of Alex Khitun, Postdoctoral Julia Maritz, Senior Scientist, Merck Wolfson Wohl Cancer Research Alnylam Pharmaceuticals Guillermo del Angel, Alexion Graz Researcher, Harvard University Centre, University of Glasgow Joby Jenkins, SPT Labtech Sigita Činčiūtė, Thermo Fisher Scientific Break & Innovation Talks Accelerate COVID-19 and NGS Workflows with Quantabio’s New Technologies Novogene transcriptomic and epigenomic solutions for human research 15.10 10.10 Ishna Mallinson, Field Application Specialist, Europe, QuantaBio Wei Li, Senior Product Manager, Novogene

Tackling genome complexity, one molecule at a time Hamilton´s suite of Microlab® automation solutions for Genomics and Clinical Genomics Track 2 Track 15.25 10.25 1 Track Anja Brunner, Marketing Manager, Samplix, Cecilie Nyholm Andersen, Field Application Scientist, Samplix Birgit Ottenwaelder, Senior Market Segment Leader Genomics, Hamilton Bonaduz AG 1. CLINICAL GENOMICS 2. GENOMICS IN RESEARCH A 3. GENOMICS IN RESEARCH B 4. BIODATA 5. CANCER GENOMICS MASTERMIND SESSIONS Multiplying discoveries with multi-omic Panel: Are Long-Reads the End of Short- approaches: strategies, case studies and Integrating Genomics into Routine Using Whole Exome Sequencing Reads? discussion Clinical Practice: Improving David Smith, Emeritus Professor, Mayo Clinic Digital Pathology at the Intersection Data to Understand Autoimmune NGS in CRUK's Precision Oncology Outcomes and Avoiding Harm Mike Hubank, Head of Clinical Genomics, The of Genomics, Big Data and AI Phenotype Portfolio Greg Michelotti, Scientific Director of 15.40 10.40 Royal Marsden NHS Foundation Trust Biology, Metabolon John McDermott, Academic Clinical Matt Loose, Professor, University of Steven Hart, Senior Associate Sarah Ennis, Professor of Genomics Maria Antonietta Cerone, Research Nima Aghaeepour, Assistant Professor, Fellow, Manchester Centre for Nottingham Consultant, Mayo Clinic with Medicine, University of Programme Manager, CRUK Stanford University Andrew Beggs, Professor, University of Genomic Medicine Southampton Tonya Ward, Director of Data Science and Birmingham Bioinformatics, Diversigen Ioanna Tzoulaki, Professor, Imperial 16.10 11.10 Identification of 370 Loci for Age at Onset Better than Exomes, better than The All of Us Research Program: College Enabling Genomic Medicine: Using Hybrid Genome Assembly to of Sexual and Reproductive Behaviour, Panels - Comprehensive Genomic Strategies to Collect 1 million Analysis at Scale Explore Plasmid Diversity in Non- Highlighting Common Aetiology with Profiling Samples Amidst the Pandemic Clinical Bacterial Populations Reproductive Biology, Externalizing 16.20 11.20 Behaviour and Longevity Nick Lench, Chief Scientific Officer, Bernhard Busch, Senior Oncology Jordan Weyer, Technical Specialist II,

Congenica Liam Shaw, Postdoctoral Fellow, NGS TESTING

Field Specialist Europe, Eurofins MASTERMIND Mayo Clinic Natalie van Zuydam, Senior Statistician, Sponsored by Congenica University of Oxford Genomics GENOMIC MEDICINE Sponsored by DNA Genotek Data Science and Quantitative Biology, 16.30 11.30 AstraZeneca Sponsored by Eurofins Genomics Machine Learning/Artificial

LONG SEQ RANGE & MAPPING Intelligence: Opportunities,

ADVANCING GENOME DATA ANALYSIS GENOME ADVANCING DATA From Monogenic to Complex Challenges faced and Lessons Synergistic Skill-Sets in Clinical Histogenomics and Beyond: NGS Technologies that are Driving HISTO-GENOMICS & DIGITAL PATHOLOGY Disease – Evolving Insights from learned Genomics Unleashing the Power of Digital New Cancer Therapies Genetic Rare Diseases Pathology for Precision Medicine 16.40 11.40 Annalisa Pawlosky, Google Meriel McEntagart, Consultant Jadwiga Bienkowska, Senior Guillermo del Angel, Sr. Director, Tyler Lu, Founder, Stealth Startup Geneticist, St George's University George Yousef, Chief of Paediatric Director, Head of Computation Data Science, Genomics and Virginie Uhlmann, EBI Hospital Laboratory Medicine, SickKids Biology Oncology R&D, Pfizer Bioinformatics, Alexion Pearse Keane, Moorfield Eye Hospital Break & Innovation Talks 17.10 12.10 Introducing Macrogen Europe's comprehensive and cost effective RNA sequencing solutions for today's research

