MMP24 Antibody Cat. No.: 62-177

MMP24 Antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY: Human

HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse, Rat

This MMP24 antibody is generated from rabbits immunized with a KLH conjugated IMMUNOGEN: synthetic peptide between 396-425 amino acids from the Central region of human MMP24.

TESTED APPLICATIONS: IHC-P, WB

For WB starting dilution is: 1:1000 APPLICATIONS: For IHC-P starting dilution is: 1:50~100

September 28, 2021 1 https://www.prosci-inc.com/mmp24-antibody-62-177.html PREDICTED MOLECULAR 73 kDa WEIGHT:

Properties

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by PURIFICATION: dialysis

CLONALITY: Polyclonal

ISOTYPE: Rabbit Ig

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.

CONCENTRATION: batch dependent

Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies STORAGE CONDITIONS: care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

OFFICIAL SYMBOL: MMP24

Matrix -24, MMP-24, 3424-, Membrane-type 5, ALTERNATE NAMES: MT-MMP 5, MTMMP5, Membrane-type-5 matrix metalloproteinase, MT5-MMP, MT5MMP, Processed matrix metalloproteinase-24, MMP24, MT5MMP

ACCESSION NO.: Q9Y5R2

PROTEIN GI NO.: 12585280

GENE ID: 10893

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when BACKGROUND: cleaved by extracellular proteinases. However, MMP24 is a member of the membrane- type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).

REFERENCES: 1) Jung, M., et al., Prostate 55(2):89-98 (2003).

September 28, 2021 2 https://www.prosci-inc.com/mmp24-antibody-62-177.html 2) Kajita, M., et al., FEBS Lett. 457(3):353-356 (1999).

3) Llano, E., et al., Cancer Res. 59(11):2570-2576 (1999).

4) Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).

ANTIBODIES FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.

September 28, 2021 3 https://www.prosci-inc.com/mmp24-antibody-62-177.html