Mohammad Ali, NGS Account Manager, Macrogen Track 1 Track NHGRI's Genomic Strategic Plan 17.30 12.30 Eric Green, Director, National Human Genome Research Institute

Advancing Medicine Through Data Sharing and Collaboration on a Global Scale 18.00 13.00 Heidi Rehm, Chief Genomics Officer, Massachusetts General Hospital, and Institute Member, Broad Institute of MIT and Harvard

GLOBAL KEYNOTES GLOBAL The Drama of Ever Rarer: Individualized Genomic Medicines as Rare as N-of-1 18.30 13.30 Lynn Bush, Boston Children's Hospital, Eric Green, NHGRI, Timothy Yu, Boston Children's Hospital, Cynthia Morton, Brigham and Women's Hospital, Janina Jeff, Illumina, Karen Rothenburg, Johns Hopkins Time Time GMT EST The Festival of Genomics & Biodata - Agenda Day 2 Genome UK – Implementing Our Vision 9.00 4.00 Lord Bethell of Romford, Parliamentary Under Secretary of State (Minister for Innovation), UK Department of Health and Social Care

Ready for Lift Off: The Next Decade of Human Genomics 9.30 4.30 Ashley Van Zeeland, PhD. MBA, Vice President, Product Integration and Customer Collaboration, Illumina

Updates on the UK Biobank for 2021 and Beyond

10.00 5.00 KEYNOTES UK/EUROPE Mark Effingham, Deputy CEO, UK BioBank Break & Innovation Talks Genomics England – beyond 100,000 genomes Alissa Interpret, the most mature and comprehensive clinical decision platform 10.30 5.30 James Duboff, Strategic Partnerships Director, Genomics England Jonatan Taminau, Alissa FAS Manager, Agilent Technologies

QIAGEN Genomics – SARS-CoV-2 sequencing solutions How to get more from your research data: bioinformatic data analysis report Track 2 Track 10.45 5.45 1 Track John Cousion & Syed Abedi, Professional Customer Solutions Managers, Genomics, QIAGEN Fios Genomics 1. CLINICAL APPLICATIONS OF 2. DRUG DISCOVERY AND 3. RESEARCH TECHNOLOGY 4. HEALTHCARE DATA 5. ONCOLOGY & RARE DISEASES MASTERMIND SESSIONS START-UP ZONE GENOMICS DEVELOPMENT Using Genetics to Understand the Multiomics in current and future scientific Using Genomics to Track and Defeat Unlocking the power of real-world data in Molecular stratification onto a COVID-19 personalised medicine: linkage of Going Beyond FAIR to Create a Excess Risk of Cardiometabolic research and clinical diagnosis national lung cancer precision Rob Ewing, Associate Professor, Proteomics genomic data to national cancer datasets Connected Data Ecosystem Disease in Individuals with Severe medicine trial: infrastructure, and Systems Biology, University of Sharon Peacock, Professor of within ’s National Mental Illness 11.00 6.00 delivery and challenges Southampton Microbiology, Cambridge University and Disease Registration Service Susan Gregurick, Associate Director Aina Pi Roig, TS Supervisor of Clinical Services, Director of COG-UK for Data Science, National Institutes Rona Strawbridge, Rutherford Fund Don White, Programme Manager, Novogene Judith Breuer, Professor of Virology and Steven Hardy, Head of Molecular of Health Fellowship at HDR-UK, UKRI CRUK Yuanyuan Chen, Sales Director, Novogene Director, Pathogen Genomics Unit at UCL Diagnostics, Public Health England Innovation Ricard Argelaguet, Post doctoral Researcher, EMBL EBI 11.30 6.30 From persisting Borrelia to chronic Lyme Analysis of simple and complex genomic disease: Vitality of atypical and persistent Can NGS drive clinical adoption of Using Human Genetics to Improve alterations for comprehensive genomic forms of Lyme disease spirochetes biomarkers? the Odds of Drug Development profiling (CGP) of solid tumors using a single Natasha Rudenko, Deputy Head of the Accelerating Research in the Cloud 11.40 6.40 NGS workflow laboratory of Molecular Ecology of Vectors Ines Beumer, Manager Innovation & Michael Holmes, Professor, Medical Raed Samara, Associate Director, Global and Pathogens, Institute of Parasitology, Funding, GenomeScan Rowland Illing, Director and CMO Research Council, Population Health ONCOLOGY Product Management, NGS, QIAGEN

Biology Centre CAS Sponsored by GenomeScan Government Healthcare, AWS Research Unit, University of Oxford Sponsored by QIAGEN MASTERMINDS HEALTHCARE DATA HEALTHCARE

INFECTIOUS DISEASES Sponsored by ThermoFisher 11.50 6.50 Pete Sinden, CIO, Genomics England COMPANION DIAGNOSTICS Mark Effingham, Deputy CEO, UK Milton Keynes Lighthouse FLT3 inhibitors added to induction Young Scientist: DNA methylation Functional Variomics and Network Biobank Laboratory: Developing UK therapy result in deeper remissions: profiling in blood samples from Biology to Empower Innovative Rob Denison, CIO, Congenica Interactive sessions moderated with Infrastructure for High Throughput evidence from a novel assay for individuals with schizophrenia Precision Medicine 3-4 starting contributors & audience 12.00 7.00 COVID-19 Testing measurable residual disease (MRD) Sponsored by AWS participation Aysheh Alrfooh, Graduate Research Stephen Yi, Director of Tony Cox, Chief Executive Officer, UK Ken Chang, Director of Clinical Assistant, University of Iowa Bioinformatics, The University of Biocentre Biomarkers, Daiichi Sankyo Texas

Identify, Preserve and Process Samples using 2D Barcoded Sample Storage Tubes 12.30 7.30 Emma Ryan, Director and CO-Founder, AltemisLab

The COVID Automated Testing Dichotomy in UK – Deployment of Assay Ready Workstations and/or a Centralised Approach to High Throughput Screening 12.45 7.45 Stephen Hughes, Country Manager UK and Ireland, Hamilton Robotics Rapid WGS for critically ill children in Wales - Joseph Halstead, Lead Bioinformatician, AWMGS 13.00 8.00 Implementing new cancer services at AWMGS - Laura McCluskey, Bioinformatician, AWMGS

13.15 8.15 An introduction to AWMGS and the AWMGS bioinformatics team - Erik Waskiewicz, Lead Bioinformatician, AWMGS

13.30 8.30 Networking Break + Exhibition Hall

1. CLINICAL APPLICATIONS OF 2. DRUG DISCOVERY AND 3. RESEARCH TECHNOLOGY 4. HEALTHCARE DATA 5. RARE DISEASES MASTERMIND SESSIONS START-UP ZONE GENOMICS DEVELOPMENT Translating from scientist to Patient-Centered Precision Health In Young Scientist: Data-driven design Linking the UK Healthcare entrepreneur - what you need to Gene Discovery in severe psychiatric 13.40 8.40 A Learning Health Care System: of targeted gene panels for An Approach to Nanopore Leveraging Human Genetic Studies Ecosystem from Drug Discovery to know disorders at Boston Children’s Geisinger’s Genomic Medicine estimating immunotherapy Sequencing for Identification of New Targets the Clinic Alessia Errico, Regional Translational Hospital Experience biomarkers Lead, CRUK Wojciech Makalowski, Professor, Nilanjana Sadhu, Research Scientist, Kate Witkowska, Genomics England Catherine Brownstein, Professor, EnterpriseTECH - Investigating the Marc Williams, Director of Genomic Jacob Bradley, PhD Student, University of Munster Biogen Jenny Taylor, University of Oxford Harvard commercialisation of emerging 14.00 9.00 Medicine Insitute, Geisinger University of Edinburgh Pierre Farmer, NIBR technologies Jan Krieg, Boehringer Ingelheim Ghina Halabi, Programme Manager, EnterpriseTECH 14.10 9.10 Using targeted nanopore Panel: What Data is Available in the European Joint Programme on Rare technologies to sequence full-length Healthcare System? Diseases mitochondrial genomes How Innovators can get support in Ashlee Hamel, System Manager, the UK Genomics Ecosystem 14.20 9.20 Daria Julkowska, Assistant Director,

Brittany Pielstick, PhD Candidate, Pharmacy Clinical Programs, Sentara

RARE DISEASES MASTERMINDS

Thematic Institute of Genetics, ZONE START-UP Joanne Hackett, Head of Precision

John Hopkins Medicine DATA HEALTHCARE Healthcare

GENOMIC MEDICINE Genomics & Bioinformatics, INSERM, PHARMACOGENOMICS Elizabeth George, Director, Clinical and Genomic Medicine, IQVIA NANOPORE SEQUENCING Co-ordinator, EJRP 14.30 9.30 Sponsored by Oxford Nanopore Trial Diversity, GSK RNA Sequencing 3D Health Initiative and Genomic Discussion: Polygenic Risk Scores in Assembling the Genome of the Puneet Dhawan, GSK Efforts at UCSF The Open Science Experience of the Pharmacogenomics Tasmanian Devil with Oxford Nicholas Harvey, King's College A Founder's Story Rare Disease Community Nanopore London 14.40 9.40 Aleks Rajkovic, Chief Genomics Charles Paulding, Senior Director, Helen Roberts, AWMGS Patrick Short, Founder & CEO, Sano Officer, UCSF Pharmacogenomics, Regeneron Segolene Ayme, Medical Geneticist, Zemin Ning, Senior Scientific Riccardo Rossi, INGM Genetics Sawona Biswas, Director of 3D Aviv Madar, Lead Analyst, Novartis INSERM Manager, Wellcome Sanger Institute Mohammad Ali, Macrogen Health study, University of California Sridevi Ponduru, Medical Director, Takeda Sjoert Jansen, Macrogen Break & Innovation Talks Sequential isolation of DNA and RNA from the same FFPE DNA/ RNA 96 kit Spectrum Compact Capillary Electrophoresis System for Sanger Sequencing and Fragment Analysis Applications 15.10 10.10 Omega Bio-Tek Robert Mclaren, Senior R&D Scientist, Promega

Gene Regulation Platform accelerating drug discovery from target identification to the preclinical stage Identify, Preserve and Process Samples using 2D Barcoded Sample Storage Tubes Track 2 Track 15.25 10.25 1 Track Marek Piatek, Director of Bioinformatics, Ardigen, Marek Kudla, Lead Bioinformatician, Ardigen Emma Ryan, Director and CO-Founder, AltemisLab 1. CLINICAL APPLICATIONS OF 2. DRUG DISCOVERY AND 3. RESEARCH TECHNOLOGY 4. HEALTHCARE DATA 5. RARE DISEASES MASTERMIND SESSIONS START-UP ZONE GENOMICS DEVELOPMENT Liquid biopsy in genomics: Past present and Discussion: The Merits and Are Phenotyping Algorithms Fair for future perspectives Harnessing Synthetic Biology and Functional Genomics for Drug Shortfalls of Different Technologies Underrepresented Minorities The Importance of Specialised Andrew Feber, Deputy Director of Clinical Deep Learning to Fight Pandemics Discovery Within Older Adults? Nursing for Rare Diseases Genomics, The Royal Marsden, NHS 15.40 10.40 David Smith, Emeritus Professor, Foundation Trust, Office Hours: Sessions to support James J. Collins, Professor, MIT, and Bahram Arezi, Head of NGS Library Prep, Christopher Miller, Head of Mayo Clinic Juan M. Banda, Assistant Professor Gill Moss, Clinical Nurse Lead for new entrepeneurs & showcase start- Institute Member, Broad Institute of Agilent Functional Genomics, GSK Shawn Baker, Advisor, of Computer Science, Georgia State Rare Diseases, NHS up companies MIT and Harvard Samantha Hasenleithner, Researcher, SanDiegOmics University Medical University of Graz Francesca Salvianti, Researcher, University 16.10 11.10 Digital PCR Mutation Assays with of Florence Pooled CRISPR Screens Identify Improving Drug Discovery with Locked Nucleic Acid (LNA) Why Diversity Matters in Human Novel Targets and Resistance to Large Scale Genomics Technology for Rare Target Genomics Research Office Hours: Sessions to support Cancer Treatments Detection 16.20 11.20 new entrepeneurs & showcase start- Neil Ward, Senior Sales Director, Daniel Heinz Löfgren, Market Samira Asgari, Postdoctoral Research up companies Miika Ahdesmaki, Principal Scientist, North Europe, Illumina Development Manager, PCR/dPCR -

Fellow, Harvard Medical School

RARE DISEASES MASTERMINDS

Associate Director, AstraZeneca Sponsored by Illumina EMEA/CP, Qiagen ZONE START-UP EQUITABLE ACCESS EQUITABLE Sponsored by Qiagen 16.30 11.30 Powering the precision in “precision

SEQUENCING TECH LANDSCAPE TECH SEQUENCING How Can We Balance the Ethical medicine” - The role of curated data, Network Analysis and Human Single What are the implications of solving the Rapid - Imperative for Scientific Progress databases and knowledge: Does a gold Cell Brain Transcriptomics Reveal “protein folding problem” for genomics? Informed Precision Medicine for Rewriting the Genetic Code ID, VALIDATION TARGET & PRIORITISATION with the Ethical Imperative for standard exist? CLINICAL APPLICATION OF BIOLOGY SYNTHETIC Novel Aspects of Critically Ill Children , KCL, Genomics England Participant Autonomy and Informed 16.40 11.40 Neurodegeneration Related Protein Beate Lizenburger, QIAGEN Digital Insights Office Hours: Sessions to support Julius Fredens, Postdoc, MRC Lab of Dame Janet Thornton, European Consent? Alpha-Synuclein (SNCA) Biology Stephen F. Kingsmore, MD, DSc, Simon Forbes, Wellcome Sanger new entrepeneurs & showcase start- Molecular Biology Bioinformatics Institute Dinesh Kumar, Principal Scientist, President and CEO , Rady Children’s Shruti Rao, Georgetown University up companies John Moult, University of Maryland Nicki Tiffin, Associate Professor, Dominic John, QIAGEN Sanofi Hospital John Jumper, DeepMind University of Cape Town Catherine Snow, Genomics England

17.10 5.30 Networking Break + Exhibition Hall

Updates on the All of Us Research Program 17.30 12.30 Joshua Denny, CEO, All of Us

Such A Lot Of Genome To See… Adapted from Moon River (Henry Mancini, lyrics by Johnny Mercer) 18.00 13.00

Ting Wu, Professor, Department of Genetics, Harvard Medical School GLOBAL KEYNOTES Time Time GMT EST The Festival of Genomics & Biodata - Agenda Day 3 NICE’s Role in Evaluating Innovative Genomic Technologies 9.00 4.00 Meindert Boysen, Deputy CEO, NICE

Empowering Citizens’ Health and the Ecosystem with Open Technology 9.30 4.30 Hema Purohit, Director of Government and Public Sector UK/I, Google Cloud, Andrew Miles, Director Healthcare, EMEA, Google Cloud

UK/EUROPE KEYNOTES UK/EUROPE Qatar Genome; Shedding light on Middle East Genomics at Scale 10.00 5.00 Said Ismail, Director of Qatar Genome, Qatar Foundation

Break & Innovation Talks Automation of Single-Cell Dispensing Technologies for Omics workflows The Sci-Print VX2 Fully-Automated Tube Labeling System – A Product Demo 10.30 5.30 Adrian Zambrano, Single Omics Specialist, Cellink Ryan Eskew, Senior Technical Sales Specialist, NBS Scientific

How to get more from your research data: bioinformatic data analysis report Track 2 Track 10.45 5.45 1 Track AWMGS Fios Genomics 1. MANAGING BIODATA 2. SINGLE CELL ANALYSIS 3. CLINICAL GENOMICS 4. GENOMICS IN RESEARCH 5. DOWN THE RABBIT HOLE MASTERMIND SESSIONS START-UP ZONE

Sequencing all Eukaryotic Diversity Rare Cell Omics in Clinical Research Multi-Omics Data Integrations in Mapping Neural Tissue Architecture in Britain and Ireland: The Darwin

Early Discovery using Spatial Genomics Tree of Life Project Stefan Kirsch, Group Leader, 11.00 6.00 Innovative Molecular Technologies Emma Laing, Director of Omer Bayraktar, Group Leader, Marcela Uliano da Silva, Senior and Biomarker discovery, Fraunhofer Computational Biology, GSK Wellcome Sanger Institute Bioinformatician, Wellcome Sanger ITEM Institute

11.30 6.30 Fuelling the Century of Biology with Capturing biological complexity by Data-Driven External Innovation at a Young Scientist: Transcriptomic Single Cell and Spatial Technologies Using Synthetic Biology to Develop high-resolution single-cell genomics Biotech Company Analysis of Symptomatic and Algal Production Platforms for High Asymptomatic Alzheimer’s Patients Omer Bayraktar, Wellcome Sanger Institute Value Compounds 11.40 6.40 Matthieu Pesant, NGS Product Florian Baumgartner, 10x Genomics Lili Peng, Associate Director, Manager - Scientific Support Holger Heyn, Centre for Genomic Scientific Ecosystem Analytics Lead, Varun Ullanat, Undergraduate, RV Alison Smith, Professor, University Specialist, Takara Bio Europe Regulation (CNAG-CRG) External Innovation, Biogen College of Engineering Stefania Giacomello, SciLifeLab of Cambridge Sponsored by Takara Bio GENOMICS SPATIAL SINGLE CELL ANALYSIS SINGLE CELL Sponsored by 10x Genomics 11.50 6.50 RABBITDOWN THE HOLE

INTEGRATING DIVERSE DATA SETS DIVERSEINTEGRATING DATA Panel: The Future of Single Cell Analysis Creating Empowered Patients by Reconstructing Metabolic Liver Foodomics: Connecting Food Quality and Safety to Our Health and Well-Being

INTEGRATING GENOMICSINTEGRATING INTO CLINICAL TRIALS Removing Stigma from Hereditary Zonation Using Spatial through the Application of Genomic Dan Chang, Single Cell Lead, Merck Disease Transcriptomics 12.00 7.00 Technologies Marilisa Neri, Investigator, NIBR Matthieu Pesant, NGS Product Daniel Barvin, Familial ALS Team Sebastian Bergling, Computational Olivia McAuliffe, Principal Scientist, Manager - Scientific Support Lead, I AM ALS Biologist, Novartis Teagasc Food Research Centre Specialist, Takara Bio Europe Cole Parmer 12.30 7.30 Stephen Bustin, Professor of Molecular Medicine, Anglia Ruskin University

Advantages of Primary Sample Aliquoting for COVID-19 Swab Samples on Hamilton Instruments 12.45 7.45 Nick Gresswell, Senior Applications Specialist, Hamilton Sales and Service UK Ltd

Accelerating drug development through improved gene-disease association using large-scale real-world datasets 13.00 8.00 Robert Lumsden, Director Business Development, Genuity Science

Frozen Sample Aliquotting: Because Thawing Isn’t Cool! 13.15 8.15 Cathy Roesch, Director of Science and Quality, Basque Engineering and Science

13.30 8.30 Networking Break + Exhibition Hall

1. MANAGING BIODATA 2. SINGLE CELL ANALYSIS 3. CLINICAL GENOMICS 4. GENOMICS IN RESEARCH 5. DOWN THE RABBIT HOLE MASTERMIND SESSIONS START-UP ZONE

Leveraging Data and Analytics to Accelerate Discovery Illumina Accelerator 13.40 8.40 Creating Real-World Knowledge Construction, Application and RNA Transcriptomics to Accelerate Genome-Wide Engineering of Emmanuelle Supper, Seven Bridges Single Cell Approaches for CNS Ekaterina Nevedomskaya, Bayer Ursula Arndt Graphs Cataloguing of Polygenic Risk Scores Cancer Research Pathogens Using Synthetic Target Credentialing and Discovery Pharmaceuticals Genomics Atana Kamburov, Bayer Pharmaceuticals Etzard Stolte, Global Head, Michael Inouye, Principal Francesca Buffa, Professor of Mindy Zhang, Principal Scientist, Vivek Iyer, Wellcome Sanger Institute Knowledge Management, Pharma Investigator, University of Computational Biology & Cancer Sanjay Vashee, Associate Professor, Adrian Carr, Kymab Sanofi Technical Development, Roche Cambridge Genomics, University of Oxford J. Craig Venter Institute Julie Gil, Gadeta, Raising investment in the COVID era 14.00 9.00 Pete Clapham, Wellcome Sanger - A story of a UK Healthcare Start-up Vlad Kiselev, Wellcome Sanger, Hakim Yadi, CEO, Closed Loop Brice Sarver, Janssen Medicine Bruce Press, Seven Bridges 14.10 9.10 Opportunities for Preventive High-plex spatially resolved multi- Semantic Modelling & Knowledge Modeling 16p11.2 Copy Number Genomics in Cardiovascular Care omic characterization of FFPE tissues Graph of Biological Data: Challenges Variant utilizing human brain Human System Risks in Spaceflight using Digital® Spatial Profiling & Opportunities organoids and scRNA-seq Amit Khera, Associate Director, Innovate UK 14.20 9.20 Erik Antonsen, Assistant Director, Precision Medicine Unit, Joseph Beechem, Chief Scientific

Nandu Gattu, SVP Pharma Analytics, Milos Kostic, Postdoctoral Fellow, Human System Risk Management, Ian McKay, Innovation Lead, MASTERMINDS Massachusetts General Hospital, Officer and Sr. Vice President of R&D, ZONE START-UP Excelra Novartis Institute for BioMedical NASA Advanced Therapies, Innovate UK

SINGLE CELL ANALYSIS SINGLE CELL and Associate Member, Broad Nanostring Technologies POLYGENIC RISK SCORES Sponsored by Excelra Research RABBITDOWN THE HOLE

14.30 9.30 MANAGEMENT KNOWLEDGE Institute of MIT and Harvard Sponsored by Nanostring How to Remove Bottlenecks of SC Analysis RNA RNA SEQ & TRANSCRIPTOMICS Malte Lücken, Postdoc, Institute of Computational Biology, Helmholtz Zentrum Munchen, Project MinE: an international whole- Using Genomics to Achieve Carlos Talavera-Lopez, Computational genome sequencing initiative and effort Young Scientist: MicroRNA-Modified RNA in Rare Disease Genomic Precision Health for Spaceflight Biologist, Wellcome Sanger A Start Up Story 14.40 9.40 in establishing a Bioinformatics & ML- Milk Investigation For Personalized Diagnostics and its Application for Katerina Boufea, Bioinformatician, Fios Jason Yip, CEO, Tailor Bio Driven approach to study the genetic basis Medicine New Discoveries in COVID19 Jennifer Fogarty, Director of Applied Genomics ALS/MND Health and Extreme Environments, Julian Riba, CSO, CELLINK Berkcan Dogan, PhD Student, Bursa Diana Baralle, Professor, University Sophic Synergistics LLC (formerly Vladimir Kiselev, Head of Cellular Informatics Alfredo Iacoangeli, Research Fellow in Team, Wellcome Sanger Uludag University of Southampton Supporting tomorrow’s genomics and Bioinformatics, King's College London NASA) Catelina Vallejos, Research Group Lead, 15.00 10.00 biodata founders University of Edinburgh Jo Mills

15.10 10.10 Networking Break + Exhibition Hall

1. MANAGING BIODATA 2. SINGLE CELL ANALYSIS 3. CLINICAL GENOMICS 4. GENOMICS IN RESEARCH 5. DOWN THE RABBIT HOLE MASTERMIND SESSIONS START-UP ZONE

An Occupational Health Perspective Comprehensive Genomic From Genomics to Therapeutics: on Genetic Information in Human 15.40 10.40 Surveillance of SARS-CoV-2 Single-Cell Dissection of Human Spaceflight Disease Circuitry Jeffrey Barrett, Director of SARS-CoV- Rebekah Reed, Assistant Director, 2 Genomics Initiative, Sanger Manolis Kellis, Professor of Human Health and Performance Beyond companion diagnostics - what next 16.00 11.00 Institute Computational Biology, MIT Directorate, NASA for ctDNA liquid biopsy in the NHS? Shark Tank: Sessions to support new

Mark Kroese, Director, PHG Foundation entrepeneurs & showcase start-up Science Driven By Space Biology Rachel Butler, Director, South West companies

Genetic Association Analysis of SARS- Exploring the Dark Genome: Genomic Laboratory Hub MASTERMINDS Omics Data Utilizing NASA’s ZONE START-UP COVID ANALYTICS CoV-2 Infection Implications for Precision Medicine Anca Oniscu, Clinical Lead Molecular 16.10 11.10 GeneLab Platform

DOWN THE RABBITDOWN THE HOLE Pathology, Royal Infirmary of Edinburgh Nitzan Rosenfeld, Senior Group Leader,

Jack Kosmiki, Senior Statistical EXPLORING DARK GENOMETHE Tudor Oprea, Professor & Chief, Afshin Beheshti, Bioinformatician Geneticist, Regeneron University of New Mexico School of Cancer Research UK Cambridge Institute, and Principal Investigator, Pharmaceuticals Medicine Laura Blackburn, Head of Science, PHG 16.20 11.20 KBR/NASA Foundation

16.40 11.40 Introduction Genomics in Healthcare: UK Life Sciences 16.50 11.50 Sir John Bell, Regius Professor of Medicine, Medical Sciences Division, University of Oxford

Genomics to Help Us Understand and Control the COVID19 Pandemic 17.30 12.30

Catalina Lopez-Correa, Executive Director of the CanCOGeN, Genome Canada GLOBAL KEYNOTES The Pandemic, Genomics and Digital Technologies 18.00 13.00 Eric Topol, Director & Founder, Scripps Research Translational Institute Time Time GMT EST The Festival of Genomics & Biodata - Agenda Day 4

9.00 4.00 Baroness Nicola Blackwood, Chair, Genomics England

Developing a Treatment for Black Bone Disease 9.30 4.30 Nick Sireau, Chair and CEO, AKU Society

Strengthening Patient Involvement in Research

10.00 5.00 KEYNOTES UK/EUROPE Dan Lewi, Co-Founder and Chief Executive, The CATS Foundation, Paul Wicks, Independent Consultant, Nick Sireau, Chair and CEO, AKU Society

10.30 5.30 Networking Break + Exhibition Hall 1. COVID-19 2. AI AND THE GENOME 3. GENETIC COUNSELLING 4. GENOMICS IN THE NHS 5. PATIENT DATA Educating the NHS Workforce Precision Oncology Through Data Genetic Counsellors – Supporting Data Driven Medicine and the Self- Orchestration, Artificial Intelligence Colleagues and Genomic Education Ed Miller, Senior Education and Learning Healthcare System and Clinical/Preclinical Therapeutics Development Officer, Genomics 11.00 6.00 Amanda Pichini, Bristol Genetics Education Programme Philip Beer, Genome Scientist, Anguraj Sadanandam, Associate Service Sanger Institute and NHS Professor, Institute of Cancer Kate Barr, Bristol Genetics Service Sponsored by Health Education Research England Nursing and its Role in Embedding High-throughput COVID-19 Artificial Intelligence as Part of a Genomics Sequencing: a National Network Clinical Network of Excellence Patient Data - Diversity and Ethical Response Practices Charlotte Hitchcock,Lead Nurse 11.30 6.30 Marco Mazzanti, Scientific Director NHS Genomics (Cancer), Nursing and Cordelia Langford, Director of of International Research Mavis Machirori, Research Fellow, Midwifery Transformation

Scientific Operations, Wellcome Frameworks on Artificial Intelligence DATA PATIENT University of Glasgow Programme NHS England and NHS

Sanger Institute GENOMEAI THE AND in Cardiology, Barts Heart Centre GENETIC COUNSELLING GENETIC COVID 19 & GENOMICS Improvementd

Genetic Counsellors Working with Supporting the Pharmacy Workforce Patient Groups to Deliver Personalised Medicine 12.00 7.00 Jessica Bowen, Sheffield Genetics Sonali Sanghvi, Pharmacy Advisor to Service the Genomics Unit, NHS England Jared Griffin, Annabelle's Challenge

12.30 7.30 Networking Break + Exhibition Hall

1. COVID-19 2. AI AND THE GENOME 3. GENETIC COUNSELLING 4. GENOMICS IN THE NHS 5. PATIENT DATA

Panel: Patients, Genomes and Data The COVID-19 Host Genetics GeNotes: An Online “Just in Time” Application of Geospatial Analytics The Tasks and Opportunities of Storage Initiative Resource for Healthcare to Healthcare Data Applying NLP Across R&D Practitioners 13.40 8.40 Paul Westwood, Consultant Clinical Andrea Ganna, FIMM-EMBL Group Ashlee Hamel, System Manager, Peter Henstock, Machine Learning & Scientist, West of Scotland Centre Leader, Institute for Molecular Kate Tatton-Brown, Professor, St Pharmacy Clinical Programs, Sentara AI Technical Lead, Pfizer for Genomic Medicine Medicine Finland George’s University Hospital Healthcare Catherine Watt, Genetic Counsellor, AGNC QIAprep& Viral RNA UM Kit for Panel: Tools to Educate the NHS Nick Meade, Genetic Alliance UK debottlenecking SARS-CoV-2 Charlotta Involgstad Malmgren, research Charlotte Hitchcock, NHS England Genetic Counsellor, Karolinska Sonali Sanghvi, NHS England 14.10 9.10 University Hospital Ed Miller, Genomics Education Ina Scheuerpflug, Director, Strategic NHS Nicki Taverner, Chair, AGNC Programme Marketing for PCR and Digital PCR Stacey McPherson, Patient Kate Tatton-Brown, St George's University

Solutions, QIAGEN Hospital AI AND THE GENOMEAI THE AND Sponsored by QIAGEN COUNSELLING GENETIC Fraser Woodward, NHS England

The GenOMICC study - Uncovering Genetic Counselling in a Global Cancer Genomics Education in a Data Science & the Digital Divide: Host Genetic Mechanisms of Pandemic Clinical Care Pathway Public Health challenges in LMICs Disease in COVID-19 14.40 9.40 Jonathan Roberts, Registered Vishakha Tripathi, Consultant Amel Ghouila, Scientific Coordinator, Kenneth Baillie, Lab Head, University Genetic Counsellor, Addenbrooke's Genetic Counsellor, Guy’s and St Exaptive for the Bill and Melinda of Edinburgh and PI, GenOMICC Hospital Thomas’ NHS Foundation Trust Gates Foundation

15.10 10.10 Closing Remarks